{
    "abstract": "Hyaluronic acid (HA) fillers offer a minimally invasive alternative for breast augmentation, appealing to young female patients seeking natural results and minimal recovery time. However, achieving optimal outcomes requires a thorough understanding of breast anatomy, filler properties, and safe injection techniques. This study provides a comprehensive analysis of the anatomical considerations, techniques, and filler properties necessary for optimal breast augmentation using HA filler. It also explores patient selection, long-term safety and efficacy, and the management of complications. A review of key anatomical structures, including glandular tissue, fascial layers, vascular anatomy, and Cooper's ligaments was conducted. Injection techniques, such as dual-plane and submuscular approaches, were analysed with a focus on pre-procedural imaging. Four cases of young female patients undergoing breast augmentation using HA filler (e.p.t.q. eve X, Jetema Inc., Seoul, Republic of Korea) were analysed. The efficacy of HA fillers in achieving natural breast enhancement was demonstrated in all four cases. Ultrasound played a crucial role in ensuring accurate filler placement, reducing risks like vascular occlusion and filler migration. Patients reported high satisfaction and minimal complications, though periodic treatments were required for maintenance. HA filler-based breast augmentation is a safe and effective option for young female patients, delivering natural results with rapid recovery. Although the results can be temporary and maintenance treatment is required, HA fillers may offer a non-invasive alternative to silicone implants. Optimal outcomes can be achieved through a thorough understanding of anatomy, the use of highly cohesive fillers, and ultrasound-guided injection techniques.",
    "authors": [
        {
            "affiliation": "247 Clinic, 108 Bongeunsa-ro, Gangnam District, Seoul, Republic of Korea.",
            "firstname": "Jae Hun",
            "initials": "JH",
            "lastname": "Hur"
        },
        {
            "affiliation": "Medical Research Inc., Wonju, Republic of Korea.",
            "firstname": "Jovian",
            "initials": "J",
            "lastname": "Wan"
        },
        {
            "affiliation": "BRANDNEW Aesthetic Surgery Clinic, Seoul, Republic of Korea.",
            "firstname": "Song Eun",
            "initials": "SE",
            "lastname": "Yoon"
        },
        {
            "affiliation": "Leciel Medical Centre, Hong Kong.",
            "firstname": "Sky",
            "initials": "S",
            "lastname": "Wong"
        },
        {
            "affiliation": "Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.\nYou and I Clinic, Seoul 06001, Republic of Korea.",
            "firstname": "Kyu-Ho",
            "initials": "KH",
            "lastname": "Yi"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/life15040624\n10.3390/ijms241210296\n10.1097/PRS.0b013e318200ae57\n10.3389/fmicb.2023.1297948\n10.3390/app11167493\n10.1016/j.jss.2022.06.073\n10.1053/j.tvir.2013.12.002\n10.1097/PRS.0000000000004948\n10.1097/GRF.0b013e318207ffe9\n10.1097/PRS.0000000000008671\n10.1007/s00268-016-3481-6\n10.1177/1090820X13519643\n10.1016/j.csm.2014.06.005\n10.1016/j.bjps.2022.10.021\n10.1097/PRS.0000000000009306\n10.1016/S0007-1226(96)90218-0\n10.1016/S0007-1226(97)91155-3\n10.1097/SAP.0000000000003832\n10.1080/00140139.2013.777798\n10.1007/s00266-012-9892-3\n10.1007/s13244-010-0021-z\n10.1097/GOX.0000000000005469\n10.3390/ijms231810518\n10.3390/polym16192739\n10.4103/0974-2077.172191\n10.1097/MD.0000000000021516\n10.1007/s00266-018-1107-0\n10.1016/j.jpra.2024.01.009\n10.1111/jocd.12726\n10.3390/diagnostics13233512",
    "journal": "Life (Basel, Switzerland)",
    "keywords": [
        "anatomy",
        "breast augmentation",
        "cross-sectional",
        "hyaluronic acid",
        "injections",
        "interventional",
        "subcutaneous",
        "ultrasonography"
    ],
    "methods": null,
    "publication_date": "2025-04-26",
    "pubmed_id": "40283178\n37564462\n37313510\n24675209\n32766047\n27219264\n25332644\n37373443\n19967357\n36177802\n24507861\n20966812\n38260874\n35969932\n24636325\n30511967\n21278507\n34936599\n35482144\n26943658\n24402060\n25280620\n36521264\n35652898\n8785595\n9215081\n38685499\n23514244\n22535137\n22347910\n38111726\n36142430\n35293660\n39408450\n23044151\n17099485\n38763057\n28280660\n34188752\n36594153\n37564711\n26865784\n32871998\n37721627\n29487999\n38389650\n20362523\n24556529\n30084182\n31624663\n33447570\n27960235\n25482689\n38066753\n26887446\n31275800\n23142937",
    "results": null,
    "title": "Anatomical Considerations for Hyaluronic Acid Filler Injection for Breast Augmentation in Young Female Patients.",
    "xml": "<Element 'PubmedArticle' at 0x7885037545e0>"
}