{
    "abstract": "The severe acute respiratory syndrome Coronarovirus-2 associated still causes a significant number of deaths and hospitalizations mainly by the development of respiratory failure. We aim to validate lung ultrasound score in order to predict mortality and the severity of the clinical course related to the need of respiratory support.\nIn this prospective multicenter hospital-based cohort study, all adult patients with diagnosis of SARS-CoV-2 infection, performed by real-time reverse transcription polymerase chain reaction were included. Upon admission, all patients underwent blood gas analysis and lung ultrasound by expert operators. The acquisition of ultrasound scan was performed on 12 peculiar anatomic landmarks of the chest. Lung ultrasound findings were classified according to a scoring method, ranging 0 to 3: \nOne thousand and seven patients were included in statistical analysis (male 62.4 %, mean age 66.3). Oxygen support was needed in 811 (80.5 %) patients. The median ultrasound score was 24 and the risk of having more invasive respiratory support increased in relation to higher values score computed. Lung ultrasound score showed negative strong correlation (rho: -0.71) with the P/F ratio and a significant association with in-hospital mortality (OR 1.11, 95 %CI 1.07-1.14; \nThe novelty of this research corroborates and validates the 12-field lung ultrasound score as tool for predicting mortality and severity clinical course in COVID-19 patients. Baseline lung ultrasound score was associated with in-hospital mortality and requirement of intensive respiratory support and predict the risk of IOT among COVID-19 patients.",
    "authors": [
        {
            "affiliation": "Department of Medicine and Health Sciences \"V. Tiberio\", Universit\u00e0 degli Studi del Molise, Campobasso, Italy.\nDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "L",
            "initials": "L",
            "lastname": "Rinaldi"
        },
        {
            "affiliation": "Internal Medicine Unit, ASL Center Naples 1, P.O. Ospedale del Mare, Naples, Italy.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Lugar\u00e0"
        },
        {
            "affiliation": "Department of Mental and Physical Health and Preventive Medicine, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "V",
            "initials": "V",
            "lastname": "Simeon"
        },
        {
            "affiliation": "Department of Translational Medical Sciences, University of Campania L. Vanvitelli, \"Monaldi\" Hospital, Naples, Italy.",
            "firstname": "F",
            "initials": "F",
            "lastname": "Perrotta"
        },
        {
            "affiliation": "Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Romano"
        },
        {
            "affiliation": "Department of Pneumology and Oncology, Monaldi Hospital, Azienda dei Colli, Naples, Italy.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Iadevaia"
        },
        {
            "affiliation": "Department of Mental and Physical Health and Preventive Medicine, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Sagnelli"
        },
        {
            "affiliation": "Emergency Department, M.G. Vannini Hospital, \"Istituto delle Figlie di San Camillo\", Rome, Italy.",
            "firstname": "L",
            "initials": "L",
            "lastname": "Monaco"
        },
        {
            "affiliation": "Emergency Medicine Unit, S. M. delle Grazie Hospital, Pozzuoli, Italy.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Altruda"
        },
        {
            "affiliation": "Emergency Medicine Unit, Bassini Hospital, ASST North Milan, Italy.",
            "firstname": "M C",
            "initials": "MC",
            "lastname": "Fascione"
        },
        {
            "affiliation": "Department of Emergency Medicine, San Giovanni di Dio Hospital, Melfi, AOR Azienda Ospedaliera Regionale San Carlo, Potenza, Italy.",
            "firstname": "L",
            "initials": "L",
            "lastname": "Restivo"
        },
        {
            "affiliation": "IX Division of Interventional Ultrasound Cotugno Hospital, Azienda dei Colli, Naples, Italy.",
            "firstname": "U",
            "initials": "U",
            "lastname": "Scognamiglio"
        },
        {
            "affiliation": "Department of Clinical and Experimental Medicine, University of Messina, Italy.",
            "firstname": "N",
            "initials": "N",
            "lastname": "Lagan\u00e0"
        },
        {
            "affiliation": "Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "R",
            "initials": "R",
            "lastname": "Nevola"
        },
        {
            "affiliation": "Internal Medicine Unit, ASL Center Naples 1, P.O. Ospedale del Mare, Naples, Italy.",
            "firstname": "G",
            "initials": "G",
            "lastname": "Oliva"
        },
        {
            "affiliation": "Internal Medicine Unit, ASL Center Naples 1, P.O. Ospedale del Mare, Naples, Italy.",
            "firstname": "M G",
            "initials": "MG",
            "lastname": "Coppola"
        },
        {
            "affiliation": "Department of Emergency Medicine, Azienda Ospedaliera Regionale San Carlo, Potenza, Italy.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Acierno"
        },
        {
            "affiliation": "Foundation \"Policlinico Universitario Campus-Biomedico\", Rome, Italy.",
            "firstname": "F",
            "initials": "F",
            "lastname": "Masini"
        },
        {
            "affiliation": "Internal Medicine Unit, San Giovanni Addolorata Hospital, Rome, Italy.",
            "firstname": "E",
            "initials": "E",
            "lastname": "Pinotti"
        },
        {
            "affiliation": "Emergency Medicine Unit, S. M. delle Grazie Hospital, Pozzuoli, Italy.",
            "firstname": "E",
            "initials": "E",
            "lastname": "Allegorico"
        },
        {
            "affiliation": "Department of Radiology, ASL Center Naples 1, P.O. Ospedale del Mare, Naples, Italy.",
            "firstname": "S",
            "initials": "S",
            "lastname": "Tamburrini"
        },
        {
            "affiliation": "Internal Medicine Unit, ASL Center Naples 1, P.O. Ospedale del Mare, Naples, Italy.",
            "firstname": "G",
            "initials": "G",
            "lastname": "Vitiello"
        },
        {
            "affiliation": "Department of Precision Medicine, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Niosi"
        },
        {
            "affiliation": "IRCSS Ospedale Pediatrico Bambin Ges\u00f9, Rome, Italy; 5Emergency Department, M.G. Vannini Hospital, \"Istituto delle Figlie di San Camillo\", Rome, Italy.",
            "firstname": "M L",
            "initials": "ML",
            "lastname": "Burzo"
        },
        {
            "affiliation": "Department of Medicine, Surgery and Dentistry, \"Scuola Medica Salernitana\", University of Salerno, Baronissi, Italy.",
            "firstname": "G",
            "initials": "G",
            "lastname": "Franci"
        },
        {
            "affiliation": "Department of Highly Contagious Emerging Diseases, Azienda dei Colli, Cotugno Hospital, Naples, Italy.",
            "firstname": "A",
            "initials": "A",
            "lastname": "Perrella"
        },
        {
            "affiliation": "Department of Mental and Physical Health and Preventive Medicine, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "G",
            "initials": "G",
            "lastname": "Signoriello"
        },
        {
            "affiliation": "Department of Emergency Medicine, San Giovanni di Dio Hospital, Melfi, AOR Azienda Ospedaliera Regionale San Carlo, Potenza, Italy.",
            "firstname": "V",
            "initials": "V",
            "lastname": "Frusci"
        },
        {
            "affiliation": "Emergency Medicine Unit, Bassini Hospital, ASST North Milan, Italy.",
            "firstname": "S",
            "initials": "S",
            "lastname": "Mancarella"
        },
        {
            "affiliation": "Emergency Medicine Unit, Bassini Hospital, ASST North Milan, Italy.",
            "firstname": "G",
            "initials": "G",
            "lastname": "Loche"
        },
        {
            "affiliation": "Unit of Infectious Disease, Department of Adult and Childhood Human pathology, \"Gaetano Barresi\", University of Messina, Italy.",
            "firstname": "G F",
            "initials": "GF",
            "lastname": "Pellicano"
        },
        {
            "affiliation": "Unit of Infectious Disease, Department of Adult and Childhood Human pathology, \"Gaetano Barresi\", University of Messina, Italy.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Berretta"
        },
        {
            "affiliation": "IX Division of Interventional Ultrasound Cotugno Hospital, Azienda dei Colli, Naples, Italy.",
            "firstname": "G",
            "initials": "G",
            "lastname": "Calabria"
        },
        {
            "affiliation": "Emergency Department, M.G. Vannini Hospital, \"Istituto delle Figlie di San Camillo\", Rome, Italy.",
            "firstname": "L",
            "initials": "L",
            "lastname": "Pietropaolo"
        },
        {
            "affiliation": "Emergency Medicine Unit, S. M. delle Grazie Hospital, Pozzuoli, Italy.",
            "firstname": "F G",
            "initials": "FG",
            "lastname": "Numis"
        },
        {
            "affiliation": "Department of Mental and Physical Health and Preventive Medicine, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "N",
            "initials": "N",
            "lastname": "Coppola"
        },
        {
            "affiliation": "Department of Critical Area, Monaldi Hospital, Azienda dei Colli, Naples, Italy.",
            "firstname": "A",
            "initials": "A",
            "lastname": "Corcione"
        },
        {
            "affiliation": "Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "R",
            "initials": "R",
            "lastname": "Marfella"
        },
        {
            "affiliation": "Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "L E",
            "initials": "LE",
            "lastname": "Adinolfi"
        },
        {
            "affiliation": "Department of Translational Medical Sciences, University of Campania L. Vanvitelli, \"Monaldi\" Hospital, Naples, Italy.",
            "firstname": "A",
            "initials": "A",
            "lastname": "Bianco"
        },
        {
            "affiliation": "Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "F C",
            "initials": "FC",
            "lastname": "Sasso"
        },
        {
            "affiliation": "Department of Precision Medicine, University of Campania L. Vanvitelli, Naples, Italy.",
            "firstname": "I",
            "initials": "I",
            "lastname": "de Sio"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1016/j.pulmoe.2024.04.012",
    "journal": "Pulmonology",
    "keywords": [
        "Lung ultrasound",
        "Non-invasive ventilation",
        "Respiratory failure",
        "Sars-CoV-2 viral infection"
    ],
    "methods": null,
    "publication_date": "2024-05-29",
    "pubmed_id": "38806368",
    "results": "One thousand and seven patients were included in statistical analysis (male 62.4 %, mean age 66.3). Oxygen support was needed in 811 (80.5 %) patients. The median ultrasound score was 24 and the risk of having more invasive respiratory support increased in relation to higher values score computed. Lung ultrasound score showed negative strong correlation (rho: -0.71) with the P/F ratio and a significant association with in-hospital mortality (OR 1.11, 95 %CI 1.07-1.14; ",
    "title": "Application and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study.",
    "xml": "<Element 'PubmedArticle' at 0x788503cb9120>"
}