{
    "abstract": "Agrochemicals play an important role in solving global food problems and achieving a safe and sustainable society by protecting crops from pests and diseases, controlling weeds, and protecting human and animal health. The evolution of insecticide-resistant pests is a serious problem worldwide, and repeated use of insecticides with the same mode of action (MoA) promotes the evolution of resistance. Therefore, the development of insecticides with novel MoAs is important for controlling pests that are resistant to existing insecticides, thereby preventing the depletion of effective insecticides. In this study, based on genetic studies in Caenorhabditis elegans and biochemical studies in Drosophila melanogaster, we found that a new insecticide under development, cybenzoxasulfyl, binds directly to the vesicular acetylcholine transporter (VAChT) with low nanomolar K",
    "authors": [
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan. Electronic address: yasunaga-ryoko@nichino.co.jp.",
            "firstname": "Ryoko",
            "initials": "R",
            "lastname": "Yasunaga"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Motofumi",
            "initials": "M",
            "lastname": "Nakano"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Tatsuhiko",
            "initials": "T",
            "lastname": "Kyuma"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Karin",
            "initials": "K",
            "lastname": "Fujii"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Hiroshi",
            "initials": "H",
            "lastname": "Inui"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Junichi",
            "initials": "J",
            "lastname": "Akutsu"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Ikki",
            "initials": "I",
            "lastname": "Yonemura"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Takafumi",
            "initials": "T",
            "lastname": "Inoue"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Akiyuki",
            "initials": "A",
            "lastname": "Suwa"
        },
        {
            "affiliation": "Nihon Nohyaku Co., Ltd., Research Center, 345, Oyamada-cho, Kawachinagano-shi, Osaka, 586-0094, Japan.",
            "firstname": "Takashi",
            "initials": "T",
            "lastname": "Yoshizane"
        },
        {
            "affiliation": "Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto, 615-8510, Japan; Department of Pharmacology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.",
            "firstname": "Akito",
            "initials": "A",
            "lastname": "Nakao"
        },
        {
            "affiliation": "Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto, 615-8510, Japan.",
            "firstname": "Yasuo",
            "initials": "Y",
            "lastname": "Mori"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.bbrc.2025.151792",
    "journal": "Biochemical and biophysical research communications",
    "keywords": [
        "Cholinergic signaling",
        "Cybenzoxasulfyl",
        "Metabolism",
        "Mode of action (MoA)",
        "Neurotoxicology",
        "Vesamicol",
        "Vesicular acetylcholine transporter (VAChT)"
    ],
    "methods": null,
    "publication_date": "2025-04-15",
    "pubmed_id": "40233436",
    "results": null,
    "title": "A novel insecticide cybenzoxasulfyl potently binds to vesicular acetylcholine transporter and disrupts the storage and release of acetylcholine in insects.",
    "xml": "<Element 'PubmedArticle' at 0x7885026bb9c0>"
}