{
    "abstract": "To describe the regional distribution patterns of tidal ventilation within the lung during mechanical ventilation that is synchronous or asynchronous with an infant's own breathing effort.\nIntubated infants receiving synchronized mechanical ventilation at The Royal Children's Hospital neonatal intensive care unit were studied. During four 10-minute periods of routine care, regional distribution of tidal volume (V\nIn total, 2749 inflations (2462 synchronous) were analyzed in 19 infants; mean (SD) age 28 (30) days, gestational age 35 (5) weeks. Synchronous inflations were associated with a shorter respiratory cycle (P\u00a0=\u00a0.004) and more homogenous V\nSynchronous mechanical ventilator lung inflations generate more gravity-dependent lung ventilation and more uniform right-to-left ventilation than asynchronous inflations.",
    "authors": [
        {
            "affiliation": "Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia.",
            "firstname": "Georgie",
            "initials": "G",
            "lastname": "Dowse"
        },
        {
            "affiliation": "Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia; Department of Neonatology, The Royal Children's Hospital, Parkville, Australia.",
            "firstname": "Elizabeth",
            "initials": "E",
            "lastname": "Perkins"
        },
        {
            "affiliation": "Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia.",
            "firstname": "Jessica",
            "initials": "J",
            "lastname": "Thomson"
        },
        {
            "affiliation": "Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia.",
            "firstname": "Nicholas",
            "initials": "N",
            "lastname": "Schinckel"
        },
        {
            "affiliation": "Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia.",
            "firstname": "Prue",
            "initials": "P",
            "lastname": "Pereira-Fantini"
        },
        {
            "affiliation": "Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia; Department of Neonatology, The Royal Children's Hospital, Parkville, Australia. Electronic address: david.tingay@rch.org.au.",
            "firstname": "David",
            "initials": "D",
            "lastname": "Tingay"
        }
    ],
    "conclusions": null,
    "copyrights": "Crown Copyright \u00a9 2020. Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.jpeds.2020.08.043",
    "journal": "The Journal of pediatrics",
    "keywords": [
        "infant",
        "mechanical ventilation",
        "regional ventilation",
        "synchronization"
    ],
    "methods": null,
    "publication_date": "2020-08-23",
    "pubmed_id": "32827530",
    "results": "In total, 2749 inflations (2462 synchronous) were analyzed in 19 infants; mean (SD) age 28 (30) days, gestational age 35 (5) weeks. Synchronous inflations were associated with a shorter respiratory cycle (P\u00a0=\u00a0.004) and more homogenous V",
    "title": "Synchronized Inflations Generate Greater Gravity-Dependent Lung Ventilation in Neonates.",
    "xml": "<Element 'PubmedArticle' at 0x788502e7c360>"
}