{
    "abstract": "To describe a peculiar combination of cytogenetic abnormalities in a tripronuclear zygote obtained after intracytoplasmic sperm injection (ICSI).\nCase report.\nA university hospital.\nA couple with a 4-year history of primary infertility. Intracytoplasmic sperm injection was performed because of male factor infertility (oligoteratozoospermia).\nUltrasound-guided transvaginal follicular aspiration.\nChromosomal karyotype of a tripronuclear one-cell zygote.\nUnexpectedly, a tetraploid [92,XXYY, end3, -18, end18] chromosome complement was found, indicating injection of a diploid spermatozoon carrying two Y chromosomes. The parental origin of the other abnormalities could not be determined. The missing chromosomes may be attributed either to a hypodiploid [44,YY,-18,-18] sperm cell or to a hypohaploid [22,X,-18] oocyte. The exact tetraploid count was restored by endoreduplication of two chromosomes. This event could have occurred in one and the same or in two different pronuclei.\nCytogenetic analysis of multipronuclear zygotes appears useful for assessing the incidence of chromosomal abnormalities at the earliest stage of conception. In addition to other methods, it also may contribute to evaluation of the transmission of aberrations by spermatozoa from infertile men.",
    "authors": [
        {
            "affiliation": "Department of Gynecology and Obstetrics, University of Ulm, Germany.",
            "firstname": "B E",
            "initials": "BE",
            "lastname": "Rosenbusch"
        },
        {
            "affiliation": null,
            "firstname": "M",
            "initials": "M",
            "lastname": "Schneider"
        },
        {
            "affiliation": null,
            "firstname": "V",
            "initials": "V",
            "lastname": "Hanf"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1016/s0015-0282(97)00470-6",
    "journal": "Fertility and sterility",
    "keywords": [],
    "methods": null,
    "publication_date": "1998-03-13",
    "pubmed_id": "9496353",
    "results": null,
    "title": "Tetraploidy and partial endoreduplication in a tripronuclear zygote obtained after intracytoplasmic sperm injection.",
    "xml": "<Element 'PubmedArticle' at 0x788504997560>"
}