{
    "abstract": "SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in response to reactive oxygen species, we hypothesized that SERCA oxidation at C674 would modulate the effects of reactive oxygen species on mitochondrial calcium and mitochondria-dependent apoptosis in cardiac myocytes.\nAdult rat ventricular myocytes expressing wild-type SERCA2b or a redox-insensitive mutant in which C674 is replaced by serine (C674S) were exposed to H\nIn adult rat ventricular myocytes expressing wild-type SERCA, H\nRedox activation of SERCA C674 regulates basal SR calcium content, thereby mediating the pathologic reactive oxygen species-stimulated rise in mitochondrial calcium required for myocyte apoptosis and myocardial failure.",
    "authors": [
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Jena B",
            "initials": "JB",
            "lastname": "Goodman"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Fuzhong",
            "initials": "F",
            "lastname": "Qin"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Robert J",
            "initials": "RJ",
            "lastname": "Morgan"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Jordan M",
            "initials": "JM",
            "lastname": "Chambers"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Dominique",
            "initials": "D",
            "lastname": "Croteau"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Deborah A",
            "initials": "DA",
            "lastname": "Siwik"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Ion",
            "initials": "I",
            "lastname": "Hobai"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Marcello",
            "initials": "M",
            "lastname": "Panagia"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Ivan",
            "initials": "I",
            "lastname": "Luptak"
        },
        {
            "affiliation": "Vascular Biology Unit (M.B., X.T., R.A.C.), Boston University School of Medicine, MA.",
            "firstname": "Markus",
            "initials": "M",
            "lastname": "Bachschmid"
        },
        {
            "affiliation": "Vascular Biology Unit (M.B., X.T., R.A.C.), Boston University School of Medicine, MA.",
            "firstname": "XiaoYong",
            "initials": "X",
            "lastname": "Tong"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "David R",
            "initials": "DR",
            "lastname": "Pimentel"
        },
        {
            "affiliation": "Vascular Biology Unit (M.B., X.T., R.A.C.), Boston University School of Medicine, MA.",
            "firstname": "Richard A",
            "initials": "RA",
            "lastname": "Cohen"
        },
        {
            "affiliation": "Cardiovascular Medicine Section (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.\nMyocardial Biology Unit (J.B.G.., F.Q., R.J.M., J.M.C., D.C., D.A.S., I.H., M.P., I.L., D.R.P., W.S.C.), Boston University School of Medicine, MA.",
            "firstname": "Wilson S",
            "initials": "WS",
            "lastname": "Colucci"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/CIRCULATIONAHA.120.048183",
    "journal": "Circulation",
    "keywords": [
        "apoptosis",
        "calcium",
        "heart failure",
        "mitochondria",
        "myocytes, cardiac",
        "sarcoplasmic reticulum"
    ],
    "methods": null,
    "publication_date": "2020-10-21",
    "pubmed_id": "33076678\n11991728\n17190878\n21311045\n26755553\n19008475\n31756525\n20508180\n24633550\n16210547\n26217001\n22679139\n15489859\n19265039\n20132882\n24920669\n12788379\n31299273\n9147318\n12574140\n23963753\n28410273\n20018955\n12031984\n19406269\n22012956\n28262504\n19515844\n9218515\n21709064",
    "results": "In adult rat ventricular myocytes expressing wild-type SERCA, H",
    "title": "Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.",
    "xml": "<Element 'PubmedArticle' at 0x788503d27100>"
}