{
    "abstract": "Malnutrition, characterized by a total serum lymphocyte count less than 1500 cells/mm\u00b3\u202fand serum albumin levels below 3.5\u202fg/dL, is linked to delayed wound healing and a higher incidence of surgical site infections (SSIs). This meta-analysis evaluates the impact of perioperative nutritional supplementation on clinical outcomes in spine surgery.\nA systematic review of the published literature was conducted. Outcomes of interest included postoperative complications such as wound complications, SSI, and deep vein thrombosis (DVT). Estimated blood loss, operative time, and duration of hospital stay were also investigated.\nFive studies with 554 patients were included. A total of 221 patients (39.90\u202f%) were in the intervention group, compared to 333 patients (60.10\u202f%) in the control group. The intervention groups received nutritional supplementation at different timeframes, including preoperatively or postoperatively. A significantly lower rate of total complications (OR: 0.32, CI: [0.12, 0.89], p\u202f=\u202f0.04) and wound-related complications (OR: 0.34, CI: [0.20, 0.60], p\u202f<\u202f0.01) was observed in the intervention group when compared to the control group. A trend towards fewer SSIs was observed (OR: 0.35, CI: [0.02, 7.19], p\u202f=\u202f0.39). There were also fewer DVT events in the intervention group (OR: 0.62, CI: [0.04, 8.90], p\u202f=\u202f0.52).\nPatients receiving perioperative nutritional supplementation had significantly lower overall and wound-related complication rates compared to patients who did not receive nutritional supplementation perioperatively. This analysis highlights the value of nutritional supplementation as part of the perioperative care and optimization efforts in patients undergoing spine surgery.",
    "authors": [
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates.",
            "firstname": "Ahmad",
            "initials": "A",
            "lastname": "Sharif"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Psychological and Brain Sciences, Villanova University, Villanova, PA, USA.",
            "firstname": "Alison",
            "initials": "A",
            "lastname": "Reilly"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Vanderbilt University, Nashville, TN, USA.",
            "firstname": "Ojas",
            "initials": "O",
            "lastname": "Bhagra"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; University of Minnesota Medical School, Minneapolis, MN, USA.",
            "firstname": "Karthik",
            "initials": "K",
            "lastname": "Papisetty"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.",
            "firstname": "Hamzah",
            "initials": "H",
            "lastname": "Magableh"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.",
            "firstname": "Asimina",
            "initials": "A",
            "lastname": "Dominari"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.",
            "firstname": "Karim Rizwan",
            "initials": "KR",
            "lastname": "Nathani"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.",
            "firstname": "Maliya",
            "initials": "M",
            "lastname": "Delawan"
        },
        {
            "affiliation": "Mayo Clinic Neuro-Informatic Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: bydon.mohamad@mayo.edu.",
            "firstname": "Mohamad",
            "initials": "M",
            "lastname": "Bydon"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.clineuro.2025.108916",
    "journal": "Clinical neurology and neurosurgery",
    "keywords": [
        "Nutritional supplementation",
        "Perioperative",
        "Wound complications"
    ],
    "methods": null,
    "publication_date": "2025-04-28",
    "pubmed_id": "40288287",
    "results": "Five studies with 554 patients were included. A total of 221 patients (39.90\u202f%) were in the intervention group, compared to 333 patients (60.10\u202f%) in the control group. The intervention groups received nutritional supplementation at different timeframes, including preoperatively or postoperatively. A significantly lower rate of total complications (OR: 0.32, CI: [0.12, 0.89], p\u202f=\u202f0.04) and wound-related complications (OR: 0.34, CI: [0.20, 0.60], p\u202f<\u202f0.01) was observed in the intervention group when compared to the control group. A trend towards fewer SSIs was observed (OR: 0.35, CI: [0.02, 7.19], p\u202f=\u202f0.39). There were also fewer DVT events in the intervention group (OR: 0.62, CI: [0.04, 8.90], p\u202f=\u202f0.52).",
    "title": "Impact of perioperative nutritional supplementation on outcomes of spine surgery: A systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788504bff740>"
}