{
    "abstract": "BackgroundWhile the underlying mechanisms of agitation are not fully understood in people with Alzheimer's disease and related disorders, research suggests that dysregulated neuroendocrine processes, including the hypothalamic-pituitary-adrenal axis, may play a role.ObjectiveThis study aimed to explore the associations between salivary cortisol, melatonin at baseline, and agitation both at baseline and at post-intervention.MethodsThis study was a secondary analysis of a two-group, randomized, parallel designed clinical trial of 210 people living with cognitive impairment. Agitation, salivary cortisol, and salivary melatonin were measured at baseline and four weeks. Salivary cortisol and melatonin indicators were generated through three timepoints of cortisol and melatonin collection across the two consecutive days. Presence of agitation was measured using the Neuropsychiatric Inventory. Logistic regressions were conducted to achieve the aim.ResultsA significant association was found at baseline between diurnal cortisol slope and agitation (OR\u2009=\u20090.03, ",
    "authors": [
        {
            "affiliation": "School of Medicine, Washington University, St. Louis, MO, USA.",
            "firstname": "Fanghong",
            "initials": "F",
            "lastname": "Dong"
        },
        {
            "affiliation": "College of Nursing, University of Iowa, Iowa City, IA, USA.",
            "firstname": "Alison R",
            "initials": "AR",
            "lastname": "Anderson"
        },
        {
            "affiliation": "School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.",
            "firstname": "Nancy A",
            "initials": "NA",
            "lastname": "Hodgson"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1177/13872877251322206",
    "journal": "Journal of Alzheimer's disease : JAD",
    "keywords": [
        "Alzheimer's disease",
        "agitation",
        "cognitive impairment",
        "diurnal cortisol",
        "melatonin"
    ],
    "methods": null,
    "publication_date": "2025-03-21",
    "pubmed_id": "40116653",
    "results": null,
    "title": "Associations among diurnal cortisol, melatonin, and agitation in people living with cognitive impairment.",
    "xml": "<Element 'PubmedArticle' at 0x78850532b6f0>"
}