{
    "abstract": "Flow diverters (FDs) are being increasingly used off-label for treatment of intracranial vertebral artery dissection aneurysms (IVADAs). However, the safety and efficacy of FDs for unruptured IVADAs remain unclear. This study was performed to investigate whether FDs-alone are safer and more effective than conventional stent-asisted coiling.\nWe retrospectively analyzed 152 patients who underwent endovascular stenting from December 2011 to December 2022. The baseline data, aneurysm characteristics, surgical details, perioperative complications, follow-up angiography, and clinical outcomes were collected and compared between patients who underwent stenting with FD-alone versus conventional stent-asisted coiling. Propensity score matching was also conducted.\nAll 152 patients underwent successful endovascular therapy. Forty patients were treated with FDs-alone, and 112 were treated with conventional stent-asisted coiling (including 62 with double stents). The complete occlusion rate was 93.75% in the FD group and 93.61% in the conventional stent group (p\u2009=\u20090.979). The complication rate was 5.00% in the FD group and 8.93% in the conventional stent group (p\u2009=\u20090.653). The in-stent restenosis rate was 3.13% in the FD group and 5.32% in the conventional stent group (p\u2009=\u20090.615). The procedure duration was significantly shorter in the FD than conventional stent group (p\u2009=\u20090.034). After propensity score matching, 37 patients with FDs were successfully matched, and the procedure duration was still significantly shorter in the FD group (p\u2009=\u20090.042).\nFD placement is a safe and effective treatment for IVADAs. It is also a simpler procedure with a shorter operation time than conventional stent placement.\nChiCTR2300074171 ClinicalTrials.gov ID:NCT06134557.",
    "authors": [
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.\nYangxin County People's Hospital, Binzhou, Shandong, China.",
            "firstname": "Tongfu",
            "initials": "T",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Weiying",
            "initials": "W",
            "lastname": "Zhong"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Donglin",
            "initials": "D",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Yangyang",
            "initials": "Y",
            "lastname": "Xu"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Maogui",
            "initials": "M",
            "lastname": "Li"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Jianfeng",
            "initials": "J",
            "lastname": "Zhuang"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Donghai",
            "initials": "D",
            "lastname": "Wang"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.",
            "firstname": "Wandong",
            "initials": "W",
            "lastname": "Su"
        },
        {
            "affiliation": "Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China. wangyunyan0618@126.com.",
            "firstname": "Yunyan",
            "initials": "Y",
            "lastname": "Wang"
        }
    ],
    "conclusions": "FD placement is a safe and effective treatment for IVADAs. It is also a simpler procedure with a shorter operation time than conventional stent placement.",
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1007/s00701-024-06398-z",
    "journal": "Acta neurochirurgica",
    "keywords": [
        "Aneurysm",
        "Coil",
        "Flow diverter",
        "Vertebral artery dissection"
    ],
    "methods": null,
    "publication_date": "2024-12-18",
    "pubmed_id": "39690339\n29880475\n31229575\n23418004\n29600915\n33906940\n28438894\n27916721\n32707547\n24524952\n28962011\n26780551\n39064207\n32526018\n25355814\n33986109\n26958407\n34689473\n26427829\n36081876\n37851516\n27417905\n30846433\n26491041\n35800087\n26684772\n30201581\n19199507\n18309525\n28133987\n27294446\n31798519\n31275237\n32792460\n23840616\n24895032",
    "results": "All 152 patients underwent successful endovascular therapy. Forty patients were treated with FDs-alone, and 112 were treated with conventional stent-asisted coiling (including 62 with double stents). The complete occlusion rate was 93.75% in the FD group and 93.61% in the conventional stent group (p\u2009=\u20090.979). The complication rate was 5.00% in the FD group and 8.93% in the conventional stent group (p\u2009=\u20090.653). The in-stent restenosis rate was 3.13% in the FD group and 5.32% in the conventional stent group (p\u2009=\u20090.615). The procedure duration was significantly shorter in the FD than conventional stent group (p\u2009=\u20090.034). After propensity score matching, 37 patients with FDs were successfully matched, and the procedure duration was still significantly shorter in the FD group (p\u2009=\u20090.042).",
    "title": "Treatment of unruptured intracranial vertebral artery dissection aneurysms with Flow Diverter compared with conventional stent-assisted coiling-a single-center study.",
    "xml": "<Element 'PubmedArticle' at 0x788506150bd0>"
}