{
    "abstract": "Sheehan's syndrome is a form of maternal hypopituitarism resulting from excessive blood loss during or after childbirth. This extensive bleeding may reduce blood flow to the pituitary gland, causing pituitary cell damage and death (necrosis). The incidence of Sheehan's syndrome has decreased in developed countries, whereas in developing countries, it remains a substantial cause of morbidity and mortality among at-risk populations.\nWe describe the case of a 59-year-old patient of mestizo ethnicity, with an unusual presentation of Sheehan's syndrome 38 years after postpartum hemorrhage that affected hormone secretion at the adenohypophysis. During hospitalization, central adrenal insufficiency, low free thyroxine levels, decreased pituitary gland size, hypogonadotropic hypogonadism, and growth hormone deficiency were noted. The patient was treated with hydrocortisone and levothyroxine, with satisfactory clinical progress and improvement in her quality of life.\nLate-onset Sheehan's syndrome is a progressive disease, with nonspecific symptoms, which leads to delayed diagnosis and, if not treated in time, may have fatal consequences.",
    "authors": [
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.\nDepartment of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.\nGenetics, Physiology, and Metabolism Research Group (GEFIME), Universidad Santiago de Cali, Santiago de Cali, Colombia.",
            "firstname": "Luis Miguel",
            "initials": "LM",
            "lastname": "Osorio-Toro"
        },
        {
            "affiliation": "Department of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.",
            "firstname": "Yessica Alejandra",
            "initials": "YA",
            "lastname": "Ordo\u00f1ez-Guzman"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.\nDepartment of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.\nGenetics, Physiology, and Metabolism Research Group (GEFIME), Universidad Santiago de Cali, Santiago de Cali, Colombia.",
            "firstname": "Jhon Fernando",
            "initials": "JF",
            "lastname": "Montenegro-Palacios"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.\nDepartment of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.\nGenetics, Physiology, and Metabolism Research Group (GEFIME), Universidad Santiago de Cali, Santiago de Cali, Colombia.",
            "firstname": "Jhon Herney",
            "initials": "JH",
            "lastname": "Quintana-Ospina"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.\nDepartment of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.\nGenetics, Physiology, and Metabolism Research Group (GEFIME), Universidad Santiago de Cali, Santiago de Cali, Colombia.",
            "firstname": "Julian Andres",
            "initials": "JA",
            "lastname": "Pacichana-Abadia"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia. jorgedaza.epidemiologia@gmail.com.\nHealth and Movement Research Group, Universidad Santiago de Cali, Santiago de Cali, Colombia. jorgedaza.epidemiologia@gmail.com.",
            "firstname": "Jorge Enrique",
            "initials": "JE",
            "lastname": "Daza-Arana"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.\nDepartment of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.",
            "firstname": "Hector Fabio",
            "initials": "HF",
            "lastname": "Escobar-Vargas"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.",
            "firstname": "Katherine",
            "initials": "K",
            "lastname": "Restrepo-Erazo"
        },
        {
            "affiliation": "Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Calle 5 # 62-00, Santiago de Cali, Colombia.\nDepartment of Research and Education, Cl\u00ednica de Occidente S.A., Santiago de Cali, Colombia.",
            "firstname": "Andr\u00e9s Felipe",
            "initials": "AF",
            "lastname": "Garc\u00eda-Ramos"
        }
    ],
    "conclusions": "Late-onset Sheehan's syndrome is a progressive disease, with nonspecific symptoms, which leads to delayed diagnosis and, if not treated in time, may have fatal consequences.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s13256-024-05000-5",
    "journal": "Journal of medical case reports",
    "keywords": [
        "Adrenal insufficiency",
        "Central hypothyroidism",
        "Hormones",
        "Postpartum hemorrhage",
        "Sheehan\u2019s syndrome"
    ],
    "methods": null,
    "publication_date": "2025-02-27",
    "pubmed_id": "40011977\n31880589\n16785150\n25648343\n29083621\n24394725\n28004764\n29681937\n9881893\n26485467\n37927363\n19697029\n21041170\n17255644\n34779875\n33962642\n33786491\n33343948\n35813355\n36824567\n33951030\n37772209\n33566997\n34162619\n35350058",
    "results": null,
    "title": "Late-onset Sheehan's syndrome: a major diagnostic challenge-a case report.",
    "xml": "<Element 'PubmedArticle' at 0x788503d19f80>"
}