{
    "abstract": "A prospective, randomized, open study was performed in 199 patients at the Leyenburg Hospital comparing amoxycillin/clavulanate (AMX/CL) with cefuroxime plus metronidazole (CR/MN) in the prophylaxis of infection following gynaecological surgery. AMX/CL was given as a single dose of 2200 mg i.v. at the start of the operation. CR/MN, 750/500 mg i.v. was administered 3 times within 24 h, beginning at the start of the operation. The study group consisted of patients undergoing either a vaginal hysterectomy, a vaginal hysterectomy with cysto/rectocele repair or a secondary caesarean section. There were no statistically significant differences in demographic characteristics, duration of surgery or anaesthetic method between the two groups. Postoperatively, 10.6% of patients developed a urinary tract infection, and febrile temperatures were found in 9.0% of patients. There were no statistically significant differences between the two treatment groups. Other complications were found in less than 1% of the study population, equally distributed between the two regimens. In this study there was a low overall percentage of infection after gynaecological surgery. AMX/CL was as effective as CR/MN as a perioperative prophylactic treatment and has the dual advantage of a single dose and lower cost.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynaecology, Municipal Hospital Leyenburg, The Hogue, The Netherlands.",
            "firstname": "M C",
            "initials": "MC",
            "lastname": "van der Linden"
        },
        {
            "affiliation": null,
            "firstname": "E J",
            "initials": "EJ",
            "lastname": "van Erp"
        },
        {
            "affiliation": null,
            "firstname": "G J",
            "initials": "GJ",
            "lastname": "Ruijs"
        },
        {
            "affiliation": null,
            "firstname": "J P",
            "initials": "JP",
            "lastname": "Holm"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1016/0028-2243(93)90178-f",
    "journal": "European journal of obstetrics, gynecology, and reproductive biology",
    "keywords": [],
    "methods": null,
    "publication_date": "1993-07-01",
    "pubmed_id": "8405642",
    "results": null,
    "title": "A prospective randomized study comparing amoxycillin/clavulanate with cefuroxime plus metronidazole for perioperative prophylaxis in gynaecological surgery.",
    "xml": "<Element 'PubmedArticle' at 0x788506c14c20>"
}