{
    "abstract": "Aberrant endometrial collagen I deposition during the implantation window impairs endometrial stromal cell (ESC) decidualization, which may contribute to lower pregnancy rate in endometriosis (EMs) patients with in vitro fertilization (IVF) treatment. However, the underlying mechanism of eutopic aberrant endometrium collagen I deposition in EMs remains unclear. In this study, we found increased endometrial collagen I and defective decidualization in the mid-secretory phase of EMs patients, while the level of eutopic ESCs' autophagy was decreased, which was an important mechanism of intracellular collagen degradation. Lower ESCs' autophagy level may cause the endometrial collagen I deposition in EMs. Furthermore, in vivo and in vitro studies showed that the extracellular vesicles derived from the ectopic ESCs of EMs patients (EMs-EVs) encapsulated higher PKM2 inhibited autophagy of the ESCs accompanied by an increase of collagen I. We also found that the constructed EMs-EVs",
    "authors": [
        {
            "affiliation": "Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
            "firstname": "Yuan",
            "initials": "Y",
            "lastname": "Zhu"
        },
        {
            "affiliation": "Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing, China.",
            "firstname": "Liang",
            "initials": "L",
            "lastname": "Gao"
        },
        {
            "affiliation": "Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
            "firstname": "Jingyu",
            "initials": "J",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
            "firstname": "Mengyun",
            "initials": "M",
            "lastname": "Li"
        },
        {
            "affiliation": "Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
            "firstname": "Jidong",
            "initials": "J",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address: zhou6jj@hotmail.com.",
            "firstname": "Jianjun",
            "initials": "J",
            "lastname": "Zhou"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.cellsig.2024.111523",
    "journal": "Cellular signalling",
    "keywords": [
        "Autophagy",
        "Collagen I",
        "Endometriosis",
        "Extracellular vesicle",
        "PKM2"
    ],
    "methods": null,
    "publication_date": "2024-11-26",
    "pubmed_id": "39586523",
    "results": null,
    "title": "Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis.",
    "xml": "<Element 'PubmedArticle' at 0x7885040dcb80>"
}