{
    "abstract": "BackgroundComplete atrioventricular septal defect (cAVSD) is the most common cardiac lesions associated with Down syndrome (DS). In DS, cAVSD repair is ideally performed before six months of age to prevent irreversible pulmonary artery hypertension (PAH). However, in developing countries, delayed repair is often unavoidable. We retrospectively analyzed the outcomes of cAVSD repair in DS patients presenting beyond six months of age.MethodBetween 2015 and 2019, 60 DS patients with cAVSD who underwent biventricular repair were reviewed. During the same time period 42 DS patients under 6 months of age underwent cAVSD repair. Their laboratory parameters and echocardiographic data were analyzed. Clinical findings as well as echocardiographic results at last follow-up were recorded.ResultMedian age of the cohort was eight months. There were 7/60 (11.7%) early mortalities due to right ventricular dysfunction secondary to persistent PAH (n\u2009=\u20094) and sepsis (n\u2009=\u20093). We found that right atrioventricular valve regurgitation (AVVR) grade (OR\u2009=\u20095.7, ",
    "authors": [
        {
            "affiliation": "Department of Cardiovascular and Thoracic Surgery, U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, India.",
            "firstname": "Kartik",
            "initials": "K",
            "lastname": "Patel"
        },
        {
            "affiliation": "Department of Cardiovascular and Thoracic Surgery, U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, India.",
            "firstname": "Chandrasekaran",
            "initials": "C",
            "lastname": "Ananthanarayanan"
        },
        {
            "affiliation": "Department of Cardiovascular and Thoracic Surgery, U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, India.",
            "firstname": "Trushar",
            "initials": "T",
            "lastname": "Gajjar"
        },
        {
            "affiliation": "Department of Cardiovascular and Thoracic Surgery, U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, India.",
            "firstname": "Amit",
            "initials": "A",
            "lastname": "Mishra"
        },
        {
            "affiliation": "Department of Paediatric Cardiology, U. N. Mehta Institute of Cardiology and Research Center, Ahmedabad, India.",
            "firstname": "Bhavik",
            "initials": "B",
            "lastname": "Champaneri"
        },
        {
            "affiliation": "Department of Cardiac Anesthesia, U. N. Mehta Institute of Cardiology and Research Center, Ahmedabad, India.",
            "firstname": "Jigar",
            "initials": "J",
            "lastname": "Surti"
        },
        {
            "affiliation": "Department of Research, U. N. Mehta Institute of Cardiology and Research Center, Ahmedabad, India.",
            "firstname": "Himani",
            "initials": "H",
            "lastname": "Pandya"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1177/21501351251322162",
    "journal": "World journal for pediatric & congenital heart surgery",
    "keywords": [
        "Down syndrome",
        "atrioventricular septal defects",
        "congenital heart disease",
        "pulmonary hypertension"
    ],
    "methods": null,
    "publication_date": "2025-04-03",
    "pubmed_id": "40179148",
    "results": null,
    "title": "Complete Atrioventricular Septal Defect Repair in Patients With Down Syndrome Presenting Beyond Six Months- A Single Center Experience.",
    "xml": "<Element 'PubmedArticle' at 0x788504885ee0>"
}