{
    "abstract": "Inorganic arsenic, a widespread environmental toxicant, significantly contributes to prostate injury. However, the exact cellular mechanisms remain unclear. This study explored the involvement of pyroptosis, apoptosis, and necroptosis (PANoptosis), and their interconnections in arsenic-induced prostate injury. Herein, by employing in vitro (WPMY-1 cells exposed to arsenic for 48\u202fh with or without reactive oxygen species (ROS) and mitochondrial ROS scavenger treatments) and in vivo (C57BL/6 mice were orally gavaged with arsenic and/or N-acetylcysteine for 90 consecutive days) models of arsenic-induced prostate injury and intervention, we demonstrated that sodium arsenite (NaAsO",
    "authors": [
        {
            "affiliation": "Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Yiping",
            "initials": "Y",
            "lastname": "Yang"
        },
        {
            "affiliation": "Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Xianglan",
            "initials": "X",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Urology, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Longxin",
            "initials": "L",
            "lastname": "Deng"
        },
        {
            "affiliation": "Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Yurun",
            "initials": "Y",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Yingxi",
            "initials": "Y",
            "lastname": "Mo"
        },
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Jiazhou",
            "initials": "J",
            "lastname": "Ye"
        },
        {
            "affiliation": "Department of Digestive Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, China.",
            "firstname": "Rong",
            "initials": "R",
            "lastname": "Liang"
        },
        {
            "affiliation": "The Second Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.",
            "firstname": "Yaxin",
            "initials": "Y",
            "lastname": "Qin"
        },
        {
            "affiliation": "Department of Urology, Guangxi Medical University Cancer Hospital, Nanning 530021, China. Electronic address: zqy628@163.com.",
            "firstname": "Qingyun",
            "initials": "Q",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, China. Electronic address: wangshan@sr.gxmu.edu.cn.",
            "firstname": "Shan",
            "initials": "S",
            "lastname": "Wang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 The Authors. Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.ecoenv.2025.118139",
    "journal": "Ecotoxicology and environmental safety",
    "keywords": [
        "Arsenic",
        "GSDME",
        "MLKL",
        "Mitochondrial dysfunction",
        "Prostatic PANoptosis"
    ],
    "methods": null,
    "publication_date": "2025-04-05",
    "pubmed_id": "40185034",
    "results": null,
    "title": "Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells.",
    "xml": "<Element 'PubmedArticle' at 0x7885054779c0>"
}