{
    "abstract": "Chinese herbal footbaths are an external therapy of traditional Chinese medicine that has been widely used to treat dysmenorrhea. This review aims to systematically evaluate its efficacy and safety for the treatment of dysmenorrhea.\nDatabases of PubMed, EMBASE, Cochrane Library, CIHAHL, Web of Science, Chinese National Knowledge Infrastructure(CNKI), Chinese Scientific Journals Database (VIP), Wanfang Database, China Biomedical Literature Database(CBM), and Chinese Biomedical Literature Service System (SinoMed) will be searched from the inception to September 30, 2020. The eligible randomized controlled trials (RCTs) will be identified and included. The primary outcomes include pain intensity measured by validated scales of visual analog scale, numeric rating scale, and response rate of symptom reduction. The secondary outcomes are scores on validated pain questionnaires, quality of life measured by SF-36 or other validated scales, and adverse events. Study selection, data extraction, and assessment of bias risk will be conducted by two reviewers independently. RevMan software (V.5.3.5) will be utilized to perform data synthesis. Subgroup and sensitivity analysis will be performed when necessary. The strength of the evidence will be evaluated with the Grading of Recommendations Assessment, Development and Evaluation System.\nA high-quality synthesis of current evidence of Chinese herbal footbaths for patients with dysmenorrhea will be provided in this study.\nThis systematic review will provide evidence of whether Chinese herbal footbaths are an effective and safe intervention for the treatment of dysmenorrhea.\nPROSPERO CRD42020188256.",
    "authors": [
        {
            "affiliation": "College of Clinical Medicine/College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
            "firstname": "Min",
            "initials": "M",
            "lastname": "Xiao"
        },
        {
            "affiliation": "Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, Otago, New Zealand.",
            "firstname": "Lizhou",
            "initials": "L",
            "lastname": "Liu"
        },
        {
            "affiliation": "Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, Otago, New Zealand.",
            "firstname": "Steve",
            "initials": "S",
            "lastname": "Tumilty"
        },
        {
            "affiliation": "West China Hospital, Sichuan University, South Renmin Road, Wu Hou District, Chengdu, Sichuan, China.",
            "firstname": "Dan",
            "initials": "D",
            "lastname": "Liu"
        },
        {
            "affiliation": "West China Hospital, Sichuan University, South Renmin Road, Wu Hou District, Chengdu, Sichuan, China.",
            "firstname": "Yanyan",
            "initials": "Y",
            "lastname": "You"
        },
        {
            "affiliation": "College of Clinical Medicine/College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
            "firstname": "Yunhui",
            "initials": "Y",
            "lastname": "Chen"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, China.",
            "firstname": "Songqi",
            "initials": "S",
            "lastname": "Tang"
        },
        {
            "affiliation": "College of Clinical Medicine/College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Huang"
        },
        {
            "affiliation": "Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, Otago, New Zealand.",
            "firstname": "George David",
            "initials": "GD",
            "lastname": "Baxter"
        }
    ],
    "conclusions": "This systematic review will provide evidence of whether Chinese herbal footbaths are an effective and safe intervention for the treatment of dysmenorrhea.",
    "copyrights": null,
    "doi": "10.1371/journal.pone.0250685\n10.1136/bmj.332.7550.1134\n10.1093/epirev/mxt009\n10.4103/0970-0218.62586\n10.4103/jfmpc.jfmpc_113_18\n10.2147/IJWH.S112768\n10.1016/j.jpain.2008.07.002\n10.1016/j.jpag.2013.06.018\n10.1093/humupd/dmv039\n10.1016/j.jpag.2013.11.008\n10.12688/f1000research.11682.1\n10.1002/14651858.CD002119.pub3\n10.1136/bmjopen-2018-026186\n10.1111/j.1447-0756.2008.00802.x\n10.3390/antiox9100994\n10.3390/ijerph17041191\n10.1002/14651858.CD001751.pub3\n10.18433/j3vw2f\n10.1016/j.jogc.2016.12.023\n10.1097/01.NPR.0000454984.19413.28\n10.1016/j.jep.2016.03.067\n10.1016/j.jep.2014.04.044\n10.1016/j.maturitas.2015.11.013\n10.1371/journal.pone.0072334\n10.1155/2014/296860\n10.1007/s00484-009-0300-x\n10.1589/jpts.29.1292\n10.1371/journal.pmed.1000097\n10.1002/jcph.250\n10.1111/j.1365-2702.2005.01121.x\n10.1097/00000542-200507000-00028\n10.1136/bmj.39489.470347.AD",
    "journal": "PloS one",
    "keywords": [],
    "methods": null,
    "publication_date": "2021-05-04",
    "pubmed_id": "33939740\n24695505\n16690671\n24284871\n20606943\n30234051\n27695366\n18722817\n24075089\n26346058\n24746919\n28944048\n16855988\n31248919\n19012707\n33076228\n32069859\n26224322\n24393558\n28625286\n25325520\n27060631\n24837303\n26857875\n24223693\n25431607\n20157740\n28878450\n19621072\n24374753\n16000093\n15983473\n8290681\n18436948",
    "results": "A high-quality synthesis of current evidence of Chinese herbal footbaths for patients with dysmenorrhea will be provided in this study.",
    "title": "Efficacy and safety of Chinese herbal footbaths for the treatment of dysmenorrhea: Protocol for a systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788504e4c540>"
}