{
    "abstract": "The hormonal changes in women influence creatine dynamics, emphasizing its potential importance during menstruation, pregnancy, postpartum, menopause, and postmenopause. Yet, limited research explores creatine's impact on female reproductive health at the population level. Our study investigated the relationship between dietary creatine intake and reproductive health indices in US women using data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). We extracted a dataset containing females aged 12\u2009years and above who provided details about their reproductive health and dietary habits. Daily creatine intake was quantified as a relative amount (mg per kg body mass) and did not include creatine from dietary supplements and pharmacological agents. A daily requirement for dietary creatine for healthy women was employed to classify respondents into two separate subpopulations: (1) suboptimal intake of creatine (<13\u2009mg per kg body mass per day) or (2) recommended intake (dietary creatine\u2009\u2265\u200913\u2009mg per kg body mass per day). A total of 4522 female participants from the NHANES study (age 44.5\u2009\u00b1\u200920.5\u2009years) provided data on their reproductive health and dietary intake. The average daily creatine intake for the group was 10.5\u2009\u00b1\u200910.8\u2009mg per kg body mass. The odds ratio for having irregular periods in women consuming \u226513\u2009mg of creatine per kg body mass daily (recommended intake) compared to those with suboptimal intake was 0.75 (95% CI, from 0.66 to 0.86), indicating a significant association between higher intake of dietary creatine and lower risk of oligomenorrhea (",
    "authors": [
        {
            "affiliation": "Applied Bioenergetics Lab, Faculty of Sport and PE University of Novi Sad Novi Sad Serbia.\nDepartment of Nutrition and Public Health University of Agder Kristiansand Norway.\nFaculty of Health Sciences University of Pecs Pecs Hungary.",
            "firstname": "Sergej M",
            "initials": "SM",
            "lastname": "Ostojic"
        },
        {
            "affiliation": "Department of Health and Nursing Sciences University of Agder Kristiansand Norway.",
            "firstname": "Tonje Holte",
            "initials": "TH",
            "lastname": "Stea"
        },
        {
            "affiliation": "The Ritchie Centre Hudson Institute of Medical Research Clayton Victoria Australia.\nDepartment of Obstetrics and Gynaecology Monash University Clayton Victoria Australia.",
            "firstname": "Stacey J",
            "initials": "SJ",
            "lastname": "Ellery"
        },
        {
            "affiliation": "Department of Exercise and Sport Science University of North Carolina Chapel Hill North Carolina USA.",
            "firstname": "Abbie E",
            "initials": "AE",
            "lastname": "Smith-Ryan"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.",
    "doi": "10.1002/fsn3.4135\n10.1186/s12884-020-03192-4\n10.1016/j.psj.2023.103166\n10.1146/annurev.nutr.27.061406.093621\n10.1111/1471-0528.14237\n10.1007/s00726-016-2199-y\n10.1016/s1083-3188(03)00154-2\n10.1007/s40279-015-0387-7\n10.23751/pn.v25i1.11595\n10.3390/nu15020429\n10.3390/nu13020490\n10.1159/000515916\n10.1093/advances/nmab111\n10.1159/000520818\n10.1016/j.jff.2023.105733\n10.1111/mcn.13474\n10.3390/nu14030586\n10.1093/biolre/ioad099\n10.1210/me.2013-1413\n10.3390/nu13030877\n10.1186/s12905-023-02476-z\n10.1186/s12905-021-01184-w\n10.3390/cells10112902\n10.1093/humrep/dey081\n10.2527/jas.2012-5610\n10.1152/physrev.2000.80.3.1107",
    "journal": "Food science & nutrition",
    "keywords": [
        "NHANES",
        "creatine",
        "dietary intake",
        "fetal macrosomia",
        "oligomenorrhea"
    ],
    "methods": null,
    "publication_date": "2024-07-26",
    "pubmed_id": "39055234\n32491509\n32883247\n37939584\n17430086\n27550725\n26898548\n27227232\n14597022\n26442916\n36678300\n33540766\n33895738\n34662902\n34763333\n36794361\n35276945\n37602666\n24678733\n33800439\n37340306\n33509179\n34831126\n29635630\n23463559\n10893433",
    "results": null,
    "title": "Association between dietary intake of creatine and female reproductive health: Evidence from NHANES 2017-2020.",
    "xml": "<Element 'PubmedArticle' at 0x7885043361b0>"
}