{
    "abstract": "We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6\u2009months after delivery. Endometrial histology suggested PSTT. Serum human chorionic gonadotropin (hCG) was 117\u2009mIU/mL and serum estradiol (E2) were 51\u2009pg/mL. She reported increased appetite, sweating, fatigue, and 7-kg weight loss within 3\u2009months. Blood samples showed a thyroid-stimulating hormone (TSH) level <0.01\u2009\u03bcIU/mL, FT3: 24.3\u2009pg/mL, FT4: 5.3\u2009ng/mL. The patient was diagnosed with hyperthyroidism. After thyroid function normalized, laparoscopic hysterectomy and bilateral salpingectomy were performed. Two years postsurgery, there was no recurrence, and thyroid function improved. The hCG produced from gestational trophoblastic disease has stronger TSH activity than that from gestational trophoblasts. However, in PSTT, the E2 level, which increases thyroid-binding proteins and suppresses elevated thyroid hormone levels, is low and may induce hyperthyroidism. In cases of suspected PSTT, thyroid function should be evaluated when hyperthyroid symptoms are present.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunky\u014d, Japan.",
            "firstname": "Sumire",
            "initials": "S",
            "lastname": "Ishii"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunky\u014d, Japan.",
            "firstname": "Takashi",
            "initials": "T",
            "lastname": "Hirayama"
        },
        {
            "affiliation": "Department of Pathology and Oncology, Faculty of Medicine, Juntendo University, Bunky\u014d, Japan.",
            "firstname": "Harumi",
            "initials": "H",
            "lastname": "Saeki"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunky\u014d, Japan.",
            "firstname": "Kazunari",
            "initials": "K",
            "lastname": "Fujino"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunky\u014d, Japan.",
            "firstname": "Yasuhisa",
            "initials": "Y",
            "lastname": "Terao"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunky\u014d, Japan.",
            "firstname": "Atsuo",
            "initials": "A",
            "lastname": "Itakura"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 Japan Society of Obstetrics and Gynecology.",
    "doi": "10.1111/jog.16193",
    "journal": "The journal of obstetrics and gynaecology research",
    "keywords": [
        "asialo hCG",
        "hyperthyroidism",
        "placental site trophoblastic tumor"
    ],
    "methods": null,
    "publication_date": "2024-12-26",
    "pubmed_id": "39722226",
    "results": null,
    "title": "A case of transient hyperthyroidism induced by placental site trophoblastic tumor.",
    "xml": "<Element 'PubmedArticle' at 0x788505439d00>"
}