{
    "abstract": "Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the development of atherosclerosis. Key metabolites and enzymes in sphingolipid metabolism influence the pathogenesis of atherosclerosis in a variety of ways, including inflammatory responses and oxidative stress. Thus, an investigation of sphingolipid metabolism-related metabolites and key enzymes may provide novel insights and treatment targets for atherosclerosis. This review discusses various mechanisms and research progress on the relationship between various sphingolipid metabolites, related enzymes, and atherosclerosis. Finally, we look into the future research direction of phytosphingolipids.",
    "authors": [
        {
            "affiliation": "National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.\nSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.",
            "firstname": "Fufangyu",
            "initials": "F",
            "lastname": "Zhao"
        },
        {
            "affiliation": "National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.",
            "firstname": "Mingyan",
            "initials": "M",
            "lastname": "Shao"
        },
        {
            "affiliation": "National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.",
            "firstname": "Mingrui",
            "initials": "M",
            "lastname": "Li"
        },
        {
            "affiliation": "National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.",
            "firstname": "Tianxing",
            "initials": "T",
            "lastname": "Li"
        },
        {
            "affiliation": "National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. yanfei_z@163.com.",
            "firstname": "Yanfei",
            "initials": "Y",
            "lastname": "Zheng"
        },
        {
            "affiliation": "Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, 255000, Shandong, China. 512649113@qq.com.",
            "firstname": "Wenlong",
            "initials": "W",
            "lastname": "Sun"
        },
        {
            "affiliation": "School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China. nicheng@bucm.edu.cn.",
            "firstname": "Cheng",
            "initials": "C",
            "lastname": "Ni"
        },
        {
            "affiliation": "National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. 700435@bucm.edu.cn.",
            "firstname": "Lingru",
            "initials": "L",
            "lastname": "Li"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s11658-024-00679-2",
    "journal": "Cellular & molecular biology letters",
    "keywords": [
        "Atherosclerosis",
        "Enzymes",
        "Metabolites",
        "Phytosphingolipids",
        "Sphingolipids"
    ],
    "methods": null,
    "publication_date": "2025-02-08",
    "pubmed_id": "39920588\n26892955\n27682885\n35237978\n32574973\n10195908\n35237979\n29546829\n33917744\n31420554\n25655639\n36411665\n38811775\n29165427\n13831944\n33772258\n34004484\n30890654\n11403420\n11085984\n10535965\n27055903\n16532372\n14670935\n15131591\n22717515\n17152923\n33738905\n36233252\n32576697\n17023427\n19416851\n29863195\n19648650\n16772288\n17340572\n21707511\n23579449\n24899305\n32694860\n21468641\n17194770\n21421810\n18218968\n9558480\n32476784\n30266560\n23845852\n37479181\n33158378\n34233172\n23075523\n36671005\n8823312\n29307517\n32980131\n33121744\n32067904\n29728014\n28280233\n27765765\n11116061\n12031266\n16611667\n20032291\n27973607\n32278039\n27100498\n29982602\n31672624\n27789842\n24630524\n28674269\n26260307\n33903284\n32387714\n15217913\n9763522\n32172624\n30937466\n22111752\n31150623\n30655217\n25295788\n27107674\n4585089\n25345524\n27422507\n14685263\n10544266\n16396678\n3093620\n19648608\n16508036\n21235823\n22580896\n19590047\n15545514\n3606727\n17805716\n7749869\n9812202\n16251722\n233765\n20814016\n7858911\n11686002\n9448918\n12383800\n19968738\n16141399\n11877368\n10946223\n9887164\n28724841\n21606363\n26268607\n20502008\n29550481\n24411702\n26921757\n21164103\n12069830\n36229882\n28878674\n25673082\n23640484\n20947824\n35836816\n16982942\n30188757\n35837598\n30559216\n20919643\n19190807\n35372499\n35218738\n29737246\n1590823\n7583534\n18565198\n23549085\n36197001\n38660786\n28056980\n19798445\n20037589\n33662400\n23426370\n32091078\n24817993\n19416652\n15590644\n37003301\n33558762\n33679742\n33558761\n33939982\n26603569\n24374347\n19506037\n30272329\n31722535\n31382484\n22071358\n18566297\n22538014\n33910580\n21115496\n22345277\n23593476\n27788151\n29128370\n19162217\n31797978\n30655318\n22234485\n31027508\n32424203\n34759313\n24439373\n35623356\n30691322\n18941821\n14731113\n26262576\n25575593\n31273070\n37956922\n37419220\n24177187\n37301511\n28936777\n36334778\n15723652\n37001191",
    "results": null,
    "title": "Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis.",
    "xml": "<Element 'PubmedArticle' at 0x788504eb7380>"
}