{
    "abstract": "Osteoarthritis (OA) is a degenerative joint disease characterized by the metabolic dysfunction of chondrocytes. A promising therapeutic strategy for OA involves suppressing the catabolism of the chondrocyte and promoting its anabolism to restore joint homeostasis. Here, it is demonstrated that Catalpol, a natural compound, can promote chondrocyte anabolic and proliferation, while inhibiting the catabolic activities and oxidative stress, thereby maintaining the dynamic balance of the extracellular matrix and alleviating inflammation-induced cartilage damage. Mechanistically, it has been discovered that Catalpol acts as a direct inhibitor of heat shock protein 90\u03b2 (Hsp90\u03b2), and the amino acids ASP88, THR179, ASP49, and ASN46 of N-terminal domain-Hsp90\u03b2 are confirmed as the binding sites for Catalpol. Knockdown of Hsp90\u03b2 in primary chondrocytes demonstrates a similar biological effect as Catalpol treatment. Moreover, to develop a nanoparticle-based interventional platform for OA management, biodegradable mesoporous silica nanoparticles (bMSN) are prepared to load Catalpol (Ca-bMSN). The engineered Ca-bMSN is able to penetrate into the chondrocytes, prolong retention in the joint space, and mitigate OA progression. These findings shed light on a potential mechanism by which Catalpol modulates chondrocyte metabolism, offering a promising therapeutic strategy for OA treatment.",
    "authors": [
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.\nNortheast Asia Institute Research of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Zhenwei",
            "initials": "Z",
            "lastname": "Zhou"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Binghua",
            "initials": "B",
            "lastname": "Zhang"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Lang",
            "initials": "L",
            "lastname": "Liu"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Jie",
            "initials": "J",
            "lastname": "Yang"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Yuting",
            "initials": "Y",
            "lastname": "Wang"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Cheng",
            "initials": "C",
            "lastname": "Lv"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "He",
            "initials": "H",
            "lastname": "Zhang"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Yuchi",
            "initials": "Y",
            "lastname": "Wei"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Zhanliang",
            "initials": "Z",
            "lastname": "Jiang"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Zeyu",
            "initials": "Z",
            "lastname": "Peng"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Daqing",
            "initials": "D",
            "lastname": "Zhao"
        },
        {
            "affiliation": "College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Xiangyang",
            "initials": "X",
            "lastname": "Leng"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Xiangyan",
            "initials": "X",
            "lastname": "Li"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Hang",
            "initials": "H",
            "lastname": "Su"
        },
        {
            "affiliation": "Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.\nNortheast Asia Institute Research of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, 130000, China.",
            "firstname": "Haisi",
            "initials": "H",
            "lastname": "Dong"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Advanced Science published by Wiley\u2010VCH GmbH.",
    "doi": "10.1002/advs.202503909",
    "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
    "keywords": [
        "Catalpol",
        "Hsp90\u03b2",
        "bMSN",
        "chondrocyte metabolism",
        "osteoarthritis"
    ],
    "methods": null,
    "publication_date": "2025-04-25",
    "pubmed_id": "40277849",
    "results": null,
    "title": "Inhibition of Heat Shock Protein 90\u03b2 by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation-Induced Cartilage Injuries in Osteoarthritis.",
    "xml": "<Element 'PubmedArticle' at 0x788503134130>"
}