{
    "abstract": "Extracorporeal membrane oxygenation (ECMO) is increasingly applied as rescue-therapy for patients with severe acute respiratory distress syndrome (ARDS). Here, we evaluate the effect of different configuration strategies (venovenous vs. venoarterial vs. veno-venoarterial) on the outcome. From 2006 to 2008, 30 patients received ECMO for severe ARDS. Patients were divided into three groups according to the configuration: veno-venous (vv; n = 11), venoarterial (va; n=8) or veno-venoarterial (vva; n = 11). Data were prospectively collected and endpoint was 30-day mortality. To identify independent risk factors, univariate analysis was performed for clinical parameters, such as age, body mass index, gender, configuration, low-pH, oxygenation index (pO(2)/FiO(2)) and underlying disease. Thirty-day mortality was 53% (n = 16) for all comers: 63% (n = 7) died in the vv-group, 75% (n = 6) in the va-group and 27% (n = 3) in the vva-group. Although univariate analysis could not rule out a significant predictor for the outcome, there was a trend visible to decreased mortality in the vva-group when compared to vv- and va-groups (27% vs. 63% vs. 75%; P = 0.057). ECMO provides a survival benefit in patients when considering a predicted mortality rate of 80% in ARDS. The configuration mode appears to impact the outcome as the veno-venoarterial appears to further improve the survival in this subset of patients.",
    "authors": [
        {
            "affiliation": "Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.",
            "firstname": "Frederik",
            "initials": "F",
            "lastname": "St\u00f6hr"
        },
        {
            "affiliation": null,
            "firstname": "Maximilian Y",
            "initials": "MY",
            "lastname": "Emmert"
        },
        {
            "affiliation": null,
            "firstname": "Mario L",
            "initials": "ML",
            "lastname": "Lachat"
        },
        {
            "affiliation": null,
            "firstname": "Reto",
            "initials": "R",
            "lastname": "Stocker"
        },
        {
            "affiliation": null,
            "firstname": "Marco",
            "initials": "M",
            "lastname": "Maggiorini"
        },
        {
            "affiliation": null,
            "firstname": "Volkmar",
            "initials": "V",
            "lastname": "Falk"
        },
        {
            "affiliation": null,
            "firstname": "Markus J",
            "initials": "MJ",
            "lastname": "Wilhelm"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1510/icvts.2010.258384",
    "journal": "Interactive cardiovascular and thoracic surgery",
    "keywords": [],
    "methods": null,
    "publication_date": "2011-02-10",
    "pubmed_id": "21303865",
    "results": null,
    "title": "Extracorporeal membrane oxygenation for acute respiratory distress syndrome: is the configuration mode an important predictor for the outcome?",
    "xml": "<Element 'PubmedArticle' at 0x7885033cbe70>"
}