{
    "abstract": "Neonatal thrombocytopenia (NTCP) is a common hematological disorder whose platelet count falls below the normal limit\u00a0of 150 x 10\nThe prevalence of NTCP was approximately 1.02% (111/10,936). Lack of antenatal care was found in\u00a012 (30%) neonates with EO-NTCP vs. 10 (12.5%)\u00a0neonates without EO-NTCP (p = 0.02). Neonates with EO-NTCP were more likely to have experienced\u00a0intrauterine growth restriction (5 (37.5%) vs. 5 (6.3%), p < 0.001)\u00a0and oligohydramnios (5 (12.5%) vs. 0 (0%), p = 0.003). Neonates who developed EO-NTCP were more likely to be admitted to the NICU (34 (85%) vs. 35 (43.8%), p < 0.001) and receive\u00a0antibiotics (22 (55%) vs. 25 (31.3%), p = 0.012). Also, neonates with EO-NTCP were more frequently diagnosed with neonatal sepsis (7 (17.5%) vs. 3 (3.8%), p = 0.015)\u00a0and more likely to receive\u00a0platelet transfusions (15 (37.5% vs. 1 (1.3%), p < 0.001). They also had a higher median length of hospital stay\u00a0(13 (interquartile range (IQR) 3-28) vs. 4\u00a0(IQR 2-9) days, p = 0.006). The mortality rates of neonates with EO-NTCP and those without were 6 (15%) vs. 2 (2.5%) neonates (p = 0.016). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of UC CBC were 62.50%, 97.50%, 20.40%, and 99.61%, respectively.\nThe prevalence of EO-NTCP in King Abdulaziz Medical City is comparable to international and national figures, and it\u00a0is associated with preceding maternal comorbidities, serious neonatal morbidity, and even mortality. Therefore, proper antenatal care is vital in preventing maternal and neonatal morbidities, including the risks of NTCP and its\u00a0related\u00a0complications. With high NPV, using UC CBC as a universal screening method could assist in safely discharging newborns. However, because of its low sensitivity, a comprehensive clinical examination with confirmatory laboratory tests are still\u00a0the cornerstone in diagnosing EO-NTCP. Future trials should aim to study the cost-effectiveness of universal UC CBC and the long-term outcomes of infants diagnosed with EO-NTCP.",
    "authors": [
        {
            "affiliation": "Pediatrics, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Western Region, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.\nCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.",
            "firstname": "Mohammed Y",
            "initials": "MY",
            "lastname": "Al-Hindi"
        },
        {
            "affiliation": "College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.",
            "firstname": "Sherin A",
            "initials": "SA",
            "lastname": "Qari"
        },
        {
            "affiliation": "College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.",
            "firstname": "Wed A",
            "initials": "WA",
            "lastname": "Fatani"
        },
        {
            "affiliation": "College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.",
            "firstname": "Raneem M",
            "initials": "RM",
            "lastname": "Alshaban"
        },
        {
            "affiliation": "College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.",
            "firstname": "Nooran S",
            "initials": "NS",
            "lastname": "Felemban"
        },
        {
            "affiliation": "College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.",
            "firstname": "Jood M",
            "initials": "JM",
            "lastname": "Altowairqi"
        },
        {
            "affiliation": "Pediatrics, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Western Region, Jeddah, SAU.\nResearch and Development, King Abdullah International Medical Research Center, Jeddah, SAU.\nCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.",
            "firstname": "Mansour A",
            "initials": "MA",
            "lastname": "AlQurashi"
        }
    ],
    "conclusions": "The prevalence of EO-NTCP in King Abdulaziz Medical City is comparable to international and national figures, and it\u00a0is associated with preceding maternal comorbidities, serious neonatal morbidity, and even mortality. Therefore, proper antenatal care is vital in preventing maternal and neonatal morbidities, including the risks of NTCP and its\u00a0related\u00a0complications. With high NPV, using UC CBC as a universal screening method could assist in safely discharging newborns. However, because of its low sensitivity, a comprehensive clinical examination with confirmatory laboratory tests are still\u00a0the cornerstone in diagnosing EO-NTCP. Future trials should aim to study the cost-effectiveness of universal UC CBC and the long-term outcomes of infants diagnosed with EO-NTCP.",
    "copyrights": "Copyright \u00a9 2023, Al-Hindi et al.",
    "doi": "10.7759/cureus.50503",
    "journal": "Cureus",
    "keywords": [
        "complete blood count",
        "diagnostic test accuracy",
        "neonatal",
        "sensitivity",
        "specificity",
        "thrombocytopenia",
        "umbilical cord"
    ],
    "methods": null,
    "publication_date": "2024-01-15",
    "pubmed_id": "38222232\n30044242\n24665958\n34033425\n34309308\n21835709\n28395365\n21566570\n15711036\n23519382\n9192764\n18433954\n19841111\n23233627\n23078538\n22988382\n9531342\n27704515\n21314921\n23687553\n33391958\n32963925\n34877230",
    "results": "The prevalence of NTCP was approximately 1.02% (111/10,936). Lack of antenatal care was found in\u00a012 (30%) neonates with EO-NTCP vs. 10 (12.5%)\u00a0neonates without EO-NTCP (p = 0.02). Neonates with EO-NTCP were more likely to have experienced\u00a0intrauterine growth restriction (5 (37.5%) vs. 5 (6.3%), p < 0.001)\u00a0and oligohydramnios (5 (12.5%) vs. 0 (0%), p = 0.003). Neonates who developed EO-NTCP were more likely to be admitted to the NICU (34 (85%) vs. 35 (43.8%), p < 0.001) and receive\u00a0antibiotics (22 (55%) vs. 25 (31.3%), p = 0.012). Also, neonates with EO-NTCP were more frequently diagnosed with neonatal sepsis (7 (17.5%) vs. 3 (3.8%), p = 0.015)\u00a0and more likely to receive\u00a0platelet transfusions (15 (37.5% vs. 1 (1.3%), p < 0.001). They also had a higher median length of hospital stay\u00a0(13 (interquartile range (IQR) 3-28) vs. 4\u00a0(IQR 2-9) days, p = 0.006). The mortality rates of neonates with EO-NTCP and those without were 6 (15%) vs. 2 (2.5%) neonates (p = 0.016). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of UC CBC were 62.50%, 97.50%, 20.40%, and 99.61%, respectively.",
    "title": "Accuracy of Umbilical Cord Complete Blood Count in Detecting Early-Onset Neonatal Thrombocytopenia.",
    "xml": "<Element 'PubmedArticle' at 0x7885025486d0>"
}