{
    "abstract": "High neighborhood deprivation is linked to increased cancer and overall mortality. Prior studies demonstrated higher inflammation in people from high deprivation areas. The area deprivation index (ADI) is a composite measure of income, education, employment, and housing, which quantifies neighborhood deprivation. We used the All of Us dataset to test whether inflammation, measured via c-reactive protein (CRP), albumin, and the neutrophil-to-lymphocyte ratio (NLR), differs by ADI in cancer survivors.\nOur sample included individuals with a history of lung, breast, prostate, and colorectal cancer, filtered for the presence of the inflammatory biomarkers. We used quartiles of ADI based on 3-digit zip code and biomarkers from electronic health records. We estimated the association between ADI and inflammation using adjusted logistic regression (n\u2009=\u2009690 for CRP; n\u2009=\u20094242 for albumin; n\u2009=\u20095183 for NLR).\nThe sample had a mean age of 66.2\u2009\u00b1\u200910.1\u2009years, 63.0% were female, and 86.8% were White. Mean CRP (11.5\u2009\u00b1\u200917.5\u2009mg/L) and NLR (3.6\u2009\u00b1\u20092.2) indicated moderate to high inflammation. In the fully adjusted model, there were 2.04 (95% CI:1.02, 4.11) and 2.17 higher odds (95% CI:1.16, 4.13) of elevated CRP when comparing quartile 4 and quartile 3, respectively, to the lowest ADI quartile. Regression models were not significant for albumin or NLR.\nArea deprivation is associated with CRP, a marker of stress that may lead to a higher risk of chronic diseases among cancer survivors. Future studies using a sample of cancer survivors with a wider range of ADI may help to strengthen this association.",
    "authors": [
        {
            "affiliation": "Cancer Health Equity and Career Development Program, University of Illinois Chicago, Chicago, Illinois, USA.",
            "firstname": "Cecily A",
            "initials": "CA",
            "lastname": "Byrne"
        },
        {
            "affiliation": "Kinesiology and Nutrition Department, University of Illinois Chicago, Chicago, Illinois, USA.",
            "firstname": "Vanessa M",
            "initials": "VM",
            "lastname": "Oddo"
        },
        {
            "affiliation": "School of Public Health, University of Illinois Chicago, Chicago, Illinois, USA.",
            "firstname": "Evgenia",
            "initials": "E",
            "lastname": "Karayeva"
        },
        {
            "affiliation": "School of Public Health, University of Illinois Chicago, Chicago, Illinois, USA.",
            "firstname": "Greg",
            "initials": "G",
            "lastname": "Kopetsky"
        },
        {
            "affiliation": "School of Public Health, University of Illinois Chicago, Chicago, Illinois, USA.",
            "firstname": "Sage",
            "initials": "S",
            "lastname": "Kim"
        }
    ],
    "conclusions": "Area deprivation is associated with CRP, a marker of stress that may lead to a higher risk of chronic diseases among cancer survivors. Future studies using a sample of cancer survivors with a wider range of ADI may help to strengthen this association.",
    "copyrights": "\u00a9 2025 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.",
    "doi": "10.1002/cam4.70784\n10.3322/caac.21820\n10.1002/cncr.31943\n10.1155/2011/107497\n10.2105/ajph.93.7.1137\n10.1177/1062860617753063\n10.7326/M13-2946\n10.1001/jamanetworkopen.2021.39593\n10.1111/j.1749-6632.1999.tb08103.x\n10.1111/pedi.12361\n10.1007/s11524-016-0034-0\n10.1097/PSY.0b013e31817b8ee4\n10.5888/pcd11.140090\n10.1371/journal.pone.0045419\n10.1016/j.envint.2022.107164\n10.1016/j.bbi.2020.07.017\n10.1172/JCI18921\n10.3390/nu12051517\n10.1016/j.bbi.2024.03.034\n10.1186/1475-2891-9-69\n10.1080/19420862.2021.1893888\n10.1038/s41467-021-20935-9\n10.4149/BLL_2021_078\n10.1001/jamaoncol.2017.2319\n10.1093/ajcn/nqy328\n10.3390/biomedicines11092444\n10.1161/01.cir.0000053730.47739.3c\n10.1093/jnci/dju124\n10.1056/NEJMp1802313\n10.1016/j.annepidem.2018.11.008\n10.1016/j.tjnut.2023.12.041\n10.1371/journal.pone.0112361\n10.1016/j.annepidem.2019.07.015\n10.1093/jn/nxz021\n10.1016/j.jjcc.2018.11.010\n10.1016/j.healthplace.2013.09.005\n10.1007/s11524-008-9288-5\n10.1097/PPO.0000000000000058\n10.1016/j.amepre.2016.09.026\n10.1016/j.amepre.2016.09.010\n10.1016/j.amepre.2007.09.021\n10.1093/ajcn/87.6.1883\n10.2105/AJPH.2014.302113\n10.1016/j.currproblcancer.2007.02.002\n10.1016/j.cell.2011.02.013\n10.1038/s41598-024-57410-6\n10.3389/fimmu.2022.1008674",
    "journal": "Cancer medicine",
    "keywords": [
        "albumin",
        "area deprivation index",
        "cancer survivorship",
        "c\u2010reactive protein",
        "inflammation",
        "neutrophil\u2010to\u2010lymphocyte ratio"
    ],
    "methods": null,
    "publication_date": "2025-04-05",
    "pubmed_id": "40186349\n38230766\n30768779\n22496688\n12835199\n29357679\n25437404\n34919133\n10681886\n11668773\n26783014\n27000125\n18606725\n25078567\n23049799\n35255255\n31412182\n32688027\n12813013\n32456138\n38552920\n21176210\n33691596\n33526794\n34161115\n28796857\n30850836\n37760885\n12551853\n24875653\n29949490\n30563729\n38158187\n25375150\n31481293\n31006809\n30600191\n24100238\n18481182\n25098282\n27989295\n27989293\n18083446\n18541581\n25211721\n17543948\n7560851\n24466505\n21376230\n38627404\n36544783",
    "results": "The sample had a mean age of 66.2\u2009\u00b1\u200910.1\u2009years, 63.0% were female, and 86.8% were White. Mean CRP (11.5\u2009\u00b1\u200917.5\u2009mg/L) and NLR (3.6\u2009\u00b1\u20092.2) indicated moderate to high inflammation. In the fully adjusted model, there were 2.04 (95% CI:1.02, 4.11) and 2.17 higher odds (95% CI:1.16, 4.13) of elevated CRP when comparing quartile 4 and quartile 3, respectively, to the lowest ADI quartile. Regression models were not significant for albumin or NLR.",
    "title": "Area Deprivation and Clinical Biomarkers of Inflammation in Cancer Survivors of the National Institutes of Health All of Us Research Program.",
    "xml": "<Element 'PubmedArticle' at 0x788506561440>"
}