{
    "abstract": "High-quality cardiopulmonary resuscitation is crucial for the survival of patients experiencing cardiac arrest, but the effect of the chest compression release velocity (CCRV) has not been well studied. The aim of this study was to evaluate the effect of the CCRV on cerebral perfusion pressure (CePP) in an experimental study of porcine cardiac arrest.\nA ventricular fibrillation (VF)-induced experimental model of cardiac arrest was established in 16 pigs. The study subjects were randomized into a high-CCRV (400 mm/sec) group and a low-CCRV (300 mm/sec) group. Six minutes after VF induction, all the study subjects underwent four minutes of chest compression followed by 20 minutes of advanced cardiovascular life support, including the intravenous administration of epinephrine. Defibrillation was provided after 24 minutes of resuscitation. The primary outcome was CePP, which was calculated as the difference between the mean arterial pressure and intracranial pressure. The Wilcoxon rank-sum test was used to compare two groups in each resuscitation phase, and a linear mixed model was used analyze the interaction effect of group and resuscitation phase.\nEach of the eight subjects in the high-CCRV group and low-CCRV group were finally analyzed. The CEPP was highest at 10 ~ 12 minutes after VF in the low-CCRV group, with a mean (95% CI) of 14.9 (0.2-29.7) mmHg, and at 12 ~ 14 minutes after VF in the high-CCRV group, with a mean (95% CI) of 18.2 (3.8-32.6) mmHg. Compared with the low-CCRV group, the high-CCRV group had a greater CePP throughout the entire resuscitation phase, but there was no significant difference in the linear mixed model.\nIn the porcine model of VF-induced cardiac arrest, there was a significant difference in CePP between the low-CCRV and high-CCRV groups. Further investigations should be performed to develop the resuscitation protocol to optimize brain perfusion.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "Sang Hun",
            "initials": "SH",
            "lastname": "Kim"
        },
        {
            "affiliation": null,
            "firstname": "Ki Hong",
            "initials": "KH",
            "lastname": "Kim"
        },
        {
            "affiliation": null,
            "firstname": "Yoonjic",
            "initials": "Y",
            "lastname": "Kim"
        },
        {
            "affiliation": null,
            "firstname": "Yoon Ha",
            "initials": "YH",
            "lastname": "Joo"
        },
        {
            "affiliation": "Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute.",
            "firstname": "Hyun Jeong",
            "initials": "HJ",
            "lastname": "Kang"
        },
        {
            "affiliation": "Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute.",
            "firstname": "Chae Yeong",
            "initials": "CY",
            "lastname": "An"
        },
        {
            "affiliation": null,
            "firstname": "Young Sun",
            "initials": "YS",
            "lastname": "Ro"
        },
        {
            "affiliation": null,
            "firstname": "Ki Jeong",
            "initials": "KJ",
            "lastname": "Hong"
        },
        {
            "affiliation": null,
            "firstname": "Kyoung Jun",
            "initials": "KJ",
            "lastname": "Song"
        },
        {
            "affiliation": null,
            "firstname": "Sang",
            "initials": "S",
            "lastname": "Do Shin"
        }
    ],
    "conclusions": "In the porcine model of VF-induced cardiac arrest, there was a significant difference in CePP between the low-CCRV and high-CCRV groups. Further investigations should be performed to develop the resuscitation protocol to optimize brain perfusion.",
    "copyrights": "Copyright \u00a9 2025 by the Shock Society.",
    "doi": "10.1097/SHK.0000000000002604",
    "journal": "Shock (Augusta, Ga.)",
    "keywords": [
        "Cardiac arrest",
        "Cardiopulmonary resuscitation",
        "Cerebral perfusion",
        "Chest compression release velocity",
        "Porcine experimental study"
    ],
    "methods": null,
    "publication_date": "2025-04-23",
    "pubmed_id": "40267501",
    "results": "Each of the eight subjects in the high-CCRV group and low-CCRV group were finally analyzed. The CEPP was highest at 10 ~ 12 minutes after VF in the low-CCRV group, with a mean (95% CI) of 14.9 (0.2-29.7) mmHg, and at 12 ~ 14 minutes after VF in the high-CCRV group, with a mean (95% CI) of 18.2 (3.8-32.6) mmHg. Compared with the low-CCRV group, the high-CCRV group had a greater CePP throughout the entire resuscitation phase, but there was no significant difference in the linear mixed model.",
    "title": "Effect of chest compression release velocity on cerebral perfusion pressure in porcine cardiac arrest model.",
    "xml": "<Element 'PubmedArticle' at 0x788503b3a250>"
}