{
    "abstract": "In trauma patients, the recognition of fibrinolysis phenotypes has led to a re-evaluation of the risks and benefits of antifibrinolytic therapy (AF). Many cardiac patients also receive AF, but the distribution of fibrinolytic phenotypes in that population is unknown. The purpose of this hypothesis-generating study was to fill that gap.\nSeventy-eight cardiac surgery patients were retrospectively reviewed. Phenotypes were defined as hypofibrinolytic (LY30 <0.8%), physiologic (0.8%-3.0%), and hyperfibrinolytic (>3%) based on thromboelastogram.\nThe population was 65\u2009\u00b1\u200910-years old, 74% male, average body mass index of 29\u2009\u00b1\u20095\u2009kg/m\nThis is the first description of the prevalence of three different fibrinolytic phenotypes and their potential influence on cardiac surgery patients. The use of AF was associated with increased morbidity, but because of the small sample size and treatment allocation bias, additional confirmatory studies are necessary. We hope these present findings open the dialog on whether it is safe to administer AFs to cardiac surgery patients who are normo- or hypofibrinolytic.",
    "authors": [
        {
            "affiliation": "Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nUniversity of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Matthew S",
            "initials": "MS",
            "lastname": "Sussman"
        },
        {
            "affiliation": "Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nUniversity of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Eva M",
            "initials": "EM",
            "lastname": "Urrechaga"
        },
        {
            "affiliation": "Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nUniversity of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Alessia C",
            "initials": "AC",
            "lastname": "Cioci"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Rahul S",
            "initials": "RS",
            "lastname": "Iyengar"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Tyler J",
            "initials": "TJ",
            "lastname": "Herrington"
        },
        {
            "affiliation": "Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nUniversity of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Emily L",
            "initials": "EL",
            "lastname": "Ryon"
        },
        {
            "affiliation": "Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nUniversity of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Nicholas",
            "initials": "N",
            "lastname": "Namias"
        },
        {
            "affiliation": "Division of Cardiothoracic Surgery, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "David L",
            "initials": "DL",
            "lastname": "Galbut"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nDivision of Cardiothoracic Surgery, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Tomas A",
            "initials": "TA",
            "lastname": "Salerno"
        },
        {
            "affiliation": "Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.\nUniversity of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.",
            "firstname": "Kenneth G",
            "initials": "KG",
            "lastname": "Proctor"
        }
    ],
    "conclusions": "This is the first description of the prevalence of three different fibrinolytic phenotypes and their potential influence on cardiac surgery patients. The use of AF was associated with increased morbidity, but because of the small sample size and treatment allocation bias, additional confirmatory studies are necessary. We hope these present findings open the dialog on whether it is safe to administer AFs to cardiac surgery patients who are normo- or hypofibrinolytic.",
    "copyrights": "\u00a9 2021 Wiley Periodicals LLC.",
    "doi": "10.1111/jocs.15406",
    "journal": "Journal of cardiac surgery",
    "keywords": [
        "aminocaproic acid",
        "thromboelastogram",
        "tranexamic acid"
    ],
    "methods": null,
    "publication_date": "2021-02-16",
    "pubmed_id": "33586229",
    "results": "The population was 65\u2009\u00b1\u200910-years old, 74% male, average body mass index of 29\u2009\u00b1\u20095\u2009kg/m",
    "title": "Do all cardiac surgery patients benefit from antifibrinolytic therapy?",
    "xml": "<Element 'PubmedArticle' at 0x788505a109f0>"
}