{
    "abstract": "Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). Existing evidence for the effectiveness of NPWT on postoperative wounds healing by primary closure remains uncertain.\nTo assess the effects of NPWT for preventing SSI in wounds healing through primary closure, and to assess the cost-effectiveness of NPWT in wounds healing through primary closure.\nIn June 2019, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries and references of included studies, systematic reviews and health technology reports. There were no restrictions on language, publication date or study setting.\nWe included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another type of NPWT.\nAt least two review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, assessment using the Cochrane 'Risk of bias' tool, and quality assessment according to Grading of Recommendations, Assessment, Development and Evaluations methodology.\nIn this third update, we added 15 new randomised controlled trials (RCTs) and three new economic studies, resulting in a total of 44 RCTs (7447 included participants) and five economic studies. Studies evaluated NPWT in the context of a wide range of surgeries including orthopaedic, obstetric, vascular and general procedures. Economic studies assessed NPWT in orthopaedic, obstetric and general surgical settings. All studies compared NPWT with standard dressings. Most studies had unclear or high risk of bias for at least one key domain. Primary outcomes Four studies (2107 participants) reported mortality. There is low-certainty evidence (downgraded twice for imprecision) showing no clear difference in the risk of death after surgery for people treated with NPWT (2.3%) compared with standard dressings (2.7%) (risk ratio (RR) 0.86; 95% confidence interval (CI) 0.50 to 1.47; I\nPeople experiencing primary wound closure of their surgical wound and treated prophylactically with NPWT following surgery probably experience fewer SSI than people treated with standard dressings (moderate-certainty evidence). There is no clear difference in number of deaths or wound dehiscence between people treated with NPWT and standard dressings (low-certainty evidence). There are also no clear differences in secondary outcomes where all evidence was low or very low-certainty. In caesarean section in obese women and surgery for lower limb fracture, there is probably little difference in quality of life scores (moderate-certainty evidence). Most evidence on pain is very low-certainty, but there is probably no difference in pain between NPWT and standard dressings after surgery for lower limb fracture (moderate-certainty evidence). Assessments of cost-effectiveness of NPWT produced differing results in different indications. There is a large number of ongoing studies, the results of which may change the findings of this review. Decisions about use of NPWT should take into account surgical indication and setting and consider evidence for all outcomes.",
    "authors": [
        {
            "affiliation": "Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.",
            "firstname": "Gill",
            "initials": "G",
            "lastname": "Norman"
        },
        {
            "affiliation": "Oxford Trauma, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, UK.",
            "firstname": "En Lin",
            "initials": "EL",
            "lastname": "Goh"
        },
        {
            "affiliation": "Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.",
            "firstname": "Jo C",
            "initials": "JC",
            "lastname": "Dumville"
        },
        {
            "affiliation": "Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.",
            "firstname": "Chunhu",
            "initials": "C",
            "lastname": "Shi"
        },
        {
            "affiliation": "West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Zhenmi",
            "initials": "Z",
            "lastname": "Liu"
        },
        {
            "affiliation": "NIHR Clinical Research Facility, Great Ormond Street Hospital, London, UK.",
            "firstname": "Laura",
            "initials": "L",
            "lastname": "Chiverton"
        },
        {
            "affiliation": "Chermside Community Health Centre, Community and Oral Health Directorate, Brisbane, Australia.",
            "firstname": "Monica",
            "initials": "M",
            "lastname": "Stankiewicz"
        },
        {
            "affiliation": "School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester, UK.",
            "firstname": "Adam",
            "initials": "A",
            "lastname": "Reid"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.",
    "doi": "10.1002/14651858.CD009261.pub5\n10.1111/iwj.12848\n10.1007/s00266-018-1095-0\n10.1002/14651858.CD004287.pub3\n10.1007/s11695-010-0328-3\n10.1002/14651858.CD011278.pub2\n10.1111/iwj.12232\n10.1002/14651858.CD009261.pub3\n10.1002/14651858.CD009261.pub3\n10.1002/14651858.CD009261.pub4",
    "journal": "The Cochrane database of systematic reviews",
    "keywords": [],
    "methods": null,
    "publication_date": "2020-05-02",
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    "results": null,
    "title": "Negative pressure wound therapy for surgical wounds healing by primary closure.",
    "xml": "<Element 'PubmedArticle' at 0x788502a6ff60>"
}