{
    "abstract": "Cleansing of the vulva and perineum is recommended during preparation for vaginal delivery, and special attention is paid to cleansing before episiotomy because episiotomy is known to increase the risk of perineal wound infection and/or dehiscence. However, the optimal method of perineal cleansing has not been established, including the choice of antiseptic agent. To address this issue, we designed a randomized controlled trial to examine whether skin preparation with chlorhexidine-alcohol is superior to povidone-iodine for the prevention of perineal wound infection after vaginal delivery.\nIn this multicenter randomized controlled trial, term pregnant women who plan to deliver vaginally after episiotomy will be enrolled. The participants will be randomly assigned to use antiseptic agents for perineal cleansing (povidone-iodine or chlorhexidine-alcohol). The primary outcome is superficial or deep perineal wound infection within 30 days after vaginal delivery. The secondary outcomes are the length of hospital stay, physician office visits, or hospital readmission for infection-related complications, endometritis, skin irritations, and allergic reactions.\nThis study will be the first randomized controlled trial aiming to determine the optimal antiseptic agent for the prevention of perineal wound infections after vaginal delivery.\nClinicalTrials.gov NCT05122169. First submitted date on 8 November 2021. First posted date on 16 November 2021.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.",
            "firstname": "Young Mi",
            "initials": "YM",
            "lastname": "Jung"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.",
            "firstname": "Seung Mi",
            "initials": "SM",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.",
            "firstname": "So Yeon",
            "initials": "SY",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.",
            "firstname": "Jin Hoon",
            "initials": "JH",
            "lastname": "Chung"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.",
            "firstname": "Hye-Sung",
            "initials": "HS",
            "lastname": "Won"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Ewha Womans University Seoul Hospital, College of Medicine, Ewha Womans University, Seoul, South Korea.",
            "firstname": "Kyung A",
            "initials": "KA",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Ewha Womans University Seoul Hospital, College of Medicine, Ewha Womans University, Seoul, South Korea.",
            "firstname": "Mi Hye",
            "initials": "MH",
            "lastname": "Park"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, Seoul, South Korea.\nDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.",
            "firstname": "Geum Joon",
            "initials": "GJ",
            "lastname": "Cho"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, Seoul, South Korea.\nDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.",
            "firstname": "Min-Jeong",
            "initials": "MJ",
            "lastname": "Oh"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.\nDepartment of Obstetrics and Gynecology, Korea University Anam Hospital, Seoul, South Korea.",
            "firstname": "Eun Saem",
            "initials": "ES",
            "lastname": "Choi"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.\nDepartment of Obstetrics and Gynecology, Korea University Anam Hospital, Seoul, South Korea.",
            "firstname": "Ki Hoon",
            "initials": "KH",
            "lastname": "Ahn"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.\nDepartment of Obstetrics and Gynecology, Korea University Anam Hospital, Seoul, South Korea.",
            "firstname": "Soon-Cheol",
            "initials": "SC",
            "lastname": "Hong"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.",
            "firstname": "Ji-Hee",
            "initials": "JH",
            "lastname": "Sung"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.",
            "firstname": "Cheong-Rae",
            "initials": "CR",
            "lastname": "Roh"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, South Korea.",
            "firstname": "Sun Min",
            "initials": "SM",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, South Korea.",
            "firstname": "Byoung Jae",
            "initials": "BJ",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.",
            "firstname": "Hyeon Ji",
            "initials": "HJ",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.\nDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.",
            "firstname": "Kyung Joon",
            "initials": "KJ",
            "lastname": "Oh"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.",
            "firstname": "Subeen",
            "initials": "S",
            "lastname": "Hong"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.",
            "firstname": "In Yang",
            "initials": "IY",
            "lastname": "Park"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. jsparkmd@snu.ac.kr.",
            "firstname": "Joong Shin",
            "initials": "JS",
            "lastname": "Park"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023. The Author(s).",
    "doi": "10.1186/s13063-023-07101-w\n10.1002/14651858.CD008534.pub2\n10.1007/s00404-019-05165-1\n10.1159/000293161\n10.1111/j.0730-7659.2005.00373.x\n10.1186/1471-2393-1-1\n10.1016/j.ajog.2012.12.025\n10.1007/s00192-014-2401-2\n10.1002/14651858.CD007462.pub5\n10.1002/14651858.CD007892.pub7\n10.1056/nejm199605093341901\n10.1086/657134",
    "journal": "Trials",
    "keywords": [
        "Antiseptic",
        "Perineal infection",
        "Randomized controlled trial",
        "Vaginal delivery"
    ],
    "methods": null,
    "publication_date": "2023-02-23",
    "pubmed_id": "36810189\n19445799\n21833968\n31004221\n1885090\n16582142\n16128977\n11375051\n23262251\n24807426\n32580252\n32335895\n8606715\n20969449",
    "results": null,
    "title": "The Skin Antiseptic agents at Vaginal dElivery (SAVE) trial: study protocol for a randomized controlled trial.",
    "xml": "<Element 'PubmedArticle' at 0x788503150450>"
}