{
    "abstract": "This study aims to investigate the association between antimicrobial resistance genes and virulence factors in ST11 and non-ST11 types of CR-KP in bloodstream infections in the intensive care unit, providing a theoretical basis for infection control and clinical diagnosis and treatment.\nFrom January 2021 to June 2023, samples of \nAmong the 85 CR-KP cases, 61.18% were of the ST11 type, predominantly of the KL64 capsular type; non-ST11 types were mainly ST15, accounting for 25.88%, predominantly of the KL5 capsular type. The carriage rates of virulence genes such as \nThe study reveals that ST11 type CR-KP in intensive care unit bloodstream infections exhibits stronger resistance and higher virulence compared to non-ST11 types, posing significant challenges to clinical treatment. Thus, strict control over the use of carbapenem antibiotics is essential to prevent the spread of resistant plasmids.",
    "authors": [
        {
            "affiliation": "Clinical Laboratory of Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang Province, People's Republic of China.",
            "firstname": "Yanye",
            "initials": "Y",
            "lastname": "Tu"
        },
        {
            "affiliation": "Clinical Laboratory of Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang Province, People's Republic of China.",
            "firstname": "Hui",
            "initials": "H",
            "lastname": "Gao"
        },
        {
            "affiliation": "Clinical Laboratory of Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang Province, People's Republic of China.",
            "firstname": "Rongqing",
            "initials": "R",
            "lastname": "Zhao"
        },
        {
            "affiliation": "Clinical Laboratory of Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang Province, People's Republic of China.",
            "firstname": "Jiliang",
            "initials": "J",
            "lastname": "Yan"
        },
        {
            "affiliation": "School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, People's Republic of China.",
            "firstname": "Diyu",
            "initials": "D",
            "lastname": "Wu"
        }
    ],
    "conclusions": "The study reveals that ST11 type CR-KP in intensive care unit bloodstream infections exhibits stronger resistance and higher virulence compared to non-ST11 types, posing significant challenges to clinical treatment. Thus, strict control over the use of carbapenem antibiotics is essential to prevent the spread of resistant plasmids.",
    "copyrights": "\u00a9 2024 Tu et al.",
    "doi": "10.2147/IDR.S478156\n10.1186/s12890-023-02394-8\n10.1186/s12879-019-4498-x\n10.1099/jmm.0.001462\n10.1016/j.jsps.2022.03.007\n10.1111/1469-0691.12275\n10.1186/s13756-022-01055-5\n10.1016/j.micpath.2022.105519\n10.1038/s41591-020-0825-4\n10.1093/jac/dkq431\n10.1007/s10096-017-3131-4\n10.2147/idr.s387742\n10.1556/030.2023.02186\n10.1016/j.ijantimicag.2023.106747\n10.2147/idr.S418523\n10.1111/joim.13007\n10.3389/fmicb.2023.1325077\n10.1128/aac.04265-14\n10.1128/cmr.00117-13\n10.1002/nmi2.42\n10.1007/s10096-010-0896-0\n10.1179/1973947812y.0000000017\n10.1128/spectrum.01107-22\n10.1016/j.diagmicrobio.2010.10.013\n10.1128/aac.02523-14\n10.1128/spectrum.04165-22\n10.3389/fmicb.2023.1272173\n10.3390/antibiotics11050596\n10.1016/j.micpath.2022.105746\n10.1186/s12866-022-02532-y\n10.3760/cma.j.cn112150-20210730-00732\n10.1016/j.isci.2022.104428\n10.1128/iai.00093-17\n10.3389/fcimb.2020.556654\n10.1016/j.ijantimicag.2024.107131",
    "journal": "Infection and drug resistance",
    "keywords": [
        "Non-ST11 CR-KP",
        "ST11 CR-KP",
        "bloodstream infections",
        "intensive care unit",
        "resistance genes",
        "virulence genes"
    ],
    "methods": null,
    "publication_date": "2024-09-23",
    "pubmed_id": "39309066\n36978069\n31703559\n34889726\n35812137\n23841705\n35074014\n35483557\n32284589\n21131324\n29282569\n36312437\n38047929\n36758779\n37589017\n31677303\n38098668\n22273027\n25246390\n24696435\n25356342\n20213255\n23040691\n36622219\n21396529\n24982067\n36971550\n38033569\n35625240\n36064103\n35468722\n34749482\n35663037\n28717029\n33777826\n38432605",
    "results": "Among the 85 CR-KP cases, 61.18% were of the ST11 type, predominantly of the KL64 capsular type; non-ST11 types were mainly ST15, accounting for 25.88%, predominantly of the KL5 capsular type. The carriage rates of virulence genes such as ",
    "title": "Analysis of the Association Between Antimicrobial Resistance Genes and Virulence Factors in ST11 and Non-ST11 CR-KP Bloodstream Infections in the Intensive Care Unit.",
    "xml": "<Element 'PubmedArticle' at 0x788504d6bec0>"
}