{
    "abstract": "Anticoagulant therapy prevents thrombosis and thromboembolic events in patients with mechanical heart valves. Bridging anticoagulation around the time of birth represents a unique challenge. Few retrospective reviews or case series exist examining peripartum outcomes with bridging anticoagulation.\nReview of peripartum and postpartum anticoagulation management, with a focus on postpartum complications.\nDesign: case series, single centre.\nRoyal Brisbane and Women's Hospital, Australia between 1 January, 2000, and 1 August, 2022.\nall pregnant women with mechanical heart valves (any type) who birthed.\nintrapartum and postpartum haemorrhage, thrombosis, thromboembolic complications, cardiac events, readmission, and maternal death.\nThere were 18 women, with 23 births. Sixteen births were via caesarean section (70%). Fourteen women (61%) experienced at least one significant haemorrhagic complication, one woman required a peripartum hysterectomy, one woman experienced atrial fibrillation, and one had a valvular thromboembolic complication. No maternal cerebral thromboses or maternal deaths were recorded.\nWomen with mechanical heart valves who undergo bridging anticoagulation are associated with significant maternal morbidity. Most postpartum haemorrhagic complications were associated with bridging unfractionated heparin infusions in the first postnatal week. Bridging anticoagulation practices varied widely. Ongoing pooled data are required to inform evidence-based guidelines for postpartum anticoagulation management.",
    "authors": [
        {
            "affiliation": "Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.",
            "firstname": "Lily",
            "initials": "L",
            "lastname": "Aboud"
        },
        {
            "affiliation": "Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.",
            "firstname": "Helen",
            "initials": "H",
            "lastname": "Tanner"
        },
        {
            "affiliation": "Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Australia.\nAustralian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, Australia.",
            "firstname": "William",
            "initials": "W",
            "lastname": "Parsonage"
        },
        {
            "affiliation": "Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.\nFaculty of Medicine, The University of Queensland, Brisbane, Australia.",
            "firstname": "Karin",
            "initials": "K",
            "lastname": "Lust"
        },
        {
            "affiliation": "Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.\nFaculty of Medicine, The University of Queensland, Brisbane, Australia.",
            "firstname": "Leonie",
            "initials": "L",
            "lastname": "Callaway"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.",
    "doi": "10.1111/ajo.13897",
    "journal": "The Australian & New Zealand journal of obstetrics & gynaecology",
    "keywords": [
        "anticoagulants",
        "cardiovascular",
        "mechanical prosthetic heart valves",
        "pregnancy",
        "pregnancy complications"
    ],
    "methods": null,
    "publication_date": "2024-11-05",
    "pubmed_id": "39497491",
    "results": "There were 18 women, with 23 births. Sixteen births were via caesarean section (70%). Fourteen women (61%) experienced at least one significant haemorrhagic complication, one woman required a peripartum hysterectomy, one woman experienced atrial fibrillation, and one had a valvular thromboembolic complication. No maternal cerebral thromboses or maternal deaths were recorded.",
    "title": "Haemorrhagic and thromboembolic outcomes in pregnant patients with mechanical heart valves who undergo interruption of anticoagulation for birth - A case series.",
    "xml": "<Element 'PubmedArticle' at 0x7885042f6a70>"
}