{
    "abstract": "There are few data on the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) in cities over 1000 m above sea level (masl).\nTo describe the clinical characteristics and mortality of patients with COVID-19 treated at a high complexity hospital in Bogot\u00e1, Colombia, at 2640 masl.\nThis was an observational study of a cohort including 5161 patients with confirmed COVID-19 infection from 19 March 2020 to 30 April 2021. Demographic data, laboratory values, comorbidities, oxygenation indices, and clinical outcomes were collected. Data were compared between survivors and nonsurvivors. An independent predictive model was performed for mortality and invasive mechanical ventilation (IMV) using classification and regression trees (CART).\nThe median cohort age was 66 years (interquartile range (IQR) 53-77), with 1305 patients dying (25%) and 3856 surviving (75%). The intensive care unit (ICU) received 1223 patients (24%). Of 898 patients who received IMV, 613 (68%) of them perished. The ratio of partial pressure arterial oxygen (PaO\nAmong more than 5000 patients with COVID-19 treated in our hospital, mortality at hospital discharge was 25%. Older age, low S/F ratio, and high LDH at admission were predictors of mortality.",
    "authors": [
        {
            "affiliation": "Critical and Intensive Care Medicine, Hospital Universitario Mayor-M\u00e9deri, Bogot\u00e1, Colombia. drrodriguezl@hotmail.com.\nGrupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia. drrodriguezl@hotmail.com.",
            "firstname": "David Rene",
            "initials": "DR",
            "lastname": "Rodriguez Lima"
        },
        {
            "affiliation": "Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia.",
            "firstname": "\u00c1ngela Mar\u00eda",
            "initials": "\u00c1M",
            "lastname": "Pinz\u00f3n Rond\u00f3n"
        },
        {
            "affiliation": "Critical and Intensive Care Medicine, Hospital Universitario Mayor-M\u00e9deri, Bogot\u00e1, Colombia.",
            "firstname": "Cristhian",
            "initials": "C",
            "lastname": "Rubio Ramos"
        },
        {
            "affiliation": "Critical and Intensive Care Medicine, Hospital Universitario Mayor-M\u00e9deri, Bogot\u00e1, Colombia.",
            "firstname": "Dar\u00edo Isa\u00edas",
            "initials": "DI",
            "lastname": "Pinilla Rojas"
        },
        {
            "affiliation": "Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia.",
            "firstname": "Maria Jos\u00e9",
            "initials": "MJ",
            "lastname": "Ni\u00f1o Orrego"
        },
        {
            "affiliation": "Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia.",
            "firstname": "Mateo Andr\u00e9s",
            "initials": "MA",
            "lastname": "D\u00edaz Quiroz"
        },
        {
            "affiliation": "Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia.",
            "firstname": "Nicol\u00e1s",
            "initials": "N",
            "lastname": "Molano-Gonz\u00e1lez"
        },
        {
            "affiliation": "Planning Department, Hospital Universitario Mayor-M\u00e9deri, Bogot\u00e1, Colombia.",
            "firstname": "Jorge Enrique",
            "initials": "JE",
            "lastname": "Ceballos Quintero"
        },
        {
            "affiliation": "Planning Department, Hospital Universitario Mayor-M\u00e9deri, Bogot\u00e1, Colombia.",
            "firstname": "Alex Francisco",
            "initials": "AF",
            "lastname": "Arroyo Santos"
        },
        {
            "affiliation": "Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia.",
            "firstname": "\u00c1ngela Mar\u00eda",
            "initials": "\u00c1M",
            "lastname": "Ruiz Sternberg"
        }
    ],
    "conclusions": "Among more than 5000 patients with COVID-19 treated in our hospital, mortality at hospital discharge was 25%. Older age, low S/F ratio, and high LDH at admission were predictors of mortality.",
    "copyrights": "\u00a9 2022. The Author(s).",
    "doi": "10.1186/s12245-022-00426-4\n10.1016/j.wem.2019.04.006\n10.1016/j.recesp.2012.06.027\n10.1111/jtm.12017\n10.1016/j.medin.2017.08.006\n10.1161/CIRCULATIONAHA.108.819250\n10.1371/journal.pone.0164483\n10.1002/oby.20800\n10.18632/aging.101057\n10.1016/j.diabres.2020.108463\n10.1590/S0036-36342013000100013\n10.1371/journal.pone.0074220\n10.1016/j.resp.2020.103443\n10.4269/ajtmh.20-1027\n10.1371/journal.pone.0245055\n10.1089/ham.2020.0173\n10.1038/s41598-021-83971-x\n10.1016/j.resp.2020.103464\n10.1089/ham.2020.0114\n10.1152/ajplung.90415.2008\n10.1016/j.jep.2019.112470\n10.1038/pr.2015.27\n10.4269/ajtmh.20-1465\n10.14814/phy2.14922\n10.14814/phy2.14615\n10.1183/13993003.00524-2020\n10.1016/S0140-6736(20)31189-2\n10.1136/bmjopen-2020-043651\n10.1371/journal.pone.0246030\n10.7326/M20-3905\n10.1016/S2213-2600(20)30079-5\n10.1007/s00134-020-06294-x\n10.1001/jama.2020.5394\n10.1001/jamainternmed.2020.3539\n10.7326/M20-5327\n10.7326/M20-2911\n10.1186/s12931-021-01756-2\n10.1016/j.jaci.2020.04.006\n10.1001/jama.2020.6775\n10.1016/j.aucc.2020.10.009\n10.1164/rccm.202006-2405OC\n10.1038/s41598-021-86676-3\n10.1371/journal.pone.0249964\n10.3389/fmed.2021.670195\n10.1186/s40001-020-00432-3\n10.1515/cclm-2020-0198\n10.1016/j.immuni.2020.06.017\n10.3389/fimmu.2020.01708\n10.2478/jtim-2018-0009\n10.3748/wjg.v25.i33.4970\n10.1186/s12967-020-02374-0\n10.1186/s13054-020-03374-8\n10.1186/s12931-020-01428-7\n10.3389/fphys.2021.676782\n10.1016/j.jss.2018.03.035\n10.1186/s11658-020-00228-7\n10.1080/00365513.2020.1768587\n10.1371/journal.pone.0241955\n10.1016/j.ajem.2020.11.025\n10.1136/postgradmedj-2020-139542\n10.1515/cclm-2021-0156",
    "journal": "International journal of emergency medicine",
    "keywords": [
        "Altitude",
        "COVID-19",
        "Clinical outcomes",
        "Mortality",
        "SARS-CoV-2"
    ],
    "methods": null,
    "publication_date": "2022-05-22",
    "pubmed_id": "35597911\n31248818\n23068616\n23809076\n28919307\n19635973\n27812092\n24890677\n27705903\n32971150\n23370263\n24058530\n32333993\n33124543\n33444357\n33054403\n33623105\n32447057\n32716669\n19592460\n31862407\n25665060\n25194138\n33372652\n34110706\n33340275\n32269088\n32442528\n33040020\n33507974\n32960645\n32105632\n33211135\n32250385\n32667669\n33460330\n32687717\n34098967\n32294485\n32320003\n33250401\n33119402\n33795768\n22797452\n27623033\n34003821\n34055842\n32746929\n32119647\n32610079\n32754163\n29607304\n31543687\n32434518\n33198786\n32620118\n34122145\n29907227\n32528540\n32449374\n33201896\n33246860\n33452143\n33675191",
    "results": "The median cohort age was 66 years (interquartile range (IQR) 53-77), with 1305 patients dying (25%) and 3856 surviving (75%). The intensive care unit (ICU) received 1223 patients (24%). Of 898 patients who received IMV, 613 (68%) of them perished. The ratio of partial pressure arterial oxygen (PaO",
    "title": "Clinical characteristics and mortality associated with COVID-19 at high altitude: a cohort of 5161 patients in Bogot\u00e1, Colombia.",
    "xml": "<Element 'PubmedArticle' at 0x788503f8cea0>"
}