{
    "abstract": "Evaluate the efficiency of an autologous whole blood clot (WBC) matrix on diabetic foot ulcers (DFU), and analyse its immune response with near-infrared spectroscopy (NIRS) and pH measurement.\nThree patients were treated with a WBC. The matrix was produced at the point of care, using a WBC system. A WBC gel was formed and applied onto the wounds. The gel remained in place with primary and secondary dressings.\nWound-size reduction was 70% after two applications, 97.6% after three applications, and 90.9% after four applications. The NIRS skeletal muscle oxygen saturation (StO2) increased in all cases.\nThe autologous matrix was efficient in treating DFU. The wound area surface reduced after each application and wound healing was achieved in all cases. More studies are needed to understand the benefits of using a WBC matrix on DFU.\nEvaluar la eficacia de una matriz aut\u00f3loga en el tratamiento de \u00falceras de pie diab\u00e9tico (UPD) de dif\u00edcil cicatrizaci\u00f3n, y analizar la respuesta inmune a la aplicaci\u00f3n de la matriz con un esc\u00e1ner de infrarrojo cercano (NIRS, por sus siglas en ingl\u00e9s) y un medidor de pH d\u00e9rmico.\nTres pacientes fueron tratados con una matriz de co\u00e1gulo de sangre completa (WBC, por sus siglas en ingl\u00e9s) aut\u00f3loga. La matriz se realiz\u00f3 en el punto de atenci\u00f3n, mezclando la sangre del paciente con una suspensi\u00f3n coloidal de gluconato de calcio/caol\u00edn, e inyect\u00e1ndola en una bandeja de coagulaci\u00f3n. Se form\u00f3 un gel de WBC y se aplic\u00f3 a las heridas. El gel de WBC se mantuvo en su lugar con ap\u00f3sitos primarios y secundarios.\nHubo una reducci\u00f3n del tama\u00f1o de las UPD de 70% tras dos aplicaciones, 97,6% despu\u00e9s de tres aplicaciones, y 90,9% tras cuatro aplicaciones. El NIRS midi\u00f3 un aumento en la saturaci\u00f3n de ox\u00edgeno tisular. No hubo reacciones adversas.\nLa matriz aut\u00f3loga fue eficaz en el tratamiento de las UPD. La superficie de las UPD se redujo despu\u00e9s de cada aplicaci\u00f3n y se logr\u00f3 el cierre completo de las heridas. Se necesitan m\u00e1s ensayos cl\u00ednicos para comprender mejor los beneficios de la matriz de WBC en UPD.\nRedDress Ltd. (Pardes-Hanna, Israel) proporcion\u00f3 los suministros y materiales del estudio. Bennett Health Inc. ayud\u00f3 con el desarrollo del protocolo y capacit\u00f3 al personal sobre la aplicaci\u00f3n del producto para co\u00e1gulos sangu\u00edneos. JA es accionista de Bennett Health Inc. No hubo inter\u00e9s financiero para ninguno de los investigadores o participantes.",
    "authors": [
        {
            "affiliation": "Presidenta, Wound Care Plus Research and Education Center, San Juan, Puerto Rico.\nPresidenta, Puerto Rico Wound Healing Society, Puerto Rico.\nVicepresidenta, Confederaci\u00f3n Multidisciplinar Latinoamericana de Heridas, Estomas e Incontinencias (COMLHEI).\nProfesora, Universidad Ana G. M\u00e9ndez, San Juan, Puerto Rico.",
            "firstname": "Leticia",
            "initials": "L",
            "lastname": "Vallejo"
        },
        {
            "affiliation": "Presidenta, Bennett Health, Inc.",
            "firstname": "Jean",
            "initials": "J",
            "lastname": "Achterberg"
        }
    ],
    "conclusions": "The autologous matrix was efficient in treating DFU. The wound area surface reduced after each application and wound healing was achieved in all cases. More studies are needed to understand the benefits of using a WBC matrix on DFU.",
    "copyrights": null,
    "doi": "10.12968/jowc.2020.29.LatAm_sup_3.24",
    "journal": "Journal of wound care",
    "keywords": [
        "NIRS",
        "angiogenesis",
        "angiog\u00e9nesis",
        "autologous matrix",
        "diabetic foot ulcer",
        "matriz aut\u00f3loga",
        "medidor de pH",
        "pH measurement",
        "\u00falcera de pie diab\u00e9tico"
    ],
    "methods": "Three patients were treated with a WBC. The matrix was produced at the point of care, using a WBC system. A WBC gel was formed and applied onto the wounds. The gel remained in place with primary and secondary dressings.",
    "publication_date": "2020-12-01",
    "pubmed_id": "33249991",
    "results": "Wound-size reduction was 70% after two applications, 97.6% after three applications, and 90.9% after four applications. The NIRS skeletal muscle oxygen saturation (StO2) increased in all cases.",
    "title": "Uso de una matriz aut\u00f3loga en el tratamiento de \u00falceras de pie diab\u00e9tico, con espectroscopia de infrarrojo cercano y medidor de pH d\u00e9rmico.",
    "xml": "<Element 'PubmedArticle' at 0x788500be6430>"
}