{
    "abstract": "Intestinal enterochromaffin (EC) cell hyperplasia and increased 5-hydroxytryptamine (5-HT) availability play key roles in the pathogenesis of abdominal hypersensitivity of irritable bowel syndrome (IBS). This study aims to study the effect of quercetin on visceral pain and 5-HT availability in postinflammatory IBS (PI-IBS) rats. PI-IBS model rats were administered quercetin by gavage at doses of 5, 10, and 20\u2009mg/kg for 14 days. Compared with normal rats, the visceral pain threshold of PI-IBS rats was markedly decreased and the abdominal motor response to colon distension was markedly increased. The EC cell count and 5-HT level, as well as tryptophan hydroxylase (TPH) protein, were all significantly elevated in PI-IBS rats, while the 5-HT reuptake transporter (serotonin transporter) was reduced. Genes that are responsible for enteroendocrine cell differentiation, that is, ",
    "authors": [
        {
            "affiliation": "1 Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou, China.",
            "firstname": "Hong-Yan",
            "initials": "HY",
            "lastname": "Qin"
        },
        {
            "affiliation": "2 College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou, China.",
            "firstname": "Kai-Hong",
            "initials": "KH",
            "lastname": "Zang"
        },
        {
            "affiliation": "1 Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou, China.\n3 School of Pharmaceutical, Lanzhou University, Lanzhou, China.",
            "firstname": "Xiao",
            "initials": "X",
            "lastname": "Zuo"
        },
        {
            "affiliation": "1 Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou, China.",
            "firstname": "Xin-An",
            "initials": "XA",
            "lastname": "Wu"
        },
        {
            "affiliation": "4 Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.",
            "firstname": "Zhao-Xiang",
            "initials": "ZX",
            "lastname": "Bian"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1089/jmf.2018.4264",
    "journal": "Journal of medicinal food",
    "keywords": [],
    "methods": null,
    "publication_date": "2019-03-29",
    "pubmed_id": "30920336",
    "results": null,
    "title": "Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon.",
    "xml": "<Element 'PubmedArticle' at 0x78850440f9c0>"
}