{
    "abstract": "Preventing venous thromboembolism (VTE) in obstetrics remains challenging, with cases still occurring despite preventive measures. The aim of this study is to investigate the underlying causes by analyzing potential issues in current postpartum VTE prevention strategies in China. This retrospective study was conducted in our hospital from May 2021 to August 2024. VTE risk was assessed using the Chinese Expert Consensus on VTE Prevention and Treatment during Pregnancy and Puerperium (Chinese Consensus), and preventive measures were implemented accordingly. Clinical variables, timing of prophylaxis, and the predictive accuracy of the Chinese Consensus were analyzed. The VTE group had higher D-dimer levels and longer hospital stays and shorter gestational ages (P\u2009<\u20090.05). Significant differences were observed in postpartum hemorrhage (PPH), premature birth, autoimmune diseases, and cesarean delivery (P\u2009<\u20090.05). Despite 65.4% receiving thromboprophylaxis, 25.2% developed VTE, with higher incidences in those without prophylaxis. Pneumatic therapy and LMWH were effective in high-risk patients (P\u2009<\u20090.05). Early VTE occurred 6\u00a0h postpartum, with 41.8% within 48\u00a0h. Most preventive measures were initiated at 24-48\u00a0h postpartum, potentially delaying optimal protection. The ROC analysis showed an AUC of 0.497 (P\u2009=\u20090.937), indicating limited predictive efficacy of the Chinese Consensus. Current postpartum VTE prevention is inadequate, as some at-risk patients still miss the opportunity for pneumatic therapy and LMWH anticoagulation after delivery. Initiating LMWH prophylaxis 24\u00a0h postpartum appears to be delayed. The predictive ability of the Chinese Consensus for assessing VTE risk is limited. Future research is essential to optimize prevention strategies and reduce the incidence of postpartum VTE.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology Intensive Care Unit, West China Women's and Children's Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, China.\nKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.",
            "firstname": "Yonghui",
            "initials": "Y",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology Intensive Care Unit, West China Women's and Children's Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, China.\nKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.",
            "firstname": "Fei",
            "initials": "F",
            "lastname": "Xiao"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology Intensive Care Unit, West China Women's and Children's Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, China.",
            "firstname": "Ji",
            "initials": "J",
            "lastname": "He"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology Intensive Care Unit, West China Women's and Children's Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, China.",
            "firstname": "XingSheng",
            "initials": "X",
            "lastname": "Xue"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology Intensive Care Unit, West China Women's and Children's Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, China.",
            "firstname": "Yangting",
            "initials": "Y",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology Intensive Care Unit, West China Women's and Children's Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, China. zhusha_hxey@163.com.\nKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China. zhusha_hxey@163.com.",
            "firstname": "Sha",
            "initials": "S",
            "lastname": "Zhu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1038/s41598-025-95790-5",
    "journal": "Scientific reports",
    "keywords": [
        "Chinese consensus",
        "Low molecular weight heparin",
        "Postpartum",
        "Thromboprophylaxis",
        "Venous thromboembolism"
    ],
    "methods": null,
    "publication_date": "2025-04-01",
    "pubmed_id": "40164739\n26780741\n35792687\n34030656\n36897147\n18180616\n20052816\n29939939\n36822707\n39174149\n31866276\n37620792\n36088049\n29532451\n38145574\n37996129\n30939900\n38229588\n30482767\n36644567\n35498021\n37976060",
    "results": null,
    "title": "Analysis on the causes of unsatisfactory prevention effect of postpartum VTE in Chinese women.",
    "xml": "<Element 'PubmedArticle' at 0x78850577e070>"
}