{
    "abstract": "3% chloroprocaine (CP) has been reported as the common local anesthetic used in pregnant women undergoing urgent cesarean delivery during labor analgesia period. However, 0.75% ropivacaine is considered a promising and effective alternative. Therefore, we conducted a randomized controlled trial to compare the effectiveness and safety of 0.75% ropivacaine with 3% chloroprocaine for extended epidural anesthesia in pregnant women.\nWe conducted a double-blind, randomized, controlled, single-center study from November 1, 2022, to April 30, 2023. We selected forty-five pregnant women undergoing urgent cesarean delivery during labor analgesia period and randomized them to receive either 0.75% ropivacaine or 3% chloroprocaine in a 1:1 ratio. The primary outcome was the time to loss of cold sensation at the T4 level.\nThere was a significant difference between the two groups in the time to achieve loss of cold sensation (303, 95%CI 255 to 402\u00a0S vs. 372, 95%CI 297 to 630\u00a0S, p\u2009=\u20090.024). There was no significant difference the degree of motor block (p\u2009=\u20090.185) at the Th4 level. Fewer pregnant women required additional local anesthetics in the ropivacaine group compared to the chloroprocaine group (4.5% VS. 34.8%, p\u2009=\u20090.011). The ropivacaine group had lower intraoperative VAS scores (p\u2009=\u20090.023) and higher patient satisfaction scores (p\u2009=\u20090.040) than the chloroprocaine group. The incidence of intraoperative complications was similar between the two groups, and no serious complications were observed.\nOur study found that 0.75% ropivacaine was associated with less intraoperative pain treatment, higher patient satisfaction and reduced the onset time compared to 3% chloroprocaine in pregnant women undergoing urgent cesarean delivery during labor analgesia period. Therefore, 0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period.\nThe registration number: ChiCTR2200065201; http://www.chictr.org.cn , Principal investigator: MEN, Date of registration: 31/10/2022.",
    "authors": [
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Xin",
            "initials": "X",
            "lastname": "Men"
        },
        {
            "affiliation": "Department of Anesthesiology, Zhejiang Hospital, The Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China.",
            "firstname": "Qian",
            "initials": "Q",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Jia-Fu",
            "initials": "JF",
            "lastname": "Dong"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Pei",
            "initials": "P",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Xiao-Xiao",
            "initials": "XX",
            "lastname": "Qiu"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Yin-Qiu",
            "initials": "YQ",
            "lastname": "Han"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Wei-Long",
            "initials": "WL",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Jin",
            "initials": "J",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China.",
            "firstname": "Hong-Yan",
            "initials": "HY",
            "lastname": "Shou"
        },
        {
            "affiliation": "Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, 310008, China. zhenfeng9853@163.com.",
            "firstname": "Zhen-Feng",
            "initials": "ZF",
            "lastname": "Zhou"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s12871-024-02597-4\n10.1097/ALN.0000000000002322\n10.1186/s12871-023-02373-w\n10.1080/01443615.2020.1755621\n10.1111/j.1365-2044.1982.tb01315.x\n10.1213/ANE.0000000000005141\n10.1097/00000542-198001000-00010\n10.1016/0002-9378(85)90295-9\n10.1097/00000542-199303000-00013\n10.1097/00000542-198909000-00046\n10.1111/j.1365-2044.2004.03753.x\n10.1097/00000542-199002000-00019\n10.1093/bja/76.2.300\n10.1097/00000542-199507000-00004\n10.1177/014107680009300703\n10.1111/j.1399-6576.1965.tb00523.x\n10.1111/j.1365-2044.2006.04609.x\n10.1111/anae.12927\n10.1016/j.ijoa.2005.06.010\n10.1111/j.1399-6576.2006.00937.x\n10.1097/00000542-199004000-00022\n10.1097/00115550-200711000-00002\n10.1016/S0149-7634(99)00020-2\n10.1016/0165-6147(96)10003-1\n10.1111/anae.12034\n10.1016/0959-289X(95)82995-M\n10.1054/ijoa.2000.0770\n10.1093/bja/aer300\n10.1093/bja/60.2.180\n10.1016/0959-289X(91)90024-K\n10.1097/00000542-198903000-00013\n10.1093/oxfordjournals.bja.a013476\n10.1016/S0959-289X(03)00009-8\n10.1177/0310057X0102900508\n10.1186/s44158-022-00083-2\n10.3390/jcm11154498\n10.3390/jcm12237295\n10.1111/j.1365-2044.2007.05342.x",
    "journal": "BMC anesthesiology",
    "keywords": [
        "Chloroprocaine",
        "Epidural",
        "Ropivacaine",
        "Urgent cesarean delivery"
    ],
    "methods": null,
    "publication_date": "2024-06-26",
    "pubmed_id": "38918712\n29939847\n38097947\n32496840\n24659334\n7103022\n32852294\n7352645\n3970100\n8457050\n1832945\n2528307\n15488058\n2301764\n8777115\n7605013\n10928020\n5322004\n16674620\n25388969\n16256334\n16480471\n2157353\n18035290\n10541058\n8936343\n23061397\n15636981\n15321620\n21997149\n3345279\n15636790\n2538094\n10823102\n15321451\n11669430\n37386677\n35956113\n38068347\n18289229",
    "results": "There was a significant difference between the two groups in the time to achieve loss of cold sensation (303, 95%CI 255 to 402\u00a0S vs. 372, 95%CI 297 to 630\u00a0S, p\u2009=\u20090.024). There was no significant difference the degree of motor block (p\u2009=\u20090.185) at the Th4 level. Fewer pregnant women required additional local anesthetics in the ropivacaine group compared to the chloroprocaine group (4.5% VS. 34.8%, p\u2009=\u20090.011). The ropivacaine group had lower intraoperative VAS scores (p\u2009=\u20090.023) and higher patient satisfaction scores (p\u2009=\u20090.040) than the chloroprocaine group. The incidence of intraoperative complications was similar between the two groups, and no serious complications were observed.",
    "title": "0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period.",
    "xml": "<Element 'PubmedArticle' at 0x788504553790>"
}