{
    "abstract": "The overuse of antibiotics result drug resistance in bacterial pathogens, imposing significant healthcare challenges and socioeconomic costs. Developing artificial nanozymes is one of the promising candidates for the substitution of antibiotics for the purpose of antibacterial of drug-resistant bacteria, but it still remains a huge challenge. Herein, we report a new class of layered dual-metal nodes metal-organic frameworks (MOF) (SrCa-MOF) for promoting the photosynthesis of reactive oxygen species (ROS), significantly enhancing the antibacterial activity relative to traditional single-metal nodes MOFs nanozymes. Density functional theory (DFT) simulations demonstrate that the introduction of Ca metal decreases the d-band center of SrCa-MOF (-2.15\u00a0eV), which can promote the production of ROS for enhancing the antibacterial. The as-made SrCa-MOF shows excellent antibacterial activity of 78.16\u00a0% and 79.83\u00a0% for Methicillin-Resistant Staphylococcus aureus (MRS. aureus) and Escherichia coli (E. coli), which are 2-fold higher than that of Sr-MOF (single Sr nodes metal-organic frameworks). In vivo experiments display that SrCa-MOF possesses efficient wound healing rate of 95.05\u00a0% within 8\u00a0days, significantly higher than Sr-MOF (70.21\u00a0%). Overall, our work provides a new strategy for enhancing the antibacterial performance of MOF nanozymes and opens new avenues for the development of highly efficient artificial nanozymes.",
    "authors": [
        {
            "affiliation": "Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.",
            "firstname": "Qinqin",
            "initials": "Q",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, PR China.",
            "firstname": "Fangyong",
            "initials": "F",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, PR China.",
            "firstname": "Shihan",
            "initials": "S",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Materials Science and Engineering, Peking University, Beijing 100871, PR China.",
            "firstname": "Yachao",
            "initials": "Y",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, PR China. Electronic address: kqguoyaru@bjmu.edu.cn.",
            "firstname": "Yaru",
            "initials": "Y",
            "lastname": "Guo"
        },
        {
            "affiliation": "Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: liuyxpost@pku.edu.cn.",
            "firstname": "Youxing",
            "initials": "Y",
            "lastname": "Liu"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.jcis.2025.137608",
    "journal": "Journal of colloid and interface science",
    "keywords": [
        "Antibacterial",
        "Artificial nanozymes",
        "Bimetallic nodes",
        "Metal-organic frameworks",
        "Reactive oxygen species"
    ],
    "methods": null,
    "publication_date": "2025-04-22",
    "pubmed_id": "40262206",
    "results": null,
    "title": "Layered dual-metal nodes metal organic frameworks artificial nanozymes boost the production of reactive oxygen species for antibacterial of drug-resistant bacteria.",
    "xml": "<Element 'PubmedArticle' at 0x788502dab560>"
}