{
    "abstract": "To assess if the use of a V-Y reconstructive flap after excisional radical surgery positively influences the surgical outcomes in patients with vulvar cancer.\nThis was a multicenter, retrospective, controlled study. Surgical outcomes and complication rates of women with invasive vulvar cancer who underwent radical surgery and vulvar reconstruction and those who underwent radical surgery without the reconstruction step were compared. Only patients who underwent bilateral or unilateral V-Y advancement fascio-cutaneous flaps were included in the reconstruction group. Univariate and multivariate logistic regression models were used to analyze predicting variables for their association with complication rates.\nOverall, 361 patients were included: 190 (52%) underwent the reconstructive step after the excisional radical procedure and were compared with 171 (47.4%) who did not undergo the reconstructive step. At multivariate analysis, body mass index >30\u2009kg/m\nThe adoption of V-Y flaps in vulvar surgery was correlated with reduced surgical related complications, particularly in vulnerable patients involving large surgical defects following excisional radical procedures.",
    "authors": [
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy violante.didonato@uniroma1.it.",
            "firstname": "Violante",
            "initials": "V",
            "lastname": "Di Donato"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Andrea",
            "initials": "A",
            "lastname": "Giannini"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Valerio",
            "initials": "V",
            "lastname": "Galli"
        },
        {
            "affiliation": "Unit of Gynecologic Oncology, National Cancer Institute - IRCCS - Fondazione \"G. Pascale\", Naples, Italy.",
            "firstname": "Mariano Catello",
            "initials": "MC",
            "lastname": "Di Donna"
        },
        {
            "affiliation": "Chirurgien gyn\u00e9co-oncologique Clinique Champeau M\u00e9diterran\u00e9e et Clinique Causse B\u00e9ziers et Colombiers, Beziers, France.",
            "firstname": "Mario Antonio",
            "initials": "MA",
            "lastname": "Congiu"
        },
        {
            "affiliation": "Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.\nDipartimento Scienze della Vita e Sanit\u00e0 Pubblica, Sezione Ginecologia e Ostetricia, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.",
            "firstname": "Giorgia",
            "initials": "G",
            "lastname": "Garganese"
        },
        {
            "affiliation": "Research Unit of Gynaecology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico Di Roma, Rome, Italy.\nDivision of ob/gyn, Ospedale Isola Tiberina Gemelli Isola, Rome, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "Plotti"
        },
        {
            "affiliation": "Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Florence, Italy.",
            "firstname": "Flavia",
            "initials": "F",
            "lastname": "Sorbi"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Tullio",
            "initials": "T",
            "lastname": "Golia D'Aug\u00e8"
        },
        {
            "affiliation": "Unit of Obstetrics and Gynecology, \"Paolo Giaccone\" Hospital, Palermo, Italy.\nDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.",
            "firstname": "Antonio Simone",
            "initials": "AS",
            "lastname": "Lagan\u00e0"
        },
        {
            "affiliation": "Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.\nDepartment of Plastic Surgery, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Rome, Italy.",
            "firstname": "Stefano",
            "initials": "S",
            "lastname": "Gentileschi"
        },
        {
            "affiliation": "Department of Plastic Surgery, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Rome, Italy.",
            "firstname": "Anna Amelia",
            "initials": "AA",
            "lastname": "Caretto"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Ilaria",
            "initials": "I",
            "lastname": "Cuccu"
        },
        {
            "affiliation": "Malzoni Research Hospital, Avellino, Italy.",
            "firstname": "Francesca",
            "initials": "F",
            "lastname": "Falcone"
        },
        {
            "affiliation": "Malzoni Research Hospital, Avellino, Italy.",
            "firstname": "Mario",
            "initials": "M",
            "lastname": "Malzoni"
        },
        {
            "affiliation": "Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Ospedale Sandro Pertini, Rome, Italy.",
            "firstname": "Enzo",
            "initials": "E",
            "lastname": "Ricciardi"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Giorgia",
            "initials": "G",
            "lastname": "Perniola"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Camilla",
            "initials": "C",
            "lastname": "Turetta"
        },
        {
            "affiliation": "Department of Gynecology with Center for Oncological Surgery, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany.",
            "firstname": "Helmut",
            "initials": "H",
            "lastname": "Plett"
        },
        {
            "affiliation": "Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Florence, Italy.",
            "firstname": "Massimiliano",
            "initials": "M",
            "lastname": "Fambrini"
        },
        {
            "affiliation": "Unit of Gynecologic Oncology, National Cancer Institute - IRCCS - Fondazione \"G. Pascale\", Naples, Italy.\nDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.",
            "firstname": "Vito",
            "initials": "V",
            "lastname": "Chiantera"
        },
        {
            "affiliation": "Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCSS-Regina Elena National Cancer Institute, Rome, Italy.",
            "firstname": "Enrico",
            "initials": "E",
            "lastname": "Vizza"
        },
        {
            "affiliation": "Research Unit of Gynaecology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico Di Roma, Rome, Italy.",
            "firstname": "Roberto",
            "initials": "R",
            "lastname": "Angioli"
        },
        {
            "affiliation": "Gynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "Raspagliesi"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Ludovico",
            "initials": "L",
            "lastname": "Muzii"
        },
        {
            "affiliation": "Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.\nDipartimento Scienze della Vita e Sanit\u00e0 Pubblica, Sezione Ginecologia e Ostetricia, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.",
            "firstname": "Giovanni",
            "initials": "G",
            "lastname": "Scambia"
        },
        {
            "affiliation": "Department of Gynecological, Obstetrical and Urological Sciences, \"Sapienza\" University of Rome, Rome, Italy.",
            "firstname": "Pierluigi",
            "initials": "P",
            "lastname": "Benedetti Panici"
        },
        {
            "affiliation": "Gynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.",
            "firstname": "Giorgio",
            "initials": "G",
            "lastname": "Bogani"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.",
    "doi": "10.1136/ijgc-2024-005486",
    "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
    "keywords": [
        "Gynecologic Surgical Procedures",
        "Postoperative complications",
        "Quality of Life (PRO)/Palliative Care",
        "Surgical Flaps",
        "Vulvar and Vaginal Cancer"
    ],
    "methods": null,
    "publication_date": "2024-07-14",
    "pubmed_id": "39002981",
    "results": "Overall, 361 patients were included: 190 (52%) underwent the reconstructive step after the excisional radical procedure and were compared with 171 (47.4%) who did not undergo the reconstructive step. At multivariate analysis, body mass index >30\u2009kg/m",
    "title": "Role of V-Y flap reconstruction in vulvar cancer patients: multicenter retrospective study.",
    "xml": "<Element 'PubmedArticle' at 0x78850477f830>"
}