{
    "abstract": "This review article explores the challenges and controversies involved in accurately identifying and reliably quantifying coronary plaque over time through coronary computed tomography angiography (CCTA), particularly focusing on lipid-rich, low-attenuation plaques. It highlights significant variability in lipid-rich plaque measurements across studies, questioning their reliability for tracking biological plaque transformation in clinical practice. To address this issue, the review article proposes suggestions for serial CCTA plaque measurements, aiming for realistic goals for reproducible and meaningful serial plaque CCTA imaging. It also emphasizes the necessity of standardized, validated methods for quantitative plaque analysis and underscores the potential of phantom-based calibration to improve the reliability and consistency of serial plaque measurements in clinical practice.",
    "authors": [
        {
            "affiliation": "Department of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.",
            "firstname": "Francesca",
            "initials": "F",
            "lastname": "Calicchio"
        },
        {
            "affiliation": "Department of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.",
            "firstname": "Elizabeth",
            "initials": "E",
            "lastname": "Epstein"
        },
        {
            "affiliation": "Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.",
            "firstname": "Melinda",
            "initials": "M",
            "lastname": "Boussoussou"
        },
        {
            "affiliation": "Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.",
            "firstname": "Borb\u00e1la",
            "initials": "B",
            "lastname": "Vattay"
        },
        {
            "affiliation": "Department of Cardiology, Leiden University Medical Center, 2333 ZA, Leiden, the Netherlands.",
            "firstname": "Alexander",
            "initials": "A",
            "lastname": "van Rosendael"
        },
        {
            "affiliation": "Department of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.",
            "firstname": "Shawn",
            "initials": "S",
            "lastname": "Newlander"
        },
        {
            "affiliation": "Department of Cardiology, Gottsegen National Cardiovascular Center, Haller u. 29, 1096 Budapest, Hungary.\nPhysiological Controls Research Center, B\u00e9csi \u00fat 96b, \u00d3buda University, 1034 Budapest, Hungary.",
            "firstname": "M\u00e1rton",
            "initials": "M",
            "lastname": "Kolossv\u00e1ry"
        },
        {
            "affiliation": "Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.",
            "firstname": "B\u00e1lint",
            "initials": "B",
            "lastname": "Szilveszter"
        },
        {
            "affiliation": "Medical Imaging Center, Semmelweis University, \u00dcll\u0151i \u00fat 78a, 1082 Budapest, Hungary.",
            "firstname": "P\u00e1l",
            "initials": "P",
            "lastname": "Maurovich-Horvat"
        },
        {
            "affiliation": "UNICA Radiology, Hospital da Luz Lisboa, Av. Lus\u00edada 100, Cat\u00f3lica Medical School, 1500-650 Lisboa, Portugal.",
            "firstname": "Hugo",
            "initials": "H",
            "lastname": "Marques"
        },
        {
            "affiliation": "Department of Medicine, UC San Diego School of Medicine, 9500 Gilman Dr, 92093 La Jolla, CA, USA.\nDepartment of Cardiovascular Division, UC San Diego School of Medicine, 9500 Gilman Dr, 92093 La Jolla, CA, USA.\nDepartment of Radiology, UC San Diego School of Medicine, 9500 Gilman Dr, 92093 La Jolla, CA, USA.\nDepartment of Bioengineering, UC San Diego School of Medicine, 9500 Gilman Dr, 92093 La Jolla, CA, USA.",
            "firstname": "Elliot",
            "initials": "E",
            "lastname": "McVeigh"
        },
        {
            "affiliation": "Department of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.",
            "firstname": "George",
            "initials": "G",
            "lastname": "Wesbey"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.",
    "doi": "10.1093/ehjimp/qyaf014\n10.1117/12.2651307",
    "journal": "European heart journal. Imaging methods and practice",
    "keywords": [
        "coronary CT angiography",
        "energy integrating detector CT (EID-CT)",
        "low-attenuation plaque (LAP)",
        "photon-counting detector CT (PCD-CT)",
        "quantitative coronary plaque analysis"
    ],
    "methods": null,
    "publication_date": "2025-03-11",
    "pubmed_id": "40066146\n33303383\n38849237\n37255042\n36266205\n37689744\n24257284\n17456875\n37523236\n32876901\n31603567\n39925379\n37495488\n38306457\n38836185\n30571779\n25153157\n31468205\n32154773\n34326003\n24370164\n27636027\n35025834\n38588491\n38836185\n28372786\n16494883\n23614976\n32927971\n28126251\n37410009\n37600044\n17322636\n17659199\n29857958\n38514283\n2868172\n37944269\n37488295\n26754621\n36869934\n36728452\n34419398\n29944083\n26429276\n38618158\n37480907\n36158821\n32174130\n20820922\n15750815\n31078917\n20083056\n23417447\n38205656\n32518032\n38320905\n31028446\n30782511\n28214139\n39045182\n24040139\n36603478\n29233836\n28346329\n33591887\n35648210\n30447949\n33423941\n35337643",
    "results": null,
    "title": "Impact of technical, patient-related and measurement variables on serial Hounsfield unit-based quantitative coronary plaque analysis in computed tomography: time for a new chapter.",
    "xml": "<Element 'PubmedArticle' at 0x7885027f2610>"
}