{
    "abstract": "Anemia is a common problem in preterm neonates, and red blood cell transfusion (RBCT) is used to improve oxygen delivery. However, RBCT is associated with complications, although an increase in cerebral oxygenation has been documented, and no universally accepted biomarker for the need for transfusion (i.e., the concentration of hemoglobin in the blood) has been defined.\nWe used a hybrid optical device (BabyLux device) that merges time-domain near-infrared spectroscopy (TD-NIRS) and diffuse correlation spectroscopy (DCS) to potentially obtain a better assessment of the cerebral effects of RBCT compared with previous studies using continuous wave (CW) spatially resolved NIRS.\nEighteen clinically stable preterm neonates were assessed before and after RBCT by the BabyLux device as five repetitions of 60\u00a0s measurement (with 1\u00a0s acquisition time), estimating the cerebral blood flow (CBF) as a blood flow index (BFI), the total hemoglobin concentration (tHb), and the cerebral tissue oxygen saturation ( \nThe BabyLux data from four neonates did not meet quality criteria and were discarded. After the transfusion, tHb and \nThe results confirm previous CW-NIRS studies, but the wide variability of BFI makes the effects of RBCT on cerebral metabolism uncertain.",
    "authors": [
        {
            "affiliation": "Politecnico di Milano, Dipartimento di Fisica, Milan, Italy.",
            "firstname": "Caterina",
            "initials": "C",
            "lastname": "Amendola"
        },
        {
            "affiliation": "NICU Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy.",
            "firstname": "Agnese",
            "initials": "A",
            "lastname": "De Carli"
        },
        {
            "affiliation": "NICU Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy.",
            "firstname": "Tiziana",
            "initials": "T",
            "lastname": "Boggini"
        },
        {
            "affiliation": "Politecnico di Milano, Dipartimento di Fisica, Milan, Italy.",
            "firstname": "Davide",
            "initials": "D",
            "lastname": "Contini"
        },
        {
            "affiliation": "NICU Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy.",
            "firstname": "Sofia",
            "initials": "S",
            "lastname": "Passera"
        },
        {
            "affiliation": "University of Milano-Bicocca, Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, Milan, Italy.",
            "firstname": "Nicola",
            "initials": "N",
            "lastname": "Pesenti"
        },
        {
            "affiliation": "Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Milan, Italy.",
            "firstname": "Lorenzo",
            "initials": "L",
            "lastname": "Spinelli"
        },
        {
            "affiliation": "ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Casteldefells, Spain.",
            "firstname": "Martina",
            "initials": "M",
            "lastname": "Giovannella"
        },
        {
            "affiliation": "ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Casteldefells, Spain.\nICREA - Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, Barcelona, Spain.",
            "firstname": "Turgut",
            "initials": "T",
            "lastname": "Durduran"
        },
        {
            "affiliation": "HemoPhotonics SL, Casteldefells, Spain.",
            "firstname": "Udo M",
            "initials": "UM",
            "lastname": "Weigel"
        },
        {
            "affiliation": "Politecnico di Milano, Dipartimento di Fisica, Milan, Italy.\nIstituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Milan, Italy.",
            "firstname": "Alessandro",
            "initials": "A",
            "lastname": "Torricelli"
        },
        {
            "affiliation": "Rigshospitalet and University of Copenhagen, Department of Neonatology, Copenhagen, Denmark.",
            "firstname": "Gorm",
            "initials": "G",
            "lastname": "Greisen"
        },
        {
            "affiliation": "NICU Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy.\nUniversity of Milan, Department of Clinical Sciences and Community Health, Milan, Italy.",
            "firstname": "Monica",
            "initials": "M",
            "lastname": "Fumagalli"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Authors.",
    "doi": "10.1117/1.NPh.11.4.045014\n10.1159/000486584\n10.1055/s-0036-1584300\n10.1111/j.1537-2995.2008.01881.x\n10.1056/nejm199902113400601\n10.1007/s00134-007-0741-9\n10.1016/j.athoracsur.2008.09.079\n10.1213/ane.0b013e31819029b2\n10.1056/NEJMoa2020248\n10.1001/jama.2020.10690\n10.1371/journal.pone.0256810\n10.1055/s-0030-1247598\n10.1203/00006450-199903000-00009\n10.1136/adc.2009.163592\n10.1111/vox.12436\n10.1038/jp.2013.188\n10.1136/adc.2010.191023\n10.1111/j.1442-200X.2008.02733.x\n10.1007/BF01712170\n10.1007/s001340000712\n10.1203/00006450-199009000-00006\n10.1136/adc.65.7_Spec_No.672\n10.1038/jp.2013.39\n10.1111/j.1469-8749.1988.tb14558.x\n10.1111/j.1651-2227.2002.tb02881.x\n10.3389/fped.2021.644462\n10.1001/jamanetworkopen.2023.34889\n10.1016/j.neuroimage.2013.05.106\n10.1088/0034-4885/73/7/076701\n10.1038/s41390-019-0474-9\n10.1117/1.NPh.6.2.025007\n10.1364/AO.40.000185\n10.1002/mrm.1910300405\n10.1103/PhysRevLett.75.1855\n10.1364/JOSAA.14.000192\n10.1177/0271678X19883751\n10.1136/archdischild-2018-316400\n10.1364/BOE.417357\n10.1136/archdischild-2018-316400\n10.1117/1.NPh.10.4.045003\n10.1117/1.nph.3.3.031412\n10.1364/BOE.397613",
    "journal": "Neurophotonics",
    "keywords": [
        "NIRS",
        "cerebral hemodynamics",
        "cerebral metabolic rate of oxygen extraction",
        "diffuse correlation spectroscopy",
        "preterm neonates",
        "time domain NIRS"
    ],
    "methods": null,
    "publication_date": "2024-12-18",
    "pubmed_id": "39691580\n29550819\n27249797\n18673342\n9971864\n17572875\n19101294\n19224781\n33382931\n32780138\n34460843\n20099219\n10088652\n20466739\n27509230\n2681578\n21097838\n19419500\n8796405\n11280639\n2235114\n2386399\n23619372\n3042495\n12412869\n33718309\n37733345\n23747285\n26120204\n31234195\n31093515\n18356990\n8255190\n10060408\n31665953\n31085677\n33996206\n31085677\n37841558\n27335889\n32923078",
    "results": "The BabyLux data from four neonates did not meet quality criteria and were discarded. After the transfusion, tHb and ",
    "title": "Effects of red blood cell transfusion on cerebral hemodynamics of preterm neonates.",
    "xml": "<Element 'PubmedArticle' at 0x788503637380>"
}