{
    "abstract": "Evaluations of pulmonary, cough, and swallow function are frequently performed to assess disease progression in amyotrophic lateral sclerosis (ALS), yet the relationship between these functions remains unknown. We therefore aimed to determine relationships between these measures in individuals with ALS.\nOne hundred individuals with ALS underwent standardized tests: forced vital capacity (FVC), maximum expiratory/inspiratory pressure (MEP, MIP), voluntary cough peak expiratory flow (PEF), and videofluoroscopic swallow evaluation (VF). Duplicate raters completed independent, blinded ratings using the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) scale. Descriptives, Spearman's Rho correlations, Kruskal-Wallis analyses, and Pearson's chi-squared tests were completed.\nMean and standard deviation across pulmonary and cough measures were FVC: 74.2% predicted (\u00b1\u200922.6), MEP: 91.6\u2009cmH\nIn this cohort of individuals with ALS, pulmonary function, and voluntary cough were associated. Expiratory metrics (MEP, PEF) were diminished in individuals with unsafe swallowing, increasing their risk for effectively defending the airway.",
    "authors": [
        {
            "affiliation": "Aerodigestive Research Core Laboratory, The Ohio State University, Columbus, Ohio, USA.\nDepartment of Hearing and Speech Sciences, Vanderbilt University, Nashville, Tennessee, USA.",
            "firstname": "Cara",
            "initials": "C",
            "lastname": "Donohue"
        },
        {
            "affiliation": "Department of Anesthesiology, University of Florida, Gainesville, Florida, USA.",
            "firstname": "Terrie",
            "initials": "T",
            "lastname": "Vasilopoulos"
        },
        {
            "affiliation": "Department of Neurology, University of Florida, Gainesville, Florida, USA.",
            "firstname": "James P",
            "initials": "JP",
            "lastname": "Wymer"
        },
        {
            "affiliation": "Aerodigestive Research Core Laboratory, The Ohio State University, Columbus, Ohio, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.",
            "firstname": "Emily K",
            "initials": "EK",
            "lastname": "Plowman"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Authors. Muscle & Nerve published by Wiley Periodicals LLC.",
    "doi": "10.1002/mus.28113\n10.1001/jamaneurol.2017.3339\n10.1080/21678421.2021.1910713\n10.1111/ane.12136\n10.1007/s00455-021-10315-2\n10.1016/j.otohns.2004.09.092\n10.1177/0145561320951647\n10.1044/2020_AJSLP-19-00136\n10.1002/mus.26408\n10.3389/fneur.2018.00578\n10.23736/S0031-0808.21.04104-5\n10.1002/mus.24990\n10.1002/acn3.623\n10.1002/acn3.342\n10.1002/mus.26292\n10.1007/s00455-015-9686-2\n10.1007/s00455-021-10346-9\n10.1080/21678421.2017.1353097\n10.1002/mus.26320\n10.1212/wnl.53.5.1059\n10.3109/17482960802566824\n10.1080/21678421.2018.1452945\n10.3109/21678421.2015.1049183\n10.1164/rccm.166.4.518\n10.1044/persp2.SIG13.147\n10.1002/cncr.34079\n10.1016/j.jbi.2008.08.010\n10.1016/j.jbi.2019.103208\n10.1371/journal.pone.0236804\n10.1213/ANE.0000000000002864\n10.1016/s0022-510x(01)00617-7\n10.1080/21678421.2016.1249486\n10.1590/s0004-282\u00d72013000300004\n10.1007/s00455-015-9687-1",
    "journal": "Muscle & nerve",
    "keywords": [
        "amyotrophic lateral sclerosis",
        "cough",
        "dysphagia",
        "pulmonary function",
        "swallowing"
    ],
    "methods": null,
    "publication_date": "2024-05-15",
    "pubmed_id": "38742544\n29181534\n34348540\n23668293\n34037850\n15746870\n33044841\n32650651\n30620104\n30050497\n33687180\n26599236\n30250869\n27752517\n29981250\n26837611\n34297153\n28728441\n30106482\n10496266\n19922118\n29566571\n26121170\n12186831\n26283871\n34985765\n18929686\n31078660\n32790801\n29481436\n11676995\n27915482\n23563713\n26803772",
    "results": "Mean and standard deviation across pulmonary and cough measures were FVC: 74.2% predicted (\u00b1\u200922.6), MEP: 91.6\u2009cmH",
    "title": "Relationship between pulmonary, cough, and swallowing functions in individuals with amyotrophic lateral sclerosis.",
    "xml": "<Element 'PubmedArticle' at 0x788501fabfb0>"
}