{
    "abstract": "Bleeding assessment tools (BATs) have been developed to quantify bleeding severity. Their ability to predict for the diagnosis of a bleeding disorder has not been thoroughly investigated.\nTo evaluate the ability of the Vicenza BAT and the ISTH BAT to distinguish patients with an established bleeding disorder from those with bleeding of unknown cause (BUC).\nThree-hundred fifty-nine patients (228 with BUC, 64%) from the Vienna Bleeding Biobank were assessed in this study.\nThe bleeding scores were similar in patients with an established diagnosis of a bleeding disorder compared to patients with BUC. Both BATs had a low sensitivity and specificity for the diagnosis of a bleeding disorder with areas under the receiver operating characteristic (ROC) curves of 0.53 (95% confidence interval 0.47-0.60) for the Vicenza BAT and 0.52 (0.46-0.59) for the ISTH BAT. In terms of specific diagnoses, both scores were most accurate in diagnosing von Willebrand disease (VWD, areas under the ROC curve; Vicenza BAT 0.67 (0.45-0.90); ISTH BAT 0.70 (0.50-0.90)). A separate evaluation of different bleeding symptoms in patients who had undergone surgery and tooth extraction revealed that postpartum bleeding and bleeding from small wounds was predictive for diagnosing a MBD in multivariable analysis.\nThe Vicenza- and the ISTH BAT have a low ability to distinguish patients with an established bleeding disorder from those with BUC.",
    "authors": [
        {
            "affiliation": "Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Electronic address: johanna.gebhart@meduniwien.ac.at.",
            "firstname": "Johanna",
            "initials": "J",
            "lastname": "Gebhart"
        },
        {
            "affiliation": "Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.",
            "firstname": "Stefanie",
            "initials": "S",
            "lastname": "Hofer"
        },
        {
            "affiliation": "Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria.",
            "firstname": "Alexandra",
            "initials": "A",
            "lastname": "Kaider"
        },
        {
            "affiliation": "Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.",
            "firstname": "Judit",
            "initials": "J",
            "lastname": "Rejt\u00f6"
        },
        {
            "affiliation": "Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.",
            "firstname": "Cihan",
            "initials": "C",
            "lastname": "Ay"
        },
        {
            "affiliation": "Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.",
            "firstname": "Ingrid",
            "initials": "I",
            "lastname": "Pabinger"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.ejim.2020.04.023",
    "journal": "European journal of internal medicine",
    "keywords": [
        "Bleeding assessment tool",
        "Bleeding of unknown cause",
        "ISTH-BAT",
        "Mild bleeding tendency",
        "Platelet function defect",
        "Von Willebrand disease"
    ],
    "methods": null,
    "publication_date": "2020-04-23",
    "pubmed_id": "32317240",
    "results": "The bleeding scores were similar in patients with an established diagnosis of a bleeding disorder compared to patients with BUC. Both BATs had a low sensitivity and specificity for the diagnosis of a bleeding disorder with areas under the receiver operating characteristic (ROC) curves of 0.53 (95% confidence interval 0.47-0.60) for the Vicenza BAT and 0.52 (0.46-0.59) for the ISTH BAT. In terms of specific diagnoses, both scores were most accurate in diagnosing von Willebrand disease (VWD, areas under the ROC curve; Vicenza BAT 0.67 (0.45-0.90); ISTH BAT 0.70 (0.50-0.90)). A separate evaluation of different bleeding symptoms in patients who had undergone surgery and tooth extraction revealed that postpartum bleeding and bleeding from small wounds was predictive for diagnosing a MBD in multivariable analysis.",
    "title": "The discriminatory power of bleeding assessment tools in adult patients with a mild to moderate bleeding tendency.",
    "xml": "<Element 'PubmedArticle' at 0x788505093510>"
}