{
    "abstract": "Medical nutrition therapy provides the opportunity to compensate for muscle wasting and immune response activation during stress and trauma. The objective of this systematic review is to assess the safety and effectiveness of early enteral nutrition (EEN) in adults with sepsis or septic shock.\nThe MEDLINE, Embase, CENTRAL, CINAHL, ClinicalTrials.gov, and ICTRP tools were searched from inception until July 2023. Conference proceedings, the reference lists of included studies, and expert content were queried to identify additional publications. Two review authors completed the study selection, data extraction, and risk of bias assessment; disagreements were resolved through discussion. Inclusion criteria were randomized controlled trials (RCTs) and non-randomized studies (NRSs) comparing the administration of EEN with no or delayed enteral nutrition (DEE) in adult populations with sepsis or septic shock.\nFive RCTs (\nLow-quality evidence suggests that EEN may be a safe and effective intervention for the management of critically ill patients with sepsis or septic shock.",
    "authors": [
        {
            "affiliation": "Department of Internal Medicine, School of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia.\nDepartment of Obstetrics & Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia.\nIntensive Care Unit, Hospital Universitario San Ignacio, Bogot\u00e1 110231, Colombia.",
            "firstname": "Carlos F",
            "initials": "CF",
            "lastname": "Grillo-Ardila"
        },
        {
            "affiliation": "Department of Internal Medicine, School of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia.\nIntensive Care Unit, Hospital Universitario San Ignacio, Bogot\u00e1 110231, Colombia.",
            "firstname": "Diego",
            "initials": "D",
            "lastname": "Tibavizco-Palacios"
        },
        {
            "affiliation": "Department of Internal Medicine, School of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia.\nIntensive Care Unit, Hospital Universitario San Ignacio, Bogot\u00e1 110231, Colombia.",
            "firstname": "Luis C",
            "initials": "LC",
            "lastname": "Triana"
        },
        {
            "affiliation": "Department of Surgery, School of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia.",
            "firstname": "Sa\u00fal J",
            "initials": "SJ",
            "lastname": "Rugeles"
        },
        {
            "affiliation": "Clinical Research Institute, Universidad Nacional de Colombia, Bogot\u00e1 11001, Colombia.",
            "firstname": "Mar\u00eda T",
            "initials": "MT",
            "lastname": "Vallejo-Ortega"
        },
        {
            "affiliation": "Department of Internal Medicine, School of Medicine, Universidad del Bosque, Bogot\u00e1 11001, Colombia.",
            "firstname": "Carlos H",
            "initials": "CH",
            "lastname": "Calder\u00f3n-Franco"
        },
        {
            "affiliation": "School of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia.",
            "firstname": "Juan J",
            "initials": "JJ",
            "lastname": "Ram\u00edrez-Mosquera"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/nu16111560\n10.1001/jama.2016.0287\n10.1007/s00134-021-06506-y\n10.18597/RCOG.3413\n10.1002/jpen.2267\n10.4103/0972-5229.123438\n10.1186/s13054-017-1906-8\n10.1016/j.clnu.2016.09.010\n10.1371/journal.pone.0058838\n10.3390/nu14051120\n10.1097/CCM.0000000000003445\n10.1097/MD.0000000000011871\n10.1016/j.clnu.2023.07.011\n10.1186/cc13720\n10.4037/ajcc2010197\n10.1002/9780470712184\n10.1002/jrsm.1078\n10.1002/ijgo.13681\n10.1371/journal.pmed.1000097\n10.1136/bmj.i4919\n10.1186/1471-2288-14-135\n10.1016/j.jclinepi.2017.05.006\n10.1016/j.jclinepi.2016.03.018\n10.1097/01.CCM.0000297954.45251.A9\n10.1007/s00268-005-7491-z\n10.1002/jpen.1706\n10.3748/wjg.v25.i22.2799\n10.1177/000313481808400656\n10.21037/apm-20-1650\n10.1016/j.jcrc.2018.06.026\n10.1177/0885066618809893\n10.35366/110441\n10.1186/s13054-022-04047-4\n10.1177/0885066614554887\n10.1097/MD.0000000000007702\n10.3349/ymj.2022.0276\n10.18597/rcog.2482\n10.18597/rcog.227\n10.18597/rcog.517\n10.18597/rcog.79\n10.3390/nu15143201",
    "journal": "Nutrients",
    "keywords": [
        "critical care",
        "enteral nutrition",
        "sepsis",
        "systematic review"
    ],
    "methods": null,
    "publication_date": "2024-06-19",
    "pubmed_id": "38892494\n26903338\n34599691\n32770871\n34784064\n24501485\n29297385\n27686693\n23527035\n35268095\n30222632\n30142782\n37517372\n24506888\n8867397\n20436064\n26053539\n33754367\n19621072\n27733354\n25524443\n28529184\n27063205\n18007263\n15981045\n15235203\n31535394\n31236002\n29981639\n33302649\n29990793\n30384813\n0\n35681220\n25315218\n28796054\n36996897\n37513620",
    "results": "Five RCTs (",
    "title": "Early Enteral Nutrition (within 48 h) for Patients with Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788502a67470>"
}