{
    "abstract": "COPD and interstitial lung disease (ILD) are significant chronic respiratory disorders, impacting quality of life. Respiratory muscle roles and differences remain not entirely clear. The objective of the present study was to evaluate the degree of recruitment of the respiratory muscles and the work of breathing in COPD and ILD during exercise.\nWe compared the sensory-mechanical relationships in COPD, ILD and healthy controls (n=20 each). They performed pulmonary function, noninvasive and invasive respiratory muscle strength, surface electromyography and work-of-breathing assessments.\nCOPD and ILD did not show lower static muscle strength compared to controls, but did show poor performance in the exercise test with increased transdiaphragmatic pressure (\nEarly and increased activity of the respiratory muscles and work-of-breathing components significantly contribute to dyspnoea, exercise intolerance and neuromechanical inefficiency of ventilation in COPD and ILD. The mechanisms of ",
    "authors": [
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.\nIntensive Care Unit, AC Camargo Cancer Center, S\u00e3o Paulo, Brazil.",
            "firstname": "Jeferson George",
            "initials": "JG",
            "lastname": "Ferreira"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.",
            "firstname": "Vin\u00edcius Carlos",
            "initials": "VC",
            "lastname": "Iamonti"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.",
            "firstname": "Mayra",
            "initials": "M",
            "lastname": "Caleffi Pereira"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.",
            "firstname": "Renata",
            "initials": "R",
            "lastname": "Pletsch-Assun\u00e7\u00e3o"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.",
            "firstname": "Marcelo Ceneviva",
            "initials": "MC",
            "lastname": "Macchione"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.\nIntensive Care Unit, AC Camargo Cancer Center, S\u00e3o Paulo, Brazil.",
            "firstname": "Pauliane Vieira",
            "initials": "PV",
            "lastname": "Santana"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.\nIntensive Care Unit, AC Camargo Cancer Center, S\u00e3o Paulo, Brazil.",
            "firstname": "Let\u00edcia Zumpano",
            "initials": "LZ",
            "lastname": "Cardenas"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.\nIntensive Care Unit, AC Camargo Cancer Center, S\u00e3o Paulo, Brazil.",
            "firstname": "Pedro",
            "initials": "P",
            "lastname": "Caruso"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.",
            "firstname": "Carlos R R",
            "initials": "CRR",
            "lastname": "de Carvalho"
        },
        {
            "affiliation": "Pulmonary Division, Heart Institute (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil.\nS\u00edrio-Liban\u00eas Teaching and Research Institute, S\u00e3o Paulo, Brazil.",
            "firstname": "Andr\u00e9 L P",
            "initials": "ALP",
            "lastname": "de Albuquerque"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9The authors 2024.",
    "doi": "10.1183/23120541.00059-2023\n10.1152/japplphysiol.01470.2005\n10.3389/fphys.2017.00082\n10.1152/jappl.1983.54.5.1216\n10.1164/ajrccm.155.1.9001298\n10.1097/SPC.0000000000000377\n10.1164/ajrccm.164.5.2012122\n10.1152/japplphysiol.00981.2012\n10.1159/000077416\n10.1152/jappl.1998.84.6.2000\n10.1164/rccm.201504-0841OC\n10.1183/09031936.05.00034905\n10.1183/09031936.05.00034805\n10.1183/09031936.05.00035005\n10.1590/S0100-879X1999000600006\n10.1590/S0100-879X1999000600008\n10.1590/s1806-37132007000400008\n10.1378/chest.93.3.580\n10.1136/thorax.56.11.880\n10.1590/S1806-37132015000004474\n10.1590/S1806-37132012000600004\n10.1590/S0100-879X1999000600007\n10.1164/arrd.1982.126.5.788\n10.1186/s12890-018-0698-1\n10.1164/rccm.166.4.518\n10.1007/s00134-006-0278-3\n10.1152/jappl.1985.59.6.1842\n10.1164/rccm.200707-1064OC\n10.1136/thx.35.2.92\n10.1152/jappl.1994.77.2.963\n10.1152/japplphysiol.01010.2002\n10.1136/thx.2006.072884\n10.1016/j.resp.2019.04.011\n10.1111/resp.14064\n10.1183/09059180.00010002\n10.1152/japplphysiol.00008.2009\n10.1164/arrd.1984.129.1.33\n10.1136/thx.2010.151332\n10.1136/thoraxjnl-2015-207188\n10.1183/09031936.98.11020416\n10.1152/japplphysiol.01078.2017\n10.1080/09593985.2019.1656314\n10.1164/rccm.200407-887OC\n10.1183/09031936.00072008\n10.1056/NEJM199109263251304",
    "journal": "ERJ open research",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-07-09",
    "pubmed_id": "38978542\n16675610\n28275353\n6223015\n9001298\n30074922\n11549531\n23519228\n15133338\n9609795\n26407036\n16204605\n16055882\n16135736\n10412549\n10412551\n17982531\n3342669\n11641515\n25972965\n23288114\n10412550\n15636646\n7149443\n30068327\n12186831\n7154893\n16838150\n4077793\n18006885\n7376125\n8002554\n12807898\n17557772\n31029769\n33860975\n19359620\n6230971\n21597112\n26194996\n9551747\n29543134\n31429627\n15735057\n19196822\n1881417",
    "results": "COPD and ILD did not show lower static muscle strength compared to controls, but did show poor performance in the exercise test with increased transdiaphragmatic pressure (",
    "title": "Differences of ventilatory muscle recruitment and work of breathing in COPD and interstitial lung disease during exercise: a comprehensive evaluation.",
    "xml": "<Element 'PubmedArticle' at 0x788506aeb3d0>"
}