{
    "abstract": "Vanished twin (VT) has been associated with poor perinatal outcomes. Our research aimed to investigate the outcomes of pregnancies with vanished twin and its possible association with methylenetetrahydrofolate reductase (MTHFR) polymorphisms.\nThis study consisted of 30 of 38 VT pregnancies (group 1, VT group), 109 singletons (group 2), 70 spontaneous twins (group 3), and 101 in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) twins (group 4).\nMost patients in group 1 (28/30) were tested for MTHFR genes (C677T or A1298C polymorphisms). Eight of the 38 pregnancies with VT (21.1%) resulted in miscarriage. The prevalence of \"2 or more pregnancy losses\" in the \"obstetric history\" in group 1 was higher (23.3%) than those in the other groups (p\u2009=\u20090.007, \u03c7\nThe coincidence of VT and MTHFR polymorphisms might play an incidental or factual role in this connection.",
    "authors": [
        {
            "affiliation": "Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey. aykut.spm@gmail.com.\nGazi University School of Medicine, 06500, Besevler-Ankara, Turkey. aykut.spm@gmail.com.",
            "firstname": "Murat Aykut",
            "initials": "MA",
            "lastname": "Ozek"
        },
        {
            "affiliation": "Department of Biostatistics, Hacettepe University Medical Faculty, Ankara, Turkey.",
            "firstname": "Ergun",
            "initials": "E",
            "lastname": "Karaagaoglu"
        },
        {
            "affiliation": "Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.",
            "firstname": "Gokcen",
            "initials": "G",
            "lastname": "Orgul"
        },
        {
            "affiliation": "Division of Hematology Department of Pediatrics, Hacettepe University Medical Faculty, Ankara, Turkey.",
            "firstname": "Fatma",
            "initials": "F",
            "lastname": "Gumruk"
        },
        {
            "affiliation": "Division of Neonatology, Department of Pediatrics, Hacettepe University Medical Faculty, Ankara, Turkey.",
            "firstname": "Murat",
            "initials": "M",
            "lastname": "Yurdak\u00f6k"
        },
        {
            "affiliation": "Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.",
            "firstname": "M Sinan",
            "initials": "MS",
            "lastname": "Beksac"
        }
    ],
    "conclusions": "The coincidence of VT and MTHFR polymorphisms might play an incidental or factual role in this connection.",
    "copyrights": null,
    "doi": "10.1007/s10815-018-1346-7\n10.1093/humupd/4.2.177\n10.1067/mob.2002.118915\n10.1093/humrep/dei142\n10.1093/humupd/dmp009\n10.1097/GCO.0b013e3283404e44\n10.1016/S0301-2115(01)00496-1\n10.1093/eurheartj/ehi815\n10.1089/gtmb.2011.0318\n10.1016/j.fertnstert.2012.12.027\n10.1016/j.amjmed.2004.01.019\n10.1007/s11010-013-1869-2\n10.1111/j.1600-0897.2011.00996.x\n10.1016/j.neulet.2008.10.074\n10.1590/S0036-36342009000100006\n10.1007/s00439-016-1652-z\n10.1038/ng0595-111\n10.1055/a-0664-8237\n10.1016/j.rbmo.2009.11.015\n10.1002/cbf.1132\n10.1159/000081280\n10.3109/14767058.2014.916268\n10.1093/humrep/dem225\n10.1016/j.metabol.2004.06.003\n10.1086/303055\n10.1093/jn/126.suppl_4.1285S\n10.3945/jn.109.113670\n10.1111/j.0001-6349.2005.00882.x\n10.1007/s10815-017-1015-2\n10.1093/hmg/ddm187\n10.1186/1868-7083-3-7\n10.1073/pnas.081540898\n10.1016/j.devcel.2015.12.027\n10.1016/S0143-4004(05)80193-6\n10.1375/twin.14.1.88\n10.1375/twin.4.4.227",
    "journal": "Journal of assisted reproduction and genetics",
    "keywords": [
        "Methylenetetrahydrofolate reductase polymorphism",
        "Miscarriage",
        "Multiple pregnancies",
        "Vanished twin"
    ],
    "methods": null,
    "publication_date": "2018-10-27",
    "pubmed_id": "30362058\n3047607\n9683354\n11810089\n15979998\n19270317\n20930630\n11803092\n16524890\n22313097\n23357458\n15210385\n24213682\n21410812\n18983896\n19180309\n27068821\n7647779\n24247802\n30258247\n20113963\n15386535\n15564739\n24749801\n17728356\n15536605\n10930360\n11588136\n7647779\n27775595\n8642472\n19812215\n16232180\n28842818\n17636251\n22414254\n11274372\n26812015\n2290799\n21314260\n11665301",
    "results": "Most patients in group 1 (28/30) were tested for MTHFR genes (C677T or A1298C polymorphisms). Eight of the 38 pregnancies with VT (21.1%) resulted in miscarriage. The prevalence of \"2 or more pregnancy losses\" in the \"obstetric history\" in group 1 was higher (23.3%) than those in the other groups (p\u2009=\u20090.007, \u03c7",
    "title": "Comparison of different types of twin pregnancies in terms of obstetric and perinatal outcomes: association of vanished twins with methylenetetrahydrofolate reductase (MTHFR) polymorphism(s).",
    "xml": "<Element 'PubmedArticle' at 0x7885064113a0>"
}