{
    "abstract": "Patients with polycystic ovary syndrome (PCOS) have a higher risk of obstetric complications. The association between anti-M\u00fcllerian hormone (AMH) and gestational hypertension in these patients is poorly understood.\nTo determine the association between serum AMH levels and gestational hypertension in patients with PCOS undergoing fresh embryo transfer.\nThis retrospective study included 649 patients with PCOS who had singleton live births after undergoing fresh embryo transfers. The association of AMH with gestational hypertension in these patients was estimated before and after propensity score matching.\nPatients with gestational hypertension had higher AMH levels than those without gestational hypertension. In single-factor logistic regression, the odds of gestational hypertension increased by 11.7% and 18.6% for every 1ng/mL increase in AMH before and after adjusting for confounding factors (odds ratio [OR], 1.117; 95% CI, 1.025-1.217; P = .012; adjusted OR, 1.186; 95% CI, 1.061-1.327; adjusted P = .003), respectively. The odds of gestational hypertension increased more than 100% (adjusted OR, 2.635; 95% CI, 1.132-6.137; adjusted P = .025) in the 75th percentile group (>9.30\u2005ng/mL) and more than 3 times (adjusted OR, 4.75; 95% CI, 1.672-13.495; adjusted P = .003) in the 90th percentile group (>12.31\u2005ng/mL) compared to the without gestational hypertension group. AMH level was still associated with gestational hypertension after propensity score matching. The area under the curve of AMH predicting gestational hypertension was 0.654 (95% CI, 0.532-0.776; P = .011) with an optimal cutoff value of 11.975\u2005ng/mL.\nHigh serum AMH level prepregnancy (especially at levels >9.30\u2005ng/mL) indicates a high odds of gestational hypertension in patients with PCOS undergoing fresh embryo transfer.",
    "authors": [
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Menghui",
            "initials": "M",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Shujun",
            "initials": "S",
            "lastname": "Liu"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Fuli",
            "initials": "F",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Hao",
            "initials": "H",
            "lastname": "Shi"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Fang",
            "initials": "F",
            "lastname": "Wang"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Caihong",
            "initials": "C",
            "lastname": "Chen"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Qingling",
            "initials": "Q",
            "lastname": "Yang"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Shanjun",
            "initials": "S",
            "lastname": "Dai"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Yuling",
            "initials": "Y",
            "lastname": "Liang"
        },
        {
            "affiliation": "Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.\nHenan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.",
            "firstname": "Yihong",
            "initials": "Y",
            "lastname": "Guo"
        }
    ],
    "conclusions": "High serum AMH level prepregnancy (especially at levels >9.30\u2005ng/mL) indicates a high odds of gestational hypertension in patients with PCOS undergoing fresh embryo transfer.",
    "copyrights": "\u00a9 The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.",
    "doi": "10.1210/clinem/dgae324\n10.6084/m9.figshare.24533923.v2\n10.6084/m9.figshare.25376716.v1\n10.6084/m9.figshare.24533815.v2\n10.6084/m9.figshare.24526681.v2\n10.6084/m9.figshare.24533824.v2",
    "journal": "The Journal of clinical endocrinology and metabolism",
    "keywords": [
        "in vitro fertilization",
        "anti-M\u00fcllerian hormone",
        "gestational hypertension",
        "polycystic ovary syndrome"
    ],
    "methods": null,
    "publication_date": "2024-05-13",
    "pubmed_id": "38739541\n29569621\n19591989\n26117684\n31725884\n28865551\n31973904\n21777422\n30146442\n23844593\n29760445\n32443077\n30316413\n25267788\n33995280\n24588691\n27842995\n31586179\n21752527\n24953352\n31859547\n35115166\n27509101\n36150546\n24058309\n33378532\n34603211\n31752768\n31036431\n24418062\n25924655\n26074093\n32883514\n28977597\n10854429\n24613539\n16982667\n23223073",
    "results": "Patients with gestational hypertension had higher AMH levels than those without gestational hypertension. In single-factor logistic regression, the odds of gestational hypertension increased by 11.7% and 18.6% for every 1ng/mL increase in AMH before and after adjusting for confounding factors (odds ratio [OR], 1.117; 95% CI, 1.025-1.217; P = .012; adjusted OR, 1.186; 95% CI, 1.061-1.327; adjusted P = .003), respectively. The odds of gestational hypertension increased more than 100% (adjusted OR, 2.635; 95% CI, 1.132-6.137; adjusted P = .025) in the 75th percentile group (>9.30\u2005ng/mL) and more than 3 times (adjusted OR, 4.75; 95% CI, 1.672-13.495; adjusted P = .003) in the 90th percentile group (>12.31\u2005ng/mL) compared to the without gestational hypertension group. AMH level was still associated with gestational hypertension after propensity score matching. The area under the curve of AMH predicting gestational hypertension was 0.654 (95% CI, 0.532-0.776; P = .011) with an optimal cutoff value of 11.975\u2005ng/mL.",
    "title": "High AMH Levels Are Associated With Gestational Hypertension in Patients With PCOS who Underwent IVF/ICSI-ET.",
    "xml": "<Element 'PubmedArticle' at 0x78850414c360>"
}