{
    "abstract": "The volume kinetics of a commercially available colloid fluid, Gelofusine, have not been studied previously.\nIntravenous Gelofusine 10 mL/kg was infused over 30 min in 15 patients undergoing vascular surgery. Of the 15 patients, 14 were classified as American Society of Anesthesiologists (ASA) class III status. The distribution and elimination of the infused volume was calculated with mixed-model kinetics based on 280 measurements of the hemoglobin-derived plasma dilution (19 per patient) collected over 180 min.\nThe expanded central fluid space volume (V\nThe kinetics of Gelofusine was predictable in patients of American Society of Anesthesiologists class III status undergoing vascular surgery, with the fluid expanding the vascular space and the half-life shortened by noradrenaline.\nRetrospectively registered with ClinicalTrials.gov NCT06474052, June 24, 2024.",
    "authors": [
        {
            "affiliation": "1st, Department of Cardiovascular Anesthesia and Intensive Care Medicine, Dr. C.C. Iliescu Institute for Emergency Cardiovascular Diseases, Bucharest, Romania.",
            "firstname": "Cosmin",
            "initials": "C",
            "lastname": "Balan"
        },
        {
            "affiliation": "1st, Department of Cardiovascular Anesthesia and Intensive Care Medicine, Dr. C.C. Iliescu Institute for Emergency Cardiovascular Diseases, Bucharest, Romania.",
            "firstname": "Cristian",
            "initials": "C",
            "lastname": "Boros"
        },
        {
            "affiliation": "1st, Department of Cardiovascular Anesthesia and Intensive Care Medicine, Dr. C.C. Iliescu Institute for Emergency Cardiovascular Diseases, Bucharest, Romania.",
            "firstname": "Serban-Ion",
            "initials": "SI",
            "lastname": "Bubenek-Turconi"
        },
        {
            "affiliation": "Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, 182 88, Stockholm, Sweden. robert.hahn@ki.se.",
            "firstname": "Robert G",
            "initials": "RG",
            "lastname": "Hahn"
        }
    ],
    "conclusions": "The kinetics of Gelofusine was predictable in patients of American Society of Anesthesiologists class III status undergoing vascular surgery, with the fluid expanding the vascular space and the half-life shortened by noradrenaline.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1007/s40262-025-01500-9\n10.1016/s0750-7658(94)80038-3\n10.1007/s00134-012-2472-9\n10.1093/bja/aes098\n10.1111/aas.13533\n10.1007/s00394-020-02275-4\n10.1371/journal.pone.0290071\n10.1016/j.ekir.2022.01.1057\n10.1002/9781118784860\n10.1186/cc12749\n10.1213/ANE.0000000000005802\n10.1111/aas.14074\n10.1097/00000658-196310000-00016\n10.1111/j.1399-6576-2010.02244.x\n10.1097/ALN.0000000000005002\n10.1159/000158759\n10.1097/TXD.0000000000000876\n10.1186/s40635-020-00317-z\n10.1097/TA.0000000000003013\n10.1111/aas.13150\n10.1186/s12871-024-02494-w\n10.1042/CS20040303\n10.1097/CCM.0b013e3181bc80f1\n10.1007/s00134-006-0454-5\n10.1213/ANE.0000000000004323\n10.1097/EJA.0b013e3283592733\n10.1186/s12871-021-01351-4\n10.1177/0310057X1204000104\n10.1177/0310057X1103900324\n10.1016/j.jcrc.2016.04.011\n10.1007/s00134-012-2560-x\n10.1097/CCM.0b013e3182978fb6\n10.1128/AAC.00985-17\n10.1186/s40635-022-00458-3\n10.1111/1440-1681.13439\n10.1213/ANE.0000000000002075\n10.1152/physrev.1971.51.3.527\n10.1097/00000542-200206000-00016\n10.1007/s12630-017-1045-3",
    "journal": "Clinical pharmacokinetics",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-03-23",
    "pubmed_id": "40121598\n22323076\n22508964\n31863457\n37590224\n21936146\n35497800\n23718743\n34797221\n35491239\n14067514\n20455879\n38739769\n2758107\n30993191\n32651934\n33491937\n29845612\n38539087\n19789444\n17119921\n31306244\n23047301\n33957864\n22313061\n21675073\n27481739\n22527076\n23978813\n28923868\n35849214\n28452823\n4950077\n12170049",
    "results": "The expanded central fluid space volume (V",
    "title": "Volume Kinetics of Gelofusine 4% During Vascular Surgery.",
    "xml": "<Element 'PubmedArticle' at 0x788503287e70>"
}