{
    "abstract": "Typhoid fever, leading to systemic disease due to Salmonella enterica serotype Typhi, typically has gastrointestinal manifestation, however, neurologic complications-although uncommon, can arise. Aseptic meningitis and optic neuritis are rare manifestations that can be challenging to diagnose.\nOur patient a 31-year male presented with fever for 18 days associated with headache, rash, vomiting, diarrhea and progressive neurological symptoms in form of disorientation and blurred vision. On examination there was bilateral sixth cranial nerve palsy. Investigations were positive for typhoid fever with aseptic meningitis and optic neuritis. He was successfully treated with intravenous ceftriaxone and corticosteroids.\nAtypical neurological symptoms of typhoid fever must be recognized. To prevent complications, early diagnosis and treatment are important. Typhoid fever should be considered in febrile patients with unexplainable neurological symptoms, especially in an endemic region.",
    "authors": [
        {
            "affiliation": "Department of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.",
            "firstname": "Nikhat Shahla",
            "initials": "NS",
            "lastname": "Afsar"
        },
        {
            "affiliation": "Department of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.",
            "firstname": "Sumaiya Farah",
            "initials": "SF",
            "lastname": "Marisa"
        },
        {
            "affiliation": "Department of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.",
            "firstname": "Sayat Quayum",
            "initials": "SQ",
            "lastname": "Mohona"
        },
        {
            "affiliation": "Department of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.",
            "firstname": "Sohely",
            "initials": "S",
            "lastname": "Ashraf"
        },
        {
            "affiliation": "Department of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.",
            "firstname": "Mahfuzur",
            "initials": "M",
            "lastname": "Rahman"
        },
        {
            "affiliation": "Department of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.",
            "firstname": "Chowdhury Adnan",
            "initials": "CA",
            "lastname": "Sami"
        }
    ],
    "conclusions": "Atypical neurological symptoms of typhoid fever must be recognized. To prevent complications, early diagnosis and treatment are important. Typhoid fever should be considered in febrile patients with unexplainable neurological symptoms, especially in an endemic region.",
    "copyrights": "\u00a9 2025 The Authors. Published by Elsevier Ltd.",
    "doi": "10.1016/j.idcr.2025.e02203\n10.1038/s41572-023-00480-z",
    "journal": "IDCases",
    "keywords": [
        "Aseptic meningitis",
        "Neuro involvement",
        "Optic neuritis",
        "Typhoid"
    ],
    "methods": null,
    "publication_date": "2025-04-14",
    "pubmed_id": "40226208\n38097589\n15837356\n16183516\n23324301\n23226492\n23814211\n34194179\n15597296\n38976339\n37089797",
    "results": null,
    "title": "A case of typhoid fever with neurological presentation.",
    "xml": "<Element 'PubmedArticle' at 0x788502152480>"
}