{
    "abstract": "Patulin (PAT) is a harmful polyketide mycotoxin that contaminates fruits and vegetables, posing significant food safety risks and severe health hazards to humans. This study revealed that the growth and morphology of Meyerozyma guilliermondii were affected by PAT stress. Exposure to PAT led to accelerated oxidative stress and apoptosis of M. guilliermondii. However, despite these adverse effects, M. guilliermondii retained the ability to completely degrade PAT within 72\u00a0h. Under PAT stress, the activities of antioxidant-related and glutathione metabolism-related enzymes in M. guilliermondii significantly increased, thereby mitigating reactive oxygen species (ROS) accumulation and maintaining cellular viability to support PAT degradation. Furthermore, a key enzyme in M. guilliermondii, short-chain dehydrogenase/reductase (MgSDR), was found to degrade PAT into ascladiol. The results demonstrated that M. guilliermondii activated a self-protection mechanism while simultaneously degrading PAT, which provided a theoretical basis for developing biological control agents that combine mycotoxin detoxification with stress tolerance. The study promotes the future application of biological resources in juice detoxification.",
    "authors": [
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.",
            "firstname": "Qianhua",
            "initials": "Q",
            "lastname": "Zhao"
        },
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.",
            "firstname": "Esa Abiso",
            "initials": "EA",
            "lastname": "Godana"
        },
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.",
            "firstname": "Yuchun",
            "initials": "Y",
            "lastname": "Lu"
        },
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.",
            "firstname": "Xi",
            "initials": "X",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.",
            "firstname": "Qiya",
            "initials": "Q",
            "lastname": "Yang"
        },
        {
            "affiliation": "Department of Agricultural, Environmental and Food Sciences, Universit\u00e0 degli Studi del Molise, Francesco de Sanctis, 86100, Campobasso, Italy.",
            "firstname": "Raffaello",
            "initials": "R",
            "lastname": "Castoria"
        },
        {
            "affiliation": "School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China. Electronic address: zhanghongyin126@126.com.",
            "firstname": "Hongyin",
            "initials": "H",
            "lastname": "Zhang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.ijbiomac.2025.143290",
    "journal": "International journal of biological macromolecules",
    "keywords": [
        "Detoxification",
        "Mycotoxin",
        "Self-protection mechanism",
        "Short-chain dehydrogenase/reductase"
    ],
    "methods": null,
    "publication_date": "2025-04-20",
    "pubmed_id": "40253034",
    "results": null,
    "title": "Mechanism of patulin detoxification by Meyerozyma guilliermondii: Integrating physiological analysis with a short-chain dehydrogenase/reductase study.",
    "xml": "<Element 'PubmedArticle' at 0x788506397bf0>"
}