{
    "abstract": "This study aimed to assess the effects of focal brain cooling (FBC) on human brain tissue through use of multiple sensing techniques by monitoring cerebrovascular activity and brain temperature.\nIntraoperative brain activity monitoring using a multimodality probe capable of measuring brain temperature, electrocorticography (ECoG) and changes in cerebral hemoglobin concentration was performed in 13 patients with refractory epilepsy. Brain temperature and neurovascular activity were measured beneath and surrounding the FBC device. Data were categorized into three temperature ranges [low-temperature range (LTR, <18\u00a0\u00b0C), moderate-temperature range (MTR, 18\u00a0\u00b0C-28\u00a0\u00b0C), and high-temperature range (HTR, >28\u00a0\u00b0C)] for analysis.\nChanges in oxyhemoglobin (\u0394O\nFBC selectively influenced brain electrical activity and hemoglobin concentration, highlighting its subtle effects on neurovascular dynamics.\nThese findings provide critical insights into optimizing cooling strategies for neurological disorders using multimodality probes and FBC devices.",
    "authors": [
        {
            "affiliation": "Organization of Research Initiatives, Yamaguchi University, Ube, Japan. Electronic address: takao@inoue.name.",
            "firstname": "Takao",
            "initials": "T",
            "lastname": "Inoue"
        },
        {
            "affiliation": "Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.",
            "firstname": "Sadahiro",
            "initials": "S",
            "lastname": "Nomura"
        },
        {
            "affiliation": "Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.",
            "firstname": "Toshitaka",
            "initials": "T",
            "lastname": "Yamakawa"
        },
        {
            "affiliation": "Organization of Research Initiatives, Yamaguchi University, Ube, Japan.",
            "firstname": "Sayuki",
            "initials": "S",
            "lastname": "Takara"
        },
        {
            "affiliation": "Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.",
            "firstname": "Hirochika",
            "initials": "H",
            "lastname": "Imoto"
        },
        {
            "affiliation": "Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.",
            "firstname": "Yuichi",
            "initials": "Y",
            "lastname": "Maruta"
        },
        {
            "affiliation": "Graduate School of Medical Photonics, Shizuoka University, Hamamatsu, Japan.",
            "firstname": "Masatsugu",
            "initials": "M",
            "lastname": "Niwayama"
        },
        {
            "affiliation": "Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.",
            "firstname": "Michiyasu",
            "initials": "M",
            "lastname": "Suzuki"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 The Author(s). Published by Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.clinph.2025.02.262",
    "journal": "Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology",
    "keywords": [
        "Cerebral hemodynamics",
        "Clinical study",
        "Cortical temperature",
        "Electrocorticogram",
        "Focal brain cooling",
        "Intraoperative monitoring",
        "Near-infrared spectroscopy"
    ],
    "methods": null,
    "publication_date": "2025-03-13",
    "pubmed_id": "40073587",
    "results": "Changes in oxyhemoglobin (\u0394O",
    "title": "Intraoperative evaluation using a multimodality probe of temperature-dependent neurovascular modulation during focal brain cooling.",
    "xml": "<Element 'PubmedArticle' at 0x788504c214e0>"
}