{
    "abstract": "The cytokines secreted by immune cells have a large impact on the tissue, surrounding a fracture, e.g., by attraction of osteoprogenitor cells. However, the underlying mechanisms are not yet fully understood. Thus, this study aims at investigating molecular mechanisms of the immune cell-mediated migration of immature primary human osteoblasts (phOBs), with transforming growth factor beta (TGF-\u03b2), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (",
    "authors": [
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. sabrina.ehnert@med.uni-tuebingen.de.",
            "firstname": "Sabrina",
            "initials": "S",
            "lastname": "Ehnert"
        },
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. caren.linnemann@student.uni-tuebingen.de.",
            "firstname": "Caren",
            "initials": "C",
            "lastname": "Linnemann"
        },
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. rominaaspera@hotmail.com.",
            "firstname": "Romina H",
            "initials": "RH",
            "lastname": "Aspera-Werz"
        },
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. daria.bykova@student.uni-tuebingen.de.",
            "firstname": "Daria",
            "initials": "D",
            "lastname": "Bykova"
        },
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. sarabiermann@web.de.",
            "firstname": "Sara",
            "initials": "S",
            "lastname": "Biermann"
        },
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. leonie.fecht@web.de.",
            "firstname": "Leonie",
            "initials": "L",
            "lastname": "Fecht"
        },
        {
            "affiliation": "Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. pdezwart@bgu-tuebingen.de.",
            "firstname": "Peter M",
            "initials": "PM",
            "lastname": "De Zwart"
        },
        {
            "affiliation": "Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. andreas.nuessler@gmail.com.",
            "firstname": "Andreas K",
            "initials": "AK",
            "lastname": "Nussler"
        },
        {
            "affiliation": "Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. fstuby@bgu-tuebingen.de.",
            "firstname": "Fabian",
            "initials": "F",
            "lastname": "Stuby"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ijms19082239\n10.1001/jamasurg.2016.2775\n10.1016/j.injury.2014.04.002\n10.1007/s00441-011-1205-7\n10.1517/14712598.2014.857653\n10.1186/s40634-017-0079-3\n10.1146/annurev.immunol.24.021605.090737\n10.1186/2045-3701-3-4\n10.1016/j.bone.2005.02.011\n10.1002/jcb.240550312\n10.1091/mbc.9.7.1903\n10.1083/jcb.105.1.457\n10.1038/ncb434\n10.1007/s00109-017-1526-4\n10.1186/1741-7015-10-101\n10.1002/jbmr.5650050805\n10.1161/CIRCRESAHA.109.193722\n10.1161/CIRCRESAHA.109.202986\n10.1254/jphs.10R01CR\n10.1091/mbc.e09-12-1003\n10.1089/ars.2008.2203\n10.1152/ajplung.00269.2005\n10.1042/BJ20061846\n10.1152/ajpheart.00918.2013\n10.1038/bjc.2014.165\n10.18632/oncotarget.17892\n10.1371/journal.pone.0008668\n10.1073/pnas.75.5.2458\n10.1016/j.freeradbiomed.2012.06.016\n10.1016/j.actbio.2017.01.056\n10.1016/j.jot.2017.04.002\n10.1302/0301-620X.72B5.2211764\n10.1002/jor.20901\n10.22203/eCM.v032a10\n10.1182/blood-2009-06-221630\n10.1038/nrrheum.2012.1\n10.1371/journal.pone.0014073\n10.1089/ars.2013.5814\n10.1161/HYPERTENSIONAHA.107.100214\n10.1016/j.mce.2016.07.011\n10.3390/healthcare4030060\n10.1172/JCI67603\n10.1038/s41598-017-14983-9\n10.1016/j.freeradbiomed.2011.09.030",
    "journal": "International journal of molecular sciences",
    "keywords": [
        "NADPH oxidase 4 (NOX4)",
        "focal adhesion kinase (FAK)",
        "migration",
        "primary human osteoblasts (phOBs)"
    ],
    "methods": null,
    "publication_date": "2018-08-02",
    "pubmed_id": "30065198\n27603155\n24857025\n21789579\n24397854\n28176273\n16551245\n23321200\n15811636\n7962167\n9658179\n3475276\n17762890\n28271209\n22958403\n2239366\n19574552\n19644055\n20838023\n20427574\n18783311\n16227320\n17407446\n25063792\n24714748\n28574838\n20084270\n276884\n22728268\n28119112\n29094003\n2211764\n19382195\n27452963\n19696199\n22293759\n21124921\n24383718\n18086956\n27396899\n27571113\n24216508\n29109418\n22027063",
    "results": null,
    "title": "Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-\u03b2 Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase.",
    "xml": "<Element 'PubmedArticle' at 0x7885041fe2a0>"
}