{
    "abstract": "Doxorubicin (DOX) is a widely used cytotoxic drug whose application is limited by its severe side effects. Little was known regarding how to offset its side effects. Therefore this study aims to explore the role of miR-200a-3p in DOX-induced cardiotoxicity and its possible mechanism. DOX-induced myocardial injury rat models were established, which were then injected with miR-200a-3p inhibitor (miR-200a-3p suppression) to observe the effects of miR-200a-3p on cell proliferation, and apoptosis. Heart function and weights of rat models were also measured. Cardiomyocytes were induced by DOX, in which PEG3 knockdown or corresponding plasmids were transfected to assess the possible effect of PEG3 on cell activity. Dual luciferase reporter assay was applied to verify the binding of PEG3 with miR-200a-3p. Elevated levels of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and left ventricular end-diastolic pressure (LVEDP), as well as suppressed left ventricular systolic pressure (LVSP) and\u2009\u00b1\u2009dp/dt ",
    "authors": [
        {
            "affiliation": "Department of Cardiovasology, Hunan Provincial People's Hospital, Changsha, Hunan, 410000, People's Republic of China. 56071317@qq.com.",
            "firstname": "Qinghua",
            "initials": "Q",
            "lastname": "Fu"
        },
        {
            "affiliation": "Department of Cardiovasology, Hunan Provincial People's Hospital, Changsha, Hunan, 410000, People's Republic of China.",
            "firstname": "Hongwei",
            "initials": "H",
            "lastname": "Pan"
        },
        {
            "affiliation": "Department of Cardiovasology, Hunan Provincial People's Hospital, Changsha, Hunan, 410000, People's Republic of China.",
            "firstname": "Yi",
            "initials": "Y",
            "lastname": "Tang"
        },
        {
            "affiliation": "Department of Cardiovasology, Hunan Provincial People's Hospital, Changsha, Hunan, 410000, People's Republic of China.",
            "firstname": "Jingjing",
            "initials": "J",
            "lastname": "Rong"
        },
        {
            "affiliation": "Department of Cardiovasology, Hunan Provincial People's Hospital, Changsha, Hunan, 410000, People's Republic of China.",
            "firstname": "Zhaofen",
            "initials": "Z",
            "lastname": "Zheng"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1007/s12012-020-09620-3\n10.18632/oncotarget.2410\n10.1039/C9FO00063A\n10.1177/1559325818813061\n10.4103/2141-9248.126619\n10.5603/CJ.a2017.0018\n10.1002/jcp.26283\n10.1089/ars.2017.7328\n10.1080/15384101.2015.1026491\n10.3892/ijmm.2016.2719\n10.1038/s41598-018-32941-x\n10.1371/journal.pone.0178363\n10.1016/j.jacc.2017.06.010\n10.1007/s10863-020-09831-x\n10.1016/j.ijcard.2015.12.008\n10.1159/000373937\n10.1016/j.ijbiomac.2017.01.074\n10.1002/jcp.24969\n10.1093/abbs/gmy093\n10.1016/j.cca.2014.10.036\n10.1016/j.freeradbiomed.2013.07.007\n10.2353/ajpath.2007.061042\n10.2147/OTT.S195234\n10.1093/cvr/cvv238\n10.1016/j.bbrc.2016.01.095\n10.1159/000490020\n10.1111/acel.12940\n10.1016/j.redox.2018.07.002\n10.1016/j.biopha.2018.12.122\n10.1371/journal.pone.0056325\n10.1074/jbc.M116.769950\n10.1038/s41598-017-10016-7\n10.1371/journal.pone.0170391\n10.1016/j.toxlet.2019.02.007\n10.1016/j.redox.2017.11.023\n10.1016/j.toxlet.2017.04.018\n10.1016/j.ijcard.2015.04.245\n10.1038/srep07456\n10.3892/ijmm.2016.2618",
    "journal": "Cardiovascular toxicology",
    "keywords": [
        "Apoptosis",
        "Doxorubicin-induced myocardial injury",
        "NF-\u03baB",
        "PEG3",
        "Proliferation",
        "SIRT1",
        "miR-200a-3p"
    ],
    "methods": null,
    "publication_date": "2021-02-28",
    "pubmed_id": "33638775\n24361676\n31781322",
    "results": null,
    "title": "MiR-200a-3p Aggravates DOX-Induced Cardiotoxicity by Targeting PEG3 Through SIRT1/NF-\u03baB Signal Pathway.",
    "xml": "<Element 'PubmedArticle' at 0x7885047613f0>"
}