{
    "abstract": "The efficacy of different uterotonic agents is yet to be determined.\nThis was a randomized clinical trial on 240 pregnant mothers with a history of cesarean section in three groups: A: sublingual misoprostol and oxytocin, B: intrauterine misoprostol and oxytocin, and C: a higher dose of oxytocin alone. The intrapartum blood loss and the estimated blood loss within 24\u202fh after surgery were compared between the groups.\nThe baseline characteristics showed no significant differences among the groups. The volume of blood loss during surgery and within 24\u202fh postpartum did not differ significantly among the groups (A: 230.72\u202f\u00b1\u202f97.30, B: 245.60\u202f\u00b1\u202f88.50, C: 229.02\u202f\u00b1\u202f109.78, p\u202f=\u202f0.115, and A: 2023.84\u202f\u00b1\u202f480.08, B: 2045.26\u202f\u00b1\u202f598.99, C: 2025.61\u202f\u00b1\u202f538.93, p\u202f=\u202f0.819, respectively).\nIntrauterine misoprostol plus oxytocin, sublingual misoprostol plus oxytocin and a higher dose of oxytocin did not show any significant difference in the amount of blood loss during surgery and within 24\u202fh post-operation.",
    "authors": [
        {
            "affiliation": "Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.",
            "firstname": "Mahdieh",
            "initials": "M",
            "lastname": "Masoumzadeh"
        },
        {
            "affiliation": "Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.",
            "firstname": "Vahideh",
            "initials": "V",
            "lastname": "Rahmani"
        },
        {
            "affiliation": "Fellowship of Gynecologic Oncology. Women's Reproductive Health Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.",
            "firstname": "Manizheh",
            "initials": "M",
            "lastname": "Sayyah-Melli"
        },
        {
            "affiliation": "Tabriz University of Medical Sciences, Tabriz, Iran.",
            "firstname": "Anis",
            "initials": "A",
            "lastname": "Sani"
        }
    ],
    "conclusions": "Intrauterine misoprostol plus oxytocin, sublingual misoprostol plus oxytocin and a higher dose of oxytocin did not show any significant difference in the amount of blood loss during surgery and within 24\u202fh post-operation.",
    "copyrights": "\u00a9 2025 The Authors.",
    "doi": "10.1016/j.eurox.2025.100369",
    "journal": "European journal of obstetrics & gynecology and reproductive biology: X",
    "keywords": [
        "Cesarean Section",
        "Misoprostol",
        "Oxytocin",
        "Postpartum hemorrhage"
    ],
    "methods": null,
    "publication_date": "2025-02-25",
    "pubmed_id": "39995616\n16581405\n23586122\n0\n30503400\n29775434\n23689739\n27536161\n31010345\n35734671\n30176758\n19902675\n30569545\n33323832\n21060308\n33064852",
    "results": "The baseline characteristics showed no significant differences among the groups. The volume of blood loss during surgery and within 24\u202fh postpartum did not differ significantly among the groups (A: 230.72\u202f\u00b1\u202f97.30, B: 245.60\u202f\u00b1\u202f88.50, C: 229.02\u202f\u00b1\u202f109.78, p\u202f=\u202f0.115, and A: 2023.84\u202f\u00b1\u202f480.08, B: 2045.26\u202f\u00b1\u202f598.99, C: 2025.61\u202f\u00b1\u202f538.93, p\u202f=\u202f0.819, respectively).",
    "title": "The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial.",
    "xml": "<Element 'PubmedArticle' at 0x788504f4e4d0>"
}