{
    "abstract": "Progress has been made toward developing therapies to treat bone-related diseases and defects caused by trauma. However, some of these therapies, such as administering strontium ranelate to treat osteoporosis, have significant side effects. In this context, designing new and safer strontium-based materials constitutes an important current challenge. Here, we have used quercetin as a platform to synthesize a new complex based on strontium and evaluate its activity in vitro and in vivo. First, we carried out strontium complexation with quercetin. Then, we employed Fourier transform infrared spectroscopy, nuclear magnetic resonance, and thermal gravimetric analysis to determine the chemical composition of the resulting complex as [(C",
    "authors": [
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Israel B",
            "initials": "IB",
            "lastname": "Pimenta"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Gild\u00e1cio",
            "initials": "G",
            "lastname": "Chaves Filho"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Elias G B",
            "initials": "EGB",
            "lastname": "Silva"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Lucas F B",
            "initials": "LFB",
            "lastname": "Nogueira"
        },
        {
            "affiliation": "Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeir\u00e3o Preto 14040-903, S\u00e3o Paulo, Brazil.",
            "firstname": "Tomaz Santana",
            "initials": "TS",
            "lastname": "de Mendon\u00e7a"
        },
        {
            "affiliation": "Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeir\u00e3o Preto 14040-903, S\u00e3o Paulo, Brazil.",
            "firstname": "Ta\u00edssa C S",
            "initials": "TCS",
            "lastname": "Furtado"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Paulo Cesar",
            "initials": "PC",
            "lastname": "Ferreira GasparNeto"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Luis Gustavo",
            "initials": "LG",
            "lastname": "Dias"
        },
        {
            "affiliation": "Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeir\u00e3o Preto 14040-903, S\u00e3o Paulo, Brazil.",
            "firstname": "Sandra Yasuyo",
            "initials": "SY",
            "lastname": "Fukada"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Pietro",
            "initials": "P",
            "lastname": "Ciancaglini"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, S\u00e3o Paulo, Brazil.",
            "firstname": "Ana Paula",
            "initials": "AP",
            "lastname": "Ramos"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Authors. Published by American Chemical Society.",
    "doi": "10.1021/acsomega.4c09949\n10.1016/j.drudis.2022.02.020\n10.1002/bit.28162\n10.2174/1574888x11666160921121555\n10.1021/acsbiomaterials.4c00580\n10.7150/ijms.61080\n10.1007/s43465-024-01117-3\n10.1002/jcp.26042\n10.1080/03602532.2019.1687511\n10.3390/ijms22126564\n10.1517/14740338.2014.939169\n10.1016/j.lpm.2011.07.010\n10.1016/j.actbio.2023.07.043\n10.1038/s41598-018-27461-7\n10.1021/acsbiomaterials.3c01684\n10.1021/acsbiomaterials.3c00193\n10.1016/j.msec.2021.112130\n10.1016/j.actbio.2019.05.036\n10.3390/polym16081129\n10.1088/1748-605x/ad4220\n10.1039/C8TB02045K\n10.1016/j.ijbiomac.2022.08.007\n10.1002/ptr.7010\n10.1186/s12906-021-03418-8\n10.1111/cpr.12097\n10.1179/135100004225003897\n10.1016/S1386-1425(01)00515-7\n10.1155/2014/845208\n10.1007/s10973-009-0181-6\n10.1016/j.saa.2015.07.050\n10.1016/j.saa.2008.07.030\n10.1371/journal.pone.0246265\n10.1016/j.molstruc.2021.131107\n10.1016/j.msec.2017.09.005\n10.1016/j.bcp.2006.08.021\n10.3892/etm.2015.2388\n10.1063/5.0004608\n10.1063/5.0216272\n10.1016/j.cellbi.2007.06.002\n10.1016/S0021-9258(19)52451-6\n10.1177/154405910808701207\n10.2298/jsc0710921m\n10.1080/00958972.2014.915317\n10.1016/S0010-8545(00)80009-0\n10.1042/bsr20203003\n10.56557/upjoz/2023/v44i223713\n10.3945/jn.108.102616\n10.2217/nnm-2019-0140\n10.1016/j.metabol.2003.10.022\n10.1093/rb/rbaa043\n10.4149/BLL_2017_025\n10.1016/j.jobcr.2020.04.006\n10.1371/journal.pone.0119874\n10.3389/fbioe.2024.1347811\n10.1016/j.dental.2015.12.013",
    "journal": "ACS omega",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-02-17",
    "pubmed_id": "39959088\n35227888\n35718883\n27658728\n38619014\n34790042\n38694695\n28590066\n31726891\n34207344\n25020233\n21885232\n37516416\n29907831\n38267012\n37676927\n34082947\n31125726\n38675050\n38653261\n32254857\n35934075\n33421256\n34592982\n32509200\n24617900\n15231064\n11808653\n24688439\n26172468\n18783981\n33661932\n29208278\n16996034\n26136938\n32534543\n39189657\n17689110\n14907713\n19029085\n33443286\n19244381\n31612774\n15045704\n33732489\n28814095\n32489814\n25775211\n4225675\n38665815\n26777094",
    "results": null,
    "title": "Synthesis and Characterization of a Strontium-Quercetin Complex and Its In Vitro and In Vivo Potential for Application in Bone Regeneration.",
    "xml": "<Element 'PubmedArticle' at 0x7885034b2e80>"
}