{
    "abstract": "In response to stress stimuli, cells have evolved various mechanisms to integrate internal and external signals to achieve dynamic homeostasis. Lysine acetyltransferase (KATs) and deacetyltransferase (KDACs) are the key modulators of epigenetic modifications, enabling cells to modulate cellular responses through the acetylation and deacetylation of both histone and nonhistone proteins. Understanding the signaling pathways involved in cellular stress response, along with the roles of KATs and KDACs may pave the way for the development of novel therapeutic strategies. This review discusses the molecular mechanisms of acetylation and deacetylation in stress responses related to tumorigenesis, viral and bacterial infections. In tumorigenesis section, we focused on the tumor cells' intrinsic and external molecules and signaling pathways regulated by acetylation and deacetylation modification. In viral and bacterial infections, we summarized the update research on acetylation and deacetylation modification in viral and bacterial infections, which systematical introduction on this topic is not too much. Additionally, we provide an overview of current therapeutic interventions and clinical trials involving KAT and KDAC inhibitors in the treatment of cancer, as well as viral and bacterial infection-related diseases.",
    "authors": [
        {
            "affiliation": "National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China; Guangzhou National Laboratory, Guangzhou, Guangdong 510005, China.",
            "firstname": "Lili",
            "initials": "L",
            "lastname": "Li"
        },
        {
            "affiliation": "National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China.",
            "firstname": "Yanqiong",
            "initials": "Y",
            "lastname": "Zeng"
        },
        {
            "affiliation": "Guangzhou National Laboratory, Guangzhou, Guangdong 510005, China.",
            "firstname": "Genhong",
            "initials": "G",
            "lastname": "Cheng"
        },
        {
            "affiliation": "National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China.",
            "firstname": "Heng",
            "initials": "H",
            "lastname": "Yang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Ltd. All rights reserved.",
    "doi": "10.1016/j.smim.2025.101957",
    "journal": "Seminars in immunology",
    "keywords": [
        "Acetylation",
        "Bacterial infection",
        "Deacetylation",
        "KATs",
        "KDACs",
        "Stress response",
        "Tumorigenesis",
        "Viral infection"
    ],
    "methods": null,
    "publication_date": "2025-04-27",
    "pubmed_id": "40288003",
    "results": null,
    "title": "Acetylation and deacetylation dynamics in stress response to cancer and infections.",
    "xml": "<Element 'PubmedArticle' at 0x788501efd530>"
}