{
    "abstract": "High atomic number elements-based X-ray computed tomography (CT) contrast agents offer a promising solution to address the inherent deficiencies of FDA-approved iodine contrast agents. However, they face substantial challenges in balancing imaging performance, safety, and large-scale production for clinical translation. Herein, inspired by the history of clinical gadolinium- and iodine-based contrast agents, we report a large-scale approach for synthesizing non-ionic bismuth (Bi) chelate for high-performance CT imaging in vivo. Bi-HPDO3A can be easily obtained from low-cost precursor within 4 steps at 6\u00a0g-scale. The non-ionic macrocyclic structure endows it with low osmolality, low viscosity, high stability, good renal clearable capability and biocompatibility. Additionally, Bi-HPDO3A realizes superior imaging performance across various in vivo applications, including gastrointestinal imaging, renal imaging, and computed tomography angiography (CTA). Especially, Bi-HPDO3A exhibits superior spectral imaging capability owing to the high K-edge of element Bi, achieving metal artifact-free CTA in vivo. The proposed Bi-HPDO3A that balances overall performance can serve as a high-performance CT contrast agent with potential for clinical translation.",
    "authors": [
        {
            "affiliation": "School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.",
            "firstname": "Yuping",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.",
            "firstname": "Jianqi",
            "initials": "J",
            "lastname": "Deng"
        },
        {
            "affiliation": "School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.",
            "firstname": "Mingbin",
            "initials": "M",
            "lastname": "Lang"
        },
        {
            "affiliation": "School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.",
            "firstname": "Gang",
            "initials": "G",
            "lastname": "Shu"
        },
        {
            "affiliation": "Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.",
            "firstname": "Jinbin",
            "initials": "J",
            "lastname": "Pan"
        },
        {
            "affiliation": "Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.",
            "firstname": "Cai",
            "initials": "C",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China. Electronic address: rancheng@tmu.edu.cn.",
            "firstname": "Ran",
            "initials": "R",
            "lastname": "Cheng"
        },
        {
            "affiliation": "School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China. Electronic address: shaokaisun@tmu.edu.cn.",
            "firstname": "Shao-Kai",
            "initials": "SK",
            "lastname": "Sun"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Ltd. All rights reserved.",
    "doi": "10.1016/j.biomaterials.2025.123122",
    "journal": "Biomaterials",
    "keywords": [
        "Bi chelate",
        "CT imaging",
        "Clinical translation",
        "Contrast agent",
        "Non-ionic"
    ],
    "methods": null,
    "publication_date": "2025-03-04",
    "pubmed_id": "40032441",
    "results": null,
    "title": "Large-scale synthesis of non-ionic bismuth chelate for computed tomography imaging in vivo.",
    "xml": "<Element 'PubmedArticle' at 0x7885063e9300>"
}