{
    "abstract": "Previous studies have shown tart cherry (TC) to improve exercise performance in normoxia. The effect of TC on hypoxic exercise performance is unknown. This study investigated the effects of 5 days of tart cherry (TC) or placebo (PL) supplementation on hypoxic exercise performance. Thirteen healthy participants completed an incremental cycle exercise test to exhaustion (TTE) under two conditions: (i) hypoxia (13% O2) with PL and (ii) hypoxia with TC (200 mg anthocyanin per day for 4 days and 100 mg on day 5). Pulmonary gas exchange variables, peripheral arterial oxygen saturation (SpO2), deoxygenated hemoglobin (HHb), and tissue oxygen saturation (StO2) assessed by near-infrared spectroscopy in the vastus lateralis muscle were measured at rest and during exercise. Urinary 8-hydro-2\u2032 deoxyguanosine (8-OHdG) excretion was evaluated pre-exercise and 1 and 5 h post-exercise. The TTE after TC (940 \u00b1 84 s, mean \u00b1 standard deviation) was longer than after PL (912 \u00b1 63 s, p < 0.05). During submaximal hypoxic exercise, HHb was lower and StO2 and SpO2 were higher after TC than PL. Moreover, a significant interaction (supplements \u00d7 time) in urinary 8-OHdG excretion was found (p < 0.05), whereby 1 h post-exercise increases in urinary 8-OHdG excretion tended to be attenuated after TC. These findings indicate that short-term dietary TC supplementation improved hypoxic exercise tolerance, perhaps due to lower HHb and higher StO2 in the working muscles during submaximal exercise.",
    "authors": [
        {
            "affiliation": "Faculty of Sports and Life Science, National Institute of Fitness and Sports in KANOYA, Kagoshima 8912393, Japan.\nDivision of Human Environmental Science, Mt. Fuji Research Institute, Yamanashi 4030005, Japan.",
            "firstname": "Masahiro",
            "initials": "M",
            "lastname": "Horiuchi"
        },
        {
            "affiliation": "Faculty of Health and Sports Science, Doshisha University, Kyoto 6100394, Japan.",
            "firstname": "Yoshiyuki",
            "initials": "Y",
            "lastname": "Fukuoka"
        },
        {
            "affiliation": "Faculty of Sport Science, Yamanashi Gakuin University, Yamanashi 4008575, Japan.",
            "firstname": "Katsuhiro",
            "initials": "K",
            "lastname": "Koyama"
        },
        {
            "affiliation": "Institute for Applied Human Physiology, School of Human and Behavioural Sciences, College of Human Sciences, Bangor University, Bangor LL57 2DG, UK.",
            "firstname": "Samuel J",
            "initials": "SJ",
            "lastname": "Oliver"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/nu15020388\n10.1007/s00421-018-04058-6\n10.3945/ajcn.115.123869\n10.1080/07315724.2020.1713246\n10.1186/s12970-016-0133-z\n10.1111/j.1600-0838.2009.01005.x\n10.1024/0300-9831/a000575\n10.3390/nu6020829\n10.5114/biolsport.2020.97069\n10.1093/jn/129.11.2009\n10.1016/s0300-483x(03)00328-7\n10.1096/fj.00-0703com\n10.1580/1080-6032(1999)010[0066:EOASOU]2.3.CO;2\n10.1580/1080-6032(2002)013[0094:OSIHTI]2.0.CO;2\n10.1042/CS20010065\n10.1038/sj.ejcn.1602462\n10.1046/j.1525-1373.1999.d01-145.x\n10.1161/01.HYP.38.2.274\n10.1161/hh0801.089341\n10.1097/00005344-200401000-00023\n10.1161/HYPERTENSIONAHA.107.088294\n10.1152/japplphysiol.00620.2013\n10.14814/phy2.12432\n10.1113/jphysiol.2004.079533\n10.1111/sms.13088\n10.3758/BRM.41.4.1149\n10.1177/1358863X211053381\n10.1089/ham.2016.0036\n10.14814/phy2.13475\n10.1152/japplphysiol.00627.2007\n10.1364/AO.28.002331\n10.1371/journal.pone.0085712\n10.1007/s00421-005-0017-4\n10.3389/fpsyg.2013.00863\n10.3390/nu13020459\n10.1152/japplphysiol.01414.2006\n10.1152/japplphysiol.01217.2001\n10.1152/japplphysiol.01061.2006\n10.1113/expphysiol.2007.041897\n10.1007/s00421-014-3019-2\n10.1113/jphysiol.2011.216341\n10.1152/ajpheart.00761.2009\n10.1152/ajpheart.00817.2015\n10.1161/HYPERTENSIONAHA.111.189456\n10.1113/jphysiol.2011.209486\n10.1113/jphysiol.2006.127423\n10.1113/jphysiol.2002.021477\n10.1016/j.bbrc.2010.02.136\n10.1152/japplphysiol.01253.2011\n10.1016/j.abb.2020.108408\n10.3390/nu12092755\n10.1016/S0006-2952(02)01137-1\n10.1021/jf071933i\n10.1152/ajpheart.00184.2015\n10.1080/15287399309531806",
    "journal": "Nutrients",
    "keywords": [
        "DNA damage",
        "O2 extraction",
        "antioxidant",
        "blood flow",
        "oxidative stress",
        "tissue oxygenation",
        "vasodilation"
    ],
    "methods": null,
    "publication_date": "2023-01-22",
    "pubmed_id": "36678258\n30617467\n27146650\n31986108\n27231439\n19883392\n30932750\n24566440\n33795919\n10539777\n14580789\n11344086\n10442154\n12092978\n11672451\n14736128\n16788711\n10601887\n11509489\n11325874\n14668582\n17576858\n23887898\n26109190\n15637098\n29566443\n19897823\n34809506\n27584683\n29066597\n17885024\n20555520\n24465659\n16132121\n24324449\n33573133\n17823295\n12070201\n17495116\n18245201\n25311753\n21911616\n19966056\n26801312\n22353612\n21624968\n17347273\n12205200\n20494108\n22773768\n32470460\n32927677\n12213568\n17935293\n26188020\n8230310",
    "results": null,
    "title": "Five Days of Tart Cherry Supplementation Improves Exercise Performance in Normobaric Hypoxia.",
    "xml": "<Element 'PubmedArticle' at 0x7885032d49f0>"
}