{
    "abstract": "Stent thrombosis (ST) is a serious complication of drug-eluting stent (DES) implantation regardless of the timing (acute, subacute, or late). The correlates of ST with DES are not yet completely elucidated.\nFrom a total cohort of 2974 consecutive patients treated with DES since April 2003, we identified 38 patients who presented with angiographic evidence of ST (1.27%). The ST occurred acutely in 5 patients, subacutely (< or =30 days) in 25 patients, and late (>30 days) in 8 patients. The clinical, angiographic, and procedural variables of these patients were compared with the remaining 2936 consecutive patients who underwent DES implantation and did not experience ST during a follow-up of 12 months. Logistic regression analysis was conducted to determine the correlates of ST. Compared with patients without ST, patients with ST had a higher frequency of diabetes, acute postprocedural renal failure, and chronic renal failure. There were more bifurcation lesions, type C lesions, and a trend for smaller-diameter stents. Discontinuation of clopidogrel was higher in these patients (36.8% versus 10.7%; P<0.0001). The mean duration to ST from the stent implantation was 8.9+/-8.5 days in subacute and 152.7+/-100.4 days in late thrombosis cases. Mortality was significantly higher in patients with ST compared with those without ST at 6 months (31% versus 3%; P<0.001). Multivariate analysis detected cessation of clopidogrel therapy, renal failure, bifurcation lesions, and in-stent restenosis as significant correlates of ST (P<0.05).\nST continues to be a serious complication of contemporary DES use. Careful management is warranted in patients with renal failure and in those undergoing treatment for in-stent restenosis and bifurcations. Special focus on clopidogrel compliance may minimize the incidence of ST after DES implantation.",
    "authors": [
        {
            "affiliation": "Division of Cardiology, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA.",
            "firstname": "Pramod K",
            "initials": "PK",
            "lastname": "Kuchulakanti"
        },
        {
            "affiliation": null,
            "firstname": "William W",
            "initials": "WW",
            "lastname": "Chu"
        },
        {
            "affiliation": null,
            "firstname": "Rebecca",
            "initials": "R",
            "lastname": "Torguson"
        },
        {
            "affiliation": null,
            "firstname": "Patrick",
            "initials": "P",
            "lastname": "Ohlmann"
        },
        {
            "affiliation": null,
            "firstname": "Seung-Woon",
            "initials": "SW",
            "lastname": "Rha"
        },
        {
            "affiliation": null,
            "firstname": "Leonardo C",
            "initials": "LC",
            "lastname": "Clavijo"
        },
        {
            "affiliation": null,
            "firstname": "Sang-Wook",
            "initials": "SW",
            "lastname": "Kim"
        },
        {
            "affiliation": null,
            "firstname": "Ahn",
            "initials": "A",
            "lastname": "Bui"
        },
        {
            "affiliation": null,
            "firstname": "Natalie",
            "initials": "N",
            "lastname": "Gevorkian"
        },
        {
            "affiliation": null,
            "firstname": "Zhenyi",
            "initials": "Z",
            "lastname": "Xue"
        },
        {
            "affiliation": null,
            "firstname": "Kimberly",
            "initials": "K",
            "lastname": "Smith"
        },
        {
            "affiliation": null,
            "firstname": "Jana",
            "initials": "J",
            "lastname": "Fournadjieva"
        },
        {
            "affiliation": null,
            "firstname": "William O",
            "initials": "WO",
            "lastname": "Suddath"
        },
        {
            "affiliation": null,
            "firstname": "Lowell F",
            "initials": "LF",
            "lastname": "Satler"
        },
        {
            "affiliation": null,
            "firstname": "Augusto D",
            "initials": "AD",
            "lastname": "Pichard"
        },
        {
            "affiliation": null,
            "firstname": "Kenneth M",
            "initials": "KM",
            "lastname": "Kent"
        },
        {
            "affiliation": null,
            "firstname": "Ron",
            "initials": "R",
            "lastname": "Waksman"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/CIRCULATIONAHA.105.600155",
    "journal": "Circulation",
    "keywords": [],
    "methods": null,
    "publication_date": "2006-02-24",
    "pubmed_id": "16490815",
    "results": null,
    "title": "Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents.",
    "xml": "<Element 'PubmedArticle' at 0x788502d2cc20>"
}