{
    "abstract": "Poliglecaprone-25 is a synthetic monofilament suture commonly used for post-cesarean subcuticular skin closure. The present study was designed to assess the effect of subcuticular skin closure using Monoglyde\u00ae vs. Monocryl\u00ae poliglecaprone-25 absorbable sutures on the risk of wound composite outcomes in the first 30 days post-partum [surgical site infection (SSI), wound dehiscence, hematoma or seroma].\nThis is a prospective, single-blind, randomized (1:1), multicentric, two-arm study performed between September 2020 and December 2021 at two different centers across India. Women (18-40 years) with a singleton pregnancy requiring cesarean delivery were randomized to Monoglyde\u00ae (n=62) or Monocryl\u00ae (n=62) suture groups. The primary endpoint is the incidence of wound composite outcomes in the first 30 days post-partum (SSI, wound dehiscence, seroma, or hematoma). In addition, the secondary outcomes, incidence of wound composite outcome at all visits (till four months), suture extrusion and loosening, suture removal and evaluation of microbial deposits on sutures (in case not absorbed or infection), operative time, intraoperative suture handling, postoperative pain, return to normal day-to-day activities, modified Hollander cosmesis score, subject satisfaction score, and adverse events were noted.\nNon-significant difference between the groups regarding demographic characteristics and primary endpoint; the incidence of wound composite outcome was observed. Moreover, no significant difference in suture extrusion and loosening, suture removal and evaluation of microbial deposits on sutures, operative time, intraoperative suture handling, pain, return to normal day-to-day activities, modified Hollander cosmesis, and subject satisfaction score were registered between the groups.\nThis study establishes the clinical equivalence of Monoglyde\u00ae and Monocryl\u00ae poliglecaprone-25 sutures, and both sutures can be used for subcuticular skin closure following cesarean delivery with minimal risk for wound complications.",
    "authors": [
        {
            "affiliation": "Obstetrics and Gynecology, RajaRajeswari Medical College and Hospital, Bengaluru, IND.",
            "firstname": "Mpa",
            "initials": "M",
            "lastname": "Sailakshmi"
        },
        {
            "affiliation": "Obstetrics and Gynecology, Ramakrishna Mission Seva Pratishthan Vivekananda Institute of Medical Sciences, Kolkata, IND.",
            "firstname": "Sukanta",
            "initials": "S",
            "lastname": "Misra"
        },
        {
            "affiliation": "Obstetrics and Gynecology, RajaRajeswari Medical College and Hospital, Bengaluru, IND.",
            "firstname": "Sathyashree",
            "initials": "S",
            "lastname": "Hs"
        },
        {
            "affiliation": "Obstetrics and Gynecology, Ramakrishna Mission Seva Pratishthan Vivekananda Institute of Medical Sciences, Kolkata, IND.",
            "firstname": "Soukhin",
            "initials": "S",
            "lastname": "Acharya"
        },
        {
            "affiliation": "Clinical Affairs, Healthium Medtech, Bengaluru, IND.",
            "firstname": "Ashok K",
            "initials": "AK",
            "lastname": "Moharana"
        },
        {
            "affiliation": "Clinical Affairs, Healthium Medtech, Bengaluru, IND.",
            "firstname": "Deepak",
            "initials": "D",
            "lastname": "Ts"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2023, Sailakshmi et al.",
    "doi": "10.7759/cureus.38938",
    "journal": "Cureus",
    "keywords": [
        "cesarean delivery",
        "pain score",
        "poliglecaprone-25 suture",
        "subcuticular suturing",
        "wound composite outcome"
    ],
    "methods": null,
    "publication_date": "2023-06-13",
    "pubmed_id": "37309337\n26849801\n32460720\n33030865\n31709535\n24075050\n32271475\n20816153\n28796687\n27179440\n30517329\n23262925\n25733009\n24587600\n31970125\n28077411\n24439741",
    "results": "Non-significant difference between the groups regarding demographic characteristics and primary endpoint; the incidence of wound composite outcome was observed. Moreover, no significant difference in suture extrusion and loosening, suture removal and evaluation of microbial deposits on sutures, operative time, intraoperative suture handling, pain, return to normal day-to-day activities, modified Hollander cosmesis, and subject satisfaction score were registered between the groups.",
    "title": "Clinical Equivalence of Monoglyde\u00ae and Monocryl\u00ae Absorbable Poliglecaprone-25 Sutures: A Single-Blind, Randomized Study.",
    "xml": "<Element 'PubmedArticle' at 0x7885056fc8b0>"
}