{
    "abstract": "The element iodine is an essential nutrient utilized by the thyroid glands, and deficiency of this element has been linked to reproductive failures. Iodide transporters are also present in reproductive tissues and cells of embryonic origin such as the endometrium and trophoblasts, respectively. The aim of this study is to understand if levels of iodide transporters are linked to pregnancy outcomes.\nRNA derived from endometrial biopsies from controls or women with recurrent reproductive failures was analyzed utilizing RT-PCR and targeted RNASeq.\nWhen compared to controls, women with 2 or more reproductive failures had a significant increase (>5 fold) in mRNA levels of the iodine transporters NIS and PENDRIN, but not thyroglobulin when probed vis RT-PCR. Targeted RNASeq analysis confirmed these findings when another group of patients were analyzed.\nThese findings suggest possible abnormal iodine metabolism and a deficiency of iodine in endometrial tissues from some of the women with reproductive failures. We hypothesize from these findings that inorganic iodide and/or iodine is required for optimal cellular function in reproductive tissues, and that iodide transporters may potentially be used as a marker for infertility or for probing potential localized iodine deficiency that may not present in a typical thyroid panel analysis.",
    "authors": [
        {
            "affiliation": "Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA, mahmood.bilal@rosalindfranklin.edu.\nDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA, mahmood.bilal@rosalindfranklin.edu.",
            "firstname": "Mahmood Y",
            "initials": "MY",
            "lastname": "Bilal"
        },
        {
            "affiliation": "Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.\nDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.",
            "firstname": "Svetlana",
            "initials": "S",
            "lastname": "Dambaeva"
        },
        {
            "affiliation": "Center for Holistic Medicine, West Bloomfield, Michigan, USA.",
            "firstname": "David",
            "initials": "D",
            "lastname": "Brownstein"
        },
        {
            "affiliation": "Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.\nDepartment of Obstetrics and Gynecology, Rosalind Franklin University Health System, Vernon Hills, Illinois, USA.",
            "firstname": "Joanne",
            "initials": "J",
            "lastname": "Kwak-Kim"
        },
        {
            "affiliation": "Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.\nDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.",
            "firstname": "Alice",
            "initials": "A",
            "lastname": "Gilman-Sachs"
        },
        {
            "affiliation": "Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.\nDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.",
            "firstname": "Kenneth D",
            "initials": "KD",
            "lastname": "Beaman"
        }
    ],
    "conclusions": "These findings suggest possible abnormal iodine metabolism and a deficiency of iodine in endometrial tissues from some of the women with reproductive failures. We hypothesize from these findings that inorganic iodide and/or iodine is required for optimal cellular function in reproductive tissues, and that iodide transporters may potentially be used as a marker for infertility or for probing potential localized iodine deficiency that may not present in a typical thyroid panel analysis.",
    "copyrights": "\u00a9 2020 The Author(s) Published by S. Karger AG, Basel.",
    "doi": "10.1159/000508309",
    "journal": "Medical principles and practice : international journal of the Kuwait University, Health Science Centre",
    "keywords": [
        "Endometrium",
        "Iodine",
        "PENDRIN",
        "Pregnancy failure",
        "Sodium iodide symporter"
    ],
    "methods": null,
    "publication_date": "2020-05-01",
    "pubmed_id": "32353856\n29187856\n21323596\n22108279\n10826578\n17701774\n18645607\n21401634\n28477880\n11484896\n22742605\n9296378\n9589686\n18283639\n19647627\n26152853\n15081636\n12679487\n10482376\n23272277\n21748117\n12588808\n24762031\n17584828\n23407674\n18322142\n5139919\n7262025\n27161422\n19196800",
    "results": "When compared to controls, women with 2 or more reproductive failures had a significant increase (>5 fold) in mRNA levels of the iodine transporters NIS and PENDRIN, but not thyroglobulin when probed vis RT-PCR. Targeted RNASeq analysis confirmed these findings when another group of patients were analyzed.",
    "title": "Iodide Transporters in the Endometrium: A Potential Diagnostic Marker for Women with Recurrent Pregnancy Failures.",
    "xml": "<Element 'PubmedArticle' at 0x788505181cb0>"
}