{
    "abstract": "Partial-thickness cartilage defect (PTCD) is a common and formidable clinical challenge without effective therapeutic approaches. The inherent anti-adhesive characteristics of the extracellular matrix within cartilage pose a significant impediment to the integration of cells or biomaterials with the native cartilage during cartilage repair. Here, an injectable photocrosslinked bioadhesive hydrogel, consisting of gelatin methacryloyl (GM), acryloyl-6-aminocaproic acid-g-N-hydroxysuccinimide (AN), and poly(lactic-co-glycolic acid) microspheres loaded with kartogenin (KGN) (abbreviated as GM/AN/KGN hydrogel), is designed to enhance interfacial integration and repair of PTCD. After injected in situ at the irregular defect, a stable and robust hydrogel network is rapidly formed by ultraviolet irradiation, and it can be quickly and tightly adhered to native cartilage through amide bonds. The hydrogel exhibits good adhesion strength up to 27.25 \u00b1 1.22\u00a0kPa by lap shear strength experiments. The GM/AN/KGN hydrogel demonstrates good adhesion, low swelling, resistance to fatigue, biocompatibility, and chondrogenesis properties in vitro. A rat model with PTCD exhibits restoration of a smoother surface, stable seamless integration, and abundant aggrecan and type II collagen production. The injectable stable adhesive hydrogel with long-term chondrogenic differentiation capacity shows great potential to facilitate repair of PTCD.",
    "authors": [
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.\nKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.",
            "firstname": "Qian",
            "initials": "Q",
            "lastname": "Han"
        },
        {
            "affiliation": "Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.",
            "firstname": "Jiahui",
            "initials": "J",
            "lastname": "He"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
            "firstname": "Lang",
            "initials": "L",
            "lastname": "Bai"
        },
        {
            "affiliation": "Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.",
            "firstname": "Ying",
            "initials": "Y",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Zhengzhou, 450003, China.",
            "firstname": "Baojun",
            "initials": "B",
            "lastname": "Chen"
        },
        {
            "affiliation": "Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.",
            "firstname": "Zhenlong",
            "initials": "Z",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
            "firstname": "Meiguang",
            "initials": "M",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
            "firstname": "Qiaonan",
            "initials": "Q",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
            "firstname": "Shuai",
            "initials": "S",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
            "firstname": "Nuanyang",
            "initials": "N",
            "lastname": "Wen"
        },
        {
            "affiliation": "Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. School of Medicine, Northwest University, Xi'an, 710069, China.",
            "firstname": "Jing",
            "initials": "J",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.\nKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.",
            "firstname": "Baolin",
            "initials": "B",
            "lastname": "Guo"
        },
        {
            "affiliation": "Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
            "firstname": "Zhanhai",
            "initials": "Z",
            "lastname": "Yin"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 Wiley\u2010VCH GmbH.",
    "doi": "10.1002/adhm.202303255",
    "journal": "Advanced healthcare materials",
    "keywords": [
        "adhesive hydrogel",
        "cartilage repair",
        "chondrogenic differentiation",
        "partial\u2010thickness cartilage defect"
    ],
    "methods": null,
    "publication_date": "2024-01-23",
    "pubmed_id": "38253413",
    "results": null,
    "title": "Injectable Bioadhesive Photocrosslinkable Hydrogels with Sustained Release of Kartogenin to Promote Chondrogenic Differentiation and Partial-Thickness Cartilage Defects Repair.",
    "xml": "<Element 'PubmedArticle' at 0x7885056f0900>"
}