{
    "abstract": "Abdominal Radical hysterectomy (ARH) with pelvic lymph node assessment is considered the standard treatment for early-stage cervical cancer. Accepted routes have previously included laparoscopic or robotic approaches (LRH). Laparoscopy-assisted vaginal or vaginal radical hysterectomy (LVRH) are performed in some centers. The objective of this study is to compare surgical and oncological outcomes of LVRH, to laparoscopic and abdominal approaches.\nA retrospective multicenter analysis of consecutive cervical cancer cases who underwent a radical hysterectomy between 2007 and 2017 in eleven regional cancer centers across Canada.\nA comparison of patients stratified by surgical technique was undertaken. T-test, Wilcoxon rank-sum and chi-square were used to compare patient characteristics. Log-rank tests and Cox proportional hazards models were employed to compare recurrence and survival across surgical groups.\nA total of 1071 patients with cervical cancer stage IA1 with lymphovascular invasion to stage IIIC (FIGO 2018) <4\u00a0cm were identified. Postoperative complication rate was lowest for women undergoing LVRH (9.1\u00a0%, vs 18.3\u00a0% and 22.1\u00a0% for minimally invasive and open respectively). During follow up, 114 women recurred, and 70 women died. 5-year recurrence-free survival was 85.4\u00a0% for LRH, 89.4\u00a0% for ARH and 92.2\u00a0% for LVRH. LVRH was not found to be associated with a higher risk of recurrence or death than ARH on multivariable analysis (aHR for recurrence 0.62, CI 0.21-1.77; aHR for death 0.63, CI 0.14-2.77) CONCLUSION: In this retrospective study, vaginal or laparoscopy-assisted vaginal radical hysterectomy for cervical cancer was associated with favorable perioperative and oncological outcomes.",
    "authors": [
        {
            "affiliation": "McMaster University, Juravinski Cancer Center, Hamilton, Ontario, Canada. Electronic address: laurence.bernard2@mcgill.ca.",
            "firstname": "Laurence",
            "initials": "L",
            "lastname": "Bernard"
        },
        {
            "affiliation": "McMaster University, Juravinski Cancer Center, Hamilton, Ontario, Canada.",
            "firstname": "Gregory R",
            "initials": "GR",
            "lastname": "Pond"
        },
        {
            "affiliation": "McMaster University, Juravinski Cancer Center, Hamilton, Ontario, Canada.",
            "firstname": "Laurie",
            "initials": "L",
            "lastname": "Elit"
        },
        {
            "affiliation": "University of Toronto, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.",
            "firstname": "Danielle",
            "initials": "D",
            "lastname": "Vicus"
        },
        {
            "affiliation": "University of Toronto, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.",
            "firstname": "Sabrina",
            "initials": "S",
            "lastname": "Piedimonte"
        },
        {
            "affiliation": "University of Calgary, Calgary, Alberta, Canada.",
            "firstname": "Gregg",
            "initials": "G",
            "lastname": "Nelson"
        },
        {
            "affiliation": "University of Calgary, Calgary, Alberta, Canada.",
            "firstname": "Christa",
            "initials": "C",
            "lastname": "Aubrey"
        },
        {
            "affiliation": "Laval University, Quebec City, Quebec, Canada.",
            "firstname": "Marie",
            "initials": "M",
            "lastname": "Plante"
        },
        {
            "affiliation": "Laval University, Quebec City, Quebec, Canada.",
            "firstname": "Ly-Ann",
            "initials": "LA",
            "lastname": "Teo-Fortin"
        },
        {
            "affiliation": "McGill University, Montreal, Quebec, Canada.",
            "firstname": "Susie",
            "initials": "S",
            "lastname": "Lau"
        },
        {
            "affiliation": "University of British Columbia, Vancouver, BC, Canada.",
            "firstname": "Janice",
            "initials": "J",
            "lastname": "Kwon"
        },
        {
            "affiliation": "University of British Columbia, Vancouver, BC, Canada.",
            "firstname": "Soyoun Rachel",
            "initials": "SR",
            "lastname": "Kim"
        },
        {
            "affiliation": "University of Manitoba, Winnipeg, Manitoba, Canada.",
            "firstname": "Alon D",
            "initials": "AD",
            "lastname": "Altman"
        },
        {
            "affiliation": "University of Manitoba, Winnipeg, Manitoba, Canada.",
            "firstname": "Nora-Beth",
            "initials": "NB",
            "lastname": "Mercier"
        },
        {
            "affiliation": "Dalhousie University, Halifax, NS, Canada.",
            "firstname": "Karla",
            "initials": "K",
            "lastname": "Willows"
        },
        {
            "affiliation": "Dalhousie University, Halifax, NS, Canada.",
            "firstname": "Noor",
            "initials": "N",
            "lastname": "Sadeq"
        },
        {
            "affiliation": "University of Toronto, Trillium Health Partners, Toronto, Ontario, Canada.",
            "firstname": "Tomer",
            "initials": "T",
            "lastname": "Feigenberg"
        },
        {
            "affiliation": "University of Alberta, Edmonton, Alberta, Canada.",
            "firstname": "Jeanelle",
            "initials": "J",
            "lastname": "Sabourin"
        },
        {
            "affiliation": "CHUM - Centre Hospitalier de l'Universit\u00e9 de Montreal, Montreal, Quebec, Canada.",
            "firstname": "Vanessa",
            "initials": "V",
            "lastname": "Samouelian"
        },
        {
            "affiliation": "McMaster University, Juravinski Cancer Center, Hamilton, Ontario, Canada; Tel Aviv University Faculty of Medicine, Tel Aviv, Israel.",
            "firstname": "Limor",
            "initials": "L",
            "lastname": "Helpman"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024. Published by Elsevier Ltd.",
    "doi": "10.1016/j.ejso.2024.108518",
    "journal": "European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology",
    "keywords": [
        "Cervical cancer",
        "Radical hysterectomy",
        "Vaginal surgery"
    ],
    "methods": null,
    "publication_date": "2024-08-09",
    "pubmed_id": "39116514",
    "results": null,
    "title": "Safety of vaginal surgery for early-stage cervical cancer: A retrospective multicenter cohort study.",
    "xml": "<Element 'PubmedArticle' at 0x788505c912b0>"
}