{
    "abstract": "Although current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ventricular-pulmonary arterial coupling. The aim of this study was to investigate exercise-induced changes in echocardiographic variables of RV function or RV- arterial coupling in patients with residual thrombotic defects at 3 months after PE. This retrospective study investigated patients with residual thromboembolic disease on V/Q scintigraphy with persistent symptoms despite adequate anticoagulation after 3 months of acute PE, and resting echocardiography with a low probability of PH. At rest and during exercise, CPET and doppler echocardiography were performed following a standard protocol. Forty-five patients were included, completing a follow-up period of at least 24 months. The mean (standard deviation) age was 63 (15) years, and 24 (53%) patients were male. Four patients developed CTEPH after 2 years follow up. Correlation analyses showed that the peak TAPSE was significantly associated with peak workload (",
    "authors": [
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.",
            "firstname": "Karys",
            "initials": "K",
            "lastname": "Khilzi"
        },
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.\nHospital Del Mar Research Institute Barcelona Spain.",
            "firstname": "Lucilla",
            "initials": "L",
            "lastname": "Piccari"
        },
        {
            "affiliation": "Department of Medicine and Life Sciences (MELIS) Universitat Pompeu Fabra (UPF) Barcelona Spain.",
            "firstname": "Gerard",
            "initials": "G",
            "lastname": "Franco"
        },
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.\nDepartment of Medicine and Life Sciences (MELIS) Universitat Pompeu Fabra (UPF) Barcelona Spain.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Rod\u00f3-Pin"
        },
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Herranz"
        },
        {
            "affiliation": "Department of Pulmonary Medicine, Hospital Cl\u00ednic-Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona Barcelona Spain.\nCentro de Investigaci\u00f3n en Red de Enfermedades Respiratorias, (CIBERES) Instituto de Salud Carlos III (ISCIII) Barcelona Madrid Spain.",
            "firstname": "Isabel",
            "initials": "I",
            "lastname": "Blanco"
        },
        {
            "affiliation": "Dipartimento Cardio-Toraco-Vascolare Fondazione IRCCS San Gerardo dei Tintori Universit\u00e0 Milano Bicocca Monza (MB) Monza Italy.",
            "firstname": "Giuseppe",
            "initials": "G",
            "lastname": "Paciocco"
        },
        {
            "affiliation": "Dipartimento Cardio-Toraco-Vascolare Fondazione IRCCS San Gerardo dei Tintori Universit\u00e0 Milano Bicocca Monza (MB) Monza Italy.",
            "firstname": "Lorenzo",
            "initials": "L",
            "lastname": "Volpiano"
        },
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.",
            "firstname": "Jose",
            "initials": "J",
            "lastname": "Gonzalez Garcia"
        },
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.",
            "firstname": "Ana",
            "initials": "A",
            "lastname": "Diez-Llaneza"
        },
        {
            "affiliation": "Hospital Del Mar Research Institute Barcelona Spain.\nDepartment of Medicine and Life Sciences (MELIS) Universitat Pompeu Fabra (UPF) Barcelona Spain.\nCardiology Department Hospital del Mar Barcelona Spain.",
            "firstname": "Lluis",
            "initials": "L",
            "lastname": "Molina"
        },
        {
            "affiliation": "Pulmonology Department-Hospital del Mar Pulmonary Hypertension Unit Barcelona Spain.\nHospital Del Mar Research Institute Barcelona Spain.\nDepartment of Medicine and Life Sciences (MELIS) Universitat Pompeu Fabra (UPF) Barcelona Spain.\nCentro de Investigaci\u00f3n en Red de Enfermedades Respiratorias, (CIBERES) Instituto de Salud Carlos III (ISCIII) Barcelona Madrid Spain.",
            "firstname": "Diego A",
            "initials": "DA",
            "lastname": "Rodr\u00edguez Chiarad\u00eda"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.",
    "doi": "10.1002/pul2.70045\n10.1183/13993003.00879-2022\n10.1056/NEJMoa032274\n10.1183/13993003.01792-2016\n10.3324/haematol.2009.018960\n10.1093/eurheartj/ehac206\n10.1016/j.thromres.2023.05.005\n10.1136/thorax-2023-220580\n10.1183/13993003.00059-2023\n10.1016/j.chest.2016.11.030\n10.1016/j.chest.2019.10.047\n10.1161/CIRCULATIONAHA.113.001573\n10.14814/phy2.13227\n10.1016/j.jchf.2022.11.004\n10.1093/ehjci/jev014\n10.1016/j.hlc.2016.10.015\n10.1016/j.arbres.2021.01.031\n10.1161/JAHA.117.006841\n10.1016/j.jcmg.2015.06.018\n10.1183/16000617.0132-2022\n10.1093/eurheartj/ehz405\n10.1159/000447247\n10.1152/ajpheart.00157.2013\n10.1161/CIRCIMAGING.119.009047\n10.1378/chest.14-2065\n10.3389/fphys.2020.00964\n10.1111/echo.13396\n10.1136/bmjresp-2023-001637",
    "journal": "Pulmonary circulation",
    "keywords": [
        "exercise capacity",
        "post\u2010PE syndrome",
        "right ventricular function"
    ],
    "methods": null,
    "publication_date": "2025-02-07",
    "pubmed_id": "39917073\n36028254\n15163775\n28232411\n20053871\n35484821\n37263121\n38050187\n36958742\n27932051\n31759962\n24056689\n28373412\n36754531\n25712077\n27988278\n33714657\n29502109\n26508387\n36754432\n31504429\n27327769\n23997100\n31500448\n25633590\n32848882\n27696506\n37491130",
    "results": null,
    "title": "Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism.",
    "xml": "<Element 'PubmedArticle' at 0x7885040f2b10>"
}