{
    "abstract": "Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (",
    "authors": [
        {
            "affiliation": "Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Justyna",
            "initials": "J",
            "lastname": "Popi\u00f3\u0142"
        },
        {
            "affiliation": "Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Agnieszka",
            "initials": "A",
            "lastname": "Gunia-Krzy\u017cak"
        },
        {
            "affiliation": "Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Karolina",
            "initials": "K",
            "lastname": "S\u0142oczy\u0144ska"
        },
        {
            "affiliation": "Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Paulina",
            "initials": "P",
            "lastname": "Koczurkiewicz-Adamczyk"
        },
        {
            "affiliation": "Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Kamil",
            "initials": "K",
            "lastname": "Piska"
        },
        {
            "affiliation": "Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Katarzyna",
            "initials": "K",
            "lastname": "W\u00f3jcik-Pszczo\u0142a"
        },
        {
            "affiliation": "Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Dorota",
            "initials": "D",
            "lastname": "\u017belaszczyk"
        },
        {
            "affiliation": "Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Krupa"
        },
        {
            "affiliation": "Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Pawe\u0142",
            "initials": "P",
            "lastname": "\u017bmudzki"
        },
        {
            "affiliation": "Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "Henryk",
            "initials": "H",
            "lastname": "Marona"
        },
        {
            "affiliation": "Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krak\u00f3w, Poland.",
            "firstname": "El\u017cbieta",
            "initials": "E",
            "lastname": "P\u0119kala"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ijms22010034\n10.1159/000087606\n10.1016/j.envint.2014.05.015\n10.3390/cancers2041980\n10.1210/en.2004-1272\n10.2533/chimia.2008.345\n10.1111/ics.12030\n10.1201/b14170\n10.1021/acs.jpclett.7b00633\n10.1080/14756366.2016.1265523\n10.3390/molecules24122321\n10.1111/ics.12471\n10.1111/ics.12165\n10.1039/b9pp00174c\n10.1039/C5PP00074B\n10.1016/j.arabjc.2017.01.006\n10.1038/ja.2016.36\n10.1021/jm020929p\n10.2174/1871520619666190405113519\n10.1515/hc-2017-0215\n10.1517/13543776.2013.836182\n10.1016/j.ejphar.2012.05.050\n10.1016/j.jphotobiol.2015.08.014\n10.1016/j.bmcl.2019.126679\n10.1002/chin.198111249\n10.1039/jr9580001790\n10.1002/jps.2600820103\n10.1002/1522-2675(20010321)84:33.0.CO;2-X\n10.1002/ardp.200700156\n10.1002/ardp.200800089\n10.1038/208537a0\n10.1002/bmc.1153\n10.1248/bpb.17.1421\n10.1691/ph.2007.6.6247\n10.1016/j.ijpharm.2015.03.077\n10.1111/j.1467-2494.2007.00340_2.x\n10.1039/b516702g\n10.1016/j.ijpharm.2011.01.040\n10.1016/j.jdermsci.2008.06.010\n10.1080/10837450802683966\n10.1016/j.ijpharm.2005.08.029\n10.1289/ehp.01109239\n10.1002/cber.190503802155\n10.1002/(SICI)1521-4184(199805)331:5<177::AID-ARDP177>3.0.CO;2-K\n10.1016/j.jphotobiol.2015.04.007\n10.1016/j.mrgentox.2003.12.001\n10.1016/j.mrgentox.2012.03.014\n10.1002/em.20504\n10.1002/em.21677\n10.1016/j.mrgentox.2012.07.006",
    "journal": "International journal of molecular sciences",
    "keywords": [
        "(E)-cinnamoyl",
        "UV absorption",
        "UV filters",
        "UV radiation",
        "photoprotective activity",
        "xanthone"
    ],
    "methods": null,
    "publication_date": "2020-12-31",
    "pubmed_id": "33375127\n16113595\n24934855\n24281212\n15705771\n23237547\n28437110\n28114824\n31238526\n29870052\n25256657\n20354639\n26035445\n27025351\n12383019\n30950354\n24066838\n22683868\n26318281\n31537425\n3489931\n8429484\n18240129\n19051197\n19277952\n7874070\n17663193\n25843762\n16520862\n21277959\n18755574\n19630696\n16289662\n11333184\n9691249\n6604908\n11487977\n25920069\n15036131\n22579797\n19484728\n22246666\n22989744",
    "results": null,
    "title": "The Involvement of Xanthone and (",
    "xml": "<Element 'PubmedArticle' at 0x788504d6a610>"
}