{
    "abstract": "This study aimed to evaluate the incidence of cross-border reproductive care (CBRC) and maternal and neonatal outcomes in pregnancies conceived through in vitro fertilization (IVF), comparing outcomes between pregnancies conceived domestically and through CBRC.\nA retrospective chart review was conducted on 4475 deliveries at a tertiary public hospital from February 1, 2023, to January 31, 2024. Maternal demographics, medical history, delivery outcomes, and complications were compared using statistical tests, with significance set at p\u2009<\u20090.05.\nAmong all deliveries, 95 were conceived via IVF. Among the IVF pregnancies, 23 (24.2%) were conceived through CBRC. While CBRC patients were older on average (40.3 vs. 37.8\u00a0years), this difference was not statistically significant (p\u2009=\u20090.07). The incidence of hypertensive disorders was significantly higher in CBRC pregnancies compared to domestic IVF pregnancies (69.6% vs. 37.7%, p\u2009=\u20090.01). Trends toward increased rates of postpartum hemorrhage (17.4% vs. 5.8%) and multiple gestations (26.1% vs. 11.6%) were also observed in the CBRC group, although these differences did not reach statistical significance. Neonatal outcomes, including rates of preterm birth, fetal growth restriction, and respiratory distress syndrome, were similar between the two groups.\nThe study highlights a significantly higher percentage of hypertensive disorders among CBRC pregnancies, while other maternal and neonatal outcomes were comparable to domestic IVF pregnancies. These findings underscore the need for further research with larger sample sizes and survey-based studies to better understand patient motivations and clinical risks associated with CBRC.",
    "authors": [
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA. Sxr785@med.miami.edu.",
            "firstname": "Suset",
            "initials": "S",
            "lastname": "Rodriguez"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA.",
            "firstname": "Kyara",
            "initials": "K",
            "lastname": "Marquez"
        },
        {
            "affiliation": "New York University Grossman School of Medicine, New York, NY, USA.",
            "firstname": "Gemma St",
            "initials": "GS",
            "lastname": "Louis"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA.",
            "firstname": "Arianna",
            "initials": "A",
            "lastname": "Vazquez"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA.",
            "firstname": "Leonardo",
            "initials": "L",
            "lastname": "Simonelli"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA.",
            "firstname": "Kara",
            "initials": "K",
            "lastname": "Lindsay"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA.",
            "firstname": "Janice",
            "initials": "J",
            "lastname": "Moscoso"
        },
        {
            "affiliation": "University of Miami Miller School of Medicine, Miami, FL, USA.",
            "firstname": "George Roshdy",
            "initials": "GR",
            "lastname": "Attia"
        }
    ],
    "conclusions": "The study highlights a significantly higher percentage of hypertensive disorders among CBRC pregnancies, while other maternal and neonatal outcomes were comparable to domestic IVF pregnancies. These findings underscore the need for further research with larger sample sizes and survey-based studies to better understand patient motivations and clinical risks associated with CBRC.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1007/s10815-025-03449-x",
    "journal": "Journal of assisted reproduction and genetics",
    "keywords": [
        "Cross-border reproductive care",
        "Global health",
        "In vitro fertilization",
        "Reproductive traveling"
    ],
    "methods": null,
    "publication_date": "2025-03-22",
    "pubmed_id": "40119090\n28916332\n21498121\n20348165\n21130988\n24018235\n26316832\n20149916\n20566536\n21955490\n22366965\n21840759\n21955489\n31112853\n19614936\n28369720\n29040334\n31337350\n20206927\n19726447\n25593693\n27083429",
    "results": "Among all deliveries, 95 were conceived via IVF. Among the IVF pregnancies, 23 (24.2%) were conceived through CBRC. While CBRC patients were older on average (40.3 vs. 37.8\u00a0years), this difference was not statistically significant (p\u2009=\u20090.07). The incidence of hypertensive disorders was significantly higher in CBRC pregnancies compared to domestic IVF pregnancies (69.6% vs. 37.7%, p\u2009=\u20090.01). Trends toward increased rates of postpartum hemorrhage (17.4% vs. 5.8%) and multiple gestations (26.1% vs. 11.6%) were also observed in the CBRC group, although these differences did not reach statistical significance. Neonatal outcomes, including rates of preterm birth, fetal growth restriction, and respiratory distress syndrome, were similar between the two groups.",
    "title": "Incidence of cross-border reproductive care and pregnancy outcomes: a retrospective evaluation of IVF conceptions.",
    "xml": "<Element 'PubmedArticle' at 0x788506840220>"
}