{
    "abstract": "Lower urinary tract symptoms (LUTS) are common in postmenopausal women. These symptoms are often linked to decreased estrogen levels following menopause. This study investigated the relationship between estrogen levels, alterations in bladder tissue structure, bladder function, and the incidence of urinary frequency. An age-appropriate bilateral ovariectomized mouse model (OVX) was developed to simulate conditions of estrogen deficiency. Mice were divided into three groups: a sham-operated control group, OVX, and an estradiol-treated group. The assessments included estrogen level measurement, urination frequency, cystometry, histological analysis, immunofluorescence staining, and real-time quantitative PCR. Additionally, we quantified the expression of the mechanosensitive channel proteins ",
    "authors": [
        {
            "affiliation": "Guangxi Key Laboratory of Special Biomedicine and Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning 530004, China.",
            "firstname": "Chenglong",
            "initials": "C",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai 200052, China.",
            "firstname": "Yuangui",
            "initials": "Y",
            "lastname": "Chen"
        },
        {
            "affiliation": "Guangxi Key Laboratory of Special Biomedicine and Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning 530004, China.",
            "firstname": "Lingxuan",
            "initials": "L",
            "lastname": "Yin"
        },
        {
            "affiliation": "Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai 200052, China.",
            "firstname": "Guoxian",
            "initials": "G",
            "lastname": "Deng"
        },
        {
            "affiliation": "Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai 200052, China.",
            "firstname": "Xiaowen",
            "initials": "X",
            "lastname": "Xia"
        },
        {
            "affiliation": "Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai 200052, China.",
            "firstname": "Xiaoshuang",
            "initials": "X",
            "lastname": "Tang"
        },
        {
            "affiliation": "Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai 200052, China.",
            "firstname": "Yifeng",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Guangxi Key Laboratory of Special Biomedicine and Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning 530004, China.\nDepartment of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai 200052, China.",
            "firstname": "Junan",
            "initials": "J",
            "lastname": "Yan"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/biom14091044\n10.1038/s41598-020-76846-0\n10.1016/j.jfma.2018.03.006\n10.1016/0378-5122(95)00958-2\n10.1097/GME.0000000000002187\n10.1080/13697137.2023.2184251\n10.1097/GME.0000000000001741\n10.1177/1754045313511398\n10.1002/nau.21106\n10.1111/j.1464-410X.2007.06532.x\n10.1152/ajprenal.00214.2019\n10.1172/jci.insight.152984\n10.1074/jbc.M113.528638\n10.3389/fpain.2021.748385\n10.1111/brv.12814\n10.1113/JP279776\n10.1016/j.juro.2011.04.107\n10.1172/JCI31766\n10.1016/j.eururo.2018.05.020\n10.1152/ajpregu.00008.2014\n10.1172/JCI123689\n10.1016/j.ecoenv.2022.113927\n10.1038/s41401-022-00968-6\n10.1002/jcp.26541\n10.1111/j.1464-410X.2012.11189.x\n10.1152/ajpheart.00645.2015\n10.3390/nu8030176\n10.1002/nau.20438\n10.1124/jpet.109.155010\n10.1016/S0024-3205(02)01645-4\n10.1016/S0024-3205(99)00168-X\n10.1097/01.gme.0000227401.98933.0b\n10.1016/S0022-5347(05)64637-X\n10.1111/j.1464-410X.2004.05174.x\n10.1007/s00345-019-03008-x\n10.1016/j.juro.2006.07.131\n10.1016/j.juro.2009.05.126\n10.1016/S0022-5347(05)65935-6\n10.4111/icu.2020.61.4.432\n10.1677/joe.1.06701\n10.1016/j.urology.2004.06.014\n10.1016/j.plefa.2008.11.010\n10.1111/j.1464-410X.2008.07746.x\n10.1016/S0022-5347(17)32685-X\n10.1267/ahc.33.131\n10.3892/ijmm.2019.4434\n10.1016/j.maturitas.2007.09.010\n10.1016/j.maturitas.2008.07.015\n10.1097/01.ju.0000068723.05004.ca\n10.1152/ajpcell.2001.280.3.C433\n10.1023/A:1007834708642\n10.3390/polym13162642\n10.1016/j.bbadis.2019.05.008\n10.1016/j.abb.2020.108674\n10.1002/jcb.28852\n10.1152/ajprenal.00599.2009\n10.3389/fphys.2021.762847\n10.1002/nau.23793\n10.1096/fj.201900961RR\n10.1038/s41598-018-23115-w",
    "journal": "Biomolecules",
    "keywords": [
        "Piezo1",
        "TRPV4",
        "collagen deposition",
        "estrogen",
        "voiding frequency"
    ],
    "methods": null,
    "publication_date": "2024-09-28",
    "pubmed_id": "39334811\n33188254\n29655606\n8775772\n37192832\n36912363\n33739310\n24336244\n21661025\n17227500\n31166705\n34464353\n24759099\n35295484\n34781417\n33052604\n21784462\n17948126\n29875065\n24965792\n31063987\n35908533\n35986213\n29672850\n22540742\n26993224\n28135243\n27007393\n17480029\n19515967\n12034352\n10372661\n16946685\n12187279\n15610122\n31712957\n17085203\n19692014\n11490312\n32666001\n16899558\n15533516\n19181506\n18485034\n8021999\n31894295\n18022774\n18845407\n12853846\n11171561\n10935152\n34451183\n31102789\n33189652\n31069835\n20015940\n35069237\n30106187\n31914645\n29632308",
    "results": null,
    "title": "Investigating the Impact of Estrogen Levels on Voiding Characteristics, Bladder Structure, and Related Proteins in a Mouse Model of Menopause-Induced Lower Urinary Tract Symptoms.",
    "xml": "<Element 'PubmedArticle' at 0x78850297a520>"
}