{
    "abstract": "Fatty acids are a requirement for normal development, however, since humans are unable to de novo produce essential fatty acids, they must be obtained from diet. Atlantic salmon is a major dietary source of nutritious and digestible fatty acids. Here, we set out to uncover the genomic basis of individual fatty acids and indices (saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, n-3, and n-6) in 208 North American Atlantic salmon, to understand selection potential toward increasing relative quantities of essential fatty acids and to identify candidate genes for future research. Total n-6 (pro-inflammatory) was higher than total n-3 (anti-inflammatory) fatty acids with a ratio of 1 : 1.31 (n-3 : n-6). Heritability of fatty acids ranged from 0 to 0.99, however, most fatty acids and indices had moderate to high heritabilities (ranged from 0.20 to 0.88), implying that selection for improvement of traits could be possible. We found the same significant markers on chromosome 23 (based on false discovery rate thresholds of 2.0e-6 and suggestive significant thresholds of 2.0e-5 in Manhattan plots) in four fatty acids (\u03b3-linoleic acid, stearidonic acid, dihimo-\u03b3-linolenic acid, and eicosatrienoic acid), where three genes (sin3b, acbd6, and fads2) are known to be involved in lipid metabolism. These genes, fads2 in particular, would all make ideal candidates for future functional studies. In addition, there were four fatty acids with loci over the suggestive significant threshold with a variety of markers on different chromosomes (lauric acid, stearic acid, eicosatetraenoic acid (ETA), and docosadienoic acid), with associated genes that had relevant functions to fatty acids or adipose cells in general.",
    "authors": [
        {
            "affiliation": "The Huntsman Marine Science Centre, 1 Lower Campus Rd., St. Andrews, NB E5B 2L7, Canada. Barbara.Langille@huntsmanmarine.ca.",
            "firstname": "Barbara L",
            "initials": "BL",
            "lastname": "Langille"
        },
        {
            "affiliation": "Agriculture and Agri-Food Canada Lacombe Research and Development Centre, 6000 C and E Trail, Lacombe, AB T4L 1W1, Canada.",
            "firstname": "Manuel",
            "initials": "M",
            "lastname": "Ju\u00e1rez"
        },
        {
            "affiliation": "Agriculture and Agri-Food Canada Lacombe Research and Development Centre, 6000 C and E Trail, Lacombe, AB T4L 1W1, Canada.",
            "firstname": "Nuria",
            "initials": "N",
            "lastname": "Prieto"
        },
        {
            "affiliation": "Mowi Genetics AS, Sandviksbodene 77A, Bergen, 5035, Norway.",
            "firstname": "Solomon",
            "initials": "S",
            "lastname": "Boison"
        },
        {
            "affiliation": "Mowi Genetics AS, Sandviksbodene 77A, Bergen, 5035, Norway.",
            "firstname": "Panya Sae",
            "initials": "PS",
            "lastname": "Lim"
        },
        {
            "affiliation": "Tri-Gen Fish Improvement Ltd., Site 13 Comp 27 RR1, Lacombe, AB, T4L 2N1, Canada.",
            "firstname": "Bruce D",
            "initials": "BD",
            "lastname": "Swift"
        },
        {
            "affiliation": "The Huntsman Marine Science Centre, 1 Lower Campus Rd., St. Andrews, NB E5B 2L7, Canada.",
            "firstname": "Amber F",
            "initials": "AF",
            "lastname": "Garber"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s12864-024-11131-2",
    "journal": "BMC genomics",
    "keywords": [
        "fads2",
        "Fatty acid",
        "Omega",
        "Selective breeding"
    ],
    "methods": null,
    "publication_date": "2024-12-19",
    "pubmed_id": "39695999\n35075379\n26899924\n25985885\n23887675\n29204906\n29715470\n15750663\n17194275\n19136835\n20382009\n26139350\n24156620\n26589139\n28615065\n22785162\n27023885\n34573305\n13428781\n9655369\n17492324\n37335943\n17701901\n27601374\n34791404\n30944313\n29783944\n24315800\n21732068\n21036930\n21535766\n22332096\n25149823\n21666970\n27475083\n31954333\n37893916\n37970507\n29720078\n28132119\n26769304\n30254373\n36551154\n26027376\n0\n29575257\n30215728\n12865422\n12031478\n20618965\n34732127\n20451480\n26960694\n27308327\n24785298\n36352447\n10699171\n31740454\n27666082\n31708975\n27097669\n26796620\n30584983\n34438882",
    "results": null,
    "title": "Candidate genes associated with fatty acid compositions in north American Atlantic salmon (Salmo salar).",
    "xml": "<Element 'PubmedArticle' at 0x788503898f40>"
}