{
    "abstract": "The use of continuous flow left ventricular assist device (CF-LVAD) has revolutionized the management of advanced heart failure. One of the major complications associated with its use is the risk of bleeding, especially in the early postoperative period. Early events of postoperative bleeding have been associated with higher morbidity and mortality rates. Our study aims at identifying potential predictors of intraoperative bleeding, defined as 4 or more units of packed red blood cells\u00a0transfused during surgery. A single-center retrospective cohort study of adult patients older than 18\u00a0years old who underwent CF-LVAD implantation between 2009 and 2024.\nData were collected for the duration of implant hospitalization, including perioperative invasive hemodynamics, echocardiography, operative details, mechanical circulatory support, antiplatelets, inotropes, bleeding events, and blood product use, in addition to patient history and baseline characteristics.\nA total of 208 patients were included in the analysis. Intraoperative bleeding occurred in 43 (20.67%) patients while 165 (79.33%) patients did not experience bleeding. Multilogistic regression analysis showed that artery bypass grafting pre-LVAD (odds ratio [OR] 2.98, confidence interval [CI] 1.2-7.42, \nHistory of coronary artery bypass grafting and mechanical circulatory support before the implantation of LVAD are independent predictors of intraoperative bleeding during hospitalization in these patients. Intraoperative bleeding is associated with higher frequency of right ventricle failure post-LVAD and higher 90-day mortality.",
    "authors": [
        {
            "affiliation": "Division of Cardiology, Department of Medicine, University of Iowa, Iowa City, Iowa.",
            "firstname": "Ibrahim",
            "initials": "I",
            "lastname": "Mortada"
        },
        {
            "affiliation": "Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece.",
            "firstname": "Christos",
            "initials": "C",
            "lastname": "Kourek"
        },
        {
            "affiliation": "Division of Cardiology, Department of Medicine, University of Iowa, Iowa City, Iowa.",
            "firstname": "Rupesh",
            "initials": "R",
            "lastname": "Kshetri"
        },
        {
            "affiliation": "Department of Cardiovascular Surgery, University of Iowa, Iowa City, Iowa.",
            "firstname": "Arun",
            "initials": "A",
            "lastname": "Singhal"
        },
        {
            "affiliation": "Department of Cardiovascular Surgery, University of Iowa, Iowa City, Iowa.",
            "firstname": "Anthony",
            "initials": "A",
            "lastname": "Panos"
        },
        {
            "affiliation": "Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece.",
            "firstname": "Alexandros",
            "initials": "A",
            "lastname": "Briasoulis"
        },
        {
            "affiliation": "Division of Cardiology, Department of Medicine, University of Iowa, Iowa City, Iowa.",
            "firstname": "Mohammed",
            "initials": "M",
            "lastname": "Mhanna"
        },
        {
            "affiliation": "Division of Cardiology, Department of Medicine, University of Iowa, Iowa City, Iowa.",
            "firstname": "Shareef",
            "initials": "S",
            "lastname": "Mansour"
        },
        {
            "affiliation": "Division of Cardiology, Department of Medicine, University of Iowa, Iowa City, Iowa.",
            "firstname": "Kristine",
            "initials": "K",
            "lastname": "Yumul"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.\nCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.",
            "firstname": "Paulino",
            "initials": "P",
            "lastname": "Alvarez"
        },
        {
            "affiliation": "Division of Cardiology, Department of Medicine, University of Iowa, Iowa City, Iowa.",
            "firstname": "Ernesto",
            "initials": "E",
            "lastname": "Ruiz Duque"
        }
    ],
    "conclusions": "History of coronary artery bypass grafting and mechanical circulatory support before the implantation of LVAD are independent predictors of intraoperative bleeding during hospitalization in these patients. Intraoperative bleeding is associated with higher frequency of right ventricle failure post-LVAD and higher 90-day mortality.",
    "copyrights": "\u00a9 2025 International Society for Heart and Lung Transplantation.",
    "doi": "10.1016/j.jhlto.2024.100195",
    "journal": "JHLT open",
    "keywords": [
        "LVAD",
        "bleeding",
        "heart failure",
        "mechanical circulatory support",
        "survival"
    ],
    "methods": null,
    "publication_date": "2025-03-27",
    "pubmed_id": "40144841\n30883052\n28942782\n32386998\n21352991\n29481654\n36074476\n19920051\n26809087\n23401115\n32340871\n37950897\n22532765\n28146651\n29543629\n29939246\n27654344\n20007735\n32999142\n27653165\n26330426\n15797109\n15466654\n18574269\n21282503\n38878021\n37344249\n24332097\n28948385\n18930659\n25790208\n30932171\n7814888\n15673408\n16434264",
    "results": "A total of 208 patients were included in the analysis. Intraoperative bleeding occurred in 43 (20.67%) patients while 165 (79.33%) patients did not experience bleeding. Multilogistic regression analysis showed that artery bypass grafting pre-LVAD (odds ratio [OR] 2.98, confidence interval [CI] 1.2-7.42, ",
    "title": "Prevalence, risk factors, and prognostic implications of intraoperative bleeding during CF-LVAD implant.",
    "xml": "<Element 'PubmedArticle' at 0x788505737f60>"
}