{
    "abstract": "Limited data are available regarding the use of the antifibrinolytic drugs tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in cats. This study aimed to evaluate the indications for the use of TXA and EACA in cats and to describe dosing regimens used, occurrence of adverse events, and patient outcomes. This was a retrospective multicenter study. Medical databases were searched for feline patients billed for TXA or EACA between 2015 and 2021. Thirty-five cats met the inclusion criteria; 86% received TXA and 14% received EACA. The most common indication was nontraumatic hemorrhage (54%), followed by traumatic hemorrhage (17%) and elective surgery (11%). The median dose was 10 mg/kg for TXA and 50 mg/kg for EACA. Overall, 52% of cats survived to discharge. Potential adverse events were noted in 7/35 (20%) patients. Of these, 29% survived to discharge. No standardized dosing regimen was identified; rather, dose, dosing interval, and duration of administration varied markedly between patients. Administration was potentially associated with severe adverse events, although the retrospective design makes it difficult to establish a causal association with antifibrinolytic use. This study provides a base for future prospective studies by giving an insight into the use of antifibrinolytic drugs in cats.",
    "authors": [
        {
            "affiliation": "From AniCura Regiondjursjukhuset Bagarmossen, Stockholm, Sweden (L.W.).\nDick White Referrals, Cambridgeshire, UK (L.W., G.S., E.K.T.).",
            "firstname": "Lotta",
            "initials": "L",
            "lastname": "Wahld\u00e9n"
        },
        {
            "affiliation": "Dick White Referrals, Cambridgeshire, UK (L.W., G.S., E.K.T.).",
            "firstname": "Giacomo",
            "initials": "G",
            "lastname": "Stanzani"
        },
        {
            "affiliation": "Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, UK (S.M.C.).",
            "firstname": "Simone",
            "initials": "S",
            "lastname": "Cutler"
        },
        {
            "affiliation": "Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, UK (D.B.).",
            "firstname": "Dominic",
            "initials": "D",
            "lastname": "Barfield"
        },
        {
            "affiliation": "Cummings School of Veterinary Medicine, Tufts University, Grafton, Massachusetts (K.C.M.).",
            "firstname": "Katrina C",
            "initials": "KC",
            "lastname": "Manson"
        },
        {
            "affiliation": "Langford Vets, University of Bristol, Bristol, UK (H.E.W.).",
            "firstname": "Helen E",
            "initials": "HE",
            "lastname": "Wilson"
        },
        {
            "affiliation": "Dick White Referrals, Cambridgeshire, UK (L.W., G.S., E.K.T.).",
            "firstname": "Emily K",
            "initials": "EK",
            "lastname": "Thomas"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023 by American Animal Hospital Association.",
    "doi": "10.5326/JAAHA-MS-7349",
    "journal": "Journal of the American Animal Hospital Association",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-07-11",
    "pubmed_id": "37432789",
    "results": null,
    "title": "Evaluation of Therapeutic Use of Antifibrinolytics in Cats.",
    "xml": "<Element 'PubmedArticle' at 0x788505db5620>"
}