{
    "abstract": "Peptide-based neoantigen vaccines are promising cancer immunotherapy strategies because of their capability to induce durable tumor-specific immune responses. However, insufficient neoantigen-specific T-lymphocyte activation greatly limits their clinical efficacy. Here, we developed sericin-coordinated zinc ion-modified calcium phosphate (CP) nanovaccines that codeliver tumor antigen peptides and a Toll-like receptor 9 agonist (SZCP/APs-CpG) for potentiating antigen-specific T cell immunity. SZCP/APs-CpG nanovaccines could yield efficient codelivery of antigen peptides and adjuvants to dendritic cells (DCs) in draining lymph nodes (dLNs), induce hyperactive DCs depending on the inflammasome-dependent interleukin-1\u03b2 secretion, and coordinate the released Zn",
    "authors": [
        {
            "affiliation": "Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Lei",
            "initials": "L",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Xinbo",
            "initials": "X",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Hongyan",
            "initials": "H",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Feng",
            "initials": "F",
            "lastname": "Liu"
        },
        {
            "affiliation": "Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Zheng",
            "initials": "Z",
            "lastname": "Dai"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.",
            "firstname": "Fang",
            "initials": "F",
            "lastname": "Xiao"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Lin",
            "initials": "L",
            "lastname": "Wang"
        },
        {
            "affiliation": "Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.\nHubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Wuhan 430022, China.\nHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Wuhan 430022, China.",
            "firstname": "Zheng",
            "initials": "Z",
            "lastname": "Wang"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1021/acsnano.4c17491",
    "journal": "ACS nano",
    "keywords": [
        "calcium phosphate",
        "cancer immunotherapy",
        "hyperactive DCs",
        "inflammasome",
        "nanovaccines"
    ],
    "methods": null,
    "publication_date": "2025-04-03",
    "pubmed_id": "40177975",
    "results": null,
    "title": "Zinc Ion-Coordinated Sericin Calcium Phosphate Nanovaccines Induce Hyperactive Dendritic Cells and Synergistic Activation of T Cells for Cancer Immunotherapy.",
    "xml": "<Element 'PubmedArticle' at 0x78850577f470>"
}