{
    "abstract": "To overcome problems associated with surgical site infection and implant loosening, we developed a titanium (Ti)-based material employing a modified alkaline heat treatment that releases strontium (Sr) and silver (Ag) ions (CaSrAg-Ti). In this study, to determine the optimal Ag treatment concentration, we prepared four different materials-commercially pure Ti (cp-Ti) as a negative control, CaSr1mMAg-Ti, CaSr10mMAg-Ti, and CaSr50mMAg-Ti. Ion release test was performed by immersing the prepared disks in fetal bovine serum. With increased loading of Ag ions, the amount of released ions increased. Colony-forming unit count assay was performed using methicillin-susceptible ",
    "authors": [
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Kazuki",
            "initials": "K",
            "lastname": "Orita"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Shunsuke",
            "initials": "S",
            "lastname": "Fujibayashi"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Yaichiro",
            "initials": "Y",
            "lastname": "Okuzu"
        },
        {
            "affiliation": "Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan.",
            "firstname": "Seiji",
            "initials": "S",
            "lastname": "Yamaguchi"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kindai University Hospital, Osaka-Sayama, Japan.",
            "firstname": "Koji",
            "initials": "K",
            "lastname": "Goto"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Bungo",
            "initials": "B",
            "lastname": "Otsuki"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Toshiyuki",
            "initials": "T",
            "lastname": "Kawai"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Takayoshi",
            "initials": "T",
            "lastname": "Shimizu"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Makoto",
            "initials": "M",
            "lastname": "Hayashi"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Norimasa",
            "initials": "N",
            "lastname": "Ikeda"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Yusuke",
            "initials": "Y",
            "lastname": "Takaoka"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Shintaro",
            "initials": "S",
            "lastname": "Honda"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Tatsuhito",
            "initials": "T",
            "lastname": "Ikezaki"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.",
            "firstname": "Shuichi",
            "initials": "S",
            "lastname": "Matsuda"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1177/08853282251329276",
    "journal": "Journal of biomaterials applications",
    "keywords": [
        "Alkaline heat treatment",
        "anti-inflammatory",
        "antibacterial",
        "bone-bonding",
        "silver",
        "strontium",
        "titanium"
    ],
    "methods": null,
    "publication_date": "2025-03-21",
    "pubmed_id": "40112347",
    "results": null,
    "title": "Biocompatibility and antibacterial activity of strontium and silver ion-releasing titanium with high silver treatment concentration.",
    "xml": "<Element 'PubmedArticle' at 0x7885022d9210>"
}