{
    "abstract": "Cardiac resynchronization therapy (CRT) improves the morbidity and mortality rate in patients with left bundle-branch block (LBBB); however, some LBBB patients are non-responders for CRT. Previous studies have shown that a transmural functional line block alters the left ventricular (LV) activation sequence, and that the presence of a line block is predictive for responders. We investigated whether responders could be predicted in patients with LBBB by 2-dimensional (2-D) speckle tracking strain imaging.\nWe enrolled 54 patients with LBBB, who underwent echocardiography before and 6 months after CRT implantation. A responder was defined by a decrease in the LV end-systolic volume\u00a0>15% at the 6-month follow-up. We calculated a difference in the time from QRS onset to maximum strain between adjacent segments and defined the Tmax-diff as the maximum difference among six intersegments. We compared the Tmax-diff between responders and non-responders.\nAmong 54 patients, 37 patients were identified as responders. The Tmax-diff of the responders was significantly longer than that of the non-responders (309.6 \u00b1 168.6\u00a0ms vs 181.5 \u00b1 138.4\u00a0ms, P\u00a0=\u00a0.009). Furthermore, Tmax-diff \u2265 195\u00a0ms was higher in the septal and the anterior area. And patients with a Tmax-diff \u2265 195\u00a0ms tended to be responders (P\u00a0=\u00a0.02).\nThe present study showed that discontinuous contraction of the LV could be detected in CRT responders by 2-D speckle tracking strain imaging, which may be a useful tool to identify the contraction pattern of patients with LBBB and predict CRT responders.",
    "authors": [
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Aya",
            "initials": "A",
            "lastname": "Fujii"
        },
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Yasuya",
            "initials": "Y",
            "lastname": "Inden"
        },
        {
            "affiliation": "Department of Advanced Cardiovascular Therapeutics, Nagoya, Japan.",
            "firstname": "Satoshi",
            "initials": "S",
            "lastname": "Yanagisawa"
        },
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Keita",
            "initials": "K",
            "lastname": "Mamiya"
        },
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Hiroya",
            "initials": "H",
            "lastname": "Okamoto"
        },
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Yusuke",
            "initials": "Y",
            "lastname": "Sakamoto"
        },
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Toshiro",
            "initials": "T",
            "lastname": "Tomomatsu"
        },
        {
            "affiliation": "Department of Advanced Cardiovascular Therapeutics, Nagoya, Japan.",
            "firstname": "Rei",
            "initials": "R",
            "lastname": "Shibata"
        },
        {
            "affiliation": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.",
            "firstname": "Toyoaki",
            "initials": "T",
            "lastname": "Murohara"
        }
    ],
    "conclusions": "The present study showed that discontinuous contraction of the LV could be detected in CRT responders by 2-D speckle tracking strain imaging, which may be a useful tool to identify the contraction pattern of patients with LBBB and predict CRT responders.",
    "copyrights": "\u00a9 2019 Wiley Periodicals, Inc.",
    "doi": "10.1111/pace.13759",
    "journal": "Pacing and clinical electrophysiology : PACE",
    "keywords": [
        "2-D speckle tracking strain imaging",
        "cardiac resynchronization therapy",
        "heart failure",
        "left bundle-branch block",
        "responder"
    ],
    "methods": null,
    "publication_date": "2019-07-20",
    "pubmed_id": "31321796",
    "results": "Among 54 patients, 37 patients were identified as responders. The Tmax-diff of the responders was significantly longer than that of the non-responders (309.6 \u00b1 168.6\u00a0ms vs 181.5 \u00b1 138.4\u00a0ms, P\u00a0=\u00a0.009). Furthermore, Tmax-diff \u2265 195\u00a0ms was higher in the septal and the anterior area. And patients with a Tmax-diff \u2265 195\u00a0ms tended to be responders (P\u00a0=\u00a0.02).",
    "title": "Discontinuous contraction in the left ventricle assessed by 2-D speckle tracking echocardiography benefits from CRT.",
    "xml": "<Element 'PubmedArticle' at 0x788505df9d00>"
}