{
    "abstract": "Patients with cerebral venous thrombosis (CVT) may present with early intracerebral hemorrhage (EICH). The objective of this study was to identify predictors for EICH in CVT patients via a systematic review and meta-analysis of observational studies. Additionally, we aimed to evaluate the clinical outcomes associated with the presence of EICH in these patients.\nLiterature search on PubMed, EMBASE and Cochrane Library databases from inception up to 1 February 2024 was conducted. Five studies with predictors of EICH were included in qualitative synthesis and meta-analysis.\nPooled analysis demonstrated a statistically significant association between female gender and EICH (odd ratios (OR) = 1.51, 95 % confidence interval (CI) = 1.23-1.85, p < 0.01). The ICH patients had higher likelihood of seizures (OR = 3.07, 95 % CI = 1.69-5.58, p < 0.01), focal neurological deficits (OR = 4.07, 95 % CI = 2.57-6.44, p < 0.01), and decreased level of consciousness (OR = 3.89, 95 % CI = 2.53-5.87, p < 0.01). Superior Sagittal Sinus thrombosis was associated with higher likelihood of EICH (OR: 1.49, 95 % CI 1.05-2.13, P = 0.03). No statistically significant association was demonstrated between presence of EICH and pregnancy, presence of hematological diseases or thrombophilia, or other site of venous thrombosis (deep venous system, or multiple sinuses involvement). Furthermore, patients who exhibited early EICH were notably less likely to attain a favorable functional outcome (mRS 0-2) (OR: 0.28; 95 % CI 0.16-0.49; p < 0.001).\nThis meta-analysis demonstrates that among CVT patients, female patients with new onset seizures, focal neurological deficits and decreased level of consciousness are more likely to present with EICH.",
    "authors": [
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA; Promedica Stroke Network, Toledo, OH, USA. Electronic address: Khaled.gharaibeh@utoledo.edu.",
            "firstname": "Khaled",
            "initials": "K",
            "lastname": "Gharaibeh"
        },
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA.",
            "firstname": "Nameer",
            "initials": "N",
            "lastname": "Aladamat"
        },
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA.",
            "firstname": "Aizaz",
            "initials": "A",
            "lastname": "Ali"
        },
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA; Promedica Stroke Network, Toledo, OH, USA.",
            "firstname": "Adam T",
            "initials": "AT",
            "lastname": "Mierzwa"
        },
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA.",
            "firstname": "Hira",
            "initials": "H",
            "lastname": "Pervez"
        },
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA; Promedica Stroke Network, Toledo, OH, USA.",
            "firstname": "Mouhammad",
            "initials": "M",
            "lastname": "Jumaa"
        },
        {
            "affiliation": "Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH, USA; Promedica Stroke Network, Toledo, OH, USA.",
            "firstname": "Syed",
            "initials": "S",
            "lastname": "Zaidi"
        }
    ],
    "conclusions": "This meta-analysis demonstrates that among CVT patients, female patients with new onset seizures, focal neurological deficits and decreased level of consciousness are more likely to present with EICH.",
    "copyrights": "Copyright \u00a9 2024 The Author(s). Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.jstrokecerebrovasdis.2024.108028",
    "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association",
    "keywords": [
        "Cerebral Sinus Venous Thrombosis (CSVT)",
        "Early Intracerebral Hemorrhage",
        "Predictors"
    ],
    "methods": null,
    "publication_date": "2024-09-30",
    "pubmed_id": "39343153",
    "results": "Pooled analysis demonstrated a statistically significant association between female gender and EICH (odd ratios (OR) = 1.51, 95 % confidence interval (CI) = 1.23-1.85, p < 0.01). The ICH patients had higher likelihood of seizures (OR = 3.07, 95 % CI = 1.69-5.58, p < 0.01), focal neurological deficits (OR = 4.07, 95 % CI = 2.57-6.44, p < 0.01), and decreased level of consciousness (OR = 3.89, 95 % CI = 2.53-5.87, p < 0.01). Superior Sagittal Sinus thrombosis was associated with higher likelihood of EICH (OR: 1.49, 95 % CI 1.05-2.13, P = 0.03). No statistically significant association was demonstrated between presence of EICH and pregnancy, presence of hematological diseases or thrombophilia, or other site of venous thrombosis (deep venous system, or multiple sinuses involvement). Furthermore, patients who exhibited early EICH were notably less likely to attain a favorable functional outcome (mRS 0-2) (OR: 0.28; 95 % CI 0.16-0.49; p < 0.001).",
    "title": "Predictors of early intracerebral hemorrhage in patients with cerebral sinus venous thrombosis: Systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788506e67100>"
}