{
    "abstract": "We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia\u00a0(PPE), or\u00a0hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc\u00a0moderately differentiated proximal rectal adenocarcinoma who was undergoing neoadjuvant chemotherapy. Given its severe impact on the quality of life, HFS often requires independent local anti-inflammatory treatment\u00a0and subsequent dose delay and/or modification of the patient's chemotherapy. We believe that our findings in this report can aid clinicians in the early recognition and management of capecitabine-associated HFS resulting in balanitis, as prompt treatment may reduce morbidity and avoid prolonged interruption of chemotherapy in these patients.",
    "authors": [
        {
            "affiliation": "Internal Medicine, Huntington Hospital, Los Angeles, USA.",
            "firstname": "Bryan L",
            "initials": "BL",
            "lastname": "Chan"
        },
        {
            "affiliation": "Oncology, Huntington Hospital, Los Angeles, USA.",
            "firstname": "Tina",
            "initials": "T",
            "lastname": "Wang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024, Chan et al.",
    "doi": "10.7759/cureus.57570",
    "journal": "Cureus",
    "keywords": [
        "balanitis",
        "capecitabine-induced",
        "hand-foot syndrome",
        "palmar-plantar erythrodysesthesia",
        "topical tacrolimus"
    ],
    "methods": null,
    "publication_date": "2024-05-06",
    "pubmed_id": "38707169\n23552007\n24795111\n35590388\n17311704\n17685874\n15342618\n17350337\n25341548\n30788193\n24615748",
    "results": null,
    "title": "Capecitabine-Induced Genital Hand-Foot Syndrome Treated With Topical Tacrolimus.",
    "xml": "<Element 'PubmedArticle' at 0x78850407f1a0>"
}