{
    "abstract": "Resistance of cancer cells, especially breast cancer, to therapeutic medicines represents a major clinical obstacle that impedes the stages of treatment. Carcinoma cells that acquire resistance to therapeutic drugs can reprogram their own metabolic processes as a way to overcome the effectiveness of treatment and continue their reproduction processes. Despite the recent developments in medical research in the field of drug resistance, which showed some explanations for this phenomenon, the real explanation, along with the ability to precisely predict the possibility of its occurrence in breast cancer cells, still necessitates a deep consideration of the dynamics of the tumor's response to treatment. For this purpose the current study, combined both ",
    "authors": [
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Mai O",
            "initials": "MO",
            "lastname": "Kadry"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Gamal Eldein Fathy",
            "initials": "GEF",
            "lastname": "Abd-Ellatef"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Naglaa M",
            "initials": "NM",
            "lastname": "Ammar"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Heba A",
            "initials": "HA",
            "lastname": "Hassan"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Noha S",
            "initials": "NS",
            "lastname": "Hussein"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Nahla N",
            "initials": "NN",
            "lastname": "Kamel"
        },
        {
            "affiliation": "National Research Center, Biology Unit, Central Laboratory for Pharmaceutical and drug industries Research Institute, Chemistry of Medicinal Plants Department, Al Bohouth Street, Dokki, Egypt.",
            "firstname": "Maha M",
            "initials": "MM",
            "lastname": "Soltan"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Rehab M",
            "initials": "RM",
            "lastname": "Abdel-Megeed"
        },
        {
            "affiliation": "National Research Center, Therapeutic Chemistry Department,\u00a0Al Bohouth Street,\u00a0Egypt.",
            "firstname": "Abdel-Hamid Z",
            "initials": "AZ",
            "lastname": "Abdel-Hamid"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Authors.",
    "doi": "10.1016/j.toxrep.2024.101884\n10.1016/j.phrs.2021.105975\n10.3389/fonc.2022.820173\n10.14218/GE.2023.00069\n10.3389/fnut.2020.603370\n10.1186/s12967-020-02313-z\n10.1002/cam4.3732\n10.1186/s12943-024-02119-3\n10.1038/s41523-022-00468-0",
    "journal": "Toxicology reports",
    "keywords": [
        "ABCA1",
        "Breast cancer",
        "EGFR",
        "Metabolomics",
        "PTEN"
    ],
    "methods": null,
    "publication_date": "2025-01-31",
    "pubmed_id": "39886047\n34785319\n38827789\n38639647\n38474312\n31323288\n36360213\n27795708\n28336372\n29466297\n31370818\n33790792\n30996079\n35178349\n31006103\n33339398\n27896521\n32676170\n16778565\n16168107\n30867161\n30876460\n29777275\n24647592\n30553982\n18789882\n22628656\n32775300\n35952450\n28266762\n36301384\n33777987\n28972559\n29252036\n36831661\n27035231\n36078127\n38347517\n31819192\n20479934\n35954330\n33325755\n37944067\n17882277\n34624510\n33606974\n32449848\n18771580\n36810\n32272953\n33620160\n27480155\n26771115\n28208702\n12917336\n32016825\n32698395\n35954376\n22621751\n25584894\n31019378\n36633525\n27063568\n30366412\n37457134\n39294640\n35582007\n31859349\n29162448\n33019814\n35987766\n28219713\n32982287\n33953682",
    "results": null,
    "title": "Metabolomics integrated genomics approach: Understanding multidrug resistance phenotype in MCF-7 breast cancer cells exposed to doxorubicin and ABCA1/EGFR/PI3k/PTEN crosstalk.",
    "xml": "<Element 'PubmedArticle' at 0x788502b193f0>"
}