{
    "abstract": "This study aimed to evaluate the early effects of N-acetylcysteine, which has antioxidant, inflame-modulatory, and cytoprotective properties, on tendon healing.\nThirty-five male Wistar Hannover rats were divided into five groups: first-week treatment (Group 1T), first-week control (Group 1C), third-week treatment (Group 3T), third-week control (Group 3C), and native tendons (Group N). Bilateral Achilles tenotomy was performed on all rats except Group N. After tenotomy, 150\u2009mg/kg N-acetylcysteine was administered daily intraperitoneally to treatment groups, while isotonic saline was given to the control groups. Tendons were evaluated histopathologically, immunohistochemically, and biomechanically after sacrifice in the first and third weeks.\nNo significant differences were observed in the first week (\nN-acetylcysteine supplied some improved results on early markers of tendon healing. Although our findings support the potential of NAC as a therapeutic adjunct in tendon injuries, further studies are needed to evaluate the long-term effects and underlying mechanisms.",
    "authors": [
        {
            "affiliation": "Istanbul Kanuni Sultan S\u00fcleyman Training and Research Hospital, Department of Orthopaedics and Traumatology, Health Sciences University, Istanbul, Turkey.",
            "firstname": "Halil",
            "initials": "H",
            "lastname": "B\u00fcy\u00fckdo\u011fan"
        },
        {
            "affiliation": "Istanbul Kanuni Sultan S\u00fcleyman Training and Research Hospital, Department of Orthopaedics and Traumatology, Health Sciences University, Istanbul, Turkey.",
            "firstname": "Cemil",
            "initials": "C",
            "lastname": "Ert\u00fcrk"
        },
        {
            "affiliation": "G\u00fclhane Training and Research Hospital, Department of Orthopaedics and Traumatology, Health Sciences University, Ankara, Turkey.",
            "firstname": "Erdal",
            "initials": "E",
            "lastname": "Eren"
        },
        {
            "affiliation": "Department of Pathology, Recep Tayyip Erdo\u011fan University Training and Research Hospital, Rize, Turkey.",
            "firstname": "\u00c7i\u011fdem",
            "initials": "\u00c7",
            "lastname": "\u00d6zt\u00fcrk"
        },
        {
            "affiliation": "K\u0131rklareli Training and Research Hospital, Department of Orthopaedics and Traumatology, K\u0131rklareli, Turkey.",
            "firstname": "Burak",
            "initials": "B",
            "lastname": "Y\u0131ld\u0131r\u0131m"
        },
        {
            "affiliation": "Tuzla State Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.",
            "firstname": "Tahir Burak",
            "initials": "TB",
            "lastname": "Sar\u0131ta\u015f"
        },
        {
            "affiliation": "Department of Mechanical Engineering, Y\u0131ld\u0131z Technical University, Istanbul, Turkey.\nDepartment of Mechanical Engineering, YTU-AMRG (Advanced Materials Research Group), Y\u0131ld\u0131z Technical University, Istanbul, Turkey.",
            "firstname": "Metehan",
            "initials": "M",
            "lastname": "Demirkol"
        }
    ],
    "conclusions": "N-acetylcysteine supplied some improved results on early markers of tendon healing. Although our findings support the potential of NAC as a therapeutic adjunct in tendon injuries, further studies are needed to evaluate the long-term effects and underlying mechanisms.",
    "copyrights": null,
    "doi": "10.1080/03008207.2025.2479501",
    "journal": "Connective tissue research",
    "keywords": [
        "Biomechanics",
        "N-acetylcysteine;\u2009",
        "collagen",
        "immunohistochemistry",
        "tendon healing"
    ],
    "methods": null,
    "publication_date": "2025-03-22",
    "pubmed_id": "40119667",
    "results": "No significant differences were observed in the first week (",
    "title": "The impact of N-acetylcysteine on early periods of tendon healing: ",
    "xml": "<Element 'PubmedArticle' at 0x788504ee0a40>"
}