{
    "abstract": "To investigate the potential anti-hepatitis B virus (HBV) activity of Icariside \u2161 (ICS \u2161), and elucidate its underlying mitochondrial dynamics mechanisms.\nThe study employed \nThe study found that ICS \u2161 exhibited significant anti-HBV effects both \nICS \u2161 exhibits significant anti-HBV potential through its regulation of mitochondrial dynamics and ROS production.",
    "authors": [
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Zhengyun",
            "initials": "Z",
            "lastname": "Liu"
        },
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Haiyan",
            "initials": "H",
            "lastname": "Yang"
        },
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Juan",
            "initials": "J",
            "lastname": "Wen"
        },
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.\nDepartment of Basic Teaching, Zunyi Medical and Pharmaceutical College, Zunyi, Guizhou, China.",
            "firstname": "Dongyan",
            "initials": "D",
            "lastname": "Xiao"
        },
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Wan",
            "initials": "W",
            "lastname": "Yu"
        },
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Guo",
            "initials": "G",
            "lastname": "Luo"
        },
        {
            "affiliation": "Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Qihai",
            "initials": "Q",
            "lastname": "Gong"
        },
        {
            "affiliation": "Key Laboratory of Infectious Disease and Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China.",
            "firstname": "Huan",
            "initials": "H",
            "lastname": "Wang"
        }
    ],
    "conclusions": "ICS \u2161 exhibits significant anti-HBV potential through its regulation of mitochondrial dynamics and ROS production.",
    "copyrights": "Copyright \u00a9 2025 Liu, Yang, Wen, Xiao, Yu, Luo, Gong and Wang.",
    "doi": "10.3389/fphar.2025.1544714\n10.1002/hep.29239\n10.1146/annurev-pathmechdis-012419-032711\n10.3389/fmicb.2017.02425\n10.1111/jcmm.12971\n10.1038/s42003-023-05017-4\n10.3390/ijms25126606\n10.3389/fimmu.2018.02860\n10.1371/journal.ppat.1003722\n10.1016/j.mito.2020.05.005\n10.1016/j.semcdb.2009.12.012\n10.1016/j.coviro.2021.12.010\n10.3389/fimmu.2023.1203645\n10.1016/j.ejphar.2023.175987\n10.3390/antiox11091705\n10.1136/gutjnl-2023-330389\n10.14169/j.cnki.zunyixuebao.2023.0082\n10.1053/j.gastro.2018.06.083\n10.15252/embr.201949019\n10.1021/jf202376u\n10.1371/journal.ppat.1009340\n10.3390/microorganisms10071265\n10.3389/fnins.2021.715945\n10.1016/j.molcel.2023.02.012\n10.1128/jvi.00424-24\n10.1038/s41467-022-29945-7\n10.1091/mbc.12.8.2245\n10.1242/jcs.01058\n10.13359/j.cnki.gzxbtcm.2019.09.028\n10.3389/fcell.2020.00413\n10.1016/j.cmet.2015.06.006\n10.1016/j.freeradbiomed.2024.01.011\n10.1038/cdd.2015.129\n10.1038/s41401-019-0300-2\n10.3969/j.issn.1003-3734.2023.14.012",
    "journal": "Frontiers in pharmacology",
    "keywords": [
        "HepG2.2.15 cell",
        "ROS",
        "hepatitis B virus",
        "icariside II",
        "mitochondrial dynamic",
        "reactive oxygen species"
    ],
    "methods": null,
    "publication_date": "2025-04-16",
    "pubmed_id": "40235545\n28445927\n31585519\n29270164\n27642051\n37400627\n38928309\n30564245\n24339771\n32470613\n20045077\n34973476\n37781396\n37572941\n36139776\n37788894\n30012333\n33180995\n21870867\n33596274\n35888983\n34744606\n36889315\n38629837\n35487893\n11514614\n14996942\n32587855\n26166745\n38215891\n26794444\n31554962",
    "results": "The study found that ICS \u2161 exhibited significant anti-HBV effects both ",
    "title": "Icarisid \u2161 modulates mitochondrial dynamics for anti-HBV activity.",
    "xml": "<Element 'PubmedArticle' at 0x78850680c400>"
}