{
    "abstract": "Ectopic pregnancy (EP) is a life-threatening disease that affects humans and other mammals. Tumors causing ruptures of the reproductive tract have been identified as possible predisposing factors in human and veterinary medicine. We here describe a case of concomitant ectopic pregnancy and lymphoma in a Eurasian red squirrel found deceased in Italy and submitted to the public health laboratory Istituto Zooprofilattico Sperimentale del Lazio e della Toscana (IZSLT) for post-mortem examination. A full-term partially mummified ectopic fetus in the abdomen and a large fibrinonecrotic tubal scar adjacent to the right ovary were observed at necropsy. The tubal scar is likely the point of tubal rupture through which the fetus displaced. Histology revealed the presence of neoplastic cells referable to lymphoma infiltrating the ovary, spleen, small intestine, heart and peripancreatic adipose tissue. The lymphoma was further characterized as T-cell-type using immunohistochemistry. We suggest that the lymphoma, by involving the ovary, played a pathogenetic role in the development of a secondary EP by altering the genital tract at the structural and hormonal levels. To the best of our knowledge, this is the first report of concomitant ovarian lymphoma and EP in animals and humans in the literature.",
    "authors": [
        {
            "affiliation": "Istituto Zooprofilattico Sperimentale del Lazio e Della Toscana \"M. Aleandri\", 02100 Rieti, Italy.",
            "firstname": "Caterina",
            "initials": "C",
            "lastname": "Raso"
        },
        {
            "affiliation": "Istituto Zooprofilattico Sperimentale del Lazio e Della Toscana \"M. Aleandri\", 00178 Roma, Italy.",
            "firstname": "Valentina",
            "initials": "V",
            "lastname": "Galietta"
        },
        {
            "affiliation": "Istituto Zooprofilattico Sperimentale del Lazio e Della Toscana \"M. Aleandri\", 00178 Roma, Italy.",
            "firstname": "Claudia",
            "initials": "C",
            "lastname": "Eleni"
        },
        {
            "affiliation": "UOC Igiene e Sanit\u00e0 Animale, ASL Rieti, 02100 Rieti, Italy.",
            "firstname": "Marco",
            "initials": "M",
            "lastname": "Innocenti"
        },
        {
            "affiliation": "Dipartimento di Scienze Veterinarie, Universit\u00e0 di Pisa, Viale delle Piagge, 56124 Pisa, Italy.",
            "firstname": "Niccol\u00f2",
            "initials": "N",
            "lastname": "Fonti"
        },
        {
            "affiliation": "Istituto Zooprofilattico Sperimentale del Lazio e Della Toscana \"M. Aleandri\", 00178 Roma, Italy.",
            "firstname": "Tiziana",
            "initials": "T",
            "lastname": "Palmerini"
        },
        {
            "affiliation": "UOC Igiene e Sanit\u00e0 Animale, ASL Rieti, 02100 Rieti, Italy.",
            "firstname": "Mauro",
            "initials": "M",
            "lastname": "Grillo"
        },
        {
            "affiliation": "Istituto Zooprofilattico Sperimentale del Lazio e Della Toscana \"M. Aleandri\", 02100 Rieti, Italy.",
            "firstname": "Pietro",
            "initials": "P",
            "lastname": "Calderini"
        },
        {
            "affiliation": "Istituto Zooprofilattico Sperimentale del Lazio e Della Toscana \"M. Aleandri\", 02100 Rieti, Italy.",
            "firstname": "Elena",
            "initials": "E",
            "lastname": "Borgogni"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ani14050731\n10.4404/hystrix-19.1-4418\n10.1644/07-MAMM-A-064R2.1\n10.1016/j.theriogenology.2016.04.041\n10.3390/ani10040738\n10.1530/rep.1.00606\n10.5326/JAAHA-MS-5732\n10.1016/j.theriogenology.2003.11.005\n10.1016/j.jfms.2011.04.003\n10.1080/00480169.2013.800443\n10.1258/002367781780953022\n10.1530/jrf.0.0560679\n10.1186/1746-6148-9-229\n10.3354/dao03014\n10.3389/fvets.2019.00254\n10.1016/j.fertnstert.2009.03.039\n10.1097/01.AOG.0000462567.43599.73\n10.1046/j.1440-1827.2001.01183.x\n10.1016/j.ygyno.2020.01.027\n10.1016/j.etp.2006.01.007\n10.1038/s41568-018-0004-9\n10.1038/s41568-018-0045-0\n10.1136/vr.c4196\n10.1638/06-055.1\n10.1097/00013644-200409000-00005\n10.1177/0192623319867053\n10.1097/00000478-199302000-00007\n10.7759/cureus.40685\n10.1177/10935266231200114\n10.3390/ani11092543\n10.1038/nrc2665",
    "journal": "Animals : an open access journal from MDPI",
    "keywords": [
        "Sciurus vulgaris",
        "T-cell lymphoma",
        "ectopic pregnancy"
    ],
    "methods": null,
    "publication_date": "2024-03-13",
    "pubmed_id": "38473116\n27155730\n32344507\n16595714\n22474049\n15226019\n21641255\n24602549\n23768170\n7341850\n480319\n24238087\n27409239\n31440520\n19393994\n24427372\n11328538\n31983516\n16713211\n29622806\n30116020\n20729517\n17939360\n10403450\n15322388\n31526133\n8422111\n37485204\n37771167\n34573509\n19550426",
    "results": null,
    "title": "Ectopic Pregnancy and T-Cell Lymphoma in a Eurasian Red Squirrel (",
    "xml": "<Element 'PubmedArticle' at 0x7885031f3880>"
}