{
    "abstract": "To investigate the relationship between platelet counts within the first 24 hours of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support and in-hospital mortality in postcardiotomy ECMO patients. Adult patients undergoing postcardiotomy V-A ECMO from 2017 to 2021 were included and divided into survivors and non-survivors. Logistic regression evaluated the association between the first-day platelet counts and in-hospital mortality. Spearman's correlation assessed the correlations between clinical factors and the platelet hourly % decrease within 24 hours of ECMO support. The study included 72 patients, with an in-hospital mortality of 51.4%. For every 10 \u00d7109/L decrease in the lowest platelet count at 0-24, 0-12, and 12-24 hours of ECMO support, the odds of in-hospital mortality increased by 21.7% (adjusted odds ratios [aOR], 1.217; 95% confidence intervals [CI], 1.045-1.358), 20.6% (aOR, 1.206; 95% CI, 1.058-1.332), and 17.4% (aOR, 1.174; 95% CI, 1.034-1.294), respectively. Platelet hourly % decrease was positively correlated with peak lactate, alanine aminotransferase, D-dimer, fibrinogen degradation products, and ECMO flow rate variation. In postcardiotomy V-A ECMO patients, platelet counts within the first 24 hours of ECMO support are independently associated with higher in-hospital mortality. Potential factors related to decreasing rate of platelet count included thrombosis, ECMO flow fluctuation, tissue ischemia, and hypoxia.",
    "authors": [
        {
            "affiliation": "From the Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases.",
            "firstname": "Jing",
            "initials": "J",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Pain Management, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.",
            "firstname": "Sizhe",
            "initials": "S",
            "lastname": "Gao"
        },
        {
            "affiliation": "From the Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases.",
            "firstname": "Tianlong",
            "initials": "T",
            "lastname": "Wang"
        },
        {
            "affiliation": "From the Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases.",
            "firstname": "Han",
            "initials": "H",
            "lastname": "Zhang"
        },
        {
            "affiliation": "From the Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases.",
            "firstname": "Luyu",
            "initials": "L",
            "lastname": "Bian"
        },
        {
            "affiliation": "From the Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases.",
            "firstname": "Shujie",
            "initials": "S",
            "lastname": "Yan"
        },
        {
            "affiliation": "From the Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases.",
            "firstname": "Bingyang",
            "initials": "B",
            "lastname": "Ji"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 ASAIO 2025.",
    "doi": "10.1097/MAT.0000000000002393",
    "journal": "ASAIO journal (American Society for Artificial Internal Organs : 1992)",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-02-13",
    "pubmed_id": "39946641",
    "results": null,
    "title": "First-Day Platelet Count Is Associated With In-Hospital Mortality in Adult Postcardiotomy Extracorporeal Membrane Oxygenation.",
    "xml": "<Element 'PubmedArticle' at 0x788506659c60>"
}