{
    "abstract": "The liver, a complex parenchymal organ, possesses a distinctive microcirculatory system crucial for its physiological functions. An intricate interplay exists between hepatic microcirculatory disturbance and the manifestation of pathological features in diverse liver diseases. This review updates the main characteristics of hepatic microcirculatory disturbance, including hepatic sinusoidal capillarization, narrowing of sinusoidal space, portal hypertension, and pathological angiogenesis, as well as their formation mechanisms. It also summarized the detection methods for hepatic microcirculation. Simultaneously, we have also reviewed the characteristics of microcirculatory disturbance in diverse liver diseases such as acute liver failure, hepatic ischemia-reperfusion injury, viral hepatitis, non-alcoholic fatty liver disease, hepatic fibrosis, hepatic cirrhosis, and hepatocellular carcinoma. Finally, this review also summarizes the advancement in hepatic microcirculation attributed to traditional Chinese medicine (TCM) and its active metabolites, providing novel insights into the application of TCM in treating liver diseases.",
    "authors": [
        {
            "affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.\nGuangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Pei",
            "initials": "P",
            "lastname": "Liu"
        },
        {
            "affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.\nGuangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Wan-Li",
            "initials": "WL",
            "lastname": "Liang"
        },
        {
            "affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.\nGuangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Rui-Ting",
            "initials": "RT",
            "lastname": "Huang"
        },
        {
            "affiliation": "Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Xin-Xing",
            "initials": "XX",
            "lastname": "Chen"
        },
        {
            "affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.\nGuangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "De-Hua",
            "initials": "DH",
            "lastname": "Zou"
        },
        {
            "affiliation": "Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Hiroshi",
            "initials": "H",
            "lastname": "Kurihara"
        },
        {
            "affiliation": "Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Yi-Fang",
            "initials": "YF",
            "lastname": "Li"
        },
        {
            "affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.",
            "firstname": "You-Hua",
            "initials": "YH",
            "lastname": "Xu"
        },
        {
            "affiliation": "Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Shu-Hua",
            "initials": "SH",
            "lastname": "Ouyang"
        },
        {
            "affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.\nGuangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility, Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.",
            "firstname": "Rong-Rong",
            "initials": "RR",
            "lastname": "He"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Liu, Liang, Huang, Chen, Zou, Kurihara, Li, Xu, Ouyang and He.",
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    "journal": "Frontiers in pharmacology",
    "keywords": [
        "active metabolite",
        "hepatic microcirculatory disturbance",
        "liver disease",
        "pathogenesis",
        "traditional Chinese medicine"
    ],
    "methods": null,
    "publication_date": "2024-08-07",
    "pubmed_id": "39108760\n25460199\n38534382\n29368124\n30959975\n35659879\n35931392\n37627562\n25920081\n31885839\n29916772\n31992991\n34387685\n33933107\n27255130\n24890205\n29023881\n33407215\n21849149\n35837401\n30918428\n36731809\n34630075\n31790896\n34830874\n27182154\n33589830\n30568278\n26939970\n32659305\n33177789\n38775498\n28322971\n36900595\n29209117\n36621128\n34857782\n2754546\n11725532\n36653797\n35489326\n36549368\n31198956\n30285464\n21463341\n3300465\n34337369\n37781526\n38690019\n34367949\n34513722\n36296934\n34983093\n25529809\n33745018\n33106666\n25568858\n28317925\n32811746\n32290100\n6313508\n34862369\n26919996\n31183002\n23678853\n38155904\n27776340\n38713020\n33505496\n22929805\n21489701\n31201834\n33730288\n31234023\n30348985\n35685625\n23459859\n34766732\n28187500\n29075990\n38596498\n38460355\n37577237\n37901735\n30218773\n25960048\n24037429\n33346004\n30023233\n31602356\n36010588\n38724938\n34337431\n34426178\n38608209\n29220210\n34821751\n36061155\n22509248\n35967364\n23811302\n35277075\n28628674\n30809090\n33670126\n31597160\n32602249\n32260126\n36208844\n33144522\n25769560\n30980261\n29844586\n35582617\n32734387\n34588998\n32170489\n33763069\n33062150\n24750984\n20800926\n37852110\n29112863\n26203733\n38649221\n23799952\n27756878\n32951003\n34276360\n27293456\n36804628\n25720342\n26086560\n35982187\n31885639\n28857294\n32875781\n30551534\n38663797\n36036898\n35776157\n31250637\n33145353\n28440736\n32595742\n26427787\n24637190",
    "results": null,
    "title": "Hepatic microcirculatory disturbance in liver diseases: intervention with traditional Chinese medicine.",
    "xml": "<Element 'PubmedArticle' at 0x788506779c10>"
}