{
    "abstract": "To present the distribution of neurovascular and lymphatic vessels in uterine ligaments using 3D models based on the pathological staining of serial 2D sections of postoperative specimens.\nSerial transverse sections of fresh uterine ligaments from a patient with stage IB1 cervical squamous cell carcinoma were studied using the computer-assisted anatomic dissection (CAAD) technique. The sections were stained with hematoxylin and eosin, Weigert elastic fibers, D2-40 and immunostainings (sheep anti-tyrosine hydroxylase and rabbit anti-vasoactive intestinal peptide). The sections were then digitalized, registered and reconstructed three-dimensionally. Then, the 3D models were analyzed and measured.\nThe 3D models of the neurovascular and lymphatic vessels in uterine ligaments were created, depicting their precise location and distribution. The vessels were primarily located in the upper part of the ligaments model, while the pelvic autonomic nerves were primarily in the lower part; the lymphatic vessels were scattered in the uterine ligaments, without obvious regularity.\nCAAD is an effective anatomical method to study the precise distribution of neurovascular and lymphatic vessels in uterine ligaments. It can present detailed anatomical information about female pelvic autonomic innervation and the spatial relationship between nerves and vessels and may provide a better understanding of nerve-sparing radical hysterectomy.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.",
            "firstname": "Pengfei",
            "initials": "P",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.",
            "firstname": "Hui",
            "initials": "H",
            "lastname": "Duan"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.",
            "firstname": "Jun",
            "initials": "J",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.",
            "firstname": "Shipeng",
            "initials": "S",
            "lastname": "Gong"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.",
            "firstname": "Guidong",
            "initials": "G",
            "lastname": "Su"
        },
        {
            "affiliation": "Department of Anatomy, Guangdong Province Key Laboratory of Medical Biomechanics, School of Basic Medicine Science, Southern Medical University, Guangzhou, China.",
            "firstname": "Jianyi",
            "initials": "J",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Anatomy, Guangdong Province Key Laboratory of Medical Biomechanics, School of Basic Medicine Science, Southern Medical University, Guangzhou, China.",
            "firstname": "Lei",
            "initials": "L",
            "lastname": "Tang"
        },
        {
            "affiliation": "Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.",
            "firstname": "Yan",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.",
            "firstname": "Huijian",
            "initials": "H",
            "lastname": "Fan"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China. lpivy@126.com.",
            "firstname": "Ping",
            "initials": "P",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China. ccl1@smu.edu.cn.",
            "firstname": "Chunlin",
            "initials": "C",
            "lastname": "Chen"
        }
    ],
    "conclusions": "CAAD is an effective anatomical method to study the precise distribution of neurovascular and lymphatic vessels in uterine ligaments. It can present detailed anatomical information about female pelvic autonomic innervation and the spatial relationship between nerves and vessels and may provide a better understanding of nerve-sparing radical hysterectomy.",
    "copyrights": null,
    "doi": "10.1007/s00404-019-05108-w",
    "journal": "Archives of gynecology and obstetrics",
    "keywords": [
        "3D reconstruction",
        "Cervical cancer",
        "Histological examination",
        "Nerve-sparing",
        "Pelvic autonomic nerves"
    ],
    "methods": null,
    "publication_date": "2019-03-16",
    "pubmed_id": "30874947",
    "results": "The 3D models of the neurovascular and lymphatic vessels in uterine ligaments were created, depicting their precise location and distribution. The vessels were primarily located in the upper part of the ligaments model, while the pelvic autonomic nerves were primarily in the lower part; the lymphatic vessels were scattered in the uterine ligaments, without obvious regularity.",
    "title": "Neurovascular and lymphatic vessels distribution in uterine ligaments based on a 3D reconstruction of histological study: to determine the optimal plane for nerve-sparing radical hysterectomy.",
    "xml": "<Element 'PubmedArticle' at 0x7885033df560>"
}