{
    "abstract": "The integrity of the DNA is continously menaced by the harmful genotoxic compounds. The endogenous system responsible for preserving the DNA integrity, often fails following a massive influx of these genotoxic compounds. Reseaches on exogenous bioactive compounds from fruits and vegetables are necessary. This study was designed to evaluate the free radical scavenging activity and the DNA protection/repair potentiality of the extracts of \nThe ability of extracts to trap free radicals was assessed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide and hydroxyle radicals quenching assay. The comet assay was performed for evaluating the DNA protection/repair property of extracts to inhibit the DNA oxidative damage induced by arsenic trioxide.\nAll extracts at a final concentration of 50 \u00b5g/mL have quenched more than 50% of DPPH, nitric oxide and hydroxyle radicals. Moreover, all extracts have showed good DNA protection/repair activity against the arsenic trioxide-induced DNA oxidative damage compared to arsenic treatment alone (p<0.001). However, methanol fractions have exhibited the best DNA protection/repair activities by reducing considerably DNA fragmentations compared to arsenic treatment (p<0.001). The genoprotective activity of the extracts was positively correlated with their free radical scavenging abilities.\nThe methanol fraction of ",
    "authors": [
        {
            "affiliation": "Laboratoire de Biochimie et Chimie Appliqu\u00e9es (LABIOCA), UFR-SVT, Universit\u00e9 Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso.",
            "firstname": "Ablass\u00e9",
            "initials": "A",
            "lastname": "Rouamba"
        },
        {
            "affiliation": "Laboratoire de Biochimie et Chimie Appliqu\u00e9es (LABIOCA), UFR-SVT, Universit\u00e9 Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso.",
            "firstname": "Vincent",
            "initials": "V",
            "lastname": "Ouedraogo"
        },
        {
            "affiliation": "Laboratoire de Physiologie Animale (LAPA), UFR-SVT, Universit\u00e9 Joseph KI-ZERBO, 09 BP 848, Ouagadougou 09, Burkina Faso.",
            "firstname": "Maurice",
            "initials": "M",
            "lastname": "Ou\u00e9draogo"
        },
        {
            "affiliation": "Laboratoire de Biochimie et Chimie Appliqu\u00e9es (LABIOCA), UFR-SVT, Universit\u00e9 Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso.",
            "firstname": "Martin",
            "initials": "M",
            "lastname": "Kiendrebeogo"
        }
    ],
    "conclusions": "The methanol fraction of ",
    "copyrights": null,
    "doi": "10.22038/AJP.2024.24842",
    "journal": "Avicenna journal of phytomedicine",
    "keywords": [
        "Arsenic trioxide",
        "DNA repair",
        "Detarium microcarpum",
        "Phytomolecules"
    ],
    "methods": null,
    "publication_date": "2025-04-24",
    "pubmed_id": "40271503\n31239861\n33922139\n35209118\n22628047\n31585675\n30037082\n28485537\n32866568\n23583964\n24637991\n32164186\n28340065\n33330091\n18463567\n27527154\n29731617\n26404387\n34458433\n30081554\n35889433\n20623008\n33573222\n27447602",
    "results": "All extracts at a final concentration of 50 \u00b5g/mL have quenched more than 50% of DPPH, nitric oxide and hydroxyle radicals. Moreover, all extracts have showed good DNA protection/repair activity against the arsenic trioxide-induced DNA oxidative damage compared to arsenic treatment alone (p<0.001). However, methanol fractions have exhibited the best DNA protection/repair activities by reducing considerably DNA fragmentations compared to arsenic treatment (p<0.001). The genoprotective activity of the extracts was positively correlated with their free radical scavenging abilities.",
    "title": "Antioxidant effects and protective potential of fruit extracts of ",
    "xml": "<Element 'PubmedArticle' at 0x788504d77010>"
}