{
    "abstract": "Taurine, an amino-sulfonic acid mainly sourced from food, suppresses blood glucose by stimulating insulin secretion from pancreatic \u03b2-cells. However, its relationship with glucagon-like peptide-1 (GLP-1) secretion from enteroendocrine L cells is unclear. This study aimed to determine the role of taurine in GLP-1 secretion from L cells. Taurine administration promoted GLP-1 secretion in enteroendocrine L cell line GLUTag cells and increased plasma GLP-1 in mice. Taurine uptake via the taurine transporter increased cytosolic ATP levels, resulting in higher intracellular Ca",
    "authors": [
        {
            "affiliation": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.",
            "firstname": "Yuri",
            "initials": "Y",
            "lastname": "Osuga"
        },
        {
            "affiliation": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.\nHealth and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba, Japan.",
            "firstname": "Kazuki",
            "initials": "K",
            "lastname": "Harada"
        },
        {
            "affiliation": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.",
            "firstname": "Takuya",
            "initials": "T",
            "lastname": "Yamauchi"
        },
        {
            "affiliation": "Laboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan.",
            "firstname": "Tetsuya",
            "initials": "T",
            "lastname": "Kitaguchi"
        },
        {
            "affiliation": "RIKEN Center for Sustainable Resource Science, Yokohama, Japan.",
            "firstname": "Masami Yokota",
            "initials": "MY",
            "lastname": "Hirai"
        },
        {
            "affiliation": "Dairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., Tokyo, Japan.",
            "firstname": "Mitsuharu",
            "initials": "M",
            "lastname": "Matsumoto"
        },
        {
            "affiliation": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.",
            "firstname": "Takashi",
            "initials": "T",
            "lastname": "Tsuboi"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.",
    "doi": "10.1002/1873-3468.70014",
    "journal": "FEBS letters",
    "keywords": [
        "GLUTag",
        "glucagon\u2010like peptide\u20101",
        "live\u2010cell imaging",
        "taurine",
        "taurine transporter"
    ],
    "methods": null,
    "publication_date": "2025-03-03",
    "pubmed_id": "40026256",
    "results": null,
    "title": "Taurine promotes glucagon-like peptide-1 secretion in enteroendocrine L cells.",
    "xml": "<Element 'PubmedArticle' at 0x7885046e8090>"
}