{
    "abstract": "To observe the effect of \"Zhibian\" (BL54)-toward-\"Shuidao\" (ST28) needling technique on the relative protein expression of the signaling pathway of nucleotide-binding oligomerization domain-containing protein 1 (NOD1)/ receptor-interacting protein 2 (RIP2)/nuclear factor kappa-B (NF-\u03baB) and the expression of proinflammatory cytokines in the rats with primary dysmenorrhea (PD), so as to explore the underlying mechanism of this acupuncture technique for pain alleviation in PD.\nThirty female SD rats of SPF grade with normal estrous cycle were randomized into a blank group, a model group and an acupuncture group, 10 rats in each one. Using the intraperitoneal injection with estradiol benzoate combined with oxytocin, PD model was prepared in the model group and the acupuncture group. In the acupuncture group, during model preparation, the intervention with \"Zhibian\" (BL54)-toward-\"Shuidao\" (ST28) needling technique was delivered simultaneously, 20 min each time, once daily for consecutive 10 days. On day 11, within 30 min after the intraperitoneal injection with oxytocin, the writhing reaction (latency, frequency and score) was recorded; the morphology of uterine tissue was observed with HE staining, the contents of prostaglandin E\nCompared with the blank group, in the model group, the writhing latency was prolonged (\n\"Zhibian\" (BL54)-toward-\"Shuidao\" (ST28) needling technique can alleviate the pain symptom of PD rats, and its action mechanism may be related to inhibiting the active expression of NOD1/RIP2/NF-\u03baB signaling pathway in the uterine tissue, thereby reducing the inflammatory response.",
    "authors": [
        {
            "affiliation": "Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.",
            "firstname": "Xu",
            "initials": "X",
            "lastname": "Jin"
        },
        {
            "affiliation": "School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM.",
            "firstname": "Yanlin",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.",
            "firstname": "Boya",
            "initials": "B",
            "lastname": "Chang"
        },
        {
            "affiliation": "Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.",
            "firstname": "Jia",
            "initials": "J",
            "lastname": "Ren"
        },
        {
            "affiliation": "Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.",
            "firstname": "Jianheng",
            "initials": "J",
            "lastname": "Hao"
        },
        {
            "affiliation": "Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.",
            "firstname": "Yuxia",
            "initials": "Y",
            "lastname": "Cao"
        },
        {
            "affiliation": "Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.",
            "firstname": "Haijun",
            "initials": "H",
            "lastname": "Wang"
        },
        {
            "affiliation": "Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.",
            "firstname": "Laixi",
            "initials": "L",
            "lastname": "Ji"
        }
    ],
    "conclusions": "\"Zhibian\" (BL54)-toward-\"Shuidao\" (ST28) needling technique can alleviate the pain symptom of PD rats, and its action mechanism may be related to inhibiting the active expression of NOD1/RIP2/NF-\u03baB signaling pathway in the uterine tissue, thereby reducing the inflammatory response.",
    "copyrights": null,
    "doi": "10.13703/j.0255-2930.20240331-k0001",
    "journal": "Zhongguo zhen jiu = Chinese acupuncture & moxibustion",
    "keywords": [
        "NOD1/RIP2/NF-\u03baB signaling pathway",
        "Zhibian (BL54)-toward-Shuidao (ST28)",
        "acupuncture",
        "inflammatory response",
        "pain",
        "primary dysmenorrhea"
    ],
    "methods": null,
    "publication_date": "2025-02-13",
    "pubmed_id": "39943763",
    "results": "Compared with the blank group, in the model group, the writhing latency was prolonged (",
    "title": "[Analgesic effect of \"Zhibian\" (BL54)-toward-\"Shuidao\" (ST28) needling technique of acupuncture on primary dysmenorrhea based on NOD1/RIP2/NF-\u03baB signaling pathway in the rats].",
    "xml": "<Element 'PubmedArticle' at 0x788504409cb0>"
}