{
    "abstract": "The role of excessive inspiratory effort in promoting alveolar and pleural rupture resulting in air leak (AL) in patients with SARS-CoV-2 induced acute respiratory failure (ARF) while on spontaneous breathing is undetermined.\nAmong all patients with COVID-19 related ARF admitted to a respiratory intensive care unit (RICU) and receiving non-invasive respiratory support, those developing an AL were and matched 1:1 [by means of PaO2/FiO2 ratio, age, body mass index-BMI and subsequent organ failure assessment (SOFA)] with a comparable population who did not (NAL group). Esophageal pressure (\u0394P\nAir leak and NAL groups (\nIn spontaneously breathing patients with COVID-19 related ARF, higher levels of \u0394P",
    "authors": [
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.\nClinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Roberto",
            "initials": "R",
            "lastname": "Tonelli"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Giulia",
            "initials": "G",
            "lastname": "Bruzzi"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Linda",
            "initials": "L",
            "lastname": "Manicardi"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Luca",
            "initials": "L",
            "lastname": "Tabb\u00ec"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Riccardo",
            "initials": "R",
            "lastname": "Fantini"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.\nClinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Ivana",
            "initials": "I",
            "lastname": "Castaniere"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.\nClinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Dario",
            "initials": "D",
            "lastname": "Andrisani"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.\nClinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Filippo",
            "initials": "F",
            "lastname": "Gozzi"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Maria Rosaria",
            "initials": "MR",
            "lastname": "Pellegrino"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Fabiana",
            "initials": "F",
            "lastname": "Trentacosti"
        },
        {
            "affiliation": "Intensive Care Unit, University Hospital of Modena, Modena, Italy.",
            "firstname": "Lorenzo",
            "initials": "L",
            "lastname": "Dall'Ara"
        },
        {
            "affiliation": "Intensive Care Unit, University Hospital of Modena, Modena, Italy.",
            "firstname": "Stefano",
            "initials": "S",
            "lastname": "Busani"
        },
        {
            "affiliation": "Infectious Diseases Unit, University Hospital of Modena, Modena, Italy.",
            "firstname": "Erica",
            "initials": "E",
            "lastname": "Franceschini"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Serena",
            "initials": "S",
            "lastname": "Baroncini"
        },
        {
            "affiliation": "Department of Surgery, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Gianrocco",
            "initials": "G",
            "lastname": "Manco"
        },
        {
            "affiliation": "Infectious Diseases Unit, University Hospital of Modena, Modena, Italy.",
            "firstname": "Marianna",
            "initials": "M",
            "lastname": "Meschiari"
        },
        {
            "affiliation": "Infectious Diseases Unit, University Hospital of Modena, Modena, Italy.",
            "firstname": "Cristina",
            "initials": "C",
            "lastname": "Mussini"
        },
        {
            "affiliation": "Intensive Care Unit, University Hospital of Modena, Modena, Italy.",
            "firstname": "Massimo",
            "initials": "M",
            "lastname": "Girardis"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Bianca",
            "initials": "B",
            "lastname": "Begh\u00e8"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Alessandro",
            "initials": "A",
            "lastname": "Marchioni"
        },
        {
            "affiliation": "Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy.",
            "firstname": "Enrico",
            "initials": "E",
            "lastname": "Clini"
        }
    ],
    "conclusions": "In spontaneously breathing patients with COVID-19 related ARF, higher levels of \u0394P",
    "copyrights": "Copyright \u00a9 2022 Tonelli, Bruzzi, Manicardi, Tabb\u00ec, Fantini, Castaniere, Andrisani, Gozzi, Pellegrino, Trentacosti, Dall\u2019Ara, Busani, Franceschini, Baroncini, Manco, Meschiari, Mussini, Girardis, Begh\u00e8, Marchioni and Clini.",
    "doi": "10.3389/fmed.2022.848639\n10.3390/jcm10050975\n10.1183/13993003.02697-2020\n10.1183/23120541.00385-2020\n10.1136/bcr-2020-239489\n10.7759/cureus.11749\n10.1136/bcr-2020-235861\n10.1164/rccm.202008-3376IM\n10.1016/j.rmed.2021.106464\n10.1056/NEJM200005043421801\n10.1007/s00134-004-2187-7\n10.7759/cureus.8996\n10.4269/ajtmh.20-0815\n10.1155/2020/4969486\n10.1148/radiol.2020202352\n10.4329/wjr.v6.i11.850\n10.1164/rccm.202105-1179IM\n10.1186/s13613-021-00904-7\n10.1016/j.cmi.2020.12.011\n10.1164/rccm.201912-2512OC\n10.7759/cureus.3639\n10.1097/MCC.0b013e32834f17d9\n10.1016/j.jiph.2020.05.012\n10.1164/rccm.202104-1029LE\n10.1186/s13613-021-00967-6\n10.1126/science.368.6490.455\n10.1186/s40560-015-0083-6\n10.1007/s00134-021-06519-7\n10.1007/s00134-020-06033-2\n10.1186/s13027-021-00369-0\n10.1016/S2213-2600(20)30370-2\n10.23736/S0375-9393.20.15002-8\n10.3390/jcm10214835\n10.21037/jtd-20-1363\n10.1016/j.thromres.2021.04.012",
    "journal": "Frontiers in medicine",
    "keywords": [
        "COVID-19",
        "acute respiratory failure",
        "esophageal manometry",
        "inspiratory effort",
        "non-invasive mechanical ventilation",
        "pneumomediastinum",
        "pneumothorax",
        "pulmonary air leak"
    ],
    "methods": null,
    "publication_date": "2022-04-19",
    "pubmed_id": "35433732\n33801368\n32907891\n33257914\n33310838\n33403179\n32423911\n33448891\n34044224\n10793162\n14991090\n32642391\n32705978\n33123202\n32614258\n25431639\n34403328\n34255207\n33359375\n32325004\n30740281\n22157254\n32475804\n34214009\n34928455\n32355007\n27408729\n34529118\n32291463\n34001199\n32861276\n33325217\n34768352\n33145063\n33894421",
    "results": "Air leak and NAL groups (",
    "title": "Risk Factors for Pulmonary Air Leak and Clinical Prognosis in Patients With COVID-19 Related Acute Respiratory Failure: A Retrospective Matched Control Study.",
    "xml": "<Element 'PubmedArticle' at 0x788503c4a110>"
}