{
    "abstract": "The study aimed to compare the effectiveness and side effects of 600 \u03bcg of oral Misoprostol with 10 international units (IU) intramuscular oxytocin in managing the third stage of labor.\nThis open-label, randomized controlled trial included 260 low-risk women in the second stage of labor with anticipated vaginal delivery. They were randomly assigned, to receive either 600 \u03bcg of misoprostol orally or 10 IU of oxytocin intramuscularly. The primary outcomes were blood loss during delivery and incidence of postpartum hemorrhage, evaluated using intention-to-treat analysis. Significance was set at P\u22640.05.\nBaseline characteristics were similar in both groups (P>0.05). The misoprostol group had a significantly lower blood loss than that of the oxytocin group (306.57\u00b1176.44 mL vs. 349.37\u00b1135.50 mL; relative difference, -12.251 [95% confidence intervals [CI], -22.528 to -1.575]; P=0.012). Incidence of postpartum hemorrhage was similar in both the groups (relative risk [RR], 0.952 [95% CI, 0.543 to 0.671]; P=0.865). Additional oxytocic therapy requirement was also comparable (RR, 1.143 [95% CI, 0.671 to 1.947]; P=0.623). Nausea, shivering, and mean increase in temperature were significantly more common in the misoprostol group than in the oxytocin-parturient group.\nIn this study, 600 \u03bcg oral misoprostol was superior to intramuscular 10 IU oxytocin in reducing blood loss at birth, and equally effective in preventing postpartum hemorrhage. However, misoprostol exhibited more side effects compared to that of oxytocin.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Federal Medical Centre, Bida, Niger State, Nigeria.",
            "firstname": "Atanda Abdulrasaq",
            "initials": "AA",
            "lastname": "Sambo"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Ilorin Teaching Hospital, University of Ilorin, Ilorin, Nigeria.",
            "firstname": "Munir'deen Aderemi",
            "initials": "MA",
            "lastname": "Ijaiya"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Maitama District Hospital, Federal Capital Territory Administration, Abuja, Nigeria.",
            "firstname": "Duum",
            "initials": "D",
            "lastname": "Nwachukwu"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Federal Medical Centre, Bida, Niger State, Nigeria.",
            "firstname": "Ikemefuna Christopher",
            "initials": "IC",
            "lastname": "Nwosu"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Federal Medical Centre, Bida, Niger State, Nigeria.",
            "firstname": "Haruna",
            "initials": "H",
            "lastname": "Idris"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Federal Medical Centre, Bida, Niger State, Nigeria.",
            "firstname": "Rasheedat Morayo",
            "initials": "RM",
            "lastname": "Abdullateef"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Federal Medical Centre, Bida, Niger State, Nigeria.",
            "firstname": "Folorunsho Benard",
            "initials": "FB",
            "lastname": "Adewale"
        }
    ],
    "conclusions": "In this study, 600 \u03bcg oral misoprostol was superior to intramuscular 10 IU oxytocin in reducing blood loss at birth, and equally effective in preventing postpartum hemorrhage. However, misoprostol exhibited more side effects compared to that of oxytocin.",
    "copyrights": null,
    "doi": "10.5468/ogs.23128",
    "journal": "Obstetrics & gynecology science",
    "keywords": [
        "Misoprostol",
        "Nigeria",
        "Oxytocin",
        "Postpartum haemorrhage"
    ],
    "methods": null,
    "publication_date": "2024-02-27",
    "pubmed_id": "38409787\n35297039\n36575559\n31164260\n24641530\n31139461\n25835642\n24049221\n25128176\n36741612\n27006180\n32649710\n12452458",
    "results": "Baseline characteristics were similar in both groups (P>0.05). The misoprostol group had a significantly lower blood loss than that of the oxytocin group (306.57\u00b1176.44 mL vs. 349.37\u00b1135.50 mL; relative difference, -12.251 [95% confidence intervals [CI], -22.528 to -1.575]; P=0.012). Incidence of postpartum hemorrhage was similar in both the groups (relative risk [RR], 0.952 [95% CI, 0.543 to 0.671]; P=0.865). Additional oxytocic therapy requirement was also comparable (RR, 1.143 [95% CI, 0.671 to 1.947]; P=0.623). Nausea, shivering, and mean increase in temperature were significantly more common in the misoprostol group than in the oxytocin-parturient group.",
    "title": "A randomized controlled study comparing oral misoprostol with intramuscular oxytocin in active management of third stage of labour.",
    "xml": "<Element 'PubmedArticle' at 0x788504bb9350>"
}