{
    "abstract": "An unexpected impaired ovarian response pertains to an insufficient reaction to controlled ovarian hyperstimulation. This deficient reaction is identified by a reduced count of mature follicles and retrieved oocytes during an IVF cycle, potentially diminishing the likelihood of a successful pregnancy. This research seeks to examine whether the characteristics of antral follicles can serve as predictive indicators for the unexpected impaired ovarian response to controlled ovarian stimulation (COS).\nThis retrospective cohort study was conducted at a tertiary university hospital. The electronic database of the ART (assisted reproductive technologies) center was screened between the years 2012-2022. Infertile women under 35 years, with normal ovarian reserve [anti-M\u00fcllerian hormone (AMH)\u2009>\u20091.2 ng/ml, antral follicle count (AFC)\u2009>\u20095] who underwent their first controlled ovarian stimulation (COS) cycle were selected. Women with <\u20099 oocytes retrieved (group 1 of the Poseidon classification) constituted the group A, whereas those with \u2265\u20099 oocytes severed as control (normo-responders) one (group B). Demographic, anthropometric and hormonal variables together with COS parameters of the two groups were compared.\nThe number of patients with <\u20099 oocytes (group A) was 404, and those with \u2265\u20099 oocytes were 602 (group B). The mean age of the group A was significantly higher (30.1\u2009+\u20092.9 vs. 29.4\u2009+\u20092.9, p\u2009=\u20090.01). Group A displayed lower AMH and AFC [with interquartile ranges (IQR); AMH 1.6 ng/ml (1-2.6) vs. 3.5 ng/ml (2.2-5.4) p\u2009<\u20090.01, AFC 8 (6-12) vs. 12 (9-17), p\u2009<\u20090.01]. The number of small antral follicles (2-5\u00a0mm) of the group A was significantly lower [6 (4-8) vs. 8 (6-12) p\u2009<\u20090.01), while the larger follicles (5-10\u00a0mm) remained similar [3 (1-5) vs. 3(1-6) p\u2009=\u20090.3] between the groups.\nThe propensity of low ovarian reserve and higher age are the main risk factors for the impaired ovarian response. The proportion of the small antral follicles may be a predictive factor for ovarian response to prevent unexpected poor results.",
    "authors": [
        {
            "affiliation": "Faculty of Medicine, Dept. of Obstetrics and Gynecology, Bursa Uludag University, Bursa, Turkey. guncu@gurkanuncu.org.",
            "firstname": "G\u00fcrkan",
            "initials": "G",
            "lastname": "Uncu"
        },
        {
            "affiliation": "Faculty of Medicine, Dept. of Obstetrics and Gynecology, Bursa Uludag University, Bursa, Turkey.",
            "firstname": "Kiper",
            "initials": "K",
            "lastname": "Aslan"
        },
        {
            "affiliation": "Faculty of Medicine, Dept of Histology and Embryology, Bursa Uludag University, Bursa, Turkey.",
            "firstname": "Cihan",
            "initials": "C",
            "lastname": "Cakir"
        },
        {
            "affiliation": "Faculty of Medicine, Dept of Histology and Embryology, Bursa Uludag University, Bursa, Turkey.",
            "firstname": "Berrin",
            "initials": "B",
            "lastname": "Avci"
        },
        {
            "affiliation": "Faculty of Medicine, Dept. of Obstetrics and Gynecology, Bursa Uludag University, Bursa, Turkey.",
            "firstname": "Isil",
            "initials": "I",
            "lastname": "Kasapoglu"
        },
        {
            "affiliation": "Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.",
            "firstname": "Carlo",
            "initials": "C",
            "lastname": "Alviggi"
        }
    ],
    "conclusions": "The propensity of low ovarian reserve and higher age are the main risk factors for the impaired ovarian response. The proportion of the small antral follicles may be a predictive factor for ovarian response to prevent unexpected poor results.",
    "copyrights": "\u00a9 2023. The Author(s).",
    "doi": "10.1186/s13048-023-01323-x\n10.3389/fendo.2018.00361\n10.1093/humrep/dev149\n10.1093/humrep/der092\n10.1016/j.fertnstert.2016.02.005\n10.12688/f1000research.10382.1\n10.3389/fendo.2021.630550\n10.1016/j.rbmo.2020.07.011\n10.1016/j.rbms.2019.08.003\n10.1093/humrep/deq361\n10.3389/fendo.2018.00589\n10.1016/j.fertnstert.2009.04.040\n10.1016/j.ebiom.2022.104084\n10.1186/1757-2215-7-67\n10.1093/humupd/dmy019\n10.1093/humrep/deab068\n10.1093/humrep/deh625\n10.1016/j.fertnstert.2016.03.002\n10.1016/S0015-0282(03)00741-6\n10.1093/humrep/dey217\n10.1093/oxfordjournals.humrep.a137570\n10.1016/S0015-0282(99)00396-9\n10.1093/humrep/dem081\n10.1080/01443615.2021.1910640\n10.1080/01443615.2021.2003309\n10.1093/molehr/gah015\n10.1093/hropen/hoab022",
    "journal": "Journal of ovarian research",
    "keywords": [
        "Anti-mullerian hormone",
        "Antral Follicle",
        "Ovarian Reserve",
        "Poor ovarian response",
        "Poseidon"
    ],
    "methods": null,
    "publication_date": "2024-01-04",
    "pubmed_id": "38169411\n26724797\n30083131\n26202582\n21505041\n26921622\n28232864\n33790862\n32843305\n31993512\n10999835\n21177311\n30386293\n19589513\n35660784\n24991235\n29924306\n33889959\n15576390\n27020168\n12969701\n32754681\n29912374\n1291557\n10560988\n17437960\n34155958\n34996328\n14742691\n34250273",
    "results": "The number of patients with <\u20099 oocytes (group A) was 404, and those with \u2265\u20099 oocytes were 602 (group B). The mean age of the group A was significantly higher (30.1\u2009+\u20092.9 vs. 29.4\u2009+\u20092.9, p\u2009=\u20090.01). Group A displayed lower AMH and AFC [with interquartile ranges (IQR); AMH 1.6 ng/ml (1-2.6) vs. 3.5 ng/ml (2.2-5.4) p\u2009<\u20090.01, AFC 8 (6-12) vs. 12 (9-17), p\u2009<\u20090.01]. The number of small antral follicles (2-5\u00a0mm) of the group A was significantly lower [6 (4-8) vs. 8 (6-12) p\u2009<\u20090.01), while the larger follicles (5-10\u00a0mm) remained similar [3 (1-5) vs. 3(1-6) p\u2009=\u20090.3] between the groups.",
    "title": "Do we overlook predictive factors in Poseidon 1 patients? A retrospective analysis co-evaluating antral follicle counts & diameters.",
    "xml": "<Element 'PubmedArticle' at 0x788506411300>"
}