{
    "abstract": "Hypertension is a significant risk factor in heart failure for worldwide patients. More than half of hypertensive patients suffer from heart failure. Recently, sacubitril/valsartan (sac/val) has been approved as an antihypertensive agent in China and Japan. Additionally, it is not approved for treating hypertension in Europe or the USA.\nTo accumulate more real-world experiences to investigate the effectiveness and optimize clinical medication of sac/val in hypertensive patients with heart failure.\nWe retrospectively enrolled adult patients diagnosed with hypertension (HTN) and heart failure (HF) and newly treated with sac/val. The baseline characteristics and clinical outcomes were retrospectively extracted from electronic medical records (EMR) in three centers. The efficacy and safety of sac/val were first analyzed in all enrolled patients. Stratified analyses were conducted in patients with different ages (\u2265\u200965, < 65), maximum tolerated doses (\u2265\u2009200\u00a0mg/days, < 200\u00a0mg/days), and renal functions (e-GFR\u2009\u2265\u200960 ml/min/1.73 m\nOverall, 794 patients diagnosed with both HF and HTN were included in our study. During follow-up, significant reductions were found in blood pressure (BP) (SBP 12.8\u2009\u00b1\u200921.2 mmHg, P\u2009<\u20090.001, DBP 7.1\u2009\u00b1\u200916.5 mmHg, P\u2009<\u20090.001), and cardiac biomarkers (cardiac troponin 1.78\u2009\u00b1\u200919.1 ng/mL, P\u2009<\u20090.001, NT-proBNP 1403\u2009\u00b1\u20096937 pg/mL, P\u2009<\u20090.001) from baseline. In stratification analyses, the lower dosage group earned a higher BP control rate (83.4% vs. 75.6%, P\u2009=\u20090.025) and an overall improvement rate of cardiac indicators (61.3% vs. 48.0%, P\u2009=\u20090.002). The younger patients' group had significantly less cumulative hazard of recurrent cerebral-cardiovascular events than the elder group (log-rank P value\u2009<\u20090.001). Patients with renal dysfunction were observed with more AE incidences.\nSac/val could reduce BP and improve cardiac structural and functional parameters in hypertensive patients with HF, even with less than target doses. However, more attention should be paid to older patients and renal dysfunction patients when using sac/val because of additional risks in adverse events.",
    "authors": [
        {
            "affiliation": "Department of Pharmacy, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.",
            "firstname": "Yingyun",
            "initials": "Y",
            "lastname": "Guan"
        },
        {
            "affiliation": "Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.",
            "firstname": "Xiaoye",
            "initials": "X",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Pharmacy, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.",
            "firstname": "Hui",
            "initials": "H",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Pharmacy, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201799, China.",
            "firstname": "Jinmei",
            "initials": "J",
            "lastname": "Ren"
        },
        {
            "affiliation": "Department of Pharmacy, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201799, China.",
            "firstname": "Kouming",
            "initials": "K",
            "lastname": "Tang"
        },
        {
            "affiliation": "Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.",
            "firstname": "Chi",
            "initials": "C",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.",
            "firstname": "Zhichun",
            "initials": "Z",
            "lastname": "Gu"
        },
        {
            "affiliation": "Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. li.xiaoyu@zs-hospital.sh.cn.",
            "firstname": "Xiaoyu",
            "initials": "X",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. 13916088938@163.com.",
            "firstname": "Qianzhou",
            "initials": "Q",
            "lastname": "Lv"
        },
        {
            "affiliation": "Department of Pharmacy, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China. bxl70029@hotmail.com.",
            "firstname": "Xiaolan",
            "initials": "X",
            "lastname": "Bian"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023. Italian Society of Hypertension.",
    "doi": "10.1007/s40292-023-00606-0\n10.1097/01.hjh.0000199801.72563.6f\n10.1111/jch.13437\n10.1038/hr.2014.169\n10.3760/cma.j.issn.1671-7368.2019.04.002\n10.3969/j.issn.1000-3614.2015.05.002\n10.1093/ehjcvp/pvv031\n10.1002/prp2.794\n10.1016/j.ijcard.2021.01.061\n10.1016/S0140-6736(09)61966-8\n10.1161/HYPERTENSIONAHA.113.02002\n10.1097/HJH.0000000000002453\n10.1097/HJH.0000000000003480\n10.1016/j.jacc.2019.09.063\n10.3390/jcm12020699\n10.1002/ehf2.12974\n10.3390/jcm10132824\n10.1007/s11886-018-0944-4\n10.1007/s40119-021-00252-4\n10.1161/CIRCHEARTFAILURE.117.004745\n10.1002/ejhf.580\n10.4330/wjc.v4.i5.135\n10.3390/healthcare10050895\n10.1016/j.ijcard.2022.09.050\n10.1007/s40266-022-00951-0\n10.1093/eurheartj/eht386\n10.1007/s11739-019-02111-6\n10.1056/NEJMoa1409077\n10.1161/CIRCHEARTFAILURE.111.961573\n10.1016/j.jchf.2013.11.007",
    "journal": "High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-11-18",
    "pubmed_id": "37979031\n16467639\n30536595\n25503845\n27532450\n34087050\n33545266\n20236700\n24446062\n32371787\n31806129\n36675628\n32977362\n34206864\n29374807\n35094306\n29643067\n27283779\n22655162\n36174825\n35701577\n24164864\n31147823\n25176015\n21705485\n24720923",
    "results": "Overall, 794 patients diagnosed with both HF and HTN were included in our study. During follow-up, significant reductions were found in blood pressure (BP) (SBP 12.8\u2009\u00b1\u200921.2 mmHg, P\u2009<\u20090.001, DBP 7.1\u2009\u00b1\u200916.5 mmHg, P\u2009<\u20090.001), and cardiac biomarkers (cardiac troponin 1.78\u2009\u00b1\u200919.1 ng/mL, P\u2009<\u20090.001, NT-proBNP 1403\u2009\u00b1\u20096937 pg/mL, P\u2009<\u20090.001) from baseline. In stratification analyses, the lower dosage group earned a higher BP control rate (83.4% vs. 75.6%, P\u2009=\u20090.025) and an overall improvement rate of cardiac indicators (61.3% vs. 48.0%, P\u2009=\u20090.002). The younger patients' group had significantly less cumulative hazard of recurrent cerebral-cardiovascular events than the elder group (log-rank P value\u2009<\u20090.001). Patients with renal dysfunction were observed with more AE incidences.",
    "title": "Sacubitril/Valsartan in Heart Failure with Hypertension Patients: Real-World Experiences on Different Ages, Drug Doses, and Renal Functions.",
    "xml": "<Element 'PubmedArticle' at 0x7885030a59e0>"
}