{
    "abstract": "The necessity of increasing the efficiency of organ preservation has encouraged researchers to explore the mechanisms underlying diabetes-related myocardial injuries. This study intended to evaluate the protective effects of oxymatrine (OMT) in myocardial injury caused by type 2 diabetes mellitus. A model of diabetic rats was established to simulate type 2 diabetes mellitus using an intraperitoneal injection of a single dose of 65\u2009mg/kg streptozotocin with a high-fat and high-cholesterol diet, and diabetic rats were subsequently treated with OMT (60, 120\u2009mg/kg) by gavage for 8\u2009weeks. Thereafter, diabetic rats demonstrated notable decreases in left ventricular systolic pressure (LVSP), \u00b1dp/dt",
    "authors": [
        {
            "affiliation": "Medicine School, Changsha Social Work College, Changsha, 410004, Hunan, China.",
            "firstname": "Yongpan",
            "initials": "Y",
            "lastname": "Huang"
        },
        {
            "affiliation": "School of Nursing, Hunan University of Medicine, Huaihua, 418000, China.",
            "firstname": "Bin",
            "initials": "B",
            "lastname": "He"
        },
        {
            "affiliation": "Medicine School, Changsha Social Work College, Changsha, 410004, Hunan, China.",
            "firstname": "Chong",
            "initials": "C",
            "lastname": "Song"
        },
        {
            "affiliation": "Medicine School, Changsha Social Work College, Changsha, 410004, Hunan, China.",
            "firstname": "Xian",
            "initials": "X",
            "lastname": "Long"
        },
        {
            "affiliation": "Department of Respiratory and Critical Care Medicine, The First People's Hospital of Huaihua, affiliated to University of South China, Huaihua, 418000, Hunan, China. hjb0919hh@163.com.",
            "firstname": "Jianbin",
            "initials": "J",
            "lastname": "He"
        },
        {
            "affiliation": "Medicine School, Changsha Social Work College, Changsha, 410004, Hunan, China.",
            "firstname": "Yansong",
            "initials": "Y",
            "lastname": "Huang"
        },
        {
            "affiliation": "Medicine School, Changsha Social Work College, Changsha, 410004, Hunan, China. liulijingcsmz@163.com.",
            "firstname": "Lijing",
            "initials": "L",
            "lastname": "Liu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2022. The Author(s).",
    "doi": "10.1186/s12906-022-03818-4\n10.1161/CIRCRESAHA.118.314665\n10.1007/s00125-017-4390-4\n10.1161/CIRCRESAHA.119.316288\n10.1016/j.redox.2020.101493\n10.1016/j.phymed.2021.153546\n10.1111/jcmm.14870\n10.3390/ijms21186902\n10.3892/ijmm.2016.2680\n10.1155/2020/3732718\n10.1177/2058738418781634\n10.3390/cancers11010049\n10.1155/2020/3912173\n10.1016/j.phrs.2019.104541\n10.1016/j.taap.2020.115209\n10.3389/fphar.2019.00715\n10.1002/jcb.28006\n10.1016/j.freeradbiomed.2014.12.010\n10.1111/j.1476-5381.2012.01911.x\n10.1155/2018/5047526\n10.12659/MSM.908529\n10.1002/jbt.22747\n10.1080/21655979.2021.1995994\n10.1590/S0102-865020150060000008\n10.1006/meth.2001.1262\n10.1155/2017/6437467\n10.1080/21655979.2021.1974760\n10.1016/j.pharmthera.2008.08.002\n10.1016/j.ijcard.2018.04.082\n10.1016/j.yjmcc.2015.12.020\n10.3390/antiox9080679\n10.1155/2018/8296451\n10.1152/physrev.00003.2016\n10.1016/j.phrs.2015.09.014\n10.3389/fphys.2018.00114\n10.1016/j.biopha.2018.11.064\n10.1155/2019/7067619\n10.1016/j.biopha.2018.07.126\n10.1080/13880209.2020.1779318\n10.1016/j.apsb.2020.12.020\n10.3389/fcell.2021.696542\n10.2147/DMSO.S211700\n10.3389/fcell.2021.696542\n10.3389/fphar.2021.660757\n10.1111/jcmm.13674\n10.1186/s12935-021-02085-6",
    "journal": "BMC complementary medicine and therapies",
    "keywords": [
        "Apoptosis",
        "Diabetes",
        "Inflammation",
        "Myocardial injury",
        "Oxidative stress",
        "Oxymatrine"
    ],
    "methods": null,
    "publication_date": "2023-01-04",
    "pubmed_id": "36597092\n30973809\n28776083\n32084643\n32134364\n32182574\n33799221\n31856386\n32962281\n27430285\n33062139\n30103640\n30621055\n33273999\n31733326\n32835761\n31417401\n30456880\n25530150\n22352879\n29850605\n30161099\n33624406\n34699317\n26108031\n11846609\n28298952\n34516361\n18786563\n30047409\n26718721\n32751309\n29541348\n27604527\n26432957\n29515457\n30551471\n31781345\n29675132\n30099338\n32649845\n34589395\n34327204\n31695460\n34327204\n33935784\n29799160\n30809743\n34284780",
    "results": null,
    "title": "Oxymatrine ameliorates myocardial injury by inhibiting oxidative stress and apoptosis via the Nrf2/HO-1 and JAK/STAT pathways in type 2 diabetic rats.",
    "xml": "<Element 'PubmedArticle' at 0x78850667ed40>"
}