{
    "abstract": "Aim: to investigate the epidemiology, microbiology, and risk factors for healthcare-associated infections (HAIs) in postoperative patients with intracranial aneurysm in Ukraine.\nMaterials and Methods: Retrospective cohort study was conducted from January 2018 to December 2022 in four tertiary care hospitals of Ukraine. The diagnostic criteria were based on specific HAI site were adapted from the CDC/NHSN case definitions.\nResults: Of 1,084 postoperative patients with intracranial aneurysm, 128 (11.4%) HAIs were observed. The most common of HAI type was possible ventilatorassociated pneumonia (38.2%) followed by central line-associated bloodstream infections (33.8%), catheter -associated urinary tract infection (18.5%), and surgical site infection (9.6%). Inpatient mortality from HAI was 5.1%. Emergency admission, mechanical ventilation, taking antiplatelet aggregation drugs, albumin reduction, hyperglycaemia, hyponatremia, surgical procedure, operation time > 4 h, mechanical ventilation, urinary catheter, and central venous catheterization were risk factors associated with HAI in patients with intracranial aneurysm surgery. A total of 26% cases of HAIs by MDROs were notified over the study period. Klebsiella spp. - essentially K. pneumoniae - were the most frequent, followed by Enterobacter spp. and Escherichia coli. Carbapenemase production in Enterobacterales constituted the most frequent mechanism of resistance, while ESBL-production in Enterobacterales and meticillin-resistance in Staphylococcus aureus (MRSA) were detected in 65,7% 62,3% and 20% of cases, respectively.\nConclusions: The present study showed that HAIs is a common complication in postoperative patients with intracranial aneurysm in Ukraine and multidrugresistant organisms the major pathogen causing infection.",
    "authors": [
        {
            "affiliation": "SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE, SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Aidyn G",
            "initials": "AG",
            "lastname": "Salmanov"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Dmytro V",
            "initials": "DV",
            "lastname": "Shchehlov"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.",
            "firstname": "Maryna",
            "initials": "M",
            "lastname": "Mamonova"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Oleh E",
            "initials": "OE",
            "lastname": "Svyrydiuk"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Ihor M",
            "initials": "IM",
            "lastname": "Bortnik"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Nadiia B",
            "initials": "NB",
            "lastname": "Chabanovych"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Yaroslav E",
            "initials": "YE",
            "lastname": "Kudelskyi"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Oleksandr P",
            "initials": "OP",
            "lastname": "Kovalenko"
        },
        {
            "affiliation": "SCIENTIFIC-PRACTICAL CENTER OF ENDOVASCULAR NEURORADIOLOGY AND SURGERY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Daria",
            "initials": "D",
            "lastname": "Chekhunova"
        }
    ],
    "conclusions": "Conclusions: The present study showed that HAIs is a common complication in postoperative patients with intracranial aneurysm in Ukraine and multidrugresistant organisms the major pathogen causing infection.",
    "copyrights": null,
    "doi": "10.36740/Merkur202402101",
    "journal": "Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego",
    "keywords": [
        "Ukraine",
        "intracranial aneurysm",
        "pathogens",
        "antimicrobial resistance",
        "healthcare-associated infection",
        "neurosurgery",
        "risk factor"
    ],
    "methods": null,
    "publication_date": "2024-04-20",
    "pubmed_id": "38642348",
    "results": "Results: Of 1,084 postoperative patients with intracranial aneurysm, 128 (11.4%) HAIs were observed. The most common of HAI type was possible ventilatorassociated pneumonia (38.2%) followed by central line-associated bloodstream infections (33.8%), catheter -associated urinary tract infection (18.5%), and surgical site infection (9.6%). Inpatient mortality from HAI was 5.1%. Emergency admission, mechanical ventilation, taking antiplatelet aggregation drugs, albumin reduction, hyperglycaemia, hyponatremia, surgical procedure, operation time > 4 h, mechanical ventilation, urinary catheter, and central venous catheterization were risk factors associated with HAI in patients with intracranial aneurysm surgery. A total of 26% cases of HAIs by MDROs were notified over the study period. Klebsiella spp. - essentially K. pneumoniae - were the most frequent, followed by Enterobacter spp. and Escherichia coli. Carbapenemase production in Enterobacterales constituted the most frequent mechanism of resistance, while ESBL-production in Enterobacterales and meticillin-resistance in Staphylococcus aureus (MRSA) were detected in 65,7% 62,3% and 20% of cases, respectively.",
    "title": "Healthcare-associated infections in postoperative patients with intracranial aneurysm in Ukraine.",
    "xml": "<Element 'PubmedArticle' at 0x7885021c9f80>"
}