{
    "abstract": "Polycystic ovary syndrome (PCOS) represents major endocrine and metabolic disorder among women largely characterized by hyperandrogenism and oligomenorrhea precipitates serious complications such as type 2 diabetes, early atherosclerosis, infertility, and endometrial cancer. Several etiological theories were proposed to define the exact cause of the PCOS, which is characterized, by the hypothalamic-pituitary axis, ovarian morphology, and release of adrenal steroid hormones, metabolic syndrome, and hereditary factors. The review explored the role of dysbiosis and the mechanisms through which microbial dysbiosis can affect PCOS development. In recent time, various research groups highlighted the role of microbial gut dysbiosis associated with obesity as potential etiological factor for the PCOS. In the present review, we reviewed the mechanisms attributed to the microbial dysbiosis and treatment approaches to deal with the situation.",
    "authors": [
        {
            "affiliation": "Research Scholar, Department of Pharmacology, Gujarat Technological University, Ahmedabad, Gujarat, India; Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.",
            "firstname": "Nisha H",
            "initials": "NH",
            "lastname": "Khobragade"
        },
        {
            "affiliation": "Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India. Electronic address: devang.sheth@lmcp.ac.in.",
            "firstname": "Devang B",
            "initials": "DB",
            "lastname": "Sheth"
        },
        {
            "affiliation": "Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.",
            "firstname": "Chirag A",
            "initials": "CA",
            "lastname": "Patel"
        },
        {
            "affiliation": "Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.",
            "firstname": "Jayesh V",
            "initials": "JV",
            "lastname": "Beladiya"
        },
        {
            "affiliation": "Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.",
            "firstname": "Sandip",
            "initials": "S",
            "lastname": "Patel"
        },
        {
            "affiliation": "Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.",
            "firstname": "Mittal",
            "initials": "M",
            "lastname": "Dalal"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.steroids.2024.109455",
    "journal": "Steroids",
    "keywords": [
        "Microbial dysbiosis",
        "Pathogenesis of PCOS and gut dysbiosis",
        "Polycystic ovary syndrome",
        "Prevalence\u2019s rate",
        "Treatment"
    ],
    "methods": null,
    "publication_date": "2024-06-15",
    "pubmed_id": "38876407",
    "results": null,
    "title": "Polycystic ovary syndrome: Insights into its prevalence, diagnosis, and management with special reference to gut microbial dysbiosis.",
    "xml": "<Element 'PubmedArticle' at 0x788502f0f8d0>"
}