{
    "abstract": "Peripheral lymph nodes (PLN) are critical for immunologic memory formation in response to antigens that penetrate the skin. Blood-borne lymphocytes first encounter such antigens after they home to PLN through a multi-step adhesion process that is normally initiated by L-selectin (CD62L) in high endothelial venules (HEV). Since naive T cells can not enter PLN normally in L-selectin-deficient mice, a delayed type hypersensitivity response to cutaneously applied antigen cannot be mounted. In this study, we report that the administration of activated platelets into the systemic circulation of L-selectin knockout mice restores lymphocyte trafficking to PLN, and reconstitutes T cell-mediated immunity in response to a cutaneous antigen. These effects required platelet-expressed P-selectin that allows activated platelets to transiently form a bridge between lymphocytes and HEV, thereby enabling lymphocytes to undergo subsequent beta2 integrin-dependent firm adhesion. These profound effects of platelet-mediated cell-cell interactions on lymphocyte trafficking and formation of immunologic memory may impact on a variety of autoimmune and inflammatory conditions.",
    "authors": [
        {
            "affiliation": "The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA.",
            "firstname": "T G",
            "initials": "TG",
            "lastname": "Diacovo"
        },
        {
            "affiliation": null,
            "firstname": "M D",
            "initials": "MD",
            "lastname": "Catalina"
        },
        {
            "affiliation": null,
            "firstname": "M H",
            "initials": "MH",
            "lastname": "Siegelman"
        },
        {
            "affiliation": null,
            "firstname": "U H",
            "initials": "UH",
            "lastname": "von Andrian"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1084/jem.187.2.197",
    "journal": "The Journal of experimental medicine",
    "keywords": [],
    "methods": null,
    "publication_date": "1998-02-07",
    "pubmed_id": "9432977\n8600538\n6866086\n1712790\n2040648\n8930886\n9432978\n8976188\n7534203\n7539045\n8662511\n8083366\n7537667\n3518835\n7508438\n7518434\n8986819\n8879206\n7690799\n8617886\n7522321\n8704169\n7513201\n8985251\n8143990\n8256856\n8816432\n3298655\n1910492\n1803514\n9165226\n1688666\n1710840\n1371416\n7526025",
    "results": null,
    "title": "Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice.",
    "xml": "<Element 'PubmedArticle' at 0x7885038f0270>"
}