{
    "abstract": "This nationwide cohort study provides a comprehensive overview of maternal and perinatal outcomes associated with sickle cell disease (SCD) during pregnancy. Using the French national health database, all singleton pregnancy-related hospital discharges from 2013 to 2020 in women aged 15-55 (n\u2009=\u20095\u2009752\u2009080) were selected. Of these, 1022 births were to women with SCD, 308 of whom were on long-term treatment, that is, hydroxyurea (HU) and/or transfusion programme. Pregnancies with SCD were more likely to involve pre-eclampsia (9.6% vs. 1.7%; p\u2009<\u20090.001), pulmonary embolism (0.70% vs. 0.02%; p\u2009<\u20090.001), caesarean sections (52.8% vs. 18.2%; p\u2009<\u20090.001) and postpartum haemorrhage (8.3% vs. 4.1%; p\u2009<\u20090.001) compared to pregnancies without SCD. Preterm birth (<37\u2009weeks) was much more common in women with SCD (28.5% vs. 5.6%). Infants born to women with SCD faced greater adverse neonatal outcomes (22.4% vs. 8.0%; p\u2009<\u20090.001). Although untreated SCD was linked to fewer complications than long-term treated SCD, both conditions presented greater risks compared with pregnancies without SCD. Unexpectedly, babies born to women with SCD had a higher incidence of congenital abnormalities (6.3% vs. 3.4%; p\u2009<\u20090.001), not attributed to HU use. Overall, despite advances in SCD management, pregnancy in SCD remains a high-risk condition, for both mothers and babies.",
    "authors": [
        {
            "affiliation": "Biotherapy Department and Clinical Investigation Center, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France.\nCentre de r\u00e9f\u00e9rence des syndromes dr\u00e9panocytaires majeurs, service de Bioth\u00e9rapie, H\u00f4pital Universitaire Necker-Enfants Malades, Universit\u00e9 de Paris, Paris, France.\nIMAGINE Institute, Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, Paris, France.",
            "firstname": "Alice",
            "initials": "A",
            "lastname": "Corsia"
        },
        {
            "affiliation": "Biotherapy Department and Clinical Investigation Center, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France.\nCentre de r\u00e9f\u00e9rence des syndromes dr\u00e9panocytaires majeurs, service de Bioth\u00e9rapie, H\u00f4pital Universitaire Necker-Enfants Malades, Universit\u00e9 de Paris, Paris, France.",
            "firstname": "Laure",
            "initials": "L",
            "lastname": "Joseph"
        },
        {
            "affiliation": "EA7323, Evaluation th\u00e9rapeutique et pharmacologie p\u00e9rinatale et p\u00e9diatrique, Universit\u00e9 Paris Cit\u00e9, Paris, France.\nUnit\u00e9 de Recherche clinique, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Paris, France.",
            "firstname": "Nathanael",
            "initials": "N",
            "lastname": "Beeker"
        },
        {
            "affiliation": "Biotherapy Department and Clinical Investigation Center, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France.\nCentre de r\u00e9f\u00e9rence des syndromes dr\u00e9panocytaires majeurs, service de Bioth\u00e9rapie, H\u00f4pital Universitaire Necker-Enfants Malades, Universit\u00e9 de Paris, Paris, France.",
            "firstname": "Sandra",
            "initials": "S",
            "lastname": "Manceau"
        },
        {
            "affiliation": "Service de Gyn\u00e9cologie Obst\u00e9trique, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France.",
            "firstname": "Marine",
            "initials": "M",
            "lastname": "Driessen"
        },
        {
            "affiliation": "Biotherapy Department and Clinical Investigation Center, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France.\nCentre de r\u00e9f\u00e9rence des syndromes dr\u00e9panocytaires majeurs, service de Bioth\u00e9rapie, H\u00f4pital Universitaire Necker-Enfants Malades, Universit\u00e9 de Paris, Paris, France.",
            "firstname": "Benoit",
            "initials": "B",
            "lastname": "Meunier"
        },
        {
            "affiliation": "Biotherapy Department and Clinical Investigation Center, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France.\nIMAGINE Institute, Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, Paris, France.",
            "firstname": "Marina",
            "initials": "M",
            "lastname": "Cavazzana"
        },
        {
            "affiliation": "EA7323, Evaluation th\u00e9rapeutique et pharmacologie p\u00e9rinatale et p\u00e9diatrique, Universit\u00e9 Paris Cit\u00e9, Paris, France.\nUnit\u00e9 de Recherche clinique, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Paris, France.",
            "firstname": "Mathis",
            "initials": "M",
            "lastname": "Collier"
        },
        {
            "affiliation": "EA7323, Evaluation th\u00e9rapeutique et pharmacologie p\u00e9rinatale et p\u00e9diatrique, Universit\u00e9 Paris Cit\u00e9, Paris, France.\nUnit\u00e9 de Recherche clinique, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Paris, France.\nD\u00e9partement de Pharmacologie, Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Paris, France.",
            "firstname": "Jean-Marc",
            "initials": "JM",
            "lastname": "Treluyer"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",
    "doi": "10.1111/bjh.20009\n10.1016/j.hoc.2015.11.004\n10.1371/journal.pone.0253986\n10.1038/nrdp.2018.10\n10.1182/blood-2014-11-607317\n10.1111/1471-0528.13786\n10.1111/bjh.17607\n10.1001/jamanetworkopen.2022.54552\n10.1002/ajh.26818\n10.1016/j.ajog.2016.05.032\n10.1016/j.eclinm.2021.101238\n10.1016/j.ejogrb.2023.08.390\n10.1111/bjh.13270\n10.1016/S0248-8663(15)60002-9\n10.1136/jamia.2009.001230\n10.1371/journal.pone.0148343\n10.1097/01.AOG.0000825972.06249.23\n10.1016/j.ogc.2004.03.006\n10.1055/s-2008-1040742\n10.1002/ijgo.12626\n10.1016/j.ajog.2008.04.016\n10.1007/s40265-017-0823-0\n10.1056/NEJMoa1704559\n10.1016/S2352-3026(23)00310-1\n10.1136/bmjopen-2020-047949\n10.1155/2016/9069054\n10.1111/bjh.17671\n10.1111/bjh.15235\n10.11124/JBISRIR-2017-003548\n10.2139/ssrn.4823771\n10.33590/emjhematol/20-00037\n10.1182/blood-2015-06-649319\n10.1016/j.ejogrb.2010.05.022\n10.1182/bloodadvances.2019001143\n10.1056/NEJM198812013192204\n10.1002/14651858.CD010378.pub3\n10.1182/bloodadvances.2024012923\n10.1002/ajh.25097",
    "journal": "British journal of haematology",
    "keywords": [
        "adverse neonatal outcome",
        "aspirin",
        "congenital abnormalities",
        "hydroxyurea",
        "perinatal and maternal outcomes",
        "pregnancy",
        "prematurity",
        "pre\u2010eclampsia",
        "sickle cell disease",
        "transfusion"
    ],
    "methods": null,
    "publication_date": "2025-02-22",
    "pubmed_id": "39984807\n27040957\n34242255\n29542687\n25800049\n26667608\n34124774\n36729452\n36594168\n27242200\n34977515\n37776703\n25522142\n26007619\n20442144\n26849801\n15200965\n8048982\n30030929\n18533123\n29039130\n28657417\n38135375\n34389570\n27403164\n34409598\n29732531\n29762306\n29762306\n26302758\n20846778\n31985807\n3054555\n28005272\n38954844\n29603363",
    "results": null,
    "title": "Maternal and perinatal outcomes of sickle cell disease in pregnancy: A nationwide study in France.",
    "xml": "<Element 'PubmedArticle' at 0x788504c74e00>"
}