{
    "abstract": "Prior studies have assessed the association between SARS-CoV-2 convalescence and subsequent in vitro fertilization (IVF) treatment, while the outcomes of couples infected during controlled ovarian stimulation (COS) were limited and controversial. The aim of this study was to clarify the effects of SARS-CoV-2 infection during COS on embryo morphokinetics and IVF clinical outcomes with the use of time-lapse monitoring.\nWe conducted a prospective cohort study of 230 couples who underwent IVF cycles between April 2023 and April 2024 in an academic fertility center. Participants were divided into four groups based on the nucleic acid testing for SARS-CoV-2 during COS: both positive (n\u2009=\u200931), female positive (n\u2009=\u200964), male positive (n\u2009=\u200920), and both negative (n\u2009=\u2009115). A time-lapse imaging system was used for embryo culture. Multivariate logistic regression and generalized linear models were performed to control for potential confounders.\nCompared with the both negative group, the both positive group had a significantly lower cleavage rate (97.4\u2009\u00b1\u20097.7% vs. 93.6\u2009\u00b1\u200911.5%; \u03b2\nSARS-CoV-2 infection in both partners affects morphokinetic parameters of embryo development with decreased cleavage rate and blastocyst formation rate, but does not influence pregnancy and neonatal outcomes after fresh embryo transfer. Our study implies that reproductive physicians should pay attention to infertile couples with SARS-CoV-2 infection during IVF treatment and should provide adequate counseling on their embryo and pregnancy outcomes.",
    "authors": [
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China.",
            "firstname": "Jialyu",
            "initials": "J",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang, China.",
            "firstname": "Yuxin",
            "initials": "Y",
            "lastname": "Liu"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China.",
            "firstname": "Leizhen",
            "initials": "L",
            "lastname": "Xia"
        },
        {
            "affiliation": "School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.",
            "firstname": "Haisheng",
            "initials": "H",
            "lastname": "Wu"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China.",
            "firstname": "Houyang",
            "initials": "H",
            "lastname": "Chen"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China.",
            "firstname": "Zhihui",
            "initials": "Z",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang, China.",
            "firstname": "Yajie",
            "initials": "Y",
            "lastname": "Liao"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China.",
            "firstname": "Xinxia",
            "initials": "X",
            "lastname": "Wan"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China.",
            "firstname": "Hong",
            "initials": "H",
            "lastname": "Chen"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China. zhaoyan1967_jx@126.com.",
            "firstname": "Yan",
            "initials": "Y",
            "lastname": "Zhao"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology and Gynecology Research Unit, Hannover Medical School, Carl- Neuberg-Strasse 1, D-30625, Hannover, Germany. vonVersen-Hoeynck.Frauke@mh-hannover.de.",
            "firstname": "Frauke",
            "initials": "F",
            "lastname": "von Versen-H\u00f6ynck"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, 318 Bayi Avenue, Donghu District, Nanchang, 330006, China. wuxingwujy@163.com.",
            "firstname": "Xingwu",
            "initials": "X",
            "lastname": "Wu"
        }
    ],
    "conclusions": "SARS-CoV-2 infection in both partners affects morphokinetic parameters of embryo development with decreased cleavage rate and blastocyst formation rate, but does not influence pregnancy and neonatal outcomes after fresh embryo transfer. Our study implies that reproductive physicians should pay attention to infertile couples with SARS-CoV-2 infection during IVF treatment and should provide adequate counseling on their embryo and pregnancy outcomes.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s12958-025-01355-6",
    "journal": "Reproductive biology and endocrinology : RB&E",
    "keywords": [
        "In vitro fertilization",
        "COVID-19",
        "Embryo morphokinetics",
        "Pregnancy",
        "SARS-CoV-2"
    ],
    "methods": null,
    "publication_date": "2025-02-27",
    "pubmed_id": "40012044\n33401657\n33315943\n34418496\n36361640\n32563676\n35527294\n34718118\n36136831\n33816526\n36333264\n37867530\n35272846\n36795183\n37440229\n31572476\n25127131\n36576971\n32750256\n36104397\n36362229\n36522363\n36142911\n35260151\n35212741\n37859985",
    "results": "Compared with the both negative group, the both positive group had a significantly lower cleavage rate (97.4\u2009\u00b1\u20097.7% vs. 93.6\u2009\u00b1\u200911.5%; \u03b2",
    "title": "Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study.",
    "xml": "<Element 'PubmedArticle' at 0x78850374cf90>"
}