{
    "abstract": "We studied the effect of tramadol on the ventilatory response to 7 min acute isocapnic hypoxia (SpO2 85.1 (SD 0.4)%) during steady mild hypercapnia (PE'CO2 0.7 kPa above normoxic baseline) in 14 healthy volunteers (seven male). The acute hypoxic response was measured before and 1 h after oral placebo or tramadol (100 mg). After tramadol, ventilation during mild hypercapnia (mean 11.28 litres min-1) was significantly less (P < 0.05) than during placebo baseline (13.93 litres min-1), tramadol baseline (14.63 litres min-1), or after placebo (14.95 litres min-1), confirming that tramadol has a small depressive effect on the hypercapnic ventilatory response. There was no significant difference in the hypoxic ventilation/SpO2 response (1 min-1 %-1) measured during the placebo baseline (0.99), placebo (1.18), tramadol baseline (0.78) or tramadol (0.68) runs. These data suggest that tramadol does not depress the hypoxic ventilatory response.",
    "authors": [
        {
            "affiliation": "Department of Medical and Radiological Science, University of Edinburgh, Royal Infirmary, UK.",
            "firstname": "P M",
            "initials": "PM",
            "lastname": "Warren"
        },
        {
            "affiliation": null,
            "firstname": "J H",
            "initials": "JH",
            "lastname": "Taylor"
        },
        {
            "affiliation": null,
            "firstname": "K E",
            "initials": "KE",
            "lastname": "Nicholson"
        },
        {
            "affiliation": null,
            "firstname": "P K",
            "initials": "PK",
            "lastname": "Wraith"
        },
        {
            "affiliation": null,
            "firstname": "G B",
            "initials": "GB",
            "lastname": "Drummond"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1093/bja/85.2.211",
    "journal": "British journal of anaesthesia",
    "keywords": [],
    "methods": null,
    "publication_date": "2000-09-19",
    "pubmed_id": "10992826",
    "results": null,
    "title": "Influence of tramadol on the ventilatory response to hypoxia in humans.",
    "xml": "<Element 'PubmedArticle' at 0x7885040e9a80>"
}