{
    "abstract": "We sought to provide updated incidence and trend data for cerebral venous thrombosis (CVT) in the United States from 2016-2020, examine the impact of the COVID-19 pandemic on CVT, and identify predictors of in-hospital mortality.\nValidated ICD-10 codes were used to identify discharges with CVT in the National Inpatient Sample (NIS). Sample weights were applied to generate nationally representative estimates, and census data were used to compute incidence rates. The first wave of the COVID-19 pandemic was defined as January-May 2020. Trend analysis was completed using Joinpoint regression.\nFrom 2016 to 2020, the incidence of CVT increased from 24.34 per 1,000,000 population per year (MPY) to 33.63 per MPY (Annual Percentage Change (APC) 8.6 %; p < 0.001). All-cause in-hospital mortality was 4.9 % [95 % CI 4.5-5.4]. On multivariable analysis, use of thrombectomy, increased age, atrial fibrillation, stroke diagnosis, infection, presence of prothrombotic hematologic conditions, lowest quartile of income, intracranial hemorrhage, and male sex were associated with in-hospital mortality. CVT incidence was similar comparing the first 5 months of 2020 and 2019 (31.37 vs 32.04; p = 0.322) with no difference in median NIHSS (2 [IQR 1-10] vs. 2 [1-9]; p = 0.959) or mortality (4.2 % vs. 5.6 %; p = 0.176).\nCVT incidence increased in the US from 2016 to 2020 while mortality did not change. Increased age, prothrombotic state, stroke diagnosis, infection, atrial fibrillation, male sex, lowest quartile of income, intracranial hemorrhage, and use of thrombectomy were associated with in-hospital mortality following CVT. During the first wave of the COVID-19 pandemic, CVT volumes and mortality were similar to the prior year.",
    "authors": [
        {
            "affiliation": "Neurology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA; Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA.",
            "firstname": "Piers",
            "initials": "P",
            "lastname": "Klein"
        },
        {
            "affiliation": "Neurology, Rhode Island Hospital, Brown University School of Medicine, Providence, USA.",
            "firstname": "Liqi",
            "initials": "L",
            "lastname": "Shu"
        },
        {
            "affiliation": "Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA; Radiation Oncology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA.",
            "firstname": "Muhammad M",
            "initials": "MM",
            "lastname": "Qureshi"
        },
        {
            "affiliation": "Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA.",
            "firstname": "Mohamad",
            "initials": "M",
            "lastname": "Abdalkader"
        },
        {
            "affiliation": "Neurology, Vancouver Stroke Program, University of British Columbia, Canada.",
            "firstname": "Thalia S",
            "initials": "TS",
            "lastname": "Field"
        },
        {
            "affiliation": "Neurology, University of Chicago, USA; Neurology, Cooper University Neuroscience Institute, Camden, USA.",
            "firstname": "James E",
            "initials": "JE",
            "lastname": "Siegler"
        },
        {
            "affiliation": "Neurology, Vancouver Stroke Program, University of British Columbia, Canada.",
            "firstname": "Lily W",
            "initials": "LW",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Neurology, Cooper University Neuroscience Institute, Camden, USA.",
            "firstname": "Karan",
            "initials": "K",
            "lastname": "Patel"
        },
        {
            "affiliation": "Neurology, Medical University of South Carolina, Charleston, USA.",
            "firstname": "Sami",
            "initials": "S",
            "lastname": "Al Kasab"
        },
        {
            "affiliation": "Neurology, Yale University, New Haven, USA.",
            "firstname": "Adam",
            "initials": "A",
            "lastname": "de Havenon"
        },
        {
            "affiliation": "Neurology, Rhode Island Hospital, Brown University School of Medicine, Providence, USA.",
            "firstname": "Shadi",
            "initials": "S",
            "lastname": "Yaghi"
        },
        {
            "affiliation": "Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Colombia, USA.",
            "firstname": "Adnan I",
            "initials": "AI",
            "lastname": "Qureshi"
        },
        {
            "affiliation": "Neurology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA; Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, USA. Electronic address: Thanh.Nguyen@bmc.org.",
            "firstname": "Thanh N",
            "initials": "TN",
            "lastname": "Nguyen"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024. Published by Elsevier Inc.",
    "doi": "10.1016/j.jstrokecerebrovasdis.2024.107651",
    "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association",
    "keywords": [
        "Incidence",
        "Intracranial",
        "Prognosis",
        "Sinus thrombosis",
        "Stroke"
    ],
    "methods": null,
    "publication_date": "2024-02-27",
    "pubmed_id": "38408574",
    "results": "From 2016 to 2020, the incidence of CVT increased from 24.34 per 1,000,000 population per year (MPY) to 33.63 per MPY (Annual Percentage Change (APC) 8.6 %; p < 0.001). All-cause in-hospital mortality was 4.9 % [95 % CI 4.5-5.4]. On multivariable analysis, use of thrombectomy, increased age, atrial fibrillation, stroke diagnosis, infection, presence of prothrombotic hematologic conditions, lowest quartile of income, intracranial hemorrhage, and male sex were associated with in-hospital mortality. CVT incidence was similar comparing the first 5 months of 2020 and 2019 (31.37 vs 32.04; p = 0.322) with no difference in median NIHSS (2 [IQR 1-10] vs. 2 [1-9]; p = 0.959) or mortality (4.2 % vs. 5.6 %; p = 0.176).",
    "title": "Trends in cerebral venous thrombosis before and during the COVID-19 pandemic: Analysis of the National Inpatient Sample.",
    "xml": "<Element 'PubmedArticle' at 0x788505c509f0>"
}