{
    "abstract": "Mechanical ventilation (MV) is an essential life support for patients with acute respiratory distress syndrome (ARDS). However, mechanical ventilation in patients with ARDS can cause ventilator-induced lung injury (VILI). Simvastatin can alleviate acute lung injury by anti-inflammatory and enhancing endothelial barrier. The present study aimed to evaluate whether simvastatin could attenuate VILI in mice with ARDS.\nMice were randomized into six groups: the sham (S), LPS (L), MV (V), LPS/MV (LV), LPS/MV/simvastatin (MS) and LPS/MV/GSK484 (MG) groups. The mice in the L group received LPS but not ventilation, the mice in the V group received only MV, and the mice in the LV, MS and MG groups received LPS and MV. Additionally, MS group were treated with simvastatin, MG group were treated with GSK484, and the other mice were injected with saline, starting three days prior to mechanical ventilation. The PaO\nAll indices were improved in group S compared with the other groups. The lung injury score and wet\u2012dry weight ratio were lower, the PaO\nSimvastatin attenuated VILI in mice with ARDS, potentially via reductions in neutrophil extracellular traps (NETs) generation and apoptosis.",
    "authors": [
        {
            "affiliation": "The Second School of Clinical Medicine, Binzhou Medical University, Yantai, 264000, Shandong Province, China.",
            "firstname": "Chao",
            "initials": "C",
            "lastname": "Ma"
        },
        {
            "affiliation": "Department of Anesthesiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, Shandong Province, China.",
            "firstname": "Yuting",
            "initials": "Y",
            "lastname": "Dai"
        },
        {
            "affiliation": "Department of Anesthesiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, Shandong Province, China.",
            "firstname": "Weiwei",
            "initials": "W",
            "lastname": "Qin"
        },
        {
            "affiliation": "Department of Pulmonary and Critical Care Medicine, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, Shandong Province, China.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Han"
        },
        {
            "affiliation": "Department of Anesthesiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, Shandong Province, China. wangxueting262@163.com.",
            "firstname": "Xueting",
            "initials": "X",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Anesthesiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, Shandong Province, China. sunlixin1221@126.com.",
            "firstname": "Lixin",
            "initials": "L",
            "lastname": "Sun"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s40001-025-02544-0",
    "journal": "European journal of medical research",
    "keywords": [
        "Acute respiratory distress syndrome",
        "Mechanical ventilation",
        "Neutrophil extracellular traps",
        "Simvastatin"
    ],
    "methods": null,
    "publication_date": "2025-04-18",
    "pubmed_id": "40247369\n35621124\n26903337\n10806138\n25304459\n35197267\n28990587\n35967320\n34648022\n36566004\n36778209\n30279549\n35269738\n31816575\n25848815\n22797452\n37218012\n33223333\n26408150\n29392731\n30888839\n25665049\n35637949\n17316425\n21184683\n12934667\n32915635\n32170015\n38291476\n31206313\n20673352",
    "results": "All indices were improved in group S compared with the other groups. The lung injury score and wet\u2012dry weight ratio were lower, the PaO",
    "title": "Simvastatin mitigates ventilator-induced lung injury in mice with acute respiratory distress syndrome via a mechanism partly dependent on neutrophil extracellular traps.",
    "xml": "<Element 'PubmedArticle' at 0x7885031fc6d0>"
}