{
    "abstract": "The novel Phoenix Sepsis Score and sepsis criteria were derived and validated using a multicountry dataset and proposed as a new definition for sepsis in children.\nTo externally validate the Phoenix Sepsis Score and sepsis criteria in a cohort of children hospitalized with suspected community-acquired sepsis.\nThis diagnostic study used data from the multicenter, multicountry Sepsis Epidemiology in Australian and New Zealand Emergency Departments (SENTINEL) study, collected from 2021 to 2023 and including 90-day follow-up. Children admitted to the hospital through 11 emergency departments in Australia and New Zealand and treated with parenteral antibiotics with either (1) a provisional diagnosis of sepsis or (2) treatment for sepsis (intravenous fluid bolus to treat poor perfusion) were included.\nDevelopment of organ dysfunction over the first 24 hours of hospitalization.\nThe main outcomes were (1) in-hospital mortality and (2) death or requirement for extracorporeal life support (ECLS) within 72 hours of hospitalization.\nA total of 6232 children were included in the analysis, with a median (IQR) age of 2.1 (0.3-7.1) years, 3386 (54.1%) male, in-hospital mortality of 60 (1.0%), and death or ECLS within 72 hours in 36 (0.6%). In this population, the worst Phoenix Sepsis Score calculated over the first 24 hours of hospitalization had an area under the precision recall curve of 0.17 (95% CI, 0.07-0.28) for predicting in-hospital mortality and 0.23 (95% CI, 0.11-0.36) for predicting death or ECLS within 72 hours. Overall, 306 children (4.9%) met the Phoenix sepsis criteria, of whom 33 (10.8%) died in the hospital (nearly half of the total number who died) and 28 (9.2%) died or required ECLS within 72 hours. The Phoenix sepsis criteria had a sensitivity of 55.0% (95% CI, 41.6%-67.9%) and positive predictive value (PPV) of 10.8% (95% CI, 7.6%-14.9%) for in-hospital mortality and sensitivity of 77.8% (95% CI, 60.8%-89.9%) and PPV of 9.2% (95% CI, 6.2%-13.0%) for death or ECLS within 72 hours. Coagulation data for the calculation of the Phoenix Sepsis Score were missing in more than 85% of children.\nIn this multicenter diagnostic study of children hospitalized with suspected sepsis, the Phoenix Sepsis Score and sepsis criteria had similar performance to the original derivation and validation cohorts. The small proportion of children meeting Phoenix sepsis criteria, missingness of data, timing of application, and lack of sensitivity for in-hospital mortality limit the clinical utility of the criteria.",
    "authors": [
        {
            "affiliation": "Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.\nClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nDepartment of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.\nDepartment of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.",
            "firstname": "Elliot",
            "initials": "E",
            "lastname": "Long"
        },
        {
            "affiliation": "Department of Emergency Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.\nDivisions of Emergency Medicine and Paediatrics, School of Medicine, University of Western Australia, Perth, Western Australia, Australia.",
            "firstname": "Meredith L",
            "initials": "ML",
            "lastname": "Borland"
        },
        {
            "affiliation": "Department of Emergency Medicine and Children's Critical Care, Gold Coast University Hospital, Southport, Queensland, Australia.\nSchool of Medicine and Dentistry, Griffith University, Southport, Queensland, Australia.\nChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.",
            "firstname": "Shane",
            "initials": "S",
            "lastname": "George"
        },
        {
            "affiliation": "Department of Emergency Medicine, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.\nFaculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.",
            "firstname": "Shefali",
            "initials": "S",
            "lastname": "Jani"
        },
        {
            "affiliation": "Middlemore Hospital, Aukland, New Zealand.\nDepartment of Surgery and Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.",
            "firstname": "Eunicia",
            "initials": "E",
            "lastname": "Tan"
        },
        {
            "affiliation": "Emergency Department, Queensland Children's Hospital, South Brisbane, Queensland, Australia.\nChild Health Research Centre, University of Queensland, Queensland, Australia.",
            "firstname": "Natalie",
            "initials": "N",
            "lastname": "Phillips"
        },
        {
            "affiliation": "Department of Emergency Medicine, Women and Children's Hospital, Adelaide, South Australia, Australia.\nDepartment of Acute Care Medicine, University of Adelaide, Adelaide, South Australia, Australia.",
            "firstname": "Amit",
            "initials": "A",
            "lastname": "Kochar"
        },
        {
            "affiliation": "Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nPaediatric Emergency Department, Monash Medical Centre, Monash Health, Victoria, Australia.\nDepartment of Paediatrics, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.",
            "firstname": "Simon",
            "initials": "S",
            "lastname": "Craig"
        },
        {
            "affiliation": "Department of Paediatrics, Royal Darwin Hospital, Tiwi, Northern Territory, Australia.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Lithgow"
        },
        {
            "affiliation": "Department of Emergency Medicine, Sydney Children's Hospital, Randwick, New South Wales, Australia.\nSchool of Women's and Children's Health, University of New South Wales, Kensington, New South Wales, Australia.",
            "firstname": "Arjun",
            "initials": "A",
            "lastname": "Rao"
        },
        {
            "affiliation": "Department of Surgery and Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.\nChildren's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.",
            "firstname": "Stuart",
            "initials": "S",
            "lastname": "Dalziel"
        },
        {
            "affiliation": "Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.\nClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nDepartment of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.\nDepartment of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.",
            "firstname": "Ed",
            "initials": "E",
            "lastname": "Oakley"
        },
        {
            "affiliation": "Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nDepartment of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.",
            "firstname": "Stephen",
            "initials": "S",
            "lastname": "Hearps"
        },
        {
            "affiliation": "Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nDepartment of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.\nPaediatric Intensive Care Unit, The Royal Children's Hospital, Parkville, Victoria, Australia.",
            "firstname": "Ben",
            "initials": "B",
            "lastname": "Gelbart"
        },
        {
            "affiliation": "Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nDepartment of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.\nDepartment of General Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.",
            "firstname": "Sarah",
            "initials": "S",
            "lastname": "McNab"
        },
        {
            "affiliation": "Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia.\nDivision of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.",
            "firstname": "Fran",
            "initials": "F",
            "lastname": "Balamuth"
        },
        {
            "affiliation": "Nemours Children's Health and Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.",
            "firstname": "Scott L",
            "initials": "SL",
            "lastname": "Weiss"
        },
        {
            "affiliation": "Departments of Pediatrics and Emergency Medicine, the George Washington School of Medicine and Health Sciences, and Children's National Hospital, Washington, DC.",
            "firstname": "Nathan",
            "initials": "N",
            "lastname": "Kuppermann"
        },
        {
            "affiliation": "Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.",
            "firstname": "Charlotte",
            "initials": "C",
            "lastname": "Brad"
        },
        {
            "affiliation": "Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.",
            "firstname": "Amanda",
            "initials": "A",
            "lastname": "Williams"
        },
        {
            "affiliation": "Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.\nClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.\nDepartment of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.\nDepartment of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.",
            "firstname": "Franz E",
            "initials": "FE",
            "lastname": "Babl"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1001/jamanetworkopen.2025.1412\n10.1016/S0140-6736(19)32989-7\n10.1097/01.PCC.0000149131.72248.E6\n10.1111/acem.12610\n10.1542/peds.2021-052888D\n10.1001/jama.2024.0196\n10.1136/bmjopen-2023-077471\n10.1136/emermed-2017-206727\n10.1136/bmj.h5527\n10.1111/apa.15602\n10.1111/1742-6723.14381\n10.1001/jamanetworkopen.2024.20579\n10.1097/PCC.0000000000002689\n10.1542/peds.2021-052565\n10.1097/CCM.0000000000005294\n10.1001/jama.2024.0179",
    "journal": "JAMA network open",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-03-21",
    "pubmed_id": "40116825\n31954465\n15636651\n25778743\n34970683\n38245897\n38216206\n28855237\n26511519\n33000491\n38403429\n39008301\n33790212\n35611643\n34612847\n38245889",
    "results": "A total of 6232 children were included in the analysis, with a median (IQR) age of 2.1 (0.3-7.1) years, 3386 (54.1%) male, in-hospital mortality of 60 (1.0%), and death or ECLS within 72 hours in 36 (0.6%). In this population, the worst Phoenix Sepsis Score calculated over the first 24 hours of hospitalization had an area under the precision recall curve of 0.17 (95% CI, 0.07-0.28) for predicting in-hospital mortality and 0.23 (95% CI, 0.11-0.36) for predicting death or ECLS within 72 hours. Overall, 306 children (4.9%) met the Phoenix sepsis criteria, of whom 33 (10.8%) died in the hospital (nearly half of the total number who died) and 28 (9.2%) died or required ECLS within 72 hours. The Phoenix sepsis criteria had a sensitivity of 55.0% (95% CI, 41.6%-67.9%) and positive predictive value (PPV) of 10.8% (95% CI, 7.6%-14.9%) for in-hospital mortality and sensitivity of 77.8% (95% CI, 60.8%-89.9%) and PPV of 9.2% (95% CI, 6.2%-13.0%) for death or ECLS within 72 hours. Coagulation data for the calculation of the Phoenix Sepsis Score were missing in more than 85% of children.",
    "title": "External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis.",
    "xml": "<Element 'PubmedArticle' at 0x7885043873d0>"
}