{
    "abstract": "Existing literature supports the association between atypical phospholipid antibodies - anti-phosphatidylserine/prothrombin antibodies (aPS/PT) and adverse pregnancy outcomes. This study aimed to investigate the relationship between aPS/PT and premature rupture of membranes (PROM).\nA retrospective cohort study analysis was conducted on 408 pregnant women who had experienced at least one unexplained miscarriage. They were tested for aPS/PT IgM and IgG, and clinical data, test results, and follow-up pregnancy outcomes were collected.\nA positive correlation was observed between aPS/PT IgM or IgG and PROM in both single-factor and multi-factor regression analysis. After adjusting for potential confounders, the odds ratio (OR) values for aPS/PT IgM and aPS/PT IgG were 1.03 (95\u202f% CI: 1-1.05, P\u202f=\u202f0.025) and 1.03 (95\u202f% CI: 1.01-1.06, P\u202f=\u202f0.016) respectively. When aPS/PT was divided in three groups, djusted OR values for aPS/PT IgG of the third tertiles compared to the first tertiles (were 2.11(95\u202f% CI: 1.11-4, P\u202f=\u202f0.022). Subgroup analysis supported these findings. Curve fitting revealed a linear relationship between aPS/PT IgM and aPS/PT IgG with PROM.\nThis study suggests that aPS/PT IgG and aPS/PT IgM are independent risk factors for premature rupture of membranes, with aPS/PT IgG showing a higher significance compared to aPS/PT IgM.",
    "authors": [
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Jie",
            "initials": "J",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Neonate Department, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Ge",
            "initials": "G",
            "lastname": "Zheng"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Liqiong",
            "initials": "L",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Xueke",
            "initials": "X",
            "lastname": "Guo"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Xia",
            "initials": "X",
            "lastname": "Fang"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Wenmei",
            "initials": "W",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Yan",
            "initials": "Y",
            "lastname": "Tu"
        },
        {
            "affiliation": "Neonate Department, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China.",
            "firstname": "Kexin",
            "initials": "K",
            "lastname": "Sun"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University,\u00a0Wenzhou,\u00a0Zhejiang Province,\u00a0China. Electronic address: caizhuhua12@163.com.",
            "firstname": "Zhuhua",
            "initials": "Z",
            "lastname": "Cai"
        }
    ],
    "conclusions": "This study suggests that aPS/PT IgG and aPS/PT IgM are independent risk factors for premature rupture of membranes, with aPS/PT IgG showing a higher significance compared to aPS/PT IgM.",
    "copyrights": "Copyright \u00a9 2024. Published by Elsevier B.V.",
    "doi": "10.1016/j.jri.2024.104421",
    "journal": "Journal of reproductive immunology",
    "keywords": [
        "Anti-phosphatidylserine/prothrombin antibodies",
        "Pregnancy Outcomes",
        "Premature rupture of membranes"
    ],
    "methods": null,
    "publication_date": "2024-12-29",
    "pubmed_id": "39732056",
    "results": "A positive correlation was observed between aPS/PT IgM or IgG and PROM in both single-factor and multi-factor regression analysis. After adjusting for potential confounders, the odds ratio (OR) values for aPS/PT IgM and aPS/PT IgG were 1.03 (95\u202f% CI: 1-1.05, P\u202f=\u202f0.025) and 1.03 (95\u202f% CI: 1.01-1.06, P\u202f=\u202f0.016) respectively. When aPS/PT was divided in three groups, djusted OR values for aPS/PT IgG of the third tertiles compared to the first tertiles (were 2.11(95\u202f% CI: 1.11-4, P\u202f=\u202f0.022). Subgroup analysis supported these findings. Curve fitting revealed a linear relationship between aPS/PT IgM and aPS/PT IgG with PROM.",
    "title": "The relation of anti-phosphatidylserine/prothrombin antibodies and premature rupture of membranes: A retrospective cohort study.",
    "xml": "<Element 'PubmedArticle' at 0x788504ce7510>"
}