{
    "abstract": "The objective of this first-in-human study was to investigate the radiosynthesis, and the preliminary safety, biodistribution, and organ radiation dosimetry of the positron emission tomography (PET) imaging tracer methyl N\nA multi-step high molar activity tracer radiosynthesis was devised to produce doses. Eight healthy human participants (four male and four female), aged 56-75, received a bolus intravenous injection of [\nTracer was routinely produced in good radiochemical yields and as suitable high molar activity doses for injection. The [\nInjection of [",
    "authors": [
        {
            "affiliation": "Rio Pharmaceuticals, Inc., 18 Elsie St., San Francisco, CA 94110, USA. Electronic address: chihkai.chao@gmail.com.",
            "firstname": "Chih-Kai",
            "initials": "CK",
            "lastname": "Chao"
        },
        {
            "affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: joseph.blecha@ucsf.edu.",
            "firstname": "Joseph",
            "initials": "J",
            "lastname": "Blecha"
        },
        {
            "affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA.",
            "firstname": "Ilona",
            "initials": "I",
            "lastname": "Polvoy"
        },
        {
            "affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: ryanmichael.nillo@uscf.edu.",
            "firstname": "Ryan Michael",
            "initials": "RM",
            "lastname": "Nillo"
        },
        {
            "affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: youngho.seo@ucsf.edu.",
            "firstname": "Youngho",
            "initials": "Y",
            "lastname": "Seo"
        },
        {
            "affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: david.m.wilson@ucsf.edu.",
            "firstname": "David M",
            "initials": "DM",
            "lastname": "Wilson"
        },
        {
            "affiliation": "Rio Pharmaceuticals, Inc., 18 Elsie St., San Francisco, CA 94110, USA. Electronic address: john.forsayeth@riopharmaceuticals.com.",
            "firstname": "John R",
            "initials": "JR",
            "lastname": "Forsayeth"
        },
        {
            "affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: henry.vanbrocklin@ucsf.edu.",
            "firstname": "Henry F",
            "initials": "HF",
            "lastname": "VanBrocklin"
        },
        {
            "affiliation": "Rio Pharmaceuticals, Inc., 18 Elsie St., San Francisco, CA 94110, USA. Electronic address: jgerdesum@gmail.com.",
            "firstname": "John M",
            "initials": "JM",
            "lastname": "Gerdes"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 The Authors. Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.nucmedbio.2025.108992",
    "journal": "Nuclear medicine and biology",
    "keywords": [
        "Dosimetry",
        "EAAT2",
        "Fluorine-18",
        "Human",
        "PET",
        "Tracer"
    ],
    "methods": null,
    "publication_date": "2025-02-07",
    "pubmed_id": "39913962",
    "results": null,
    "title": "First-in-human healthy volunteer dosimetry studies of the excitatory amino acid transporter 2 (EAAT2) PET imaging tracer methyl N",
    "xml": "<Element 'PubmedArticle' at 0x7885031a2fc0>"
}