{
    "abstract": "Exertion-induced desaturation (EID) is a common complication of numerous pulmonary disorders and often treated with supplementary oxygen during exertion. We performed a systematic review and meta-analysis of randomised clinical trials (RCTs) to evaluate the efficacy of supplementary oxygen for EID in pulmonary disorders.\nMedline and Embase were systematically searched from July 2022 to June 2023 following PRISMA guidelines. RCTs that met predefined inclusion criteria were included. Means and standard deviations were extracted and standardised mean differences (SMDs), the difference in means between groups divided by the standard deviation, and 95% confidence intervals were calculated. Exercise capacity was the primary outcome; exercise dyspnoea, baseline dyspnoea and quality of life were secondary objectives. The immediate, post-rehabilitation, short-term and ambulatory effects of oxygen supplementation were evaluated.\nWe included 15 studies in our analysis. Oxygen supplementation to treat adult EID had been investigated for COPD and idiopathic pulmonary fibrosis (IPF) only. Oxygen supplementation was superior to placebo for its immediate effect on exercise capacity for COPD (SMD 0.42, 95% CI 0.15-0.69, I\nOur study revealed the efficacy of supplemental oxygen for EID and only a positive immediate effect on exercise capacity and dyspnoea, but no improvement in other short-term or long-term measures.",
    "authors": [
        {
            "affiliation": "Redington-Fairview General Hospital, Skowhegan, ME, USA.",
            "firstname": "Paraschos",
            "initials": "P",
            "lastname": "Archontakis Barakakis"
        },
        {
            "affiliation": "Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.",
            "firstname": "Adam",
            "initials": "A",
            "lastname": "Wolfe"
        },
        {
            "affiliation": "Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.",
            "firstname": "Andrei",
            "initials": "A",
            "lastname": "Schwartz"
        },
        {
            "affiliation": "Department of Medicine, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, USA.",
            "firstname": "Gabriel J",
            "initials": "GJ",
            "lastname": "Hernandez Romero"
        },
        {
            "affiliation": "Medicine Institute, Geisinger Medical Center, Danville, PA, USA.",
            "firstname": "Vipul",
            "initials": "V",
            "lastname": "Gidwani"
        },
        {
            "affiliation": "Medicine Institute, Geisinger Medical Center, Danville, PA, USA.",
            "firstname": "Shaylika",
            "initials": "S",
            "lastname": "Chauhan"
        },
        {
            "affiliation": "School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Japan.",
            "firstname": "Shinichi",
            "initials": "S",
            "lastname": "Arizono"
        },
        {
            "affiliation": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.\nDepartment of Medicine, Veterans Affairs Medical Center, Cincinnati, OH, USA.",
            "firstname": "Ralph J",
            "initials": "RJ",
            "lastname": "Panos"
        },
        {
            "affiliation": "Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.\nVeterans Rural Health Resource Center, VA Office of Rural Health, and Center for Access and Delivery Research and Evaluation at the Iowa City VA Healthcare System, Iowa City, IA, USA.",
            "firstname": "Spyridon",
            "initials": "S",
            "lastname": "Fortis"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9The authors 2024.",
    "doi": "10.1183/23120541.00411-2024\n10.1111/j.1445-5994.2010.02169.x\n10.1164/rccm.200302-219OC\n10.1016/j.resp.2013.10.002\n10.1164/arrd.1986.134.6.1135\n10.1164/rccm.2201003\n10.1378/chest.09-2555\n10.1183/09031936.00150314\n10.1378/chest.08-0520\n10.1164/rccm.200604-488OC\n10.1002/14651858.CD006429.pub3\n10.1001/jamanetworkopen.2021.29967\n10.1371/journal.pmed.1000100\n10.1136/bmj.d5928\n10.1186/1471-2288-14-135\n10.1136/bmj.d549\n10.1002/sim.1186\n10.1136/bmj.327.7414.557\n10.1136/bmj.39489.470347.AD\n10.1164/rccm.202009-3608ST\n10.1136/thoraxjnl-2015-206865\n10.1002/14651858.CD004356.pub3\n10.4187/respcare.01469\n10.1164/rccm.200212-1525OC\n10.1016/j.ccm.2019.02.004\n10.1002/14651858.CD005372.pub2\n10.15326/jcopdf.3.1.2015.0146\n10.1164/ajrccm/143.2.219\n10.1378/chest.128.4.2025\n10.1183/09031936.01.00082201\n10.1378/chest.81.1.6\n10.4187/respcare.10278\n10.1016/j.rmed.2017.08.023\n10.1016/j.chest.2021.04.059\n10.1007/s00408-012-9443-3",
    "journal": "ERJ open research",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-12-10",
    "pubmed_id": "39655174\n20059599\n12917227\n24121092\n3098145\n12204862\n20605816\n25359355\n18625667\n16825656\n27886372\n34665242\n19621070\n22008217\n25524443\n21310794\n12111919\n12958120\n18436948\n33185464\n25870317\n15846710\n22325845\n12869359\n31078216\n17443585\n28848863\n1990931\n16236851\n11510809\n6797795\n36150747\n28947026\n34625179\n23283384",
    "results": "We included 15 studies in our analysis. Oxygen supplementation to treat adult EID had been investigated for COPD and idiopathic pulmonary fibrosis (IPF) only. Oxygen supplementation was superior to placebo for its immediate effect on exercise capacity for COPD (SMD 0.42, 95% CI 0.15-0.69, I",
    "title": "Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation.",
    "xml": "<Element 'PubmedArticle' at 0x7885031a2750>"
}