{
    "abstract": "The determinants of health-related quality of life in inflammatory bowel disease are not completely understood. The present study aimed to assess two factors in patients with inflammatory bowel disease: a) whether health-related quality of life is independently associated with both bowel disease severity and psychological disorder, and b) whether Crohn's disease is associated with more marked psychological disorder than ulcerative colitis.\n116/170 (68%) consecutive patients with inflammatory bowel disease attending a GI clinic (37 patients with ulcerative colitis, 75 patients with Crohn's disease, and four unspecified) completed the following self-report questionnaires: demographic details, a modified disease activity index, a total severity measure, the Hospital Anxiety and Depression Scale, and the Short Form-36.\nThirty patients (25.9%) scored 11 or more on either the depression or anxiety subscales of the Hospital Anxiety and Depression Scale indicating probable psychological disorder; 55% (47.4%) scored over 8 indicating possible psychological disorder. Stepwise multiple regression analyses showed that both psychological symptoms and disease severity or activity contributed independently to impaired health-related quality of life. After severity of disease was taken into account, there were no significant differences between Crohn's disease and ulcerative colitis in terms of depression scores and health-related quality of life.\nThe presence of psychological disorder in inflammatory bowel disease contributes to poor health-related quality of life, regardless of the severity of the condition. Detection and treatment of psychological disorder in inflammatory bowel disease carries the potential to improve health-related quality of life for these patients.",
    "authors": [
        {
            "affiliation": "School of Psychiatry and Behavioural Sciences, University of Manchester, United Kingdom.",
            "firstname": "Elspeth",
            "initials": "E",
            "lastname": "Guthrie"
        },
        {
            "affiliation": null,
            "firstname": "Judy",
            "initials": "J",
            "lastname": "Jackson"
        },
        {
            "affiliation": null,
            "firstname": "Jon",
            "initials": "J",
            "lastname": "Shaffer"
        },
        {
            "affiliation": null,
            "firstname": "David",
            "initials": "D",
            "lastname": "Thompson"
        },
        {
            "affiliation": null,
            "firstname": "Barbara",
            "initials": "B",
            "lastname": "Tomenson"
        },
        {
            "affiliation": null,
            "firstname": "Francis",
            "initials": "F",
            "lastname": "Creed"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1111/j.1572-0241.2002.05842.x",
    "journal": "The American journal of gastroenterology",
    "keywords": [],
    "methods": null,
    "publication_date": "2002-08-23",
    "pubmed_id": "12190166",
    "results": "Thirty patients (25.9%) scored 11 or more on either the depression or anxiety subscales of the Hospital Anxiety and Depression Scale indicating probable psychological disorder; 55% (47.4%) scored over 8 indicating possible psychological disorder. Stepwise multiple regression analyses showed that both psychological symptoms and disease severity or activity contributed independently to impaired health-related quality of life. After severity of disease was taken into account, there were no significant differences between Crohn's disease and ulcerative colitis in terms of depression scores and health-related quality of life.",
    "title": "Psychological disorder and severity of inflammatory bowel disease predict health-related quality of life in ulcerative colitis and Crohn's disease.",
    "xml": "<Element 'PubmedArticle' at 0x78850216ed40>"
}