{
    "abstract": "To analyze the fever of unknown origin (FUO) etiology and clinical characteristics and determine the diagnostic value of common inflammatory parameters.\nA total of 853 patients with classic FUO were prospectively enrolled from January 2014 to May 2021. According to the etiological diagnosis, the patients were divided according to etiology: infectious diseases (n = 430); non-infectious inflammatory diseases [NIIDs] (n = 153); neoplastic diseases (n = 125); miscellaneous diseases (n = 48); and no identifiable etiology (n = 97). The clinical features and common inflammatory parameters were analyzed.\nThe clinical characteristics and common inflammatory parameters varied among the FUO patients with different etiologies. The tuberculosis T lymphocyte spot test (T-SPOT.TB) and C-reactive protein (CRP) level might be used as indicators to diagnose infections in patients with FUO. Female gender, young age, high white blood cell (WBC) count and percentage of neutrophil percent (NP), high erythrocyte sedimentation rate (ESR), and elevated serum ferritin (SF) level contributed to the diagnosis of NIIDs. Male gender, old age, low hemoglobin (HB) concentration and platelet (PLT) count, and high lactate dehydrogenase (LDH) and SF levels contributed to the diagnosis of neoplastic diseases. Male gender, old age, and low LDH and SF levels contributed to the diagnosis of infectious diseases. The procalcitonin (PCT) and interleukin-6 (IL-6) levels were highest in FUO patients with neoplastic diseases.\nInfectious diseases are the most frequent cause of FUO, followed by NIIDs. The clinical characteristics and common inflammatory markers have significant value in determining the etiology of FUO.",
    "authors": [
        {
            "affiliation": "Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.",
            "firstname": "Nana",
            "initials": "N",
            "lastname": "Xie"
        },
        {
            "affiliation": "Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.",
            "firstname": "Wencong",
            "initials": "W",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.",
            "firstname": "Fangbing",
            "initials": "F",
            "lastname": "Tian"
        },
        {
            "affiliation": "Department of Infectious Diseases, Ezhou Central Hospital, Ezhou, Hubei 436099, China.",
            "firstname": "Wenjin",
            "initials": "W",
            "lastname": "Sun"
        },
        {
            "affiliation": "Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.",
            "firstname": "Mingyou",
            "initials": "M",
            "lastname": "Xing"
        },
        {
            "affiliation": "Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: ruanqiurong@sina.com.",
            "firstname": "Qiurong",
            "initials": "Q",
            "lastname": "Ruan"
        },
        {
            "affiliation": "Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: songsingsjx@sina.com.",
            "firstname": "Jianxin",
            "initials": "J",
            "lastname": "Song"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025. Published by Elsevier Inc.",
    "doi": "10.1016/j.diagmicrobio.2025.116801",
    "journal": "Diagnostic microbiology and infectious disease",
    "keywords": [
        "Clinical characteristics",
        "Etiology",
        "Fever of unknown origin (FUO)",
        "Infection",
        "Pyrexia of unknown origin"
    ],
    "methods": null,
    "publication_date": "2025-03-23",
    "pubmed_id": "40120295",
    "results": "The clinical characteristics and common inflammatory parameters varied among the FUO patients with different etiologies. The tuberculosis T lymphocyte spot test (T-SPOT.TB) and C-reactive protein (CRP) level might be used as indicators to diagnose infections in patients with FUO. Female gender, young age, high white blood cell (WBC) count and percentage of neutrophil percent (NP), high erythrocyte sedimentation rate (ESR), and elevated serum ferritin (SF) level contributed to the diagnosis of NIIDs. Male gender, old age, low hemoglobin (HB) concentration and platelet (PLT) count, and high lactate dehydrogenase (LDH) and SF levels contributed to the diagnosis of neoplastic diseases. Male gender, old age, and low LDH and SF levels contributed to the diagnosis of infectious diseases. The procalcitonin (PCT) and interleukin-6 (IL-6) levels were highest in FUO patients with neoplastic diseases.",
    "title": "Fever of unknown origin: Clinical significance of the etiology and common inflammatory parameters.",
    "xml": "<Element 'PubmedArticle' at 0x788502e7cea0>"
}