{
    "abstract": "Uterine atony is a major contributor to postpartum hemorrhage. We previously proposed the novel histological concept of postpartum acute myometritis (PAM) to elucidate the pathophysiology of uterine atony. This concept involves the infiltration of macrophages and neutrophils, as well as mast cell and complement activation in the myometrium. However, the pathological mechanism underlying uterine atony in the context of PAM remains unclear. Herein, we focused on uterine contraction-associated proteins (CAPs) including connexin 43 (Cx43), oxytocin receptors (OXR), prostaglandin receptors EP1, EP3, FP, and protease-activated receptor (PAR)-1. This follow-up study aimed to compare CAP expression between PAM and control groups. We selected 38 PAM subjects from the cases enrolled in our amniotic fluid embolism registry between 2011 and 2018. Control tissues from 10 parturients were collected during cesarean section. We stained the myometrial tissues with the following CAP markers, inflammatory cell markers, and other markers: Cx43, OXR, EP1, EP3, FP, PAR-1, C5a receptor, tryptase, neutrophil elastase, CD68, \u03b2-actin, and Na",
    "authors": [
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: tomoakingdom@outlook.jp.",
            "firstname": "Tomoaki",
            "initials": "T",
            "lastname": "Oda"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Naoaki",
            "initials": "N",
            "lastname": "Tamura"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Rui",
            "initials": "R",
            "lastname": "Ide"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Kenta",
            "initials": "K",
            "lastname": "Kawai"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Megumi",
            "initials": "M",
            "lastname": "Narumi"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Masako",
            "initials": "M",
            "lastname": "Matsumoto"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Yukiko",
            "initials": "Y",
            "lastname": "Kohmura-Kobayashi"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Naomi",
            "initials": "N",
            "lastname": "Furuta-Isomura"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Chizuko",
            "initials": "C",
            "lastname": "Yaguchi"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Toshiyuki",
            "initials": "T",
            "lastname": "Uchida"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Kazunao",
            "initials": "K",
            "lastname": "Suzuki"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Naohiro",
            "initials": "N",
            "lastname": "Kanayama"
        },
        {
            "affiliation": "Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.",
            "firstname": "Hiroaki",
            "initials": "H",
            "lastname": "Itoh"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jri.2024.104299",
    "journal": "Journal of reproductive immunology",
    "keywords": [
        "Acute inflammation",
        "Amniotic fluid embolism",
        "Contraction-associated protein",
        "Postpartum hemorrhage",
        "Uterine atony"
    ],
    "methods": null,
    "publication_date": "2024-07-14",
    "pubmed_id": "39002426",
    "results": null,
    "title": "Postpartum acute myometritis suppresses expression of contraction-associated proteins in the gravid uterus.",
    "xml": "<Element 'PubmedArticle' at 0x7885065b8400>"
}