{
    "abstract": "Endotracheal intubation and mechanical ventilation in individuals experiencing acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with several complications. Therefore, utilizing noninvasive positive pressure ventilation (NIPPV) is the suggested initial management for these individuals. The current study was done to assess and compare the clinical and physiological parameters before and after the application of NIPPV and also to evaluate the outcomes of NIPPV.\nA prospective observational study was conducted on 50 patients with COPD experiencing acute exacerbations. These patients were treated with NIPPV. Measurements of blood pressure, respiratory rate (RR), heart rate (HR), dyspnea using the modified Borg scale, and arterial blood gas (ABG) parameters (pH, PaCO2, and PaO2) were recorded at baseline, one hour, six hours, 24 hours, and daily until discharge. The study's outcomes included the subjects who successfully underwent NIPPV and failed during NIPPV.\nNIPPV effectively reduced the dyspnea score from 7.24 \u00b1 1.58 at baseline to 5.53 \u00b1 1.82 at one hour, 4.11 \u00b1 1.75 at six hours, 2.60 \u00b1 1.03 at 24 hours, and 1.26 \u00b1 0.44 at the time of discharge. Significant improvements were also observed in HR\u00a0and RR\u00a0(\nNIPPV was successful in 42 (84%)\u00a0patients, with improvements in ABG and pH for early recovery and reduced hospital stay.",
    "authors": [
        {
            "affiliation": "Department of Pulmonary Medicine, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, IND.",
            "firstname": "Mahesh",
            "initials": "M",
            "lastname": "Gudelli"
        },
        {
            "affiliation": "Department of General Medicine, Government Medical College, Mahabubnagar, IND.",
            "firstname": "Swetha",
            "initials": "S",
            "lastname": "K"
        },
        {
            "affiliation": "Department of General Medicine, Government Medical College, Kannur, IND.",
            "firstname": "Praisy Thomas",
            "initials": "PT",
            "lastname": "Kalathil"
        },
        {
            "affiliation": "Department of General Medicine, Krishna Institute of Medical Sciences (KIMS), Karad, IND.",
            "firstname": "Omkar",
            "initials": "O",
            "lastname": "Pimple"
        },
        {
            "affiliation": "Department of General Medicine, Dr. B. R. Ambedkar Medical College, Bangalore, IND.",
            "firstname": "Afreen",
            "initials": "A",
            "lastname": "Shahid"
        },
        {
            "affiliation": "Department of General Medicine, Rajarajeshwari Medical College and Hospital, Bangalore, IND.",
            "firstname": "Nycy",
            "initials": "N",
            "lastname": "Chandradas"
        },
        {
            "affiliation": "Department of General Medicine, University College of Medical Sciences, New Delhi, IND.",
            "firstname": "Prerit",
            "initials": "P",
            "lastname": "Sharma"
        },
        {
            "affiliation": "Department of Pulmonary Medicine, Yashoda Hospitals, Secunderabad, IND.",
            "firstname": "Gangadhar Reddy",
            "initials": "GR",
            "lastname": "Mallu"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024, Gudelli et al.",
    "doi": "10.7759/cureus.62746",
    "journal": "Cureus",
    "keywords": [
        "arterial blood gas",
        "chronic obstructive pulmonary disease",
        "dyspnoea",
        "heart rate",
        "non-invasive positive pressure ventilation",
        "respiratory rate"
    ],
    "methods": null,
    "publication_date": "2024-07-22",
    "pubmed_id": "39036269\n30846476\n33800097\n30219316\n27080997\n31988545\n27162654\n19897823\n34265615\n24049265\n31632871\n28702957\n32205957\n23103736\n20931029\n24339488\n19281088\n23562934\n27386061",
    "results": "NIPPV effectively reduced the dyspnea score from 7.24 \u00b1 1.58 at baseline to 5.53 \u00b1 1.82 at one hour, 4.11 \u00b1 1.75 at six hours, 2.60 \u00b1 1.03 at 24 hours, and 1.26 \u00b1 0.44 at the time of discharge. Significant improvements were also observed in HR\u00a0and RR\u00a0(",
    "title": "Effectiveness and Outcomes of Noninvasive Positive Pressure Ventilation in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease.",
    "xml": "<Element 'PubmedArticle' at 0x788506b4aa70>"
}