{
    "abstract": "A challenge in the treatment of patients with head and neck cancer is the management of occult cervical lymph node (LN) metastases. Single-fiber reflectance (SFR) spectroscopy has the potential to detect physiological tissue changes that occur in a positive LN. This pilot study aimed to investigate whether SFR spectroscopy could serve as an alternative or additional technique to detect cervical lymph node metastases.\nWe performed intraoperative SFR spectroscopy measurements of LNs with and without malignancies. We analyzed if physiological and scattering parameters were significantly altered in positive LNs.\nNine patients with a total of nineteen LNs were included. Three parameters, blood volume fraction (BVF), microvascular saturation (StO\nThis proof of principle study is a first step in the development of an SFR spectroscopy technique to detect LN metastases in real time. A next step towards this goal is replicating these results in LNs with smaller metastases and in a larger cohort of patients. This future study will combine SFR spectroscopy with fine-needle aspiration, using the same needle, to perform preoperative in vivo measurements.",
    "authors": [
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Center for Optical Diagnostics and Therapy, Rotterdam, the Netherlands.",
            "firstname": "Ois\u00edn",
            "initials": "O",
            "lastname": "Bugter"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Center for Optical Diagnostics and Therapy, Rotterdam, the Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Pathology, Rotterdam, the Netherlands.",
            "firstname": "Yassine",
            "initials": "Y",
            "lastname": "Aaboubout"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Pathology, Rotterdam, the Netherlands.",
            "firstname": "Mahesh",
            "initials": "M",
            "lastname": "Algoe"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Center for Optical Diagnostics and Therapy, Rotterdam, the Netherlands.",
            "firstname": "Henri\u00ebtte S",
            "initials": "HS",
            "lastname": "de Bruijn"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands.",
            "firstname": "Stijn",
            "initials": "S",
            "lastname": "Keereweer"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands.",
            "firstname": "Aniel",
            "initials": "A",
            "lastname": "Sewnaik"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands.",
            "firstname": "Dominiek A",
            "initials": "DA",
            "lastname": "Monserez"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Pathology, Rotterdam, the Netherlands.",
            "firstname": "Senada",
            "initials": "S",
            "lastname": "Koljenovi\u0107"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands. Electronic address: j.hardillo@erasmusmc.nl.",
            "firstname": "Jose A U",
            "initials": "JAU",
            "lastname": "Hardillo"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Center for Optical Diagnostics and Therapy, Rotterdam, the Netherlands.",
            "firstname": "Dominic J",
            "initials": "DJ",
            "lastname": "Robinson"
        },
        {
            "affiliation": "Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, the Netherlands.",
            "firstname": "Robert J",
            "initials": "RJ",
            "lastname": "Baatenburg de Jong"
        }
    ],
    "conclusions": "This proof of principle study is a first step in the development of an SFR spectroscopy technique to detect LN metastases in real time. A next step towards this goal is replicating these results in LNs with smaller metastases and in a larger cohort of patients. This future study will combine SFR spectroscopy with fine-needle aspiration, using the same needle, to perform preoperative in vivo measurements.",
    "copyrights": "Copyright \u00a9 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.",
    "doi": "10.1016/j.oraloncology.2021.105627",
    "journal": "Oral oncology",
    "keywords": [],
    "methods": null,
    "publication_date": "2021-11-27",
    "pubmed_id": "34826688",
    "results": "Nine patients with a total of nineteen LNs were included. Three parameters, blood volume fraction (BVF), microvascular saturation (StO",
    "title": "Detecting head and neck lymph node metastases with white light reflectance spectroscopy; a pilot study.",
    "xml": "<Element 'PubmedArticle' at 0x7885023bde90>"
}