{
    "abstract": "The inadequacies of the currently available treatment options for leishmaniasis, a highly prevalent but neglected tropical disease caused by protozoan parasites, urge the discovery and development of novel, safe, and efficacious antileishmanial drugs. In continuation of our work on N, N', N\u2033-trisubstituted guanidines, which have shown promising results, we present in this study a series of new derivatives with further improved activity against the species Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) infantum and Leishmania (Viannia) braziliensis. This enhancement was achieved by replacing the benzoyl group as one of the three guanidine substituents of the starting structures with an acridinyl group, which consistently decreased the IC",
    "authors": [
        {
            "affiliation": "Fine Organic Chemistry Lab. Department of Chemistry and Biochemistry. Faculty of Science and Technology. University of Sao Paulo State (Unesp). Roberto Simonsen, 305 - 19060080. Presidente Prudente, Brazil. Electronic address: luana.anjos@unesp.br.",
            "firstname": "Luana",
            "initials": "L",
            "lastname": "Ribeiro Dos Anjos"
        },
        {
            "affiliation": "Infectious Disease Laboratory-LADIC, Federal University of Parna\u00edba Delta-UFDPar, Campus Ministro Reis Velloso, S\u00e3o Benedito, Parna\u00edba 64202-020, Brazil. Electronic address: julyannesaraiva@gmail.com.",
            "firstname": "Julyanne Maria",
            "initials": "JM",
            "lastname": "Saraiva de Souza"
        },
        {
            "affiliation": "Infectious Disease Laboratory-LADIC, Federal University of Parna\u00edba Delta-UFDPar, Campus Ministro Reis Velloso, S\u00e3o Benedito, Parna\u00edba 64202-020, Brazil. Electronic address: sousaairtonlucas@gmail.com.",
            "firstname": "Airton Lucas",
            "initials": "AL",
            "lastname": "Souza Dos Santos"
        },
        {
            "affiliation": "Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 38, A-1090, Vienna, Austria. Electronic address: anna.fabisikova@univie.ac.at.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Fabisikova"
        },
        {
            "affiliation": "Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 38, A-1090, Vienna, Austria. Electronic address: michael.abraham@univie.ac.at.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Klemm-Abraham"
        },
        {
            "affiliation": "Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 38, A-1090, Vienna, Austria; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 38, A-1090, Vienna, Austria. Electronic address: martin.zehl@univie.ac.at.",
            "firstname": "Martin",
            "initials": "M",
            "lastname": "Zehl"
        },
        {
            "affiliation": "Infectious Disease Laboratory-LADIC, Federal University of Parna\u00edba Delta-UFDPar, Campus Ministro Reis Velloso, S\u00e3o Benedito, Parna\u00edba 64202-020, Brazil. Electronic address: klinger@ufdpar.edu.br.",
            "firstname": "Klinger",
            "initials": "K",
            "lastname": "Antonio da Franca Rodrigues"
        },
        {
            "affiliation": "Fine Organic Chemistry Lab. Department of Chemistry and Biochemistry. Faculty of Science and Technology. University of Sao Paulo State (Unesp). Roberto Simonsen, 305 - 19060080. Presidente Prudente, Brazil. Electronic address: eduardo.gonzalez@unesp.br.",
            "firstname": "Eduardo Rene",
            "initials": "ER",
            "lastname": "Perez Gonzalez"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Masson SAS. All rights reserved.",
    "doi": "10.1016/j.ejmech.2025.117651",
    "journal": "European journal of medicinal chemistry",
    "keywords": [
        "Acridines",
        "Antileishmanial activity",
        "Guanidines",
        "Hybridization",
        "Leishmaniasis"
    ],
    "methods": null,
    "publication_date": "2025-04-28",
    "pubmed_id": "40288119",
    "results": null,
    "title": "Study of the antileishmanial activity of novel guanidine and hybrid acridine - guanidine compounds.",
    "xml": "<Element 'PubmedArticle' at 0x788503562b10>"
}