{
    "abstract": "Resistance to activated protein C is a common inherited risk factor for venous thrombosis, which is due to a mutation in coagulation factor V (factor V Leiden mutation). It is present in approximately 20% of unselected consecutive patients with deep vein thrombosis. The rate of resistance to activated protein C in patients with cerebral venous thrombosis (CVT) is unknown.\nWe investigated the association of factor V mutation with CVT using a case-control study. Nineteen unselected patients with CVT and 57 healthy control subjects were tested for the point mutation.\nThe mutation was found in a heterozygous form in 4 of the 19 patients with CVT (21%) and in only 1 of the 57 control subjects (2%) (P = .02, Fisher's exact test). The prevalence of the coagulation defect found in our patients with CVT was consistent with that observed in previous studies in patients with deep vein thrombosis. In 3 of the 4 patients positive for the mutation, CVT developed in the presence of an acquired prothrombotic state, including oral contraceptive use in 2 patients and puerperium in the third.\nFactor V Leiden mutation is a risk factor for CVT and may be the most common inherited coagulation defect associated with this condition.",
    "authors": [
        {
            "affiliation": "Service de Neurologie, Centre R. Garcin, H\u00f4pital Sainte-Anne, Paris, France.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Zuber"
        },
        {
            "affiliation": null,
            "firstname": "P",
            "initials": "P",
            "lastname": "Toulon"
        },
        {
            "affiliation": null,
            "firstname": "L",
            "initials": "L",
            "lastname": "Marnet"
        },
        {
            "affiliation": null,
            "firstname": "J L",
            "initials": "JL",
            "lastname": "Mas"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/01.str.27.10.1721",
    "journal": "Stroke",
    "keywords": [],
    "methods": null,
    "publication_date": "1996-10-01",
    "pubmed_id": "8841317",
    "results": "The mutation was found in a heterozygous form in 4 of the 19 patients with CVT (21%) and in only 1 of the 57 control subjects (2%) (P = .02, Fisher's exact test). The prevalence of the coagulation defect found in our patients with CVT was consistent with that observed in previous studies in patients with deep vein thrombosis. In 3 of the 4 patients positive for the mutation, CVT developed in the presence of an acquired prothrombotic state, including oral contraceptive use in 2 patients and puerperium in the third.",
    "title": "Factor V Leiden mutation in cerebral venous thrombosis.",
    "xml": "<Element 'PubmedArticle' at 0x7885065d0bd0>"
}