{
    "abstract": "Background Preeclampsia is a prominent risk factor for long-term development of cardiovascular disease. Although existing studies report a strong correlation between preeclampsia and heart failure, the underlying mechanisms are poorly understood. One possibility is the glycoprotein growth factor activin A. During pregnancy, elevated activin A levels are associated with impaired cardiac global longitudinal strain at 1 year, but whether these changes persist beyond 1 year is not known. We hypothesized that activin A levels would remain increased more than 1 year after a preeclamptic pregnancy and correlate with impaired cardiac function. Methods and Results To test our hypothesis, we performed echocardiograms and measured activin A levels in women approximately 10 years after an uncomplicated pregnancy (n=25) or a pregnancy complicated by preeclampsia (n=21). Compared with women with a previously normal pregnancy, women with preeclampsia had worse global longitudinal strain (-18.3% versus -21.3%, ",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Victoria A",
            "initials": "VA",
            "lastname": "deMartelly"
        },
        {
            "affiliation": "Department of Anesthesia and Critical Care University of Chicago IL.",
            "firstname": "John",
            "initials": "J",
            "lastname": "Dreixler"
        },
        {
            "affiliation": "Department of Anesthesia and Critical Care University of Chicago IL.",
            "firstname": "Avery",
            "initials": "A",
            "lastname": "Tung"
        },
        {
            "affiliation": "Department of Anesthesia Critical Care and Pain Medicine Massachusetts General HospitalHarvard Medical School Boston MA.",
            "firstname": "Ariel",
            "initials": "A",
            "lastname": "Mueller"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Sarah",
            "initials": "S",
            "lastname": "Heimberger"
        },
        {
            "affiliation": "Department of Anesthesia and Critical Care University of Chicago IL.",
            "firstname": "Abid A",
            "initials": "AA",
            "lastname": "Fazal"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Heba",
            "initials": "H",
            "lastname": "Naseem"
        },
        {
            "affiliation": "Department of Medicine University of Chicago IL.",
            "firstname": "Roberto",
            "initials": "R",
            "lastname": "Lang"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Eric",
            "initials": "E",
            "lastname": "Kruse"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Megan",
            "initials": "M",
            "lastname": "Yamat"
        },
        {
            "affiliation": "Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.",
            "firstname": "Joey P",
            "initials": "JP",
            "lastname": "Granger"
        },
        {
            "affiliation": "Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.",
            "firstname": "Bhavisha A",
            "initials": "BA",
            "lastname": "Bakrania"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Javier",
            "initials": "J",
            "lastname": "Rodriguez-Kovacs"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology University of Chicago IL.",
            "firstname": "Sarosh",
            "initials": "S",
            "lastname": "Rana"
        },
        {
            "affiliation": "Department of Anesthesia and Critical Care University of Chicago IL.",
            "firstname": "Sajid",
            "initials": "S",
            "lastname": "Shahul"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/JAHA.120.018526\n10.1161/CIRCOUTCOMES.116.003497\n10.1016/j.cytogfr.2013.03.003\n10.3109/10641955.2015.1090581\n10.1093/ije/19.2.284\n10.1136/bmj.j3078",
    "journal": "Journal of the American Heart Association",
    "keywords": [
        "cardiac dysfunction",
        "global longitudinal strain",
        "hypertension",
        "preeclampsia/pregnancy",
        "pregnancy and postpartum"
    ],
    "methods": null,
    "publication_date": "2021-02-24",
    "pubmed_id": "33619970\n24201165\n28228456\n31545680\n30577972\n28600845\n30842316\n31886717\n17332884\n21242811\n27477354\n21245136\n29844146\n29111424\n27113052\n25577185\n27628530\n30575675\n16376782\n25559473\n26403342\n23541927\n26636247\n21098311\n22891044\n23030711\n23190437\n32495688\n9153241\n26711734\n14993131\n14671202\n25555499\n17332518\n24147919\n30729712\n28710312\n29939936\n28330465\n2376438\n727205\n28701333\n21844489",
    "results": null,
    "title": "Long-Term Postpartum Cardiac Function and Its Association With Preeclampsia.",
    "xml": "<Element 'PubmedArticle' at 0x7885070e0680>"
}