{
    "abstract": "Del Nido cardioplegia (DNC) has been shown to be safe in adults with normal coronary arteries who are undergoing valve surgery. This study compared the effects of DNC versus traditional blood-based cardioplegia on postoperative complications in patients who underwent coronary artery bypass grafting (CABG).\nA retrospective analysis was performed on 863 patients who underwent CABG with DNC (n\u2009=\u2009420) or control cardioplegia (CC) (n\u2009=\u2009443) between 2014 and 2017. The full cohort of DNC and CC recipients, as well as propensity score-matched pairs, was compared regarding preoperative risk variables and outcomes.\nThe DNC and CC groups showed no significant differences in mean cardiopulmonary bypass time (53.09 vs 52.10\u2009min, P\u2009=\u20090.206) or aortic cross-clamp time (32.82 vs 33.28\u2009min, P\u2009=\u20090.967). The groups also showed no difference in operative mortality (2.1% vs 2.5%, P\u2009=\u20090.734); however, DNC use resulted in lower rates of overall infections (1.7% vs 4.3%, P\u2009=\u20090.024), total sternal infections (0.9% vs 3.2%, P\u2009=\u20090.023), postoperative atrial fibrillation (23.8% vs 30.7%, P\u2009=\u20090.023) and postoperative ventricular tachycardia (0.5% vs 3.4%, P\u2009=\u20090.002). A propensity-matching analysis (n\u2009=\u2009335 pairs) showed similar statistically significant decreases with DNC.\nIn this large cohort of CABG patients, DNC was shown as a safe alternative to CC and was associated with lower postoperative dysrhythmia and infection rates. These findings show that DNC is safe and effective in patients whose operative interventions may require only single-dosing cardioplegia; its use in longer cases should be further explored given its low complication rate.",
    "authors": [
        {
            "affiliation": "Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Alexander",
            "initials": "A",
            "lastname": "Schutz"
        },
        {
            "affiliation": "Surgical Research Core, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.",
            "firstname": "Qianzi",
            "initials": "Q",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Perfusion Technology, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Kimberly",
            "initials": "K",
            "lastname": "Bertapelle"
        },
        {
            "affiliation": "School of Perfusion Technology, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Nicholas",
            "initials": "N",
            "lastname": "Beecher"
        },
        {
            "affiliation": "School of Perfusion Technology, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "William",
            "initials": "W",
            "lastname": "Long"
        },
        {
            "affiliation": "Department of Biostatistics and Epidemiology, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Vei-Vei",
            "initials": "VV",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Cardiovascular Anesthesiology, Baylor College of Medicine/Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Pan"
        },
        {
            "affiliation": "School of Perfusion Technology, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Arcaro"
        },
        {
            "affiliation": "Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Ravi",
            "initials": "R",
            "lastname": "Ghanta"
        },
        {
            "affiliation": "Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Ernesto",
            "initials": "E",
            "lastname": "Jimenez"
        },
        {
            "affiliation": "Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "David A",
            "initials": "DA",
            "lastname": "Ott"
        },
        {
            "affiliation": "Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.\nDepartment of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.",
            "firstname": "Gabriel",
            "initials": "G",
            "lastname": "Loor"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.",
    "doi": "10.1093/icvts/ivaa010",
    "journal": "Interactive cardiovascular and thoracic surgery",
    "keywords": [
        "Atrial fibrillation",
        "Coronary artery disease",
        "Myocardial protection",
        "Postoperative complications"
    ],
    "methods": null,
    "publication_date": "2020-04-07",
    "pubmed_id": "32249892",
    "results": "The DNC and CC groups showed no significant differences in mean cardiopulmonary bypass time (53.09 vs 52.10\u2009min, P\u2009=\u20090.206) or aortic cross-clamp time (32.82 vs 33.28\u2009min, P\u2009=\u20090.967). The groups also showed no difference in operative mortality (2.1% vs 2.5%, P\u2009=\u20090.734); however, DNC use resulted in lower rates of overall infections (1.7% vs 4.3%, P\u2009=\u20090.024), total sternal infections (0.9% vs 3.2%, P\u2009=\u20090.023), postoperative atrial fibrillation (23.8% vs 30.7%, P\u2009=\u20090.023) and postoperative ventricular tachycardia (0.5% vs 3.4%, P\u2009=\u20090.002). A propensity-matching analysis (n\u2009=\u2009335 pairs) showed similar statistically significant decreases with DNC.",
    "title": "Del Nido cardioplegia in coronary surgery: a propensity-matched analysis.",
    "xml": "<Element 'PubmedArticle' at 0x7885025de430>"
}