{
    "abstract": "To avoid off-target effects, targeted cancer therapy offers a feasible alternative to traditional cancer therapies such as chemotherapy and radiotherapy. The human ferritin receptor (transferrin receptor, TfR1) is greatly overexpressed in several cancer types, including liver cancer. Therefore, human ferritin (HFn) has been used in drug encapsulation for targeted therapy. However, the drug encapsulation method is time-consuming and not applicable to all conditions. In this study, we effectively designed HFn fused with a photosensitizing protein called mini-singlet oxygen generator (miniSOG) to create HFn-miniSOG for targeted photodynamic therapy (PDT) applications. The fusion protein HFn-miniSOG self-assembled to form nanoparticles with an average size of 22.4 \u00b1 1.3 nm and generated singlet oxygen (",
    "authors": [
        {
            "affiliation": "School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.",
            "firstname": "Narathip",
            "initials": "N",
            "lastname": "Naradun"
        },
        {
            "affiliation": "School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.",
            "firstname": "Piyasiri",
            "initials": "P",
            "lastname": "Chueakwon"
        },
        {
            "affiliation": "School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.",
            "firstname": "Anyanee",
            "initials": "A",
            "lastname": "Kamkaew"
        },
        {
            "affiliation": "Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.",
            "firstname": "Kai-Yu",
            "initials": "KY",
            "lastname": "Hsu"
        },
        {
            "affiliation": "Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.",
            "firstname": "Man Nee",
            "initials": "MN",
            "lastname": "Lee"
        },
        {
            "affiliation": "National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani 12120, Thailand.",
            "firstname": "Kantapat",
            "initials": "K",
            "lastname": "Chansaenpak"
        },
        {
            "affiliation": "Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.\nInstitute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.",
            "firstname": "Yane-Shih",
            "initials": "YS",
            "lastname": "Wang"
        },
        {
            "affiliation": "School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.",
            "firstname": "Rung-Yi",
            "initials": "RY",
            "lastname": "Lai"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1021/acsabm.5c00098",
    "journal": "ACS applied bio materials",
    "keywords": [
        "ferritin",
        "miniSOG",
        "photodynamic therapy",
        "photosensitizer protein",
        "protein nanoparticles",
        "singlet oxygen",
        "transferrin receptor"
    ],
    "methods": null,
    "publication_date": "2025-04-22",
    "pubmed_id": "40260679",
    "results": null,
    "title": "Ferritin Fused with MiniSOG for ",
    "xml": "<Element 'PubmedArticle' at 0x788506659490>"
}