{
    "abstract": "The emergence of carbapenem-resistant Klebsiella pneumoniae presents significant health challenges. Here, we present the structural genome sequence of an NDM-5-producing K. pneumoniae (HZKP2) in China.\nAntimicrobial susceptibility tests were conducted via broth microdilution. Whole-genome sequencing was performed for genomic analysis. Wzi and capsular polysaccharide (KL) were analysed using Kaptive. Resistance genes, virulence factors, and comparative genomics analyses were also conducted. Multilocus sequence typing (MLST), replicons type, and core genome MLST analysis were further conducted using BacWGSTdb server.\nHZKP2 was resistant to cefepime, ceftazidime, ciprofloxacin, ciprofloxacin, meropenem, and ertapenem. It harboured fosA, bla\nOur study provides the first structural perspective of the ST1 K. pneumoniae isolate producing NDM-5 in China. These results could provide valuable insights into the genetic characteristics, antimicrobial resistance mechanisms, and transmission dynamics of carbapenem-resistant K. pneumoniae in clinical settings.",
    "authors": [
        {
            "affiliation": "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.",
            "firstname": "Xuebin",
            "initials": "X",
            "lastname": "Tian"
        },
        {
            "affiliation": "School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.",
            "firstname": "Lu",
            "initials": "L",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Archives, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.",
            "firstname": "Chun",
            "initials": "C",
            "lastname": "Li"
        },
        {
            "affiliation": "School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.",
            "firstname": "Daozong",
            "initials": "D",
            "lastname": "Xia"
        },
        {
            "affiliation": "Department of Urology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China. Electronic address: 652868133@qq.com.",
            "firstname": "Junjie",
            "initials": "J",
            "lastname": "Ying"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024. Published by Elsevier Ltd.",
    "doi": "10.1016/j.jgar.2024.05.001",
    "journal": "Journal of global antimicrobial resistance",
    "keywords": [
        "Carbapenem-resistant Klebsiella pneumoniae",
        "Phylogenetics",
        "Whole-genome sequencing",
        "bla(NDM-5)"
    ],
    "methods": null,
    "publication_date": "2024-05-25",
    "pubmed_id": "38789084",
    "results": "HZKP2 was resistant to cefepime, ceftazidime, ciprofloxacin, ciprofloxacin, meropenem, and ertapenem. It harboured fosA, bla",
    "title": "Genome sequence of a sequence type 1 NDM-5-producing carbapenem-resistant Klebsiella pneumoniae in China.",
    "xml": "<Element 'PubmedArticle' at 0x788504118310>"
}