{
    "abstract": "The diastolic pressure difference (DPD) is recommended to differentiate between isolated postcapillary and combined pre-/postcapillary pulmonary hypertension (Cpc-PH) in left heart disease (PH-LHD). However, in usual practice, negative DPD values are commonly calculated, potentially related to the use of mean pulmonary artery wedge pressure (PAWP). We used the ECG to gate late-diastolic PAWP measurements. We examined the method's impact on calculated DPD, PH-LHD subclassification, hemodynamic profiles, and mortality.\nWe studied patients with advanced heart failure undergoing right heart catheterization to assess cardiac transplantation candidacy (N=141). Pressure tracings were analyzed offline over 8 to 10 beat intervals. Diastolic pulmonary artery pressure and mean PAWP were measured to calculate the DPD as per usual practice (diastolic pulmonary artery pressure-mean PAWP). Within the same intervals, PAWP was measured gated to the ECG QRS complex to calculate the QRS-gated DPD (diastolic pulmonary artery pressure-QRS-gated PAWP). Outcomes occurring within 1 year were collected retrospectively from chart review. Overall, 72 of 141 cases demonstrated PH-LHD. Within PH-LHD, the QRS-gated DPD yielded higher calculated DPD values (3 [-1 to 6] versus 0 [-4 to 3] mm\u2009Hg; \nThe DPD calculated in usual practice is underestimated in PH-LHD, which may classify Cpc-PH patients as isolated postcapillary pulmonary hypertension. The QRS-gated DPD reclassifies a subset of PH-LHD patients from isolated postcapillary pulmonary hypertension to Cpc-PH, which is characterized by an adverse hemodynamic profile.",
    "authors": [
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Stephen P",
            "initials": "SP",
            "lastname": "Wright"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Yasbanoo",
            "initials": "Y",
            "lastname": "Moayedi"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Farid",
            "initials": "F",
            "lastname": "Foroutan"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Suhail",
            "initials": "S",
            "lastname": "Agarwal"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Geraldine",
            "initials": "G",
            "lastname": "Paradero"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Ana C",
            "initials": "AC",
            "lastname": "Alba"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.).",
            "firstname": "Jay",
            "initials": "J",
            "lastname": "Baumwol"
        },
        {
            "affiliation": "From the Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada (S.P.W., S.M.); Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada (S.P.W., Y.M., F.F., S.A., G.P., A.C.A., S.M.); and Advanced Heart Failure and Cardiac Transplant Service, Division of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia (J.B.). susanna.mak@sinaihealthsystem.ca.",
            "firstname": "Susanna",
            "initials": "S",
            "lastname": "Mak"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2017 American Heart Association, Inc.",
    "doi": "10.1161/CIRCHEARTFAILURE.117.004077",
    "journal": "Circulation. Heart failure",
    "keywords": [
        "blood pressure",
        "heart failure",
        "hemodynamics",
        "hypertension, pulmonary",
        "transplants"
    ],
    "methods": null,
    "publication_date": "2017-09-16",
    "pubmed_id": "28912262",
    "results": null,
    "title": "Diastolic Pressure Difference to Classify Pulmonary Hypertension in the Assessment of Heart Transplant Candidates.",
    "xml": "<Element 'PubmedArticle' at 0x788506663ec0>"
}