{
    "abstract": "To assess the manifestations of cerebral venous thrombosis (CVT) associated with intracranial hypotension (IH) following lumbar puncture (LP) or spinal anesthesia (SA).\nAdult patients with acute CVT unrelated to infection, neurosurgery, or otolaryngological surgery were identified. CVT manifesting within 21days after LP/SA was considered associated with iatrogenic IH. Presentation of patients with and without associate IH was compared.\n42 patients were included. 11/42 who had undergone LP/SA presented symptoms and imaging characteristics of IH; 31 had no evidence of IH. Those with IH were more often females (11/11 vs. 21/31, p=0.03), presented sooner after symptom onset (6.0\u00b12.2 vs. 15.6\u00b114days, p=0.002), and rates of venous infarction (45% vs. 23%) and seizures (27% vs. 10%) appeared somewhat elevated (p<0.15). Patients with CVT associated with IH had significantly more cortical vein thrombi (55% vs. 16%, p=0.02). Thrombi were significantly shorter in patients with IH (102\u00b1113mm vs. 246\u00b1133mm, p=0.002).\nPatients with CVT secondary to IH were typically younger females, and presented with a more acute and severe course with frequent venous infarcts. Although thrombi in the IH group were less extensive, they were more often symptomatic.",
    "authors": [
        {
            "affiliation": "Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: Asaf.honig2@gmail.com.",
            "firstname": "Asaf",
            "initials": "A",
            "lastname": "Honig"
        },
        {
            "affiliation": "Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.",
            "firstname": "Ruth",
            "initials": "R",
            "lastname": "Eliahou"
        },
        {
            "affiliation": "Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.",
            "firstname": "Y Y",
            "initials": "YY",
            "lastname": "Pikkel"
        },
        {
            "affiliation": "Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.",
            "firstname": "Ronen R",
            "initials": "RR",
            "lastname": "Leker"
        }
    ],
    "conclusions": "Patients with CVT secondary to IH were typically younger females, and presented with a more acute and severe course with frequent venous infarcts. Although thrombi in the IH group were less extensive, they were more often symptomatic.",
    "copyrights": "Copyright \u00a9 2016 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jns.2016.05.009",
    "journal": "Journal of the neurological sciences",
    "keywords": [
        "Cerebral venous thrombosis",
        "Dural puncture",
        "Iatrogenic",
        "Intracranial hypotension",
        "Spinal anesthesia",
        "Stroke"
    ],
    "methods": null,
    "publication_date": "2016-06-12",
    "pubmed_id": "27288804",
    "results": "42 patients were included. 11/42 who had undergone LP/SA presented symptoms and imaging characteristics of IH; 31 had no evidence of IH. Those with IH were more often females (11/11 vs. 21/31, p=0.03), presented sooner after symptom onset (6.0\u00b12.2 vs. 15.6\u00b114days, p=0.002), and rates of venous infarction (45% vs. 23%) and seizures (27% vs. 10%) appeared somewhat elevated (p<0.15). Patients with CVT associated with IH had significantly more cortical vein thrombi (55% vs. 16%, p=0.02). Thrombi were significantly shorter in patients with IH (102\u00b1113mm vs. 246\u00b1133mm, p=0.002).",
    "title": "Iatrogenic intracranial hypotension and cerebral venous thrombosis.",
    "xml": "<Element 'PubmedArticle' at 0x7885046cb0b0>"
}