{
    "abstract": "The therapeutic effects of steroids in immunoglobulin A nephropathy (IgAN) global (TESTING) study reported that methylprednisolone reduces the risk of major kidney events in individuals with IgAN at high risk of disease progression compared to supportive care alone but is associated with increased serious adverse events (SAEs) primarily with full-dose therapy. The risk benefit balance of the reduced-dose methylprednisolone regimen is examined in this prespecified analysis of the reduced-dose cohort of the TESTING trial.\nBetween 2017 and 2019, patients with IgAN, proteinuria\u00a0\u22651 g/d despite 3 months of renin-angiotensin-system blockade and estimated glomerular filtration rate (eGFR) 30 to 120 ml/min per 1.73 m\nA total of 241 participants were randomized and followed-up with for a median of 2.5 years (mean age: 37 years; baseline eGFR: 65 ml/min per 1.73 m\nReduced-dose methylprednisolone is effective in improving kidney outcomes in high risk IgAN; however, it is associated with a modestly higher number of SAEs compared to placebo.",
    "authors": [
        {
            "affiliation": "The George Institute for Global Health, University of New South Wales, Sydney, Australia.\nFaculty of Medicine and Health, The University of Sydney, Sydney, Australia.",
            "firstname": "Dana",
            "initials": "D",
            "lastname": "Kim"
        },
        {
            "affiliation": "Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.",
            "firstname": "Jicheng",
            "initials": "J",
            "lastname": "Lv"
        },
        {
            "affiliation": "Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada.",
            "firstname": "Michelle",
            "initials": "M",
            "lastname": "Hladunewich"
        },
        {
            "affiliation": "The George Institute for Global Health India, UNSW, New Delhi, India.\nPrasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India.\nThe George Institute for Global Health, School of Public Health, Imperial College London, UK.",
            "firstname": "Vivekanand",
            "initials": "V",
            "lastname": "Jha"
        },
        {
            "affiliation": "Sultanah Aminah Hospital, Johor Bahru, Malaysia.",
            "firstname": "Lai Seong",
            "initials": "LS",
            "lastname": "Hooi"
        },
        {
            "affiliation": "The George Institute for Global Health, University of New South Wales, Sydney, Australia.",
            "firstname": "Helen",
            "initials": "H",
            "lastname": "Monaghan"
        },
        {
            "affiliation": "The George Institute for Global Health, University of New South Wales, Sydney, Australia.",
            "firstname": "Sana",
            "initials": "S",
            "lastname": "Shan"
        },
        {
            "affiliation": "Division of Nephrology, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.",
            "firstname": "Heather N",
            "initials": "HN",
            "lastname": "Reich"
        },
        {
            "affiliation": "Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada.",
            "firstname": "Sean",
            "initials": "S",
            "lastname": "Barbour"
        },
        {
            "affiliation": "The George Institute for Global Health, University of New South Wales, Sydney, Australia.",
            "firstname": "Laurent",
            "initials": "L",
            "lastname": "Billot"
        },
        {
            "affiliation": "Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.",
            "firstname": "Hong",
            "initials": "H",
            "lastname": "Zhang"
        },
        {
            "affiliation": "The George Institute for Global Health, University of New South Wales, Sydney, Australia.",
            "firstname": "Vlado",
            "initials": "V",
            "lastname": "Perkovic"
        },
        {
            "affiliation": "The George Institute for Global Health, University of New South Wales, Sydney, Australia.\nFaculty of Medicine and Health, The University of Sydney, Sydney, Australia.\nDepartment of Renal Medicine, Concord Repatriation General Hospital, Australia.",
            "firstname": "Muh Geot",
            "initials": "MG",
            "lastname": "Wong"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": "Reduced-dose methylprednisolone is effective in improving kidney outcomes in high risk IgAN; however, it is associated with a modestly higher number of SAEs compared to placebo.",
    "copyrights": "\u00a9 2024 International Society of Nephrology. Published by Elsevier Inc.",
    "doi": "10.1016/j.ekir.2024.03.032\n10.1371/journal.pone.0091756\n10.2215/cjn.0000000000000135\n10.1681/asn.2011050464\n10.1016/j.kint.2021.05.021\n10.1001/jama.2022.5368\n10.1001/jama.2017.9362\n10.1159/000519812\n10.1016/j.kint.2017.02.003\n10.1097/01.asn.0000103869.08096.4f\n10.1016/s0272-6386(03)00194-x\n10.1053/j.ajkd.2008.07.029\n10.1093/ndt/gfp356\n10.1056/NEJMoa1415463\n10.1681/asn.2011111112\n10.1056/NEJMoa2305635\n10.1016/j.ekir.2022.12.014\n10.1080/0886022X.2022.2048017\n10.2215/cjn.08600718\n10.1053/j.ajkd.2021.03.007\n10.1016/S0140-6736(17)30550-0\n10.1016/j.kint.2022.09.017\n10.1016/S0140-6736(23)01554-4\n10.1016/j.kint.2021.03.033\n10.1016/s0140-6736(23)02302-4\n10.1038/ki.2013.210",
    "journal": "Kidney international reports",
    "keywords": [
        "IgA nephropathy",
        "corticosteroids",
        "glomerulonephritis"
    ],
    "methods": null,
    "publication_date": "2024-07-31",
    "pubmed_id": "39081761\n3329736\n24658533\n37055195\n21949093\n34556256\n35579642\n28763548\n34731857\n28341274\n14694168\n12722031\n18930568\n19628647\n26630142\n22539830\n37916620\n36938094\n35272573\n30635299\n33775708\n28363480\n36270561\n37591292\n33878338\n37931634\n23739233",
    "results": "A total of 241 participants were randomized and followed-up with for a median of 2.5 years (mean age: 37 years; baseline eGFR: 65 ml/min per 1.73 m",
    "title": "The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy.",
    "xml": "<Element 'PubmedArticle' at 0x788504606520>"
}