{
    "abstract": "(1) To assess variations of the human intracochlear anatomy and quantify factors which might be relevant for cochlear implantation (CI) regarding surgical technique and electrode design. (2) Search for correlations of these factors with clinically assessable measurements.\nHuman temporal bone study with micro computed tomography (\u03bcCT) data and analysis of intracochlear geometrical variations: \u03bcCT data of 15 fresh human temporal bones was generated, and the intracochlear lumina scala tympani (ST) and scala vestibuli were manually segmented using custom software specifically designed for accurate cochlear segmentation. The corresponding datasets were processed yielding 15 detailed, three-dimensional cochlear models which were investigated in terms of the scalae height, cross-sectional size, and rotation as well as the interrelation of these factors and correlations to others.\nThe greatest anatomical variability was observed within the round window region of the cochlea (basal 45\u00b0), especially regarding the cross-sectional size of the ST and its orientation relative to the scala vestibuli, which were found to be correlated (p < 0.001). The cross-sectional height of the ST changes substantially for both increasing cochlear angles and lateral wall distances. Even small cochleae were found to contain enough space for all commercially available CI arrays. Significant correlations of individual intracochlear parameters to clinically assessable ones were found despite the small sample size.\nWhile there is generally enough space within the ST for CI, strong intracochlear anatomical variations could be observed highlighting the relevance of both soft surgical technique as well as a highly flexible and self-adapting cochlear implant electrode array design. Cochlear dimensions (especially at the round window) could potentially be used to indicate surgically challenging anatomies.",
    "authors": [
        {
            "affiliation": "MED-EL Medical Electronics, Hannover Research Center, Hannover, Germany.",
            "firstname": "Daniel",
            "initials": "D",
            "lastname": "Schurzig"
        },
        {
            "affiliation": "Cluster of Excellence Hearing4all, Dept. of Otolaryngology, Hannover Medical School, Hannover, Germany.",
            "firstname": "Max E",
            "initials": "ME",
            "lastname": "Timm"
        },
        {
            "affiliation": "Cluster of Excellence Hearing4all, Dept. of Otolaryngology, Hannover Medical School, Hannover, Germany.",
            "firstname": "Omid",
            "initials": "O",
            "lastname": "Majdani"
        },
        {
            "affiliation": "Cluster of Excellence Hearing4all, Dept. of Otolaryngology, Hannover Medical School, Hannover, Germany.",
            "firstname": "Thomas",
            "initials": "T",
            "lastname": "Lenarz"
        },
        {
            "affiliation": "Cluster of Excellence Hearing4all, Dept. of Otolaryngology, Hannover Medical School, Hannover, Germany.",
            "firstname": "Thomas S",
            "initials": "TS",
            "lastname": "Rau"
        }
    ],
    "conclusions": "While there is generally enough space within the ST for CI, strong intracochlear anatomical variations could be observed highlighting the relevance of both soft surgical technique as well as a highly flexible and self-adapting cochlear implant electrode array design. Cochlear dimensions (especially at the round window) could potentially be used to indicate surgically challenging anatomies.",
    "copyrights": "Copyright \u00a9 2021 Wolters Kluwer Health, Inc. All rights reserved.",
    "doi": "10.1097/AUD.0000000000000998\n10.1097/MAO.0000000000002880",
    "journal": "Ear and hearing",
    "keywords": [],
    "methods": null,
    "publication_date": "2021-01-23",
    "pubmed_id": "33480625",
    "results": "The greatest anatomical variability was observed within the round window region of the cochlea (basal 45\u00b0), especially regarding the cross-sectional size of the ST and its orientation relative to the scala vestibuli, which were found to be correlated (p < 0.001). The cross-sectional height of the ST changes substantially for both increasing cochlear angles and lateral wall distances. Even small cochleae were found to contain enough space for all commercially available CI arrays. Significant correlations of individual intracochlear parameters to clinically assessable ones were found despite the small sample size.",
    "title": "The Use of Clinically Measurable Cochlear Parameters in Cochlear Implant Surgery as Indicators for Size, Shape, and Orientation of the Scala Tympani.",
    "xml": "<Element 'PubmedArticle' at 0x7885048ef1a0>"
}