{
    "abstract": "In this report, the clinical performance of Liferiver HarmoniaHPV and Liferiver VenusHPV was evaluated under the VALHUDES framework. Five hundred and twenty-three\u00a0women collected first-void urine (FVU) with Colli-Pee and vaginal samples with Evalyn Brush or Qvintip. Cervical samples were taken with the Cervex Brush by a clinician. Both vaginal and cervical samples were resuspended in 20\u2009mL ThinPrep. Triplet samples from 499 women were tested with HarmoniaHPV and VenusHPV tests. The clinical accuracy of HarmoniaHPV did not differ in FVU and vaginal self-samples versus cervical samples. The relative sensitivity for CIN2+ on FVU and vaginal samples was 0.95 [95% CI 0.89-1.02] and 0.95 [95% CI 0.88-1.02], respectively. Relative specificity for <\u2009CIN2 was 0.95 [0.86-1.04] on FVU and 0.93 [0.86-1.01] on vaginal samples. VenusHPV demonstrated lower sensitivity on both self-sample types, whereas the specificity was similar to cervical samples. Post-hoc adjustment of the VenusHPV C",
    "authors": [
        {
            "affiliation": "Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, Brussels, Belgium.",
            "firstname": "Ardashel",
            "initials": "A",
            "lastname": "Latsuzbaia"
        },
        {
            "affiliation": "Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Edegem, Antwerp, Belgium.",
            "firstname": "Severien",
            "initials": "S",
            "lastname": "Van Keer"
        },
        {
            "affiliation": "Laboratory of Molecular Pathology, AML Sonic Healthcare, Antwerp, Belgium.\nNational Reference Centre for HPV, Brussels, Belgium.\nAMBIOR, Laboratory for Cell Biology & Histology, University of Antwerp, Antwerp, Belgium.\nInternational Centre for Reproductive Health, Ghent University, Ghent, Belgium.",
            "firstname": "Davy Vanden",
            "initials": "DV",
            "lastname": "Broeck"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium.",
            "firstname": "Steven",
            "initials": "S",
            "lastname": "Weyers"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology of the General Regional Hospital Heilig Hart, Tienen, Belgium.\nFemicare vzw, Clinical Research for Women, Tienen.\nDepartment of Obstetrics and Gynaecology University Hospital Antwerp, Antwerp, Belgium.",
            "firstname": "Gilbert",
            "initials": "G",
            "lastname": "Donders"
        },
        {
            "affiliation": "Department Gynaecology-Oncology, UZ Brussel-VUB, Brussels, Belgium.",
            "firstname": "Philippe",
            "initials": "P",
            "lastname": "De Sutter"
        },
        {
            "affiliation": "Multidisciplinary Breast Clinic, Unit Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Antwerp University Hospital (UZA), Edegem, Belgium.\nMolecular Imaging, Pathology, Radiotherapy, Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.",
            "firstname": "Wiebren",
            "initials": "W",
            "lastname": "Tjalma"
        },
        {
            "affiliation": "Department Gynaecology-Obstetrics, University Hospital Li\u00e8ge, Li\u00e8ge, Belgium.",
            "firstname": "Jean",
            "initials": "J",
            "lastname": "Doyen"
        },
        {
            "affiliation": "International Centre for Reproductive Health, Ghent University, Ghent, Belgium.",
            "firstname": "Alex",
            "initials": "A",
            "lastname": "Vorsters"
        },
        {
            "affiliation": "Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, Brussels, Belgium.\nDepartment of Human Structure and Repair, Faculty of Medicine and Health Sciences, University Ghent, Ghent, Belgium.",
            "firstname": "Marc",
            "initials": "M",
            "lastname": "Arbyn"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.",
    "doi": "10.1002/jmv.70273\n10.1002/14651858.CD008587.pub2",
    "journal": "Journal of medical virology",
    "keywords": [
        "HPV",
        "VALHUDES",
        "cervical cancer screening",
        "diagnostic test accuracy",
        "self\u2010sampling"
    ],
    "methods": null,
    "publication_date": "2025-03-03",
    "pubmed_id": "40028694\n31812369\n28796882\n31539637\n35839811\n30518635\n26296294\n34861338\n24433684\n30195193\n33895238\n28137831\n36047900\n34172287\n26522865\n33975008\n39097395\n39486311\n39588720\n37354994\n37865293\n36049283\n36099441\n35243475\n36655599\n36647333\n38323823\n20039323\n38922964\n35690793",
    "results": null,
    "title": "Accuracy of Liferiver HarmoniaHPV and VenusHPV Assays on Urine and Vaginal Self-Samples.",
    "xml": "<Element 'PubmedArticle' at 0x788506237e70>"
}