{
    "abstract": "Intraperitoneal antibiotics may be required daily for up to three weeks to treat peritoneal dialysis (PD)-related peritonitis. In some jurisdictions, antibiotic-admixed PD solutions are required to be used within 24 h due to concerns regarding microbial contamination and growth. This requires patients to attend the PD unit daily or alternatively for staff to perform home delivery with associated transport, staffing and cost implications.\nThe aim of this study was to determine if significant microbial growth occurs in PD solutions following their injection with antibiotic or sterile water.\nTwelve PD solution bags were admixed with cefazolin sodium 1 g, diluted in 10 mL sterile water, while a further 12 PD solution bags were admixed with 10 mL sterile water using aseptic technique (AT) under supervision. All bags were stored at room temperature. Three bags from each experimental group were sampled for microbiologic culture at 0-, 24-, 48- and 72-h intervals.\nOne sterile water admixed bag sampled at 24 h yielded a \nAntibiotic-admixed PD solutions prepared using AT and stored at room temperature remained sterile for up to 72 h. This suggests that patients can be safely issued with a supply of antibiotic-admixed PD bags for up to three days at a time.",
    "authors": [
        {
            "affiliation": "Department of Kidney services, Logan hospital, Meadowbrook, QLD, Australia.\nSchool of Medicine, University of Queensland, Australia.\nSchool of Medicine, Griffith University, QLD, Australia.",
            "firstname": "Ken-Soon",
            "initials": "KS",
            "lastname": "Tan"
        },
        {
            "affiliation": "Department of Kidney services, Logan hospital, Meadowbrook, QLD, Australia.",
            "firstname": "Robyn",
            "initials": "R",
            "lastname": "Rogers"
        },
        {
            "affiliation": "Department of Kidney services, Logan hospital, Meadowbrook, QLD, Australia.",
            "firstname": "Deanna",
            "initials": "D",
            "lastname": "Shephard"
        },
        {
            "affiliation": "Department of Kidney services, Logan hospital, Meadowbrook, QLD, Australia.",
            "firstname": "Amanda",
            "initials": "A",
            "lastname": "Lewis"
        },
        {
            "affiliation": "Department of Microbiology, Royal Brisbane and Women's hospital, Herston, QLD, Australia.",
            "firstname": "Narelle",
            "initials": "N",
            "lastname": "George"
        },
        {
            "affiliation": "School of Medicine, University of Queensland, Australia.\nDepartment of Kidney and Transplant services, Princess Alexandra hospital, Woolloongabba, QLD, Australia.",
            "firstname": "David W",
            "initials": "DW",
            "lastname": "Johnson"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1177/08968608231213736",
    "journal": "Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis",
    "keywords": [
        "Anti-bacterial agents",
        "antibiotics",
        "comparative study",
        "dialysis solutions",
        "drug contamination",
        "intraperitoneal",
        "microbiological techniques",
        "peritoneal dialysis",
        "peritonitis",
        "sterilisation"
    ],
    "methods": null,
    "publication_date": "2023-12-20",
    "pubmed_id": "38115707",
    "results": "One sterile water admixed bag sampled at 24 h yielded a ",
    "title": "Sterility of antibiotic-admixed peritoneal dialysis solution over time.",
    "xml": "<Element 'PubmedArticle' at 0x7885044b4a40>"
}