{
    "abstract": "Our objective was to estimate the association between in vitro fertilization (IVF) pregnancy and adverse pregnancy outcomes during delivery hospital admission in a contemporary, nation-wide cohort of births in the United States.\nThis retrospective, population-based cohort study used the National Inpatient Sample database to identify patients discharged from the hospital following delivery from 2014 to 2019. IVF pregnancies were identified using the International Classification of Disease-Revision 9/10 codes. Crude and adjusted odds ratios of preterm birth and other clinically significant adverse pregnancy outcomes were evaluated using multivariable logistic regression models. Trends in preterm birth and multiple pregnancy were estimated over the study period. The contribution of multiple pregnancy to preterm birth in IVF pregnancy was estimated in a mediation analysis.\nAmong 4,451,667 delivery-related discharges, IVF pregnancies were associated with 3.25 times the odds of preterm birth (95% confidence interval [CI]: 3.05-3.46, \nWhile the odds of adverse pregnancy outcomes are increased compared with non-IVF pregnancies, the odds of preterm birth and multiple gestation have decreased among IVF pregnancies in the United States.\n\u00b7 Pregnancies conceived by in vitro fertilization (IVF) are at significantly higher risk of multiple gestation, preterm birth, and other pregnancy complications.. \u00b7 Recent guidelines for artificial reproductive treatments recommend single-embryo transfer in IVF.. \u00b7 Using population-wide data, we demonstrate a significant gradual decline in the rates of preterm birth and other pregnancy complications following IVF in the last decade, mostly mediated by a reduction in multiple pregnancies..",
    "authors": [
        {
            "affiliation": "Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.\nDepartment of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, Canada.\nDepartment of Obstetrics and Gynecology, Dalhousie University, Halifax, Canada.",
            "firstname": "Jocelyn",
            "initials": "J",
            "lastname": "Stairs"
        },
        {
            "affiliation": "Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.",
            "firstname": "Tina Y J",
            "initials": "TYJ",
            "lastname": "Hsieh"
        },
        {
            "affiliation": "Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.\nDepartment of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.",
            "firstname": "Daniel L",
            "initials": "DL",
            "lastname": "Rolnik"
        }
    ],
    "conclusions": "While the odds of adverse pregnancy outcomes are increased compared with non-IVF pregnancies, the odds of preterm birth and multiple gestation have decreased among IVF pregnancies in the United States.",
    "copyrights": "Thieme. All rights reserved.",
    "doi": "10.1055/a-1979-8250",
    "journal": "American journal of perinatology",
    "keywords": [],
    "methods": null,
    "publication_date": "2022-11-18",
    "pubmed_id": "36384238",
    "results": "Among 4,451,667 delivery-related discharges, IVF pregnancies were associated with 3.25 times the odds of preterm birth (95% confidence interval [CI]: 3.05-3.46, ",
    "title": "In Vitro Fertilization and Adverse Pregnancy Outcomes in the Elective Single Embryo Transfer Era.",
    "xml": "<Element 'PubmedArticle' at 0x7885038f3330>"
}