{
    "abstract": "To find a useful hypoxia non-invasive biomarker for evaluating early treatment response and prognosis to definitive chemoradiotherapy (dCRT) in patients with esophageal squamous cell carcinoma (ESCC), using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).\nThe R2* values were obtained pre- and 2-3 weeks post-dCRT in 28 patients with ESCC using BOLD MRI. Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare the differences of R2*-related parameters between the complete response (CR) and the non-CR groups. Diagnostic performance of parameters in predicting response was tested with receiver operating characteristic (ROC) curve analysis. The 3-year overall survival (OS) was evaluated using Kaplan Meier curve, log rank test, and Cox proportional hazards regression analysis.\nThe post-R2*, \u2206R2*, and \u2206%R2* in the CR group were significantly higher than those in the non-CR group (P\u2009=\u20090.002, 0.003, and 0.006, respectively). The R2*-related parameters showed good prediction of tumor response, with AUC ranging from 0.813 to 0.829. The 3-year OS rate in patients with \u2206R2* >-7.54\u00a0s\nThe preliminary results demonstrated that the R2* value might be a useful hypoxia non-invasive biomarker for assessing response and prognosis of ESCC treated with dCRT. BOLD MRI might be used as a potential tool for evaluating tumor oxygenation metabolism, which is routinely applied in clinical practice and beneficial to clinical decision-making. A large sample size was needed for further follow-up studies to confirm the findings.",
    "authors": [
        {
            "affiliation": "Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, China.",
            "firstname": "Huanhuan",
            "initials": "H",
            "lastname": "Zheng"
        },
        {
            "affiliation": "Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, China.",
            "firstname": "Hailong",
            "initials": "H",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, China.",
            "firstname": "Yan",
            "initials": "Y",
            "lastname": "Zhu"
        },
        {
            "affiliation": "Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, China.",
            "firstname": "Xiaolei",
            "initials": "X",
            "lastname": "Wei"
        },
        {
            "affiliation": "Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, China. liusongnj@126.com.",
            "firstname": "Song",
            "initials": "S",
            "lastname": "Liu"
        },
        {
            "affiliation": "The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, 210008, China. renwei@njglyy.com.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Ren"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s12880-024-01193-9\n10.3322/caac.21660\n10.2188/jea.JE20120162\n10.1093/annonc/mds206\n10.1200/JCO.2005.04.7118\n10.4161/cbt.9.12.12347\n10.1111/j.1442-2050.2011.01209.x\n10.1148/radiol.14140654\n10.1186/s12880-022-00791-9\n10.1148/radiol.2021203568\n10.21037/qims.2019.10.20\n10.1016/j.ejrad.2021.109995\n10.1148/radiol.2017161998\n10.1186/s12880-021-00675-4\n10.1016/j.rcl.2019.07.006\n10.1016/j.mri.2020.10.008\n10.1007/s00330-017-4832-x\n10.3389/fonc.2021.670156\n10.1038/sj.bjc.6604903\n10.1007/s00330-014-3167-0\n10.1007/s00330-019-06198-5\n10.1148/radiol.10100421\n10.3348/kjr.2017.18.4.674\n10.1016/j.ejro.2016.06.003\n10.1158/1078-0432.CCR-04-0713\n10.3389/fcell.2019.00004\n10.1002/jmri.24837",
    "journal": "BMC medical imaging",
    "keywords": [
        "Blood oxygenation level-dependent",
        "Chemoradiotherapy",
        "Esophageal neoplasms",
        "Prognosis",
        "Response"
    ],
    "methods": null,
    "publication_date": "2024-01-13",
    "pubmed_id": "38216885\n33538338\n23629646\n22887465\n17401004\n27774485\n20581454\n21595781\n25423146\n35366813\n33687287\n31956534\n34628310\n28777704\n34583652\n31582044\n33080334\n28401339\n34109120\n19190629\n24763631\n31016443\n20858850\n28670162\n27489868\n15534099\n30761299\n30091709\n25581675",
    "results": "The post-R2*, \u2206R2*, and \u2206%R2* in the CR group were significantly higher than those in the non-CR group (P\u2009=\u20090.002, 0.003, and 0.006, respectively). The R2*-related parameters showed good prediction of tumor response, with AUC ranging from 0.813 to 0.829. The 3-year OS rate in patients with \u2206R2* >-7.54\u00a0s",
    "title": "Value of blood oxygenation level-dependent magnetic resonance imaging in early evaluation of the response and prognosis of esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: a preliminary study.",
    "xml": "<Element 'PubmedArticle' at 0x788502c53b00>"
}