{
    "abstract": "A 36-year-old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116\u2009mmHg and retinal, cardiac, and brain damage revealed by electrocardiogram, fundoscopy, and magnetic resonance imaging, respectively. Although hemodialysis was withdrawn following strict blood pressure control by an angiotensin receptor blocker, severe kidney insufficiency persisted. Therefore, we performed an autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34-positive cell transplantation. Collected CD34-positive cells were directly infused to both renal arteries. The patient's general condition was unremarkable after intervention, and the serum creatinine level gradually improved to 2.96\u2009mg/dL 23\u2009weeks after cell therapy. Although transient fever and thrombocytosis were observed after intervention, no major adverse events were observed. This patient is the first case in a phase I/II clinical trial of autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34-positive cell transplantation for severe AKI with a CD34-positive cell dose-escalating protocol (trial number jRCTb030190231).",
    "authors": [
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Hiroyuki",
            "initials": "H",
            "lastname": "Suzuki"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Takayasu",
            "initials": "T",
            "lastname": "Ohtake"
        },
        {
            "affiliation": "Department of Radiology and Interventional Radiology, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Toshitaka",
            "initials": "T",
            "lastname": "Tsukiyama"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Marie",
            "initials": "M",
            "lastname": "Morota"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Kunihiro",
            "initials": "K",
            "lastname": "Ishioka"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Hidekazu",
            "initials": "H",
            "lastname": "Moriya"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Yasuhiro",
            "initials": "Y",
            "lastname": "Mochida"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Sumi",
            "initials": "S",
            "lastname": "Hidaka"
        },
        {
            "affiliation": "Clinical Laboratory, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Tsutomu",
            "initials": "T",
            "lastname": "Sato"
        },
        {
            "affiliation": "Regenerative Medicine Science, Tokai University School of Medicine, Isehara, Japan.",
            "firstname": "Takayuki",
            "initials": "T",
            "lastname": "Asahara"
        },
        {
            "affiliation": "Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.",
            "firstname": "Shuzo",
            "initials": "S",
            "lastname": "Kobayashi"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2021 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.",
    "doi": "10.1002/sctm.20-0561",
    "journal": "Stem cells translational medicine",
    "keywords": [
        "CD34+",
        "clinical trials",
        "granulocyte-colony stimulating factor (G-CSF)",
        "hematopoietic stem cells (HSCs)",
        "kidney",
        "stem cell transplantation"
    ],
    "methods": null,
    "publication_date": "2021-05-07",
    "pubmed_id": "33955678\n16106006\n29737200\n21092414\n20049901\n26565621\n19711453\n24731186\n9020076\n16410390\n24835991\n25536864\n27986662\n30059194\n17562958\n25107583\n33012343\n30842365\n24257136\n32297703",
    "results": null,
    "title": "Acute kidney injury successfully treated with autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34-positive cell transplantation: A first-in-human report.",
    "xml": "<Element 'PubmedArticle' at 0x788502cbd530>"
}