{
    "abstract": "The ambiguity of etiology makes temporomandibular joint osteoarthritis (TMJOA) \"difficult-to-treat\". Emerging evidence underscores the therapeutic promise of exosomes in osteoarthritis management. Nonetheless, challenges such as low yields and insignificant efficacy of current exosome therapies necessitate significant advances. Addressing lower strontium (Sr) levels in arthritic synovial microenvironment, we studied the effect of Sr element on exosomes and miRNA selectively loading in synovial mesenchymal stem cells (SMSCs). Here, we developed an optimized system that boosts the yield of SMSC-derived exosomes (SMSC-EXOs) and improves their miRNA profiles with an elevated proportion of beneficial miRNAs, while reducing harmful ones by pretreating SMSCs with Sr. Compared to untreated SMSC-EXOs, Sr-pretreated SMSC-derived exosomes (Sr-SMSC-EXOs) demonstrated superior therapeutic efficacy by mitigating chondrocyte ferroptosis and reducing osteoclast-mediated joint pain in TMJOA. Our results illustrate Alix's crucial role in Sr-triggered miRNA loading, identifying miR-143-3p as a key anti-TMJOA exosomal component. Interestingly, this system is specifically oriented towards synovium-derived stem cells. The insight into trace element-driven, site-specific miRNA selectively loading in SMSC-EXOs proposes a promising therapeutic enhancement strategy for TMJOA.",
    "authors": [
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.\nFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.",
            "firstname": "Wenxiu",
            "initials": "W",
            "lastname": "Yuan"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Jiaqi",
            "initials": "J",
            "lastname": "Liu"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Zhenzhen",
            "initials": "Z",
            "lastname": "Zhang"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Chengxinyue",
            "initials": "C",
            "lastname": "Ye"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Xueman",
            "initials": "X",
            "lastname": "Zhou"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.",
            "firstname": "Yating",
            "initials": "Y",
            "lastname": "Yi"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Yange",
            "initials": "Y",
            "lastname": "Wu"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Yijun",
            "initials": "Y",
            "lastname": "Li"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.\nLaboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Qinlanhui",
            "initials": "Q",
            "lastname": "Zhang"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.",
            "firstname": "Xin",
            "initials": "X",
            "lastname": "Xiong"
        },
        {
            "affiliation": "Laboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Hengyi",
            "initials": "H",
            "lastname": "Xiao"
        },
        {
            "affiliation": "Laboratory of Aging Research and Department of Geriatrics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. liujin@scu.edu.cn.",
            "firstname": "Jin",
            "initials": "J",
            "lastname": "Liu"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. wangjunv@scu.edu.cn.",
            "firstname": "Jun",
            "initials": "J",
            "lastname": "Wang"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1038/s41368-024-00329-5",
    "journal": "International journal of oral science",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-02-01",
    "pubmed_id": "39890774\n37439514\n37367299\n37691947\n33243424\n34078596\n30771585\n37626033\n28042326\n28279188\n31085006\n33714889\n31285423\n33129987\n33878476\n35927232\n32814390\n36671508\n36379393\n32499639\n31142839\n33435236\n25092378\n33741002\n33024902\n33812609\n35059981\n31845207\n28986288\n5090325\n23117245\n34016181\n24667161\n14749454\n36406252\n33812608\n36048734\n36854760\n35658004\n30021161\n30944935\n18005675\n23542590\n22969426\n32016449\n35978511\n34561933\n30530994\n32049272\n24637612\n35333565\n35148775\n35835783\n30397205\n34183054\n7022654\n34245984\n21090447\n34727384\n30529871\n29092816\n31446120\n31221815\n26233505\n27117408\n34766549\n16908530\n32640214\n31546246\n25732677\n30066874\n37189806\n29581736\n35087090\n30791926",
    "results": null,
    "title": "Strontium-Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment.",
    "xml": "<Element 'PubmedArticle' at 0x7885023539c0>"
}