{
    "abstract": "Studies on physical activity (PA) and dementia mainly focus on activity quantity or intensity. Yet PA requires neuro-coordination of movement, and it is unclear whether complexity of daily activity varies by cognitive status. Thus, we examined the association between PA complexity, using multiscale entropy, and cognitive function, mild cognitive impairment (MCI), and dementia in older adults in the Baltimore Longitudinal Study of Aging (BLSA).\nA total of 637 older adults (age 73.9 \u00b1 11.3 years) in the BLSA completed a 7-day wrist-worn accelerometer assessment and neuropsychological tests from 2015 to 2020. Using logistic regression and structural equation modeling, we examined cross-sectional associations of PA complexity with MCI/dementia and cognition. Cross-lagged panel models (CLPMs) were used to assess bidirectional associations at baseline and 2-year follow-up. Multivariable models were adjusted for age, sex, race, education years, body mass index, and comorbidities.\nParticipants in the lowest tertile of PA complexity had over double the odds of MCI/dementia (odds ratio = 2.63, 95% confidence interval [CI]: 1.02 to 6.79, \nLower complexity of accelerometry-detected movement is associated with poorer cognition and higher risk of MCI/dementia. Future studies should explore whether low PA complexity is an early indicator of dementia.\nPrior studies mainly focused on quantity or intensity of physical activity.Poorer cognitive function was associated with lower complexity of daily activity.Lower complexity of physical activity may be an early indicator of dementia.",
    "authors": [
        {
            "affiliation": "Department of Health and Community Systems University of Pittsburgh School of Nursing Pittsburgh Pennsylvania USA.",
            "firstname": "Yurun",
            "initials": "Y",
            "lastname": "Cai"
        },
        {
            "affiliation": "Hinda and Arthur Marcus Institute for Aging Research Harvard Medical School Boston Massachusetts USA.",
            "firstname": "Junhong",
            "initials": "J",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Department of Health and Community Systems University of Pittsburgh School of Nursing Pittsburgh Pennsylvania USA.",
            "firstname": "Paul W",
            "initials": "PW",
            "lastname": "Scott"
        },
        {
            "affiliation": "Intramural Research Program National Institute on Aging Baltimore Maryland USA.",
            "firstname": "Qu",
            "initials": "Q",
            "lastname": "Tian"
        },
        {
            "affiliation": "Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.\nCenter on Aging and Health Johns Hopkins University Baltimore Maryland USA.",
            "firstname": "Amal A",
            "initials": "AA",
            "lastname": "Wanigatunga"
        },
        {
            "affiliation": "Hinda and Arthur Marcus Institute for Aging Research Harvard Medical School Boston Massachusetts USA.",
            "firstname": "Lewis",
            "initials": "L",
            "lastname": "Lipsitz"
        },
        {
            "affiliation": "Intramural Research Program National Institute on Aging Baltimore Maryland USA.",
            "firstname": "Eleanor M",
            "initials": "EM",
            "lastname": "Simonsick"
        },
        {
            "affiliation": "Intramural Research Program National Institute on Aging Baltimore Maryland USA.",
            "firstname": "Susan M",
            "initials": "SM",
            "lastname": "Resnick"
        },
        {
            "affiliation": "Intramural Research Program National Institute on Aging Baltimore Maryland USA.",
            "firstname": "Luigi",
            "initials": "L",
            "lastname": "Ferrucci"
        },
        {
            "affiliation": "Department of Health and Community Systems University of Pittsburgh School of Nursing Pittsburgh Pennsylvania USA.\nUniversity of Pittsburgh Alzheimer's Disease Research Center Pittsburgh Pennsylvania USA.",
            "firstname": "Dianxu",
            "initials": "D",
            "lastname": "Ren"
        },
        {
            "affiliation": "Department of Health and Community Systems University of Pittsburgh School of Nursing Pittsburgh Pennsylvania USA.\nUniversity of Pittsburgh Alzheimer's Disease Research Center Pittsburgh Pennsylvania USA.",
            "firstname": "Jennifer H",
            "initials": "JH",
            "lastname": "Lingler"
        },
        {
            "affiliation": "Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.\nCenter on Aging and Health Johns Hopkins University Baltimore Maryland USA.",
            "firstname": "Jennifer A",
            "initials": "JA",
            "lastname": "Schrack"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
    "doi": "10.1002/trc2.70077\n10.1016/j.jalz.2011.04.003\n10.1186/s13195-017-0283-5\n10.1212/01.wnl.0000296276.50595.86\n10.1212/WNL.0000000000007021\n10.1212/WNL.0b013e3182535d35\n10.1136/bmj.j2709\n10.1093/gerona/gly029\n10.1093/gerona/glw130\n10.1001/jamainternmed.2019.4707\n10.3233/JAD-215544\n10.1038/s41598-017-03422-4\n10.1016/j.jshs.2016.01.018\n10.1002/alz.12288\n10.1093/GERONA/GLZ231\n10.1111/joim.13024\n10.1093/gerona/glt199\n10.1249/MSS.0000000000000924\n10.1093/gerona/gly243\n10.1103/PhysRevLett.89.068102\n10.1001/jama.1992.03480130122036\n10.1001/archneur.56.3.303\n10.1093/geronj/49.2.M85\n10.1056/NEJM199503023320902\n10.0.12.128/JOER.99.6.323-338\n10.1001/jama.1992.03480130122036\n10.1111/j.1365-2796.2010.02281.x\n10.1249/MSS.0000000000001936\n10.1001/jamanetworkopen.2022.4590\n10.1001/jamanetworkopen.2019.2745\n10.1111/ggi.13284\n10.1093/gerona/glaa294\n10.3233/JAD-160582\n10.1212/WNL.0000000000001658\n10.1016/j.ypmed.2014.12.041\n10.1016/j.jshs.2014.11.001\n10.1007/s10654-013-9773-3\n10.1016/j.yfrne.2017.06.001\n10.1002/hipo.22397\n10.3233/JAD-170221\n10.1016/S0140-6736(24)01296-0\n10.1016/S1474-4422(16)00067-3\n10.1016/j.ncl.2023.01.001",
    "journal": "Alzheimer's & dementia (New York, N. Y.)",
    "keywords": [
        "cognitive function",
        "cognitive impairment",
        "dementia",
        "physical activity",
        "structural equation modeling"
    ],
    "methods": null,
    "publication_date": "2025-04-14",
    "pubmed_id": "40225241\n21575869\n28793924\n18094335\n30787164\n22517108\n28642251\n29509832\n27422439\n31682693\n35599480\n28592844\n30356502\n33860609\n31585008\n32107805\n24336819\n27031744\n30357322\n12190613\n10843903\n11867648\n1482430\n10190820\n8126356\n7838189\n1482430\n20831630\n31095081\n35348711\n31002329\n29488304\n33230557\n27716669\n25957331\n25579505\n23385659\n28614695\n25483019\n29036816\n39096926\n26987699\n37030962",
    "results": "Participants in the lowest tertile of PA complexity had over double the odds of MCI/dementia (odds ratio = 2.63, 95% confidence interval [CI]: 1.02 to 6.79, ",
    "title": "Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging.",
    "xml": "<Element 'PubmedArticle' at 0x78850456e6b0>"
}