{
    "abstract": "To analyze the clinical, radiographic, and microbiological changes around implants with a multiphosphonate-treated surface, prosthetically loaded with two different protocols after 5\u2009years of functional loading.\nA randomized clinical trial was designed to initiate prosthetic loading over single dental implants after 8 (control) or 4\u2009weeks (test). Several variables were analyzed, including patients' level variables, intrasulcular biofilm, and marginal bone level at several time points, from 1 to 60\u2009months after loading.\nA total of 23 patients attended the 5-year follow-up visit. No clinical variable changed over time, except mucosal thickness from dental impressions to prosthesis delivery. No significant radiographic differences were observed either over time or between groups. Microbiologically, there was a change in the microbiome from the constitution of the biological width to the final follow-up. Seven species changed significantly, with a significant increase in Porphyromonas gingivalis and Tannerella forsythia from 12 to 60\u2009months and a decrease in the other species. However, changes in the relative abundance of species over time, whether increasing or decreasing, did not show a correlation with marginal bone loss.\nImplants with a multiphosphonate-treated surface showed no differences in clinical and radiographic variables after 5\u2009years of function, regardless of the prosthetic loading protocol used. From a microbiological point of view, although there was an evolution of the microbiome in the peri-implant sulcus towards Socransky's red circle pathogenic bacteria, no microorganism showed a significant correlation with the radiographic changes produced in the peri-implant bone over time.\nClinicalTrials.gov identifier: NCT03059108.",
    "authors": [
        {
            "affiliation": "Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.\nInstituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.",
            "firstname": "Pablo",
            "initials": "P",
            "lastname": "Galindo-Moreno"
        },
        {
            "affiliation": "Formerly, PhD Program in Clinical Medicine and Public Health, University of Granada, Granada, Spain.\nPrivate Practice, Granada, Spain.",
            "firstname": "Lourdes",
            "initials": "L",
            "lastname": "Gutierrez-Garrido"
        },
        {
            "affiliation": "Instituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.\nDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.\nCentro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III, Madrid, Spain.",
            "firstname": "Juan",
            "initials": "J",
            "lastname": "Duarte"
        },
        {
            "affiliation": "Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.",
            "firstname": "I\u00f1aki",
            "initials": "I",
            "lastname": "Robles-Vera"
        },
        {
            "affiliation": "Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.\nInstituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.\nPhD Program in Biomedicine, University of Granada, Granada, Spain.\nDepartment of Pathology, School of Medicine, University of Granada, Granada, Spain.",
            "firstname": "Natividad",
            "initials": "N",
            "lastname": "Martin-Morales"
        },
        {
            "affiliation": "Instituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.\nDepartment of Pathology, School of Medicine, University of Granada, Granada, Spain.\nInstitute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, Granada, Spain.",
            "firstname": "Francisco",
            "initials": "F",
            "lastname": "O'Valle"
        },
        {
            "affiliation": "Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.\nInstituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.\nFormerly, PhD Program in Clinical Medicine and Public Health, University of Granada, Granada, Spain.",
            "firstname": "Allinson",
            "initials": "A",
            "lastname": "Olaechea"
        },
        {
            "affiliation": "Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.\nInstituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.",
            "firstname": "Ana Bel\u00e9n",
            "initials": "AB",
            "lastname": "Carrillo-Galvez"
        },
        {
            "affiliation": "Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.\nInstituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA, Granada, Spain.",
            "firstname": "Miguel",
            "initials": "M",
            "lastname": "Padial-Molina"
        }
    ],
    "conclusions": "Implants with a multiphosphonate-treated surface showed no differences in clinical and radiographic variables after 5\u2009years of function, regardless of the prosthetic loading protocol used. From a microbiological point of view, although there was an evolution of the microbiome in the peri-implant sulcus towards Socransky's red circle pathogenic bacteria, no microorganism showed a significant correlation with the radiographic changes produced in the peri-implant bone over time.",
    "copyrights": "\u00a9 2025 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
    "doi": "10.1111/clr.14426",
    "journal": "Clinical oral implants research",
    "keywords": [
        "early loading",
        "implant surface",
        "marginal bone loss",
        "microbiome",
        "peri\u2010implantitis"
    ],
    "methods": null,
    "publication_date": "2025-03-10",
    "pubmed_id": "40062725",
    "results": "A total of 23 patients attended the 5-year follow-up visit. No clinical variable changed over time, except mucosal thickness from dental impressions to prosthesis delivery. No significant radiographic differences were observed either over time or between groups. Microbiologically, there was a change in the microbiome from the constitution of the biological width to the final follow-up. Seven species changed significantly, with a significant increase in Porphyromonas gingivalis and Tannerella forsythia from 12 to 60\u2009months and a decrease in the other species. However, changes in the relative abundance of species over time, whether increasing or decreasing, did not show a correlation with marginal bone loss.",
    "title": "Evolution in the Peri-Implant Oral Microbiome and Their Relationship to Long-Term Marginal Bone Loss: A Randomized Clinical Study.",
    "xml": "<Element 'PubmedArticle' at 0x788505d1a0c0>"
}