{
    "abstract": "Long-term pulmonary sequelae of Coronavirus 2019 (COVID-19) remain unclear. Thus, we aimed to establish post-COVID-19 temporal changes in chest computed tomography (CT) features of pulmonary fibrosis and to investigate associations with respiratory symptoms and physiological parameters at 3 and 12 months' follow-up. Adult patients who attended our initial COVID-19 follow-up service and developed chest CT features of interstitial lung disease, in addition to cases identified using British Society of Thoracic Imaging codes, were evaluated retrospectively. Clinical data were gathered on respiratory symptoms and physiological parameters at baseline, 3 months, and 12 months. Corresponding chest CT scans were reviewed by two thoracic radiologists. Associations between CT features and functional correlates were estimated using random effects logistic or linear regression adjusted for age, sex and body mass index. In total, 58 patients were assessed. No changes in reticular pattern, honeycombing, traction bronchiectasis/bronchiolectasis index or pulmonary distortion were observed. Subpleural curvilinear lines were associated with lower odds of breathlessness over time. Parenchymal bands were not associated with breathlessness or impaired lung function overall. Based on our results, we conclude that post-COVID-19 chest CT features of irreversible pulmonary fibrosis remain static over time; other features either resolve or remain unchanged. Subpleural curvilinear lines do not correlate with breathlessness. Parenchymal bands are not functionally significant. An awareness of the different potential functional implications of post-COVID-19 chest CT changes is important in the assessment of patients who present with multi-systemic sequelae of COVID-19 infection.",
    "authors": [
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and NIHR Imperial BRC clinical research fellow in respiratory medicine, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Kartik",
            "initials": "K",
            "lastname": "Kumar"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and clinical research fellow in respiratory medicine and lung cancer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Ratnaprashanthika",
            "initials": "R",
            "lastname": "Ratnakumar"
        },
        {
            "affiliation": "Bristol Medical School, University of Bristol, Bristol, UK.",
            "firstname": "Simon M",
            "initials": "SM",
            "lastname": "Collin"
        },
        {
            "affiliation": "NIHR Health Protection Research Unit in Respiratory Infections, Imperial College London, London, UK.",
            "firstname": "Luis C",
            "initials": "LC",
            "lastname": "Berrocal-Almanza"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.",
            "firstname": "Piera",
            "initials": "P",
            "lastname": "Ricci"
        },
        {
            "affiliation": "Imperial College School of Medicine, Imperial College London, London, UK.",
            "firstname": "Mustafa",
            "initials": "M",
            "lastname": "Al-Zubaidy"
        },
        {
            "affiliation": "National Heart and Lung Institute, Imperial College London, London, UK, and honorary clinical senior lecturer, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.",
            "firstname": "Robina K",
            "initials": "RK",
            "lastname": "Coker"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and honorary clinical senior lecturer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Meg",
            "initials": "M",
            "lastname": "Coleman"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and honorary clinical senior lecturer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Sarah L",
            "initials": "SL",
            "lastname": "Elkin"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and clinical senior lecturer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Patrick",
            "initials": "P",
            "lastname": "Mallia"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and clinical senior lecturer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Jamilah",
            "initials": "J",
            "lastname": "Meghji"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and honorary clinical senior lecturer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Clare",
            "initials": "C",
            "lastname": "Ross"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.",
            "firstname": "Georgina K",
            "initials": "GK",
            "lastname": "Russell"
        },
        {
            "affiliation": "National Heart and Lung Institute, Imperial College London, London, UK, and honorary clinical senior lecturer, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.",
            "firstname": "Katie",
            "initials": "K",
            "lastname": "Ward"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and honorary clinical senior lecturer, National Heart and Lung Institute, Imperial College London, London, UK.",
            "firstname": "Melissa",
            "initials": "M",
            "lastname": "Wickremasinghe"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.",
            "firstname": "Sarah",
            "initials": "S",
            "lastname": "Sheard"
        },
        {
            "affiliation": "National Heart and Lung Institute, Imperial College London, London, UK, and professor of practice (radiology), Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.\nJoint senior authors.",
            "firstname": "Susan J",
            "initials": "SJ",
            "lastname": "Copley"
        },
        {
            "affiliation": "St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK and professor of respiratory medicine, National Heart and Lung Institute, Imperial College London, London, UK onn.kon@nhs.net.\nJoint senior authors.",
            "firstname": "Onn Min",
            "initials": "OM",
            "lastname": "Kon"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 Royal College of Physicians 2023. All rights reserved.",
    "doi": "10.7861/clinmed.2023-0059",
    "journal": "Clinical medicine (London, England)",
    "keywords": [
        "COVID-19",
        "CT",
        "lung function tests",
        "pulmonary fibrosis",
        "respiratory symptoms"
    ],
    "methods": null,
    "publication_date": "2023-09-30",
    "pubmed_id": "37775167\n33172844\n33827856\n33596594\n32933519\n34532368\n35694728\n35174188\n34609153\n33732719\n34313468\n34313470\n34609195\n33964245\n36561827\n9105081\n12663338\n12805557\n35338102\n33497317\n35887810\n35536134\n34703831\n33303539\n36457159\n35348379\n34520845\n36216402\n33927016",
    "results": null,
    "title": "Chest CT features and functional correlates of COVID-19 at 3 months and 12 months follow-up.",
    "xml": "<Element 'PubmedArticle' at 0x7885051dfc40>"
}