{
    "abstract": "Pulmonary hypertension is a severe disease with high mortality rates due to right ventricular (RV) failure. The molecular and cellular processes involved in RV remodeling, including Ca\nWe used the chronic thromboembolic pulmonary hypertension (CTEPH) pig model, which leads to progressive RV hypertrophy and dysfunction. Cellular, molecular unbiased global transcriptional profiling and biochemical analyses were performed on RV cardiomyocytes from CTEPH and Sham-operated pigs.\nCTEPH pigs replicated the hemodynamics and histological changes of human CTEPH features. Transcriptome analysis in Sham and CTEPH pigs revealed molecular RV remodeling close to human patients with pulmonary arterial hypertension with decompensated RV function and notably identified changes in genes involved in Ca\nOur data reveal cellular Ca",
    "authors": [
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).",
            "firstname": "Fabrice",
            "initials": "F",
            "lastname": "Antigny"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Rui",
            "initials": "R",
            "lastname": "Luo"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Romain",
            "initials": "R",
            "lastname": "Perrier"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).",
            "firstname": "Bastien",
            "initials": "B",
            "lastname": "Masson"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Chirurgie Thoracique, Vasculaire et Transplantation Cardio-Pulmonaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (G.F., O.M.).",
            "firstname": "Guillaume",
            "initials": "G",
            "lastname": "Fadel"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).",
            "firstname": "Gr\u00e9goire",
            "initials": "G",
            "lastname": "Ruffenach"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).",
            "firstname": "Ana\u00efs",
            "initials": "A",
            "lastname": "Saint-Martin Willer"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Chirurgie Cardiaque et Vasculaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (A.A., S.D.V., D.B., J. Guihaire).",
            "firstname": "Ali",
            "initials": "A",
            "lastname": "Akamkam"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).",
            "firstname": "Julien",
            "initials": "J",
            "lastname": "Grynblat"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Pneumologie et Soins Intensifs Respiratoires, Centre de R\u00e9f\u00e9rence de l'Hypertension Pulmonaire, Le Kremlin-Bic\u00eatre, France (X.J., D.M., M.H.).",
            "firstname": "Xavier",
            "initials": "X",
            "lastname": "Ja\u00efs"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Pneumologie et Transplantation Pulmonaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (J.L.P.).",
            "firstname": "Jer\u00f4me",
            "initials": "J",
            "lastname": "Le Pavec"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Chirurgie Cardiaque et Vasculaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (A.A., S.D.V., D.B., J. Guihaire).",
            "firstname": "Simon",
            "initials": "S",
            "lastname": "Dang Van"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Chirurgie Cardiaque et Vasculaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (A.A., S.D.V., D.B., J. Guihaire).",
            "firstname": "Doroth\u00e9e",
            "initials": "D",
            "lastname": "Brunet"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Florence",
            "initials": "F",
            "lastname": "Lefebvre"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Garance",
            "initials": "G",
            "lastname": "G\u00e9rard"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, Inserm, CNRS, Ing\u00e9nierie et Plateformes au Service de l'Innovation Th\u00e9rapeutique-Plateforme MIPSIT, Orsay, France (S.D.).",
            "firstname": "S\u00e9verine",
            "initials": "S",
            "lastname": "Domenichini"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).",
            "firstname": "Ang\u00e8le",
            "initials": "A",
            "lastname": "Bo\u00ebt"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Chirurgie Cardiaque et Vasculaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (A.A., S.D.V., D.B., J. Guihaire).",
            "firstname": "Julien",
            "initials": "J",
            "lastname": "Guihaire"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Ana-Maria",
            "initials": "AM",
            "lastname": "Gomez"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Pneumologie et Soins Intensifs Respiratoires, Centre de R\u00e9f\u00e9rence de l'Hypertension Pulmonaire, Le Kremlin-Bic\u00eatre, France (X.J., D.M., M.H.).",
            "firstname": "David",
            "initials": "D",
            "lastname": "Montani"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Jean-Pierre",
            "initials": "JP",
            "lastname": "Benitah"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Pneumologie et Soins Intensifs Respiratoires, Centre de R\u00e9f\u00e9rence de l'Hypertension Pulmonaire, Le Kremlin-Bic\u00eatre, France (X.J., D.M., M.H.).",
            "firstname": "Marc",
            "initials": "M",
            "lastname": "Humbert"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, INSERM, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Th\u00e9rapeutique (HPPIT), AP-HP, H\u00f4pital Bic\u00eatre, H\u00f4pital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France (F.A., B.M., G.F., G.R., A.S.-M.W., A.A., J. Grynblat, X.J., J.L.P., S.D.V., D.B., A.B., J. Guihaire, D.M., M.H., O.M.).\nService de Chirurgie Thoracique, Vasculaire et Transplantation Cardio-Pulmonaire, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France (G.F., O.M.).",
            "firstname": "Olaf",
            "initials": "O",
            "lastname": "Mercier"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Orsay, France (R.L., R.P., F.L., G.G., A.-M.G., J.-P.B., J.S.).",
            "firstname": "Jessica",
            "initials": "J",
            "lastname": "Sabourin"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/CIRCHEARTFAILURE.124.012293",
    "journal": "Circulation. Heart failure",
    "keywords": [
        "animals",
        "heart failure",
        "humans",
        "sarcoplasmic reticulum",
        "swine"
    ],
    "methods": null,
    "publication_date": "2025-04-18",
    "pubmed_id": "40248873",
    "results": "CTEPH pigs replicated the hemodynamics and histological changes of human CTEPH features. Transcriptome analysis in Sham and CTEPH pigs revealed molecular RV remodeling close to human patients with pulmonary arterial hypertension with decompensated RV function and notably identified changes in genes involved in Ca",
    "title": "Ca",
    "xml": "<Element 'PubmedArticle' at 0x7885031edda0>"
}