{
    "abstract": "A total of 204 infertile women attending the Infertility Clinic of the Medical Center Hospital of Vermont were studied for the possible role of Chlamydia trachomatis and intrauterine contraceptive device (IUCD) use as factors related to their infertility. All patients had had at least 1 year of involuntary infertility. All but one woman had negative cultures for C. trachomatis, but a highly significant correlation (p less than 0.001) was evident between evidence of prior pelvic inflammatory disease (PPID) as documented by hysterosalpingograms and/or laparoscopy and the prevalence of chlamydial antibody. Furthermore, a significant (p = 0.01) correlation could be shown between the prevalence of the antibodies and adnexal adhesions. IUCD use could also be shown between the prevalence of the antibodies and adnexal adhesions. IUCD use could also be shown to correlate significantly (p less than 0.001) with PPID, and a detailed statistical analysis indicated that the two factors, antibody to C. trachomatis and a history of IUCD use, were independently related to PPID. Only about one third of the patients with PPID could ever recall having had an illness consistent with PID. Subsequent to the infertility workup, 76 of these women became pregnant and there was a significant (p less than 0.001) correlation between the occurrence of ectopic pregnancy and antibody to C. trachomatis. A significant (p = 0.01) correlation was also noted between a history of IUCD use and subsequent ectopic pregnancy. From these data it appears that antecedent infection with C. trachomatis, as measured by antibody prevalence, and a history of IUCD use are important factors in infertility of tubal origin and are also related to ectopic pregnancy.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "D W",
            "initials": "DW",
            "lastname": "Gump"
        },
        {
            "affiliation": null,
            "firstname": "M",
            "initials": "M",
            "lastname": "Gibson"
        },
        {
            "affiliation": null,
            "firstname": "T",
            "initials": "T",
            "lastname": "Ashikaga"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1016/0002-9378(83)91044-x",
    "journal": "American journal of obstetrics and gynecology",
    "keywords": [
        "Adnexitis",
        "Age Factors",
        "Antibodies--analysis",
        "Biology",
        "Contraception",
        "Contraceptive Methods--complications",
        "Demographic Factors",
        "Diseases",
        "Examinations And Diagnoses",
        "Family Planning",
        "Fertility",
        "Fertility Measurements",
        "Histology",
        "Hysterosalpingography",
        "Immunity",
        "Immunologic Factors",
        "Incidence",
        "Infections",
        "Infertility--women",
        "Iud--complications",
        "Laboratory Examinations And Diagnoses",
        "Laboratory Procedures",
        "Laparoscopy",
        "Measurement",
        "Pelvic Infections",
        "Pelvic Inflammatory Disease",
        "Physiology",
        "Population",
        "Population Dynamics",
        "Pregnancy",
        "Pregnancy Outcomes",
        "Pregnancy Rate",
        "Pregnancy, Ectopic",
        "Reproduction",
        "Reproductive Tract Infections",
        "Research Methodology"
    ],
    "methods": null,
    "publication_date": "1983-05-15",
    "pubmed_id": "6846431",
    "results": null,
    "title": "Evidence of prior pelvic inflammatory disease and its relationship to Chlamydia trachomatis antibody and intrauterine contraceptive device use in infertile women.",
    "xml": "<Element 'PubmedArticle' at 0x788505522fc0>"
}