{
    "abstract": "The best thromboprophylaxis for pregnant women with congenital antithrombin deficiency (CAD) is controversial.\nTo clarify the effectiveness of a protocol for venous thromboembolism (VTE) prevention in pregnant women with CAD.\nWomen at high risk of VTE were administered antithrombin concentrate and heparin after conception, whereas those at low risk of VTE were administered heparin alone until delivery. All women received antithrombin concentrate at delivery except for one who was diagnosed with CAD.\nTen women had CAD, including one in the high-risk group and nine in the low-risk group. No women had VTE at delivery as per the protocol for VTE prevention. Almost all women had increased antithrombin activity before delivery followed by maintenance at\u2009\u2265\u200970% due to antithrombin concentrate administration. VTE prophylaxis during and after delivery was successful in all women with CAD. However, one woman in the low-risk group did not receive heparin and developed VTE induced by severe hyperemesis at 9 gestational weeks, before the diagnosis of CAD. Women in the high-risk group received antithrombin concentrate after delivery but had increased D-dimer levels at postpartum.\nOur protocol to prevent VTE in pregnant women with CAD is safe and effective.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. mmamoru@hirakata.kmu.ac.jp.\nDepartment of Obstetrics and Gynecology, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan. mmamoru@hirakata.kmu.ac.jp.",
            "firstname": "Mamoru",
            "initials": "M",
            "lastname": "Morikawa"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Iwate Prefectural Chubu Hospital, Kitakami, Japan.",
            "firstname": "Masahiro",
            "initials": "M",
            "lastname": "Ieko"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Kinuko",
            "initials": "K",
            "lastname": "Nakagawa-Akabane"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Takeshi",
            "initials": "T",
            "lastname": "Umazume"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Kentaro",
            "initials": "K",
            "lastname": "Chiba"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Satoshi",
            "initials": "S",
            "lastname": "Kawaguchi"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Michinori",
            "initials": "M",
            "lastname": "Mayama"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Yoshihiro",
            "initials": "Y",
            "lastname": "Saito"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
            "firstname": "Hidemichi",
            "initials": "H",
            "lastname": "Watari"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2022. Japanese Society of Hematology.",
    "doi": "10.1007/s12185-022-03327-7\n10.1160/TH08-10-0672\n10.1016/j.thromres.2010.08.010\n10.1016/j.ajog.2005.11.008\n10.1111/j.1365-2141.2005.05847.x\n10.1182/bloodadvances.2018024802\n10.1016/j.chest.2015.11.026\n10.1160/TH12-09-0663\n10.1016/j.thromres.2011.05.011\n10.1213/01.ane.0000275194.86608.ac\n10.2174/1389450054546042\n10.1016/s0002-9378(96)70396-4\n10.1016/S0168-8278(99)80190-1\n10.1515/jpm.2011.026\n10.1515/jpm.2010.049\n10.1016/j.ejogrb.2009.12.004\n10.1007/s00277-013-1892-0\n10.1097/AOG.0000000000002703\n10.1182/blood-2016-03-703728\n10.1016/s1521-6926(03)00022-7\n10.1111/jog.14879\n10.1177/1060028016651276\n10.1136/bmj.j4452\n10.1080/17474086.2019.1611424\n10.1016/j.preghy.2013.03.003\n10.1503/cmaj.060870\n10.1111/j.1538-7836.2004.01108.x",
    "journal": "International journal of hematology",
    "keywords": [
        "Antithrombin concentrate",
        "Caesarean section",
        "Congenital antithrombin deficiency",
        "D-dimer",
        "Heparin",
        "Pregnancy",
        "Thromboprophylaxis",
        "Venous thromboembolism"
    ],
    "methods": null,
    "publication_date": "2022-03-23",
    "pubmed_id": "35316497\n20833412\n16647915\n16398652\n30482767\n26867832\n23196409\n21645918\n17717229\n16026276\n8572009\n21627490\n20443661\n20047788\n23016265\n23999648\n27613196\n12763490\n34169611\n27281301\n29074563\n31116611\n26106030\n17296957\n15670031",
    "results": "Ten women had CAD, including one in the high-risk group and nine in the low-risk group. No women had VTE at delivery as per the protocol for VTE prevention. Almost all women had increased antithrombin activity before delivery followed by maintenance at\u2009\u2265\u200970% due to antithrombin concentrate administration. VTE prophylaxis during and after delivery was successful in all women with CAD. However, one woman in the low-risk group did not receive heparin and developed VTE induced by severe hyperemesis at 9 gestational weeks, before the diagnosis of CAD. Women in the high-risk group received antithrombin concentrate after delivery but had increased D-dimer levels at postpartum.",
    "title": "Prevention of venous thromboembolism in pregnant women with congenital antithrombin deficiency: a retrospective study of a candidate protocol.",
    "xml": "<Element 'PubmedArticle' at 0x788503d3b5b0>"
}