{
    "abstract": "ONO-802 was used in the form of vaginal suppositories for the termination of early pregnancy in 63 healthy volunteers. Fifty-four (86%) of the 63 cases had complete abortions and remaining 9 (14%) had incomplete abortions. One (1.6%) of the 63 cases complained of nausea and vomiting, and 3 (4.8%) complained of headaches. No other side effects were observed. These results suggest that ONO-802 is acceptable in the form of vaginal suppositories for the termination of early pregnancy.\n63 pregnant women (aged 20-35 years) with a parity range from 0-3 (average 1.6+-.8) were treated in vaginal suppository form with ONO-802 at either .5 or 1 mg. Pregnancy-stage range was from 11-66 days beyond last expected menstrual period. Patients were instructed to insert 1 suppository every 3 hours for a maximum of 5 applications. Estradiol and progesterone levels were assayed from venous blood samples before (control) administration and 3, 6, and 24 hours postadministration. No changes were present at onset of contractions, but all fractions decreased by 48 hours postadministration. 63/63 responded with hemorrhage. 54/63 (86%) had complete abortions (89% with 1 mg, 84% with .5 mg). 9/63 were incomplete (14%), but there was sufficient dilatation for subsequent uterine content removal. With the 1-mg dose, uterine contractions and hemorrhage occurred about 1.5 hours sooner. 1/63 (1.6%) complained of nausea and vomiting, and 3 (4.8%) complained of headache. No other side effects were observed.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "S",
            "initials": "S",
            "lastname": "Takagi"
        },
        {
            "affiliation": null,
            "firstname": "H",
            "initials": "H",
            "lastname": "Sakata"
        },
        {
            "affiliation": null,
            "firstname": "T",
            "initials": "T",
            "lastname": "Yoshida"
        },
        {
            "affiliation": null,
            "firstname": "K",
            "initials": "K",
            "lastname": "Den"
        },
        {
            "affiliation": null,
            "firstname": "T K",
            "initials": "TK",
            "lastname": "Fujii"
        },
        {
            "affiliation": null,
            "firstname": "H",
            "initials": "H",
            "lastname": "Amemiya"
        },
        {
            "affiliation": null,
            "firstname": "M",
            "initials": "M",
            "lastname": "Tomita"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1016/0090-6980(78)90159-4",
    "journal": "Prostaglandins",
    "keywords": [
        "Abortifacient Agents",
        "Abortion, Induced--complications",
        "Biology",
        "Clinical Research",
        "Contraception",
        "Contraceptive Methods",
        "Diarrhea",
        "Endocrine System",
        "Estradiol--analysis",
        "Estrogens",
        "Family Planning",
        "Fertility Control, Postconception",
        "Hormones",
        "Nausea",
        "Pain",
        "Physiology",
        "Pregnancy",
        "Pregnancy, First Trimester",
        "Progestational Hormones",
        "Progesterone--analysis",
        "Prostaglandins--administraction and dosage",
        "Prostaglandins--side effects",
        "Reproduction",
        "Research Methodology",
        "Vaginal Spermicides",
        "Vaginal Suppository",
        "Vomiting"
    ],
    "methods": null,
    "publication_date": "1978-05-01",
    "pubmed_id": "704915",
    "results": null,
    "title": "Termination of early pregnancy by ONO-802 suppositories (16,16-dimethyl-trans-delta2-PGE1 methyl ester).",
    "xml": "<Element 'PubmedArticle' at 0x7885038b66b0>"
}