{
    "abstract": "Prior meta-analyses indicate polycystic ovary syndrome (PCOS) is associated with cardiovascular diseases (CVDs), but have high statistical heterogeneity, likely because PCOS is a heterogenous syndrome diagnosed by having any two of the three components: hyperandrogenism, oligomenorrhea/menstrual irregularity or polycystic ovaries. Several studies report higher risk of CVDs from individual PCOS components, but a comprehensive assessment of how each component contributes to CVD risk is lacking. This study aims to assess CVD risk for women with one of the PCOS components.\nA systematic review and meta-analysis of observational studies was conducted. PubMed, Scopus, and Web of Science were searched without restrictions in July 2022. Studies meeting inclusion criteria examined the association between PCOS components and risk of a CVD. Two reviewers independently assessed abstracts and full-text articles, and extracted data from eligible studies. Where appropriate, relative risk (RR) and 95% confidence interval (CI) were estimated by random-effects meta-analysis. Statistical heterogeneity was assessed using the \nOligo-amenorrhea/menstrual irregularity is associated with greater risk of overall CVD, CHD, and MI. More research is needed to assess the risks associated with hyperandrogenism or polycystic ovaries.",
    "authors": [
        {
            "affiliation": "School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0SP, UK.",
            "firstname": "Andre C Q",
            "initials": "ACQ",
            "lastname": "Lo"
        },
        {
            "affiliation": "Liverpool Hospital, Liverpool, NSW 2170, Australia.\nFaculty of Medicine, University of New South Wales, Kensington, NSW 2052, Australia.\nSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.",
            "firstname": "Charmaine Chu Wen",
            "initials": "CCW",
            "lastname": "Lo"
        },
        {
            "affiliation": "Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.\nCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0BB, UK.",
            "firstname": "Clare",
            "initials": "C",
            "lastname": "Oliver-Williams"
        }
    ],
    "conclusions": "Oligo-amenorrhea/menstrual irregularity is associated with greater risk of overall CVD, CHD, and MI. More research is needed to assess the risks associated with hyperandrogenism or polycystic ovaries.",
    "copyrights": "\u00a9 The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.",
    "doi": "10.1093/ehjopen/oead061",
    "journal": "European heart journal open",
    "keywords": [
        "Polycystic ovary syndrome",
        "cardiovascular disease",
        "hyperandrogenism polycystic ovaries",
        "meta-analysis",
        "oligomenorrhea",
        "systematic review"
    ],
    "methods": null,
    "publication_date": "2023-07-05",
    "pubmed_id": "37404840\n30463276\n32995872\n33282917\n14711538\n30024653\n33781348\n10789670\n22587842\n18436948\n33961175\n12543843\n32673040\n11994334\n32998909\n17160211\n17303313\n25359859\n28959377\n10230834\n31016155\n29492235\n20451189\n34817084\n16409898\n29408955\n11739984\n27143682\n24517154\n12975257\n27742423\n26385535\n31054196\n15269926\n20980429\n19781047\n25239303\n27756332\n19180069\n2895373\n12788834\n15788499\n21547513\n26360602\n22959762\n23048011\n17405972\n30062549\n33334002",
    "results": null,
    "title": "Cardiovascular disease risk in women with hyperandrogenism, oligomenorrhea/menstrual irregularity or polycystic ovaries (components of polycystic ovary syndrome): a systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788502a22750>"
}