{
    "abstract": "Low molecular weight heparin (FR-860), and conventional unfractionated heparin (UF-heparin) were fractionated by rabbit antithrombin III (AT III)-Sepharose, and the effects of each affinity fraction on the coagulation and fibrinolytic activities were investigated. FR-860 was fractionated to no-affinity, low-affinity (LA) and high-affinity (HA) fractions, and UF-heparin to LA and HA fractions. The HA fractions showed higher activities regarding the prolongation of activated partial thromboplastin time, anti-factor Xa activity and antithrombin activity compared with those of LA. The HA and LA fractions exhibited the enhancement of heparin cofactor II (HC II) activity and fibrinolytic activity in a dose-dependent manner. These results suggest that the antithrombotic activity of FR-860 is exerted through AT III and other mechanism such as HC II-mediated system.",
    "authors": [
        {
            "affiliation": "Pharmacological Laboratories, Kissei Pharmaceutical Co. Ltd., Hotaka, Japan.",
            "firstname": "S",
            "initials": "S",
            "lastname": "Hamano"
        },
        {
            "affiliation": null,
            "firstname": "M",
            "initials": "M",
            "lastname": "Nishiyama"
        },
        {
            "affiliation": null,
            "firstname": "S",
            "initials": "S",
            "lastname": "Kikuchi"
        },
        {
            "affiliation": null,
            "firstname": "H",
            "initials": "H",
            "lastname": "Komatsu"
        },
        {
            "affiliation": null,
            "firstname": "H",
            "initials": "H",
            "lastname": "Miyata"
        },
        {
            "affiliation": null,
            "firstname": "S",
            "initials": "S",
            "lastname": "Ikeda"
        },
        {
            "affiliation": null,
            "firstname": "N",
            "initials": "N",
            "lastname": "Sakuragawa"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1016/0049-3848(92)90280-n",
    "journal": "Thrombosis research",
    "keywords": [],
    "methods": null,
    "publication_date": "1992-05-15",
    "pubmed_id": "1329257",
    "results": null,
    "title": "Study of low molecular weight heparin effect on the relation between anticoagulant activity and antithrombin III affinity.",
    "xml": "<Element 'PubmedArticle' at 0x788503672570>"
}