{
    "abstract": "We examined whether riluzole treatment modifies the associations between the dietary glycemic index (GI) and load (GL) and disease progression in amyotrophic lateral sclerosis (ALS).\nSporadic ALS patients in the Multicenter Cohort Study of Oxidative Stress who completed a baseline food frequency questionnaire were included (n\u2009=\u2009304). Interactions between baseline riluzole treatment and GI/GL on functional decline and tracheostomy-free survival were examined using linear regression and Cox proportional hazard models adjusted for covariates. Age, sex, disease duration, diagnostic certainty, body mass index, bulbar onset, revised ALS functional rating scale (ALSFRS-r) total score, and forced vital capacity, from baseline were included as covariates.\nBaseline higher GI and GL were associated with less decline of ALSFRS-r total score at 3-month follow-up in the riluzole treatment group (RTG) but not in the no-riluzole group (NRG). When quartile groups were used, GI second [\u03b2\u2009=\u2009-1.9, 95% CI (-4.1, -0.2), p\u2009=\u20090.07], third [\u03b2\u2009=\u2009-3.0, 95% CI (-5.1, -0.8), p\u2009<\u20090.01] and fourth [\u03b2\u2009=\u2009-2.2, 95% CI (-4.3, -0.01), p\u2009<\u20090.05] quartile groups were associated with less ALSFRS-r decline at 3-months compared to the first quartile group (GI\u2009<\u200947.2) among the RTG. Similarly, GL fourth quartile group (GL\u2009>\u2009109.5) was associated with less ALSFRS-r decline at 3 months compared to the first quartile group [\u03b2\u2009=\u2009-2.6, 95% CI (-4.7, -0.5), p\u2009<\u20090.05] among the RTG. In NRG, no statistically significant differences in ALSFRS-r decline were found among GI/GL quartile groups.\nHigh dietary GI and GL are associated with a slower functional decline only among ALS patients taking riluzole.",
    "authors": [
        {
            "affiliation": "Department of Neurology, Columbia University Irving Medical Center, New York, USA.",
            "firstname": "Ikjae",
            "initials": "I",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Neurology, Columbia University Irving Medical Center, New York, USA.",
            "firstname": "Hiroshi",
            "initials": "H",
            "lastname": "Mitsumoto"
        },
        {
            "affiliation": "Department of Biostatistics and Psychiatry, Columbia University, New York, USA.",
            "firstname": "Seonjoo",
            "initials": "S",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.",
            "firstname": "Edward",
            "initials": "E",
            "lastname": "Kasarskis"
        },
        {
            "affiliation": "Departments of Pediatrics and Medicine, Columbia University Irving Medical Center, New York, USA.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Rosenbaum"
        },
        {
            "affiliation": "Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA.",
            "firstname": "Pam",
            "initials": "P",
            "lastname": "Factor-Litvak"
        },
        {
            "affiliation": "Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA.",
            "firstname": "Jeri W",
            "initials": "JW",
            "lastname": "Nieves"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",
    "doi": "10.1002/acn3.52294",
    "journal": "Annals of clinical and translational neurology",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-01-09",
    "pubmed_id": "39783196\n20236142\n8302340\n8959996\n12021952\n22419278\n37975189\n38775034\n25571962\n38270730\n19280185\n23834207\n34145880\n11464847\n22892641\n15642901\n12081815\n16155266\n29598923\n21607987\n31334681\n8787245\n27249331\n33467943\n39329381",
    "results": "Baseline higher GI and GL were associated with less decline of ALSFRS-r total score at 3-month follow-up in the riluzole treatment group (RTG) but not in the no-riluzole group (NRG). When quartile groups were used, GI second [\u03b2\u2009=\u2009-1.9, 95% CI (-4.1, -0.2), p\u2009=\u20090.07], third [\u03b2\u2009=\u2009-3.0, 95% CI (-5.1, -0.8), p\u2009<\u20090.01] and fourth [\u03b2\u2009=\u2009-2.2, 95% CI (-4.3, -0.01), p\u2009<\u20090.05] quartile groups were associated with less ALSFRS-r decline at 3-months compared to the first quartile group (GI\u2009<\u200947.2) among the RTG. Similarly, GL fourth quartile group (GL\u2009>\u2009109.5) was associated with less ALSFRS-r decline at 3 months compared to the first quartile group [\u03b2\u2009=\u2009-2.6, 95% CI (-4.7, -0.5), p\u2009<\u20090.05] among the RTG. In NRG, no statistically significant differences in ALSFRS-r decline were found among GI/GL quartile groups.",
    "title": "Interaction between riluzole treatment and dietary glycemic index in the disease progression of amyotrophic lateral sclerosis.",
    "xml": "<Element 'PubmedArticle' at 0x7885037e5b20>"
}