{
    "abstract": "This study aims to assess the neonatal outcomes related to maternal SARS-COV-2 infection.\nIn this study, we identified newborns born between May 14 and August 31, 2020, to mothers who were PCR-SRAS-CoV-2 positive at the time of delivery. From the cohort of 974 infants, we performed a nested case-control study.\nDuring the study period, 133 (13.7%) mothers were positive for SARS-CoV-2. Among the 35 pregnant women with COVID-19 symptoms (26.3%), cough was the most common symptom, present in half of the cases. Four of them have progressed to critical pneumonia requiring transfer to intensive care unit. The neonates from mothers with positive SARS-CoV-2-RT-PCR, were routinely tested for COVID-19 within the first 24\u00a0h after labor, and 3 other newborns tested in the presence of symptoms. There was no significant difference between the two groups with respect to preterm birth, meconium-stained amniotic fluid distress, and neonatal asphyxia. Most infants were breastfed at birth, regardless of their mothers' COVID-19 status. In COVID-19-positive pregnant women admitted to intensive care unit, the proportion of preterm births (OR=12.5 [1.7-90.5]), fetal death in utero (OR=25.9 [2.2-305]) and admission in neonatal intensive care unit admission (OR=13.4 [3.0-60]), appeared higher than the controls. No maternal deaths were recorded.\nOur data suggest little neonatal morbidity associated with maternal COVID-19, except for those born to mothers admitted to intensive care unit. However, under breastfeeding conditions with rigorous hygiene precautions and parental education, the risk of transmission of SARS-COV-2 virus to the newborn was very low.",
    "authors": [
        {
            "affiliation": "Pediatric Unit, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; EA 3593, Faculty of Medicine, Universit\u00e9 des Antilles et de la Guyane, Guadeloupe; Department of Gynecology and Obstetrics, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana. Electronic address: elengafr@yahoo.fr.",
            "firstname": "N",
            "initials": "N",
            "lastname": "Elenga"
        },
        {
            "affiliation": "Neonatal Unit, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; Department of Gynecology and Obstetrics, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana.",
            "firstname": "M-J",
            "initials": "MJ",
            "lastname": "Wandji"
        },
        {
            "affiliation": "Pediatric Unit, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; EA 3593, Faculty of Medicine, Universit\u00e9 des Antilles et de la Guyane, Guadeloupe; Neonatal Unit, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; Department of Gynecology and Obstetrics, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; Centre d'Investigation Clinique Antilles-Guyane, Inserm 1424, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; Parasitology-Mycology, EA 3593, Faculty of Medicine, Universit\u00e9 des Antilles et de la Guyane, Guadeloupe.",
            "firstname": "J",
            "initials": "J",
            "lastname": "Siban"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; Centre d'Investigation Clinique Antilles-Guyane, Inserm 1424, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Nacher"
        },
        {
            "affiliation": "EA 3593, Faculty of Medicine, Universit\u00e9 des Antilles et de la Guyane, Guadeloupe; Department of Gynecology and Obstetrics, Centre Hospitalier de Cayenne, Rue des flamboyants, BP 6006, 97306 Cedex Cayenne, French Guiana; Parasitology-Mycology, EA 3593, Faculty of Medicine, Universit\u00e9 des Antilles et de la Guyane, Guadeloupe.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Demar"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2022. Published by Elsevier Ltd.",
    "doi": "10.1016/j.jiph.2022.06.003\n10.1503/cmaj.200821\n10.3389/fimmu.2020.575197\n10.1016/j.ajog.2021.07.009\n10.1111/1471-0528.16369\n10.1136/bmjgh-2021-007780",
    "journal": "Journal of infection and public health",
    "keywords": [
        "Breastfeeding",
        "Low risk",
        "Mild infection",
        "Newborn",
        "SARS-COV-2 positive mother"
    ],
    "methods": null,
    "publication_date": "2022-06-18",
    "pubmed_id": "35714395\n32322400\n32154135\n32151335\n32058570\n32215598\n32409520\n32304114\n32151335\n32151334\n32035511\n32711688\n32711687\n33133091\n33973182\n34033342\n35257193\n35022588\n34389291\n34536988\n32873575\n32728006\n34302772\n32570284\n32479682\n34187688\n33246205\n32437755\n33828228\n32444569\n35236661",
    "results": "During the study period, 133 (13.7%) mothers were positive for SARS-CoV-2. Among the 35 pregnant women with COVID-19 symptoms (26.3%), cough was the most common symptom, present in half of the cases. Four of them have progressed to critical pneumonia requiring transfer to intensive care unit. The neonates from mothers with positive SARS-CoV-2-RT-PCR, were routinely tested for COVID-19 within the first 24\u00a0h after labor, and 3 other newborns tested in the presence of symptoms. There was no significant difference between the two groups with respect to preterm birth, meconium-stained amniotic fluid distress, and neonatal asphyxia. Most infants were breastfed at birth, regardless of their mothers' COVID-19 status. In COVID-19-positive pregnant women admitted to intensive care unit, the proportion of preterm births (OR=12.5 [1.7-90.5]), fetal death in utero (OR=25.9 [2.2-305]) and admission in neonatal intensive care unit admission (OR=13.4 [3.0-60]), appeared higher than the controls. No maternal deaths were recorded.",
    "title": "Neonatal outcomes related to maternal SARS-CoV-2 infection in French Guiana: A case-control study.",
    "xml": "<Element 'PubmedArticle' at 0x788503009d50>"
}