{
    "abstract": "Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca\nTo test the role of these Orai1 channels in the cardiac pathophysiology, a transgenic mouse was generated with cardiomyocyte-specific expression of an ion pore-disruptive Orai1\nAdult mice subjected to transverse aortic constriction (TAC) developed cardiac hypertrophy and reduced ventricular function associated with increased Orai1 expression and Orai1-dependent SOCE (assessed by Mn\nThe findings suggest a key role of cardiac Orai1 channels and the potential for Orai1 channel inhibitors as inotropic therapies for maintaining contractility reserve after hypertrophic stress.",
    "authors": [
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Fiona",
            "initials": "F",
            "lastname": "Bartoli"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Marc A",
            "initials": "MA",
            "lastname": "Bailey"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Baptiste",
            "initials": "B",
            "lastname": "Rode"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Philippe",
            "initials": "P",
            "lastname": "Mateo"
        },
        {
            "affiliation": "Inserm, UMR-S 999, Universit\u00e9 Paris-Saclay, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France (F.A., C.R.M.).",
            "firstname": "Fabrice",
            "initials": "F",
            "lastname": "Antigny"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Kaveen",
            "initials": "K",
            "lastname": "Bedouet"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Pascale",
            "initials": "P",
            "lastname": "Gerbaud"
        },
        {
            "affiliation": "School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).",
            "firstname": "Rajendra",
            "initials": "R",
            "lastname": "Gosain"
        },
        {
            "affiliation": "School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).",
            "firstname": "Jeffrey",
            "initials": "J",
            "lastname": "Plante"
        },
        {
            "affiliation": "School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).",
            "firstname": "Katherine",
            "initials": "K",
            "lastname": "Norman"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Susana",
            "initials": "S",
            "lastname": "Gomez"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Florence",
            "initials": "F",
            "lastname": "Lefebvre"
        },
        {
            "affiliation": "Inserm, UMR-S 999, Universit\u00e9 Paris-Saclay, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France (F.A., C.R.M.).",
            "firstname": "Catherine",
            "initials": "C",
            "lastname": "Rucker-Martin"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Justin F X",
            "initials": "JFX",
            "lastname": "Ainscough"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Mark T",
            "initials": "MT",
            "lastname": "Kearney"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Alexander-Francisco",
            "initials": "AF",
            "lastname": "Bruns"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Jian",
            "initials": "J",
            "lastname": "Shi"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Hollie L",
            "initials": "HL",
            "lastname": "Appleby"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Richard S",
            "initials": "RS",
            "lastname": "Young"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Heba M",
            "initials": "HM",
            "lastname": "Shawer"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "Marjolaine",
            "initials": "M",
            "lastname": "Debant"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Ana-Maria",
            "initials": "AM",
            "lastname": "Gomez"
        },
        {
            "affiliation": "Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).",
            "firstname": "David J",
            "initials": "DJ",
            "lastname": "Beech"
        },
        {
            "affiliation": "School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).",
            "firstname": "Richard",
            "initials": "R",
            "lastname": "Foster"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Jean-Pierre",
            "initials": "JP",
            "lastname": "Benitah"
        },
        {
            "affiliation": "Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Universit\u00e9 Paris-Saclay, Ch\u00e2tenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).",
            "firstname": "Jessica",
            "initials": "J",
            "lastname": "Sabourin"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/CIRCULATIONAHA.118.038891",
    "journal": "Circulation",
    "keywords": [
        "ORAI1 protein",
        "calcium",
        "cardiomyocytes",
        "hypertrophy",
        "ventricular function"
    ],
    "methods": null,
    "publication_date": "2020-01-08",
    "pubmed_id": "31906693\n28900930\n21252153\n23890109\n20138887\n22302996\n25249026\n28900931\n22079292\n27129253\n24135962\n26269433\n29807359\n19648266\n29386203\n24585777\n26469693\n12843441\n10052353\n22641696\n26956484\n15829561\n28019664\n25968337\n28592415\n25213556\n29634917\n26825122\n19487696\n20434768\n26069213\n25047165\n26241845\n24492416\n25587190\n29642009\n17099778\n17082763\n20351294\n25901070\n26936863\n12124218\n24713463\n15158119\n25433371\n25008120\n16735677\n9705309\n25117468\n27426917\n28126709",
    "results": "Adult mice subjected to transverse aortic constriction (TAC) developed cardiac hypertrophy and reduced ventricular function associated with increased Orai1 expression and Orai1-dependent SOCE (assessed by Mn",
    "title": "Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca",
    "xml": "<Element 'PubmedArticle' at 0x788502dfd2b0>"
}