{
    "abstract": "Bariatric surgery is very efficacious in treating severe obesity. However, its effect on menstruation and ovulation is currently unknown. The purpose of this study was to assess the effect of gastric sleeve resection (GSR) on menstrual pattern in women with stages III-IV obesity and ovulatory dysfunction compared with conventional management.\nThis was a prospective, multicentre, non-randomized trial, in premenopausal women, who fulfilled the criteria for gastric sleeve resection (GSR). Both women with and without polycystic ovary syndrome (PCOS) were evaluated at 3, 6, 9, 12 and 15\u00a0months post-surgery.\nMenstrual cycle irregularities were identified in 122 severely obese women (60 with PCOS; 62 without PCOS). The % total weight loss was greater with GSR than with conventional management (33.4% vs. 3.6% in PCOS; 24.8% vs. 3.6% in non-PCOS, respectively). Intermenstrual interval was shortened towards normal length (\u2264\u200935\u00a0days) both in PCOS and non-PCOS GSR groups, by the 6th and 12th post-surgical month, respectively. Furthermore, ovulation at 6\u00a0months was achieved in 63.6% of PCOS and 45% of non-PCOS subjects post-GSR, which was higher than in controls (11.1% and 13.6%, respectively; p\u2009<\u20090.05). This percentage rose to 75.7% and 81.8% at 12 and 15\u00a0months in PCOS, respectively, but not in the non-PCOS group (55% and 52.5%, respectively; p\u2009<\u20090.05).\nWeight reduction after GSR improved menstrual irregularity towards normality in women with severe obesity. Ovulation dysfunction was also resumed in more than half of these patients at 6-15\u00a0months. These effects were more evident in women with PCOS.",
    "authors": [
        {
            "affiliation": "Institute of Pediatrics, Obstetrics and Gynecology of the Academy of Medical Sciences of Ukraine, 8 Platon Mayboroda St, Kyiv, 04050, Ukraine.",
            "firstname": "Tetiana",
            "initials": "T",
            "lastname": "Tatarchuk"
        },
        {
            "affiliation": "Center for Innovative Medical Technologies, Academy of Sciences of Ukraine, 22 Voznesenskiy Uzviz St, Kyiv, 04053, Ukraine.",
            "firstname": "Ivan",
            "initials": "I",
            "lastname": "Todurov"
        },
        {
            "affiliation": "Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. pan.anagnostis@gmail.com.",
            "firstname": "Panagiotis",
            "initials": "P",
            "lastname": "Anagnostis"
        },
        {
            "affiliation": "Institute of Pediatrics, Obstetrics and Gynecology of the Academy of Medical Sciences of Ukraine, 8 Platon Mayboroda St, Kyiv, 04050, Ukraine.",
            "firstname": "Tetiana",
            "initials": "T",
            "lastname": "Tutchenko"
        },
        {
            "affiliation": "Department of Obstetrics, Gynecology and Perinatology, P.L. Shupik National Healthcare University of Ukraine, Kyiv, Ukraine.",
            "firstname": "Natalia",
            "initials": "N",
            "lastname": "Pedachenko"
        },
        {
            "affiliation": "Institute of Pediatrics, Obstetrics and Gynecology of the Academy of Medical Sciences of Ukraine, 8 Platon Mayboroda St, Kyiv, 04050, Ukraine.",
            "firstname": "Marina",
            "initials": "M",
            "lastname": "Glamazda"
        },
        {
            "affiliation": "Institute of Pediatrics, Obstetrics and Gynecology of the Academy of Medical Sciences of Ukraine, 8 Platon Mayboroda St, Kyiv, 04050, Ukraine.",
            "firstname": "Natalia",
            "initials": "N",
            "lastname": "Koseii"
        },
        {
            "affiliation": "Institute of Pediatrics, Obstetrics and Gynecology of the Academy of Medical Sciences of Ukraine, 8 Platon Mayboroda St, Kyiv, 04050, Ukraine.",
            "firstname": "Svetlana",
            "initials": "S",
            "lastname": "Regeda"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
    "doi": "10.1007/s11695-021-05820-0\n10.1053/j.gastro.2016.12.048\n10.1155/2020/7453786\n10.2147/DMSO.S280146\n10.1007/s00464-020-07555-y\n10.1016/j.jamcollsurg.2005.03.022\n10.1038/ijo.2012.159\n10.1159/000511023\n10.1111/j.1365-2265.1992.tb02295.x\n10.1186/s12958-018-0336-z\n10.1016/j.mce.2009.09.026\n10.1055/s-0032-1328879\n10.1080/0167482X.2017.1403418\n10.1136/bmj.g3961\n10.1016/j.amjsurg.2015.10.012\n10.1093/humupd/dmx012\n10.1007/s11695-017-2614-9\n10.1007/s11695-013-1079-8\n10.1111/obr.12927\n10.1515/CCLM.2010.303\n10.1093/humupd/dmz011\n10.1016/j.soard.2019.03.032\n10.1016/j.lfs.2019.116940\n10.1152/ajpendo.00458.2001\n10.1210/jcem-60-6-1174\n10.2174/0929866527666200505214555\n10.1016/j.metabol.2014.08.004\n10.1155/2018/7965071\n10.1177/0003319712455686\n10.2174/138945010790030992\n10.1055/a-1129-6785\n10.1038/mp.2015.153\n10.1177/0003319720914493\n10.1093/humrep/dey032\n10.1080/09513590.2018.1559285\n10.1111/cen.13358\n10.1007/s10815-018-1196-3\n10.1007/s11695-019-04093-y",
    "journal": "Obesity surgery",
    "keywords": [
        "Gastric sleeve resection",
        "Oligomenorrhea",
        "Ovulation",
        "PCOS"
    ],
    "methods": null,
    "publication_date": "2021-11-25",
    "pubmed_id": "34817794\n32500010\n10999821",
    "results": "Menstrual cycle irregularities were identified in 122 severely obese women (60 with PCOS; 62 without PCOS). The % total weight loss was greater with GSR than with conventional management (33.4% vs. 3.6% in PCOS; 24.8% vs. 3.6% in non-PCOS, respectively). Intermenstrual interval was shortened towards normal length (\u2264\u200935\u00a0days) both in PCOS and non-PCOS GSR groups, by the 6th and 12th post-surgical month, respectively. Furthermore, ovulation at 6\u00a0months was achieved in 63.6% of PCOS and 45% of non-PCOS subjects post-GSR, which was higher than in controls (11.1% and 13.6%, respectively; p\u2009<\u20090.05). This percentage rose to 75.7% and 81.8% at 12 and 15\u00a0months in PCOS, respectively, but not in the non-PCOS group (55% and 52.5%, respectively; p\u2009<\u20090.05).",
    "title": "The Effect of Gastric Sleeve Resection on Menstrual Pattern and Ovulation in Premenopausal Women with Classes III-IV Obesity.",
    "xml": "<Element 'PubmedArticle' at 0x788502979da0>"
}