{
    "abstract": "Inflammation, oxidative damage, and adenosine triphosphate (ATP) depletion play a role in the pathogenesis of cisplatin (CIS)-induced oral mucositis.\nThe purpose of this research is to examine the impact of ATP against potential oral mucositis development in cisplatin-treated rats. Methodology All rats were randomly assigned to four groups, namely healthy control group (HG), ATP group (ATPG), Cisplatin group (CISG), and ATP + Cisplatin group (ATCS). Firstly, ATP 4 mg/kg was administered via intraperitoneal injection (IP) to both ATPG and ATCS groups. The same volume of normal saline was injected into HG and CISG groups. After 1 h, cisplatin 5 mg/kg was administered via IP to CISG and ATCS groups. The drugs were taken 1x1 for 7 d. Later, tongue tissues were collected from all groups. Biochemical, macroscopic, and histopathological examinations were performed on all tissues.\nATP inhibited cisplatin-induced oxidative damage and pro-inflammatory cytokines levels in tongue tissue. In the CIS group, a significant number of distinct sulcus formations were found in the apex and corpus, as well as a few ulcer foci in the corpus, significant papilla loss, and bleeding. Meanwhile, in the ATP group, a similar appearance to healthy tissue was observed. Histopathologically, it was determined that in cisplatin-aggravated tongue tissue damage, filiform papillae decreased when ATP was administered, and the arrangement and structures of the epithelium, blood capillaries, muscle groups, and adipose cell groups were normal.\nOral mucositis caused by cisplatin is alleviated by ATP. These findings may be useful for developing new therapeutic approaches to prevent or treat mucositis, a side effect so severe that can lead to treatment discontinuation.",
    "authors": [
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Medicine, Department of Ear, Nose, Throat Diseases, Erzincan, Turkey.",
            "firstname": "Ismail",
            "initials": "I",
            "lastname": "Salcan"
        },
        {
            "affiliation": "Independent researcher, Istanbul, Turkey.",
            "firstname": "Muhammed",
            "initials": "M",
            "lastname": "Dilber"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Health Sciences, Department of Internal Medicine Nursing, Erzincan, Turkey.",
            "firstname": "Zeynep",
            "initials": "Z",
            "lastname": "Suleyman"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Vocational School of Health Services, Pharmacy Services Program, Erzincan, Turkey.",
            "firstname": "Nurinisa",
            "initials": "N",
            "lastname": "Yucel"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Medicine, Department of Public Health, Erzincan, Turkey.",
            "firstname": "Sara",
            "initials": "S",
            "lastname": "Salcan"
        },
        {
            "affiliation": "Kozlu State Hospital, Department of Ear, Nose, Throat Diseases, Batman, Turkey.",
            "firstname": "Sefa",
            "initials": "S",
            "lastname": "Kesan"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Medicine, Department of Histology and Embryology, 24100, Erzincan, Turkey.",
            "firstname": "Gulce Naz",
            "initials": "GN",
            "lastname": "Yazici"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Oral and Dental Health Education and Research Hospital, Erzincan, Turkey.",
            "firstname": "Fatih",
            "initials": "F",
            "lastname": "Celik"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Dentistry, Department of Endodontics, Erzincan, Turkey.",
            "firstname": "Merve",
            "initials": "M",
            "lastname": "Koseturk"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Medicine, Department of Pharmacology, 24100, Erzincan, Turkey.",
            "firstname": "Nurdan",
            "initials": "N",
            "lastname": "Alcan Alp"
        },
        {
            "affiliation": "Erzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Biochemistry, 24100, Erzincan, Turkey.",
            "firstname": "Halis",
            "initials": "H",
            "lastname": "Suleyman"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1590/1678-7757-2025-0007\n10.1016/j.ejphar.2014.07.025\n10.1016/j.tox.2023.153516\n10.1039/c8dt90088d\n10.1590/s1679-45082018rw4007\n10.30621/jbachs.1199539\n10.1186/s13046-020-01715-7\n10.1104/pp.010999\n10.1371/journal.pone.0135083\n10.1080/14620316.2000.11511231\n10.4196/kjpp.2021.25.1.69\n10.1080/15569527.2018.1482494\n10.1016/0009-8981(91)90067-m\n10.5152/tao.2020.4733\n10.3390/ijms241914574\n10.1016/j.heliyon.2020.e03688\n10.3390/ijms23094863\n10.21474/IJAR01/6024\n10.1016/j.ab.2016.10.021\n10.1089/jmf.2019.0235\n10.1016/j.cyto.2021.155506\n10.4161/cbt.7.7.6207\n10.1093/rheumatology/keg452\n10.1016/j.tox.2019.152281\n10.1016/j.tips.2021.10.010\n10.1126/scisignal.256pe\n10.1038/sj.bjp.0703134\n10.1096/fj.99-0508com\n10.3390/pharmaceutics12040304\n10.5644/ama2006-124.422",
    "journal": "Journal of applied oral science : revista FOB",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-03-26",
    "pubmed_id": "40136224\n25058905\n37087063\n29808879\n29694618\n33028357\n11950976\n26247588\n31985968\n33361539\n29865906\n2029780\n32313889\n37834021\n32368638\n35563254\n27789233\n10912697\n32423279\n33846070\n33351407\n18535404\n12867573\n31445075\n34776241\n19193605\n10696089\n11023991\n8906843\n16339566\n32230975\n38407085",
    "results": "ATP inhibited cisplatin-induced oxidative damage and pro-inflammatory cytokines levels in tongue tissue. In the CIS group, a significant number of distinct sulcus formations were found in the apex and corpus, as well as a few ulcer foci in the corpus, significant papilla loss, and bleeding. Meanwhile, in the ATP group, a similar appearance to healthy tissue was observed. Histopathologically, it was determined that in cisplatin-aggravated tongue tissue damage, filiform papillae decreased when ATP was administered, and the arrangement and structures of the epithelium, blood capillaries, muscle groups, and adipose cell groups were normal.",
    "title": "Protective effect of adenosine triphosphate against cisplatin-induced necrotic and degenerative oral mucositis in rats.",
    "xml": "<Element 'PubmedArticle' at 0x7885038f2610>"
}