{
    "abstract": "Limited knowledge exists about prophylactic anticoagulation patterns in patients hospitalized for COVID-19.\nWe conducted a retrospective cohort study using American Heart Association COVID-19 Cardiovascular Disease Registry data from May 2020 to March 2022. We included patients without preexisting indications for or contraindications to anticoagulation, excluding those with missing anticoagulation data. Patients were categorized by the highest anticoagulation dose received. Multilevel logistic regression was used to assess the relationship between anticoagulation use/dose, patient demographics, clinical presentation, in-hospital course, institutional characteristics, and admission date, accounting for hospital clustering. Among 26\u2009775 patients, 4157 (16%) received no anticoagulation, 15\u2009617 (58%) low-dose, 3071 (11%) intermediate-dose, and 3930 (15%) full-dose anticoagulation. Significant hospital-level variability occurred for any anticoagulation use (range, 0%-98%; \nIn this large real-world analysis, nearly 1 in 6 patients hospitalized for COVID-19 received no prophylactic anticoagulation. Patient and disease characteristics associated with thrombotic risk and COVID-19 severity correlated with anticoagulation strategy. Importantly, substantial institutional differences emerged, highlighting gaps between clinical practice and guideline recommendations.",
    "authors": [
        {
            "affiliation": "Division of Cardiovascular Medicine Brigham and Women's Hospital Boston MA USA.",
            "firstname": "Mathew S",
            "initials": "MS",
            "lastname": "Lopes"
        },
        {
            "affiliation": "Center for Cardiovascular Analytics, Research, and Data Science (CARDS) Providence Heart Institute Portland OR USA.",
            "firstname": "Hsin-Fang",
            "initials": "HF",
            "lastname": "Li"
        },
        {
            "affiliation": "Institute for Health Metrics and Evaluation, University of Washington Seattle WA USA.",
            "firstname": "Reed J D",
            "initials": "RJD",
            "lastname": "Sorensen"
        },
        {
            "affiliation": "UT Southwestern Medical Center Dallas TX USA.",
            "firstname": "Sandeep",
            "initials": "S",
            "lastname": "Das"
        },
        {
            "affiliation": "Minneapolis Heart Institute Minneapolis MN USA.",
            "firstname": "Steven M",
            "initials": "SM",
            "lastname": "Bradley"
        },
        {
            "affiliation": "UT Southwestern Medical Center Dallas TX USA.",
            "firstname": "James A",
            "initials": "JA",
            "lastname": "de Lemos"
        },
        {
            "affiliation": "Division of Cardiology, Department of Medicine University of Washington Seattle WA USA.",
            "firstname": "Gregory A",
            "initials": "GA",
            "lastname": "Roth"
        },
        {
            "affiliation": "Duke Clinical Research Institute Durham NC USA.",
            "firstname": "Tracy",
            "initials": "T",
            "lastname": "Wang"
        },
        {
            "affiliation": "Division of Cardiovascular Medicine Brigham and Women's Hospital Boston MA USA.",
            "firstname": "Erin A",
            "initials": "EA",
            "lastname": "Bohula"
        },
        {
            "affiliation": "Center for Cardiovascular Analytics, Research, and Data Science (CARDS) Providence Heart Institute Portland OR USA.",
            "firstname": "Ty J",
            "initials": "TJ",
            "lastname": "Gluckman"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/JAHA.123.034186",
    "journal": "Journal of the American Heart Association",
    "keywords": [
        "COVID\u201019",
        "SARS\u2010CoV\u20102",
        "anticoagulation",
        "prophylaxis",
        "registry"
    ],
    "methods": null,
    "publication_date": "2025-03-03",
    "pubmed_id": "40028842",
    "results": null,
    "title": "Patterns of Prophylactic Anticoagulation Among Patients Hospitalized for COVID-19: An Analysis of the American Heart Association COVID-19 Cardiovascular Disease Registry.",
    "xml": "<Element 'PubmedArticle' at 0x7885056a8450>"
}