{
    "abstract": "The 3C-like protease (3CL",
    "authors": [
        {
            "affiliation": "Biotechnology Division, Department of Biology, Istanbul University, Istanbul, T\u00fcrkiye.\nInstitute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, T\u00fcrkiye.",
            "firstname": "Bet\u00fcl",
            "initials": "B",
            "lastname": "Oru\u00e7o\u011flu"
        },
        {
            "affiliation": "Biotechnology Division, Department of Biology, Istanbul University, Istanbul, T\u00fcrkiye.",
            "firstname": "\u0130dil",
            "initials": "\u0130",
            "lastname": "\u00c7etin"
        },
        {
            "affiliation": "Biotechnology Division, Department of Biology, Istanbul University, Istanbul, T\u00fcrkiye.",
            "firstname": "Handan",
            "initials": "H",
            "lastname": "\u015eim\u015fek"
        },
        {
            "affiliation": "Biotechnology Division, Department of Biology, Istanbul University, Istanbul, T\u00fcrkiye.",
            "firstname": "Mehmet",
            "initials": "M",
            "lastname": "Top\u00e7ul"
        },
        {
            "affiliation": "Biotechnology Division, Department of Biology, Istanbul University, Istanbul, T\u00fcrkiye.",
            "firstname": "Mahmut",
            "initials": "M",
            "lastname": "\u00c7al\u0131\u015fkan"
        },
        {
            "affiliation": "Department of Molecular Biology, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, T\u00fcrkiye.\nIstanbul Medeniyet University Science and Advanced Technology Research Center (IMU-BILTAM), Istanbul, T\u00fcrkiye.",
            "firstname": "Cihan",
            "initials": "C",
            "lastname": "Ayd\u0131n"
        },
        {
            "affiliation": "Department of Molecular Biology and Genetics, Koc University, Istanbul, T\u00fcrkiye.\nDepartment of Chemical and Biological Engineering, Koc University, Istanbul, T\u00fcrkiye.",
            "firstname": "I Halil",
            "initials": "IH",
            "lastname": "Kavakl\u0131"
        },
        {
            "affiliation": "Faculty of Pharmacy, Department of Pharmacology, \u0130stanbul University, Istanbul, T\u00fcrkiye.",
            "firstname": "Alper",
            "initials": "A",
            "lastname": "Okyar"
        },
        {
            "affiliation": "Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, T\u00fcrkiye. seref.gul@bezmialem.edu.tr.",
            "firstname": "\u015eeref",
            "initials": "\u015e",
            "lastname": "G\u00fcl"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1038/s41598-025-88388-4",
    "journal": "Scientific reports",
    "keywords": [
        "3CLpro",
        "Candesartan",
        "Drug repurposing",
        "Lumacaftor",
        "SARS-CoV-2",
        "Subgenomic replicon"
    ],
    "methods": null,
    "publication_date": "2025-04-23",
    "pubmed_id": "40263343\n32388537\n33093684\n32272481\n32272481\n36464706\n33895266\n32321856\n34803446\n33795671\n32275855\n32198291\n34663813\n32887884\n33275063\n34347470\n33503819\n32752938\n34851142\n33766889\n33999369\n19047201\n33217430\n21468966\n34531414\n19499576\n8744570\n27819658\n16222654\n28497616\n32541865\n20190787\n21730030\n26700958\n1358431\n22279052\n20847136\n28249963\n33597253\n35126106\n38321448\n35930306\n36625656\n33995989\n34797474\n32942152\n33051297\n33568498",
    "results": null,
    "title": "Identification of potential SARS-CoV-2 inhibitors among well-tolerated drugs using drug repurposing and in vitro approaches.",
    "xml": "<Element 'PubmedArticle' at 0x788505d36890>"
}