{
    "abstract": "To compare the effects of propofol and alfaxalone on respiration in cats.\nRandomized, 'blinded', prospective clinical trial.\nTwenty cats undergoing ovariohysterectomy.\nAfter premedication with medetomidine 0.01\u00a0mg\u00a0kg(-1) intramuscularly and meloxicam 0.3\u00a0mg\u00a0kg(-1) subcutaneously, the cats were assigned randomly into two groups: group A (n\u00a0=\u00a010) were administered alfaxalone 5\u00a0mg\u00a0kg(-1) \u00a0minute(-1) followed by 10\u00a0mg\u00a0kg(-1) \u00a0hour(-1) intravenously (IV) and group P (n\u00a0=\u00a010) were administered propofol 6\u00a0mg\u00a0kg(-1\u00a0) minute(-1) followed by 12\u00a0mg\u00a0kg(-1) hour(-1) IV for induction and maintenance of anaesthesia, respectively. After endotracheal intubation, the tube was connected to a non-rebreathing system delivering 100% oxygen. The anaesthetic maintenance drug rate was adjusted (\u00b1\u00a00.5\u00a0mg\u00a0kg(-1) hour(-1) ) every 5\u00a0minutes according to a scoring sheet based on physiologic variables and clinical signs. If apnoea >\u00a030\u00a0seconds, end-tidal carbon dioxide (Pe'CO2 ) >\u00a07.3 kPa (55\u00a0mmHg) or arterial haemoglobin oxygen saturation (SpO2 )\u00a0<\u00a090% occurred, manual ventilation was provided. Methadone was administered postoperatively. Data were analyzed using independent-samples t-tests, Fisher's exact test, linear mixed-effects models and binomial test.\nManual ventilation was required in two and eight of the cats in group A and P, respectively (p\u00a0=\u00a00.02). Two cats in both groups showed apnoea. Pe'CO2 \u00a0>\u00a07.3 kPa was recorded in zero versus four and SpO2 \u00a0<\u00a090% in zero versus six cats in groups A and P respectively. Induction and maintenance dose rates (mean \u00b1 SD) were 11.6\u00a0\u00b1\u00a00.3\u00a0mg\u00a0kg(-1) and 10.7\u00a0\u00b1\u00a00.8\u00a0mg\u00a0kg(-1) \u00a0hour(-1) for alfaxalone and 11.7\u00a0\u00b1\u00a02.7\u00a0mg\u00a0kg(-1) and 12.4\u00a0\u00b1\u00a00.5\u00a0mg\u00a0kg(-1) hour(-1) for propofol.\nAlfaxalone had less adverse influence on respiration than propofol in cats premedicated with medetomidine. Alfaxalone might be better than propofol for induction and maintenance of anaesthesia when artificial ventilation cannot be provided.",
    "authors": [
        {
            "affiliation": "Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.",
            "firstname": "Ivo",
            "initials": "I",
            "lastname": "Campagna"
        },
        {
            "affiliation": "Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.",
            "firstname": "Andrea",
            "initials": "A",
            "lastname": "Schwarz"
        },
        {
            "affiliation": "Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.",
            "firstname": "Stefanie",
            "initials": "S",
            "lastname": "Keller"
        },
        {
            "affiliation": "Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.",
            "firstname": "Regula",
            "initials": "R",
            "lastname": "Bettschart-Wolfensberger"
        },
        {
            "affiliation": "Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.",
            "firstname": "Martina",
            "initials": "M",
            "lastname": "Mosing"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.",
    "doi": "10.1111/vaa.12231",
    "journal": "Veterinary anaesthesia and analgesia",
    "keywords": [
        "continuous rate infusion",
        "feline",
        "respiration",
        "total intravenous anaesthesia",
        "ventilation"
    ],
    "methods": null,
    "publication_date": "2014-10-14",
    "pubmed_id": "25308500",
    "results": "Manual ventilation was required in two and eight of the cats in group A and P, respectively (p\u00a0=\u00a00.02). Two cats in both groups showed apnoea. Pe'CO2 \u00a0>\u00a07.3 kPa was recorded in zero versus four and SpO2 \u00a0<\u00a090% in zero versus six cats in groups A and P respectively. Induction and maintenance dose rates (mean \u00b1 SD) were 11.6\u00a0\u00b1\u00a00.3\u00a0mg\u00a0kg(-1) and 10.7\u00a0\u00b1\u00a00.8\u00a0mg\u00a0kg(-1) \u00a0hour(-1) for alfaxalone and 11.7\u00a0\u00b1\u00a02.7\u00a0mg\u00a0kg(-1) and 12.4\u00a0\u00b1\u00a00.5\u00a0mg\u00a0kg(-1) hour(-1) for propofol.",
    "title": "Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats.",
    "xml": "<Element 'PubmedArticle' at 0x788504b97010>"
}