{
    "abstract": "Chronic inflammation and oxidative stress in the diabetic microenvironment often hinder the healing of bone defects. Metformin (MET), the first-line diabetes medication, was shown to alter macrophage polarization toward an anti-inflammatory M2 phenotype, while simultaneously suppressing excessive reactive oxygen species (ROS) generation. Strontium-doped mesoporous bioactive glasses (SrMBG) also showed promising benefits in promoting bone regeneration. Aiming to improve the diabetic immune microenvironment within bone defects, in this study we loaded SrMBG mesopores with increasing amounts of MET. MET-loaded SrMBG (MET/SrMBG) extracts promoted macrophage differentiation toward the M2 phenotype and reduced ROS production ",
    "authors": [
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.\nDepartment of Pediatric Dentistry, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, China.\nKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, Sichuan, China.",
            "firstname": "Qing",
            "initials": "Q",
            "lastname": "Ye"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.",
            "firstname": "Min",
            "initials": "M",
            "lastname": "Zhang"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.",
            "firstname": "Qianrui",
            "initials": "Q",
            "lastname": "Li"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. yuanhe-06@163.com.",
            "firstname": "Lingling",
            "initials": "L",
            "lastname": "Jia"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. yuanhe-06@163.com.",
            "firstname": "Yuan",
            "initials": "Y",
            "lastname": "Gao"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. yuanhe-06@163.com.",
            "firstname": "He",
            "initials": "H",
            "lastname": "Yuan"
        },
        {
            "affiliation": "State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.",
            "firstname": "Jiyao",
            "initials": "J",
            "lastname": "Li"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1039/d4tb01778a",
    "journal": "Journal of materials chemistry. B",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-02-04",
    "pubmed_id": "39903083",
    "results": null,
    "title": "Regulation of the diabetic immune microenvironment by metformin-loaded strontium-doped mesoporous bioactive glass facilitates bone regeneration.",
    "xml": "<Element 'PubmedArticle' at 0x7885023fea70>"
}