{
    "abstract": "Post-transplantation tracking of pancreatic islets is a prerequisite for advancing cell therapy to treat type 1 diabetes. Magnetic resonance imaging (MRI) has emerged as a safe and non-invasive technique for visualizing cells in clinical applications. In this study, we proposed a novel MRI contrast agent formulation by encapsulating iron oxide nanoparticles (IONPs) in poly(lactic-co-glycolic acid) (PLGA) particles functionalized with a tissue adhesive polydopamine (PD) layer (IONP-PLGA-PD MS). Intriguingly, our particles facilitated efficient and robust labeling through a one-step process, allowing for the incorporation of a substantial amount of IONPs without detrimental impacts on the viability and functionality of pancreatic islets. The MRI signals emanating from islets labeled using our particles were found to be stable over 30\u00a0days in vitro and 60\u00a0days when transplanted under kidney capsules of diabetic mice. These results suggest that our approach provides a potential platform for monitoring the fate of pancreatic islets after transplantation.",
    "authors": [
        {
            "affiliation": "College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea.",
            "firstname": "Phuong",
            "initials": "P",
            "lastname": "Le Tran"
        },
        {
            "affiliation": "College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea.",
            "firstname": "Tung Thanh",
            "initials": "TT",
            "lastname": "Pham"
        },
        {
            "affiliation": "R&D Center, Cellstormer, Suwon, Gyeonggi 16677, Republic of Korea.",
            "firstname": "Han Sin",
            "initials": "HS",
            "lastname": "Lee"
        },
        {
            "affiliation": "Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06355, Republic of Korea.",
            "firstname": "Soojung",
            "initials": "S",
            "lastname": "Hahn"
        },
        {
            "affiliation": "College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.",
            "firstname": "Jeong Uk",
            "initials": "JU",
            "lastname": "Choi"
        },
        {
            "affiliation": "Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.",
            "firstname": "Jae Hyeon",
            "initials": "JH",
            "lastname": "Kim"
        },
        {
            "affiliation": "State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.",
            "firstname": "Hu-Lin",
            "initials": "HL",
            "lastname": "Jiang"
        },
        {
            "affiliation": "College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea. Electronic address: ysimmyung@skku.edu.",
            "firstname": "Simmyung",
            "initials": "S",
            "lastname": "Yook"
        },
        {
            "affiliation": "College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea. Electronic address: jeeheon@skku.edu.",
            "firstname": "Jee-Heon",
            "initials": "JH",
            "lastname": "Jeong"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2023 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jconrel.2023.10.008",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "keywords": [
        "Contrast agent",
        "Islet transplantation",
        "MRI tracking",
        "Polymeric microspheres",
        "Type 1 diabetes",
        "iron oxide nanoparticles"
    ],
    "methods": null,
    "publication_date": "2023-10-10",
    "pubmed_id": "37813125",
    "results": null,
    "title": "Magnetic resonance imaging of pancreatic islets using tissue-adhesive particles containing iron oxide nanoparticles.",
    "xml": "<Element 'PubmedArticle' at 0x78850655c7c0>"
}