{
    "abstract": "The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients.\nA case-control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT.\nCompared to the controls, cases had significantly higher 11-KT (20.81 \u00b1 3.53 vs. 15.83 \u00b1 2.67 nmol/L, \nIn conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.",
    "authors": [
        {
            "affiliation": "Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India.",
            "firstname": "Nirmal",
            "initials": "N",
            "lastname": "Kumar"
        },
        {
            "affiliation": "Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India.",
            "firstname": "Neera",
            "initials": "N",
            "lastname": "Sharma"
        },
        {
            "affiliation": "Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India.",
            "firstname": "Smita",
            "initials": "S",
            "lastname": "Roy"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, ABVIMS and Dr. RML Hospital, New Delhi, India.",
            "firstname": "Indu",
            "initials": "I",
            "lastname": "Chawla"
        },
        {
            "affiliation": "Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India.",
            "firstname": "Lokesh Kumar",
            "initials": "LK",
            "lastname": "Sharma"
        }
    ],
    "conclusions": "In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.",
    "copyrights": "Copyright: \u00a9 2025 Advanced Biomedical Research.",
    "doi": "10.4103/abr.abr_262_23",
    "journal": "Advanced biomedical research",
    "keywords": [
        "Androgens",
        "dehydroepiandrosterone",
        "diagnosis",
        "dihydrotestosterone",
        "insulin",
        "ovary",
        "sex hormone-binding globulin",
        "testosterone"
    ],
    "methods": null,
    "publication_date": "2025-04-11",
    "pubmed_id": "40213586\n31466345\n27510637\n30059968\n30052961\n24713888\n35140526\n29453202\n14711538\n30012903\n34951635\n27901631\n28157253\n30058676\n28178574\n18722607\n17132756\n26964728\n25595199",
    "results": "Compared to the controls, cases had significantly higher 11-KT (20.81 \u00b1 3.53 vs. 15.83 \u00b1 2.67 nmol/L, ",
    "title": "A Case-Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS).",
    "xml": "<Element 'PubmedArticle' at 0x788504d95120>"
}