{
    "abstract": "Osteoporosis can increase the risk of fracture in elderly patients, and insufficient control affects quality of life. Rikkunshi-To (RKT) has been prescribed for elderly patients to improve gastrointestinal function. We postulated that RKT has preventive potential for the development of osteoporosis. Thus, we developed a simple method to evaluate osteoporosis using a continuous series of X-ray images of femurs in mice, and investigated the effects of RKT on the development of osteoporosis in these mice. Male senescence-accelerated mouse strain P6 (SAMP6) mice, a model of senile osteoporosis in humans, were fed diets with or without RKT (1%). We collected X-ray images of the whole body of each mouse weekly and measured the ratio of cortical thickness of the femur (C/F index). The C/F index in SAMP6 mice fed the normal diet was increased between 50 and 80 days old, but it was significantly decreased after 120 days old. On the other hand, the C/F index in SAMP6 mice fed the RKT diet was increased between 50 and 80 days old; however, it remained unchanged throughout the experimental period. We also confirmed that the C/F index in SAMP6 mice fed the RKT diet suddenly decreased on the replacement of the RKT diet with a normal diet, suggesting that we can collect data related to a series of continuous changes in bone mass, and that RKT is useful for the prevention of osteoporosis.",
    "authors": [
        {
            "affiliation": "Department of Radiological Sciences, Faculty of Health Sciences, Morinomiya University of Medical Sciences, 1-26-16 Nanko-Kita, Suminoe-Ku, Osaka 559-8611, Japan.",
            "firstname": "Kouichi",
            "initials": "K",
            "lastname": "Yamamoto"
        },
        {
            "affiliation": "Department of Radiological Sciences, Faculty of Health Sciences, Morinomiya University of Medical Sciences, 1-26-16 Nanko-Kita, Suminoe-Ku, Osaka 559-8611, Japan.",
            "firstname": "Keiko",
            "initials": "K",
            "lastname": "Yamamoto"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/life15040557\n10.1038/s41413-022-00219-8\n10.1007/s00198-022-06454-3\n10.1016/j.jsbmb.2013.09.008\n10.1097/01.NPR.0000000000000090\n10.1080/14656566.2018.1428559\n10.1007/s00535-013-0896-9\n10.1089/acm.2016.0233\n10.1002/ptr.5001\n10.1377/hlthaff.2011.0233\n10.3390/medicina58121765\n10.1016/0047-6374(81)90084-1\n10.1016/j.exger.2009.09.009\n10.14670/HH-19.677\n10.1016/s0197-4580(99)00008-1\n10.1016/j.jphs.2022.08.001\n10.1016/j.jphs.2018.05.003\n10.1016/j.rcl.2022.02.003\n10.1177/03000605241274576\n10.1007/s40618-014-0074-9\n10.1148/radiol.241339\n10.1007/s10916-023-02030-2\n10.1007/s00223-017-0238-7\n10.1007/s00774-003-0471-1\n10.1016/j.bone.2004.03.027\n10.1359/JBMR.050307\n10.1359/jbmr.2001.16.9.1665\n10.1002/jbm4.10807\n10.1089/ten.tec.2015.0383\n10.1053/j.gastro.2008.02.078\n10.2174/138161212803216933\n10.1152/japplphysiol.00441.2007\n10.1002/jbt.22832\n10.5142/jgr.2013.37.261\n10.3390/nu12051383\n10.1051/bmdcn/2019090208\n10.3389/fphar.2019.01344\n10.1017/S1368980019004828\n10.4103/0976-0105.177703",
    "journal": "Life (Basel, Switzerland)",
    "keywords": [
        "Rikkunshi-To",
        "SAMP6 mice",
        "X-ray image",
        "cortical bone",
        "femur",
        "osteoporosis"
    ],
    "methods": null,
    "publication_date": "2025-04-26",
    "pubmed_id": "40283112\n35851054\n35687123\n24176761\n37643140\n29350069\n24535455\n27996295\n23674260\n22147865\n36556967\n7311623\n19815059\n15168327\n10537019\n36055750\n29914799\n35672087\n39225007\n24737214\n38916509\n38217829\n28197643\n15108062\n15268893\n15940361\n11547836\n38130759\n26956416\n18439428\n22632863\n18174393\n34028927\n24198650\n32408635\n31124454\n31824310\n32513347\n27057123",
    "results": null,
    "title": "Prevention of Osteoporosis in SAMP6 Mice by Rikkunshi-To: Japanese Kampo Medicine.",
    "xml": "<Element 'PubmedArticle' at 0x788503b0f5b0>"
}