{
    "abstract": "Cerebral vascular occlusion is a serious condition that can lead to stroke and permanent neurological damage due to insufficient oxygen and nutrients reaching brain tissue. Early diagnosis and accurate segmentation are critical for effective treatment planning. Due to its high soft tissue contrast, Magnetic Resonance Imaging (MRI) is commonly used for detecting these occlusions such as ischemic stroke. However, challenges such as low contrast, noise, and heterogeneous lesion structures in MRI images complicate manual segmentation and often lead to misinterpretations. As a result, deep learning-based Computer-Aided Diagnosis (CAD) systems are essential for faster and more accurate diagnosis and treatment methods, although they can sometimes face challenges such as high computational costs and difficulties in segmenting small or irregular lesions. This study proposes a novel U-Net architecture enhanced with ConvNeXtV2 blocks and GRN-based Multi-Layer Perceptrons (MLP) to address these challenges in cerebral vascular occlusion segmentation. This is the first application of ConvNeXtV2 in this domain. The proposed model significantly improves segmentation accuracy, even in low-contrast regions, while maintaining high computational efficiency, which is crucial for real-world clinical applications. To reduce false positives and improve overall accuracy, small lesions (\u22645 pixels) were removed in the preprocessing step with the support of expert clinicians. Experimental results on the ISLES 2022 dataset showed superior performance with an Intersection over Union (IoU) of 0.8015 and a Dice coefficient of 0.8894. Comparative analyses indicate that the proposed model achieves higher segmentation accuracy than existing U-Net variants and other methods, offering a promising solution for clinical use.",
    "authors": [
        {
            "affiliation": "Department of Radiology, University of Health Sciences, Van Education and Research Hospital, 65000 Van, Turkey. Electronic address: suat.ince@saglik.gov.tr.",
            "firstname": "Suat",
            "initials": "S",
            "lastname": "Ince"
        },
        {
            "affiliation": "Department of Computer Engineering, Faculty of Engineering, Igdir University, 76000 Igdir, Turkey. Electronic address: ismail.kunduracioglu@igdir.edu.tr.",
            "firstname": "Ismail",
            "initials": "I",
            "lastname": "Kunduracioglu"
        },
        {
            "affiliation": "Department of Informatics and Computer Systems, College of Computer Science, King Khalid University, Abha 61421, Saudi Arabia. Electronic address: akafeer@kku.edu.sa.",
            "firstname": "Ali",
            "initials": "A",
            "lastname": "Algarni"
        },
        {
            "affiliation": "Department of Neurology, University of Health Sciences, Van Education and Research Hospital, 65000 Van, Turkey. Electronic address: bilal.bayram@saglik.gov.tr.",
            "firstname": "Bilal",
            "initials": "B",
            "lastname": "Bayram"
        },
        {
            "affiliation": "Department of Computer Engineering, Faculty of Engineering, Igdir University, 76000 Igdir, Turkey; Department of Electronics and Information Technologies, Faculty of Architecture and Engineering, Nakhchivan State University, AZ 7012 Nakhchivan, Azerbaijan. Electronic address: ishakpacal@igdir.edu.tr.",
            "firstname": "Ishak",
            "initials": "I",
            "lastname": "Pacal"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.neuroscience.2025.04.010",
    "journal": "Neuroscience",
    "keywords": [
        "Brain stroke diagnosis",
        "Deep learning",
        "Health",
        "Medical image processing",
        "U-Net"
    ],
    "methods": null,
    "publication_date": "2025-04-10",
    "pubmed_id": "40204150",
    "results": null,
    "title": "Deep learning for cerebral vascular occlusion segmentation: A novel ConvNeXtV2 and GRN-integrated U-Net framework for diffusion-weighted imaging.",
    "xml": "<Element 'PubmedArticle' at 0x78850585c3b0>"
}