{
    "abstract": "Overcoming the challenges associated with brain-targeted drug delivery involves addressing both the limited biodistribution of drugs and microcirculation issues that hinder their accumulation in brain lesions. In this study, we propose a comprehensive strategy leveraging vinpocetine, a compound known to enhance cerebral blood flow (CBF), to improve drug delivery to the brain. Initially, the pre-administration of vinpocetine in the form of a microemulsion significantly enhances nanomedicine uptake into the brain by selectively boosting CBF. This creates a more favorable environment for drug distribution while also mitigating chemotherapy-induced cerebrovascular accidents. Building upon this, the use of vinpocetine as a targeting ligand for liposomes or lipid nanoparticles, compared to typical brain-targeting ligands (GSH, Apamin, and Angiopep-2), not only significantly improves drug distribution in the brain but also selectively targets glioma regions and maintains excellent immunocompatibility. Expanding on these findings, the direct conjugation of vinpocetine with therapeutic compounds leads to superior brain accumulation and enhanced antitumor efficacy, thereby extending its therapeutic potential. These results highlight the broad applicability of vinpocetine-based strategies for achieving efficient and precise brain-targeted drug delivery, offering promising prospects for treating a range of central nervous system disorders.",
    "authors": [
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.",
            "firstname": "Zhongyi",
            "initials": "Z",
            "lastname": "Ma"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.",
            "firstname": "Xinlong",
            "initials": "X",
            "lastname": "Liu"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.",
            "firstname": "Xinyu",
            "initials": "X",
            "lastname": "Xie"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.",
            "firstname": "Yike",
            "initials": "Y",
            "lastname": "Fang"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.",
            "firstname": "Dingxi",
            "initials": "D",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.",
            "firstname": "Chen",
            "initials": "C",
            "lastname": "Zhao"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.",
            "firstname": "Pingrong",
            "initials": "P",
            "lastname": "Li"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Fu"
        },
        {
            "affiliation": "ChongQing TongLiang District Hospital of Traditional Chinese Medicine, Chongqing 402560, China.",
            "firstname": "Lianghong",
            "initials": "L",
            "lastname": "Ye"
        },
        {
            "affiliation": "State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: gaoyuan321@fmmu.edu.cn.",
            "firstname": "Yuan",
            "initials": "Y",
            "lastname": "Gao"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; Key Laboratory of Drug-Targeting and Drug Delivery System, Ministry of Education, Chengdu 610041, China. Electronic address: wushuangwu@swu.edu.cn.",
            "firstname": "Shuang",
            "initials": "S",
            "lastname": "Wu"
        },
        {
            "affiliation": "Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: chongli@swu.edu.cn.",
            "firstname": "Chong",
            "initials": "C",
            "lastname": "Li"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jconrel.2025.113768",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "keywords": [
        "CNS disease",
        "Cerebral blood flow",
        "Targeted delivery",
        "Vinpocetine"
    ],
    "methods": null,
    "publication_date": "2025-04-25",
    "pubmed_id": "40274071",
    "results": null,
    "title": "Vinpocetine-mediated multidimensional active targeted delivery across the blood-brain barrier.",
    "xml": "<Element 'PubmedArticle' at 0x788505c0a200>"
}