{
    "abstract": "Aetiopathogenesis of chorioangioma is already unknown. Among the risk factors, hypoxia, environmental and genetic factors are believed to induce the overexpression of angiogenic cytokines promoting vascular proliferation. We reported a\u00a0case of prenatally diagnosed 67\u2009mm-wide placental chorioangioma, which occurred at 32 weeks\u00a0of gestational age, infarcted, and followed by the onset of a second infarcted chorioangioma at 35 weeks\u00a0of gestational age. Besides, we discussed the hypothesis of chorioangioma aetiopathogenesis and behavior through a literature summary.\nWe carried out a literature search of chorioangioma cases without a time interval. Therefore, we carried out a literature summary on chorioangioma risk factors and etiology, by selecting articles within a time interval from 1995 to 2021.\nThis is the first case of two consecutive chorioangiomas in the same pregnancy published in the literature. We found a possible genetic predisposition in women developing chorioangioma while infarction may be related to the abnormal structure of tumor vessels. The onset of a second lesion could reflect hypoxic stimuli following infarction and involves hypoxia-induced factor-1alpha, vascular endothelial growth factor, transforming growth factor-beta, and soluble Fms-like tyrosine kinase-1 pathways. Chorangiosis can be coexistent and may reflect a mutual etiology in susceptible individuals.\nIn a predisposed placenta, that previously generated a chorioangioma, infarction of the chorioangioma should not represent a sign for pregnancy termination, but a marker for closer monitoring to early detect the possible onset of a second chorioangioma and a higher risk of umbilical cord thrombosis.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynaecology, Ospedale Degli Infermi, Biella University of Turin Turin Italy.\nDepartment of Obstetrics and Gynaecology 2U Sant'Anna Hospital, University of Turin Turin Italy.",
            "firstname": "Chiara",
            "initials": "C",
            "lastname": "Germano"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology Sant'Anna Hospital Turin Italy.",
            "firstname": "Eleonora",
            "initials": "E",
            "lastname": "Pilloni"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology 2U Sant'Anna Hospital, University of Turin Turin Italy.",
            "firstname": "Alessandro",
            "initials": "A",
            "lastname": "Rolfo"
        },
        {
            "affiliation": "Department of Foetal and Maternal Pathology Sant'Anna Hospital Turin Italy.",
            "firstname": "Giovanni",
            "initials": "G",
            "lastname": "Botta"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology 2U Sant'Anna Hospital, University of Turin Turin Italy.",
            "firstname": "Giulia",
            "initials": "G",
            "lastname": "Parpinel"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology Sant'Anna Hospital Turin Italy.",
            "firstname": "Paolo",
            "initials": "P",
            "lastname": "Cortese"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology Sant'Anna Hospital Turin Italy.",
            "firstname": "Ilenia",
            "initials": "I",
            "lastname": "Cotrino"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology 2U Sant'Anna Hospital, University of Turin Turin Italy.",
            "firstname": "Rossella",
            "initials": "R",
            "lastname": "Attini"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology 2U Sant'Anna Hospital, University of Turin Turin Italy.",
            "firstname": "Alberto",
            "initials": "A",
            "lastname": "Revelli"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, Ospedale Degli Infermi, Biella University of Turin Turin Italy.",
            "firstname": "Bianca",
            "initials": "B",
            "lastname": "Masturzo"
        }
    ],
    "conclusions": "In a predisposed placenta, that previously generated a chorioangioma, infarction of the chorioangioma should not represent a sign for pregnancy termination, but a marker for closer monitoring to early detect the possible onset of a second chorioangioma and a higher risk of umbilical cord thrombosis.",
    "copyrights": "\u00a9 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC.",
    "doi": "10.1002/hsr2.566",
    "journal": "Health science reports",
    "keywords": [
        "chorangiosis",
        "infarcted chorioangioma",
        "multiple chorioangiomas",
        "placental chorioangioma",
        "pregnancy",
        "pregnancy complications"
    ],
    "methods": null,
    "publication_date": "2022-04-14",
    "pubmed_id": "35415271\n21745690\n11694744\n8623784\n12747233\n27835686\n14672481\n20466884\n20595611\n20601901\n21536153\n20038496\n20838600\n17525282\n16627691\n10986432\n33120047\n29348396\n22978619\n16969001\n2220924\n26428500\n10987255\n8743160\n15944816",
    "results": "This is the first case of two consecutive chorioangiomas in the same pregnancy published in the literature. We found a possible genetic predisposition in women developing chorioangioma while infarction may be related to the abnormal structure of tumor vessels. The onset of a second lesion could reflect hypoxic stimuli following infarction and involves hypoxia-induced factor-1alpha, vascular endothelial growth factor, transforming growth factor-beta, and soluble Fms-like tyrosine kinase-1 pathways. Chorangiosis can be coexistent and may reflect a mutual etiology in susceptible individuals.",
    "title": "Consecutive chorioangiomas in the same pregnancy: A clinical case and review of literature.",
    "xml": "<Element 'PubmedArticle' at 0x7885040caed0>"
}