{
    "abstract": "Mortality prediction scores for children admitted with diarrhea are unavailable, early identification of at-risk patients for proper management remains a challenge. This study utilizes machine learning (ML) to develop a highly sensitive model for timelier identification of at-risk children admitted with acute gastroenteritis (AGE) for better management.\nWe used seven ML algorithms to build prognostic models for the prediction of mortality using de-identified data collected from children aged <5\u2009years hospitalized with AGE at Siaya County Referral Hospital (SCRH), Kenya, between 2010 through 2020. Potential predictors included demographic, medical history, and clinical examination data collected at admission to hospital. We conducted split-sampling and employed tenfold cross-validation in the model development. We evaluated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the area under the curve (AUC) for each of the models.\nDuring the study period, 12\u2009546 children aged <5\u2009years admitted at SCRH were enrolled in the inpatient disease surveillance, of whom 2271 (18.1%) had AGE and 164 (7.2%) subsequently died. The following features were identified as predictors of mortality in decreasing order: AVPU scale, Vesikari score, dehydration, sunken eyes, skin pinch, maximum number of vomits, unconsciousness, wasting, vomiting, pulse, fever, sunken fontanelle, restless, nasal flaring, diarrhea days, stridor, <90% oxygen saturation, chest indrawing, malaria, and stunting. The sensitivity ranged from 46.3%-78.0% across models, while the specificity and AUC ranged from 71.7% to 78.7% and 56.5%-82.6%, respectively. The random forest model emerged as the champion model achieving 78.0%, 76.6%, 20.6%, 97.8%, and 82.6% for sensitivity, specificity, PPV, NPV, and AUC, respectively.\nThis study demonstrates promising predictive performance of the proposed algorithm for identifying patients at risk of mortality in resource-limited settings. However, further validation in real-world clinical settings is needed to assess its feasibility and potential impact on patient outcomes.",
    "authors": [
        {
            "affiliation": "Kenya Medical Research Institute-Center for Global Health Research (KEMRI-CGHR) Kisumu Kenya.\nDepartment of Information Systems University of South Africa Pretoria South Africa.",
            "firstname": "Billy",
            "initials": "B",
            "lastname": "Ogwel"
        },
        {
            "affiliation": "Department of Information Systems University of South Africa Pretoria South Africa.",
            "firstname": "Vincent H",
            "initials": "VH",
            "lastname": "Mzazi"
        },
        {
            "affiliation": "Kenya Medical Research Institute-Center for Global Health Research (KEMRI-CGHR) Kisumu Kenya.",
            "firstname": "Bryan O",
            "initials": "BO",
            "lastname": "Nyawanda"
        },
        {
            "affiliation": "Department of Computing United States International University Nairobi Kenya.",
            "firstname": "Gabriel",
            "initials": "G",
            "lastname": "Otieno"
        },
        {
            "affiliation": "Department of Global Health University of Washington Seattle Washington USA.",
            "firstname": "Kirkby D",
            "initials": "KD",
            "lastname": "Tickell"
        },
        {
            "affiliation": "Kenya Medical Research Institute-Center for Global Health Research (KEMRI-CGHR) Kisumu Kenya.",
            "firstname": "Richard",
            "initials": "R",
            "lastname": "Omore"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Author(s). Learning Health Systems published by Wiley Periodicals LLC on behalf of University of Michigan.",
    "doi": "10.1002/lrh2.10478\n10.3389/fpubh.2020.00357",
    "journal": "Learning health systems",
    "keywords": [
        "acute gastroenteritis",
        "diarrhea",
        "machine learning",
        "mortality",
        "prediction"
    ],
    "methods": null,
    "publication_date": "2025-04-18",
    "pubmed_id": "40247897\n30243583\n31864916\n29391004\n26374802\n32356624\n30301750\n28657867\n34549197\n33575021\n34575670\n35958391\n35421085\n35285816\n38249852\n30634922\n27207342\n32188600\n27986644\n32106284\n31864346\n33747995\n20736804\n21801360\n34308121\n32719767\n35797157\n30987589\n24907244\n35898685\n29433653\n23965935\n27010047\n36660686\n30441729\n26958207",
    "results": "During the study period, 12\u2009546 children aged <5\u2009years admitted at SCRH were enrolled in the inpatient disease surveillance, of whom 2271 (18.1%) had AGE and 164 (7.2%) subsequently died. The following features were identified as predictors of mortality in decreasing order: AVPU scale, Vesikari score, dehydration, sunken eyes, skin pinch, maximum number of vomits, unconsciousness, wasting, vomiting, pulse, fever, sunken fontanelle, restless, nasal flaring, diarrhea days, stridor, <90% oxygen saturation, chest indrawing, malaria, and stunting. The sensitivity ranged from 46.3%-78.0% across models, while the specificity and AUC ranged from 71.7% to 78.7% and 56.5%-82.6%, respectively. The random forest model emerged as the champion model achieving 78.0%, 76.6%, 20.6%, 97.8%, and 82.6% for sensitivity, specificity, PPV, NPV, and AUC, respectively.",
    "title": "A machine learning approach to predicting inpatient mortality among pediatric acute gastroenteritis patients in Kenya.",
    "xml": "<Element 'PubmedArticle' at 0x788502dbb830>"
}