{
    "abstract": "To evaluate the association between gestational trophoblastic disease and the subsequent risk of developing non-trophoblastic cancer.\nWe conducted a retrospective cohort study of 3084 women with gestational trophoblastic disease and 1\u2009415\u2009812 women with obstetric deliveries in Quebec, Canada, between 1989 and 2021. The main exposure was gestational trophoblastic disease, including hydatidiform moles, invasive moles, and gestational choriocarcinoma. The outcome was development of non-trophoblastic cancer during 33\u2009years of follow-up. We measured the association of gestational trophoblastic disease with non-trophoblastic cancer using adjusted hazard ratios (HR) and 95% confidence intervals (CI), and tested whether associations were stronger for certain types of cancer or cancers with later onset.\nThe incidence of non-trophoblastic cancer was greater for women with invasive moles (47.1/10\u2009000 person-years) and gestational choriocarcinoma (59.3/10\u2009000 person-years) than hydatidiform moles (18.4/10\u2009000 person-years) and no gestational trophoblastic disease (22.4/10\u2009000 person-years). Gestational choriocarcinoma (HR 2.33, 95% CI: 1.35-4.01; P\u2009=\u20090.002) and invasive moles (HR 1.97, 95% CI: 1.06-3.65; P\u2009=\u20090.033) were associated with an elevated risk of non-trophoblastic cancer compared with no gestational trophoblastic disease, while hydatidiform moles were not. Gestational choriocarcinoma and invasive moles were mainly associated with gynecologic cancer. However, risk of cancer was limited to the short-term period after pregnancy and became similar to no gestational trophoblastic disease by the end of follow-up.\nWhile invasive moles and gestational choriocarcinoma appear to be associated with the subsequent development of non-trophoblastic cancer, the absolute risk is small and limited to the short-term.",
    "authors": [
        {
            "affiliation": "Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.\nHealth Innovation and Evaluation Hub, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.\nBureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada.",
            "firstname": "Blaise",
            "initials": "B",
            "lastname": "Munyakarama"
        },
        {
            "affiliation": "Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.\nHealth Innovation and Evaluation Hub, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.",
            "firstname": "Anita",
            "initials": "A",
            "lastname": "Koushik"
        },
        {
            "affiliation": "Department of Pathology, McGill University, Montreal, Quebec, Canada.",
            "firstname": "Val\u00e9rie",
            "initials": "V",
            "lastname": "Leduc"
        },
        {
            "affiliation": "Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.\nBureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada.",
            "firstname": "Jessica",
            "initials": "J",
            "lastname": "Healy-Profit\u00f3s"
        },
        {
            "affiliation": "Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.\nHealth Innovation and Evaluation Hub, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.\nBureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada.\nDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.",
            "firstname": "Nathalie",
            "initials": "N",
            "lastname": "Auger"
        }
    ],
    "conclusions": "While invasive moles and gestational choriocarcinoma appear to be associated with the subsequent development of non-trophoblastic cancer, the absolute risk is small and limited to the short-term.",
    "copyrights": "\u00a9 2024 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.",
    "doi": "10.1002/ijgo.15976\n10.1002/ijgo.13877\n10.1016/j.ygyno.2021.10.003\n10.1136/bmjmed-2022-000321\n10.1016/j.ejogrb.2022.03.039\n10.1055/s-0042-1742681\n10.1016/j.ygyno.2014.05.004\n10.1200/JCO.2014.57.5332\n10.1016/j.ygyno.2008.04.011\n10.1023/a:1008915217389\n10.1016/S0002-9378(99)70504-1\n10.1016/j.jogc.2020.03.001\n10.1007/BF03403824\n10.1158/1055-9965.EPI-22-0132\n10.1097/CEJ.0000000000000763\n10.1002/ijc.29475\n10.6061/clinics/2020/e1724",
    "journal": "International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics",
    "keywords": [
        "choriocarcinoma",
        "gestational trophoblastic disease",
        "gestational trophoblastic neoplasia",
        "hydatidiform mole",
        "invasive mole",
        "uterine neoplasms"
    ],
    "methods": null,
    "publication_date": "2024-10-19",
    "pubmed_id": "39425609\n34669197\n34686354\n36936581\n35367922\n35139569\n24836277\n25547507\n18514799\n10710194\n10486475\n33384141\n23618066\n35839462\n35881946\n25665163\n10762007\n32638907",
    "results": "The incidence of non-trophoblastic cancer was greater for women with invasive moles (47.1/10\u2009000 person-years) and gestational choriocarcinoma (59.3/10\u2009000 person-years) than hydatidiform moles (18.4/10\u2009000 person-years) and no gestational trophoblastic disease (22.4/10\u2009000 person-years). Gestational choriocarcinoma (HR 2.33, 95% CI: 1.35-4.01; P\u2009=\u20090.002) and invasive moles (HR 1.97, 95% CI: 1.06-3.65; P\u2009=\u20090.033) were associated with an elevated risk of non-trophoblastic cancer compared with no gestational trophoblastic disease, while hydatidiform moles were not. Gestational choriocarcinoma and invasive moles were mainly associated with gynecologic cancer. However, risk of cancer was limited to the short-term period after pregnancy and became similar to no gestational trophoblastic disease by the end of follow-up.",
    "title": "Association of gestational trophoblastic disease with subsequent development of non-trophoblastic cancer.",
    "xml": "<Element 'PubmedArticle' at 0x788503f8ee30>"
}