{
    "abstract": "The aim of our study was to explore the value of DNA (CDO1m/CELF4m) methylation detection in exfoliated cervical cells collected for screening endometrial cancer in premenopausal women with abnormal uterine bleeding.\nA total of 296 premenopausal women with abnormal uterine bleeding admitted to the Department of Obstetrics and Gynecology at the Third Xiangya Hospital of Central South University from November 2021 to October 2022 were selected. Clinical characteristics, endometrial thickness measured by transvaginal ultrasound and serum CA125 were collected. Exfoliated cervical cells from the thinPrep cytogic test were collected for DNA (CDO1m/CELF4m) methylation testing. Endometrial tissue was collected under hysteroscopy for pathological diagnosis as the gold standard. A univariate logistic regression model was used to analyze risk factors for endometrial cancer. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to measure the diagnostic efficacy of DNA methylation detection in endometrial cancer screening of women with abnormal uterine bleeding.\nUnivariate logistic regression analysis showed that age, body mass index (BMI) \u226525\u2009kg/m\nIn premenopausal women with abnormal uterine bleeding, the clinical efficacy of DNA (CDO1m/CELF4m) methylation detection in exfoliated cervical cells for endometrial cancer screening was better than that of other noninvasive clinical indicators. In addition, dual gene methylation combined with BMI or endometrial thickness was a good predictor of endometrial cancer screening.",
    "authors": [
        {
            "affiliation": "Gynecology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.\nJiangwan Research Institute, Central South University, Changsha, Hunan, China.\nPostdoctoral Station of Clinical Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.",
            "firstname": "Xingping",
            "initials": "X",
            "lastname": "Zhao"
        },
        {
            "affiliation": "Gynecology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.",
            "firstname": "Yanfei",
            "initials": "Y",
            "lastname": "Yang"
        },
        {
            "affiliation": "Gynecology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.",
            "firstname": "Yinqin",
            "initials": "Y",
            "lastname": "Fu"
        },
        {
            "affiliation": "Gynecology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China dabaoxu2022@163.com lvweigang@sklmg.edu.cn.",
            "firstname": "Weigang",
            "initials": "W",
            "lastname": "Lv"
        },
        {
            "affiliation": "Gynecology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China dabaoxu2022@163.com lvweigang@sklmg.edu.cn.",
            "firstname": "Dabao",
            "initials": "D",
            "lastname": "Xu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.",
    "doi": "10.1136/ijgc-2024-005723",
    "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
    "keywords": [
        "Endometrial Neoplasms"
    ],
    "methods": null,
    "publication_date": "2024-07-24",
    "pubmed_id": "39043572",
    "results": "Univariate logistic regression analysis showed that age, body mass index (BMI) \u226525\u2009kg/m",
    "title": "DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding.",
    "xml": "<Element 'PubmedArticle' at 0x788505511350>"
}