{
    "abstract": "Geniposide (GP) provides myocardial cells with protection against pyroptosis-induced damage. However, the mechanisms governing GP's effect on the thioredoxin-interacting protein (TXNIP)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) signaling pathway remain unclear. This study aimed to explore how GP alleviates post-myocardial infarction (MI)-induced pyroptosis through regulation of the TXNIP/NLRP3 pathway.\nGP greatly diminishes the extent of infarcted myocardial tissue and mitigates pyroptosis, which improves cardiac structure and function through modulation of the TXNIP/NLRP3 pathway. Furthermore, the inhibition of NLRP3 lowers the expressions of factors associated with pyroptosis in the cardiac tissue and reduces ROS production.",
    "authors": [
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Youqin",
            "initials": "Y",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Yao",
            "initials": "Y",
            "lastname": "Su"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Chen",
            "initials": "C",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Weiwei",
            "initials": "W",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Yang",
            "initials": "Y",
            "lastname": "Wei"
        },
        {
            "affiliation": "Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Guanglei",
            "initials": "G",
            "lastname": "Chang"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Ya",
            "initials": "Y",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, The People's Hospital of Yubei District of Chongqing, Chongqing, China.",
            "firstname": "Honghong",
            "initials": "H",
            "lastname": "He"
        }
    ],
    "conclusions": "GP greatly diminishes the extent of infarcted myocardial tissue and mitigates pyroptosis, which improves cardiac structure and function through modulation of the TXNIP/NLRP3 pathway. Furthermore, the inhibition of NLRP3 lowers the expressions of factors associated with pyroptosis in the cardiac tissue and reduces ROS production.",
    "copyrights": "\u00a9 2024 The Author(s). Published by Scientific Scholar.",
    "doi": "10.25259/Cytojournal_139_2024\n10.1038/s41420-018-0036-7\n10.1038/s41420-021-00563-4\n10.1073/pnas.1108586108\n10.1155/2017/9743280\n10.1016/j.cca.2020.06.044\n10.1186/s12967-022-03229-6\n10.1038/nature15514\n10.1038/s41418-021-00867-z\n10.3389/fphys.2022.907504\n10.1177/1074248416675731\n10.1038/nature09663\n10.1016/j.phrs.2015.05.012\n10.3389/fimmu.2013.00514\n10.3389/fimmu.2023.1155222\n10.2147/DDDT.S292107\n10.1039/C8RA01038B\n10.1155/2019/7480512\n10.1139/cjpp-2014-0536\n10.1016/j.jep.2005.08.011\n10.1159/000445634\n10.3109/13880209.2012.717088\n10.1371/journal.pone.0081349\n10.3923/pjbs.2009.949.956\n10.1016/j.intimp.2020.106609\n10.1385/1-59745-214-9:271\n10.1111/bph.13449\n10.3390/molecules22101689\n10.1161/01.CIR.99.21.2750\n10.1016/0735-1097(89)90360-4\n10.1155/2020/6976153\n10.1111/jcmm.15045\n10.3390/vaccines11050993\n10.1016/j.transproceed.2017.02.063\n10.1093/cvr/cvn335\n10.1172/JCI44927\n10.1007/s40618-016-0591-9\n10.1016/j.intimp.2020.106547",
    "journal": "CytoJournal",
    "keywords": [
        "Geniposide",
        "Myocardial infarction",
        "NLRP3 protein",
        "Pyroptosis",
        "Thioredoxin-interacting protein"
    ],
    "methods": null,
    "publication_date": "2025-02-07",
    "pubmed_id": "39916997\n29531832\n34230460\n22106299\n29062465\n32622968\n35033112\n26375003\n34511601\n35755447\n27807222\n21124315\n26054569\n24409188\n37063905\n33688169\n35539637\n31089416\n25730420\n16169698\n27372651\n23116215\n24349058\n19817121\n32446199\n17172694\n26845648\n28994736\n10351968\n2656824\n33224989\n32039564\n37243097\n28736023\n19047340\n22201682\n28000177\n32361652",
    "results": "",
    "title": "Geniposide alleviates post-myocardial infarction-induced pyroptosis by modulating the thioredoxin-interacting protein/NLRP3 signaling pathway.",
    "xml": "<Element 'PubmedArticle' at 0x788506f6e7f0>"
}