{
    "abstract": "BackgroundFocusing on calcitonin gene-related peptide (CGRP) as a specific target has changed and improved migraine management. After the positive results of monoclonal antibodies directed to the CGRP pathway (anti-CGRP mAbs), randomized controlled trials also demonstrated the efficacy of gepants in migraine prevention. The present study aimed to assess the effectiveness of atogepant in preventing migraine after a 12-week treatment in clinical practice.MethodsAdult patients with a clinical indication for atogepant 60 mg daily were screened for participation in this multicentric prospective observational cohort study. At baseline (T0) and after 12 weeks (T3) since the first atogepant administration, monthly migraine days (MMDs), monthly headache days (MHDs) and monthly acute medications (MAMs) were assessed. The co-primary endpoints were the changes in MMDs from T0 to T3 and the percentage of T3 Responders (those with a reduction of MMDs \u226550%, i.e. 50% response rate (RR)). At T0 and T3, we also collected the Headache Impact Test (HIT-6), the Migraine Disability Assessment (MIDAS) questionnaire, the Migraine Treatment Optimization Questionnaire-6 (mTOQ-6), the Migraine-Specific Quality-of-Life Questionnaire (MSQ), the 12-item Allodynia Symptom Checklist (ASC-12) and the Migraine Interictal Burden Scale (MIBS-4).ResultsOne hundred and six patients (56/106 (52.8%) with chronic migraine (CM), 93/106 (87.7%) female, aged 50.6\u2009\u00b1\u200913.2 years) from 10 Italian centers completed the 12-week observation since the first atogepant tablet intake. From baseline to T3, a reduction of 6.9 MMDs (SD 9.7; ",
    "authors": [
        {
            "affiliation": "Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.\nNeurology Unit, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy.",
            "firstname": "Fabrizio",
            "initials": "F",
            "lastname": "Vernieri"
        },
        {
            "affiliation": "Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico Di Modena, Modena, Italy.\nDepartment of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Luigi Francesco",
            "initials": "LF",
            "lastname": "Iannone"
        },
        {
            "affiliation": "Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico Di Modena, Modena, Italy.",
            "firstname": "Flavia",
            "initials": "F",
            "lastname": "Lo Castro"
        },
        {
            "affiliation": "Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.",
            "firstname": "Gabriele",
            "initials": "G",
            "lastname": "Sebastianelli"
        },
        {
            "affiliation": "Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.",
            "firstname": "Federico",
            "initials": "F",
            "lastname": "De Santis"
        },
        {
            "affiliation": "Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.\nHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.",
            "firstname": "Michele",
            "initials": "M",
            "lastname": "Corrado"
        },
        {
            "affiliation": "Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.\nNeurology Unit, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy.",
            "firstname": "Marilena",
            "initials": "M",
            "lastname": "Marcosano"
        },
        {
            "affiliation": "Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.",
            "firstname": "Raffaele",
            "initials": "R",
            "lastname": "Ornello"
        },
        {
            "affiliation": "Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.",
            "firstname": "Licia",
            "initials": "L",
            "lastname": "Grazzi"
        },
        {
            "affiliation": "Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.",
            "firstname": "Danilo Antonio",
            "initials": "DA",
            "lastname": "Montisano"
        },
        {
            "affiliation": "Headache center and Clinical Pharmacology, AOU Careggi, Florence, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "De Cesaris"
        },
        {
            "affiliation": "Headache center and Clinical Pharmacology, AOU Careggi, Florence, Italy.",
            "firstname": "Antonio",
            "initials": "A",
            "lastname": "Munaf\u00f2"
        },
        {
            "affiliation": "Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.\nHeadache Unit, Ospedale S. Pietro Fatebenefratelli, Roma, Italy.",
            "firstname": "Luisa",
            "initials": "L",
            "lastname": "Fofi"
        },
        {
            "affiliation": "Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy.",
            "firstname": "Alberto",
            "initials": "A",
            "lastname": "Doretti"
        },
        {
            "affiliation": "Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.\nHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.",
            "firstname": "Gloria",
            "initials": "G",
            "lastname": "Vaghi"
        },
        {
            "affiliation": "Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.",
            "firstname": "Francesca",
            "initials": "F",
            "lastname": "Pistoia"
        },
        {
            "affiliation": "Neurology Department, Azienda Ospedaliero Universitaria, Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.",
            "firstname": "Delfina",
            "initials": "D",
            "lastname": "Ferrandi"
        },
        {
            "affiliation": "Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.",
            "firstname": "Stefania",
            "initials": "S",
            "lastname": "Battistini"
        },
        {
            "affiliation": "Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.",
            "firstname": "Simona",
            "initials": "S",
            "lastname": "Sacco"
        },
        {
            "affiliation": "Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico Di Modena, Modena, Italy.\nDepartment of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.",
            "firstname": "Simona",
            "initials": "S",
            "lastname": "Guerzoni"
        },
        {
            "affiliation": "Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.\nNeurology Unit, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy.",
            "firstname": "Claudia",
            "initials": "C",
            "lastname": "Altamura"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1177/03331024251335927",
    "journal": "Cephalalgia : an international journal of headache",
    "keywords": [
        "atogepant",
        "migraine prevention",
        "real-world studies"
    ],
    "methods": null,
    "publication_date": "2025-04-23",
    "pubmed_id": "40267275",
    "results": null,
    "title": "Effectiveness and tolerability of atogepant in the prevention of migraine: A real life, prospective, multicentric study (the STAR study).",
    "xml": "<Element 'PubmedArticle' at 0x788505a11b20>"
}