{
    "abstract": "Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by thromboembolic and obstetric complications in the presence of persistent antiphospholipid antibodies (aPL). Treatment aims to prevent recurrent thrombosis, primarily using anticoagulation therapy with vitamin K antagonists (VKA). Monitoring of VKA therapy relies on the International Normalized Ratio (INR), which can be assessed using point-of-care testing (POCT). However, in a subset of APS patients with a high-risk aPL profile, the POCT-INR is falsely elevated, which might lead to underdosing of VKA and subsequent high risk of recurrent thrombosis. This case report describes two female patients with triple-positive thrombotic APS receiving VKA therapy. Both patients underwent biweekly paired INR measurements via POCT-INR and venous INR methods. Despite significant discrepancies, a strong individual linear correlation was observed: ",
    "authors": [
        {
            "affiliation": "Division Internal Medicine and Dermatology, Department of Clinical Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, The Netherlands.",
            "firstname": "Bettina C",
            "initials": "BC",
            "lastname": "Geertsema-Hoeve"
        },
        {
            "affiliation": "Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.",
            "firstname": "Massimo",
            "initials": "M",
            "lastname": "Radin"
        },
        {
            "affiliation": "Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.",
            "firstname": "Savino",
            "initials": "S",
            "lastname": "Sciascia"
        },
        {
            "affiliation": "Division Laboratories, Pharmacy and Medical Sciences, Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.",
            "firstname": "Rolf T",
            "initials": "RT",
            "lastname": "Urbanus"
        },
        {
            "affiliation": "Division Laboratories, Pharmacy and Medical Sciences, Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.",
            "firstname": "Albert",
            "initials": "A",
            "lastname": "Huisman"
        },
        {
            "affiliation": "Division Internal Medicine and Dermatology, Department of Clinical Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, The Netherlands.",
            "firstname": "Josine",
            "initials": "J",
            "lastname": "Borgsteede-de Wilde"
        },
        {
            "affiliation": "Division Internal Medicine and Dermatology, Department of Clinical Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, The Netherlands.",
            "firstname": "Maarten",
            "initials": "M",
            "lastname": "Limper"
        }
    ],
    "conclusions": null,
    "copyrights": "The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).",
    "doi": "10.1055/a-2542-5358",
    "journal": "TH open : companion journal to thrombosis and haemostasis",
    "keywords": [
        "International Normalized Ratio",
        "antiphospholipid syndrome",
        "case report",
        "point-of-care testing",
        "vitamin-k antagonists"
    ],
    "methods": null,
    "publication_date": "2025-03-21",
    "pubmed_id": "40115662\n37635643\n36849186\n31012427\n15638860\n36891523\n25859986\n37001919\n11736953\n18568340\n12059082\n29648992\n19191068\n10586206\n33421291",
    "results": null,
    "title": "Problem Solved? An Individual Ratio between Point-of-Care and Venous International Normalized Ratio Values in Two Patients with Antiphospholipid Syndrome: Two Case Reports.",
    "xml": "<Element 'PubmedArticle' at 0x788505ff8950>"
}