{
    "abstract": "Patients who receive frequent blood transfusions are at an elevated risk of developing hepatic fibrosis due to iron overload in the liver. In this study, we evaluated the effectiveness of transient elastography (TE) (FibroScan\nWe enrolled 106 consecutive cases of acute leukemia in individuals under 21 years of age. The participants were followed for 2 years. Based on their serum ferritin (SF) levels, the patients were divided into two groups: group 1 (SF\u2265300 ng/mL) and group 2 (SF<300 ng/mL). A liver FibroScan\nAmong the various parameters in the liver function test (LFT), alkaline phosphatase was significantly higher in a subgroup of patients aged 5-8 years in group 2 compared to those in group 1. The indices of liver fibrosis determined by TE, including the FibroScan score, controlled attenuation parameter score, steatosis percentage, and meta-analysis of histological data in viral hepatitis score, as well as indirect serum markers of liver fibrosis such as the aminotransferase (AST)/alanine aminotransferase (ALT) ratio, Fibrosis 4 score, and AST to platelet ratio index, did not differ significantly between the two groups. The association between the TE results and LFT parameters was only significant for ALT.\nTransfusion-associated iron overload does not have a significant correlation with severe liver fibrosis. FibroScan",
    "authors": [
        {
            "affiliation": "Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.",
            "firstname": "Mahsa",
            "initials": "M",
            "lastname": "Sobhani"
        },
        {
            "affiliation": "Gastroenterology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.",
            "firstname": "Naser",
            "initials": "N",
            "lastname": "Honar"
        },
        {
            "affiliation": "Gastroenterology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.",
            "firstname": "Mohammadreza",
            "initials": "M",
            "lastname": "Fattahi"
        },
        {
            "affiliation": "Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.",
            "firstname": "Sezaneh",
            "initials": "S",
            "lastname": "Haghpanah"
        },
        {
            "affiliation": "Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.",
            "firstname": "Nader",
            "initials": "N",
            "lastname": "Shakibazad"
        },
        {
            "affiliation": "Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.",
            "firstname": "Mohammadreza",
            "initials": "M",
            "lastname": "Bordbar"
        }
    ],
    "conclusions": "Transfusion-associated iron overload does not have a significant correlation with severe liver fibrosis. FibroScan",
    "copyrights": "Copyright \u00a9 2024 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.",
    "doi": "10.5223/pghn.2024.27.4.215",
    "journal": "Pediatric gastroenterology, hepatology & nutrition",
    "keywords": [
        "Blood transfusion",
        "Iron overload",
        "Leukemia",
        "Liver cirrhosis",
        "Liver function tests"
    ],
    "methods": null,
    "publication_date": "2024-07-22",
    "pubmed_id": "39035402\n24804175\n26713769\n19663936\n18581200\n22427472\n19140221\n23049764\n17879910\n16394849\n16628644\n22261353\n18496894\n18705692\n20101745\n24939348\n16696812\n22229701\n17498249\n20105330\n18081722\n22727143\n24158528\n27984631\n28405327\n20658587\n28532285\n15860670",
    "results": "Among the various parameters in the liver function test (LFT), alkaline phosphatase was significantly higher in a subgroup of patients aged 5-8 years in group 2 compared to those in group 1. The indices of liver fibrosis determined by TE, including the FibroScan score, controlled attenuation parameter score, steatosis percentage, and meta-analysis of histological data in viral hepatitis score, as well as indirect serum markers of liver fibrosis such as the aminotransferase (AST)/alanine aminotransferase (ALT) ratio, Fibrosis 4 score, and AST to platelet ratio index, did not differ significantly between the two groups. The association between the TE results and LFT parameters was only significant for ALT.",
    "title": "Association between Transfusion-Related Iron Overload and Liver Fibrosis in Survivors of Pediatric Leukemia: A Cross-Sectional Study.",
    "xml": "<Element 'PubmedArticle' at 0x7885054f31f0>"
}