{
    "abstract": "Automated hematology analyzers are routinely used to assess blood cell counts and leukocyte differentials. However, the accuracy of assessing neutrophil percentages with automated hematology analyzers in patients undergoing chemotherapy has not been examined. In this study, the correlation between neutrophil percentages calculated by automated hematology analyzers and those obtained through manual microscopic examinations by laboratory technicians was investigated on the day of chemotherapy initiation in 125 patients receiving CHOP-based chemotherapy for malignant lymphoma. Peripheral blood counts and 5-part leukocyte differential percentages were analyzed using the Sysmex XE-5000 system. An examination of 797 samples from each chemotherapy course showed a favorable correlation between the two methods (Pearson's r\u2009=\u20090.917). However, this correlation significantly diminished in samples when the bone marrow nucleated cell count was\u2009\u2264\u200950\u2009\u00d7\u200910",
    "authors": [
        {
            "affiliation": "Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan. h-hosoi@wakayama-med.ac.jp.\nDepartment of Transfusion Medicine, Wakayama Medical University Hospital, Wakayama, Japan. h-hosoi@wakayama-med.ac.jp.",
            "firstname": "Hiroki",
            "initials": "H",
            "lastname": "Hosoi"
        },
        {
            "affiliation": "Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.",
            "firstname": "Tadashi",
            "initials": "T",
            "lastname": "Okamura"
        },
        {
            "affiliation": "Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.",
            "firstname": "Shotaro",
            "initials": "S",
            "lastname": "Tabata"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Wakayama Medical University Hospital, Wakayama, Japan.",
            "firstname": "Naoto",
            "initials": "N",
            "lastname": "Minoura"
        },
        {
            "affiliation": "Clinical Study Support Center, Wakayama Medical University, Wakayama, Japan.",
            "firstname": "Ke",
            "initials": "K",
            "lastname": "Wan"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Wakayama Medical University Hospital, Wakayama, Japan.",
            "firstname": "Kazuhiro",
            "initials": "K",
            "lastname": "Hirayasu"
        },
        {
            "affiliation": "Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.",
            "firstname": "Shogo",
            "initials": "S",
            "lastname": "Murata"
        },
        {
            "affiliation": "Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.",
            "firstname": "Toshiki",
            "initials": "T",
            "lastname": "Mushino"
        },
        {
            "affiliation": "Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.\nDepartment of Transfusion Medicine, Wakayama Medical University Hospital, Wakayama, Japan.",
            "firstname": "Takashi",
            "initials": "T",
            "lastname": "Sonoki"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1007/s00277-025-06313-1\n10.1111/ijlh.13486\n10.1046/j.1365-2257.1998.00121.x\n10.1016/j.leukres.2011.06.015\n10.1002/cncr.11882\n10.1056/NEJM199304083281404\n10.1093/ajcp/92.3.280\n10.1002/1097-0320(20001215)42:6<371::AID-CYTO1004>3.0.CO;2-G\n10.1093/labmed/lmaa058\n10.1309/AJCPDUZVRN5VY9WZ\n10.1309/AJCP4V4EXYFFOELL\n10.1111/ijlh.12327\n10.1002/cyto.990060502\n10.1093/ajcp/108.6.674\n10.1111/ijlh.12254\n10.1111/ijlh.13069\n10.1016/S0140-6736(13)60313-X\n10.1002/cam4.200\n10.1056/NEJMoa1408617\n10.1111/ijlh.13042",
    "journal": "Annals of hematology",
    "keywords": [
        "Automated hematology analyzer",
        "Differential leukocyte count",
        "Malignant lymphoma",
        "Neutrophil",
        "Outpatient chemotherapy"
    ],
    "methods": null,
    "publication_date": "2025-03-20",
    "pubmed_id": "40111499\n33586915\n9681228\n21764450\n14716755\n7680764\n2476027\n11135291\n32816034\n23596115\n25239424\n25728865\n4042782\n9384450\n24815300\n31162809\n23615461\n24706592\n25426837\n32736382\n31046197",
    "results": null,
    "title": "Favorable correlation between neutrophil percentages obtained using automated hematology analyzers and microscopic examinations in malignant lymphoma patients receiving chemotherapy.",
    "xml": "<Element 'PubmedArticle' at 0x78850495e7a0>"
}