{
    "abstract": "Named after the Greek term for \"hard fat\", stearic acid has gradually entered people's field of vision. As an important component of various physiological cellular functions, stearic acid plays a regulatory role in diverse aspects of energy metabolism and signal transduction. Its applications range from serving as a bodily energy source to participating in endogenous biosynthesis. Similar to palmitate, stearic acid serves as a primary substrate for the stearoyl coenzyme A desaturase, which catalyzes the conversion of stearate to oleate and is involved in the synthesis of triglyceride and other complex lipids. Additionally, stearic acid functions as a vital signaling molecule in pathological processes such as cardiovascular diseases, diabetes development, liver injury and even nervous system disorders. Therefore, we conduct a comprehensive review of stearic acid, summarizing its role in various diseases and attempting to provide a systematic overview of its homeostasis, physiological functions, and pathological process. From a medical standpoint, we also explore potential applications and discuss stearic acid as a potential therapeutic target for the treatment of human diseases.",
    "authors": [
        {
            "affiliation": "Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China; School of Basic Medicine, Qingdao University, Qingdao, China.",
            "firstname": "Xinyi",
            "initials": "X",
            "lastname": "Shen"
        },
        {
            "affiliation": "School of Basic Medicine, Qingdao University, Qingdao, China.",
            "firstname": "Shuo",
            "initials": "S",
            "lastname": "Miao"
        },
        {
            "affiliation": "Department of Operating Room, Affiliated Hospital of Qingdao University, Qingdao, China.",
            "firstname": "Yaping",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Operating Room, Affiliated Hospital of Qingdao University, Qingdao, China.",
            "firstname": "Xingying",
            "initials": "X",
            "lastname": "Guo"
        },
        {
            "affiliation": "Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China.",
            "firstname": "Wenxian",
            "initials": "W",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: XMsubmit@163.com.",
            "firstname": "Xin",
            "initials": "X",
            "lastname": "Mao"
        },
        {
            "affiliation": "Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: Qingsong3333@163.com.",
            "firstname": "Qingsong",
            "initials": "Q",
            "lastname": "Zhang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.",
    "doi": "10.1016/j.clnu.2024.12.012",
    "journal": "Clinical nutrition (Edinburgh, Scotland)",
    "keywords": [
        "Cancer",
        "Cardiovascular diseases",
        "Metabolic syndrome",
        "Neurodegenerative diseases",
        "Stearic acid"
    ],
    "methods": null,
    "publication_date": "2024-12-22",
    "pubmed_id": "39709650",
    "results": null,
    "title": "Stearic acid metabolism in human health and disease.",
    "xml": "<Element 'PubmedArticle' at 0x788503ce1ee0>"
}