{
    "abstract": "Progressive hemifacial atrophy (PHA) is a rare condition marked by the gradual degeneration of skin, soft tissues, muscles, and, in advanced stages, bone. The primary approach for managing PHA involves surgical interventions to reconstruct and restore the facial contour. The current treatments each present several limitations. Therefore, there is a critical need for innovative therapeutic methodologies for PHA soft-tissue reconstruction.\nEight patients diagnosed with Guerrerosantos II and III PHA were included in the study. Preoperative 3-dimensional facial scans were digitally analyzed, and corresponding 3-dimensional-printed models were generated to assess soft-tissue deficiencies. Based on this evaluation, acellular dermal matrix (ADM) was tailored to a stepped, multilayered composite dermis of a specific shape and size. It was then anatomically anchored at precise locations and supplemented with volume filler and ligament-mimicking repairs.\nThe location, volume, and thickness of the ADM postoperatively were highly compatible with preoperative evaluations, significantly improving the facial contour and morphological and volumetric differences. All patients achieved good healing without other complications and reported improved postoperative scores on the FACE-Q craniofacial modules (\nStructural repair of PHA using ADM, guided by preoperative digital assessments, provides a safe, effective, and relatively stable outcome. This approach is innovative for achieving precise facial reconstruction.",
    "authors": [
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.\nZhengzhou Key Laboratory of Tissue Engineering and Plastic Reconstruction, Zhengzhou, Henan, China.",
            "firstname": "Xinhao",
            "initials": "X",
            "lastname": "Cheng"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.\nZhengzhou Key Laboratory of Tissue Engineering and Plastic Reconstruction, Zhengzhou, Henan, China.",
            "firstname": "Haijiang",
            "initials": "H",
            "lastname": "Dong"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.",
            "firstname": "Chengxiang",
            "initials": "C",
            "lastname": "Yan"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.\nZhengzhou Key Laboratory of Tissue Engineering and Plastic Reconstruction, Zhengzhou, Henan, China.",
            "firstname": "Zhibin",
            "initials": "Z",
            "lastname": "Li"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.",
            "firstname": "Baihui",
            "initials": "B",
            "lastname": "Xie"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.\nZhengzhou Key Laboratory of Tissue Engineering and Plastic Reconstruction, Zhengzhou, Henan, China.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Li"
        },
        {
            "affiliation": "Medical 3D Printing Key Laboratory of Henan Province, Medical 3D Printing Center of Henan Province, Zhengzhou, Henan, China.",
            "firstname": "Huilong",
            "initials": "H",
            "lastname": "Liu"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.",
            "firstname": "Yijun",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "From the Medical Cosmetic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.\nZhengzhou Key Laboratory of Tissue Engineering and Plastic Reconstruction, Zhengzhou, Henan, China.",
            "firstname": "Ximei",
            "initials": "X",
            "lastname": "Wang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.",
    "doi": "10.1097/GOX.0000000000006558",
    "journal": "Plastic and reconstructive surgery. Global open",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-02-24",
    "pubmed_id": "39989891\n30851754\n27045226\n23827688\n25881068\n16443052\n33615047\n34662020\n36624141\n27045226\n37406920\n35077421\n34181618\n26355969\n37092964\n30817656\n30688900\n38036368\n31985645\n31886486\n34519702\n25953499\n32277744\n27898976\n26492185\n7082067\n37289941\n26340759\n19319054\n16141804\n22075830\n19288409\n34501311\n37166041\n31637412\n29781904\n36988657",
    "results": "The location, volume, and thickness of the ADM postoperatively were highly compatible with preoperative evaluations, significantly improving the facial contour and morphological and volumetric differences. All patients achieved good healing without other complications and reported improved postoperative scores on the FACE-Q craniofacial modules (",
    "title": "Treatment of Mild-to-moderate Progressive Hemifacial Atrophy by Acellular Dermal Matrix Combined With Preoperative Digital Evaluation.",
    "xml": "<Element 'PubmedArticle' at 0x788505f24180>"
}