{
    "abstract": "New potential biomarkers to pre-intervention identification of a clinically significant prostate cancer (csPCa) will prevent overdiagnosis and overtreatment and limit quality of life impairment of PCa patients.\nWe have developed a comprehensive review focusing our research on the increasing knowledge of the role of SelectMDX\u00ae in csPCa detection. Areas identified as clinically relevant are the ability of SelectMDX\u00ae to predict csPCa in active surveillance setting, its predictive ability when combined with multiparametric MRI and the role of SelectMDX\u00ae in the landscape of urinary biomarkers.\nSeveral PCa biomarkers have been developed either alone or in combination with clinical variables to improve csPCa detection. SelectMDX\u00ae score includes genomic markers, age, PSA, prostate volume, and digital rectal examination. Several studies have shown consistency in the ability to improve detection of csPCa, avoidance of unnecessary prostate biopsies, helpful in decision-making for clinical benefit of PCa patients with future well designed, and impactful studies.",
    "authors": [
        {
            "affiliation": "Department of Urology, IEO - European Institute of Oncology, IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico, via Ripamonti 435, Milan 20141, Italy.",
            "firstname": "Matteo",
            "initials": "M",
            "lastname": "Ferro"
        },
        {
            "affiliation": "Unit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo and Carlo, Via A. Di Rudini 8, Milan 20142, Italy.",
            "firstname": "Bernardo",
            "initials": "B",
            "lastname": "Rocco"
        },
        {
            "affiliation": "Department of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.",
            "firstname": "Martina",
            "initials": "M",
            "lastname": "Maggi"
        },
        {
            "affiliation": "Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Umberto I - 70121, Bari, Italy.",
            "firstname": "Giuseppe",
            "initials": "G",
            "lastname": "Lucarelli"
        },
        {
            "affiliation": "Department of Urology and Organ Transplantation, University of Foggia, Via A.Gramsci 89/91, 71122 Foggia, Italy.",
            "firstname": "Ugo Giovanni",
            "initials": "UG",
            "lastname": "Falagario"
        },
        {
            "affiliation": "Department of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "Del Giudice"
        },
        {
            "affiliation": "Department of Neurosciences and Reproductive Sciences and Odontostomatology, University of Naples Federico II, Via Pansini, 5 - 80131, Naples, Italy.",
            "firstname": "Felice",
            "initials": "F",
            "lastname": "Crocetto"
        },
        {
            "affiliation": "Department of Surgical Sciences, Urology Unit, AORN Sant'Anna e San Sebastiano, Caserta, Via Ferdinando Palasciano, 81100 Caserta , Italy.",
            "firstname": "Biagio",
            "initials": "B",
            "lastname": "Barone"
        },
        {
            "affiliation": "Department of Translational Medical Sciences, University of Naples \"Federico II\", Corso Umberto I 40 - 80138 Naples, Italy.",
            "firstname": "Evelina",
            "initials": "E",
            "lastname": "La Civita"
        },
        {
            "affiliation": "Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Umberto I - 70121, Bari, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "Lasorsa"
        },
        {
            "affiliation": "Department of Urology, IEO - European Institute of Oncology, IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico, via Ripamonti 435, Milan 20141, Italy.",
            "firstname": "Antonio",
            "initials": "A",
            "lastname": "Brescia"
        },
        {
            "affiliation": "Department of Urology, IEO - European Institute of Oncology, IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico, via Ripamonti 435, Milan 20141, Italy.",
            "firstname": "Michele",
            "initials": "M",
            "lastname": "Catellani"
        },
        {
            "affiliation": "Department of Urology and Organ Transplantation, University of Foggia, Via A.Gramsci 89/91, 71122 Foggia, Italy.",
            "firstname": "Gian Maria",
            "initials": "GM",
            "lastname": "Busetto"
        },
        {
            "affiliation": "Department of Simulation Applied in Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mures, Gh Marinescu 35, 540142 T\u00e2rgu Mures, Romania.",
            "firstname": "Octavian Sabin",
            "initials": "OS",
            "lastname": "Tataru"
        },
        {
            "affiliation": "Department of Translational Medical Sciences, University of Naples \"Federico II\", Corso Umberto I 40 - 80138 Naples, Italy.",
            "firstname": "Daniela",
            "initials": "D",
            "lastname": "Terracciano"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1080/14737159.2023.2277366",
    "journal": "Expert review of molecular diagnostics",
    "keywords": [
        "Select MDX\u00ae",
        "biomarker",
        "clinically significant prostate cancer",
        "diagnosis",
        "magnetic resonance imaging"
    ],
    "methods": null,
    "publication_date": "2023-10-29",
    "pubmed_id": "37897252",
    "results": null,
    "title": "Beyond blood biomarkers: the role of SelectMDX in clinically significant prostate cancer identification.",
    "xml": "<Element 'PubmedArticle' at 0x788502de1c10>"
}