{
    "abstract": "Liver venous deprivation (LVD) is known to induce better future liver remnant (FLR) hypertrophy than portal vein embolization (PVE). The role of LVD, compared with PVE, in inducing FLR hypertrophy and allowing safe hepatectomy for patients with extensive colorectal liver metastases (CLM) and high-risk factors for inadequate hypertrophy remains unclear.\nPatients undergoing LVD (n\u00a0=\u00a022) were matched to patients undergoing PVE (n\u00a0=\u00a0279) in a 1:3 ratio based on propensity scores, prior to planned hepatectomy for CLM at a single center (1998-2023). The propensity scores accounted for high-risk factors for inadequate hypertrophy, namely pre-procedure standardized FLR (sFLR), body mass index, number of systemic therapy cycles, an extension of PVE to segment IV portal vein branches, prior resection, and chemotherapy-associated liver injury.\nThe matched cohort included 78 patients (LVD, n\u00a0=\u00a022; PVE, n\u00a0=\u00a056). Baseline characteristics were comparable. The number of tumors in the whole liver was similar but more LVD patients had five or more tumors in the left liver (32% vs. 11%; p\u00a0=\u00a00.024). Post-procedure sFLR was similar but LVD patients had a significantly higher degree of hypertrophy (16% vs. 11%; p\u00a0=\u00a00.017) and kinetic growth rate (3.9 vs. 2.4% per week; p\u00a0=\u00a00.006). More LVD patients underwent extended right hepatectomy (93% vs. 55%; p\u00a0=\u00a00.008). Only one patient had postoperative hepatic insufficiency after PVE, and no patients died within 90 days of hepatectomy.\nIn patients with extensive CLM and high-risk factors, LVD is associated with better FLR hypertrophy compared with PVE and allows for safely performing curative-intent extended major hepatectomy.",
    "authors": [
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Antony",
            "initials": "A",
            "lastname": "Haddad"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Mohammad Mahdi",
            "initials": "MM",
            "lastname": "Khavandi"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Mateo",
            "initials": "M",
            "lastname": "Lendoire"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Belkacem",
            "initials": "B",
            "lastname": "Acidi"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Yi-Ju",
            "initials": "YJ",
            "lastname": "Chiang"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Sanjay",
            "initials": "S",
            "lastname": "Gupta"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Alda",
            "initials": "A",
            "lastname": "Tam"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Bruno C",
            "initials": "BC",
            "lastname": "Odisio"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Armeen",
            "initials": "A",
            "lastname": "Mahvash"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Mohamed E",
            "initials": "ME",
            "lastname": "Abdelsalam"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Ethan",
            "initials": "E",
            "lastname": "Lin"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Joshua",
            "initials": "J",
            "lastname": "Kuban"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Timothy E",
            "initials": "TE",
            "lastname": "Newhook"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Hop S",
            "initials": "HS",
            "lastname": "Tran Cao"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Ching-Wei D",
            "initials": "CD",
            "lastname": "Tzeng"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
            "firstname": "Steven Y",
            "initials": "SY",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jvauthey@mdanderson.org.",
            "firstname": "Jean-Nicolas",
            "initials": "JN",
            "lastname": "Vauthey"
        },
        {
            "affiliation": "Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. PHabibollahi@mdanderson.org.",
            "firstname": "Peiman",
            "initials": "P",
            "lastname": "Habibollahi"
        }
    ],
    "conclusions": "In patients with extensive CLM and high-risk factors, LVD is associated with better FLR hypertrophy compared with PVE and allows for safely performing curative-intent extended major hepatectomy.",
    "copyrights": "\u00a9 2024. Society of Surgical Oncology.",
    "doi": "10.1245/s10434-024-16558-1\n10.1067/msy.2000.105294\n10.1001/archsurg.137.6.675\n10.1007/BF01655244\n10.1002/bjs.5836\n10.1016/j.jamcollsurg.2012.10.018\n10.1245/s10434-012-2864-7\n10.1007/s11605-017-3467-1\n10.1016/j.jamcollsurg.2006.12.032\n10.1002/bjs.9317\n10.1097/SLA.0b013e3181b674df\n10.1097/SLA.0b013e31819ecc5c\n10.1007/s00330-020-06746-4\n10.1007/s00330-016-4291-9\n10.1007/s00330-017-4744-9\n10.21037/hbsn.2020.02.06\n10.1016/j.surg.2019.12.006\n10.1007/s11605-022-05551-2\n10.21037/hbsn.2019.07.06\n10.1093/bjs/znaa149\n10.1016/j.hpb.2024.07.409\n10.1016/j.gassur.2024.02.020\n10.1007/s11605-016-3145-8\n10.1245/s10434-010-1166-1\n10.1200/JCO.2005.05.3074\n10.1053/jlts.2002.31654\n10.1002/ags3.12689\n10.1016/S1470-2045(24)00039-1\n10.1016/j.jvir.2022.10.011\n10.1016/S1365-182X(17)30755-4\n10.1097/SLA.0000000000003905\n10.1007/s00270-022-03107-0\n10.1007/s00270-018-2075-0\n10.1007/s11605-013-2369-0\n10.1200/JCO.2010.32.6132\n10.1016/j.jamcollsurg.2015.12.057\n10.1186/s12885-020-07065-z\n10.1093/bjs/znae087",
    "journal": "Annals of surgical oncology",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-12-05",
    "pubmed_id": "39633174\n2333592\n10819059\n12049538\n3022488\n17583900\n23219349\n23377564\n28585106\n17481498\n24227364\n19730239\n19300228\n32144462\n27090112\n28101681\n33163507\n32014304\n36509901\n31489302\n33661306\n39054212\n38519362\n27073080\n20567921\n16648507\n11910568\n37416742\n38423067\n36244632\n32675481\n35314879\n30238334\n24129824\n21263087\n26968325\n32560632\n38662462",
    "results": "The matched cohort included 78 patients (LVD, n\u00a0=\u00a022; PVE, n\u00a0=\u00a056). Baseline characteristics were comparable. The number of tumors in the whole liver was similar but more LVD patients had five or more tumors in the left liver (32% vs. 11%; p\u00a0=\u00a00.024). Post-procedure sFLR was similar but LVD patients had a significantly higher degree of hypertrophy (16% vs. 11%; p\u00a0=\u00a00.017) and kinetic growth rate (3.9 vs. 2.4% per week; p\u00a0=\u00a00.006). More LVD patients underwent extended right hepatectomy (93% vs. 55%; p\u00a0=\u00a00.008). Only one patient had postoperative hepatic insufficiency after PVE, and no patients died within 90 days of hepatectomy.",
    "title": "Propensity Score-Matched Analysis of Liver Venous Deprivation and Portal Vein Embolization Before Planned Hepatectomy in Patients with Extensive Colorectal Liver Metastases and High-Risk Factors for Inadequate Regeneration.",
    "xml": "<Element 'PubmedArticle' at 0x788502c39c60>"
}