{
    "abstract": "Hypoxia is a significant stressor, and stabilized hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) regulates the expression of numerous genes, leading to various biochemical, molecular, physiological and genomic changes. The body's oxygen-sensing system activates gene expression to protect brain tissues from hypoxia. Gamma-aminobutyric acid, an inhibitory neurotransmitter, regulates brain excitability during hypoxia through the activation of HIF-1 \u03b1. Herbal medicines have been widely used for managing various toxicological effects and disorders including hypoxia; however, the data on safety, efficacy and the molecular mechanisms that increase vulnerability or lethality against hypoxia are still lacking and urgently need to be investigated. The Current study aims to investigate how Bacopa monnieri extract (BME), specially CDRI-08 affects the hippocampus of mice subjected to conditions that simulate hypoxia. The pre and co-treatment of mice involved administrating BME (200\u00a0mg/kg BW) for 14\u00a0days, followed by exposure to CoCl",
    "authors": [
        {
            "affiliation": "Biochemistry and Molecular Biology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221 005, India.",
            "firstname": "Upendra Kumar",
            "initials": "UK",
            "lastname": "Meena"
        },
        {
            "affiliation": "Biochemistry and Molecular Biology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221 005, India. akhilendrakumar@bhu.ac.in.",
            "firstname": "Akhilendra Kumar",
            "initials": "AK",
            "lastname": "Maurya"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
    "doi": "10.1007/s12017-025-08833-5\n10.1177/1177392819866412\n10.4236/jbbs.2013.38063\n10.1006/abio.1976.9999\n10.1038/s41598-020-80045-2\n10.1016/s0891-5849(02)00794-3\n10.1523/JNEUROSCI.5308-07.2008\n10.21769/BioProtoc.4078\n10.3389/fnut.2022.972379\n10.1016/j.neuro.2009.08.012\n10.1016/j.nbd.2008.12.006\n10.1007/s10571-012-9807-5\n10.1186/s12929-022-00878-z\n10.1007/s12035-016-0219-2\n10.1166/jnn.2014.8728\n10.1016/j.brainres.2007.06.106\n10.1242/jeb.01049\n10.1007/s13277-015-3634-5\n10.1007/s11626-018-0309-8\n10.58532/nbennurrdch9\n10.1016/j.biopha.2018.11.019\n10.1016/j.neuropharm.2011.08.040\n10.1002/jat.3749\n10.1007/s00253-022-11834-0\n10.53941/ijddp.2023.100015\n10.1155/2015/347978\n10.3390/ijms222212456\n10.1124/jpet.116.237503\n10.1016/j.pbb.2010.07.017\n10.1038/nrn1408\n10.1007/s11064-014-1489-6\n10.3390/cells11030423\n10.1007/s00421-023-05135-1\n10.1016/j.neurobiolaging.2011.03.019\n10.1016/j.mtbio.2019.01.001\n10.3390/antiox13040393\n10.1016/j.jneuroim.2011.06.001\n10.1038/nprot.2009.197\n10.3390/ijms22136705",
    "journal": "Neuromolecular medicine",
    "keywords": [
        "Bacopa monnieri extract",
        "Anxiety",
        "GABAAR-\u02511",
        "HIF-1\u03b1",
        "Hippocampus",
        "Oxidative stress"
    ],
    "methods": null,
    "publication_date": "2025-01-24",
    "pubmed_id": "39853472\n31391778\n942051\n33436817\n12031889\n18417691\n34327275\n36061899\n19744517\n19154788\n22331403\n36344992\n27785755\n25935977\n17870061\n15299044\n26076811\n21889518\n30484873\n35201388\n26413121\n34830337\n27754930\n20678517\n15152194\n25479948\n35159233\n36690907\n32159136\n38671841\n21807419\n20057381\n34201416",
    "results": null,
    "title": "Bacopa monnieri Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1\u03b1 Signaling and Enhancing the Antioxidant Defense System in Hippocampus.",
    "xml": "<Element 'PubmedArticle' at 0x788504fcbfb0>"
}