{
    "abstract": "Previous studies have linked high-density lipoprotein cholesterol (HDL-C) to gout, but little is known about the dose-effect relationship between serum HDL-C levels and gout flares. This study aimed to quantify the association between the two during urate-lowering therapy initiation and develop a regression equation to predict gout flares.\nWe conducted a prospective, observational, single-center cohort study of men with gout. Patients were identified and grouped according to the level of serum HDL-C (1.16\u00a0mmol/L) at baseline and followed-up every four weeks until 12\u00a0weeks.\nA total of 394 participants completed the study (203 in the low HDL-C group; 191 in the high HDL-C group). The proportion of participants with gout flares in the low HDL-C group was significantly higher than in the high HDL-C group after 12\u00a0weeks follow-up (52.2% versus 35.6%, \nPatients with gout presented a negative linear relationship between serum HDL-C and gout flares. Together with common clinical indicators, the AUC for gout flare prediction increased to 0.75. For patients with gout, remaining serum HDL-C level above 1.15\u00a0mmol/L may reduce the risk of gout flares.",
    "authors": [
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Chang",
            "initials": "C",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Maichao",
            "initials": "M",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Ying",
            "initials": "Y",
            "lastname": "Chen"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Yuwei",
            "initials": "Y",
            "lastname": "He"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Xinde",
            "initials": "X",
            "lastname": "Li"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Lingling",
            "initials": "L",
            "lastname": "Cui"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Han",
            "initials": "H",
            "lastname": "Qi"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Zan",
            "initials": "Z",
            "lastname": "Cheng"
        },
        {
            "affiliation": "Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Xiaoqing",
            "initials": "X",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.\nDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Changgui",
            "initials": "C",
            "lastname": "Li"
        },
        {
            "affiliation": "Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Qingdao, People's Republic of China.\nShandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.\nDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.",
            "firstname": "Jie",
            "initials": "J",
            "lastname": "Lu"
        }
    ],
    "conclusions": "Patients with gout presented a negative linear relationship between serum HDL-C and gout flares. Together with common clinical indicators, the AUC for gout flare prediction increased to 0.75. For patients with gout, remaining serum HDL-C level above 1.15\u00a0mmol/L may reduce the risk of gout flares.",
    "copyrights": "\u00a9 2024 Jiang et al.",
    "doi": "10.2147/JIR.S493376\n10.1038/s41572-019-0115-y\n10.1016/s0140-6736(18)32335-3\n10.1002/art.41453\n10.1016/s0140-6736(21)00569-9\n10.1001/jama.2022.11390\n10.1016/j.soard.2007.09.012\n10.1093/rheumatology/ken471\n10.1002/art.33315\n10.1093/rheumatology/keq037\n10.1371/journal.pone.0228684\n10.1038/s10038-020-00863-0\n10.1136/bmjopen-2023-074541\n10.1136/annrheumdis-2015-208237\n10.3899/jrheum.160452\n10.1016/s0140-6736(03)15268-3\n10.1002/art.40381\n10.7326/0003-4819-150-9-200905050-00006\n10.1136/ard.45.4.308\n10.1093/rheumatology/keac656\n10.1001/jama.2023.26640\n10.2147/jir.S424820\n10.3389/fendo.2022.917056\n10.1186/s13054-020-02860-3\n10.1007/s00134-009-1609-y\n10.1038/nrrheum.2017.155\n10.1161/atvbaha.108.168690\n10.1016/s1568-9972(01)00018-0\n10.1136/annrheumdis-2013-203803",
    "journal": "Journal of inflammation research",
    "keywords": [
        "AUC",
        "inflammation",
        "life style intervention",
        "prediction"
    ],
    "methods": null,
    "publication_date": "2024-12-24",
    "pubmed_id": "39717664\n31558729\n30415748\n33150696\n33798500\n35916846\n17910294\n18065292\n19151029\n22031222\n20202928\n32059030\n33100326\n38341200\n26359487\n28148699\n12046553\n14726171\n29161469\n19414839\n3707219\n36409036\n38319333\n37706063\n35992130\n32264946\n19669126\n28959043\n18617650\n12849067\n24326007",
    "results": "A total of 394 participants completed the study (203 in the low HDL-C group; 191 in the high HDL-C group). The proportion of participants with gout flares in the low HDL-C group was significantly higher than in the high HDL-C group after 12\u00a0weeks follow-up (52.2% versus 35.6%, ",
    "title": "Quantitative Assessment of Baseline Serum HDL-C to Predict Gout Flares During Urate-Lowering Therapy Initiation: A Prospective Cohort Study.",
    "xml": "<Element 'PubmedArticle' at 0x7885034f4310>"
}