{
    "abstract": "Polycystic ovary syndrome (PCOS) is a common, complex reproductive endocrinopathy characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. Lifestyle modification is a first-line intervention; however, there are barriers to success for this form of self-care, and women often seek adjunct therapies including herbal medicines. This pragmatic, randomized controlled trial, delivered in communities of Australia in overweight women with PCOS, compared the effectiveness and safety of a lifestyle intervention plus herbal medicine against lifestyle alone. All participants were helped to construct a personalized lifestyle plan. The herbal intervention consisted of two tablets. Tablet 1 contained Cinnamomum verum, Glycyrrhiza glabra, Hypericum perforatum and Paeonia lactiflora. Tablet 2 contained Tribulus terrestris. The primary outcome was oligomenorrhoea/amenorrhoea. Secondary outcomes were hormones; anthropometry; quality of life; depression, anxiety and stress; pregnancy; birth outcomes; and safety. One hundred and twenty-two women gave their consent. At 3\u00a0months, women in the combination group recorded a reduction in oligomenorrhoea of 32.9% (95% confidence interval 23.3-42.6, p\u00a0<\u00a00.01) compared with controls, estimated as a large effect (\u03b7",
    "authors": [
        {
            "affiliation": "National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.",
            "firstname": "Susan",
            "initials": "S",
            "lastname": "Arentz"
        },
        {
            "affiliation": "National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.",
            "firstname": "Caroline A",
            "initials": "CA",
            "lastname": "Smith"
        },
        {
            "affiliation": "School of Women's and Children's Health, Level 1, Women's Health Institute, Royal Hospital for Women, University of New South Wales, Barker Street, Randwick, NSW, 2031, Australia.",
            "firstname": "Jason",
            "initials": "J",
            "lastname": "Abbott"
        },
        {
            "affiliation": "School of Science and Health, Western Sydney University, Building 24, Locked Bag 1797, Penrith, NSW, 2751, Australia.",
            "firstname": "Paul",
            "initials": "P",
            "lastname": "Fahey"
        },
        {
            "affiliation": "National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.\nSchool of Science and Health, Western Sydney University, Building 24, Locked Bag 1797, Penrith, NSW, 2751, Australia.",
            "firstname": "Birinder S",
            "initials": "BS",
            "lastname": "Cheema"
        },
        {
            "affiliation": "National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.",
            "firstname": "Alan",
            "initials": "A",
            "lastname": "Bensoussan"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2017 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.",
    "doi": "10.1002/ptr.5858\n10.1136/bmjopen-2016-011709\n10.1093/humrep/det256\n10.1002/14651858\n10.1002/14651858.CD007535.pub2",
    "journal": "Phytotherapy research : PTR",
    "keywords": [
        "herbal therapeutics",
        "lifestyle",
        "menstrual regulation",
        "overweight",
        "polycystic ovary syndrome",
        "safety"
    ],
    "methods": null,
    "publication_date": "2017-07-08",
    "pubmed_id": "28685911\n25524718\n25481654\n15579328\n17113210\n18446848\n15944216\n16378915\n17253562\n9626128\n12727935\n14711538\n22147920\n17291355\n10647752\n19585478\n17684134\n21505350\n15302293\n26887532\n23347605\n10902785\n24813595\n28159846\n17287476\n17403436\n18843608\n19910321\n20484445\n25846125\n30921477\n23420000\n23771201\n10999803\n17965792\n15639683\n24592984\n11545683\n8012442\n22592687\n20591140\n15655038\n18583464\n10521203\n17296187\n22236320\n18316340\n7108310\n20824862\n20824862\n19001484",
    "results": null,
    "title": "Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.",
    "xml": "<Element 'PubmedArticle' at 0x788505f27c90>"
}