{
    "abstract": "Vascularization and inflammation management are essential for successful bone regeneration during the healing process of large bone defects assisted by artificial implants/fillers. Therefore, this study is devoted to the optimization of the osteogenic microenvironment for accelerated bone healing through rapid neovascularization and appropriate inflammation inhibition that were achieved by applying a tantalum oxide (TaO)-based nanoplatform carrying functional substances at the bone defect. Specifically, TaO mesoporous nanospheres were first constructed and then modified by functionalized metal ions (Mg",
    "authors": [
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Zheng",
            "initials": "Z",
            "lastname": "Liu"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Leizhen",
            "initials": "L",
            "lastname": "Huang"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Lin",
            "initials": "L",
            "lastname": "Qi"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Jing",
            "initials": "J",
            "lastname": "Wang"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Huilun",
            "initials": "H",
            "lastname": "Xu"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Hao",
            "initials": "H",
            "lastname": "Yang"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Limin",
            "initials": "L",
            "lastname": "Liu"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Ganjun",
            "initials": "G",
            "lastname": "Feng"
        },
        {
            "affiliation": "Analytical & Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.",
            "firstname": "Li",
            "initials": "L",
            "lastname": "Zhang"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1021/acsami.4c04316",
    "journal": "ACS applied materials & interfaces",
    "keywords": [
        "angiogenesis",
        "bone regeneration",
        "drug delivery",
        "inflammation management",
        "tantalum"
    ],
    "methods": null,
    "publication_date": "2024-05-06",
    "pubmed_id": "38709640",
    "results": null,
    "title": "Activating Angiogenesis and Immunoregulation to Propel Bone Regeneration ",
    "xml": "<Element 'PubmedArticle' at 0x7885009158f0>"
}