{
    "abstract": "Introduction\u00a0 Takotsubo cardiomyopathy (TCM) is a poorly understood condition typically characterized by abnormal left ventricular wall motion without causative coronary artery disease and typically presents in post-menopausal women after the experience of a physical or emotional stressor. The pathophysiology of TCM is complex and multifactorial, resulting in complications with varied severity; one of the most concerning complications is thromboembolism, specifically, pulmonary embolism (PE), which is understudied in its relation to TCM.\u00a0The purpose of this study was to characterize and evaluate the real-world prevalence and outcomes of PE in TCM. Methods\u00a0 Data were derived from the National Inpatient Sample database from January 2016 to December 2019. The primary outcomes assessed were baseline and hospital admission characteristics and comorbidities for patients with TCM with and without PE. Outcomes for TCM patients with PE\u00a0and predictors of mortality in TCM were also analyzed. Results\u00a0 PE developed in 788 of 40,120 patients with TCM (1.96%). After multivariate adjustment, PE was found to be independently associated with intracardiac thrombus (adjusted odds ratio (aOR) 2.067; 95% confidence interval (CI): 1.198-3.566; p = 0.009) and right heart catheterization (RHC) (aOR: 1.971; 95% CI: 1.160-3.350; p = 0.012). Mortality in patients with TCM was associated with, among other factors, age in years at admission (aOR: 1.104; 95% CI: 1.010-1.017; p = 0.001), African American race (aOR: 1.191; 95% CI: 1.020-1.391; p = 0.027), Asian or Pacific Islander race (aOR: 1.637; 95% CI: 1.283-2.090; p = 0.001), coagulopathy (aOR: 3.393; 95% CI: 2.889-2.986; p = 0.001), liver disease (aOR: 1.446; 95% CI: 1.147-1.824; p = 0.002), atrial fibrillation (aOR: 1.460; 95% CI: 1.320-1.615; p = 0.001), and pulmonary embolism (aOR: 2.217; 95% CI: 1.781-2.760; p = 0.001). Conclusion\u00a0 In a large cohort of patients admitted with TCM,\u00a0we found the prevalence of PE to be 1.96%. PE, along with comorbidities such as coagulopathy and atrial fibrillation, was found to be a significant predictor\u00a0of mortality in this patient cohort.",
    "authors": [
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Omar",
            "initials": "O",
            "lastname": "Elkattawy"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Antonia",
            "initials": "A",
            "lastname": "Sames"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Sruthi",
            "initials": "S",
            "lastname": "Kunamneni"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Riya",
            "initials": "R",
            "lastname": "Sutariya"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Mohamed",
            "initials": "M",
            "lastname": "Ismail"
        },
        {
            "affiliation": "Medicine, Saint Barnabas Medical Center, Livingston, USA.",
            "firstname": "Omar",
            "initials": "O",
            "lastname": "Mohamed"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Thomas J",
            "initials": "TJ",
            "lastname": "Lee"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Jahanzeb",
            "initials": "J",
            "lastname": "Javed"
        },
        {
            "affiliation": "Cardiology, Saint Joseph's University Medical Center, Paterson, USA.",
            "firstname": "Sherif",
            "initials": "S",
            "lastname": "Elkattawy"
        },
        {
            "affiliation": "Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.",
            "firstname": "Afif",
            "initials": "A",
            "lastname": "Hossain"
        },
        {
            "affiliation": "Cardiology, Saint Joseph's University Medical Center, Paterson, USA.",
            "firstname": "Fayez",
            "initials": "F",
            "lastname": "Shamoon"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024, Elkattawy et al.",
    "doi": "10.7759/cureus.59268",
    "journal": "Cureus",
    "keywords": [
        "cardio-obstetrics",
        "cardiology",
        "preventive cardiology",
        "pulmonary embolism",
        "takotsubo cardiomyopathy"
    ],
    "methods": null,
    "publication_date": "2024-05-30",
    "pubmed_id": "38813344\n37183265\n27928880\n35002350\n35040000\n33602474\n30565272\n34362223\n34659930\n30526522\n35625378\n26317750\n25068020\n19303496\n32762456\n36946153\n30953632\n36536603\n33833932\n18066546\n26421898\n33238332\n36270343\n28606950",
    "results": null,
    "title": "Pulmonary Embolism in Patients Admitted With Takotsubo Cardiomyopathy: Prevalence and Associated In-Hospital Adverse Events.",
    "xml": "<Element 'PubmedArticle' at 0x7885061ea340>"
}