{
    "abstract": "Massive proliferation of some toxic marine dinoflagellates is responsible for the occurrence of harmful algal blooms and the contamination of fish and shellfish worldwide. Pinnatoxins (PnTx) (A-H) comprise an emerging phycotoxin family belonging to the cyclic imine toxin group. Interest has been focused on these lipophilic, fast-acting and highly potent toxins because they are widely found in contaminated shellfish, and can represent a risk for seafood consumers. PnTx display a potent antagonist effect on nicotinic acetylcholine receptors (nAChR), and in this study we assessed in vivo the ability of PnTx-G to cross physiological barriers to reach its molecular target. Radiolabeled [",
    "authors": [
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France. Electronic address: denis.servent@cea.fr.",
            "firstname": "Denis",
            "initials": "D",
            "lastname": "Servent"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Carole",
            "initials": "C",
            "lastname": "Malgorn"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Myl\u00e8ne",
            "initials": "M",
            "lastname": "Bernes"
        },
        {
            "affiliation": "Universit\u00e9 de Paris, UMR-S1139, Facult\u00e9 de Pharmacie de Paris, France.",
            "firstname": "Sophie",
            "initials": "S",
            "lastname": "Gil"
        },
        {
            "affiliation": "Universit\u00e9 de Paris, UMR-S1139, Facult\u00e9 de Pharmacie de Paris, France.",
            "firstname": "Christelle",
            "initials": "C",
            "lastname": "Simasotchi"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, UMR9199, CNRS, CEA, MIRCen, Fontenay-aux-Roses, France.",
            "firstname": "Anne-Sophie",
            "initials": "AS",
            "lastname": "H\u00e9rard"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, UMR9199, CNRS, CEA, MIRCen, Fontenay-aux-Roses, France.",
            "firstname": "Thierry",
            "initials": "T",
            "lastname": "Delzescaux"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Robert",
            "initials": "R",
            "lastname": "Thai"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Peggy",
            "initials": "P",
            "lastname": "Barbe"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Mathilde",
            "initials": "M",
            "lastname": "Keck"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Fabrice",
            "initials": "F",
            "lastname": "Beau"
        },
        {
            "affiliation": "University of California, Santa Barbara, Department of Chemistry and Biochemistry, CA 93106-9510, USA.",
            "firstname": "Armen",
            "initials": "A",
            "lastname": "Zakarian"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.",
            "firstname": "Vincent",
            "initials": "V",
            "lastname": "Dive"
        },
        {
            "affiliation": "Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France. Electronic address: jordi.molgo@cea.fr.",
            "firstname": "Jordi",
            "initials": "J",
            "lastname": "Molg\u00f3"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2021 The Authors. Published by Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.scitotenv.2021.148125",
    "journal": "The Science of the total environment",
    "keywords": [
        "Cyclic imine toxins",
        "Digital autoradiography",
        "Harmful algal bloom",
        "Nicotinic acetylcholine receptors",
        "Pinnatoxins",
        "Toxicokinetics"
    ],
    "methods": null,
    "publication_date": "2021-08-13",
    "pubmed_id": "34380275",
    "results": null,
    "title": "First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier.",
    "xml": "<Element 'PubmedArticle' at 0x788506545670>"
}