{
    "abstract": "To investigate the association between assisted reproductive technology (ART) use and childhood cancer subtype.\nWe deployed a cross-sectional survey of 1701 parents of children with cancer about their ART use, demographics, and gestational and perinatal factors. Multivariable logistic regression modeled the association between ART use, birthweight and multiple gestation status with childhood cancer, by subtype.\nART use was highest among children with osteosarcoma relative to children with other cancer types, and this association was statistically significant in multivariable models (OR\u00a0=\u00a04.4; 95% CI\u00a0=\u00a01.7-11.3; p\u00a0=\u00a00.0020). ART use was also elevated among children with hepatoblastoma, but this relationship appeared to be due to the strong associations between ART use and lower birthweight in our sample. No specific ART modality appeared to drive these associations. In univariate models, multiple gestation was associated with a 2.7-fold increased odds of hepatoblastoma (OR\u00a0=\u00a02.71; 95% CI\u00a0=\u00a01.14-6.42; p\u00a0=\u00a00.02) and a 1.6-fold increased odds of neuroblastoma (OR\u00a0=\u00a01.62; 95% CI\u00a0=\u00a01.03-2.54; p\u00a0=\u00a00.03), but these associations were not retained in multivariable models.\nAssociations between ART use and hepatoblastoma risk may be attributable to birthweight, a known hepatoblastoma risk factor. ART use may also be associated with osteosarcoma, independent of birthweight, an association not previously observed in studies limited to cancers diagnosed before adolescence. Evaluating long-term health outcomes in children conceived by ART, throughout adolescence and potentially into adulthood, appears warranted.",
    "authors": [
        {
            "affiliation": "Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Natalie B",
            "initials": "NB",
            "lastname": "Gulrajani"
        },
        {
            "affiliation": "Master of Biomedical Sciences Program, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Samuel",
            "initials": "S",
            "lastname": "Montes"
        },
        {
            "affiliation": "Master of Biomedical Sciences Program, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Daniel",
            "initials": "D",
            "lastname": "McGough"
        },
        {
            "affiliation": "Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Courtney E",
            "initials": "CE",
            "lastname": "Wimberly"
        },
        {
            "affiliation": "Master of Biomedical Sciences Program, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Ameera",
            "initials": "A",
            "lastname": "Khattab"
        },
        {
            "affiliation": "Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Eleanor C",
            "initials": "EC",
            "lastname": "Semmes"
        },
        {
            "affiliation": "My Childhood Cancer Program, Alex's Lemonade Stand Foundation, Bala Cynwyd, Pennsylvania, USA.",
            "firstname": "Lisa",
            "initials": "L",
            "lastname": "Towry"
        },
        {
            "affiliation": "Division of Medical Genetics, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Jennifer L",
            "initials": "JL",
            "lastname": "Cohen"
        },
        {
            "affiliation": "Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Jillian H",
            "initials": "JH",
            "lastname": "Hurst"
        },
        {
            "affiliation": "Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Daniel",
            "initials": "D",
            "lastname": "Landi"
        },
        {
            "affiliation": "Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.\nFrank Porter Graham Child Development Institute, The University of North Carolina, Chapel Hill, North Carolina, USA.",
            "firstname": "Sherika N",
            "initials": "SN",
            "lastname": "Hill"
        },
        {
            "affiliation": "Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.\nDepartment of Neurosurgery and Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, North Carolina, USA.\nDuke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Kyle M",
            "initials": "KM",
            "lastname": "Walsh"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",
    "doi": "10.1002/cam4.5114",
    "journal": "Cancer medicine",
    "keywords": [
        "assisted reproductive technology",
        "cancer risk factors",
        "epidemiology",
        "in vitro fertilization",
        "liver cancer",
        "osteosarcoma",
        "pediatric cancer"
    ],
    "methods": null,
    "publication_date": "2022-08-06",
    "pubmed_id": "35929579\n24488779\n24853691\n18074355\n27351365\n30411179\n32864610\n3969117\n25626438\n10852857\n30996022\n27979823\n31821431\n30933244\n24195549\n14742347\n19833428\n22559061\n24602756\n32445067\n33565259\n32607579\n12869410\n12189554\n30548591\n29106578\n30311632\n27860191\n26951653\n16782807\n31355930\n19564288\n18392049\n23558166\n26945609\n26875948",
    "results": "ART use was highest among children with osteosarcoma relative to children with other cancer types, and this association was statistically significant in multivariable models (OR\u00a0=\u00a04.4; 95% CI\u00a0=\u00a01.7-11.3; p\u00a0=\u00a00.0020). ART use was also elevated among children with hepatoblastoma, but this relationship appeared to be due to the strong associations between ART use and lower birthweight in our sample. No specific ART modality appeared to drive these associations. In univariate models, multiple gestation was associated with a 2.7-fold increased odds of hepatoblastoma (OR\u00a0=\u00a02.71; 95% CI\u00a0=\u00a01.14-6.42; p\u00a0=\u00a00.02) and a 1.6-fold increased odds of neuroblastoma (OR\u00a0=\u00a01.62; 95% CI\u00a0=\u00a01.03-2.54; p\u00a0=\u00a00.03), but these associations were not retained in multivariable models.",
    "title": "Assisted reproductive technology and association with childhood cancer subtypes.",
    "xml": "<Element 'PubmedArticle' at 0x788502bf3d80>"
}