{
    "abstract": "The aim of this study was to analyze the outcomes of newborns with Down syndrome admitted to three neonatal intensive care units in the city of Rio de Janeiro, Brazil.\nA retrospective cohort study was conducted by analyzing the medical records between 2014 and 2018 of newborns with Down syndrome admitted to three neonatal intensive care units. The following variables were analyzed: maternal and perinatal data, neonatal malformations, neonatal intensive care unit intercurrences, and outcomes.\nA total of 119 newborns with Down syndrome were recruited, and 112 were selected for analysis. The most common maternal age group was >35 years (72.07%), the most common type of delivery was cesarean section (83.93%), and the majority of cases were male (53.57%). The most common reasons for neonatal intensive care unit hospitalization were congenital heart disease (57.66%) and prematurity (23.21%). The most common form of feeding was a combination of human milk and formula (83.93%). The second most common malformation was duodenal atresia (9.82%). The most common complications during neonatal intensive care unit hospitalization were transient tachypnea of the newborn (63.39%), hypoglycemia (18.75%), pulmonary hypertension (7.14%), and sepsis (7.14%). The mean length of stay in the neonatal intensive care unit was 27 days. The most common outcome was discharge (82.14%). Furthermore, 12.50% of newborns were transferred to an external neonatal intensive care unit, and 6% died.\nNewborns with Down syndrome are more likely to be admitted to the neonatal intensive care unit, and the length of hospital stay is longer due to complications related to congenital malformations common to this syndrome and prematurity.",
    "authors": [
        {
            "affiliation": "Fernandes Figueira Institute, Oswaldo Cruz Foundation, Department of Obstetrics and Fetal Medicine - Rio de Janeiro (RJ), Brazil.",
            "firstname": "Hanna Gabriela da Cruz",
            "initials": "HGDC",
            "lastname": "Alfaro"
        },
        {
            "affiliation": "Fernandes Figueira Institute, Oswaldo Cruz Foundation, Department of Obstetrics and Fetal Medicine - Rio de Janeiro (RJ), Brazil.",
            "firstname": "Saint Clair",
            "initials": "SC",
            "lastname": "Gomes Junior"
        },
        {
            "affiliation": "Fernandes Figueira Institute, Oswaldo Cruz Foundation, Department of Obstetrics and Fetal Medicine - Rio de Janeiro (RJ), Brazil.\nUniversidade Federal Fluminense, Department of Obstetrics - Niter\u00f3i (RJ), Brazil.",
            "firstname": "Renato Augusto Moreira de",
            "initials": "RAM",
            "lastname": "S\u00e1"
        },
        {
            "affiliation": "Universidade Federal de S\u00e3o Paulo, Paulista School of Medicine, Department of Obstetrics - S\u00e3o Paulo (SP), Brazil.\nUniversidade Municipal de S\u00e3o Caetano do Sul, Discipline of Woman Health - S\u00e3o Paulo (SP), Brazil.",
            "firstname": "Edward",
            "initials": "E",
            "lastname": "Araujo J\u00fanior"
        }
    ],
    "conclusions": "Newborns with Down syndrome are more likely to be admitted to the neonatal intensive care unit, and the length of hospital stay is longer due to complications related to congenital malformations common to this syndrome and prematurity.",
    "copyrights": null,
    "doi": "10.1590/1806-9282.20231186\n10.4070/kcj.2015.45.5.357\n10.1590/1516-3180.2015.00710108\n10.4067/S0370-41062017000500016\n10.1001/archsurg.133.5.490\n10.1002/ajmg.a.61258\n10.1016/0753-3322(93)90056-q\n10.5830/CVJA-2016-019\n10.1016/j.jpeds.2017.09.046\n10.1002/bdra.23513\n10.1186/s12884-020-03394-w\n10.1002/uog.3893\n10.1542/peds.2009-3245\n10.4103/aam.aam_57_20\n10.1097/00004836-198604000-00002\n10.1038/s41372-018-0136-5\n10.1016/S2352-4642(19)30400-6",
    "journal": "Revista da Associacao Medica Brasileira (1992)",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-04-24",
    "pubmed_id": "38656004\n26413101\n26648279\n29546955\n9605910\n31183986\n8018834\n27805241\n29174996\n27301559\n33228595\n17171632\n20624800\n34893563\n2943789\n29795453\n32450124",
    "results": "A total of 119 newborns with Down syndrome were recruited, and 112 were selected for analysis. The most common maternal age group was >35 years (72.07%), the most common type of delivery was cesarean section (83.93%), and the majority of cases were male (53.57%). The most common reasons for neonatal intensive care unit hospitalization were congenital heart disease (57.66%) and prematurity (23.21%). The most common form of feeding was a combination of human milk and formula (83.93%). The second most common malformation was duodenal atresia (9.82%). The most common complications during neonatal intensive care unit hospitalization were transient tachypnea of the newborn (63.39%), hypoglycemia (18.75%), pulmonary hypertension (7.14%), and sepsis (7.14%). The mean length of stay in the neonatal intensive care unit was 27 days. The most common outcome was discharge (82.14%). Furthermore, 12.50% of newborns were transferred to an external neonatal intensive care unit, and 6% died.",
    "title": "Analysis of Down syndrome newborn outcomes in three neonatal intensive care units in Rio de Janeiro, Brazil.",
    "xml": "<Element 'PubmedArticle' at 0x788502c8aed0>"
}