{
    "abstract": "Patients with a history of endometriosis have an increased risk of developing various autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis and celiac disease. There is a potential association between endometriosis and an increased susceptibility for Sj\u00f6gren's syndrome (SS). SS is a common chronic, inflammatory, systemic, autoimmune, multifactorial disease of complex pathology, with genetic, epigenetic and environmental factors contributing to the development of this condition. It occurs in 0.5\u20111% of the population, is characterized by the presence of ocular dryness, lymphocytic infiltrations and contributes to neurological, gastrointestinal, vascular and dermatological manifestations. Endometriosis is an inflammatory, estrogen\u2011dependent, multifactorial, heterogeneous gynecological disease, affecting \u226410% of reproductive\u2011age women. It is characterized by the occurrence of endometrial tissue outside the uterine cavity, mainly in the pelvic cavity, and is associated with pelvic pain, dysmenorrhea, deep dyspareunia and either subfertility or infertility. It is still unclear whether SS appears as a secondary response to endometriosis, or it is developed due to any potential shared mechanisms of these conditions. The aim of the present review was to explore further the biological basis only of the co\u2011occurrence of these disorders but not their association at clinical basis, focusing on the analysis of the partially shared genetic background between endometriosis and SS, and the clarification of the possible similarities in the underlying pathogenetic mechanisms and the relevant molecular pathways.",
    "authors": [
        {
            "affiliation": "Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71403 Heraklion, Greece.",
            "firstname": "Maria I",
            "initials": "MI",
            "lastname": "Zervou"
        },
        {
            "affiliation": "First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.",
            "firstname": "Basil C",
            "initials": "BC",
            "lastname": "Tarlatzis"
        },
        {
            "affiliation": "Unit for Human Reproduction, First Department of Obstetrics and Gynecology, 'Papageorgiou' General Hospital, Aristotle University Medical School, 56403 Thessaloniki, Greece.",
            "firstname": "Grigoris F",
            "initials": "GF",
            "lastname": "Grimbizis"
        },
        {
            "affiliation": "Laboratory of Clinical Virology, School of Medicine, University of Crete, 71403 Heraklion, Greece.",
            "firstname": "Demetrios A",
            "initials": "DA",
            "lastname": "Spandidos"
        },
        {
            "affiliation": "Barbara Volcker Center for Women and Rheumatic Disease, New York, NY 10021, USA.",
            "firstname": "Timothy B",
            "initials": "TB",
            "lastname": "Niewold"
        },
        {
            "affiliation": "Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71403 Heraklion, Greece.",
            "firstname": "George N",
            "initials": "GN",
            "lastname": "Goulielmos"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3892/ijmm.2024.5344",
    "journal": "International journal of molecular medicine",
    "keywords": [
        "Sj\u00f6gren's syndrome",
        "autoimmunity",
        "endometriosis",
        "gene polymorphisms",
        "genetics",
        "inflammation"
    ],
    "methods": null,
    "publication_date": "2024-01-08",
    "pubmed_id": "38186322\n29514034\n19745687\n10446879\n16932699\n7980676\n10320647\n3021847\n23719365\n21489323\n30452329\n30994890\n11949952\n11870102\n18535005\n30054239\n15947176\n21747346\n7377252\n20801404\n33132854\n15200766\n31836436\n29276652\n25765863\n34754275\n36799179\n30070938\n31260048\n35258592\n35784295\n36960867\n36902830\n21471158\n31425004\n35592328\n10202882\n26209831\n16080113\n17705887\n23104006\n22910690\n24639062\n24676469\n26337243\n28537267\n30026507\n28901453\n29328375\n28333195\n30628680\n30988702\n36914876\n32165309\n22138541\n21925322\n26934855\n29259483\n31752018\n24138928\n28476436\n3801073\n10374300\n25261962\n8340232\n15022331\n8193233\n29649576\n24097067\n24097066\n28076899\n12453311\n28640813\n22330229\n35896530\n16477017\n18581327\n12763528\n7926125\n28927243\n24811097\n8612850\n14581858\n19568172\n20683439\n20236834\n8875029\n1370583\n8702447\n16183246\n18684981\n18311793\n19700754\n1343766\n11326474\n15251127\n32506205\n28099084\n9458209\n11491496\n10711829\n21848410\n10461001\n10835101\n11806246\n11329059\n9688413\n8782456\n22332753\n36362017\n23031691\n15963249\n18818406\n22513453\n20191479\n22237885\n30336792\n22222816\n19092842\n30887509\n27235632\n20535138\n20070289\n36028805\n23723980\n26773192\n35472084\n12721173\n22001416\n12392856\n10779770\n18682104\n17804842\n19109131\n19371230\n20339793\n25259415\n11244049\n22412986\n21240265\n18050197\n22088620\n21085203\n24657515\n28185859\n24476815\n16461343\n10068674\n16163373\n9874568\n16760194\n15004560\n8209672\n23143596\n25849893\n19440814\n17395783\n31961910\n12765345\n29901577\n12791978\n16254005\n31936322\n10036639\n1686751\n1909694\n1723064\n11303306\n11899152\n7589633\n8189070\n26644856\n11438312\n8994869\n21616679\n15731320\n11949940\n16759923\n15599664\n11292861\n25367569\n22009797\n27445820\n27032396\n11526493\n21871655\n26604208\n26183766\n12919954\n10541802\n29967481\n36308435\n25017104\n21592778\n26771608\n21420027\n26943802\n24991561\n26888739\n33909757\n34208031\n32850438\n29977932\n23362326\n30602080\n28828000\n29387196\n20457282\n27179784\n30873941\n28916716\n30909166\n29201189\n29149541\n30231774\n32376798\n24931100\n37107175\n30608536\n27142093\n22208659\n25128511\n25386850\n29857988\n27323121\n23203215\n18632605\n19893619\n33854480\n24212931\n27099782\n28506024\n32664383\n34506261\n23725124\n25360821\n23118427\n19840932\n21178010\n20850013\n19965651\n19525145\n22033216\n33446013\n22414910\n21450750\n23592263\n26854065\n22215621\n26198055\n21632209\n27693002\n27121304\n19931339\n34843004\n12917783\n3494842\n11476764\n19606257\n15531877\n35160066\n17911037\n25145755\n33216905\n25750101\n33693775\n10690897\n33331948\n8393046\n12372447\n14705226\n15248223\n18198195\n15077311\n16517562",
    "results": null,
    "title": "Association of endometriosis with Sj\u00f6gren's syndrome: Genetic insights (Review).",
    "xml": "<Element 'PubmedArticle' at 0x788502f5a160>"
}