{
    "abstract": "Menopause is associated with reduced nitric oxide (NO) bioavailability, a key contributor to increased arterial stiffness and, consequently, greater risk of cardiovascular disease-related mortality in postmenopausal females. Even though dietary nitrate has been shown to increase NO bioavailability in postmenopausal females acutely, previous studies showed no impact of dietary nitrate supplementation on arterial stiffness in postmenopausal females. Their findings were likely limited by the acute and/or short-term design. Thus, this study aimed to determine whether 12 wk of dietary nitrate supplementation via beetroot extract improves carotid artery stiffness in postmenopausal females. A randomized, double-blind, placebo-controlled, and parallel-design trial was conducted with 20 postmenopausal females (60-85 yr). Participants received nitrate-rich (NR-BEETx, 8.8 mmol/day) or nitrate-depleted (ND-BEETx) beetroot extract. Carotid stiffness parameters-pulse wave velocity (PWV\u03b2), \u03b2 stiffness, pressure-strain elastic modulus, augmentation index (AIx), and arterial compliance-were measured at baseline and ",
    "authors": [
        {
            "affiliation": "Food and Nutrition Institute, Multidisciplinary Center UFRJ-Maca\u00e9, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.",
            "firstname": "Vivian Dos Santos",
            "initials": "VDS",
            "lastname": "Pinheiro"
        },
        {
            "affiliation": "Integrative Vascular Physiology Lab, Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania, United States.",
            "firstname": "David N",
            "initials": "DN",
            "lastname": "Proctor"
        },
        {
            "affiliation": "Division of Kinesiology, Health, and Sports Studies, Wayne State University, Detroit, Michigan, United States.",
            "firstname": "Rogerio",
            "initials": "R",
            "lastname": "Nogueira Soares"
        },
        {
            "affiliation": "Food and Nutrition Institute, Multidisciplinary Center UFRJ-Maca\u00e9, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.",
            "firstname": "Thiago Silveira",
            "initials": "TS",
            "lastname": "Alvares"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1152/ajpheart.00065.2025",
    "journal": "American journal of physiology. Heart and circulatory physiology",
    "keywords": [
        "artery stiffness",
        "beetroot extract",
        "cardiovascular risk",
        "postmenopausal females",
        "vascular aging"
    ],
    "methods": null,
    "publication_date": "2025-03-12",
    "pubmed_id": "40066813",
    "results": null,
    "title": "Effect of 12-wk dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females.",
    "xml": "<Element 'PubmedArticle' at 0x78850430abb0>"
}