{
    "abstract": "Traditional Chinese Medicine (TCM) theory posits a close relationship between an individual's constitutional types and the overall health. Variations in metabolic processes and microbial composition have been observed across different constitution types. This study aims to explore the relationship between TCM constitutions, intestinal flora, and metabolites to devise personalized TCM treatment strategies, enhancing evidence-based guidance for clinical practice.\nThe research investigated differences in microbial diversity and composition among three TCM constitution types: yin-deficiency constitution (PA), balanced constitution (PH), and yang-deficiency constitution (PI). A significant elevation of the Chao1 metric was noted in the PH group compared to the PI group.\nPCoA and CPCoA analyses demonstrated distinct group separation based on floral samples. Dominant phyla included Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Fusobacteria, with varying abundance at the genus level. Metabolic pathway analysis unveiled disparities in metabolites associated with different pathways among constitution groups. KEGG pathway enrichment analysis emphasized pathways such as steroid hormone biosynthesis, ovarian steroidogenesis, and tryptophan metabolism. Furthermore, correlation analysis revealed associations between specific bacterial taxa and metabolites.\nThis study delineated the variations in intestinal flora and metabolic profiles among individuals with PA, PH, and PI constitution types, providing valuable insights for the development of personalized TCM treatment approaches.",
    "authors": [
        {
            "affiliation": "Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China.",
            "firstname": "Na",
            "initials": "N",
            "lastname": "Song"
        },
        {
            "affiliation": "Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Hunan University of Chinese Medicine, 4102082, Hunan, China.",
            "firstname": "Xinyi",
            "initials": "X",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Hunan University of Chinese Medicine, 4102082, Hunan, China.",
            "firstname": "Pingyu",
            "initials": "P",
            "lastname": "Liu"
        },
        {
            "affiliation": "Physical Examination Center, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China.",
            "firstname": "Yutong",
            "initials": "Y",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China.",
            "firstname": "Xiaohui",
            "initials": "X",
            "lastname": "Tang"
        },
        {
            "affiliation": "Department of Rehabilitation Medicine, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Chongqing Precision Medical Industry Technology Research Institute, Chongqing 400000, China. Electronic address: deyuzhou@qq.com.",
            "firstname": "Deyu",
            "initials": "D",
            "lastname": "Zuo"
        },
        {
            "affiliation": "Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China. Electronic address: zonglanglai@qq.com.",
            "firstname": "Zonglang",
            "initials": "Z",
            "lastname": "Lai"
        },
        {
            "affiliation": "Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Shapingba District Hospital of TCM, Chongqing, 400030, China. Electronic address: juncheng@finmail.com.",
            "firstname": "Jun",
            "initials": "J",
            "lastname": "Cheng"
        }
    ],
    "conclusions": "This study delineated the variations in intestinal flora and metabolic profiles among individuals with PA, PH, and PI constitution types, providing valuable insights for the development of personalized TCM treatment approaches.",
    "copyrights": "Copyright \u00a9 2025. Published by Elsevier Ltd.",
    "doi": "10.1016/j.micpath.2025.107621",
    "journal": "Microbial pathogenesis",
    "keywords": [
        "16S rDNA",
        "Intestinal flora",
        "Metabolites",
        "Non-targeted metabolomics",
        "TCM constitutions"
    ],
    "methods": null,
    "publication_date": "2025-04-22",
    "pubmed_id": "40258500",
    "results": "PCoA and CPCoA analyses demonstrated distinct group separation based on floral samples. Dominant phyla included Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Fusobacteria, with varying abundance at the genus level. Metabolic pathway analysis unveiled disparities in metabolites associated with different pathways among constitution groups. KEGG pathway enrichment analysis emphasized pathways such as steroid hormone biosynthesis, ovarian steroidogenesis, and tryptophan metabolism. Furthermore, correlation analysis revealed associations between specific bacterial taxa and metabolites.",
    "title": "Integrative Analysis of Microbiota and Metabolomics in Individuals Exhibiting Different TCM Constitutions Utilizing 16S rDNA Sequencing and LC/MS Metabolomics.",
    "xml": "<Element 'PubmedArticle' at 0x788505ffe890>"
}