{
    "abstract": "The negative effects of ionizing radiation on organs and the reproductive system are well known and documented. Exposure to gamma radiation can lead to oligospermia, azoospermia and DNA damage. Up to date, there is no effective pharmaceutical compound for protecting the male reproductive system and sperm.\nThis study aimed at investigating the ability of \u0190-aminocaproic acid (EACA) to prevent the damage of human spermatozoa and DNA induced by ionizing radiation.\nSperm samples were obtained from healthy volunteers (35 men; 31.50\u2009\u00b1\u20097.34\u2009years old). There were four experimental groups: (1) control group (CG), (2) group exposed to maximal radiation dose 67.88 mGy (RMAX), (3) low-dose radiation (minimal) 22.62 mGy (RMIN), and (4) group treated with radiation (67.88 mGy) and EACA (dose 50\u2009ng/mL). Sperm motility, viability, and DNA damage were assessed.\nWe observed a significant decrease in total sperm motility of the RMAX group compared to CG (\nThe results indicate that EACA effectively protects human spermatozoa from DNA damage induced by ionizing radiation. Treatment of spermatozoa with EACA led to the preservation of cell motility, viability, and DNA integrity upon radiation exposure.",
    "authors": [
        {
            "affiliation": "S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.",
            "firstname": "Timur",
            "initials": "T",
            "lastname": "Saliev"
        },
        {
            "affiliation": "S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.",
            "firstname": "Ildar",
            "initials": "I",
            "lastname": "Fakhradiyev"
        },
        {
            "affiliation": "S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.",
            "firstname": "Shynar",
            "initials": "S",
            "lastname": "Tanabayeva"
        },
        {
            "affiliation": "F.M. Muhamedgaliev Institute of Experimental Biology, Almaty, Kazakhstan.",
            "firstname": "Yelena",
            "initials": "Y",
            "lastname": "Assanova"
        },
        {
            "affiliation": "F.M. Muhamedgaliev Institute of Experimental Biology, Almaty, Kazakhstan.\nEmbryo Technology Labs, Almaty, Kazakhstan.",
            "firstname": "Dinmukhamed",
            "initials": "D",
            "lastname": "Toishybek"
        },
        {
            "affiliation": "S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.\nClinic of Reproduction and Anti Age, Almaty, Kazakhstan.",
            "firstname": "Aigul",
            "initials": "A",
            "lastname": "Kazybayeva"
        },
        {
            "affiliation": "South- Kazakhstan Medical Academy, Shymkent, Kazakhstan.",
            "firstname": "Baimakhan",
            "initials": "B",
            "lastname": "Tanabayev"
        },
        {
            "affiliation": "S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.",
            "firstname": "Marat",
            "initials": "M",
            "lastname": "Sikhymbaev"
        },
        {
            "affiliation": "NCJSC Semey Medical University, Semey, Kazakhstan.",
            "firstname": "Aliya",
            "initials": "A",
            "lastname": "Alimbayeva"
        },
        {
            "affiliation": "F.M. Muhamedgaliev Institute of Experimental Biology, Almaty, Kazakhstan.\nEmbryo Technology Labs, Almaty, Kazakhstan.",
            "firstname": "Yerzhan",
            "initials": "Y",
            "lastname": "Toishibekov"
        }
    ],
    "conclusions": "The results indicate that EACA effectively protects human spermatozoa from DNA damage induced by ionizing radiation. Treatment of spermatozoa with EACA led to the preservation of cell motility, viability, and DNA integrity upon radiation exposure.",
    "copyrights": null,
    "doi": "10.1080/09553002.2022.2027540",
    "journal": "International journal of radiation biology",
    "keywords": [
        "DNA",
        "Ionizing radiation",
        "aminocaproic acid",
        "motility",
        "spermatozoa"
    ],
    "methods": null,
    "publication_date": "2022-01-13",
    "pubmed_id": "35021023",
    "results": "We observed a significant decrease in total sperm motility of the RMAX group compared to CG (",
    "title": "Radio-Protective effect of aminocaproic acid in human spermatozoa.",
    "xml": "<Element 'PubmedArticle' at 0x7885069c2a20>"
}