{
    "abstract": "To assess oocyte competence and embryo chromosomal constitution in phenotype-D PCOS women undergoing ICSI for PGT-A at the blastocyst stage.\nRetrospective study at a private IVF center. In the period 2013-2021, 58 na\u00efve phenotype-D PCOS women (i.e., oligomenorrhea, ovarian PCO-morphology, and absence of hyperandrogenism) underwent ICSI with ejaculated sperm for PGT-A. These cases were matched to 58 controls selected from 2211 na\u00efve women with idiopathic infertility planned for the same treatment in the same period. The matching variables were age (\u2248 36\u00a0years), BMI (\u2248 22), cumulus oocyte complexes (COCs) retrieved (\u2248 21-23), and sperm quality (\u2248 43-45% men with all sperm parameters\u2009>\u20095th percentile). The primary outcome was euploid blastocyst rate (EBR) per cohort of inseminated oocytes.\nMaturation rates per COCs and euploidy per biopsied blastocysts were similar. PCOS patients with phenotype-D showed higher fertilization per inseminated oocytes and higher blastulation per zygotes. This resulted into a higher EBR per inseminated oocytes and more euploid blastocysts available for transfer, although these differences adjusted for confounders were not significant. The live birth rate per first euploid transfers was comparable, so were all other outcomes considered.\nOocyte competence was not compromised in phenotype-D PCOS women, while good prognosis idiopathic infertile women might have unknown oocyte issues. In case of repeated failures after intrauterine insemination, a timely referral to IVF might represent an efficient strategy, in line with the \"one-and-done\" approach fulfilling a family planning perspective. Indeed, 22% of the phenotype-D PCOS women had 2 singleton LBs and 76% had surplus oocytes/euploid blastocysts after achieving\u2009\u2265\u20091 live birth.",
    "authors": [
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy. alberto.vaiarelli@gmail.com.",
            "firstname": "Alberto",
            "initials": "A",
            "lastname": "Vaiarelli"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.",
            "firstname": "Danilo",
            "initials": "D",
            "lastname": "Cimadomo"
        },
        {
            "affiliation": "Department of Surgical Sciences, Gynecologic Unit, University of Rome Tor Vergata, Rome, Italy.",
            "firstname": "Cecilia",
            "initials": "C",
            "lastname": "Rucci"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.",
            "firstname": "Federica",
            "initials": "F",
            "lastname": "Innocenti"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.",
            "firstname": "Marilena",
            "initials": "M",
            "lastname": "Taggi"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.\nDepartment of Surgical Sciences, Gynecologic Unit, University of Rome Tor Vergata, Rome, Italy.",
            "firstname": "Erika",
            "initials": "E",
            "lastname": "Pittana"
        },
        {
            "affiliation": "Department of Biology and Biotechnology 'Lazzaro Spallanzani', Laboratory of Biology and Biotechnology of Reproduction, University of Pavia, Pavia, Italy.",
            "firstname": "Giulia",
            "initials": "G",
            "lastname": "Fiorentino"
        },
        {
            "affiliation": "Department of Surgical Sciences, Gynecologic Unit, University of Rome Tor Vergata, Rome, Italy.",
            "firstname": "Pasquale",
            "initials": "P",
            "lastname": "Petrone"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.\nDepartment of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.",
            "firstname": "Daria Maria",
            "initials": "DM",
            "lastname": "Soscia"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.\nIVIRMA Global Research Alliance, B-Woman, Rome, Italy.\nDepartment of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.",
            "firstname": "Gemma",
            "initials": "G",
            "lastname": "Fabozzi"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.\nDepartment of Clinical and Molecular Medicine, University \"Sapienza\" of Rome, Rome, Italy.",
            "firstname": "Rossella",
            "initials": "R",
            "lastname": "Mazzilli"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.\nDipartimento Di Scienze Biomolecolari, Universit\u00e0 Di Urbino \"Carlo Bo\", Urbino, Italia.",
            "firstname": "Laura",
            "initials": "L",
            "lastname": "Rienzi"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Via G. De Notaris 2B, Rome, Italy.",
            "firstname": "Filippo Maria",
            "initials": "FM",
            "lastname": "Ubaldi"
        },
        {
            "affiliation": "Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.\nResearch Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, I.R.C.C.S. Matteo Foundation, Pavia, Italy.",
            "firstname": "Rossella Elena",
            "initials": "RE",
            "lastname": "Nappi"
        },
        {
            "affiliation": "IVIRMA Global Research Alliance, Livet, Turin, Italy.\nGynecology and Obstetrics 2U, Department of Surgical Sciences, S. Anna Hospital, University of Turin, Turin, Italy.",
            "firstname": "Gianluca",
            "initials": "G",
            "lastname": "Gennarelli"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
    "doi": "10.1007/s10815-024-03299-z",
    "journal": "Journal of assisted reproduction and genetics",
    "keywords": [
        "Blastocyst",
        "Euploid",
        "Oocyte competence",
        "PCOS phenotype-D",
        "PGT-A"
    ],
    "methods": null,
    "publication_date": "2024-11-04",
    "pubmed_id": "39495342\n32244180\n33439300\n38286488\n37580861\n30052961\n14688154\n29569621\n27233760\n27511809\n26261426\n27988256\n20639519\n33661465\n31916573\n18249393\n32500104\n10369209\n31403619\n25351780\n34798051\n30265329\n33608730\n28760517\n29117321\n21277789\n18081939\n34986863\n35039225\n8567853\n24355045\n28961822\n38502188\n23472949\n27566840\n29778554\n34223228\n35189133\n33703999\n19141487\n27137106\n27489079\n25972011\n15533360\n26158651\n29760297\n35701786\n32660710\n33377483\n20872066\n35856663\n22144224\n29260383\n36212560\n17433813\n37569402\n34912297\n30728173\n36920765\n38136954\n34368137\n34822691\n37192834\n37093443\n32532495\n27916206",
    "results": "Maturation rates per COCs and euploidy per biopsied blastocysts were similar. PCOS patients with phenotype-D showed higher fertilization per inseminated oocytes and higher blastulation per zygotes. This resulted into a higher EBR per inseminated oocytes and more euploid blastocysts available for transfer, although these differences adjusted for confounders were not significant. The live birth rate per first euploid transfers was comparable, so were all other outcomes considered.",
    "title": "ICSI and PGT-A in PCOS phenotype-D patients: a matched case-control study versus idiopathic infertile women.",
    "xml": "<Element 'PubmedArticle' at 0x788502662840>"
}