{
    "abstract": "To report our experience on homologous intrauterine insemination (IUI) with gonadotropin controlled ovarian stimulation (COS) cycles and to examine different variables which could predict IUI success.\nThis is a retrospective analysis of IUIs performed between January 1997 and December 2017. A total of 7359 COS IUI's procedures (2901 couples) were reviewed. Clinical pregnancy, live birth rate and age, body mass index (BMI), smoking habit, duration of infertility, sperm characteristics before and after treatment (total motile count, morphology, and vitality), day 3 FSH, total gonadotropin dose, and number of follicles were assessed by multivariate logistic regression analysis, and data were expressed as odds ratio (OR).\nThe mean female age at the time of COS was 35.10\u2009\u00b1\u20093.93\u00a0years. The most common single infertility diagnoses were unexplained infertility (53.55%), mild male factor (19.69%), and anovulation (10.95%). The total progressive motile sperm count (TPMC) was >\u20091\u2009\u00d7\u200910\nClinical pregnancy rate and live birth rates after COS-IUIs were significantly influenced by female age and FSH levels.\nClinical trial registration number: NCT03836118.",
    "authors": [
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Valentina",
            "initials": "V",
            "lastname": "Immediata"
        },
        {
            "affiliation": "Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Yale University, New Haven, CT, USA.",
            "firstname": "Pasquale",
            "initials": "P",
            "lastname": "Patrizio"
        },
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Maria Rosaria",
            "initials": "MR",
            "lastname": "Parisen Toldin"
        },
        {
            "affiliation": "Biostatistics Unit, Humanitas Cinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Emanuela",
            "initials": "E",
            "lastname": "Morenghi"
        },
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Camilla",
            "initials": "C",
            "lastname": "Ronchetti"
        },
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Federico",
            "initials": "F",
            "lastname": "Cirillo"
        },
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Annamaria",
            "initials": "A",
            "lastname": "Baggiani"
        },
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.",
            "firstname": "Elena",
            "initials": "E",
            "lastname": "Albani"
        },
        {
            "affiliation": "Department of Gynecology- Division of Gynecology and Reproductive Medicine- Humanitas Fertility Center, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy. paolo.levi_setti@humanitas.it.\nDepartment of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Yale University, New Haven, CT, USA. paolo.levi_setti@humanitas.it.",
            "firstname": "Paolo Emanuele",
            "initials": "PE",
            "lastname": "Levi-Setti"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1007/s10815-020-01752-3\n10.1093/humupd/dmx041\n10.1093/humupd/dmp003\n10.3399/bjgp14X676609\n10.1136/bmj.a716\n10.1016/j.fertnstert.2009.04.022\n10.1093/humrep/deq315\n10.1016/S0140-6736(17)32406-6\n10.1016/S0140-6736(17)33038-6\n10.1136/bmj.g7771\n10.1093/humrep/dev193\n10.1016/j.ejogrb.2014.05.003\n10.1016/j.fertnstert.2014.01.009\n10.1016/j.fertnstert.2009.09.009\n10.1016/j.fertnstert.2017.06.005\n10.1093/humupd/8.4.373\n10.1093/oxfordjournals.humrep.a019244\n10.1016/j.rbmo.2017.01.016\n10.1016/j.rbmo.2011.11.007\n10.1016/j.fertnstert.2008.09.058\n10.1016/S0015-0282(16)57650-X\n10.1093/humrep/12.7.1582\n10.1093/humrep/14.3.698\n10.1016/S0140-6736(99)04002-7\n10.1155/2017/3512784\n10.1016/j.fertnstert.2004.11.049\n10.1016/j.fertnstert.2004.01.042\n10.1016/j.fertnstert.2018.12.025\n10.1016/j.fertnstert.2019.02.026",
    "journal": "Journal of assisted reproduction and genetics",
    "keywords": [
        "Infertility",
        "Intrauterine Insemination",
        "Maternal Age",
        "Ovarian Reserve"
    ],
    "methods": null,
    "publication_date": "2020-03-28",
    "pubmed_id": "32215826\n7490200\n29479397\n29452361\n19240042\n24567574\n18687718\n19531445\n21127355\n29174128\n29174130\n25576320\n26269539\n24965998\n24534285\n19828144\n28760517\n12206471\n8671318\n28285953\n22197126\n18996517\n23926541\n7789569\n9262301\n10221698\n10615885\n24649556\n29387719\n15866592\n15374704\n30929730\n30929726\n17636632",
    "results": "The mean female age at the time of COS was 35.10\u2009\u00b1\u20093.93\u00a0years. The most common single infertility diagnoses were unexplained infertility (53.55%), mild male factor (19.69%), and anovulation (10.95%). The total progressive motile sperm count (TPMC) was >\u20091\u2009\u00d7\u200910",
    "title": "Twenty-one year experience with intrauterine inseminations after controlled ovarian stimulation with gonadotropins: maternal age is the only prognostic factor for success.",
    "xml": "<Element 'PubmedArticle' at 0x788504e987c0>"
}