{
    "abstract": "Mild-temperature photothermal therapy (mild PTT), utilizing photothermal agents to convert external light into mild heat (<45\u00a0\u00b0C), holds significant potential as a localized treatment modality to induce cellular thermal damage. This therapeutic strategy not only directly eliminates targeted cells but also induces immunogenic cell death (ICD), activating the immune response. However, the presence of heat shock proteins (HSPs) can significantly reduce the effectiveness of photothermal therapy. Therefore, it is crucial to inhibit HSP repair and minimize damage to surrounding normal cells in order to enhance the efficiency of low-temperature PTT. Additionally, carbon monoxide (CO) has been shown to suppress the upregulation of HSPs in cancer cells under heat treatment. Furthermore, the utilization of second near-infrared (NIR-II) fluorescence particles can improve the precision and suitability of PTT due to their increased penetration depth and novel imaging capabilities. In this study, we developed a NIR-light-activated CO release system using CO-loaded mesoporous organosilica nanoparticles (CO-MON) for enhancing the effectiveness of mild PTT by suppressing HSPs repair through selectively targeted CO delivery. Triiron dodecacarbonyl (Fe",
    "authors": [
        {
            "affiliation": "Shenzhen Key Laboratory of Viral Oncology, Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, PR China.",
            "firstname": "Shaoyan",
            "initials": "S",
            "lastname": "Gan"
        },
        {
            "affiliation": "Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, Guangdong 518116, PR China.",
            "firstname": "Xiuli",
            "initials": "X",
            "lastname": "Wen"
        },
        {
            "affiliation": "Shenzhen Key Laboratory of Viral Oncology, Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, PR China.",
            "firstname": "Li",
            "initials": "L",
            "lastname": "Li"
        },
        {
            "affiliation": "Shenzhen Key Laboratory of Viral Oncology, Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, PR China.",
            "firstname": "Keyi",
            "initials": "K",
            "lastname": "Ao"
        },
        {
            "affiliation": "Shenzhen Key Laboratory of Viral Oncology, Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, PR China.",
            "firstname": "Jiaqi",
            "initials": "J",
            "lastname": "Qin"
        },
        {
            "affiliation": "Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, Guangdong 518116, PR China. Electronic address: haoyi0320@szu.edu.cn.",
            "firstname": "Yi",
            "initials": "Y",
            "lastname": "Hao"
        },
        {
            "affiliation": "Shenzhen Key Laboratory of Viral Oncology, Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, PR China. Electronic address: myshow0504@smu.edu.cn.",
            "firstname": "Xia",
            "initials": "X",
            "lastname": "Guo"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025. Published by Elsevier Inc.",
    "doi": "10.1016/j.jcis.2025.137652",
    "journal": "Journal of colloid and interface science",
    "keywords": [
        "Carbon monoxide",
        "Heat shock proteins",
        "Immunogenic cell death",
        "Mild photothermal therapy",
        "Second near-infrared fluorescence"
    ],
    "methods": null,
    "publication_date": "2025-04-26",
    "pubmed_id": "40279848",
    "results": null,
    "title": "A cancer theranostic nanoplatform for second near-infrared fluorescence imaging-guided carbon monoxide-sensitized mild photothermal therapy with ICD induction.",
    "xml": "<Element 'PubmedArticle' at 0x788503f48450>"
}