{
    "abstract": "The purpose of this study was to describe morphological changes in lamina cribrosa (LC), prelaminar tissue thickness (PTT) and Bruch's membrane opening (BMO) in eyes affected by papilledema and correlate them with trans-LC-pressure difference (TLCD).\nThis was a prospective study, including twelve eyes newly diagnosed of papilledema. Eyes underwent scanning with Spectralis-OCT with enhanced depth imaging to compare BMO, anterior LC surface position (LC depth-LCD-) and PTT before and after oedema resolution. Correlation analysis between these parameters and TLCD was performed.\nTLCD inversely correlated with LCD at baseline and directly with LC reversal movement after lowering cerebrospinal fluid pressure (CSFP) (\u03c1\nLC position was significantly related to TLCD in papilledema. Eyes with higher TCLD showed significantly larger backward LC movement, BMO shrinking and RNFL thinning after lowering CSFP compared with eyes with lower TLCD, where LC movement occurred in the opposite direction.",
    "authors": [
        {
            "affiliation": "Department of Ophthalmology, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Viejo, km. 9.100, 28034, Madrid, Spain. jmontesinos86@hotmail.com.\nQvision, Department of Ophthalmology, Hospital Vithas Virgen del Mar, Almer\u00eda, Spain. jmontesinos86@hotmail.com.",
            "firstname": "Javier",
            "initials": "J",
            "lastname": "Garc\u00eda-Montesinos"
        },
        {
            "affiliation": "Department of Ophthalmology, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Viejo, km. 9.100, 28034, Madrid, Spain.",
            "firstname": "Francisco J",
            "initials": "FJ",
            "lastname": "Mu\u00f1oz-Negrete"
        },
        {
            "affiliation": "Department of Ophthalmology, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Viejo, km. 9.100, 28034, Madrid, Spain.",
            "firstname": "Victoria",
            "initials": "V",
            "lastname": "de Juan"
        },
        {
            "affiliation": "Department of Ophthalmology, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Viejo, km. 9.100, 28034, Madrid, Spain.",
            "firstname": "Gema",
            "initials": "G",
            "lastname": "Rebolleda"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1007/s00417-017-3661-6",
    "journal": "Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie",
    "keywords": [
        "Bruch\u2019s membrane opening",
        "Enhanced depth imaging",
        "Lamina cribrosa",
        "Papilledema",
        "Trans-laminar pressure difference"
    ],
    "methods": null,
    "publication_date": "2017-04-10",
    "pubmed_id": "28391369\n25115771\n25406288\n27966838\n23218823\n12455560\n9076222\n22464141\n27198638\n22807291\n27162227\n24232316\n21801338\n19011007\n26210868",
    "results": "TLCD inversely correlated with LCD at baseline and directly with LC reversal movement after lowering cerebrospinal fluid pressure (CSFP) (\u03c1",
    "title": "Relationship between lamina cribrosa displacement and trans-laminar pressure difference in papilledema.",
    "xml": "<Element 'PubmedArticle' at 0x788505d94ea0>"
}