{
    "abstract": "Acute lung injury (ALI), often complicated by bacterial infection, poses significant challenges in diagnosis and treatment. Nitric oxide (NO) plays a key role in the pathophysiology of ALI, making it an ideal biomarker for early detection. In this study, we developed a zwitterionic chromophore, ZW-N, designed as both a biomarker-activatable imaging probe and a therapeutic agent for ALI with bacterial infection. The chromophore ZW-N integrates quaternary ammonium groups for antimicrobial activity and zwitterionic sulfonate groups to enhance biocompatibility and water solubility. Built on a flexible propanyl linker that couples two heptamethine cyanine dyes, ZW-N enables biomarker-responsive dual-modal imaging ",
    "authors": [
        {
            "affiliation": "Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. mcfzeng@scut.edu.cn.",
            "firstname": "Zunpan",
            "initials": "Z",
            "lastname": "She"
        },
        {
            "affiliation": "Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. mcfzeng@scut.edu.cn.",
            "firstname": "Fang",
            "initials": "F",
            "lastname": "Zeng"
        },
        {
            "affiliation": "Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. mcfzeng@scut.edu.cn.",
            "firstname": "Shuizhu",
            "initials": "S",
            "lastname": "Wu"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1039/d5bm00419e",
    "journal": "Biomaterials science",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-04-17",
    "pubmed_id": "40243112",
    "results": null,
    "title": "A zwitterionic chromophore as both a biomarker-activatable optical imaging probe and a therapeutic agent for the detection and treatment of acute lung injury with bacterial infection.",
    "xml": "<Element 'PubmedArticle' at 0x788506f5a520>"
}