{
    "abstract": "Trophoblast cells undergo ferroptosis in pregnancy-related diseases. HMGB1 participates in pathological ferroptosis. However, whether lipopolysaccharide (LPS) -mediated HMGB1 expression induces the ferroptosis of trophoblast cells and further spontaneous abortion (SA) remains unknown.\nHMGB1 and ACSL4 expression were measured in villous tissues from 20 women with SA and 20 women with elective abortion. Human HTR-8/SVneo cells were treated with LPS to establish an in vitro abortion model. The hallmarks of ferroptosis including MDA, GSH, Fe\nThe levels of HMGB1 and ACSL4 in villous tissues from SA women were significantly higher than those in the normal control group. HMGB1 interacts with and stabilizes ACSL4 to promote the ferroptosis of trophoblast cells. Conversely, HMGB1 and/or ACSL4 inhibition attenuated LPS-induced trophoblast cells ferroptosis.\nAn HMGB1/ACSL4 axis is engaged in LPS-induced ferroptosis of trophoblast cells, and may be targeted to design treatments preventing SA.",
    "authors": [
        {
            "affiliation": "Department of Gynecology and Obstetrics, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China.\nDepartment of Gynecology and Obstetrics, Changzhou Maternity and Child Health Care Hospital, Changzhou, China.",
            "firstname": "Yishan",
            "initials": "Y",
            "lastname": "Dong"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China.",
            "firstname": "Yong",
            "initials": "Y",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, Changzhou Maternity and Child Health Care Hospital, Changzhou, China.",
            "firstname": "Wenjie",
            "initials": "W",
            "lastname": "Tang"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, Maoming Maternity and Child Health Care Hospital, Maoming, China.",
            "firstname": "Qin",
            "initials": "Q",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Gynecology and Obstetrics, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. kongchengcai12@163.com.\nDepartment of Gynecology and Obstetrics, Changzhou Maternity and Child Health Care Hospital, Changzhou, China. kongchengcai12@163.com.",
            "firstname": "Chengcai",
            "initials": "C",
            "lastname": "Kong"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1007/s43032-025-01817-7\n10.1016/j.placenta.2021.06.012\n10.1016/S0140-6736(06)69204-0\n10.1002/iid3.879\n10.1038/s41419-022-04579-1\n10.1126/sciadv.abm5500\n10.1007/s12020-021-02933-5\n10.1016/j.lfs.2024.122555\n10.1016/j.redox.2024.103073\n10.1016/j.jep.2023.117028\n10.1146/annurev-immunol-030409-101323\n10.1089/ars.2023.0236\n10.1186/s12931-022-01933-x\n10.1002/iid3.1124\n10.3389/fendo.2022.914030\n10.1016/j.intimp.2023.109757\n10.1016/j.envint.2023.108237\n10.1016/j.ecoenv.2022.114015\n10.3389/fcell.2023.1083838\n10.1016/j.intimp.2024.111792\n10.1016/j.phymed.2023.155186\n10.1016/j.freeradbiomed.2024.04.213\n10.1111/j.1365-2567.2007.02662.x\n10.1111/liv.15811\n10.1111/cbdd.14326\n10.1016/j.intimp.2023.110802\n10.1177/09603271231161606\n10.1126/sciadv.adk1200",
    "journal": "Reproductive sciences (Thousand Oaks, Calif.)",
    "keywords": [
        "Ferroptosis",
        "HMGB1/ACSL4 pathway",
        "Spontaneous abortion",
        "Trophoblast cell"
    ],
    "methods": null,
    "publication_date": "2025-02-25",
    "pubmed_id": "39994144\n34243116\n16905025\n37249279\n35165254\n35930635\n34859390\n38460811\n38335622\n37597678\n21219181\n36999916\n35093061\n38156383\n36465622\n36731154\n37802009\n36030684\n36968201\n38484667\n38387272\n38583680\n17617154\n38082504\n37604776\n37591122\n36905252\n38552012",
    "results": "The levels of HMGB1 and ACSL4 in villous tissues from SA women were significantly higher than those in the normal control group. HMGB1 interacts with and stabilizes ACSL4 to promote the ferroptosis of trophoblast cells. Conversely, HMGB1 and/or ACSL4 inhibition attenuated LPS-induced trophoblast cells ferroptosis.",
    "title": "Increased Trophoblast Cell Ferroptosis via HMGB1/ACSL4 Pathway Is Associated with Spontaneous Abortion.",
    "xml": "<Element 'PubmedArticle' at 0x788506f058a0>"
}