{
    "abstract": "During continuous-flow left ventricular assist device (CF-LVAD) support, hemodynamic shear stress causes a burden on aortic valve (AV) leaflets, leading to de novo aortic insufficiency (AI). This study investigated the influence of preoperative hemodynamic parameters on de novo AI in CF-LVAD recipients. We reviewed 125 patients who underwent CF-LVAD implantation without concomitant AV surgery between 2005 and 2018. De novo AI was defined as moderate or severe AI in those with none or trivial preoperative AI. During mean 30\u2009\u00b1\u200916\u00a0months of CF-LVAD support, de novo AI-free rate was 86% and 67% at 1 and 2\u00a0years, respectively. Multivariable analysis showed that higher right ventricular stroke work index (RVSWI) (hazard ratio, 1.12 /g/m",
    "authors": [
        {
            "affiliation": "Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Shusaku",
            "initials": "S",
            "lastname": "Maeda"
        },
        {
            "affiliation": "Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. k-toda@surg1.med.osaka-u.ac.jp.",
            "firstname": "Koichi",
            "initials": "K",
            "lastname": "Toda"
        },
        {
            "affiliation": "Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Kazuo",
            "initials": "K",
            "lastname": "Shimamura"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.",
            "firstname": "Kei",
            "initials": "K",
            "lastname": "Nakamoto"
        },
        {
            "affiliation": "Department of Biostatistics, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.",
            "firstname": "Masataka",
            "initials": "M",
            "lastname": "Igeta"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.",
            "firstname": "Yasushi",
            "initials": "Y",
            "lastname": "Sakata"
        },
        {
            "affiliation": "Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Yoshiki",
            "initials": "Y",
            "lastname": "Sawa"
        },
        {
            "affiliation": "Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Shigeru",
            "initials": "S",
            "lastname": "Miyagawa"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023. The Author(s).",
    "doi": "10.1007/s10047-023-01411-1\n10.1016/j.healun.2018.07.002\n10.1016/j.jchf.2018.07.012\n10.1016/j.athoracsur.2011.04.115\n10.1016/j.jtcvs.2015.09.128\n10.1016/j.healun.2010.11.007\n10.1016/j.healun.2006.10.004\n10.1016/j.healun.2014.11.008\n10.1016/j.athoracsur.2017.01.114\n10.1016/j.jtcvs.2015.05.034\n10.1016/j.jtcvs.2013.09.069\n10.1016/j.healun.2010.05.018\n10.1016/j.athoracsur.2012.09.020\n10.1016/j.healun.2014.06.008\n10.1161/CIRCHEARTFAILURE.113.000878\n10.1093/ejcts/ezv204\n10.1161/CIRCHEARTFAILURE.109.917765\n10.1016/j.jtcvs.2017.01.060\n10.1016/j.jtcvs.2019.01.070\n10.1111/aor.13671\n10.1093/eurheartj/11.suppl_I.1\n10.1016/j.healun.2015.10.022\n10.1097/MAT.0000000000000530\n10.1097/MAT.0b013e3182937a3a\n10.1016/j.jtcvs.2018.06.031\n10.1016/j.athoracsur.2012.03.021\n10.1016/j.jtcvs.2009.11.020\n10.1016/j.healun.2015.06.015\n10.1002/ejhf.733\n10.1016/j.jvs.2015.01.040",
    "journal": "Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs",
    "keywords": [
        "Aortic insufficiency",
        "Aortic valve opening",
        "Left ventricular assist device",
        "Right ventricular stroke work index",
        "Shear stress"
    ],
    "methods": null,
    "publication_date": "2023-07-20",
    "pubmed_id": "37468735\n30197211\n30384913\n21871279\n26699773\n21256765\n17178333\n25511747\n28483150\n26092505\n24345553\n25514870\n20619680\n23245444\n25108909\n24415682\n26084757\n20739615\n28676177\n30824341\n32080864\n2128742\n26612054\n28125466\n23820282\n30060931\n22571882\n20132950\n26267741\n28371221\n25752691",
    "results": null,
    "title": "Preoperative higher right ventricular stroke work index increases the risk of de novo aortic insufficiency after continuous-flow left ventricular assist device implantation.",
    "xml": "<Element 'PubmedArticle' at 0x78850477fec0>"
}