{
    "abstract": "We have performed a meta-analysis of studies reporting on Health-related quality of life (QoL) after endoscopic thyroidectomy (ETx) vs. open thyroidectomy (OTx).\nThe objective was to evaluate the QoL outcomes of ETx compared to OTx.\nEligibility criteria: Studies comparing ETx vs OTx INFORMATION SOURCES: PubMed, EMBASE, the Cochrane library, and online registers were searched for articles comparing QoL in ETx vs OTx.\nArticles were assessed for risk of bias using Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool.\nThe main summary measures using the random effects model were mean difference (MD).\nThree studies were included in the meta-analysis. \u00a0Two studies compared QoL between Transoral Endoscopic Thyroidectomy vs OTx and one compared Transaxillary Endoscopic Thyroidectomy vs OTx. There were no significant differences in the QoL outcomes using SF-36 scale. Pain scores assessed using the visual analogue scale (VAS) and overall satisfaction were also comparable between ETx and OTx.\nOur systematic review and meta-analysis indicate that QoL outcomes for ETx and OTx may be comparable based on the currently available evidence. The substantial heterogeneity across studies and the lack of adequately powered trials limit the generalizability of these findings. Future large-scale randomized controlled trials with robust QoL measures, such as ThyPRO-39, are needed to provide higher-quality evidence on the comparative effectiveness of ETx versus OTx.",
    "authors": [
        {
            "affiliation": "AIIMS, Nagpur, India.",
            "firstname": "Vishesh",
            "initials": "V",
            "lastname": "Agrawal"
        },
        {
            "affiliation": "Department of Surgery, Netaji Subhash Chandra Bose Medical Medical College, Jabalpur, 482003, MP, India. sky1508@gmail.com.",
            "firstname": "Sanjay Kumar",
            "initials": "SK",
            "lastname": "Yadav"
        },
        {
            "affiliation": "Department of Surgery, Netaji Subhash Chandra Bose Medical Medical College, Jabalpur, 482003, MP, India.",
            "firstname": "Pawan",
            "initials": "P",
            "lastname": "Agarwal"
        },
        {
            "affiliation": "Department of Surgery, Netaji Subhash Chandra Bose Medical Medical College, Jabalpur, 482003, MP, India.",
            "firstname": "Dhananjaya",
            "initials": "D",
            "lastname": "Sharma"
        },
        {
            "affiliation": "Department of Endocrine Surgery, RMLIMS, Lucknow, India.",
            "firstname": "Saroj Kanta",
            "initials": "SK",
            "lastname": "Mishra"
        }
    ],
    "conclusions": "Our systematic review and meta-analysis indicate that QoL outcomes for ETx and OTx may be comparable based on the currently available evidence. The substantial heterogeneity across studies and the lack of adequately powered trials limit the generalizability of these findings. Future large-scale randomized controlled trials with robust QoL measures, such as ThyPRO-39, are needed to provide higher-quality evidence on the comparative effectiveness of ETx versus OTx.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1007/s00423-025-03616-9",
    "journal": "Langenbeck's archives of surgery",
    "keywords": [
        "Endoscopic thyroidectomy",
        "Health related quality of life",
        "Meta-analysis",
        "Open thyroidectomy",
        "Systematic review"
    ],
    "methods": null,
    "publication_date": "2025-04-24",
    "pubmed_id": "40272595\n36755911\n36268522\n35470574\n32789681\n23678034\n22191388\n27733354\n31996201\n34082738\n25917054\n27445496\n38686757\n33043571\n36973129",
    "results": "Three studies were included in the meta-analysis. \u00a0Two studies compared QoL between Transoral Endoscopic Thyroidectomy vs OTx and one compared Transaxillary Endoscopic Thyroidectomy vs OTx. There were no significant differences in the QoL outcomes using SF-36 scale. Pain scores assessed using the visual analogue scale (VAS) and overall satisfaction were also comparable between ETx and OTx.",
    "title": "Quality of life after endoscopic vs. conventional open thyroidectomy: a systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788503bbb060>"
}