{
    "abstract": "The purpose of this study was to evaluate EpiColon, a novel human organotypic 3D colon microtissue prototype, developed to assess colonic drug disposition, with a particular focus on permeability ranking, and compare its performance to Caco-2 monolayers. EpiColon was characterized for barrier function using transepithelial electrical resistance (TEER), morphology via histology and immunohistochemistry, and functionality through drug transport studies measuring apparent permeability (P",
    "authors": [
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium; Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - box 921, 3000 Leuven, Belgium.",
            "firstname": "Pedro G M",
            "initials": "PGM",
            "lastname": "Canh\u00e3o"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.",
            "firstname": "Jan",
            "initials": "J",
            "lastname": "Snoeys"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.",
            "firstname": "Suzy",
            "initials": "S",
            "lastname": "Geerinckx"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.",
            "firstname": "Marjolein",
            "initials": "M",
            "lastname": "van Heerden"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.",
            "firstname": "An",
            "initials": "A",
            "lastname": "Van den Bergh"
        },
        {
            "affiliation": "MatTek Corporation, 200 Homer Avenue, Ashland, MA, USA.",
            "firstname": "Camden",
            "initials": "C",
            "lastname": "Holm"
        },
        {
            "affiliation": "MatTek In Vitro Life Science Laboratories, Bratislava, Slovak Republic.",
            "firstname": "Jan",
            "initials": "J",
            "lastname": "Markus"
        },
        {
            "affiliation": "MatTek Corporation, 200 Homer Avenue, Ashland, MA, USA.",
            "firstname": "Seyoum",
            "initials": "S",
            "lastname": "Ayehunie"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.",
            "firstname": "Mario",
            "initials": "M",
            "lastname": "Monshouwer"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Spring House, PA, USA.",
            "firstname": "Raymond",
            "initials": "R",
            "lastname": "Evers"
        },
        {
            "affiliation": "Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - box 921, 3000 Leuven, Belgium.",
            "firstname": "Patrick",
            "initials": "P",
            "lastname": "Augustijns"
        },
        {
            "affiliation": "Preclinical Sciences & Translational Safety, Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium. Electronic address: skourula@its.jnj.com.",
            "firstname": "Stephanie",
            "initials": "S",
            "lastname": "Kourula"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025. Published by Elsevier B.V.",
    "doi": "10.1016/j.ejps.2025.107025",
    "journal": "European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences",
    "keywords": [
        "Drug absorption",
        "Drug disposition",
        "Intestinal in vitro tools",
        "Intestinal permeability",
        "Organotypic colon microtissues",
        "Pharmacokinetics"
    ],
    "methods": null,
    "publication_date": "2025-01-27",
    "pubmed_id": "39864598",
    "results": null,
    "title": "Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition.",
    "xml": "<Element 'PubmedArticle' at 0x78850662e750>"
}