{
    "abstract": "Aim: To estimate pregnancy outcomes associated with endometriosis in Ukraine.\nMaterials and Methods: We performed the multicentre prospective cohort study during the period from January 1st, 2019 to December 31st, 2021. The study included pregnant women aged \u226518 years hospitalized in 17 hospitals from 15 regions of Ukraine. Logistic regression analysis provided odds ratios (OR) with 95% confidence intervals (CI).\nResults: Of the 27,558 women, 990 (3,6%) reported a diagnosis of endometriosis before pregnancy. In 990 deliveries, women with endometriosis had a higher risk of hypertension in pregnancy (OR 1.2, 95% CI 1.0-1.3), preeclampsia (OR 1.4, 95% CI 1.3-1.5), severe preeclampsia (OR 1.7, 95% CI 1.5-2.3), hemorrhage in pregnancy (OR 2.3, 95% CI 2.0-2.5), placental abruption (OR 2.0, 95% CI 1.7-2.3), placenta previa (OR 3.9, 95% CI 3.5-4.3), premature rupture of membranes (OR 1.7, 95% CI 1.5-1.8), and retained placenta (OR 3.1, 95% CI 1.4-6.6). The neonates had increased risks of preterm birth before 28 weeks (OR 3.1, 95% CI 2.7-3.6), birth before 34 weeks (OR 3.2, 95% CI 2.8-3.6), being small for gestational age (OR 1.5, 95% CI 1.4-1.6), being diagnosed with congenital malformations (OR 1.3, 95% CI 1.3-1.4), and neonatal death (OR 1.8, 95% CI 1.4-2.1).\nConclusions: Pregnant women with endometriosis are at elevated risk for serious and important adverse maternal, fetal and neonatal outcomes. The magnitude of these complications calls for more intensive antenatal care of pregnant women with endometriosis.",
    "authors": [
        {
            "affiliation": "SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE; INSTITUTE OF PEDIATRICS, OBSTETRICS AND GYNECOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.",
            "firstname": "Aidyn G",
            "initials": "AG",
            "lastname": "Salmanov"
        },
        {
            "affiliation": "ODESA NATIONAL MEDICAL UNIVERSITY, ODESA, UKRAINE.",
            "firstname": "Volodymyr V",
            "initials": "VV",
            "lastname": "Artyomenko"
        },
        {
            "affiliation": "SCHOOL OF MEDICINE OF V. N. KARAZIN KHARKIV NATIONAL UNIVERSITY, KHARKIV, UKRAINE.",
            "firstname": "Andrii O",
            "initials": "AO",
            "lastname": "Shchedrov"
        },
        {
            "affiliation": "KYIV CITY MATERNITY HOSPITAL NO3, KYIV, UKRAINE.",
            "firstname": "Andrii P",
            "initials": "AP",
            "lastname": "Prishchepa"
        },
        {
            "affiliation": "ODESA NATIONAL MEDICAL UNIVERSITY, ODESA, UKRAINE.",
            "firstname": "Svitlana M",
            "initials": "SM",
            "lastname": "Korniyenko"
        },
        {
            "affiliation": "BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.",
            "firstname": "Andriy I",
            "initials": "AI",
            "lastname": "Chubatyy"
        },
        {
            "affiliation": "BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.",
            "firstname": "Igor V",
            "initials": "IV",
            "lastname": "Maidannyk"
        },
        {
            "affiliation": "BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.",
            "firstname": "Olena O",
            "initials": "OO",
            "lastname": "Chorna"
        },
        {
            "affiliation": "NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.",
            "firstname": "Victor O",
            "initials": "VO",
            "lastname": "Rud"
        },
        {
            "affiliation": "MEDICAL CENTRE \"ASHERA\", KHARKIV, UKRAINE.",
            "firstname": "Vitalii S",
            "initials": "VS",
            "lastname": "Strakhovetskyi"
        },
        {
            "affiliation": "MEDICAL CENTRE \"ASHERA\", KHARKIV, UKRAINE.",
            "firstname": "Mykhailo V",
            "initials": "MV",
            "lastname": "Knyhin"
        },
        {
            "affiliation": "KYIV PERINATAL CENTER, KYIV, UKRAINE.",
            "firstname": "Anastasia S",
            "initials": "AS",
            "lastname": "Padchenko"
        }
    ],
    "conclusions": "Conclusions: Pregnant women with endometriosis are at elevated risk for serious and important adverse maternal, fetal and neonatal outcomes. The magnitude of these complications calls for more intensive antenatal care of pregnant women with endometriosis.",
    "copyrights": null,
    "doi": "10.36740/WLek202406101",
    "journal": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
    "keywords": [
        "Ukraine",
        "adverse outcomes",
        "endometriosis",
        "neonatal complications",
        "pregnancy complications",
        "reproductive health",
        "obstetrical complications"
    ],
    "methods": null,
    "publication_date": "2024-08-06",
    "pubmed_id": "39106368",
    "results": "Results: Of the 27,558 women, 990 (3,6%) reported a diagnosis of endometriosis before pregnancy. In 990 deliveries, women with endometriosis had a higher risk of hypertension in pregnancy (OR 1.2, 95% CI 1.0-1.3), preeclampsia (OR 1.4, 95% CI 1.3-1.5), severe preeclampsia (OR 1.7, 95% CI 1.5-2.3), hemorrhage in pregnancy (OR 2.3, 95% CI 2.0-2.5), placental abruption (OR 2.0, 95% CI 1.7-2.3), placenta previa (OR 3.9, 95% CI 3.5-4.3), premature rupture of membranes (OR 1.7, 95% CI 1.5-1.8), and retained placenta (OR 3.1, 95% CI 1.4-6.6). The neonates had increased risks of preterm birth before 28 weeks (OR 3.1, 95% CI 2.7-3.6), birth before 34 weeks (OR 3.2, 95% CI 2.8-3.6), being small for gestational age (OR 1.5, 95% CI 1.4-1.6), being diagnosed with congenital malformations (OR 1.3, 95% CI 1.3-1.4), and neonatal death (OR 1.8, 95% CI 1.4-2.1).",
    "title": "Adverse pregnancy outcomes associated with endometriosis in Ukraine: results a multicenter study.",
    "xml": "<Element 'PubmedArticle' at 0x788502d66160>"
}