{
    "abstract": "Female obesity has been conclusively associated with compromised fertility, adverse pregnancy outcomes and higher risks of obstetric and neonatal complications. However, it remains unclear whether the adverse outcomes observed in IVF treatments among women with obesity are primarily due to obesity itself or to underlying pathologies such as PCOS. Studies investigating the impact of overweight/obesity compared to normal weight in women with PCOS have yielded inconsistent findings.\nWe retrospectively analyzed 4083 women with PCOS undergoing the first IVF-ET cycle with antagonist protocol. Among them, 1755 were divided into the normal weight group (18.5 g/m\nWomen with overweight and obese had fewer numbers of oocytes retrieved (adjusted B: -0.82 [-1.17 to -0.47] and adjusted B: -1.86 [-2.26 to -1.46], respectively), numbers of 2PN (adjusted B: -0.52 [-0.78 to -0.26] and adjusted B: -1.86 [-2.26 to -1.46]), and numbers of good-quality embryos (adjusted B: -0.34 [-0.57 to -0.12] and adjusted B: -0.88 [-1.13 to -0.62]), compared to the women with normal weight. The live birth rate was 35.7%, 30.6% and 27.2% in the normal weight group, the overweight group and obese group, respectively (adjusted OR:0.76 [0.65 to 0.89]) for overweight verse normal weight, and adjusted OR:0.64 [0.53 to 0.76)] for obese verse normal weight). There were significant associations between higher BMI and adverse outcomes. We did not observe significant non-linear associations between BMI and these outcomes.\nOverweight or obese women with PCOS undergoing IVF-ET experienced lower numbers of oocytes and good quality embryos, reduced rates of live births, and higher rates of miscarriage compared to normal-weight women with PCOS.",
    "authors": [
        {
            "affiliation": "State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.\nBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China.\nCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.",
            "firstname": "Shuo",
            "initials": "S",
            "lastname": "Huang"
        },
        {
            "affiliation": "State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.\nBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China.\nCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.",
            "firstname": "Zheng",
            "initials": "Z",
            "lastname": "Wang"
        },
        {
            "affiliation": "State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.\nBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China.\nCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.",
            "firstname": "Rui",
            "initials": "R",
            "lastname": "Yang"
        },
        {
            "affiliation": "State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.\nBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China.\nCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.",
            "firstname": "Rong",
            "initials": "R",
            "lastname": "Li"
        },
        {
            "affiliation": "State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.\nKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.\nBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China.\nCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.",
            "firstname": "Jie",
            "initials": "J",
            "lastname": "Qiao"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Huang, Wang, Yang, Li and Qiao.",
    "doi": "10.3389/fendo.2025.1552561\n10.1210/clinem/dgad463\n10.1016/j.lanwpc.2022.100494\n10.3390/biomedicines7010005\n10.1093/molehr/gat065\n10.1093/humupd/dms030\n10.1186/s12958-018-0336-z\n10.1016/j.fertnstert.2017.01.017\n10.1093/humupd/dmz011\n10.1016/j.ejogrb.2022.01.019\n10.1016/j.fertnstert.2011.11.026\n10.1038/s41366-023-01430-1\n10.1017/S0967199420000830\n10.1016/j.ajog.2014.03.035\n10.1016/j.fertnstert.2007.10.077\n10.1016/j.ajog.2017.01.003\n10.1631/jzus.B1800113\n10.1093/humrep/deh098\n10.1016/j.bpobgyn.2014.10.014\n10.3389/fcell.2024.1461132\n10.1093/humrep/deq306\n10.1016/j.fertnstert.2011.07.1100\n10.1016/j.fertnstert.2015.11.008\n10.1093/humrep/deu276\n10.1016/j.fertnstert.2013.06.001\n10.1016/j.fertnstert.2019.08.009\n10.1001/jama.2013.6295\n10.1055/s-0035-1570027",
    "journal": "Frontiers in endocrinology",
    "keywords": [
        "IVF-ET",
        "PCOS",
        "infertility",
        "live birth",
        "obesity"
    ],
    "methods": null,
    "publication_date": "2025-04-11",
    "pubmed_id": "40213104\n37580314\n35669932\n30621143\n24026057\n22767467\n29523133\n28292619\n30941397\n35183001\n22192136\n38066333\n33455589\n24657792\n18191852\n28104402\n12015100\n14688154\n25619586\n39403129\n21071489\n21821244\n26627120\n25391239\n23830106\n31843094\n23757084\n26734917",
    "results": null,
    "title": "Embryological and pregnancy outcomes of IVF-ET in overweight/obese and normal-weight women with PCOS.",
    "xml": "<Element 'PubmedArticle' at 0x788503ede250>"
}