{
    "abstract": "The aim of this study was to describe different causes and consequences of fever during pregnancy in Western French Guiana and along the Maroni River.\nA retrospective single-center study including all patients with a history of documented fever \u2265 38\u00b0C during pregnancy at the West French Guiana Hospital for 9 years. Postpartum fever and nosocomial infections were excluded. We focused on medical history and on clinical and biological findings. Causes were characterized as confirmed or uncertain and then classified as preventable or non-preventable.\nA total of 940 pregnant women who experienced at least one episode of fever were included and compared to 23,811 deliveries who occurred during the same period without documented fever. Among them, 43.7% (411/940) were in labor. About 3.7% (35/940) of febrile pregnant women had at least two episodes of fever, while 0.3% (3/940) had a coinfection at the time of diagnosis, resulting in a total of 978 febrile episodes. Among them, causes remained unknown or uncertain in 7.6% (75/978) and 0.9% (9/978) of cases, respectively. Among confirmed causes of fever throughout pregnancy (n = 483), the most common known cause was arbovirus infection (146/483, 30.2%), followed by urinary tract infection (134/483, 27.7%), chickenpox (27/483, 5.6%), and gastrointestinal (14/483, 2.9%) and pulmonary infections (10/483, 2%). Mothers with fever had a higher risk of cesarean section (19.8% vs 15.5%, aOR 1.3 [95% CI 1.14-1.6], stillbirth (5.5% versus 1.9%, aOR 2.7 [95% CI 2-3.7]), and preterm delivery < 34 weeks of gestation (7.2% vs 4.7%, aOR 1.5 [95% CI 1.2-2].\nIn the Amazon region, causes of fever are diverse and often associated with epidemic waves, notably arboviruses. This must be considered when exploring possible causes of fever during pregnancy in these localities, including fetal anomalies and/or fetal loss. Physicians should consider the epidemiological context and avoid generalizations. Given the impact of emergent agents such as arboviruses on pregnancy, particular attention must be paid to the epidemiological context. This study can also help clinicians when managing fever in pregnant travelers or in their partner after having visited exposed areas. In this context, fetal abnormalities and adverse obstetric outcomes should be explored accordingly.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.\nINSERM CIC1424 Centre d'Investigation Clinique Antilles Guyane, Cayenne, French Guiana.",
            "firstname": "Najeh",
            "initials": "N",
            "lastname": "Hcini"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.",
            "firstname": "V\u00e9ronique",
            "initials": "V",
            "lastname": "Lambert"
        },
        {
            "affiliation": "Service Gyn\u00e9cologie Obst\u00e9trique, H\u00f4pital Louis Mourier, H\u00f4pitaux Universitaires Paris Nord Val de Seine, Assistance Publique: H\u00f4pitaux de Paris, Universit\u00e9 Paris Diderot, Colombes CEDEX, France.",
            "firstname": "Olivier",
            "initials": "O",
            "lastname": "Picone"
        },
        {
            "affiliation": "Department of Biology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.",
            "firstname": "Jean-Francois",
            "initials": "JF",
            "lastname": "Carod"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.",
            "firstname": "M\u00e9r\u00e9dith",
            "initials": "M",
            "lastname": "Mathieu"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.",
            "firstname": "Romane",
            "initials": "R",
            "lastname": "Cousin"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.",
            "firstname": "Ferroudja",
            "initials": "F",
            "lastname": "Akli"
        },
        {
            "affiliation": "Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.",
            "firstname": "Gabriel",
            "initials": "G",
            "lastname": "Carles"
        },
        {
            "affiliation": "Centre d'Investigation Clinique Antilles-Guyane, Epid\u00e9miologie Clinique, CIC INSERM 1424, DRISP, Centre hospitalier de Cayenne, Cayenne, French Guiana.",
            "firstname": "C\u00e9lia",
            "initials": "C",
            "lastname": "Basurko"
        },
        {
            "affiliation": "Ultrasound and Fetal Medicine, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.\nSchool of Health Sciences (HESAV), University of Applied Sciences and Arts Western Switzerland, Lausanne, Switzerland.",
            "firstname": "L\u00e9o",
            "initials": "L",
            "lastname": "Pomar"
        },
        {
            "affiliation": "INSERM CIC1424 Centre d'Investigation Clinique Antilles Guyane, Cayenne, French Guiana.\nDepartment of Infectious and Tropical Diseases Cayenne General Hospital French Guiana France.",
            "firstname": "Lo\u00efc",
            "initials": "L",
            "lastname": "Epelboin"
        },
        {
            "affiliation": "Centre d'Investigation Clinique Antilles-Guyane, Epid\u00e9miologie Clinique, CIC INSERM 1424, DRISP, Centre hospitalier de Cayenne, Cayenne, French Guiana.",
            "firstname": "Mathieu",
            "initials": "M",
            "lastname": "Nacher"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright: \u00a9 2023 Hcini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
    "doi": "10.1371/journal.pntd.0011721\n10.1016/j.accpm.2016.06.007\n10.1186/s12916-016-0695-2\n10.1371/journal.pone.0202005\n10.1136/bmj.k4431\n10.1056/NEJMoa1602412\n10.1038/s41591-019-0496-1\n10.1016/S2352-4642(17)30021-4\n10.1186/s13229-021-00464-4\n10.1542/peds.2013-3205\n10.1038/mp.2017.119\n10.1371/journal.pmed.1002373\n10.3201/eid1403.070906\n10.1128/JCM.36.5.1189-1192.1998\n10.2807/1560-7917.ES.2017.22.44.17-00102\n10.1002/uog.17404\n10.1080/01443615.2019.1647524\n10.1016/S2214-109X(17)30340-6\n10.1515/JPM.2003.006\n10.1016/0002-9378(75)90087-3\n10.1007/BF00218673\n10.1016/j.annepidem.2017.11.011\n10.1186/s12884-017-1585-0\n10.1016/j.ajog.2022.05.031\n10.1016/j.ajog.2017.02.022\n10.1016/j.ajog.2022.06.026\n10.1186/s12889-017-4557-4\n10.3390/v14122705\n10.1016/j.jogoh.2020.101899\n10.1016/S1473-3099(20)30432-1\n10.1056/NEJMra1213566\n10.1016/S0140-6736(09)61712-8",
    "journal": "PLoS neglected tropical diseases",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-10-24",
    "pubmed_id": "37874830\n27386764\n27645498\n30281605\n30381296\n26943629\n31285631\n30169203\n34537069\n24567014\n28607458\n28792500\n18325256\n9574674\n29113627\n30389543\n18006242\n28078779\n24440128\n32208419\n32648533\n28967610\n12661143\n37095766\n807107\n1783056\n29246500\n29221468\n35598690\n28216060\n36925412\n28716015\n32035728\n36560712\n32853830\n33068528\n24897084\n20223514",
    "results": "A total of 940 pregnant women who experienced at least one episode of fever were included and compared to 23,811 deliveries who occurred during the same period without documented fever. Among them, 43.7% (411/940) were in labor. About 3.7% (35/940) of febrile pregnant women had at least two episodes of fever, while 0.3% (3/940) had a coinfection at the time of diagnosis, resulting in a total of 978 febrile episodes. Among them, causes remained unknown or uncertain in 7.6% (75/978) and 0.9% (9/978) of cases, respectively. Among confirmed causes of fever throughout pregnancy (n = 483), the most common known cause was arbovirus infection (146/483, 30.2%), followed by urinary tract infection (134/483, 27.7%), chickenpox (27/483, 5.6%), and gastrointestinal (14/483, 2.9%) and pulmonary infections (10/483, 2%). Mothers with fever had a higher risk of cesarean section (19.8% vs 15.5%, aOR 1.3 [95% CI 1.14-1.6], stillbirth (5.5% versus 1.9%, aOR 2.7 [95% CI 2-3.7]), and preterm delivery < 34 weeks of gestation (7.2% vs 4.7%, aOR 1.5 [95% CI 1.2-2].",
    "title": "Causes and consequences of fever in Amazonian pregnant women: A large retrospective study from French Guiana.",
    "xml": "<Element 'PubmedArticle' at 0x788503319f30>"
}