{
    "abstract": "Left ventricular assist device (L-VAD) implantation is increasingly used in patients with heart failure (HF) and most patients also have an implantable cardioverter defibrillator (ICD). Limited data are available on the incidence of ICD therapies and complications in this special setting. The aim of this study was to analyze the real-world incidence and predictors of ICD therapies, complications and interactions between ICD and L-VAD.\nWe conducted a multicenter retrospective observational study in patients with advanced HF implanted with ICD and a continuous-flow L-VAD, followed-up in five advanced HF centers in Northern Italy.\nA total of 234 patients (89.7% male, median age 59, 48.3% with ischemic etiology) were enrolled. After a median follow-up of 21\u2009months, 66 patients (28.2%) experienced an appropriate ICD therapy, 22 patients (9.4%) an inappropriate ICD therapy, and 17 patients (7.3%) suffered from an interaction between ICD and L-VAD. The composite outcome of all ICD-related complications was reported in 41 patients (17.5%), and 121 (51.7%) experienced an L-VAD-related complication. At multivariable analysis, an active ventricular tachycardia (VT) zone and a prior ICD generator replacement were independent predictors of ICD therapies and of total ICD-related complications, respectively.\nReal-world patients with both L-VAD and ICD experience a high rate of ICD therapies and complications. Our findings suggest the importance of tailoring device programming in order to minimize the incidence of unnecessary ICD therapies, thus sparing the need for ICD generator replacement, a procedure associated to a high risk of complications.",
    "authors": [
        {
            "affiliation": "Arrhythmia and Electrophysiology Unit, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy.",
            "firstname": "Roberto",
            "initials": "R",
            "lastname": "Rordorf"
        },
        {
            "affiliation": "Arrhythmia and Electrophysiology Unit, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy.",
            "firstname": "Leonardo",
            "initials": "L",
            "lastname": "Pignalosa"
        },
        {
            "affiliation": "Arrhythmia and Electrophysiology Unit, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy.",
            "firstname": "Matteo",
            "initials": "M",
            "lastname": "Casula"
        },
        {
            "affiliation": "De Gasperis CardioCenter, Niguarda Hospital, Milan, Italy.",
            "firstname": "Enrico",
            "initials": "E",
            "lastname": "Perna"
        },
        {
            "affiliation": "De Gasperis CardioCenter, Niguarda Hospital, Milan, Italy.",
            "firstname": "Matteo",
            "initials": "M",
            "lastname": "Baroni"
        },
        {
            "affiliation": "De Gasperis CardioCenter, Niguarda Hospital, Milan, Italy.",
            "firstname": "Andrea",
            "initials": "A",
            "lastname": "Garascia"
        },
        {
            "affiliation": "Division of Cardiology, IRCCS Policlinico S. Matteo, Pavia, Italy.",
            "firstname": "Stefania",
            "initials": "S",
            "lastname": "Guida"
        },
        {
            "affiliation": "Division Cardiac Surgery, IRCCS Policlinico S. Matteo, Pavia, Italy.",
            "firstname": "Fabrizio",
            "initials": "F",
            "lastname": "Gazzoli"
        },
        {
            "affiliation": "Department of Perioperative Cardiology and Cardiovascular imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.",
            "firstname": "Daniela",
            "initials": "D",
            "lastname": "Pini"
        },
        {
            "affiliation": "Department of Perioperative Cardiology and Cardiovascular imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.\nDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "Cannata"
        },
        {
            "affiliation": "Department of Perioperative Cardiology and Cardiovascular imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.",
            "firstname": "Marta",
            "initials": "M",
            "lastname": "Pellegrino"
        },
        {
            "affiliation": "Division of Cardiology, Ospedale Giovanni XXIII, Bergamo, Italy.",
            "firstname": "Claudia",
            "initials": "C",
            "lastname": "Vittori"
        },
        {
            "affiliation": "Division of Cardiology, Ospedale Giovanni XXIII, Bergamo, Italy.",
            "firstname": "Paolo",
            "initials": "P",
            "lastname": "De Filippo"
        },
        {
            "affiliation": "Division of Cardiology, Ospedale Giovanni XXIII, Bergamo, Italy.",
            "firstname": "Giovanni",
            "initials": "G",
            "lastname": "Malanchini"
        },
        {
            "affiliation": "Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele University Hospital, Milan, Italy.",
            "firstname": "Pasquale",
            "initials": "P",
            "lastname": "Vergara"
        },
        {
            "affiliation": "Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele University Hospital, Milan, Italy.",
            "firstname": "Paolo",
            "initials": "P",
            "lastname": "Della Bella"
        },
        {
            "affiliation": "Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele University Hospital, Milan, Italy.",
            "firstname": "Simone",
            "initials": "S",
            "lastname": "Gulletta"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.",
    "doi": "10.1111/aor.14708",
    "journal": "Artificial organs",
    "keywords": [
        "ICD complications",
        "ICD programming",
        "end\u2010stage heart failure",
        "implantable cardioverter\u2010defibrillator (ICD)",
        "left ventricular assist device"
    ],
    "methods": null,
    "publication_date": "2024-01-12",
    "pubmed_id": "38213270",
    "results": "A total of 234 patients (89.7% male, median age 59, 48.3% with ischemic etiology) were enrolled. After a median follow-up of 21\u2009months, 66 patients (28.2%) experienced an appropriate ICD therapy, 22 patients (9.4%) an inappropriate ICD therapy, and 17 patients (7.3%) suffered from an interaction between ICD and L-VAD. The composite outcome of all ICD-related complications was reported in 41 patients (17.5%), and 121 (51.7%) experienced an L-VAD-related complication. At multivariable analysis, an active ventricular tachycardia (VT) zone and a prior ICD generator replacement were independent predictors of ICD therapies and of total ICD-related complications, respectively.",
    "title": "Real-world data of patients affected by advanced heart failure treated with implantable cardioverter defibrillator and left ventricular assist device: Results of a multicenter observational study.",
    "xml": "<Element 'PubmedArticle' at 0x788503dba520>"
}