{
    "abstract": "We present a swept-wavelength optical coherence tomography (OCT) system with a 19 MHz laser source and electronic phase-locking of the source, acquisition clock, and beam scanning mirrors. The laser is based on stretched-pulse active mode-locking using an electro-optic modulator. Beam scanning in the fast axis uses a resonant micro-electromechanical systems (MEMS) -based mirror at ~23.8 kHz. Acquisition is performed at 1.78 Gigasamples per second using an external fixed clock. Phase sensitive imaging without need for k-clocking, A-line triggers, or phase-calibration methods is demonstrated. The system was used to demonstrate inter-frame and inter-volume Doppler imaging in the mouse ear and brain at 4D acquisition rates of 1, 30, 60 and 100 volumes/sec (V-scans/s). Angiography based on inter-frame and inter-volume methods are presented. The platform offers extremely fast and phase-stable measurements that can be used in preclinical angiographic and Doppler investigations of perfusion dynamics.",
    "authors": [
        {
            "affiliation": "Harvard Medical School, Boston, Massachusetts 02115, USA.\nWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.\nIzmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340 Balcova, Izmir, Turkey.",
            "firstname": "Serhat",
            "initials": "S",
            "lastname": "Tozburun"
        },
        {
            "affiliation": "Harvard Medical School, Boston, Massachusetts 02115, USA.\nWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.",
            "firstname": "Cedric",
            "initials": "C",
            "lastname": "Blatter"
        },
        {
            "affiliation": "Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.\nHarvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA.",
            "firstname": "Meena",
            "initials": "M",
            "lastname": "Siddiqui"
        },
        {
            "affiliation": "Harvard Medical School, Boston, Massachusetts 02115, USA.\nEdwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.",
            "firstname": "Eelco F J",
            "initials": "EFJ",
            "lastname": "Meijer"
        },
        {
            "affiliation": "Harvard Medical School, Boston, Massachusetts 02115, USA.\nWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.\nHarvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA.",
            "firstname": "Benjamin J",
            "initials": "BJ",
            "lastname": "Vakoc"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1364/BOE.9.000952\n10.1126/science.1957169\n10.1038/nm0995-970\n10.1088/0034-4885/66/2/204\n10.1364/OE.11.002953\n10.1364/OE.11.000889\n10.1364/OE.11.002183\n10.1364/OL.39.006593\n10.1364/BOE.6.001340\n10.1117/1.JBO.20.3.030503\n10.1364/OE.18.014685\n10.1364/BOE.4.001890\n10.1364/BOE.5.002963\n10.1364/OL.33.001318\n10.1364/BOE.3.003067\n10.1117/12.911098\n10.1364/OE.11.003490\n10.1016/j.preteyeres.2014.03.004\n10.1364/OE.14.007821\n10.1364/OL.40.001779\n10.1364/OL.40.004771\n10.1364/OL.40.004791\n10.1117/1.JBO.21.3.036005\n10.1364/OPEX.13.010523\n10.1364/OPEX.13.005483\n10.1364/OE.19.020886\n10.1364/OE.22.003414\n10.1364/OPEX.13.003931\n10.1364/OE.15.012636\n10.1016/j.ophtha.2013.09.002\n10.1063/1.2357854",
    "journal": "Biomedical optics express",
    "keywords": [
        "(140.3600) Lasers, tunable",
        "(170.0110) Imaging systems",
        "(170.4500) Optical coherence tomography"
    ],
    "methods": null,
    "publication_date": "2018-03-16",
    "pubmed_id": "29541496\n1957169\n7585229\n19471415\n19461802\n19466106\n25490629\n25909017\n25803185\n20639955\n24156052\n25401010\n18552944\n23243560\n19471483\n24704352\n19529151\n25872072\n26469616\n26469621\n26968387\n19503267\n19498543\n21997098\n24663631\n20647356\n19495302\n19550532\n24156929",
    "results": null,
    "title": "Phase-stable Doppler OCT at 19 MHz using a stretched-pulse mode-locked laser.",
    "xml": "<Element 'PubmedArticle' at 0x78850523d030>"
}