{
    "abstract": "Infertility, adverse pregnancy outcomes and genital infections are global concerns. The reproductive tract microbiome appears to play a crucial role in the physiology of both the female and male reproductive tracts. Despite the presence of thousands of microbes in body fluids shared during unprotected sexual intercourse, they have traditionally been studied separately, with greater emphasis on the female (mostly vaginal) microbiome, and the interaction between these microbiomes in a sexually active couple has been overlooked. This review introduces the concept of the 'seminovaginal microbiome' - the collective microbiota of both partners, transferred and shared during sexual interaction. By synthesizing the existing body of next-generation sequencing-based literature, this review establishes the first holistic view of how these microbiomes interact, influence reproductive health and affect assisted reproductive technique outcomes, as well as the occurrence of microbe-associated diseases such as sexually transmitted infections, prostatitis, bacterial vaginosis and candidiasis. Additionally, the microbial interplay in homosexual couples and transgender individuals is discussed.",
    "authors": [
        {
            "affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain; Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain.",
            "firstname": "Nerea M",
            "initials": "NM",
            "lastname": "Molina"
        },
        {
            "affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain; Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain; Department of Physiology, Faculty of Veterinary Medicine, University of Murcia, Campus Mare Nostrum, Murcia, Spain. Electronic address: analuce.canha@um.es.",
            "firstname": "Analuce",
            "initials": "A",
            "lastname": "Canha-Gouveia"
        },
        {
            "affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain; Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain; Unidad de Reproducci\u00f3n, UGC de Obstetricia y Ginecolog\u00eda, Hospital Universitario Virgen de las Nieves, Granada, Spain.",
            "firstname": "Irene",
            "initials": "I",
            "lastname": "Leon\u00e9s-Ba\u00f1os"
        },
        {
            "affiliation": "Celvia CC AS, Tartu, Estonia; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Gynaecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.",
            "firstname": "Alberto",
            "initials": "A",
            "lastname": "Sola-Leyva"
        },
        {
            "affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain; Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain; Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Ja\u00e9n, Ja\u00e9n, Spain.",
            "firstname": "Eva",
            "initials": "E",
            "lastname": "Vargas"
        },
        {
            "affiliation": "Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain; Department of Obstetrics and Gynaecology, Virgen de las Nieves University Hospital, Granada, Spain.",
            "firstname": "Susana",
            "initials": "S",
            "lastname": "Ru\u00edz-Dur\u00e1n"
        },
        {
            "affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain; Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain.",
            "firstname": "Celia M",
            "initials": "CM",
            "lastname": "Tenorio"
        },
        {
            "affiliation": "Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain; Unidad de Reproducci\u00f3n, UGC de Obstetricia y Ginecolog\u00eda, Hospital Universitario Virgen de las Nieves, Granada, Spain.",
            "firstname": "Ana",
            "initials": "A",
            "lastname": "Clavero-Gilabert"
        },
        {
            "affiliation": "Celvia CC AS, Tartu, Estonia; Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.",
            "firstname": "Reet",
            "initials": "R",
            "lastname": "M\u00e4ndar"
        },
        {
            "affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain; Instituto de Investigaci\u00f3n Biosanitaria ibs. Granada, Granada, Spain; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Gynaecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address: signealtmae@ugr.es.",
            "firstname": "Signe",
            "initials": "S",
            "lastname": "Altm\u00e4e"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
    "doi": "10.1016/j.rbmo.2024.104707",
    "journal": "Reproductive biomedicine online",
    "keywords": [
        "16S rRNA gene",
        "Bacterial vaginosis",
        "Infertility",
        "Microbiota",
        "Prostatitis",
        "Sexually transmitted infections"
    ],
    "methods": null,
    "publication_date": "2025-04-03",
    "pubmed_id": "40174296",
    "results": null,
    "title": "The complementary seminovaginal microbiome in health and disease.",
    "xml": "<Element 'PubmedArticle' at 0x78850625b0b0>"
}