{
    "abstract": "Invasive stratified mucin-producing carcinoma (ISMC), an invasive form of stratified mucin-producing intraepithelial lesion (SMILE), is a newly named human papillomavirus (HPV) associated mucous adenocarcinoma of cervix. We aim to provide more clinical and pathological data for this uncommon disease.\nFifteen cases diagnosed as ISMC in our hospital were included, and their clinical and pathological data were retrospectively analyzed.\nThe patients' median age was 43\u00a0years (range, 30-54\u00a0years). The most prevalent symptom was abnormal vaginal bleeding. HPV test indicated high-risk HPV in all of our 15 cases. In addition, we observed several other architectural patterns of ISMC, including nest, gland-forming or lumen-forming, papillary with extravasated pools of mucin and solid. Immunohistochemically, all of our ISMC cases showed block-like expression of P16 and diffuse positive expression of CK8 and CK18, while P63, P40 and CK5/6 were spotted positive, or completely negative. Most importantly, ISMC has a relatively high lymph node metastasis rate of 33%.\nISMC is a special type of HPV-associated adenocarcinoma, displaying a wide morphologic spectrum combined with a unique immunohistochemical profile. Clinically, ISMC may have a higher rate of lymph node metastasis, which suggests more attention to postoperative follow-up.",
    "authors": [
        {
            "affiliation": "West China Second University Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Ting",
            "initials": "T",
            "lastname": "Lin"
        },
        {
            "affiliation": "West China Second University Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Wang"
        },
        {
            "affiliation": "West China Second University Hospital, Sichuan University, Chengdu, China.",
            "firstname": "Lian",
            "initials": "L",
            "lastname": "Xu"
        },
        {
            "affiliation": "West China Second University Hospital, Sichuan University, Chengdu, China. heyingpathology@163.com.",
            "firstname": "Ying",
            "initials": "Y",
            "lastname": "He"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
    "doi": "10.1007/s00404-022-06544-x\n10.1097/00000478-200010000-00012\n10.1097/pap.0000000000000266\n10.1097/pas.0000000000000543\n10.1016/j.humpath.2016.05.007\n10.1097/pas.0000000000000986\n10.1080/15384047.2019.1647054\n10.1007/s00432-019-02991-3\n10.1038/s41379-018-0123-6\n10.1097/pas.0000000000001480\n10.1002/ijgo.12611\n10.1097/PGP.0b013e31829952c6\n10.3969/j.issn.1007-8096.2020.06.004\n10.1007/bf02899201\n10.1097/pgp.0b013e31803c7c18\n10.3389/fcell.2014.00071\n10.1016/j.humpath.2012.03.023\n10.1007/s00405-014-3053-z\n10.1097/pas.0000000000001224",
    "journal": "Archives of gynecology and obstetrics",
    "keywords": [
        "Histological features",
        "Human papillomavirus (HPV)",
        "Immunohistochemistry",
        "Invasive stratified mucin-producing carcinoma (ISMC)",
        "Lymph node metastasis"
    ],
    "methods": null,
    "publication_date": "2022-04-09",
    "pubmed_id": "35394200\n11023104\n32482967\n26523540\n27237368\n29135516\n31362570\n31385027\n30258209\n32235154\n32922619\n17885499\n22809729\n24771140\n30720532",
    "results": "The patients' median age was 43\u00a0years (range, 30-54\u00a0years). The most prevalent symptom was abnormal vaginal bleeding. HPV test indicated high-risk HPV in all of our 15 cases. In addition, we observed several other architectural patterns of ISMC, including nest, gland-forming or lumen-forming, papillary with extravasated pools of mucin and solid. Immunohistochemically, all of our ISMC cases showed block-like expression of P16 and diffuse positive expression of CK8 and CK18, while P63, P40 and CK5/6 were spotted positive, or completely negative. Most importantly, ISMC has a relatively high lymph node metastasis rate of 33%.",
    "title": "Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.",
    "xml": "<Element 'PubmedArticle' at 0x788506079ad0>"
}