{
    "abstract": "The six-minute walk test (6MWT) is widely used to assess functional capacity and prognosis in patients with idiopathic pulmonary fibrosis (IPF). However, studies on oxygen saturation recovery after the 6MWT in patients with IPF are rare. In our study, we investigated the relationship between oxygen saturation recovery time and dyspnea, fatigue, quality of life, prognostic markers and pulmonary hypertension (PH).\nIn this cross-sectional study, IPF patients diagnosed according to current guidelines and followed up in our Interstitial Lung Disease Outpatient Clinic between 2021 and 2022 were included. Demographics, data from spirometry, diffusion capacity measurement, arterial blood gas analysis, transthoracic echocardiography and the 6MWT were recorded. The oxygen saturation recovery time, distance saturation product (DSP), gender-age-physiology (GAP) index and composite physiological index (CPI) scores were calculated. Dyspnea severity was assessed by the modified Medical Research Council (mMRC) and Dyspnoea-12 (D-12) scales, fatigue severity by the Multidimensional Fatigue Inventory (MFI-20) and quality of life by the St George's Respiratory Questionnaire (SGRQ).\nFifty IPF patients (34 men, 16 women, age: 66.8\u2009\u00b1\u20097.3 years) were included in the study. The mean FVC was 77.8\u2009\u00b1\u200919.3%, the DLCO was 52.9\u2009\u00b1\u200917.1%, the 6-minute walk distance (6MWD) was 385.7\u2009\u00b1\u200990.6\u00a0m, the GAP index was 3.5\u2009\u00b1\u20091.5, and the CPI was 43.7\u2009\u00b1\u200914.1. Oxygen saturation after the 6MWT reached pretest values at an average of 135.6\u2009\u00b1\u200973.5\u00a0s. The oxygen saturation recovery time was longer in patients with higher GAP index scores (Rs\u2009=\u20090.870, p\u2009<\u20090.001), CPI scores (Rs\u2009=\u20090.906, p\u2009<\u20090.001), desaturation (Rs\u2009=\u20090.801, p\u2009<\u20090.001), FVC%/DLCO% (Rs\u2009=\u20090.432, p\u2009=\u20090.002), sPAP (Rs\u2009=\u20090.492, p\u2009=\u20090.001), TRV (Rs\u2009=\u20090.504, p\u2009=\u20090.001), mMRC (Rs\u2009=\u20090.913, p\u2009<\u20090.001), MFI-20 (Rs\u2009=\u20090.944, p\u2009<\u20090.001), D-12 scale (Rs\u2009=\u20090.915, p\u2009<\u20090.001) and SGRQ scores (Rs\u2009=\u20090.927, p\u2009<\u20090.001); lower FVC (%) (Rs=-0.627, p\u2009<\u20090.001), DLCO (%) (Rs=-0.892, p\u2009<\u20090.001), PaO\nOur results showed that oxygen saturation recovery time is associated with dyspnea, fatigue, quality of life, increased risk of PH and prognostic markers in IPF. Therefore, we recommend continuous measurement of oxygen saturation after 6MWT until pretest values are reached.",
    "authors": [
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Merve Sinem",
            "initials": "MS",
            "lastname": "O\u011fuz"
        },
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Z\u00fcleyha",
            "initials": "Z",
            "lastname": "Bing\u00f6l"
        },
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Aylin",
            "initials": "A",
            "lastname": "P\u0131ht\u0131l\u0131"
        },
        {
            "affiliation": "Department of Cardiology, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Pelin",
            "initials": "P",
            "lastname": "Karaca \u00d6zer"
        },
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Melike",
            "initials": "M",
            "lastname": "Sar\u0131ta\u015f Arslan"
        },
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Zeki",
            "initials": "Z",
            "lastname": "K\u0131l\u0131\u00e7aslan"
        },
        {
            "affiliation": "Department of Cardiology, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Ahmet Kaya",
            "initials": "AK",
            "lastname": "Bilge"
        },
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey.",
            "firstname": "Esen",
            "initials": "E",
            "lastname": "K\u0131yan"
        },
        {
            "affiliation": "Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Fatih, Istanbul, Turkey. gulferokumus@yahoo.com.",
            "firstname": "G\u00fclfer",
            "initials": "G",
            "lastname": "Okumu\u015f"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s12890-024-03188-2\n10.1164/rccm.2009-040GL\n10.1016/S0140-6736(11)60052-4\n10.1164/rccm.201006-0894CI\n10.1111/resp.12683\n10.1016/j.rmed.2015.02.002\n10.1164/rccm.2111053\n10.1183/09031936.00106011\n10.7326/0003-4819-156-10-201205150-00004\n10.1186/s12931-016-0454-0\n10.1164/rccm.201007-1179OC\n10.1164/rccm.200604-488OC\n10.1164/rccm.200302-219OC\n10.1016/j.rmed.2006.02.004\n10.1183/13993003.01537-2014\n10.1007/s00408-011-9304-5\n10.1016/j.rmed.2012.07.013\n10.1111/j.1440-1843.2010.01877.x\n10.1111/j.1440-1843.2010.01877.x-52\n10.1186/s40248-018-0158-z\n10.1183/16000617.0087-2022\n10.1164/ajrccm.166.1.at1102\n10.1183/09031936.00150314\n10.1056/NEJMoa1002110\n10.1016/j.rmed.2009.09.006\n10.1159/000446607\n10.1378/chest.10-0693\n10.1016/j.rmr.2021.04.015\n10.1093/eurheartj/ehac237\n10.1183/09059180.00002512\n10.1186/s12931-019-1271-z\n10.1016/j.rmed.2008.07.022\n10.1164/rccm.200405-578OC\n10.1378/chest.129.3.746\n10.1183/13993003.00975-2015\n10.4187/respcare.06334\n10.1177/1479972311407355\n10.4187/respcare.02494\n10.1378/chest.128.4.2393\n10.1016/j.chest.2020.04.046\n10.1183/13993003.02316-2014\n10.1159/000327918\n10.1111/j.1440-1843.2010.01909.x\n10.1007/s11325-012-0716-0\n10.1164/rccm.201508-1546OC\n10.1016/j.cct.2020.106227\n10.1186/1477-7525-10-67",
    "journal": "BMC pulmonary medicine",
    "keywords": [
        "Idiopathic pulmonary fibrosis",
        "Oxygen saturation recovery time",
        "Pulmonary hypertension",
        "Six minute walk test"
    ],
    "methods": null,
    "publication_date": "2024-08-01",
    "pubmed_id": "39085811\n21471066\n21719092\n20935110\n26595062\n25727856\n12663338\n22241745\n22586007\n27756398\n21131468\n16825656\n12917227\n16545950\n26250495\n21660584\n20420729\n22902266\n20946337\n20946337\n30559965\n36002171\n12091180\n25359355\n20484178\n19815403\n27240427\n20595454\n33992493\n36017548\n23204124\n31915023\n18786822\n15640367\n16537877\n32023887\n27076586\n30377245\n21799083\n23942752\n16236900\n32387520\n26424523\n21677422\n21122030\n22562264\n25591141\n26938706\n33246099\n22694853",
    "results": "Fifty IPF patients (34 men, 16 women, age: 66.8\u2009\u00b1\u20097.3 years) were included in the study. The mean FVC was 77.8\u2009\u00b1\u200919.3%, the DLCO was 52.9\u2009\u00b1\u200917.1%, the 6-minute walk distance (6MWD) was 385.7\u2009\u00b1\u200990.6\u00a0m, the GAP index was 3.5\u2009\u00b1\u20091.5, and the CPI was 43.7\u2009\u00b1\u200914.1. Oxygen saturation after the 6MWT reached pretest values at an average of 135.6\u2009\u00b1\u200973.5\u00a0s. The oxygen saturation recovery time was longer in patients with higher GAP index scores (Rs\u2009=\u20090.870, p\u2009<\u20090.001), CPI scores (Rs\u2009=\u20090.906, p\u2009<\u20090.001), desaturation (Rs\u2009=\u20090.801, p\u2009<\u20090.001), FVC%/DLCO% (Rs\u2009=\u20090.432, p\u2009=\u20090.002), sPAP (Rs\u2009=\u20090.492, p\u2009=\u20090.001), TRV (Rs\u2009=\u20090.504, p\u2009=\u20090.001), mMRC (Rs\u2009=\u20090.913, p\u2009<\u20090.001), MFI-20 (Rs\u2009=\u20090.944, p\u2009<\u20090.001), D-12 scale (Rs\u2009=\u20090.915, p\u2009<\u20090.001) and SGRQ scores (Rs\u2009=\u20090.927, p\u2009<\u20090.001); lower FVC (%) (Rs=-0.627, p\u2009<\u20090.001), DLCO (%) (Rs=-0.892, p\u2009<\u20090.001), PaO",
    "title": "Oxygen saturation recovery after 6-minute walk test in patients with idiopathic pulmonary fibrosis.",
    "xml": "<Element 'PubmedArticle' at 0x788503cd4590>"
}