{
    "abstract": "The study objective was to evaluate changes in abdominal adipose tissue and ectopic fat during pregnancy and their associations with gestational weight gain (GWG) in women with overweight/obesity.\nThis study was a secondary analysis of a randomized controlled trial. Magnetic resonance scans were performed during gestational week (GW) 15, GW 32, and around birth to measure abdominal subcutaneous (SAT) and visceral (VAT) adipose tissues, liver fat, and muscle fat. Linear mixed models and multivariable linear regression analyses were utilized, adjusting for prepregnancy BMI, parity, and randomization.\nAmong 119 women, VAT and SAT decreased from GW 15 to GW 32 but rebounded at birth; final levels were lower than at GW 15. Liver fat and muscle fat did not change significantly. GWG was positively associated with changes in SAT but not with those in VAT, liver fat, or muscle fat.\nThis study demonstrates dynamic changes in abdominal fat depots during pregnancy in women with overweight/obesity. The observed reduction in VAT and SAT during pregnancy and the association of GWG with SAT suggest that weight gain during pregnancy may be less metabolically harmful than outside pregnancy. Future research should investigate the mechanisms and long-term effects on maternal and child health.",
    "authors": [
        {
            "affiliation": "Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "Christina Sonne",
            "initials": "CS",
            "lastname": "Mogensen"
        },
        {
            "affiliation": "Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "Faidon",
            "initials": "F",
            "lastname": "Magkos"
        },
        {
            "affiliation": "Department of Radiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark.",
            "firstname": "Elizaveta",
            "initials": "E",
            "lastname": "Chabanova"
        },
        {
            "affiliation": "Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "Christian",
            "initials": "C",
            "lastname": "M\u00f8lgaard"
        },
        {
            "affiliation": "Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.\nCentre for Childhood Health, Copenhagen, Denmark.\nDietetic and Clinical Nutrition Research Unit, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark.",
            "firstname": "Nina Rica Wium",
            "initials": "NRW",
            "lastname": "Geiker"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.",
    "doi": "10.1002/oby.24176",
    "journal": "Obesity (Silver Spring, Md.)",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-01-03",
    "pubmed_id": "39749416\n20669500\n3882502\n7020420\n2183610\n3542067\n31891231\n31301983\n21660078\n37755296\n23884194\n17167477\n32353068\n33073232\n34910089\n17284730\n26016860",
    "results": "Among 119 women, VAT and SAT decreased from GW 15 to GW 32 but rebounded at birth; final levels were lower than at GW 15. Liver fat and muscle fat did not change significantly. GWG was positively associated with changes in SAT but not with those in VAT, liver fat, or muscle fat.",
    "title": "Changes in abdominal adipose tissues and ectopic fat depots during pregnancy are dissociated from gestational weight gain.",
    "xml": "<Element 'PubmedArticle' at 0x788505757330>"
}