{
    "abstract": "Tissue engineering heavily relies on cell-seeded scaffolds to support the complex biological and mechanical requirements of a target organ. However, in addition to safety and efficacy, translation of tissue engineering technology will depend on manufacturability, affordability, and ease of adoption. Therefore, there is a need to develop scalable biomaterial scaffolds with sufficient bioactivity to eliminate the need for exogenous cell seeding. Herein, we describe implementation of an electroactive biodegradable elastomer for urinary bladder tissue engineering. To create an electrically conductive and mechanically robust scaffold to support bladder tissue regeneration, we develop a functionalization method wherein the hydrophobic conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) is polymerized in situ within a similarly hydrophobic citrate-based elastomer poly(octamethylene-citrate-co-octanol) (POCO) film. We demonstrate the efficacy of this scaffold for bladder augmentation in primarily female athymic rats, comparing PEDOT-POCO scaffolds to mesenchymal stromal cell-seeded POCO scaffolds. PEDOT-POCO recovers bladder function and anatomical structure comparably to the cell-seeded POCO scaffolds and significantly better than non-cell-seeded POCO scaffolds. This manuscript reports a functionalization method that confers electroactivity to a biodegradable elastic scaffold, facilitating the successful restoration of anatomical and physiological function of an organ.",
    "authors": [
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.",
            "firstname": "Rebecca L",
            "initials": "RL",
            "lastname": "Keate"
        },
        {
            "affiliation": "Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.\nStanley Manne Children's Research Institute, Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center, Chicago, IL, USA.",
            "firstname": "Matthew I",
            "initials": "MI",
            "lastname": "Bury"
        },
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.",
            "firstname": "Maria",
            "initials": "M",
            "lastname": "Mendez-Santos"
        },
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.",
            "firstname": "Andres",
            "initials": "A",
            "lastname": "Gerena"
        },
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.",
            "firstname": "Madeleine",
            "initials": "M",
            "lastname": "Goedegebuure"
        },
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Regenerative Nanomedicine, Northwestern University, Chicago, IL, USA.\nDepartment of Materials Science, Northwestern University, Evanston, IL, USA.\nQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.\nChemistry Life Processes Institute, Northwestern University, Evanston, IL, USA.\nInternational Institute for Nanotechnology, Evanston, IL, USA.",
            "firstname": "Jonathan",
            "initials": "J",
            "lastname": "Rivnay"
        },
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.\nDivision of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.\nStanley Manne Children's Research Institute, Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center, Chicago, IL, USA.\nCenter for Regenerative Nanomedicine, Northwestern University, Chicago, IL, USA.\nDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.",
            "firstname": "Arun K",
            "initials": "AK",
            "lastname": "Sharma"
        },
        {
            "affiliation": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.\nCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.\nQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.\nChemistry Life Processes Institute, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.\nInternational Institute for Nanotechnology, Evanston, IL, USA. g-ameer@northwestern.edu.\nDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. g-ameer@northwestern.edu.",
            "firstname": "Guillermo A",
            "initials": "GA",
            "lastname": "Ameer"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1038/s41467-024-55401-9",
    "journal": "Nature communications",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-01-03",
    "pubmed_id": "39746994\n37308586\n11334191\n14637100\n31469055\n32035282\n31214584\n16631879\n23895225\n26423725\n30707508\n32910197\n28533209\n29854930\n29580865\n29914213\n29434369\n24556448\n31704468\n31427743\n28865991\n28876908\n34445255\n18789820\n31976634\n22499946\n6127708\n4894870\n16871217\n29407177\n30600559\n35596668\n38043945\n37518771\n20488535\n38344009\n11523031\n27347559\n21784176\n16919720\n29632879\n37327023\n32122857\n23431178\n14662404\n26918151\n24816362\n37628719\n15901280\n28719819\n35060797\n22350082\n33504876\n30553012\n33336114\n35415280\n34323358\n22713548\n36094424\n30930534\n30013027\n30983315\n33751880\n29032331\n32441388\n30336245\n29684268\n36635590\n25688036\n32864811\n26407651\n8011335\n16685600\n16581961\n28406893\n16404714\n25145852\n26398705",
    "results": null,
    "title": "Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration.",
    "xml": "<Element 'PubmedArticle' at 0x7885049484f0>"
}