{
    "abstract": "Liver injury is a frequent complication in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS). The Model for End-Stage Liver Disease incorporating albumin (MELD-albumin) quantifies liver injury. This study assesses the association between MELD-albumin score and all-cause mortality among patients with AMICS.\nFrom a retrospective cohort of 1716 consecutive AMICS patients admitted between 2010 and 2017, we included patients who survived until day 3 and had complete laboratory data available (N=717). MELD-albumin was calculated using 0 to 72-hour peak s-bilirubin and s-creatinine values and the lowest s-albumin value. Patients were stratified into tertiles low, intermediate, and high MELD-albumin. The primary outcome was all-cause mortality with a follow-up of up to 14 years.Patients in the high score group were more often female, had lower left ventricular ejection fraction, higher lactate levels, and less suffered out-of-hospital cardiac arrest. The high score group had a significantly higher all-cause mortality rate than the intermediate and low score group at 30 days (49 vs. 35 vs. 26%, p<0.001) and 10 years for 30-day survivors (58 vs. 46 vs. 37%, p<0.001). Adjusted hazard ratios for mortality in the high score group were 2.02 at 30 days (95% CI: 1.49-2.74, p<0.001) and 1.86 at 10 years (95% CI: 1.18-2.92, p<0.001). The MELD-albumin score demonstrated an area under the receiver operating curve of 0.63 (95% CI: 0.59-0.67) for predicting 30-day mortality.\nLiver injury, quantified as MELD-albumin score, was significantly associated with short- and long-term all-cause mortality among AMICS patients.",
    "authors": [
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Zakaria",
            "initials": "Z",
            "lastname": "Alaoui-Ismaili"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Joakim",
            "initials": "J",
            "lastname": "Bo Kunkel"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Anika",
            "initials": "A",
            "lastname": "Klein"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Jakob",
            "initials": "J",
            "lastname": "Josiassen"
        },
        {
            "affiliation": "Department of Cardiology, Odense University Hospital, Odense, Denmark.",
            "firstname": "Ole",
            "initials": "O",
            "lastname": "Kristian Lerche Helgestad"
        },
        {
            "affiliation": "Department of Cardiology, Odense University Hospital, Odense, Denmark.",
            "firstname": "Karoline",
            "initials": "K",
            "lastname": "Korsholm Jeppesen"
        },
        {
            "affiliation": "Department of Cardiology, Odense University Hospital, Odense, Denmark.",
            "firstname": "Henrik",
            "initials": "H",
            "lastname": "Schmidt"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Lene",
            "initials": "L",
            "lastname": "Holmvang"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Peter",
            "initials": "P",
            "lastname": "Laursen Graversen"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Emil",
            "initials": "E",
            "lastname": "Fosb\u00f8l"
        },
        {
            "affiliation": "Department of Cardiothoracic Anaesthesia, Odense University Hospital, Odense, Denmark.",
            "firstname": "Hanne",
            "initials": "H",
            "lastname": "Berg Ravn"
        },
        {
            "affiliation": "Department of Cardiology, Odense University Hospital, Odense, Denmark.",
            "firstname": "Lisette",
            "initials": "L",
            "lastname": "Okkels Jensen"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.\nDepartment of Cardiology, Odense University Hospital, Odense, Denmark.",
            "firstname": "Jacob",
            "initials": "J",
            "lastname": "Eifer M\u00f8ller"
        },
        {
            "affiliation": "Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "Christian",
            "initials": "C",
            "lastname": "Hassager"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site\u2014for further information please contact journals.permissions@oup.com.",
    "doi": "10.1093/ehjacc/zuaf063",
    "journal": "European heart journal. Acute cardiovascular care",
    "keywords": [
        "Acute Myocardial Infarction",
        "Albumin",
        "Cardiogenic shock",
        "Liver injury",
        "Model for End-stage Liver Disease",
        "Mortality"
    ],
    "methods": null,
    "publication_date": "2025-04-23",
    "pubmed_id": "40265664",
    "results": null,
    "title": "Model for End-Stage Liver Disease incorporating albumin score is associated with short- and long-term all-cause mortality in patients with acute myocardial infarction complicated by cardiogenic shock.",
    "xml": "<Element 'PubmedArticle' at 0x7885049fd440>"
}