{
    "abstract": "Apricot kernels containing amygdalin (AMG) as the major cyanogenic glycoside are potentially useful as a complementary therapy for the management of several ailments including cancer. Nevertheless, little is known regarding the toxic and therapeutic doses of AMG, particularly in terms of male reproduction. Hence, this study evaluates selected qualitative characteristics of rabbit testicular tissue following \nThe rabbits were randomly divided into five groups (Control, P1, P2, P3, P4). The Control received no AMG/apricot kernels while the experimental groups P1 and P2 received a daily intramuscular injection of amygdalin at a dose of 0.6 and 3.0 mg/kg of body weight (b.w.) for 28 days, respectively. P3 and P4 received a daily dose of 60 and 300 mg/kg b.w. of crushed apricot kernels mixed with feed for 28 days, respectively. Changes to the testicular structure were quantified morphometrically, while tissue lysates were subjected to the evaluation of reactive oxygen species (ROS) production, total antioxidant capacity, activities of antioxidant enzymes, and glutathione concentration. The extent of damage to the proteins and lipids was quantified as well. Levels of selected cytokines were determined by the enzyme-linked immunosorbent assay while a luminometric approach was used to assess the activity of caspases.\nRabbits treated with 3.0 mg/kg b.w. AMG presented a significantly increased protein oxidation (\nApricot kernels did not induce toxicity in the testicular tissues of male rabbits, unlike pure AMG, which had a negative effect on male reproductive structures carried out through oxidative, inflammatory, and pro-apoptotic mechanisms.",
    "authors": [
        {
            "affiliation": "Institute of Biotechnology, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.",
            "firstname": "Eva",
            "initials": "E",
            "lastname": "Tvrd\u00e1"
        },
        {
            "affiliation": "AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.",
            "firstname": "Michal",
            "initials": "M",
            "lastname": "\u010eura\u010dka"
        },
        {
            "affiliation": "Institute of Applied Biology, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.",
            "firstname": "Marek",
            "initials": "M",
            "lastname": "Halen\u00e1r"
        },
        {
            "affiliation": "Animal Production Research Centre Nitra, National Agricultural and Food Center, 951 41 Lu\u017eianky, Slovakia.",
            "firstname": "Juraj",
            "initials": "J",
            "lastname": "Pivko"
        },
        {
            "affiliation": "Institute of Applied Biology, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.",
            "firstname": "Eduard",
            "initials": "E",
            "lastname": "Koles\u00e1r"
        },
        {
            "affiliation": "Animal Production Research Centre Nitra, National Agricultural and Food Center, 951 41 Lu\u017eianky, Slovakia.",
            "firstname": "\u013dubica",
            "initials": "\u013d",
            "lastname": "Chrastinov\u00e1"
        },
        {
            "affiliation": "Animal Production Research Centre Nitra, National Agricultural and Food Center, 951 41 Lu\u017eianky, Slovakia.",
            "firstname": "\u013dubom\u00edr",
            "initials": "\u013d",
            "lastname": "Ondru\u0161ka"
        },
        {
            "affiliation": "Animal Production Research Centre Nitra, National Agricultural and Food Center, 951 41 Lu\u017eianky, Slovakia.",
            "firstname": "Rastislav",
            "initials": "R",
            "lastname": "Jur\u010d\u00edk"
        },
        {
            "affiliation": "AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.\nInstitute of Applied Biology, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.",
            "firstname": "Adriana",
            "initials": "A",
            "lastname": "Koles\u00e1rov\u00e1"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Author(s). Published by IMR Press.",
    "doi": "10.31083/j.fbl2906235",
    "journal": "Frontiers in bioscience (Landmark edition)",
    "keywords": [
        "amygdalin",
        "apricot kernels",
        "caspases",
        "histology",
        "inflammation",
        "oxidative stress",
        "rabbits",
        "testes"
    ],
    "methods": null,
    "publication_date": "2024-06-28",
    "pubmed_id": "38940029",
    "results": "Rabbits treated with 3.0 mg/kg b.w. AMG presented a significantly increased protein oxidation (",
    "title": "The Effects of Apricot Kernels and Pure Amygdalin on the Structural, Oxidative, and Inflammatory Characteristics of Rabbit Testicular Tissue.",
    "xml": "<Element 'PubmedArticle' at 0x78850403fbf0>"
}