{
    "abstract": "To explore the clinical significance of albumin(Alb) to the derive(d) neutrophil-to-lymphocyte ratio(NLR) in patients with esophageal squamous cell carcinoma (ESCC) aged 60 years and above.\n328 patients with ESCC at Shanxi Province Cancer Hospital were enrolled in this study. The dNLR was calculated using the following formula: neutrophil count / (leukocyte count\u2009-\u2009neutrophil count). Alb to dNLR or the Alb/dNLR ratio was calculated by dividing the Alb level by the dNLR level.Receiver operating characteristic (ROC) curve analysis was used to determine the cutoff values for Alb to dNLR.\nROC analysis displayed that the cut-off value of Alb to dNLR was defined to be 20.28 U/mL. The AlbtodNLR was not related to clinical features but to survival status (all P\u2009>\u20090.05). ESCC patients aged 60 years and above with a high AlbtodNLR had better survival than those with a low Alb-to-dNLR (P\u2009=\u20090.005). Similar results were observed in male patients with ESCC (P\u2009=\u20090.001), subgroups with upper and middle locations (P\u2009=\u20090.013 and 0.017), tobacco consumption (P\u2009=\u20090.004), non-drinkers (P\u2009=\u20090.029), well and moderate differentiation (P\u2009=\u20090.014), lymph node involvement (P\u2009<\u20090.001), advanced T stage (P\u2009=\u20090.014), and advanced TNM staging (P\u2009=\u20090.001). Univariate Cox regression analysis indicated that tumor grade, T staging, lymph node metastasis(LNM), TNM staging, and Alb to dNLR ratio were predictors of death from ESCC. In a multivariate Cox regression analysis, a lower AlbtodNLR levels, and advanced T stage were associated with an increased risk of ESCC-related death.\nCollectively, Alb to dNLR were inversely associated with outcome and were regarded as an independent influencing factor for ESCC subpopulation aged 60 years and above.",
    "authors": [
        {
            "affiliation": "Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.",
            "firstname": "Xiaoqin",
            "initials": "X",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.",
            "firstname": "Ting",
            "initials": "T",
            "lastname": "Sun"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.",
            "firstname": "Xiaofang",
            "initials": "X",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.",
            "firstname": "Weigang",
            "initials": "W",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.",
            "firstname": "Yanfen",
            "initials": "Y",
            "lastname": "Ji"
        },
        {
            "affiliation": "Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China. sxszlyyzjh@163.com.",
            "firstname": "Jiexian",
            "initials": "J",
            "lastname": "Jing"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s12885-025-14010-5",
    "journal": "BMC cancer",
    "keywords": [
        "Albumin",
        "Derived neutrophil-to-lymphocyte ratio",
        "Esophageal squamous cell carcinoma",
        "Prognosis"
    ],
    "methods": null,
    "publication_date": "2025-04-10",
    "pubmed_id": "40205371\n30207593\n36644140\n35117757\n31289589\n30070689\n36338698\n35165274\n38566981\n33814930\n35452997\n30305803\n34807322\n35622180\n37932676\n38041687\n33464731\n28842111\n31737304\n24751582\n22039411\n28554754\n31674067\n33442408\n35031957",
    "results": "ROC analysis displayed that the cut-off value of Alb to dNLR was defined to be 20.28 U/mL. The AlbtodNLR was not related to clinical features but to survival status (all P\u2009>\u20090.05). ESCC patients aged 60 years and above with a high AlbtodNLR had better survival than those with a low Alb-to-dNLR (P\u2009=\u20090.005). Similar results were observed in male patients with ESCC (P\u2009=\u20090.001), subgroups with upper and middle locations (P\u2009=\u20090.013 and 0.017), tobacco consumption (P\u2009=\u20090.004), non-drinkers (P\u2009=\u20090.029), well and moderate differentiation (P\u2009=\u20090.014), lymph node involvement (P\u2009<\u20090.001), advanced T stage (P\u2009=\u20090.014), and advanced TNM staging (P\u2009=\u20090.001). Univariate Cox regression analysis indicated that tumor grade, T staging, lymph node metastasis(LNM), TNM staging, and Alb to dNLR ratio were predictors of death from ESCC. In a multivariate Cox regression analysis, a lower AlbtodNLR levels, and advanced T stage were associated with an increased risk of ESCC-related death.",
    "title": "The predicting role of albumin to derived neutrophil-to-lymphocyte ratio for the prognosis of esophageal squamous cell carcinoma patients aged 60 years and above.",
    "xml": "<Element 'PubmedArticle' at 0x78850319ee80>"
}