{
    "abstract": "Ischemic stroke (IS) as a detrimental neurological disease is accompanied by oxidative-stress-induced injury, concurrent inflammatory response, overactivated brain immune microenvironment, and disruption of the blood-brain barrier (BBB). This cascade of events ultimately leads to neuronal death and significantly impairs the recovery of neurological function. In this study, we presented extracellular vesicles derived from the gut probiotic ",
    "authors": [
        {
            "affiliation": "School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Mengdi",
            "initials": "M",
            "lastname": "Sun"
        },
        {
            "affiliation": "Institution of Life Science, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Jinghan",
            "initials": "J",
            "lastname": "Ma"
        },
        {
            "affiliation": "School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Ge",
            "initials": "G",
            "lastname": "Zhang"
        },
        {
            "affiliation": "School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Mingzhu",
            "initials": "M",
            "lastname": "Song"
        },
        {
            "affiliation": "School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Ruizhen",
            "initials": "R",
            "lastname": "Lv"
        },
        {
            "affiliation": "Institution of Life Science, Jinzhou Medical University, Jinzhou 121000, PR China.\nKey Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou 121000, PR China.\nCollaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Jia",
            "initials": "J",
            "lastname": "Liang"
        },
        {
            "affiliation": "School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Yijie",
            "initials": "Y",
            "lastname": "Shi"
        },
        {
            "affiliation": "School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.\nKey Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou 121000, PR China.\nCollaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou 121000, PR China.",
            "firstname": "Liang",
            "initials": "L",
            "lastname": "Zhao"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1021/acsnano.4c16161",
    "journal": "ACS nano",
    "keywords": [
        "Lactobacillus reuteri",
        "blood-brain barrier",
        "extracellular vesicles",
        "ischemic stroke",
        "microglial polarization",
        "reactive oxygen species"
    ],
    "methods": null,
    "publication_date": "2025-04-18",
    "pubmed_id": "40249658",
    "results": null,
    "title": "Brain Targeting Bacterial Extracellular Vesicles Enhance Ischemic Stroke Therapy via Efficient ROS Elimination and Suppression of Immune Infiltration.",
    "xml": "<Element 'PubmedArticle' at 0x7885039f9b70>"
}