{
    "abstract": "Glycosaminoglycans (GAGs) are vital polysaccharides that constitute key elements of the extracellular matrix (ECM), particularly within chondroitin sulfate proteoglycans (CSPGs). GAGs exhibit a dual role in neural tissue: they facilitate synaptic plasticity and cellular adhesion, essential for neural function, while posing as barriers to axonal regeneration following injury. Through interactions with diverse proteins, including enzymes, cytokines, and growth factors, GAGs critically influence neural development, repair, and homeostasis. Recent advancements have underscored the therapeutic potential of modulating GAG synthesis, degradation, and receptor interactions to address neuroinflammation, promote neural repair, and counteract inhibitory signals in the injured CNS. Furthermore, combining GAG-targeted therapies with complementary approaches, such as gene therapy or nanoparticle-based delivery systems, holds promise for achieving synergistic effects and enhancing treatment outcomes. This mini-review explores the multifaceted roles of GAGs in neural physiology and pathology, highlighting their emerging potential as therapeutic targets for neurological disorders.",
    "authors": [
        {
            "affiliation": "State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. Electronic address: tali@bs.qau.edu.pk.",
            "firstname": "Tahir",
            "initials": "T",
            "lastname": "Ali"
        },
        {
            "affiliation": "Signal Transduction lab, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan. Electronic address: Irambch@qau.edu.pk.",
            "firstname": "Iram",
            "initials": "I",
            "lastname": "Murtaza"
        },
        {
            "affiliation": "State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. Electronic address: hongling.guo@pku.edu.cn.",
            "firstname": "Hongling",
            "initials": "H",
            "lastname": "Guo"
        },
        {
            "affiliation": "State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. Electronic address: lisp@pku.edu.cn.",
            "firstname": "Shupeng",
            "initials": "S",
            "lastname": "Li"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.bbrc.2025.151861",
    "journal": "Biochemical and biophysical research communications",
    "keywords": [
        "CSPG",
        "ECM",
        "GAG",
        "Neurological diseases"
    ],
    "methods": null,
    "publication_date": "2025-04-26",
    "pubmed_id": "40279798",
    "results": null,
    "title": "Glycosaminoglycans: Mechanisms and therapeutic potential in neurological diseases: A mini-review.",
    "xml": "<Element 'PubmedArticle' at 0x7885020f8a40>"
}