{
    "abstract": "Clinical presentations of left ventricular non-compaction (LVNC) range from asymptomatic cases to ventricular tachyarrhythmia (VT), heart failure (HF), and cerebrovascular accidents (CVA). In this multicenter study, we explored the associations between clinical and imaging characteristics and outcomes of LVNC patients and validated the predictive value of myocardial thinning identified on cardiac magnetic resonance imaging (CMR) as previously described.\n214 adult patients (54% male, mean age 41\u00b116 years) meeting the imaging criteria for LVNC were identified. Myocardial thinning was defined as a 50% or greater diameter reduction of the compacted myocardium compared to a contiguous segment on CMR. The primary endpoint was the occurrence of a major adverse cardiovascular event (MACE), defined as a composite of all-cause mortality, HF hospitalization, left ventricular assist device (LVAD) or heart transplant, cardiac resynchronization therapy (CRT), CVA/transient ischemic attacks (TIA), VT and appropriate implantable cardioverter defibrillator (ICD) therapy.\nFocal myocardial thinning was observed in 42 patients (20%). Over a median follow-up time of 7 years (IQR, 4-10 years), 54 patients (24%) experienced a primary outcome. Patients with myocardial thinning had more cumulative adverse events than those without myocardial thinning (chi-square\u202f=\u202f29.516, log-rank < 0.001), even after matching for medical risk score. In a multivariate Cox regression model, myocardial thinning remained associated with outcomes: HR 3.052 (95% CI: 1.569-5.937, p=0.001).\nMyocardial thinning is associated with adverse cardiovascular events in LVNC patients. Incorporating myocardial thinning into medical risk assessments can improve the prediction and management of adverse outcomes in these patients.",
    "authors": [
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.",
            "firstname": "Tea",
            "initials": "T",
            "lastname": "Gegenava"
        },
        {
            "affiliation": "Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus Medical Center, Rotterdam, The Netherlands.",
            "firstname": "Martijn",
            "initials": "M",
            "lastname": "Tukker"
        },
        {
            "affiliation": "Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus Medical Center, Rotterdam, The Netherlands.",
            "firstname": "Kadir",
            "initials": "K",
            "lastname": "Caliskan"
        },
        {
            "affiliation": "Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.",
            "firstname": "Alexander",
            "initials": "A",
            "lastname": "Hirsch"
        },
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA.",
            "firstname": "Ashish",
            "initials": "A",
            "lastname": "Manohar"
        },
        {
            "affiliation": "Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.",
            "firstname": "Seung-Pyo",
            "initials": "SP",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA.",
            "firstname": "Anjali",
            "initials": "A",
            "lastname": "Owens"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.",
            "firstname": "Deborah H",
            "initials": "DH",
            "lastname": "Kwon"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.",
            "firstname": "Jay",
            "initials": "J",
            "lastname": "Ramchand"
        },
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.",
            "firstname": "Matthew T",
            "initials": "MT",
            "lastname": "Wheeler"
        },
        {
            "affiliation": "Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.",
            "firstname": "W H Wilson",
            "initials": "WHW",
            "lastname": "Tang"
        },
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA. Electronic address: knieman@stanford.edu.",
            "firstname": "Koen",
            "initials": "K",
            "lastname": "Nieman"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025. Published by Elsevier Inc.",
    "doi": "10.1016/j.amjcard.2025.04.018",
    "journal": "The American journal of cardiology",
    "keywords": [
        "Left ventricular non-compaction",
        "cardiac magnetic resonance imaging",
        "myocardial thinning"
    ],
    "methods": null,
    "publication_date": "2025-04-25",
    "pubmed_id": "40274207",
    "results": "Focal myocardial thinning was observed in 42 patients (20%). Over a median follow-up time of 7 years (IQR, 4-10 years), 54 patients (24%) experienced a primary outcome. Patients with myocardial thinning had more cumulative adverse events than those without myocardial thinning (chi-square\u202f=\u202f29.516, log-rank < 0.001), even after matching for medical risk score. In a multivariate Cox regression model, myocardial thinning remained associated with outcomes: HR 3.052 (95% CI: 1.569-5.937, p=0.001).",
    "title": "Prognostic Value of Compact Myocardial Thinning in Patients with Left Ventricular Non-compaction.",
    "xml": "<Element 'PubmedArticle' at 0x788505860540>"
}