{
    "abstract": "Alcohol use disorder is a prevalent and major but preventable cause of morbidity and mortality worldwide, causing several important health consequences, including chronic liver disease. Despite its substantial effects, most clinicians do not adequately assess alcohol intake in clinical practice, and there are several barriers to providing integrated management to patients with alcohol use disorder. Standardised questionnaires, such as the Alcohol Use Identification Test (AUDIT), can facilitate the identification of individuals at risk of alcohol use disorder, and alcohol biomarkers such as phosphatidylethanol aid in quantifying levels of alcohol consumption. Non-pharmacological interventions-including brief interventions, twelve-step facilitation, motivational enhancement therapy, contingency management, and cognitive behavioural therapy-are effective for patients with alcohol use disorder, regardless of the presence of advanced liver disease. Pharmacological treatments should be considered according to the severity of liver disease and other comorbidities, safety profile, and local availability. The management of patients with alcohol use disorder and associated liver disease should ideally be performed in the setting of integrated multidisciplinary teams.",
    "authors": [
        {
            "affiliation": "Departamento de Gastroenterolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile; MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, CA, USA.",
            "firstname": "Luis Antonio",
            "initials": "LA",
            "lastname": "D\u00edaz"
        },
        {
            "affiliation": "Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria.",
            "firstname": "Daniel",
            "initials": "D",
            "lastname": "K\u00f6nig"
        },
        {
            "affiliation": "Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria.",
            "firstname": "Sabine",
            "initials": "S",
            "lastname": "Weber"
        },
        {
            "affiliation": "Departamento de Gastroenterolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile.",
            "firstname": "Gustavo",
            "initials": "G",
            "lastname": "Ayares"
        },
        {
            "affiliation": "Escuela de Medicina, Universidad Finis Terrae, Santiago, Chile.",
            "firstname": "Jos\u00e9 Miguel",
            "initials": "JM",
            "lastname": "Fuentealba"
        },
        {
            "affiliation": "Escuela de Medicina, Instituto Tecnol\u00f3gico de Monterrey, Monterrey, Mexico.",
            "firstname": "Valeria",
            "initials": "V",
            "lastname": "V\u00e1zquez"
        },
        {
            "affiliation": "Liver Unit, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Barcelona, Spain.",
            "firstname": "Ramon",
            "initials": "R",
            "lastname": "Bataller"
        },
        {
            "affiliation": "Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.",
            "firstname": "Patrick S",
            "initials": "PS",
            "lastname": "Kamath"
        },
        {
            "affiliation": "Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.",
            "firstname": "Gerald Scott",
            "initials": "GS",
            "lastname": "Winder"
        },
        {
            "affiliation": "National Institutes of Health, Baltimore, MD, USA; National Institute on Drug Abuse, Baltimore, MD, USA; National Institute on Alcohol Abuse and Alcoholism, Baltimore, MD, USA.",
            "firstname": "Lorenzo",
            "initials": "L",
            "lastname": "Leggio"
        },
        {
            "affiliation": "Departamento de Gastroenterolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile; Stravitz-Sanyal Institute of Liver Disease and Metabolic Health, Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. Electronic address: juanpablo.arab@vcuhealth.org.",
            "firstname": "Juan Pablo",
            "initials": "JP",
            "lastname": "Arab"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.",
    "doi": "10.1016/S2468-1253(24)00380-7",
    "journal": "The lancet. Gastroenterology & hepatology",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-02-17",
    "pubmed_id": "39956128",
    "results": null,
    "title": "Management of alcohol use disorder: a gastroenterology and hepatology-focused perspective.",
    "xml": "<Element 'PubmedArticle' at 0x788503f19b20>"
}