{
    "abstract": "Oral lichen planus (OLP), a chronic inflammatory disease, can progress to oral squamous cell carcinoma (OSCC). The malignant transformation rate may be lower in OLP patients receiving anti-inflammatory therapy.\nTo describe cases of malignant transformation among OLP patients on topical/systemic anti-inflammatory therapy.\nThe medical records of 273 patients with OLP at an academic institution were retrospectively reviewed. Patients with epithelial dysplasia at OLP diagnosis were excluded. Biopsy-confirmed OSCC cases diagnosed \u22656 months after the initial visit were included. Chi-square and \nThe mean age at OLP diagnosis was 63 years (standard deviation [SD]: 12.2, range: 19-92); 79.9% were women and 89.4% were White. Most patients had erosive OLP (EOLP) (61.9%). 16.5% had concurrent genital LP and 10.6% had cutaneous LP. Tacrolimus swish-and-spit was the most frequently prescribed treatment (100%), followed by 10 mg clotrimazole troches (89.4%) and topical corticosteroids (85%). The median duration of clinical follow-up was 2.9 years (interquartile range: 1-5.5). Three (1.1%) patients developed OSCC on average 6.3 years post-OLP diagnosis, all with EOLP. OSCC most frequently affected the tongue (66.7%), followed by the gingiva (33.3%). Out of 3 tumours, one was stage II, one was stage III, and one was stage IV. OLP patients with vs. without OSCC were more often male (\nOSCC incidence was low in OLP patients on sustained anti-inflammatory therapy, occurring exclusively in those with EOLP. Males and patients with dysphagia more often developed OSCC.",
    "authors": [
        {
            "affiliation": "Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.",
            "firstname": "Jose W",
            "initials": "JW",
            "lastname": "Ricardo"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Max E",
            "initials": "ME",
            "lastname": "Oscherwitz"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Madison H",
            "initials": "MH",
            "lastname": "Read"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Angelina H",
            "initials": "AH",
            "lastname": "Wiater"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Christina",
            "initials": "C",
            "lastname": "Kontzias"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Jane B",
            "initials": "JB",
            "lastname": "Cleland"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.",
            "firstname": "Joseph",
            "initials": "J",
            "lastname": "Jorizzo"
        }
    ],
    "conclusions": "OSCC incidence was low in OLP patients on sustained anti-inflammatory therapy, occurring exclusively in those with EOLP. Males and patients with dysphagia more often developed OSCC.",
    "copyrights": null,
    "doi": "10.1177/12034754251324945",
    "journal": "Journal of cutaneous medicine and surgery",
    "keywords": [
        "corticosteroid",
        "erosive lichen planus",
        "lichen planus",
        "oral lichen planus",
        "oral mucosa",
        "squamous cell carcinoma"
    ],
    "methods": null,
    "publication_date": "2025-03-25",
    "pubmed_id": "40130514",
    "results": "The mean age at OLP diagnosis was 63 years (standard deviation [SD]: 12.2, range: 19-92); 79.9% were women and 89.4% were White. Most patients had erosive OLP (EOLP) (61.9%). 16.5% had concurrent genital LP and 10.6% had cutaneous LP. Tacrolimus swish-and-spit was the most frequently prescribed treatment (100%), followed by 10 mg clotrimazole troches (89.4%) and topical corticosteroids (85%). The median duration of clinical follow-up was 2.9 years (interquartile range: 1-5.5). Three (1.1%) patients developed OSCC on average 6.3 years post-OLP diagnosis, all with EOLP. OSCC most frequently affected the tongue (66.7%), followed by the gingiva (33.3%). Out of 3 tumours, one was stage II, one was stage III, and one was stage IV. OLP patients with vs. without OSCC were more often male (",
    "title": "Low Incidence of Oral Squamous Cell Carcinoma in Patients With Oral Lichen Planus on Sustained Anti-Inflammatory Therapy: A Single-Centre Retrospective Study of 273 Patients.",
    "xml": "<Element 'PubmedArticle' at 0x7885032d5fd0>"
}