{
    "abstract": "Left ventricular assist device (LVAD) implantation, a therapy for end-stage heart failure, is associated with platelet (PLT) activation. This study aims to evaluate the prognostic impact of PLT count in patients with LVAD implantation.\nData from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) registry were investigated, and patients were divided into three groups according to tertiles. The dynamic change of PLT counts and its associations with long-term outcomes were analysed. The primary outcome was long-term mortality. A total of 19\u00a0517 patients who received the first continuous-flow LVAD were identified from the INTERMACS registry. The PLT count underwent a dynamic change towards normalization after LVAD implantation. Compared with intermediate, both high (hazard ratio [HR], 1.09, 95% confidence interval [CI]: 1.01 to 1.17, P\u00a0=\u00a00.033) and low (HR, 1.18, 95% CI: 1.10 to 1.27, P\u00a0<\u00a00.001) pre-implant PLT counts were associated with an increased risk of 2\u00a0year mortality. Compared with intermediate, a high post-implant PLT count was associated with an increased risk of 4\u00a0year mortality (HR, 1.38, 95% CI: 1.26 to 1.52, P\u00a0<\u00a00.001). Besides, both pre- and post-implant PLT counts exhibit a U-shaped association with the risk of mortality.\nLVAD implantation could improve the PLT count towards normalization. Abnormal pre-/post-implant PLT counts were independently associated with increased risks of long-term mortality.",
    "authors": [
        {
            "affiliation": "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Jun",
            "initials": "J",
            "lastname": "Luo"
        },
        {
            "affiliation": "Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.",
            "firstname": "Zhenhan",
            "initials": "Z",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Yuxiang",
            "initials": "Y",
            "lastname": "Luo"
        },
        {
            "affiliation": "Department of Cardiac Surgery, Heinrich-Heine-University Medical School, Duesseldorf, Germany.",
            "firstname": "Tong",
            "initials": "T",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.",
            "firstname": "Rui",
            "initials": "R",
            "lastname": "Shi"
        },
        {
            "affiliation": "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Dan",
            "initials": "D",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Qingchen",
            "initials": "Q",
            "lastname": "Wu"
        },
        {
            "affiliation": "Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Suxin",
            "initials": "S",
            "lastname": "Luo"
        },
        {
            "affiliation": "Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Bi",
            "initials": "B",
            "lastname": "Huang"
        },
        {
            "affiliation": "Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.",
            "firstname": "Hongtao",
            "initials": "H",
            "lastname": "Tie"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",
    "doi": "10.1002/ehf2.14856\n10.1002/ejhf.1858\n10.1161/JAHA.120.019655\n10.1016/j.athoracsur.2020.12.038\n10.1016/j.healun.2017.07.005\n10.1007/s00134-020-05939-1\n10.3390/cells11061014\n10.1016/j.annepidem.2017.02.001\n10.1177/2048872620925257\n10.1182/blood-2015-06-654764\n10.1080/09537104.2020.1847266\n10.1093/eurheartj/ehl305\n10.1016/j.hlc.2015.11.010\n10.1001/jamacardio.2019.4965\n10.21037/atm.2018.02.12\n10.1002/ehf2.13390\n10.1161/CIRCULATIONAHA.117.031912\n10.1001/archinte.168.19.2138\n10.3324/haematol.2008.003178\n10.1093/ajcp/76.3.289\n10.1016/j.annepidem.2005.06.052\n10.1016/j.healun.2020.01.1076\n10.1080/09537104.2020.1859101\n10.5301/IJAO.2011.8459\n10.1155/2011/536062\n10.1097/00002480-200105000-00023\n10.1093/eurjhf/hfq061\n10.1038/s41591-018-0030-x\n10.3399/BJGP.2023.0684\n10.1016/j.ijcard.2014.01.001\n10.1016/j.amjcard.2006.01.046\n10.3760/cma.j.cn112338-20210320-00235",
    "journal": "ESC heart failure",
    "keywords": [
        "left ventricular assist device",
        "long\u2010term outcomes",
        "platelet count",
        "risk stratification"
    ],
    "methods": null,
    "publication_date": "2024-06-04",
    "pubmed_id": "38831637\n32483830\n34315285\n33465365\n28942782\n32016536\n35326465\n28320576\n32403936\n26265696\n33213236\n17028108\n30606941\n26868831\n31738366\n29955581\n33939298\n29661945\n18955644\n19286885\n7282629\n16246584\n33636040\n33347335\n21725928\n22084665\n11374772\n20427614\n29736022\n32698733\n24456878\n16784909\n29481654\n34814587",
    "results": null,
    "title": "Platelet count in heart failure patients undergoing left ventricular assist device.",
    "xml": "<Element 'PubmedArticle' at 0x7885043318a0>"
}