{
    "abstract": "Poly(ADP-ribose) polymerase-1 (PARP-1) plays a crucial role in DNA repair, mediating approximately 90\u00a0% of ADP-ribosylation processes associated with DNA damage response. Consequently, inhibiting PARP-1 with small molecules represents a promising strategy for cancer therapy. Utilizing a structure-based design and molecular hybridization approach, we developed three novel series of spirobenzoxazinone-piperdine/salicylamide-based derivatives. These compounds were evaluated for their in vitro PARP-1 inhibitory activity, and their structure-activity relationships were analyzed. At 10\u00a0\u00b5M concentration, derivatives (18a-d) demonstrated nearly complete inhibition, and the spirocyclic derivative (7c) also achieved a considerable inhibitory effect, with IC",
    "authors": [
        {
            "affiliation": "Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassaia, Cairo 11566, Egypt.",
            "firstname": "Alaa Ahmed",
            "initials": "AA",
            "lastname": "Kadry"
        },
        {
            "affiliation": "Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassaia, Cairo 11566, Egypt. Electronic address: mai.adel@pharma.asu.edu.eg.",
            "firstname": "Mai",
            "initials": "M",
            "lastname": "Adel"
        },
        {
            "affiliation": "Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia; Basic & Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.",
            "firstname": "Samar A",
            "initials": "SA",
            "lastname": "Abubshait"
        },
        {
            "affiliation": "Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt; Molecular Biology Institute of Barcelona, Spanish National Research Council, Catalonia, Spain.",
            "firstname": "Galal",
            "initials": "G",
            "lastname": "Yahya"
        },
        {
            "affiliation": "Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo 11796, Egypt.",
            "firstname": "Marwa",
            "initials": "M",
            "lastname": "Sharaky"
        },
        {
            "affiliation": "Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassaia, Cairo 11566, Egypt.",
            "firstname": "Rabah A T",
            "initials": "RAT",
            "lastname": "Serya"
        },
        {
            "affiliation": "Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassaia, Cairo 11566, Egypt. Electronic address: Khaled.abouzid@pharma.asu.edu.eg.",
            "firstname": "Khaled A M",
            "initials": "KAM",
            "lastname": "Abouzid"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier Ltd. All rights reserved.",
    "doi": "10.1016/j.bmc.2025.118173",
    "journal": "Bioorganic & medicinal chemistry",
    "keywords": [
        "Anti-cancer drug resistance",
        "Benzamide",
        "Cell lines",
        "Docking",
        "Olaparib",
        "PARP-1 inhibitors",
        "Spirobenzoxazinone"
    ],
    "methods": null,
    "publication_date": "2025-04-20",
    "pubmed_id": "40252565",
    "results": null,
    "title": "Targeting DNA repair mechanisms: Spirobenzoxazinone and salicylamide derivatives as novel candidates for PARP-1 inhibition in cancer therapy.",
    "xml": "<Element 'PubmedArticle' at 0x788502cebdd0>"
}