{
    "abstract": "Kidney injury is common in patients with cardiovascular disease.\nWe determined whether blood measurement of kidney injury molecule-1 (KIM-1), would predict kidney outcomes in patients undergoing angiographic procedures for various indications.\nOne thousand two hundred eight patients undergoing coronary and/or peripheral angiography were prospectively enrolled; blood was collected for KIM-1 measurement. Peri-procedural acute kidney injury (AKI) was defined as AKI within 48 hours of contrast exposure. Non-procedural AKI was defined as AKI beyond 48 hours. Development of chronic kidney disease (CKD) was defined as progression to an estimated glomerular filtration rate (eGFR) <60 milliliters/minute/1.73 m\nDuring mean follow up of 4 years, peri-procedural AKI occurred in 5.0%, non-procedural AKI in 27.3%, and 12.4% developed new reduction in eGFR <60 mL/min/1.73 m2. Higher KIM-1 concentrations were associated with prevalent comorbidities associated with risk in cardiovascular disease and worse left ventricular function. In adjusted analyses, elevated pre- and post-procedural KIM-1 concentrations predicted not only peri-procedural AKI (odds ratio [OR] 1.54, 95% confidence interval [CI] 1.09-2\u00b718, P\u202f=\u202f.01 and OR 1.54, 95% CI 1.10-2.15, P\u202f=\u202f.01, respectively) and non-procedural AKI (hazard ratio [HR] 1\u00b749, 95% CI 1\u00b724-1\u00b778, P\u202f<\u202f.001 and HR 1.46, 95% CI 1.23-1.74, P\u202f<\u202f.001, respectively), but also progression to CKD (OR 1.99, 95% CI 1.32-2.99, P\u202f=\u202f.001 and OR 2\u00b702, 95% CI 1\u00b735-3\u00b703, P\u202f=\u202f.001, respectively).\nIn a typical at-risk population undergoing coronary and/or peripheral angiography, blood concentrations of KIM-1 may predict incident peri-procedural and non-procedural AKI, as well as progression to CKD.",
    "authors": [
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.",
            "firstname": "Nasrien E",
            "initials": "NE",
            "lastname": "Ibrahim"
        },
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA.",
            "firstname": "Cian P",
            "initials": "CP",
            "lastname": "McCarthy"
        },
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA.",
            "firstname": "Shreya",
            "initials": "S",
            "lastname": "Shrestha"
        },
        {
            "affiliation": "Baim Institute for Clinical Research, Boston, MA; Department of Mathematics and Statistics, Boston University, Boston, MA.",
            "firstname": "Asya",
            "initials": "A",
            "lastname": "Lyass"
        },
        {
            "affiliation": "Baim Institute for Clinical Research, Boston, MA.",
            "firstname": "Yiwei",
            "initials": "Y",
            "lastname": "Li"
        },
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.",
            "firstname": "Hanna K",
            "initials": "HK",
            "lastname": "Gaggin"
        },
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA.",
            "firstname": "Mandy L",
            "initials": "ML",
            "lastname": "Simon"
        },
        {
            "affiliation": "Department of Biostatistics, Boston University, Boston, MA.",
            "firstname": "Joseph M",
            "initials": "JM",
            "lastname": "Massaro"
        },
        {
            "affiliation": "Baim Institute for Clinical Research, Boston, MA; Department of Mathematics and Statistics, Boston University, Boston, MA.",
            "firstname": "Ralph B",
            "initials": "RB",
            "lastname": "D'Agostino"
        },
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.",
            "firstname": "Joseph M",
            "initials": "JM",
            "lastname": "Garasic"
        },
        {
            "affiliation": "Cardiology Division, Radboud UMC and Cardiology Division, Maastricht UMC, Nijmegen, Netherlands.",
            "firstname": "Roland Rj",
            "initials": "RR",
            "lastname": "van Kimmenade"
        },
        {
            "affiliation": "Cardiology Division, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Baim Institute for Clinical Research, Boston, MA. Electronic address: jjanuzzi@partners.org.",
            "firstname": "James L",
            "initials": "JL",
            "lastname": "Januzzi"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2018 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.ahj.2018.12.001",
    "journal": "American heart journal",
    "keywords": [],
    "methods": null,
    "publication_date": "2019-01-15",
    "pubmed_id": "30641399",
    "results": "During mean follow up of 4 years, peri-procedural AKI occurred in 5.0%, non-procedural AKI in 27.3%, and 12.4% developed new reduction in eGFR <60 mL/min/1.73 m2. Higher KIM-1 concentrations were associated with prevalent comorbidities associated with risk in cardiovascular disease and worse left ventricular function. In adjusted analyses, elevated pre- and post-procedural KIM-1 concentrations predicted not only peri-procedural AKI (odds ratio [OR] 1.54, 95% confidence interval [CI] 1.09-2\u00b718, P\u202f=\u202f.01 and OR 1.54, 95% CI 1.10-2.15, P\u202f=\u202f.01, respectively) and non-procedural AKI (hazard ratio [HR] 1\u00b749, 95% CI 1\u00b724-1\u00b778, P\u202f<\u202f.001 and HR 1.46, 95% CI 1.23-1.74, P\u202f<\u202f.001, respectively), but also progression to CKD (OR 1.99, 95% CI 1.32-2.99, P\u202f=\u202f.001 and OR 2\u00b702, 95% CI 1\u00b735-3\u00b703, P\u202f=\u202f.001, respectively).",
    "title": "Blood kidney injury molecule-1 predicts short and longer term kidney outcomes in patients undergoing diagnostic coronary and/or peripheral angiography-Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study.",
    "xml": "<Element 'PubmedArticle' at 0x78850317ddf0>"
}