{
    "abstract": "Extracorporeal membrane oxygenation (ECMO) is widely used for children treated for refractory respiratory failures or refractory cardiogenic shock. Its duration depends on organ functions recovery. Weaning is decided using macro-circulatory tools, but microcirculation is not well evaluated. Sidestream dark-field video imaging is used to assess the perfusion of the sublingual microvascular vessels. The aim of this study was to assess the predictive value of microcirculatory indices in ECMO weaning.\nThis prospective monocentric study examined pediatric patients at Trousseau Hospital between March 2017 and December 2020. The study included all patients from 35\u2009weeks of gestational age to 18\u2009years old who were treated with ECMO. Children were divided into two groups: one with stability after weaning and the other with instability after weaning. We collected clinical and biological data, ventilation parameters, extracorporeal membrane oxygenation parameters, and drugs used at admission and after the weaning test. Microcirculations videos were taken after weaning trials with echocardiography and blood gas monitoring.\nThe study included 30 patients with a median age of 29\u2009days (range: 1-770\u2009days) at admission, including 18 patients who received venoarterial ECMO (60%). There were 19 children in the stability group and 11 in the instability group. Macrocirculatory and microcirculatory indices showed no differences between groups. The microvascular flow index was subnormal in both groups (2.3 (1.8-2.4) and 2.3 (2.3-2.6), respectively; p\u2009=\u20090.24). The microvascular indices were similar between cases of venovenous and venoarterial ECMO and between age groups.\nMicrocirculation monitoring at the weaning phase did not predict the failure of ECMO weaning.",
    "authors": [
        {
            "affiliation": "Neonatal and Pediatric Intensive Care Unit, Trousseau Hospital, AP-HP, Paris, France.",
            "firstname": "Violette",
            "initials": "V",
            "lastname": "Suc"
        },
        {
            "affiliation": "Neonatal and Pediatric Intensive Care Unit, Trousseau Hospital, AP-HP, Paris, France.",
            "firstname": "Julie",
            "initials": "J",
            "lastname": "Starck"
        },
        {
            "affiliation": "Neonatal and Pediatric Intensive Care Unit, Trousseau Hospital, AP-HP, Paris, France.\nMedicine Department, Sorbonne University, Paris, France.",
            "firstname": "Yael",
            "initials": "Y",
            "lastname": "Levy"
        },
        {
            "affiliation": "Neonatal and Pediatric Intensive Care Unit, Trousseau Hospital, AP-HP, Paris, France.\nMedicine Department, Sorbonne University, Paris, France.",
            "firstname": "Yohan",
            "initials": "Y",
            "lastname": "Soreze"
        },
        {
            "affiliation": "Neonatal and Pediatric Intensive Care Unit, Trousseau Hospital, AP-HP, Paris, France.\nMedicine Department, Sorbonne University, Paris, France.",
            "firstname": "Jerome",
            "initials": "J",
            "lastname": "Rambaud"
        },
        {
            "affiliation": "Neonatal and Pediatric Intensive Care Unit, Trousseau Hospital, AP-HP, Paris, France.\nMedicine Department, Sorbonne University, Paris, France.",
            "firstname": "Pierre-Louis",
            "initials": "PL",
            "lastname": "L\u00e9ger"
        }
    ],
    "conclusions": "Microcirculation monitoring at the weaning phase did not predict the failure of ECMO weaning.",
    "copyrights": "\u00a9 2024 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.",
    "doi": "10.1111/aor.14754",
    "journal": "Artificial organs",
    "keywords": [
        "extracorporeal membrane oxygenation",
        "microcirculation",
        "pediatric intensive care unit",
        "side\u2010stream dark field",
        "weaning"
    ],
    "methods": null,
    "publication_date": "2024-04-22",
    "pubmed_id": "38647271",
    "results": "The study included 30 patients with a median age of 29\u2009days (range: 1-770\u2009days) at admission, including 18 patients who received venoarterial ECMO (60%). There were 19 children in the stability group and 11 in the instability group. Macrocirculatory and microcirculatory indices showed no differences between groups. The microvascular flow index was subnormal in both groups (2.3 (1.8-2.4) and 2.3 (2.3-2.6), respectively; p\u2009=\u20090.24). The microvascular indices were similar between cases of venovenous and venoarterial ECMO and between age groups.",
    "title": "Predictive value of microcirculation for pediatric extracorporeal membrane oxygenation weaning test: A\u00a0monocentric prospective observational study.",
    "xml": "<Element 'PubmedArticle' at 0x7885030998f0>"
}