{
    "abstract": "Nail technicians (NTs) are exposed to a low-level mixture of volatile organic solvents (VOCs), yet the health hazards related to such exposure are unknown. This study thus aimed to compare the blood plasma levels of selected biomarkers related to liver status and lipid profile among occupationally exposed NTs and unexposed controls. Associations between out-of-normal-range levels of such biomarkers and occupational exposure to VOCs mixture have also been investigated.\nThe study enrolled 145 female NTs and 152 unexposed controls. Biochemical analyses were performed using spectrophotometric assays and obtained data were analyzed using general linear model and Poisson regression modelling adjusted to multiple confounders.\nCompared to controls, NTs presented significantly increased plasma activities of ALT (2.04\u2009\u00b1\u20090.63\u00a0ln-U/l vs. 1.25\u2009\u00b1\u20090.71\u00a0ln-U/l; p\u2009<\u20090.0001) and AST (2.73\u2009\u00b1\u20090.25\u00a0ln-U/l vs. 2.08\u2009\u00b1\u20090.95\u00a0ln-U/l; p\u2009<\u20090.0001), and significantly increased plasma levels of TG (4.38\u2009\u00b1\u20090.53\u00a0ln-mg/dl vs. 4.21\u2009\u00b1\u20090.42\u00a0ln-mg/dl; p\u2009<\u20090.05) and TC/HDL ratio (1.18\u2009\u00b1\u20090.36 vs. 1.02\u2009\u00b1\u20090.27; p\u2009<\u20090.0005). Plasma levels of HDL were significantly lower among NTs (4.02\u2009\u00b1\u20090.29\u00a0ln-mg/dl vs. 4.21\u2009\u00b1\u20090.26\u00a0ln-mg/dl; p\u2009<\u20090.0001). Moreover, NTs were found to present significantly increased risk of occurrence of clinically relevant plasma HDL levels below 3.91\u00a0ln-mg/dl (i.e., 50\u00a0mg/dl; RR\u2009=\u20091.58, 95% CI 1.07-2.32, p\u2009<\u20090.05), as well as increased risk of clinically relevant TC/HDL ratio above the normal range limit of 3.5 (RR\u2009=\u20091.68, 95% CI 1.19-2.35, p\u2009<\u20090.005), as compared to unexposed controls.\nNail technicians are subject to adverse changes in selected plasma biomarkers related to liver functions, some of which may be of clinical relevance.",
    "authors": [
        {
            "affiliation": "Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8, Sw. Teresy str., 91-348, Lodz, Poland. peter.gresner@imp.lodz.pl.",
            "firstname": "Peter",
            "initials": "P",
            "lastname": "Gre\u0161ner"
        },
        {
            "affiliation": "Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 8, Sw. Teresy str., 91-348, Lodz, Poland.",
            "firstname": "Magdalena Beata",
            "initials": "MB",
            "lastname": "Kr\u00f3l"
        },
        {
            "affiliation": "Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8, Sw. Teresy str., 91-348, Lodz, Poland.",
            "firstname": "Rados\u0142aw",
            "initials": "R",
            "lastname": "\u015awiercz"
        },
        {
            "affiliation": "Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 8, Sw. Teresy str., 91-348, Lodz, Poland.",
            "firstname": "Jolanta",
            "initials": "J",
            "lastname": "Gromadzi\u0144ska"
        }
    ],
    "conclusions": "Nail technicians are subject to adverse changes in selected plasma biomarkers related to liver functions, some of which may be of clinical relevance.",
    "copyrights": null,
    "doi": "10.1007/s00420-020-01599-2",
    "journal": "International archives of occupational and environmental health",
    "keywords": [
        "Cholesterol",
        "Combined exposure",
        "Glucose",
        "HDL",
        "Nail technician",
        "Transaminases",
        "VOC"
    ],
    "methods": null,
    "publication_date": "2020-11-07",
    "pubmed_id": "33156392\n17686177\n12455270\n11160987\n31112343\n31736299\n16688355\n26348975\n27453719\n28481379\n30275872\n21831819\n13221663\n14600835\n30081587\n26139993\n30933751\n17243950\n19117555\n22719183\n6825269\n17989147\n30997562\n26543313\n24328919\n24921020\n18478317\n21551383\n19753596\n17940905\n31772726\n25116426\n5776547\n18382476\n13323003\n20351028\n30276513",
    "results": "Compared to controls, NTs presented significantly increased plasma activities of ALT (2.04\u2009\u00b1\u20090.63\u00a0ln-U/l vs. 1.25\u2009\u00b1\u20090.71\u00a0ln-U/l; p\u2009<\u20090.0001) and AST (2.73\u2009\u00b1\u20090.25\u00a0ln-U/l vs. 2.08\u2009\u00b1\u20090.95\u00a0ln-U/l; p\u2009<\u20090.0001), and significantly increased plasma levels of TG (4.38\u2009\u00b1\u20090.53\u00a0ln-mg/dl vs. 4.21\u2009\u00b1\u20090.42\u00a0ln-mg/dl; p\u2009<\u20090.05) and TC/HDL ratio (1.18\u2009\u00b1\u20090.36 vs. 1.02\u2009\u00b1\u20090.27; p\u2009<\u20090.0005). Plasma levels of HDL were significantly lower among NTs (4.02\u2009\u00b1\u20090.29\u00a0ln-mg/dl vs. 4.21\u2009\u00b1\u20090.26\u00a0ln-mg/dl; p\u2009<\u20090.0001). Moreover, NTs were found to present significantly increased risk of occurrence of clinically relevant plasma HDL levels below 3.91\u00a0ln-mg/dl (i.e., 50\u00a0mg/dl; RR\u2009=\u20091.58, 95% CI 1.07-2.32, p\u2009<\u20090.05), as well as increased risk of clinically relevant TC/HDL ratio above the normal range limit of 3.5 (RR\u2009=\u20091.68, 95% CI 1.19-2.35, p\u2009<\u20090.005), as compared to unexposed controls.",
    "title": "Blood plasma levels of biomarkers of liver status and lipid profile among nail technicians occupationally exposed to low-level mixture of volatile organic compounds.",
    "xml": "<Element 'PubmedArticle' at 0x788503e00180>"
}