{
    "abstract": "Incorporating ancient wisdom from Unani Medicine, this study delves into the therapeutic efficacy of Juniperus communis L. in primary dysmenorrhea. By seamlessly merging traditional knowledge with modern scientific evaluation, this research illuminates Juniperus communis L. (Juniper) potential. This study stands as a testament to the value of exploring ethnopharmacological insights and bridging the gap between ancient healing traditions and evidence-based medicine.\nTo assess the efficacy and safety of Juniper berry compared to mefenamic acid in menstrual cramps and its associated symptoms, and overall quality of life in women with PD. Additionally, the study aimed to explore the impact of these interventions on uterine blood flow using Doppler evaluation.\nThis was a double-blind, standard-controlled study conducted on 62 participants aged 18-35 years. They were randomly assigned to receive either two capsules (750\u00a0mg) of Juniper berry or 250\u00a0mg mefenamic acid thrice daily from day 1 to day 3 of menstruation, spanning two menstrual cycles. Primary outcomes were measured using the Visual Analogue Scale (VAS) for pain intensity and the Numerical Rating Scale (NRS) for systemic symptoms. Pelvic Doppler flow indices and responses to the SF-12 questionnaire were analyzed as secondary outcomes.\nAfter the intervention in cycle 2, both the juniper and standard groups exhibited a significant reduction in mean VAS scores from 8.1\u00a0\u00b1\u00a01.3 to 2.87\u00a0\u00b1\u00a01.17 and 8.1\u00a0\u00b1\u00a01.13 to 3.61\u00a0\u00b1\u00a01.14, respectively (p\u00a0=\u00a00.012). Intergroup comparisons revealed no statistically significant differences in systemic symptoms at baseline, and cycle 2 (C2) follow-up (p\u00a0>\u00a00.05). Similarly, there were no significant differences in the SF-12 questionnaire scores at baseline, C2, and C4 (p\u00a0>\u00a00.05). However, intragroup comparisons for VAS, NRS, and SF-12 in both groups showed significant differences at C2 and C4 compared to the baseline (p\u00a0<\u00a00.001). In the juniper group, intergroup and intragroup comparisons indicated a small effect size for the right uterine artery (Rt UtA) RI and SD at C3 compared to C1 (0.2 and 0.33). Left UtA-PI and RI also demonstrated a medium effect size (0.482 and 0.501), respectively, between C3 and C1.\nJuniper demonstrated significant efficacy and safety in reducing menstrual cramps, and its associated symptoms and improving health-related quality of life. Further, changes in pelvic uterine artery flow indices were also observed.",
    "authors": [
        {
            "affiliation": "Department of Ilmul Qabalat Wa Amraze Niswan (Gynecology and Obstetrics), Gynecology and Obstetrics, National Institute of Unani Medicine, Ministry of Ayush, GOI, Bengaluru, India. Electronic address: drtaseen5nium@gmail.com.",
            "firstname": "Taseen",
            "initials": "T",
            "lastname": "Banu"
        },
        {
            "affiliation": "Department of Ilmul Qabalat Wa Amraze Niswan (Gynecology and Obstetrics), National Institute of Unani Medicine, Ministry of Ayush, GOI, Bengaluru, India. Electronic address: drarshiya@yahoo.com.",
            "firstname": "Arshiya",
            "initials": "A",
            "lastname": "Sultana"
        },
        {
            "affiliation": "Department of Ilmul Qabalat Wa Amraze Niswan (Gynecology and Obstetrics), National Institute of Unani Medicine, Ministry of Ayush, GOI, Bengaluru, India. Electronic address: arfasiddiqui770404@gmail.com.",
            "firstname": "Arfa",
            "initials": "A",
            "lastname": "Begum"
        },
        {
            "affiliation": "Dept of Mahiyatul Amraz, National Institute of Unani Medicine, Ministry of Ayush, GOI, Ghaziabad, India. Electronic address: sidranium@gmail.com.",
            "firstname": null,
            "initials": null,
            "lastname": "Sidra"
        },
        {
            "affiliation": "Department of Ilmul Saidla (Pharmacy), National Institute of Unani Medicine, Ministry of Ayush, GOI, Bengaluru, India. Electronic address: r.khaleeq@yahoo.com.",
            "firstname": "Khaleequr",
            "initials": "K",
            "lastname": "Rahman"
        }
    ],
    "conclusions": "Juniper demonstrated significant efficacy and safety in reducing menstrual cramps, and its associated symptoms and improving health-related quality of life. Further, changes in pelvic uterine artery flow indices were also observed.",
    "copyrights": "Copyright \u00a9 2025 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jep.2025.119388",
    "journal": "Journal of ethnopharmacology",
    "keywords": [
        "Abhal",
        "Juniper berry",
        "Juniperus communis L.",
        "Pelvic uterine artery Doppler indices",
        "Primary dysmenorrhea (PD)",
        "Visual analogue scale (VAS)"
    ],
    "methods": null,
    "publication_date": "2025-01-23",
    "pubmed_id": "39842749",
    "results": "After the intervention in cycle 2, both the juniper and standard groups exhibited a significant reduction in mean VAS scores from 8.1\u00a0\u00b1\u00a01.3 to 2.87\u00a0\u00b1\u00a01.17 and 8.1\u00a0\u00b1\u00a01.13 to 3.61\u00a0\u00b1\u00a01.14, respectively (p\u00a0=\u00a00.012). Intergroup comparisons revealed no statistically significant differences in systemic symptoms at baseline, and cycle 2 (C2) follow-up (p\u00a0>\u00a00.05). Similarly, there were no significant differences in the SF-12 questionnaire scores at baseline, C2, and C4 (p\u00a0>\u00a00.05). However, intragroup comparisons for VAS, NRS, and SF-12 in both groups showed significant differences at C2 and C4 compared to the baseline (p\u00a0<\u00a00.001). In the juniper group, intergroup and intragroup comparisons indicated a small effect size for the right uterine artery (Rt UtA) RI and SD at C3 compared to C1 (0.2 and 0.33). Left UtA-PI and RI also demonstrated a medium effect size (0.482 and 0.501), respectively, between C3 and C1.",
    "title": "Efficacy and safety of abhal (Juniperus communis L). on pain intensity, uterine artery doppler flow, and quality of life in primary dysmenorrhea: A double-blind, randomized controlled trial.",
    "xml": "<Element 'PubmedArticle' at 0x788504770270>"
}