{
    "abstract": "The purpose of our study was to investigate the curative effect of an enriched total oligomers \ufb02avonoids (TOF) extract from Rhamnus alaternus on ethanol-induced rat hepatic injury. We investigated the effects of R. alaternus in adult Wistar rats administered the drug (20 mg/kg) along with 4 g/kg of 40% ethanol. The findings noted that treatment with ethanol caused an increase in serum liver function parameters (alanine transferases, aspartate transaminase, and total bilirubin), in tumor necrosis factor alpha (TNF-\u03b1), in interleukin 1 beta (IL-1-\u03b2), in granulocyte-macrophage colony-stimulating factor (GM-CSF) and in MDA levels and a decrease in hepatic antioxidant activities, including superoxide dismutase, glutathione peroxidase, and glutathion.\u00a0 In addition, it intensified histopathological changes in the liver, as revealed by mononuclear cells' infiltration and steatosis compared to control. When compared to the ethanol-alone treated group, the rat receiving ethanol plus TOF extract exhibited significant decrease in serum liver function parameters, in TNF-\u03b1, in IL-1-\u03b2 in GM-CSF and malondialdehyde levels and increased hepatic antioxidant activities. Histopathological observations confirmed the curative effect of TOF against ethanol-induced liver injury in rats. These results suggest that TOF extract from R. alaternus has hepatoprotective effect by elevating antioxidative potentials and levels of pro-inflammatory cytokines.",
    "authors": [
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir: Universite de Monastir Faculte de Medecine Dentaire de Monastir, sciences fandamentales, 5000 RUE AVICENNE, 5000, Monastir, TUNISIA.",
            "firstname": "Ines",
            "initials": "I",
            "lastname": "Bouhlel"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Tahsine",
            "initials": "T",
            "lastname": "Kosksi"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Salima",
            "initials": "S",
            "lastname": "Selmi"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Arem",
            "initials": "A",
            "lastname": "Selmi"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Marwa",
            "initials": "M",
            "lastname": "Rejeb"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Nawres",
            "initials": "N",
            "lastname": "Debbabi"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Soumaya",
            "initials": "S",
            "lastname": "Kilani Jaziri"
        },
        {
            "affiliation": "University of Monastir Faculty of Dental Medicine of Monastir, sciences fondamentales, rue avicenne, monastir, TUNISIA.",
            "firstname": "Leila",
            "initials": "L",
            "lastname": "Chekir Ghedira"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 Wiley\u2010VCH GmbH.",
    "doi": "10.1002/cbdv.202500115",
    "journal": "Chemistry & biodiversity",
    "keywords": [
        "Antioxidant",
        "Hepatoprotection",
        "Rhamnus alaternus",
        "alcohol",
        "anti- inflammation"
    ],
    "methods": null,
    "publication_date": "2025-04-23",
    "pubmed_id": "40267411",
    "results": null,
    "title": "Antioxidant, Antigenotoxic and Anti-inflammatory Properties of Rhamnus alaternus Leaves Extract Against Ethanol-induced Liver Injury in Rat Model.",
    "xml": "<Element 'PubmedArticle' at 0x788503847650>"
}