{
    "abstract": "Aging-associated left ventricular dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right ventricular failure. At the time of diagnosis, cardiac function has declined, and cardiopulmonary fibrosis has often developed. Here, we sought to develop a molecular positron emission tomography (PET)-magnetic resonance imaging (MRI) protocol to detect both cardiopulmonary fibrosis and fibrotic disease activity in a left ventricular dysfunction model.\nLeft ventricular dysfunction was induced by transverse aortic constriction (TAC) in 6-month-old senescence-accelerated prone mice, a subset of mice that received sham surgery. Three weeks after surgery, mice underwent simultaneous PET-MRI at 4.7 T. Collagen-targeted PET and fibrogenesis magnetic resonance (MR) probes were intravenously administered. PET signal was computed as myocardium- or lung-to-muscle ratio. Percent signal intensity increase and \u0394 lung-to-muscle ratio were computed from the pre-/postinjection magnetic resonance images. Elevated allysine in the heart (\nAdministration of collagen-targeted PET and allysine-targeted MR probes led to elevated PET-magnetic resonance imaging signals in the myocardium and lungs of TAC mice. The study demonstrates the potential to detect fibrosis and fibrogenesis in cardiopulmonary disease through a dual molecular PET-magnetic resonance imaging protocol.",
    "authors": [
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Brianna F",
            "initials": "BF",
            "lastname": "Moon"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Iris Y",
            "initials": "IY",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Yingying",
            "initials": "Y",
            "lastname": "Ning"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.",
            "firstname": "Yin-Ching I",
            "initials": "YI",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Mariane",
            "initials": "M",
            "lastname": "Le Fur"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Sergey",
            "initials": "S",
            "lastname": "Shuvaev"
        },
        {
            "affiliation": "Department of Medicine, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School Boston MA USA.",
            "firstname": "Eman A",
            "initials": "EA",
            "lastname": "Akam"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Hua",
            "initials": "H",
            "lastname": "Ma"
        },
        {
            "affiliation": "Bruker BioSpin, Preclinical Imaging Billerica MA USA.",
            "firstname": "Cesar Molinos",
            "initials": "CM",
            "lastname": "Solsona"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.",
            "firstname": "Jonah",
            "initials": "J",
            "lastname": "Weigand-Whittier"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Nicholas",
            "initials": "N",
            "lastname": "Rotile"
        },
        {
            "affiliation": "Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School Boston MA USA.",
            "firstname": "Lida P",
            "initials": "LP",
            "lastname": "Hariri"
        },
        {
            "affiliation": "Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School Boston MA USA.",
            "firstname": "Matthew",
            "initials": "M",
            "lastname": "Drummond"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Avery T",
            "initials": "AT",
            "lastname": "Boice"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Samantha E",
            "initials": "SE",
            "lastname": "Zygmont"
        },
        {
            "affiliation": "Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.",
            "firstname": "Yamini",
            "initials": "Y",
            "lastname": "Sharma"
        },
        {
            "affiliation": "Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.",
            "firstname": "Rod R",
            "initials": "RR",
            "lastname": "Warburton"
        },
        {
            "affiliation": "Molecular Cardiology Research Institute, Tufts Medical Center Boston MA USA.",
            "firstname": "Gregory L",
            "initials": "GL",
            "lastname": "Martin"
        },
        {
            "affiliation": "Molecular Cardiology Research Institute, Tufts Medical Center Boston MA USA.",
            "firstname": "Robert M",
            "initials": "RM",
            "lastname": "Blanton"
        },
        {
            "affiliation": "Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.",
            "firstname": "Barry L",
            "initials": "BL",
            "lastname": "Fanburg"
        },
        {
            "affiliation": "Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.",
            "firstname": "Nicholas S",
            "initials": "NS",
            "lastname": "Hill"
        },
        {
            "affiliation": "Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.\nInstitute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA.",
            "firstname": "Peter",
            "initials": "P",
            "lastname": "Caravan"
        },
        {
            "affiliation": "Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.",
            "firstname": "Krishna C",
            "initials": "KC",
            "lastname": "Penumatsa"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1161/JAHA.124.034363\n10.1016/j.healun.2012.06.002\n10.1016/j.jacc.2013.10.033\n10.3181/00379727-60-15095\n10.1161/JAHA.122.029024\n10.1161/CIRCULATIONAHA.106.632208\n10.1093/eurheartj/ehv512\n10.1002/ehf2.12316\n10.1161/HYPERTENSIONAHA.111.186072\n10.1016/j.arr.2016.10.006\n10.1161/CIRCHEARTFAILURE.113.000887\n10.1183/09059180.00003912\n10.1148/radiol.2018180603\n10.1002/jmri.27849\n10.1161/JAHA.121.025143\n10.1161/CIRCULATIONAHA.118.035326\n10.1002/ehf2.12565\n10.1016/j.cjca.2014.12.028\n10.1113/JP275858\n10.1126/scitranslmed.aaf4696\n10.2967/jnumed.117.193532\n10.1371/journal.pone.0070802\n10.1161/CIRCRESAHA.119.311148\n10.1164/rccm.201903-0503LE\n10.2967/jnumed.122.264530\n10.1172/jci.insight.91506\n10.1002/anie.201704773\n10.1039/c9sc04821a\n10.1126/scitranslmed.abq6297\n10.1021/jacs.2c06231\n10.1681/ASN.0000000000000148\n10.1148/radiol.2020192118\n10.1038/s41598-021-85679-4\n10.1021/jacs.3c04964\n10.1038/s41598-019-42209-7\n10.1038/nprot.2016.060\n10.1162/15353500200303133\n10.1152/japplphysiol.00987.2016\n10.1186/s12876-019-1100-3\n10.1096/fj.201902155R\n10.1172/jci.insight.148003\n10.1016/S1570-0232(03)00248-4\n10.1016/j.jchromb.2017.08.032\n10.1038/s41569-020-0363-2\n10.1016/j.jacc.2019.06.053\n10.1161/CIRCRESAHA.121.318159\n10.1152/ajpheart.00238.2018\n10.3389/fphys.2020.560019\n10.1165/rcmb.2013-0039OC\n10.1002/anie.200700700\n10.1148/radiol.2473070975\n10.1016/j.jhep.2015.04.029\n10.1016/j.jhep.2012.04.035\n10.1016/j.jhep.2013.06.026\n10.1016/j.pharmthera.2023.108438\n10.1164/rccm.202201-0142OC\n10.1186/s12931-022-02241-0\n10.1161/01.cir.100.19.1992\n10.1056/NEJM200011163432003\n10.1148/radiology.218.1.r01ja50215\n10.1186/s12968-016-0308-4\n10.1186/1532-429X-15-92\n10.1152/ajpheart.00723.2004\n10.1152/ajpregu.00825.2009",
    "journal": "Journal of the American Heart Association",
    "keywords": [
        "[68Ga]CBP8",
        "allysine",
        "collagen",
        "fibrogenesis",
        "heart failure",
        "pulmonary hypertension"
    ],
    "methods": null,
    "publication_date": "2024-07-09",
    "pubmed_id": "38979786\n22884380\n24355634\n21004035\n37026538\n17060398\n26508169\n30030912\n22508832\n27825897\n24249049\n22941889\n30351254\n34350655\n36062610\n30615500\n31903694\n25840094\n30549058\n28381537\n28611243\n23936252\n33224773\n31219741\n31161770\n37116909\n28570270\n28677860\n32728411\n36130015\n35998740\n37094382\n32343209\n33731798\n37589185\n30971724\n21595115\n27172166\n14649056\n28126909\n31711420\n31914588\n34357881\n12798203\n28886479\n32231333\n31395131\n33983831\n30004258\n33041859\n23927643\n17893943\n18403626\n26022693\n22634342\n23838178\n37210005\n35763380\n36376885\n10556226\n11078769\n11152805\n27899132\n24124732\n15374829\n20375266",
    "results": null,
    "title": "Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular Dysfunction.",
    "xml": "<Element 'PubmedArticle' at 0x788505630a90>"
}