{
    "abstract": "To evaluate the retinal response to myopic defocus after the wear of soft multifocal contact lenses with high addition through electroretinography.\nTwenty-seven participants meeting inclusion criteria were enrolled. Tropicamide 1% drops (2) were instilled. Participants were then fitted with three different contact lenses: a single-vision spherical lens (SE +3.00 D), L1, serving as a control, and two soft multifocal lens designs (SE +3.00 D/add +10 D), one with a central distance zone of 4.0 mm (L2) and one with a central distance zone of 7.0 mm (L3). A global flash multifocal electroretinography was performed. Direct component (DC) amplitude, DC peak time, induced component (IC) amplitude, and IC peak time were recorded. Waveforms were grouped into five concentric areas, covering from 0\u00b0 to 24\u00b0 of retinal eccentricity. Differences of L2/L3 versus L1 were analyzed with t tests. Finally, correlations were calculated between the percentage of defocus in the pupil area versus the electroretinography results.\nResults show that the DC amplitude, caused mainly by photoreceptors and bipolar cells, is not influenced by the design of the lenses. The IC amplitude, however, is significantly decreased when the lens with a smaller optical zone (L2) is worn. This significant difference only concerns the ring 5, which corresponds to a retinal eccentricity of 15.7\u00b0 to 24.0\u00b0.\nSoft multifocal lens designs influence the peripheral retinal reaction to defocus. A larger treatment zone seems to significantly impact the retinal response to defocus between 15.7\u00b0 and 24.0\u00b0 of eccentricity from the macula.",
    "authors": [
        {
            "affiliation": "Optometry School, University of Montreal, Montreal, QC, Canada.",
            "firstname": "Laurence",
            "initials": "L",
            "lastname": "Boily"
        },
        {
            "affiliation": null,
            "firstname": "Langis",
            "initials": "L",
            "lastname": "Michaud"
        },
        {
            "affiliation": null,
            "firstname": "Marie-Lou",
            "initials": "ML",
            "lastname": "Garon"
        },
        {
            "affiliation": null,
            "firstname": "R\u00e9my",
            "initials": "R",
            "lastname": "Marcotte"
        }
    ],
    "conclusions": "Soft multifocal lens designs influence the peripheral retinal reaction to defocus. A larger treatment zone seems to significantly impact the retinal response to defocus between 15.7\u00b0 and 24.0\u00b0 of eccentricity from the macula.",
    "copyrights": "Copyright \u00a9 2024 Contact Lens Association of Ophthalmologists.",
    "doi": "10.1097/ICL.0000000000001099",
    "journal": "Eye & contact lens",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-05-17",
    "pubmed_id": "38758160",
    "results": "Results show that the DC amplitude, caused mainly by photoreceptors and bipolar cells, is not influenced by the design of the lenses. The IC amplitude, however, is significantly decreased when the lens with a smaller optical zone (L2) is worn. This significant difference only concerns the ring 5, which corresponds to a retinal eccentricity of 15.7\u00b0 to 24.0\u00b0.",
    "title": "Effects of Optical Zone Variation of High-Addition Multifocal Contact Lenses on the Global Flash Multifocal Electroretinography.",
    "xml": "<Element 'PubmedArticle' at 0x788504902ed0>"
}