{
    "abstract": "Vaginal structural defects are involved in pelvic organ prolapse (POP). We tested whether mesenchymal stem cell (MSC) therapy can repair the weakened vaginal wall of POP patients as a novel POP treatment. Ninety-six ovariectomized rats were divided into 4 groups (n\u2009=\u200924/group): saline (sal), collagen (col), sal\u2009+\u2009MSC, and col\u2009+\u2009MSC groups. Two weeks after ovariectomy, rats received subepithelial injection of 0.3\u00a0ml saline, 0.3\u00a0ml collagen I gel, and 0.3\u00a0ml saline: 3\u2009\u00d7\u200910",
    "authors": [
        {
            "affiliation": "Departments of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.\nDepartment of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.",
            "firstname": "Meng",
            "initials": "M",
            "lastname": "Mao"
        },
        {
            "affiliation": "Medical Science Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.",
            "firstname": "Yaqian",
            "initials": "Y",
            "lastname": "Li"
        },
        {
            "affiliation": "Departments of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.",
            "firstname": "Ye",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Departments of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.",
            "firstname": "Jia",
            "initials": "J",
            "lastname": "Kang"
        },
        {
            "affiliation": "Departments of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. zhu_julie@vip.sina.com.",
            "firstname": "Lan",
            "initials": "L",
            "lastname": "Zhu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
    "doi": "10.1007/s00441-021-03478-9\n10.1007/s00192-011-1384-5\n10.1016/j.ucl.2018.08.008\n10.1016/j.fertnstert.2012.05.038\n10.1007/s00192-013-2169-9\n10.1007/s00192-012-1927-4\n10.1067/mob.2002.124843\n10.1067/mob.2002.130005\n10.1007/s11934-014-0425-2\n10.1016/j.jep.2011.02.011\n10.1016/j.actbio.2016.05.010\n10.1097/00003081-199312000-00014\n10.1038/srep45709\n10.1016/j.ajog.2007.03.040\n10.1007/s00192-007-0459-9\n10.1002/nau.20798\n10.1089/scd.2011.0674\n10.1371/journal.pone.0044791\n10.1016/j.bbrc.2007.01.045\n10.1016/S0140-6736(07)60462-0\n10.1111/j.1471-0528.2008.01845.x\n10.1089/ten.tea.2010.0010\n10.1007/s00192-008-0737-1\n10.1007/s00404-010-1518-x\n10.5966/sctm.2013-0197\n10.1007/s12195-009-0090-6\n10.1016/j.ajog.2004.07.008\n10.1097/GCO.0b013e32830fe3c1\n10.1097/AOG.0b013e3182397009\n10.1177/0963689717722787\n10.1016/j.ajog.2008.02.022\n10.1016/j.stem.2012.02.005\n10.1073/pnas.0604850103\n10.1007/s00192-015-2831-5\n10.1097/AOG.0b013e3181f73729\n10.1016/j.juro.2006.03.070\n10.1152/ajprenal.00230.2017\n10.1016/j.juro.2012.05.017",
    "journal": "Cell and tissue research",
    "keywords": [
        "Collagen",
        "Human umbilical cord mesenchymal stem cells",
        "Pelvic organ prolapse",
        "Smooth muscle",
        "Vaginal wall"
    ],
    "methods": null,
    "publication_date": "2021-07-16",
    "pubmed_id": "34264376\n31467917\n24083684",
    "results": null,
    "title": "Human umbilical cord mesenchymal stem cells reconstruct the vaginal wall of ovariectomized Sprague-Dawley rats: implications for pelvic floor reconstruction.",
    "xml": "<Element 'PubmedArticle' at 0x78850329d490>"
}