{
    "abstract": "Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening and life-limiting disease with high mortality and disability rates. Herein, we aim to explore the preventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aSAH. Retrospectively, the medical data of patients with aSAH ( n \u2005=\u2005256) were collected. According to different treatment methods, patients were categorized into the aminocaproic acid\u2005+\u2005nimodipine group ( n \u2005=\u2005152) and the nimodipine group ( n \u2005=\u2005104), and were treated for 1\u2005week. Baseline characteristics, incidence of rebleeding, average velocity of cerebral artery blood flow, cerebral vasospasm index, vascular endothelial function, complications, and adverse events were analyzed between the two groups. After 1-week treatment, compared to the nimodipine group, the aminocaproic acid\u2005+\u2005nimodipine group exhibited lower incidence of rebleeding, notable decreases in average velocity of cerebral artery blood flow and the cerebral vasospasm index, and downregulation of endothelin-1 and vascular endothelial growth factor ( P \u2005<\u20050.05). There were no significant differences about complications and adverse events between the two groups. Aminocaproic acid combined with nimodipine is superior to nimodipine alone in preventing the short-term rebleeding in patients with aSAH, and has good safety.",
    "authors": [
        {
            "affiliation": "Department of Clinical Medicine, Henan Vocational College of Nursing Internal.",
            "firstname": "Qiong",
            "initials": "Q",
            "lastname": "Zhao"
        },
        {
            "affiliation": "Department of Neurosurgery, Anyang Third People's Hospital.",
            "firstname": "Zhongyang",
            "initials": "Z",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Neurology, The People's Hospital of Anyang City, Anyang, Henan Province, China.",
            "firstname": "Qingcheng",
            "initials": "Q",
            "lastname": "Yang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Wolters Kluwer Health, Inc. All rights reserved.",
    "doi": "10.1097/WNR.0000000000002127",
    "journal": "Neuroreport",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-12-11",
    "pubmed_id": "39661526",
    "results": null,
    "title": "Preventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aneurysmal subarachnoid hemorrhage.",
    "xml": "<Element 'PubmedArticle' at 0x78850612aed0>"
}