{
    "abstract": "A clinical trial involving 359 mares was conducted to ascertain the clinical value of a synthetic prostaglandin analogue (fluprostenol, ICI-81,008) structurally related to PGF2oc for treating mares in prolonged dioestrus. Some 263 mares (73.3%) displayed oestrus within 5 days of a first intramuscular injection of 250 mug fluprostenol and, of those mares later examined for pregnancy, 108 (40%) were found to have conceived during the first induced oestrus. A further 21 mares (8%) cycled normally and conceived to services during the second oestrus. Most (80.3%) of the plasma samples obtained from 242 mares prior to treatment showed a progesterone concentration greater than 1 ng/ml, thereby indicating the presence of functional luteal tissue in the ovaries. The results support earlier observations that most non-pregnant mares which fail to cycle during the breeding season are in a state of prolonged dioestrus rather than anoesturs.\n359 mares were treated with fluprostenol (250 mcg) in order to induce estrus. The mares fell into the following catagories: 1) abortion or resorption of the conceptus had occurred during the first 150 days of pregnancy, 2) pseudopregnant, 3) lactating mares without regular estrous cycles, and 4) barren and maiden mares without cycles during the breeding season. The treatment was administered a 2nd time if the animal failed to show signs of estrus within 5 days. 263 (73.3%) of the mares showed signs of estrus within 5 days of the 1st injection. A further 29 (8.1%) responded to the 2nd injection. 67 mares were unresponsive to treatment, although 35 showed signs of estrus 7-23 days after the 2nd injection. 51.5% of the mares conceived after therapy. Plasma progesterone (P) levels were measured prior to treatment. 80.3% were found to have levels greater than 1 ng/ml prior to treatment. Lactating animals had the highest proportion of P greater than 1 ng/ml. 16.5% of those mares with P levels less than 1 ng/ml responded to treatment in the 1st attempt. Of those mares who were unresponsiveto fluprostenol, 15 had P levels less than 1 ng/ml when treated.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "G E",
            "initials": "GE",
            "lastname": "Shepherd"
        },
        {
            "affiliation": null,
            "firstname": "J K",
            "initials": "JK",
            "lastname": "Findlay"
        },
        {
            "affiliation": null,
            "firstname": "M J",
            "initials": "MJ",
            "lastname": "Cooper"
        },
        {
            "affiliation": null,
            "firstname": "W R",
            "initials": "WR",
            "lastname": "Allen"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1111/j.1751-0813.1976.tb09484.x",
    "journal": "Australian veterinary journal",
    "keywords": [
        "Abortion, Induced",
        "Abortion, Spontaneous",
        "Animals, Laboratory",
        "Biology",
        "Clinical Research",
        "Diseases",
        "Endocrine System",
        "Hormones",
        "Lactation",
        "Maternal Physiology",
        "Menstrual Cycle",
        "Menstruation",
        "Ovulation",
        "Physiology",
        "Pregnancy",
        "Pregnancy Complications",
        "Progestational Hormones",
        "Progesterone--analysis",
        "Prostaglandins--administraction and dosage",
        "Pseudopregnancy",
        "Reproduction",
        "Research Methodology"
    ],
    "methods": null,
    "publication_date": "1976-08-01",
    "pubmed_id": "985255",
    "results": null,
    "title": "The use of synthetic prostaglandin analogue to induce oestrus in mares.",
    "xml": "<Element 'PubmedArticle' at 0x78850346c180>"
}