{
    "abstract": "Subcutaneous (SC) saline irrigation was reported as a feasible and cost-effective procedure to prevent cesarean section (CS) surgical site complications. We aim to investigate the efficacy of SC saline irrigation to prevent CS surgical site complications. A systematic review and meta-analysis were conducted synthesizing evidence from randomized controlled trial\u00a0(RCT) studies obtained from PubMed, Embase Cochrane, Scopus, and Web of Science from inception to March 2024. Pooled outcomes included wound complications (superficial surgical site infections (SSI), hematoma, seroma, and wound separation) and operative time. We used RevMan v.5.4. (The\u00a0Cochrane\u00a0Collaboration, Oxford, UK) to report dichotomous outcomes using risk ratio (RR) and continuous outcomes using mean differences (MD) with a 95% confidence interval (CI). Five RCTs with 4,025 patients were included. Four studies had a low overall risk of bias and only one trial with some concerns about selection bias. There was no difference between SC saline irrigation and no irrigation regarding the incidence of superficial SSI (five RCTs, RR: 0.72 with 95% CI [0.47, 1.10], P = 0.13), seroma (four RCTs, RR: 0.73 with 95% CI [0.32, 1.65], P = 0.45), wound separation (four RCTs, RR: 0.66 with 95% CI [0.36, 1.24], P = 0.2), and operative time (four RCTs, MD: -1.26 with 95% CI [-5.14, 2.62], P = 0.52). However, SC saline irrigation significantly decreased the incidence of hematoma (three RCTs, RR: 0.54 with 95% CI [0.45, 0.65], P = 0.00001). SC saline irrigation of the surgical site after CS was not effective in preventing the incidence of superficial SSI, seroma, or wound separation, while only preventing the incidence of hematoma.",
    "authors": [
        {
            "affiliation": "Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, EGY.",
            "firstname": "Wardah",
            "initials": "W",
            "lastname": "Albzea"
        },
        {
            "affiliation": "Obstetrics and Gynecology, Kuwait Institute for Medical Specializations, Kuwait City, KWT.",
            "firstname": "Lolwa",
            "initials": "L",
            "lastname": "Almonayea"
        },
        {
            "affiliation": "College of Medicine, Arabian Gulf University, Manama, BHR.",
            "firstname": "Mooza M",
            "initials": "MM",
            "lastname": "Alzayed"
        },
        {
            "affiliation": "College of Medicine, Arabian Gulf University, Manama, BHR.",
            "firstname": "Abdullah M",
            "initials": "AM",
            "lastname": "Alharran"
        },
        {
            "affiliation": "Obstetrics and Gynecology, Kuwait Institute for Medical Specializations, Kuwait City, KWT.",
            "firstname": "Hanaa F",
            "initials": "HF",
            "lastname": "Alrashidi"
        },
        {
            "affiliation": "Medicine and Surgery, Kuwait Institute for Medical Specializations, Kuwait City, KWT.",
            "firstname": "Sarah",
            "initials": "S",
            "lastname": "Alenezi"
        },
        {
            "affiliation": "Medicine and Surgery, Farwaniya Hospital, Ministry of Health, Kuwait City, KWT.",
            "firstname": "Hamdah",
            "initials": "H",
            "lastname": "Hadi"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024, Albzea et al.",
    "doi": "10.7759/cureus.62152",
    "journal": "Cureus",
    "keywords": [
        "cesarean section (cs)",
        "hematoma",
        "normal saline",
        "surgical site infection (ssi)",
        "systematic review and meta-analysis"
    ],
    "methods": null,
    "publication_date": "2024-06-12",
    "pubmed_id": "38863775\n22464076\n37260225\n36578852\n26849801\n24738117\n29894926\n33353558\n28690864\n25681239\n27676639\n33781348\n31643080\n31462531\n20925605\n24773788\n27816413\n28448203\n30756124\n28885421",
    "results": null,
    "title": "The Effect of Subcutaneous Saline Irrigation on Wound Complications After Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.",
    "xml": "<Element 'PubmedArticle' at 0x788505c90180>"
}