{
    "abstract": "We assessed the relationship of body weight time in target range (TTR) with composite kidney outcome in people with overweight/obesity and type 2 diabetes mellitus (T2DM).\nIncluded in this study were 3,601 participants with baseline estimated glomerular filtration rate (eGFR) \u226560 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial. Body weight TTR was defined as the proportion of time during the first 4 years that body weight was within the weight loss target (a weight loss of \u22657% from baseline). The primary outcome was composite kidney outcome, defined as eGFR decline \u226530% from baseline and to a level <60 mL/min/1.73 m2 at follow-up visit, or end-stage kidney disease.\nDuring a median follow-up of 8.0 years, 435 cases of composite kidney outcome were documented. Body weight TTR during the first 4 years was inversely associated with the subsequent risk of composite kidney outcome (per SD increment; adjusted hazard ratio [HR] 0.81; 95% CI 0.70-0.93). Accordingly, the adjusted HRs (95% CI) of composite kidney outcome were 1.00 (reference), 0.73 (0.54-1.00), 0.71 (0.52-0.99), and 0.54 (0.36-0.80) for participants with body weight TTR of 0%, >0% to <29.9%, 29.9% to <69.7%, and 69.7% to <100%, respectively. Similar results were found for a doubling of the urine albumin to creatinine ratio (secondary outcome).\nA higher body weight TTR, with a weight loss target of losing \u22657% of initial weight, was associated with a lower risk of kidney outcomes in participants with overweight/obesity and T2DM.",
    "authors": [
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.\nDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.\nInstitute of Biomedicine, Anhui Medical University, Hefei, China.",
            "firstname": "Cheng",
            "initials": "C",
            "lastname": "Zu"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Mengyi",
            "initials": "M",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.\nInstitute of Biomedicine, Anhui Medical University, Hefei, China.",
            "firstname": "Xinyue",
            "initials": "X",
            "lastname": "Su"
        },
        {
            "affiliation": "Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.\nInstitute of Biomedicine, Anhui Medical University, Hefei, China.",
            "firstname": "Yuanxiu",
            "initials": "Y",
            "lastname": "Wei"
        },
        {
            "affiliation": "Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.\nInstitute of Biomedicine, Anhui Medical University, Hefei, China.",
            "firstname": "Qiguo",
            "initials": "Q",
            "lastname": "Meng"
        },
        {
            "affiliation": "Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.\nInstitute of Biomedicine, Anhui Medical University, Hefei, China.",
            "firstname": "Chengzhang",
            "initials": "C",
            "lastname": "Liu"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Ziliang",
            "initials": "Z",
            "lastname": "Ye"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Xiaoqin",
            "initials": "X",
            "lastname": "Gan"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Yuanyuan",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Panpan",
            "initials": "P",
            "lastname": "He"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Chun",
            "initials": "C",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.",
            "firstname": "Fan Fan",
            "initials": "FF",
            "lastname": "Hou"
        },
        {
            "affiliation": "Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.\nDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.\nInstitute of Biomedicine, Anhui Medical University, Hefei, China.",
            "firstname": "Xianhui",
            "initials": "X",
            "lastname": "Qin"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024 by the American Diabetes Association.",
    "doi": "10.2337/dc23-1727",
    "journal": "Diabetes care",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-12-11",
    "pubmed_id": "38079259",
    "results": "During a median follow-up of 8.0 years, 435 cases of composite kidney outcome were documented. Body weight TTR during the first 4 years was inversely associated with the subsequent risk of composite kidney outcome (per SD increment; adjusted hazard ratio [HR] 0.81; 95% CI 0.70-0.93). Accordingly, the adjusted HRs (95% CI) of composite kidney outcome were 1.00 (reference), 0.73 (0.54-1.00), 0.71 (0.52-0.99), and 0.54 (0.36-0.80) for participants with body weight TTR of 0%, >0% to <29.9%, 29.9% to <69.7%, and 69.7% to <100%, respectively. Similar results were found for a doubling of the urine albumin to creatinine ratio (secondary outcome).",
    "title": "Association of Body Weight Time in Target Range With the Risk of Kidney Outcomes in Patients With Overweight/Obesity and Type 2 Diabetes Mellitus.",
    "xml": "<Element 'PubmedArticle' at 0x7885030d8860>"
}