{
    "abstract": "The outbreak of the coronavirus disease (COVID-19) has led to a major concern and caused a pandemic globally. The goal of this study was to clarify the clinical characteristics of recovery and death in patients with severe or critical COVID-19.\nIn this retrospective single-center study, clinical data were collected from 74 severe or critical COVID-19 patients in Wuhan Fourth Hospital between Jan. 25th and Feb. 26th, 2020. All patients were divided into a recovery group or a death group according to clinical outcomes, and the differences between the groups were compared.\nOf the 74 patients enrolled in the study, 48 (64.9%) were severe cases and 26 (35.1%) were critical cases. Sixty (81.1%) patients were recovered and 14 (18.9%) died. Compared with recovery patients, patients in the death group were older, and had higher incidences of hypertension, coronary disease and dyspnea at admission. Laboratory tests for lactate dehydrogenase, creatine kinase, myoglobin, brain natriuretic peptide and D-dimer indicated higher levels in the death group. The PaO\nElderly patients with comorbidities are at higher risk of severe COVID-19 or death. Patients with a low blood gas index and poor coagulation function at admission had a high mortality rate. For such patients, comprehensive treatment should be performed as soon as possible to improve the prognosis and reduce mortality.",
    "authors": [
        {
            "affiliation": "Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.",
            "firstname": "Junli",
            "initials": "J",
            "lastname": "Li"
        },
        {
            "affiliation": "Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China.",
            "firstname": "Ge",
            "initials": "G",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Otorhinolaryngology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
            "firstname": "Heping",
            "initials": "H",
            "lastname": "Yu"
        },
        {
            "affiliation": "Department of Thyroid and Breast Surgery, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
            "firstname": "Xiang",
            "initials": "X",
            "lastname": "Peng"
        },
        {
            "affiliation": "Department of Neurosurgery, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: luoywen@whu.edu.cn.",
            "firstname": "Yongwen",
            "initials": "Y",
            "lastname": "Luo"
        },
        {
            "affiliation": "Department of Thyroid and Breast Surgery, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: cca24@163.com.",
            "firstname": "Cheng'an",
            "initials": "C",
            "lastname": "Cao"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2020 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.amjms.2020.05.040\n10.1097/CM9.0000000000000744\n10.1016/j.jaut.2020.102433\n10.12834/VetIt.2173.11599.1\n10.1001/jama.2020.1585\n10.1056/NEJMoa2002032\n10.3760/cma.j.issn.2095-4352.2020.0006",
    "journal": "The American journal of the medical sciences",
    "keywords": [
        "COVID-19",
        "Clinical features",
        "Coronavirus",
        "SARS-CoV-2"
    ],
    "methods": null,
    "publication_date": "2020-07-13",
    "pubmed_id": "32653160\n31986264\n31978945\n31995857\n32214079\n31986261\n32036774\n32007145\n32044814\n32113704\n32056235\n32048818\n32094589\n32112884\n32109443\n32031570\n32109013\n32007143\n12384122",
    "results": "Of the 74 patients enrolled in the study, 48 (64.9%) were severe cases and 26 (35.1%) were critical cases. Sixty (81.1%) patients were recovered and 14 (18.9%) died. Compared with recovery patients, patients in the death group were older, and had higher incidences of hypertension, coronary disease and dyspnea at admission. Laboratory tests for lactate dehydrogenase, creatine kinase, myoglobin, brain natriuretic peptide and D-dimer indicated higher levels in the death group. The PaO",
    "title": "Clinical Characteristics and Outcomes of 74 Patients With Severe or Critical COVID-19.",
    "xml": "<Element 'PubmedArticle' at 0x788503cafa60>"
}