{
    "abstract": "Biliary duct reconstruction is one of the most challenging parts of liver transplantation and accounts for 40%-60% of complications. While current stent-based devices on the market show promising results in reducing complications, they are manufactured from permanent synthetic materials and require a second reintervention for their removal. This exposes the patients to other potential complications and increases healthcare costs. This study develops a fabrication technique to produce a bioabsorbable biliary stent based on silk fibroin. The process used a dip-coating procedure for silk fibroin that produced highly smooth monolayer tubular specimens without the use of any additional surfactants during removal. This process was combined with an electrospinning step to produce bilayer structures through the deposition of electrospun silk fibroin on the outer surface. The structures proved to have promising mechanical, morphological, and cytocompatibility properties for use in the field of biliary stenting. Furthermore, the technique investigated proved to be reproducible, achieving an important requirement for large-scale use even in the presence of a biomaterial derived from a natural source. These results show the possibility of obtaining a completely bioabsorbable internal biliary stent that does not require any second reintervention. This study can be the starting point for further investigations both in\u00a0vitro and in\u00a0vivo to assess the suitability of silk fibroin biliary stents for clinical applications.",
    "authors": [
        {
            "affiliation": "Biomechanics Research Centre (BioMEC), School of Engineering, College of Science and Engineering, Institute for Health Discovery and Innovation, University of Galway, Galway, Ireland.\nFibrothelium GmbH, Aachen, Germany.",
            "firstname": "Benedetta",
            "initials": "B",
            "lastname": "Isella"
        },
        {
            "affiliation": "Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.\nFaculty of Medicine, Institute for Laboratory Animal Science and Experimental Surgery, University of Aachen Medical Centre, RWTH Aachen University, Aachen, Germany.",
            "firstname": "Nourhan",
            "initials": "N",
            "lastname": "Hassan"
        },
        {
            "affiliation": "Fibrothelium GmbH, Aachen, Germany.",
            "firstname": "Aleksander",
            "initials": "A",
            "lastname": "Drinic"
        },
        {
            "affiliation": "Department of General, Visceral and Transplant Surgery, University Hospital RWTH Aachen, Aachen, Germany.",
            "firstname": "Roman M",
            "initials": "RM",
            "lastname": "Eickhoff"
        },
        {
            "affiliation": "Faculty of Medicine, Institute for Laboratory Animal Science and Experimental Surgery, University of Aachen Medical Centre, RWTH Aachen University, Aachen, Germany.\nDepartment of Plastic, Aesthetic, and Hand Surgery, St. Antonius Hospital Eschweiler, Eschweiler, Germany.",
            "firstname": "Nadja",
            "initials": "N",
            "lastname": "Kr\u00f6ger"
        },
        {
            "affiliation": "Biomechanics Research Centre (BioMEC), School of Engineering, College of Science and Engineering, Institute for Health Discovery and Innovation, University of Galway, Galway, Ireland.",
            "firstname": "Ted J",
            "initials": "TJ",
            "lastname": "Vaughan"
        },
        {
            "affiliation": "Fibrothelium GmbH, Aachen, Germany.",
            "firstname": "Alexander",
            "initials": "A",
            "lastname": "Kopp"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.",
    "doi": "10.1002/jbm.b.35499",
    "journal": "Journal of biomedical materials research. Part B, Applied biomaterials",
    "keywords": [
        "PureSilk",
        "biliary stent",
        "bioabsorbable",
        "implant",
        "silk fibroin"
    ],
    "methods": null,
    "publication_date": "2025-01-31",
    "pubmed_id": "39888215",
    "results": null,
    "title": "Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting.",
    "xml": "<Element 'PubmedArticle' at 0x788502dbec50>"
}