{
    "abstract": "An 11-year-old male Schnauzer dog was referred for investigation of cough and regurgitation of one month duration and gradual hyporexia for the previous five months. Complete blood count showed severe leukocytosis. On ventrodorsal and lateral thoracic radiographs a soft tissue mass was visible in the craniodorsal mediastinum. Endoscopy showed esophageal dilatation and an irregular, nodular, friable, exophytic mass in the thoracic esophagus, which was invasive, vascularized and had ulcerated areas. The mass occluded approximately 90% of the esophageal lumen. The mucosa in the orad portion of the thoracic esophagus was pale and the aborad portion was hyperemic (red) with hemorrhages. The mucosa of the cervical and abdominal esophagus was macroscopically unremarkeble. Multiple biopsies using endoscopic cup biopsy forceps were taken from the mass for histopathologic analysis and a percutaneous endoscopic gastrostomy was performed. Histopathologic analysis of the biopsy samples was inconclusive due to the marked necrosis. The poor clinical condition of the dog precluded a more invasive approach, and palliative and supportive treatment was continued. After 100 days of follow-up, clinical signs worsened, and that day the dog had a fatal cardiac arrest due to aspiration pneumonia and sepsis. Postmortem examination showed a multilobulated mass in the esophageal wall with infiltration into the overlying esophageal mucosa and pulmonary and renal metastases. Histological examination revealed a poorly differentiated sarcoma. On immunohistochemical examination, the neoplastic cells showed marked cytoplasmic staining for vimentin and Iba-1. The proliferative rate was approximately 30% by Ki-67. Histological and immunohistochemical examination revealed the esophageal mass to be a primary histiocytic sarcoma. Histiocytic sarcoma is an extremely rare primary esophageal neoplasm in humans, and so far, there is no description in dogs. To the best of the authors knowledge this is the first case of primary esophageal histiocytic sarcoma in dogs. The clinical information reported here should improve recognition and aid in diagnosis of future cases.",
    "authors": [
        {
            "affiliation": "Department of Animal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: anelisebt@yahoo.com.br.",
            "firstname": "Anelise Bonilla",
            "initials": "AB",
            "lastname": "Trindade-Gerardi"
        },
        {
            "affiliation": "Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.",
            "firstname": "Camila Alves",
            "initials": "CA",
            "lastname": "da Silveira"
        },
        {
            "affiliation": "Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.",
            "firstname": "Janyni",
            "initials": "J",
            "lastname": "Duz"
        },
        {
            "affiliation": "Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.",
            "firstname": "Isabella Teixeira Ca\u00e7apietra Pires",
            "initials": "ITCP",
            "lastname": "da Silva"
        },
        {
            "affiliation": "Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.",
            "firstname": "Tain\u00e3 Normanton",
            "initials": "TN",
            "lastname": "Guim"
        },
        {
            "affiliation": "Department of Veterinary Clinical Pathology(,) Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre(,) Brazil.",
            "firstname": "Saulo Petinatti",
            "initials": "SP",
            "lastname": "Pavarini"
        },
        {
            "affiliation": "Department of Animal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.",
            "firstname": "Cristiano",
            "initials": "C",
            "lastname": "Gomes"
        },
        {
            "affiliation": "Department of Animal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.",
            "firstname": "Daniel Guimar\u00e3es",
            "initials": "DG",
            "lastname": "Gerardi"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.tcam.2024.100856",
    "journal": "Topics in companion animal medicine",
    "keywords": [
        "Canine",
        "Esophagus",
        "Histiocytic tumors",
        "Metastases",
        "Sarcoma"
    ],
    "methods": null,
    "publication_date": "2024-02-12",
    "pubmed_id": "38342291",
    "results": null,
    "title": "First description of a primary esophageal histiocytic sarcoma in a dog.",
    "xml": "<Element 'PubmedArticle' at 0x78850515de90>"
}