{
    "abstract": "To investigate the efficacy of basic fibroblast growth factor (bFGF) combined with topical oxygen therapy for deep II degree burn wounds, by comparing the effects of bFGF combined with topical oxygen therapy and bFGF with routine therapy.\nFrom February 2004 to July 2009, 85 patients with deep II degree burn wounds (117 wounds) were enrolled and divided into 4 groups randomly according to different treatments. There was no significant difference in sex, age, disease course, wound size, and wound treatment size among 4 groups (P > 0.05). In group A, 18 patients (28 wounds) were treated routinely; in group B, 23 patients (30 wounds) were treated with routine methods and topical oxygen therapy; in group C, 19 patients (25 wounds) were treated with routine methods and bFGF therapy; and in group D, 25 patients (34 wounds) were treated with routine methods and bFGF/topical oxygen therapy. Topical oxygen therapy was administered to the wound for 90 minutes per day for 3 weeks. The bFGF therapy was applied everyday (150 U/cm2) for 3 weeks.\nAll cases were followed up 6-12 months (9 months on average). The wound healing times in groups A, B, C, and D were (27.3 +/- 6.6), (24.2 +/- 5.8), (22.2 +/- 6.8), and (18.2 +/- 4.8) days, respectively; showing significant difference between group A and group D (P < 0.05). The wound healing rates in groups A, B, C, and D were 67.8% +/- 12.1%, 85.1% +/- 7.5%, 89.2% +/- 8.3%, and 96.1% +/- 5.6%, respectively; showing significant differences between group A and groups B, C, D (P < 0.05). The therapic effective rates in groups A, B, C, and D were 75%, 90%, 92%, and 100%, respectively; showing significant difference between group A and group D (P < 0.05). The Vancouver scar scale scoring of group D 6 months after treatment was better than that of group A (P < 0.05).\nThe bFGF combined with topical oxygen therapy can enhance deep II degree burn wound healing. Furthermore, the therapy method is simple and convenient.",
    "authors": [
        {
            "affiliation": "Department of Burn and Plastic Surgery, Affiliated First Hospital, Zunyi Medical College, Zunyi Guizhou, P.R.China. nie9898@sina.com",
            "firstname": "Kaiyu",
            "initials": "K",
            "lastname": "Nie"
        },
        {
            "affiliation": null,
            "firstname": "Pengcheng",
            "initials": "P",
            "lastname": "Li"
        },
        {
            "affiliation": null,
            "firstname": "Xueqin",
            "initials": "X",
            "lastname": "Zeng"
        },
        {
            "affiliation": null,
            "firstname": "Guangfeng",
            "initials": "G",
            "lastname": "Sun"
        },
        {
            "affiliation": null,
            "firstname": "Wenhu",
            "initials": "W",
            "lastname": "Jin"
        },
        {
            "affiliation": null,
            "firstname": "Zairong",
            "initials": "Z",
            "lastname": "Wei"
        },
        {
            "affiliation": null,
            "firstname": "Bo",
            "initials": "B",
            "lastname": "Wang"
        },
        {
            "affiliation": null,
            "firstname": "Jianping",
            "initials": "J",
            "lastname": "Qi"
        },
        {
            "affiliation": null,
            "firstname": "Yuming",
            "initials": "Y",
            "lastname": "Wang"
        },
        {
            "affiliation": null,
            "firstname": "Dali",
            "initials": "D",
            "lastname": "Wang"
        }
    ],
    "conclusions": "The bFGF combined with topical oxygen therapy can enhance deep II degree burn wound healing. Furthermore, the therapy method is simple and convenient.",
    "copyrights": null,
    "doi": null,
    "journal": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
    "keywords": [],
    "methods": null,
    "publication_date": "2010-07-17",
    "pubmed_id": "20632489",
    "results": "All cases were followed up 6-12 months (9 months on average). The wound healing times in groups A, B, C, and D were (27.3 +/- 6.6), (24.2 +/- 5.8), (22.2 +/- 6.8), and (18.2 +/- 4.8) days, respectively; showing significant difference between group A and group D (P < 0.05). The wound healing rates in groups A, B, C, and D were 67.8% +/- 12.1%, 85.1% +/- 7.5%, 89.2% +/- 8.3%, and 96.1% +/- 5.6%, respectively; showing significant differences between group A and groups B, C, D (P < 0.05). The therapic effective rates in groups A, B, C, and D were 75%, 90%, 92%, and 100%, respectively; showing significant difference between group A and group D (P < 0.05). The Vancouver scar scale scoring of group D 6 months after treatment was better than that of group A (P < 0.05).",
    "title": "[Clinical observation of basic fibroblast growth factor combined with topical oxygen therapy in enhancing burn wound healing].",
    "xml": "<Element 'PubmedArticle' at 0x788502ddbba0>"
}