{
    "abstract": "Programmed cell death protein-1 (PD-1) blockade has improved survival for patients with esophageal squamous cell carcinoma (ESCC), but response rates are low. Biomarkers to predict who will benefit from PD-1 blockade are urgently needed.\nThis multicenter study involved 250 patients with recurrent/unresectable advanced ESCC receiving nivolumab as second- or later-line therapy. We assessed tumor-infiltrating T lymphocytes (TILs) and tertiary lymphoid structure (TLS) density using immunohistochemistry and hematoxylin/eosin staining in surgical specimens and pre-nivolumab endoscopic biopsies.\nIn surgical specimens, clinical response (vs. non-response) to nivolumab correlated significantly with CD8\nCD8",
    "authors": [
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Shigeto",
            "initials": "S",
            "lastname": "Nakai"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan. tmakino@gesurg.med.osaka-u.ac.jp.",
            "firstname": "Tomoki",
            "initials": "T",
            "lastname": "Makino"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Kota",
            "initials": "K",
            "lastname": "Momose"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Kotaro",
            "initials": "K",
            "lastname": "Yamashita"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Koji",
            "initials": "K",
            "lastname": "Tanaka"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.",
            "firstname": "Hiroshi",
            "initials": "H",
            "lastname": "Miyata"
        },
        {
            "affiliation": "Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.",
            "firstname": "Sachiko",
            "initials": "S",
            "lastname": "Yamamoto"
        },
        {
            "affiliation": "Department of Surgery, Osaka General Medical Center, Osaka, Japan.",
            "firstname": "Masaaki",
            "initials": "M",
            "lastname": "Motoori"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Kindai University Nara Hospital, Nara, Japan.",
            "firstname": "Yutaka",
            "initials": "Y",
            "lastname": "Kimura"
        },
        {
            "affiliation": "Department of Surgery, Sakai City Medical Center, Osaka, Japan.",
            "firstname": "Ryohei",
            "initials": "R",
            "lastname": "Kawabata"
        },
        {
            "affiliation": "Department of Surgery, NHO Osaka National Hospital, Osaka, Japan.",
            "firstname": "Motohiro",
            "initials": "M",
            "lastname": "Hirao"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Osaka, Japan.",
            "firstname": "Jin",
            "initials": "J",
            "lastname": "Matsuyama"
        },
        {
            "affiliation": "Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.",
            "firstname": "Yusuke",
            "initials": "Y",
            "lastname": "Akamaru"
        },
        {
            "affiliation": "Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.",
            "firstname": "Hitomi",
            "initials": "H",
            "lastname": "Morihara"
        },
        {
            "affiliation": "Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.",
            "firstname": "Azumi",
            "initials": "A",
            "lastname": "Ueyama"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Yukinori",
            "initials": "Y",
            "lastname": "Kurokawa"
        },
        {
            "affiliation": "Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan.",
            "firstname": "Eiichi",
            "initials": "E",
            "lastname": "Morii"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.\nDepartment of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.",
            "firstname": "Hisashi",
            "initials": "H",
            "lastname": "Wada"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Hidetoshi",
            "initials": "H",
            "lastname": "Eguchi"
        },
        {
            "affiliation": "Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.",
            "firstname": "Yuichiro",
            "initials": "Y",
            "lastname": "Doki"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1007/s10388-025-01120-z\n10.1002/ags3.12685\n10.1002/ags3.12657\n10.3322/caac.21492\n10.1053/j.gastro.2017.08.023\n10.1007/s10388-022-00950-5\n10.1038/nrdp.2017.48\n10.1038/s41416-022-01726-5\n10.1038/s41416-023-02151-y\n10.1097/SLA.0000000000002808\n10.1097/SLA.0000000000003129\n10.1038/sj.bjc.6605313\n10.1038/sj.bjc.6606071\n10.1111/cas.12486\n10.1158/2326-6066.CIR-14-0040\n10.1200/JCO.2009.26.7609\n10.1016/S1470-2045(19)30626-6\n10.1097/SLA.0000000000005104\n10.1111/cas.14328\n10.1038/nrc.2016.36\n10.1126/science.1129139\n10.1038/nrc3245\n10.1029/2004GL021533\n10.1038/s41416-023-02235-9\n10.1097/SLA.0000000000003445\n10.1007/s10388-024-01056-w\n10.1293/tox.2019-0022\n10.3390/cancers14071740\n10.1038/s41379-022-01139-y\n10.1186/s12916-021-02148-5\n10.1038/s41416-018-0220-9\n10.1038/nature13954\n10.1016/j.jtho.2021.04.016\n10.3389/fonc.2021.658690\n10.1038/s41467-021-25962-0\n10.1073/pnas.1822001116\n10.1038/s41598-022-09458-5\n10.4049/jimmunol.177.10.6940\n10.1038/nm1093\n10.1200/JCO.2006.05.9584\n10.1002/cncr.11618\n10.1038/s41379-018-0142-3\n10.1038/s41590-020-0769-3\n10.1111/cas.13785\n10.1038/s41467-019-12160-2\n10.1080/2162402X.2016.1257452\n10.1038/s41586-019-1914-8\n10.3892/ol.2020.11828\n10.1136/jitc-2021-003984\n10.21873/anticanres.13631",
    "journal": "Esophagus : official journal of the Japan Esophageal Society",
    "keywords": [
        "Anti-PD-1 antibody",
        "Biomarker",
        "Esophageal squamous cell carcinoma",
        "Tertiary lymphoid structure",
        "Tumor-infiltrating T lymphocytes"
    ],
    "methods": null,
    "publication_date": "2025-04-25",
    "pubmed_id": "40274705\n37416735\n30207593\n28823862\n36152081\n28748917\n35140339\n36841907\n29727327\n30829694\n19755983\n21206495\n25041052\n24872026\n20516446\n31582355\n31981293\n27079802\n17008531\n22419253\n37016103\n31274656\n38717686\n31719761\n35406511\n35915139\n34802443\n30318514\n25428505\n33975004\n34150625\n34580291\n31028147\n35354899\n17082609\n15322536\n17135638\n12942579\n30297881\n32868929\n30156356\n31519915\n28197375\n31942071\n32782582\n35361730\n31366557",
    "results": "In surgical specimens, clinical response (vs. non-response) to nivolumab correlated significantly with CD8",
    "title": "Exploring predictive biomarkers of efficacy and survival with nivolumab treatment for unresectable/recurrent esophageal squamous cell carcinoma.",
    "xml": "<Element 'PubmedArticle' at 0x78850555aca0>"
}