{
    "abstract": "As a surgical option for osteochondral lesions of the talus, autologous matrix-induced chondrogenesis (AMIC\nTwo patients underwent revision surgery (14 and 36 months after the index AMIC\nDuring the revision arthroscopy, the regenerated cartilage was the same color but softer than the surrounding cartilage, superficially frayed, without fissures and even with the level of the original cartilage, but not completely stable on the subchondral bone. Histology revealed the presence of Safranin-O-positive fibrocartilage-like tissue. Additionally, cartilaginous-like tissue was found in the 36-month biopsy. IHC revealed a fraction of collagen type II positive cells in the fibrocartilage-like tissue as well as a collagen type II positive extracellular matrix. The cartilaginous tissue of the 36-month biopsy revealed a homogeneous collagen type II stain.\nThe presence of collagen type II within the tissue indicates its transformation into hyaline-like cartilage at 14 months after AMIC",
    "authors": [
        {
            "affiliation": "Orthopaedic Surgery and Traumatology, Klinik Sonnenhof, Bern, Switzerland. fabiankrause@sonnenhof.ch.",
            "firstname": "Fabian",
            "initials": "F",
            "lastname": "Krause"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, Inselspital, University of Berne, Freiburgstrasse, Berne, Switzerland.",
            "firstname": "Helen",
            "initials": "H",
            "lastname": "Anwander"
        },
        {
            "affiliation": "Geistlich Pharma, AG, Wolhusen, Switzerland.",
            "firstname": "Birgit",
            "initials": "B",
            "lastname": "Sch\u00e4fer"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9The Author(s) 2025. Open Access. This article is licensed under a Creative Commons CC-BY International License.",
    "doi": "10.14670/HH-18-919",
    "journal": "Histology and histopathology",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-04-28",
    "pubmed_id": "40289876",
    "results": "During the revision arthroscopy, the regenerated cartilage was the same color but softer than the surrounding cartilage, superficially frayed, without fissures and even with the level of the original cartilage, but not completely stable on the subchondral bone. Histology revealed the presence of Safranin-O-positive fibrocartilage-like tissue. Additionally, cartilaginous-like tissue was found in the 36-month biopsy. IHC revealed a fraction of collagen type II positive cells in the fibrocartilage-like tissue as well as a collagen type II positive extracellular matrix. The cartilaginous tissue of the 36-month biopsy revealed a homogeneous collagen type II stain.",
    "title": "Immunohistochemical evidence for hyaline-like cartilage formation after autologous matrix-induced chondrogenesis for osteochondral lesions of the talus: Case reports of 2 patients.",
    "xml": "<Element 'PubmedArticle' at 0x788504fde390>"
}