{
    "abstract": "To assess whether and to what extent excess risk of all-cause death is reduced in individuals with type 2 diabetes by achieving optimal control of traditional cardiovascular risk factors.\nThis observational, prospective, cohort study enrolled 15,773 Caucasian patients in 19 Italian centres in 2006-2008. Participants were stratified according to the number of the following risk factors outside target: haemoglobin A\nAge-adjusted mortality rates and hazard ratios were significantly higher in the whole RIACE cohort (by \u223c20 %) and in patients with (by \u223c100 %) but not in those without prior cardiovascular disease (CVD), as compared with the coeval Italian general population. In all patients and in those without prior CVD, the relationship with mortality according to the number of risk factors outside target was J-shaped, an effect that was attenuated after either excluding \"overtreated \" patients, i.e., those with haemoglobin A\nIn patients with type 2 diabetes, optimal treatment of traditional cardiovascular risk factors completely eliminated the excess mortality risk versus the general population, provided that they were not \"overtreated\". However, this effect was observed only in participants without history of CVD.\nClinicalTrials.gov, NCT00715481, retrospectively registered 15 July 2008.",
    "authors": [
        {
            "affiliation": "Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.",
            "firstname": "Monia",
            "initials": "M",
            "lastname": "Garofolo"
        },
        {
            "affiliation": "Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.",
            "firstname": "Giuseppe",
            "initials": "G",
            "lastname": "Penno"
        },
        {
            "affiliation": "Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Solini"
        },
        {
            "affiliation": "Diabetes Unit, Fondazione IRCCS \"C\u00e0 Granda - Ospedale Maggiore Policlinico\", Milan, Italy.",
            "firstname": "Emanuela",
            "initials": "E",
            "lastname": "Orsi"
        },
        {
            "affiliation": "Department of Clinical and Molecular Medicine, \"La Sapienza\" University, Rome, Italy.",
            "firstname": "Martina",
            "initials": "M",
            "lastname": "Vitale"
        },
        {
            "affiliation": "Diabetes Unit, Fondazione IRCCS \"C\u00e0 Granda - Ospedale Maggiore Policlinico\", Milan, Italy.",
            "firstname": "Veronica",
            "initials": "V",
            "lastname": "Resi"
        },
        {
            "affiliation": "Division of Endocrinology, Diabetes and Metabolism, University and Hospital Trust of Verona, Verona, Italy.",
            "firstname": "Enzo",
            "initials": "E",
            "lastname": "Bonora"
        },
        {
            "affiliation": "Diabetes Unit, University of Siena, Siena, Italy.",
            "firstname": "Cecilia",
            "initials": "C",
            "lastname": "Fondelli"
        },
        {
            "affiliation": "Endocrinology and Diabetes Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.",
            "firstname": "Roberto",
            "initials": "R",
            "lastname": "Trevisan"
        },
        {
            "affiliation": "Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy.",
            "firstname": "Monica",
            "initials": "M",
            "lastname": "Vedovato"
        },
        {
            "affiliation": "Centre for Outcomes Research and Clinical Epidemiology (CORESEARCH), Pescara, Italy.",
            "firstname": "Antonio",
            "initials": "A",
            "lastname": "Nicolucci"
        },
        {
            "affiliation": "Department of Clinical and Molecular Medicine, \"La Sapienza\" University, Rome, Italy. Electronic address: giuseppe.pugliese@uniroma1.it.",
            "firstname": "Giuseppe",
            "initials": "G",
            "lastname": "Pugliese"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 The Author(s). Published by Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.ejim.2024.05.034",
    "journal": "European journal of internal medicine",
    "keywords": [
        "All-cause mortality",
        "Cardiovascular disease",
        "Cardiovascular risk factors",
        "Treatment",
        "Type 2 diabetes"
    ],
    "methods": null,
    "publication_date": "2024-06-07",
    "pubmed_id": "38845288",
    "results": "Age-adjusted mortality rates and hazard ratios were significantly higher in the whole RIACE cohort (by \u223c20 %) and in patients with (by \u223c100 %) but not in those without prior cardiovascular disease (CVD), as compared with the coeval Italian general population. In all patients and in those without prior CVD, the relationship with mortality according to the number of risk factors outside target was J-shaped, an effect that was attenuated after either excluding \"overtreated \" patients, i.e., those with haemoglobin A",
    "title": "Relationship between degree of risk factor control and all-cause mortality in individuals with type 2 diabetes: A prospective cohort study.",
    "xml": "<Element 'PubmedArticle' at 0x788504c223e0>"
}