{
    "abstract": "IAs location distribution in patients with ADPKD differ from the ones in non-ADPKD patients. IAs in patients with ADPKD are more commonly located in the anterior circulation and in large caliber arteries. Because of IA multiplicity and singular IA distribution, patients with ADPKD represent a special population who need to be closely followed.\nAutosomal dominant polycystic kidney disease (ADPKD) is the most common genetic condition associated with intracranial aneurysms (IAs). The associated pathophysiology remains unknown, but an association with wall shear stress is suspected. Cerebral arterial location is the principal factor influencing IA natural history. This study aims to compare IA location-specific distribution between ADPKD and non-ADPKD patients.\nThe ADPKD group comprised data from a systematic review of the literature (2016\u20132020, \nA total of 1184 IAs from patients with ADPKD were compared with 21,040 IAs from non-ADPKD patients. In total, 78.6% of patients with ADPKD had hypertension versus 39.2% of non-ADPKD patients. A total of 32.4% of patients with ADPKD were smokers versus 31.5% of non-ADPKD patients. In total, 30.1% of patients with ADPKD had a positive family history for IA versus 15.8% of the non-ADPKD patients. Patients with ADPKD showed a higher rate of IA multiplicity (33.2% versus 23.1%). IAs from patients with ADPKD showed a significant predominance across the internal carotid and middle cerebral arteries. Posterior communicating IAs were more frequently found in the non-ADPKD group. The meta-analysis confirmed a predominance of IAs in the patients with ADPKD across large caliber arteries (odds ratio [95% confidence interval]: internal carotid artery: 1.90 [1.10 to 3.29]; middle cerebral artery: 1.18 [1.02\u20131.36]). Small diameter arteries, such as the posterior communicating, were observed more in non-ADPKD patients (0.21 [0.11\u20130.88]).\nThis analysis shows that IAs diagnosed in patients with ADPKD are more often localized in large caliber arteries from the anterior circulation in comparison with IAs in non-ADPKD patients. It shows that primary cilia driven wall shear stress vessel remodeling to be more critical in cerebral anterior circulation large caliber arteries.",
    "authors": [
        {
            "affiliation": "Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.",
            "firstname": "Julien",
            "initials": "J",
            "lastname": "Haemmerli"
        },
        {
            "affiliation": "Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.\nDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.",
            "firstname": "Sandrine",
            "initials": "S",
            "lastname": "Morel"
        },
        {
            "affiliation": "Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.",
            "firstname": "Marc",
            "initials": "M",
            "lastname": "Georges"
        },
        {
            "affiliation": "Division of Nephrology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.\nDivision of Transplantation, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.",
            "firstname": "Fadi",
            "initials": "F",
            "lastname": "Haidar"
        },
        {
            "affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.",
            "firstname": "Fouad T",
            "initials": "FT",
            "lastname": "Chebib"
        },
        {
            "affiliation": "Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan.",
            "firstname": "Akio",
            "initials": "A",
            "lastname": "Morita"
        },
        {
            "affiliation": "Department of Neurosurgery, Shiga University of Medical Science, Otsu, Japan.",
            "firstname": "Kazuhiko",
            "initials": "K",
            "lastname": "Nozaki"
        },
        {
            "affiliation": "Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.",
            "firstname": "Teiji",
            "initials": "T",
            "lastname": "Tominaga"
        },
        {
            "affiliation": "The \"Federal Centre of Neurosurgery\" of the Ministry of Health of the Russian Federation Novosibirsk, Novosibirsk Region, Novosibirsk, Russia.",
            "firstname": "Anatoliy V",
            "initials": "AV",
            "lastname": "Bervitskiy"
        },
        {
            "affiliation": "The \"Federal Centre of Neurosurgery\" of the Ministry of Health of the Russian Federation Novosibirsk, Novosibirsk Region, Novosibirsk, Russia.",
            "firstname": "Jamil",
            "initials": "J",
            "lastname": "Rzaev"
        },
        {
            "affiliation": "Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.",
            "firstname": "Karl",
            "initials": "K",
            "lastname": "Schaller"
        },
        {
            "affiliation": "Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.",
            "firstname": "Philippe",
            "initials": "P",
            "lastname": "Bijlenga"
        }
    ],
    "conclusions": "This analysis shows that IAs diagnosed in patients with ADPKD are more often localized in large caliber arteries from the anterior circulation in comparison with IAs in non-ADPKD patients. It shows that primary cilia driven wall shear stress vessel remodeling to be more critical in cerebral anterior circulation large caliber arteries.",
    "copyrights": null,
    "doi": "10.34067/KID.0000000000000092\n10.1093/neuros/nyy551\n10.1038/nrneph.2015.128\n10.1038/nrneurol.2017.14\n10.1007/s00701-017-3142-z\n10.1212/wnl.0000000000004597\n10.1016/j.jocn.2019.07.048\n10.1007/s00701-019-04060-7\n10.1016/s0140-6736(18)32782-x\n10.1016/j.pjnns.2017.08.007\n10.1007/s00701-017-3316-8\n10.2215/CJN.14691218\n10.1093/jnen/nly031\n10.1073/pnas.040550097\n10.1007/s10143-021-01554-w\n10.3174/ajnr.a3558\n10.1111/eci.12992\n10.1161/strokeaha.114.008198\n10.1056/nejmoa1113260\n10.1056/NEJM199812103392401\n10.1136/jnnp-2020-324371\n10.3390/jpm12091410\n10.1007/s10237-016-0804-3\n10.1177/1591019918754380\n10.1016/j.clineuro.2009.12.018\n10.3171/2017.5.jns17195\n10.1371/journal.pmed.1000097\n10.1161/strokeaha.117.017391\n10.1037/1082-989x.11.2.193\n10.1016/j.jclinepi.2011.03.017\n10.1093/neuros/nyy336\n10.3174/ajnr.a3437\n10.1159/000342620\n10.1007/s00415-003-0997-0\n10.3174/ajnr.a4490\n10.3171/2019.4.focus19145\n10.1007/s00234-018-2135-9\n10.3171/2019.5.focus19234\n10.1227/neu.0000000000001083\n10.1159/000368475\n10.1093/cvr/cvab165\n10.2215/CJN.02100219\n10.1161/strokeaha.110.578740\n10.1016/j.kint.2017.08.016\n10.1093/icvts/ivy163\n10.12659/pjr.894482",
    "journal": "Kidney360",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-03-25",
    "pubmed_id": "36961086\n30476226\n26260542\n28145447\n28283868\n28978659\n31371190\n31502043\n30819518\n28843770\n28884237\n31362991\n29688417\n10677526\n33913050\n23598838\n29962043\n25757900\n22738097\n9867550\n33097563\n36143196\n27440126\n29444617\n20096503\n29099302\n19621072\n28667020\n16784338\n21803546\n30060240\n23292526\n23139683\n12700905\n26338918\n31261120\n30456458\n31261126\n26516819\n25571876\n33974072\n31217168\n21164130\n29061331\n29868857\n27733888",
    "results": "A total of 1184 IAs from patients with ADPKD were compared with 21,040 IAs from non-ADPKD patients. In total, 78.6% of patients with ADPKD had hypertension versus 39.2% of non-ADPKD patients. A total of 32.4% of patients with ADPKD were smokers versus 31.5% of non-ADPKD patients. In total, 30.1% of patients with ADPKD had a positive family history for IA versus 15.8% of the non-ADPKD patients. Patients with ADPKD showed a higher rate of IA multiplicity (33.2% versus 23.1%). IAs from patients with ADPKD showed a significant predominance across the internal carotid and middle cerebral arteries. Posterior communicating IAs were more frequently found in the non-ADPKD group. The meta-analysis confirmed a predominance of IAs in the patients with ADPKD across large caliber arteries (odds ratio [95% confidence interval]: internal carotid artery: 1.90 [1.10 to 3.29]; middle cerebral artery: 1.18 [1.02\u20131.36]). Small diameter arteries, such as the posterior communicating, were observed more in non-ADPKD patients (0.21 [0.11\u20130.88]).",
    "title": "Characteristics and Distribution of Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease Compared with the General Population: A Meta-Analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788503f541d0>"
}