{
    "abstract": "Failure of orthopedic implants due to localized bacterial infections, inflammation and insufficient blood supply is always problematic. In this study, strontium-doped titanium dioxide nanotubes (STN) were firstly prepared on titanium surface, and then lactoferrin (LF) was loaded into strontium-doped nanotubes (STN) by the phase transition method, eventually the LF/TCEP-STN composite coating was successfully prepared. With the innate antimicrobial properties of LF, LF/TCEP-STN was effected against E. coli and S. aureus. Cellular assays showed that RAW264.7 (immune), HUVEC (angiogenic) and MC3T3-E1 (osteogenic) exhibited good adhesion and proliferative activity on the surface of LF/TCEP-STN. At the molecular level, LF/TCEP-STN modulated RAW264.7 polarization toward M2-type while promoting MC3T3-E1 differentiation toward osteogenesis. Meanwhile LF/TCEP-STN coating effectively promoted angiogenesis. The results of the bone defect model with or without infection demonstrated that the LF/TCEP-STN material had good anti-inflammatory, antibacterial, and vascularization-promoting osteogenesis. In addition, LF/TCEP-STN offered excellent blood compatibility and biosafety. As a multifunctional coating on implant surfaces, the study's results highlighted the viability of LF/TCEP-STN and offered fresh concepts for the clinical design of next-generation artificial bone implants with antibacterial, anti-inflammatory, and osteogenic properties.",
    "authors": [
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China.",
            "firstname": "Jiali",
            "initials": "J",
            "lastname": "Wang"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China.",
            "firstname": "Jiaxin",
            "initials": "J",
            "lastname": "Guan"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China.",
            "firstname": "Fengzhen",
            "initials": "F",
            "lastname": "Jia"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China.",
            "firstname": "Zitong",
            "initials": "Z",
            "lastname": "Tian"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China.",
            "firstname": "Lili",
            "initials": "L",
            "lastname": "Song"
        },
        {
            "affiliation": "School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.",
            "firstname": "Lei",
            "initials": "L",
            "lastname": "Xie"
        },
        {
            "affiliation": "School of Materials Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, China.",
            "firstname": "Pengde",
            "initials": "P",
            "lastname": "Han"
        },
        {
            "affiliation": "School of Chemistry and Materials Science, Ludong University, Yantai 264025, China.",
            "firstname": "He",
            "initials": "H",
            "lastname": "Lin"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China. Electronic address: haixiaqiao@yeah.net.",
            "firstname": "Haixia",
            "initials": "H",
            "lastname": "Qiao"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China. Electronic address: 527238610@qq.com.",
            "firstname": "Xuejiao",
            "initials": "X",
            "lastname": "Zhang"
        },
        {
            "affiliation": "College of Lab Medicine, Life Science Research Centre, Hebei North University, Zhangjiakou 075000, China. Electronic address: hycd08@126.com.",
            "firstname": "Yong",
            "initials": "Y",
            "lastname": "Huang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.ijbiomac.2024.138608",
    "journal": "International journal of biological macromolecules",
    "keywords": [
        "Anti-inflammatory",
        "Antibacterial",
        "Lactoferrin",
        "Osteogenesis",
        "SrTiO(3)",
        "Vascularization"
    ],
    "methods": null,
    "publication_date": "2024-12-12",
    "pubmed_id": "39662560",
    "results": null,
    "title": "Phase-transformed lactoferrin/strontium-doped nanocoatings enhance antibacterial, anti-inflammatory and vascularised osteogenesis of titanium.",
    "xml": "<Element 'PubmedArticle' at 0x7885036446d0>"
}