{
    "abstract": "Our previous research revealed that daphnetin (7,8-dihydroxycou-marin) positively influences the balance between forked transcription factor P3 (\nMice (n = 40) were allocated into the following groups: daphnetin high dose (4 mg/kg\u00b7day), daphnetin low dose (1 mg/kg\u00b7day), URSA model, and normal pregnancy (control). We used flow cytometry for assessing the Th17/Treg cell ratio in peripheral blood mononuclear cells, quantitative real-time polymerase chain reaction for measuring cytokine expression levels, and transmission electron microscopy for observing ultrastructural changes in decidual tissues and calculating the embryo absorption rate.\nCompared to the URSA model group, daphnetin significantly reduced the T17cell/\nDaphnetin improves the Th17 cell/",
    "authors": [
        {
            "affiliation": "Department of Gynecological Oncology, Jiangxi Maternity and Child Healthcare Hospital, 330006 Nanchang, Jiangxi, China.",
            "firstname": "Sheng-Gen",
            "initials": "SG",
            "lastname": "Long"
        },
        {
            "affiliation": "Department of Reproductive Center, Jiangxi Maternity and Child Healthcare Hospital, 330006 Nanchang, Jiangxi, China.",
            "firstname": "Zhi-Qin",
            "initials": "ZQ",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Reproductive Center, Jiangxi Maternity and Child Healthcare Hospital, 330006 Nanchang, Jiangxi, China.",
            "firstname": "Jun",
            "initials": "J",
            "lastname": "Tan"
        }
    ],
    "conclusions": "Daphnetin improves the Th17 cell/",
    "copyrights": null,
    "doi": "10.24976/Discov.Med.202436190.199",
    "journal": "Discovery medicine",
    "keywords": [
        "T cells",
        "cytokine",
        "daphnetin",
        "immune regulation",
        "unexplained recurrent spontaneous abortion"
    ],
    "methods": null,
    "publication_date": "2024-11-27",
    "pubmed_id": "39600272",
    "results": "Compared to the URSA model group, daphnetin significantly reduced the T17cell/",
    "title": "Daphnetin Modulates Immune Balance and Enhances Pregnancy Viability in a Mouse Model of Unexplained Recurrent Abortion.",
    "xml": "<Element 'PubmedArticle' at 0x7885031a8590>"
}