{
    "abstract": "Some studies have reported the early miscarriage rate is higher in polycystic ovary syndrome (PCOS) women. However, there is a lack of evidence as to whether the risk of embryo abnormalities increases in PCOS women.\nThis work aimed to evaluate the association between PCOS and embryo ploidy.\nA secondary analysis of a multicenter, randomized controlled trial was conducted from July 2017 to June 2018. The original intent was to identify whether preimplantation genetic test for aneuploidy (PGT-A) improves the live birth rate as compared with in vitro fertilization (IVF). From 14 reproductive centers, 190 patients diagnosed with PCOS and 1:1 age-matched non-PCOS patients were chosen from a PGT-A group. A total of 380 patients with 1118 embryos were included in our study. Intervention included women diagnosed with PCOS, and the main outcome measures were embryonic aneuploidy and embryonic mosaic.\nAfter adjusting for potential confounders, the rate of embryonic aneuploidy and embryonic mosaic in the PCOS group were comparable with the control group (embryonic aneuploid rate PCOS group: 14.0% vs control group: 18.3%, adjusted OR [95% CI]: 0.78 [0.54, 1.12]; P = .19; embryonic mosaic rate 10.9% vs 10.1%, adjusted OR [95% CI]: 0.91 [0.59, 1.40]; P = .66). We further stratified PCOS women into 4 groups according to phenotype. The rate of aneuploid and mosaic embryos was comparable between each PCOS phenotype and control group. There was still no significant difference of embryonic aneuploid and embryo mosaic rates among the 4 phenotypes.\nThe risk of aneuploid and mosaic embryos did not increase in PCOS women. Thus, we suggest that the miscarriage rate arising from abnormal embryonic chromosomes could be similar between PCOS and non-PCOS women.",
    "authors": [
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.",
            "firstname": "Jiahui",
            "initials": "J",
            "lastname": "Wang"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.",
            "firstname": "Zhiyi",
            "initials": "Z",
            "lastname": "Song"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.",
            "firstname": "Tianxiang",
            "initials": "T",
            "lastname": "Ni"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.",
            "firstname": "Qian",
            "initials": "Q",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.\nShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China.\nCenter for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.",
            "firstname": "Zi-Jiang",
            "initials": "ZJ",
            "lastname": "Chen"
        },
        {
            "affiliation": "Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.\nKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, Shandong, China.\nShandong Key Laboratory of Reproductive Medicine, Jinan 250012, Shandong, China.\nShandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, Shandong, China.\nShandong Technology Innovation Center for Reproductive Health, Jinan 250012, Shandong, China.\nNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, Shandong, China.",
            "firstname": "Junhao",
            "initials": "J",
            "lastname": "Yan"
        }
    ],
    "conclusions": "The risk of aneuploid and mosaic embryos did not increase in PCOS women. Thus, we suggest that the miscarriage rate arising from abnormal embryonic chromosomes could be similar between PCOS and non-PCOS women.",
    "copyrights": "\u00a9 The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
    "doi": "10.1210/clinem/dgac726",
    "journal": "The Journal of clinical endocrinology and metabolism",
    "keywords": [
        "aneuploidy",
        "mosaic",
        "phenotype",
        "polycystic ovarian syndrome",
        "preimplantation genetic test for aneuploidy"
    ],
    "methods": null,
    "publication_date": "2022-12-23",
    "pubmed_id": "36546342",
    "results": "After adjusting for potential confounders, the rate of embryonic aneuploidy and embryonic mosaic in the PCOS group were comparable with the control group (embryonic aneuploid rate PCOS group: 14.0% vs control group: 18.3%, adjusted OR [95% CI]: 0.78 [0.54, 1.12]; P = .19; embryonic mosaic rate 10.9% vs 10.1%, adjusted OR [95% CI]: 0.91 [0.59, 1.40]; P = .66). We further stratified PCOS women into 4 groups according to phenotype. The rate of aneuploid and mosaic embryos was comparable between each PCOS phenotype and control group. There was still no significant difference of embryonic aneuploid and embryo mosaic rates among the 4 phenotypes.",
    "title": "Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial.",
    "xml": "<Element 'PubmedArticle' at 0x7885068824d0>"
}