{
    "abstract": "Metformin is the most widely prescribed oral antiglycemic drug, with few adverse effects. However, surprisingly little is known about its human biodistribution and target tissue metabolism. In animal experiments, we have shown that metformin can be labeled by \nNine subjects (3 women and 6 men) participated in 2 studies: in the first study, human radiation dosimetry and biodistribution of \nRadiation dosimetry was acceptable, with effective doses of 9.5 \u03bcSv/MBq (intravenous administration) and 18.1 \u03bcSv/MBq (oral administration). Whole-body PET revealed that ",
    "authors": [
        {
            "affiliation": "Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark lars.christian.gormsen@clin.au.dk.",
            "firstname": "Lars C",
            "initials": "LC",
            "lastname": "Gormsen"
        },
        {
            "affiliation": "Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "Elias Immanuel",
            "initials": "EI",
            "lastname": "Sundelin"
        },
        {
            "affiliation": "Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark.\nDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "Jonas Brorson",
            "initials": "JB",
            "lastname": "Jensen"
        },
        {
            "affiliation": "Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "Mikkel Holm",
            "initials": "MH",
            "lastname": "Vendelbo"
        },
        {
            "affiliation": "Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "Steen",
            "initials": "S",
            "lastname": "Jakobsen"
        },
        {
            "affiliation": "Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "Ole Lajord",
            "initials": "OL",
            "lastname": "Munk"
        },
        {
            "affiliation": "Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.",
            "firstname": "Mette Marie",
            "initials": "MM",
            "lastname": "Hougaard Christensen"
        },
        {
            "affiliation": "Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.\nDepartment of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark; and.",
            "firstname": "Kim",
            "initials": "K",
            "lastname": "Br\u00f8sen"
        },
        {
            "affiliation": "Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "J\u00f8rgen",
            "initials": "J",
            "lastname": "Fr\u00f8ki\u00e6r"
        },
        {
            "affiliation": "Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.\nDepartment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.",
            "firstname": "Niels",
            "initials": "N",
            "lastname": "Jessen"
        }
    ],
    "conclusions": "",
    "copyrights": "\u00a9 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",
    "doi": "10.2967/jnumed.116.177774",
    "journal": "Journal of nuclear medicine : official publication, Society of Nuclear Medicine",
    "keywords": [
        "11C-metformin",
        "PET/CT",
        "biodistribution",
        "metformin"
    ],
    "methods": null,
    "publication_date": "2016-07-30",
    "pubmed_id": "27469359",
    "results": "Radiation dosimetry was acceptable, with effective doses of 9.5 \u03bcSv/MBq (intravenous administration) and 18.1 \u03bcSv/MBq (oral administration). Whole-body PET revealed that ",
    "title": "In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses.",
    "xml": "<Element 'PubmedArticle' at 0x788505754a90>"
}