{
    "abstract": "Forty-eight women with menstrual dysfunction and clinical evidence of excess androgen production were subjected to an adrenocorticotropic hormone stimulation test that demonstrated the presence of a late-onset 11- or 21-adrenocortical hydroxylase deficiency. Adrenocortical suppression therapy with prednisone was then instituted. Eighty-three percent of the women improved and either conceived, established normal regular menstrual cycles, or noted a significant increase in menstrual regularity. In patients desiring fertility, there was an overall pregnancy rate of 64% and a corrected pregnancy rate of 93%. Some of these patients were given clomiphene in addition to the prednisone. The present study has demonstrated that an adrenocortical abnormality, characterized by a partial deficiency of either 11-hydroxylase or 21-hydroxylase, plays a significant role in many women with clinical evidence of hyperandrogenism and menstrual abnormalities. In such women, adrenocortical suppression is indicated and often results in a significant improvement of the menstrual disturbance.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "M D",
            "initials": "MD",
            "lastname": "Birnbaum"
        },
        {
            "affiliation": null,
            "firstname": "L I",
            "initials": "LI",
            "lastname": "Rose"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": null,
    "journal": "Obstetrics and gynecology",
    "keywords": [],
    "methods": null,
    "publication_date": "1984-04-01",
    "pubmed_id": "6322077",
    "results": null,
    "title": "Late onset adrenocortical hydroxylase deficiencies associated with menstrual dysfunction.",
    "xml": "<Element 'PubmedArticle' at 0x788504b29580>"
}