{
    "abstract": "Half of people post pulmonary embolism (PE) experience ongoing symptoms such as dyspnoea, anxiety and depression, exercise limitation and fatigue. These symptoms can reduce their quality of life (QoL), psychological wellbeing, and functional capacity. The efficacy of rehabilitation interventions to prevent and manage these symptoms has not been established. The objectives of this review were to synthesise the evidence on interventions targeting QoL, psychological wellbeing, and functional capacity post PE, and to identify intervention characteristics and behaviour change techniques (BCTs) that contribute to successful rehabilitation programmes.\nThe PRISMA reporting guidelines were followed. Five electronic databases were searched; PubMED, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and PsycINFO. Searching began in November 2023, with the final search run in December 2023. Studies using experimental designs, in adult populations, employing rehabilitation programmes to target patient outcomes post PE were included. The Template of Intervention Description and Replication (TIDieR) 12 item checklist was used to score the description and replicability of the intervention and control conditions and the BCT taxonomy V1 was used to identify BCTs across the included interventions. Data was extracted and a best evidence synthesis was conducted.\nOf 7321 studies identified, 12 studies (n\u00a0=\u00a0648 participants) met the inclusion criteria; four randomised controlled trials (RCTs), one pilot RCT study and seven prospective cohort studies, all conducted at different timepoints in the disease course, using different selection criteria and with different interventions. Eight of the 12 included studies were evaluated as being of low quality based on the Effective Public Health Practice Project (EPHPP) tool. The mean TIDieR score was six out of 24 for intervention completeness and reporting. Twenty five BCTs were identified across the included studies, three of which were identified in all studies (\"Instruction on how to perform the behaviour\", \"demonstration of the behaviour\" and \"behaviour practice/ rehearsal\"). Overall the best evidence synthesis provided a mixed level of evidence for the effectiveness of rehabilitation interventions post PE. There is a limited level of evidence that rehabilitation has a positive effect on patient perceived QoL and inconsistent evidence that rehabilitation has any effect on psychological wellbeing. There is however, a moderate level of evidence to support the effectiveness of rehabilitation when it comes to improving functional capacity.\nThis review highlights heterogeneity across available studies and provides some evidence supporting rehabilitation programmes to improve functional capacity in people living post PE. However, further research is required to establish their effectiveness for improving QoL and psychological wellbeing. Although a number of BCTs were identified, few of those identified were linked to behaviour change theory. This, combined with limited reporting of components of the rehabilitation interventions, restricted evaluation of their effectiveness.\nPROSPERO 2020 CRD42023459411 Available from: https://www.crd.york.ac.uk/prospero/#recordDetails.",
    "authors": [
        {
            "affiliation": "School of Public Health, Physiotherapy & Sports Science, Health Sciences Building, University College Dublin, D04 V1W8, Ireland. Electronic address: caoimhe.kenny2@ucdconnect.ie.",
            "firstname": "Caoimhe",
            "initials": "C",
            "lastname": "Kenny"
        },
        {
            "affiliation": "School of Public Health, Physiotherapy & Sports Science, Health Sciences Building, University College Dublin, D04 V1W8, Ireland. Electronic address: olive.lennon@ucd.ie.",
            "firstname": "Olive",
            "initials": "O",
            "lastname": "Lennon"
        },
        {
            "affiliation": "LUMC Main Building, Albinusdreef 2, 2333 ZA Leiden, Netherlands. Electronic address: f.a.klok@lumc.nl.",
            "firstname": "Frederikus A",
            "initials": "FA",
            "lastname": "Klok"
        },
        {
            "affiliation": "School of Public Health, Physiotherapy & Sports Science, Health Sciences Building, University College Dublin, D04 V1W8, Ireland. Electronic address: james.matthews@ucd.ie.",
            "firstname": "James",
            "initials": "J",
            "lastname": "Matthews"
        },
        {
            "affiliation": "Mater Misericordiae University Hospital, Dublin 7, Ireland. Electronic address: fniainle@mater.ie.",
            "firstname": "Fionnuala Ni",
            "initials": "FN",
            "lastname": "Ainle"
        },
        {
            "affiliation": "Yawkey Center Outpatient Care, 32 Fruit Street, Boston, MA 02114, United States of America. Electronic address: rprosovsky@mgh.harvard.edu.",
            "firstname": "Rachel",
            "initials": "R",
            "lastname": "Rosovsky"
        },
        {
            "affiliation": "School of Public Health, Physiotherapy & Sports Science, Health Sciences Building, University College Dublin, D04 V1W8, Ireland. Electronic address: grainne.odonoghue@ucd.ie.",
            "firstname": "Grainne O",
            "initials": "GO",
            "lastname": "Donoghue"
        }
    ],
    "conclusions": "This review highlights heterogeneity across available studies and provides some evidence supporting rehabilitation programmes to improve functional capacity in people living post PE. However, further research is required to establish their effectiveness for improving QoL and psychological wellbeing. Although a number of BCTs were identified, few of those identified were linked to behaviour change theory. This, combined with limited reporting of components of the rehabilitation interventions, restricted evaluation of their effectiveness.",
    "copyrights": "Copyright \u00a9 2024 Elsevier Ltd. All rights reserved.",
    "doi": "10.1016/j.thromres.2024.109242",
    "journal": "Thrombosis research",
    "keywords": [
        "Exercise",
        "Functional capacity",
        "Post-pulmonary embolism syndrome",
        "Psychological wellbeing",
        "Pulmonary embolisms(s)",
        "Quality of life",
        "Rehabilitation",
        "Training"
    ],
    "methods": null,
    "publication_date": "2024-12-29",
    "pubmed_id": "39731975",
    "results": "Of 7321 studies identified, 12 studies (n\u00a0=\u00a0648 participants) met the inclusion criteria; four randomised controlled trials (RCTs), one pilot RCT study and seven prospective cohort studies, all conducted at different timepoints in the disease course, using different selection criteria and with different interventions. Eight of the 12 included studies were evaluated as being of low quality based on the Effective Public Health Practice Project (EPHPP) tool. The mean TIDieR score was six out of 24 for intervention completeness and reporting. Twenty five BCTs were identified across the included studies, three of which were identified in all studies (\"Instruction on how to perform the behaviour\", \"demonstration of the behaviour\" and \"behaviour practice/ rehearsal\"). Overall the best evidence synthesis provided a mixed level of evidence for the effectiveness of rehabilitation interventions post PE. There is a limited level of evidence that rehabilitation has a positive effect on patient perceived QoL and inconsistent evidence that rehabilitation has any effect on psychological wellbeing. There is however, a moderate level of evidence to support the effectiveness of rehabilitation when it comes to improving functional capacity.",
    "title": "Effectiveness of rehabilitation programmes targeting quality of life, psychological wellbeing, and functional capacity in pulmonary embolism survivors; a systematic review and best evidence synthesis.",
    "xml": "<Element 'PubmedArticle' at 0x788503a7cea0>"
}