{
    "abstract": "The management of posterior deep endometriosis is not consensual. This is due to a great heterogeneity of data from the literature. Many series were small and overall, predictors of pregnancy were not all included and analyzed by multivariate analysis. We conducted this study to evaluate the factors associated with pregnancy during the first two in vitro fertilization (IVF) attempts in infertile women with posterior deep endometriosis.\n230 women were included in this retrospective observational study, between January 1st, 2007 and September 30th, 2013, at the University Hospital of Lille. A large set of variables were recorded and their association with the chance of pregnancy was analyzed by multivariate analysis (MVA), including patients' features, endometriosis items, surgery procedures and IVF data.\nAfter 2 IVF attempts, 48.7% of the 230 women achieved a pregnancy, including 39.1% of ongoing pregnancies. Logistic regression analysis retained five variables significantly associated to the chance of pregnancy: oocyte retrieval number (OR=0.468 (0.296-0.739) p=0.001), age (OR=0.888 (0.811-0.974) p=0.011), single embryo transfer number (OR=1.494 (1.036-2.153) p=0.031), presence of a recto-uterine nodule (OR=0.454 (0.235-0.877) p=0.019) and IVF technique (OR=0.509 (0.272-0.951) p=0.034).\nThe presence of a recto uterine nodule is associated with a lower chance of pregnancy after IVF. It has to be checked by prospective studies whether the finding of a recto-uterine nodule whose pejorative effect has not been reported so far should encourage to perform surgery before IVF in patients with deep endometriosis.",
    "authors": [
        {
            "affiliation": "Service de chirurgie gyn\u00e9cologique, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59 037 Lille, France; Facult\u00e9 de M\u00e9decine H. Warembourg, Universit\u00e9 de Lille, France. Electronic address: chrystele.rubod@chru-lille.fr.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Rubod"
        },
        {
            "affiliation": "Service de chirurgie gyn\u00e9cologique, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59 037 Lille, France; Service de M\u00e9decine de la Reproduction, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59037 Lille, France.",
            "firstname": "A",
            "initials": "A",
            "lastname": "Fouquet"
        },
        {
            "affiliation": "Service de chirurgie gyn\u00e9cologique, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59 037 Lille, France.",
            "firstname": "S",
            "initials": "S",
            "lastname": "Bartolo"
        },
        {
            "affiliation": "Service de chirurgie gyn\u00e9cologique, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59 037 Lille, France; Service de M\u00e9decine de la Reproduction, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59037 Lille, France.",
            "firstname": "J",
            "initials": "J",
            "lastname": "Lepage"
        },
        {
            "affiliation": "Service de M\u00e9decine de la Reproduction, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59037 Lille, France.",
            "firstname": "A",
            "initials": "A",
            "lastname": "Capelle"
        },
        {
            "affiliation": "Service de M\u00e9decine de la Reproduction, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59037 Lille, France.",
            "firstname": "C",
            "initials": "C",
            "lastname": "Lefebvre"
        },
        {
            "affiliation": "Service de radiologie, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59037 Lille, France.",
            "firstname": "E",
            "initials": "E",
            "lastname": "Kamus"
        },
        {
            "affiliation": "Service de M\u00e9decine de la Reproduction, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59037 Lille, France; Facult\u00e9 de M\u00e9decine H. Warembourg, Universit\u00e9 de Lille, France.",
            "firstname": "D",
            "initials": "D",
            "lastname": "Dewailly"
        },
        {
            "affiliation": "Service de chirurgie gyn\u00e9cologique, H\u00f4pital Jeanne de Flandre, CHRU de Lille, 59 037 Lille, France; Facult\u00e9 de M\u00e9decine H. Warembourg, Universit\u00e9 de Lille, France.",
            "firstname": "P",
            "initials": "P",
            "lastname": "Collinet"
        }
    ],
    "conclusions": "The presence of a recto uterine nodule is associated with a lower chance of pregnancy after IVF. It has to be checked by prospective studies whether the finding of a recto-uterine nodule whose pejorative effect has not been reported so far should encourage to perform surgery before IVF in patients with deep endometriosis.",
    "copyrights": "Copyright \u00a9 2018 Elsevier Masson SAS. All rights reserved.",
    "doi": "10.1016/j.jogoh.2018.06.002",
    "journal": "Journal of gynecology obstetrics and human reproduction",
    "keywords": [
        "ART",
        "Deep pelvic endometriosis",
        "IVF",
        "Recto-uterine endometriosis nodule",
        "Surgery"
    ],
    "methods": null,
    "publication_date": "2018-06-18",
    "pubmed_id": "29908951",
    "results": "After 2 IVF attempts, 48.7% of the 230 women achieved a pregnancy, including 39.1% of ongoing pregnancies. Logistic regression analysis retained five variables significantly associated to the chance of pregnancy: oocyte retrieval number (OR=0.468 (0.296-0.739) p=0.001), age (OR=0.888 (0.811-0.974) p=0.011), single embryo transfer number (OR=1.494 (1.036-2.153) p=0.031), presence of a recto-uterine nodule (OR=0.454 (0.235-0.877) p=0.019) and IVF technique (OR=0.509 (0.272-0.951) p=0.034).",
    "title": "Factors associated with pregnancy after in vitro fertilization in infertile patients with posterior deep pelvic endometriosis: A retrospective study.",
    "xml": "<Element 'PubmedArticle' at 0x788506f053a0>"
}