{
    "abstract": "SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of \u03b2-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including ",
    "authors": [
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA steve.wring@scynexis.com.",
            "firstname": "Stephen A",
            "initials": "SA",
            "lastname": "Wring"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "Ryan",
            "initials": "R",
            "lastname": "Randolph"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "SeongHee",
            "initials": "S",
            "lastname": "Park"
        },
        {
            "affiliation": "Merck & Co., Inc., Rahway, New Jersey, USA.",
            "firstname": "George",
            "initials": "G",
            "lastname": "Abruzzo"
        },
        {
            "affiliation": "Merck & Co., Inc., Rahway, New Jersey, USA.",
            "firstname": "Qing",
            "initials": "Q",
            "lastname": "Chen"
        },
        {
            "affiliation": "Merck & Co., Inc., Rahway, New Jersey, USA.",
            "firstname": "Amy",
            "initials": "A",
            "lastname": "Flattery"
        },
        {
            "affiliation": "Merck & Co., Inc., Rahway, New Jersey, USA.",
            "firstname": "Graig",
            "initials": "G",
            "lastname": "Garrett"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Peel"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "Russell",
            "initials": "R",
            "lastname": "Outcalt"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "Kendall",
            "initials": "K",
            "lastname": "Powell"
        },
        {
            "affiliation": "Merck & Co., Inc., Rahway, New Jersey, USA.",
            "firstname": "Michelle",
            "initials": "M",
            "lastname": "Trucksis"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "David",
            "initials": "D",
            "lastname": "Angulo"
        },
        {
            "affiliation": "SCYNEXIS, Inc., Jersey City, New Jersey, USA.",
            "firstname": "Katyna",
            "initials": "K",
            "lastname": "Borroto-Esoda"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2017 Wring et al.",
    "doi": "10.1128/AAC.02068-16\n10.1093/cid/civ1194\n10.1093/jac/dks466\n10.1128/AAC.01588-12\n10.1128/AAC.02145-13\n10.1128/AAC.04445-14\n10.1128/AAC.44.9.2310-2318.2000\n10.1016/S0169-409X(00)00128-9\n10.1016/0006-2952(94)90520-7\n10.1016/S0723-2020(00)80062-4\n10.1016/j.bmcl.2012.05.031\n10.1023/A:1018943613122\n10.1128/AAC.01596-07\n10.1128/CMR.00046-13\n10.1128/AAC.49.12.5058-5068.2005\n10.1128/AAC.00507-06\n10.1111/j.1469-0691.2009.02913.x\n10.1128/AAC.48.3.815-823.2004\n10.1248/bpb.27.1154\n10.1128/AAC.48.4.1272-1280.2004\n10.1093/jac/dkl015\n10.1128/AAC.45.10.2845-2855.2001\n10.1128/AAC.45.2.596-600.2001\n10.1128/AAC.45.12.3322-3327.2001\n10.2147/tcrm.2007.3.1.71\n10.1016/S0140-6736(03)14472-8\n10.1128/AAC.01584-09\n10.1016/j.idc.2006.06.007\n10.1128/AAC.00105-07\n10.1128/AAC.46.12.3846-3853.2002\n10.1128/AAC.01536-06",
    "journal": "Antimicrobial agents and chemotherapy",
    "keywords": [
        "SCY-078",
        "candidemia",
        "fungal disease",
        "pharmacokinetics"
    ],
    "methods": null,
    "publication_date": "2017-02-01",
    "pubmed_id": "28137806\n26679628\n23190764\n23229479\n24323472\n25512406\n10952573\n11259831\n8185657\n11108011\n22672801\n10534321\n8378254\n18443124\n24396137\n16304173\n16954319\n19673971\n9371330\n14982770\n15256761\n15047529\n16464895\n11557479\n11158761\n11709303\n18360617\n14550704\n20385855\n16984875\n17307976\n12435687\n17420211",
    "results": null,
    "title": "Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.",
    "xml": "<Element 'PubmedArticle' at 0x788503d413a0>"
}