{
    "abstract": "Since the dawn of the new millennium, Candida species have been increasingly implicated as a cause of both healthcare-associated as well as opportunistic yeast infections, due to the widespread use of indwelling medical devices, total parenteral nutrition, systemic corticosteroids, cytotoxic chemotherapy, and broad-spectrum antibiotics. Candida tropicalis is a pathogenic Candida species associated with considerable morbidity, mortality, and drug resistance issues on a global scale.\nWe report a case of a 43-year-old man who was admitted to our hospital for further management of severe coronavirus disease 2019 (COVID-19) pneumonia. During his stay in the ward, he received systemic corticosteroids for a total duration of 32 days. A broad-spectrum antibiotic (piperacillin-tazobactam) was also given due to copious amounts of tracheostomy secretions.\nThe patient's fever recurred following an afebrile interval of 11 days, and C. tropicalis was cultured from his blood. The yeast was highly resistant to fluconazole and voriconazole but remained susceptible to echinocandins. Unfortunately, the patient was unable to receive any echinocandin and eventually succumbed to candidemia.\nMultilocus sequence typing was used to characterize C. tropicalis as a novel diploid sequence type (i.e., 1515) that has not been previously reported.",
    "authors": [
        {
            "affiliation": "Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.",
            "firstname": "Chuan H",
            "initials": "CH",
            "lastname": "Ding"
        },
        {
            "affiliation": "Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.",
            "firstname": "Shiamala D",
            "initials": "SD",
            "lastname": "Navarathinam"
        },
        {
            "affiliation": "UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.",
            "firstname": "Hui-Min",
            "initials": "HM",
            "lastname": "Neoh"
        },
        {
            "affiliation": "Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.",
            "firstname": "Toh L",
            "initials": "TL",
            "lastname": "Tan"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright (c) 2024 Chuan H Ding, Shiamala D Navarathinam, Hui-Min Neoh, Toh L Tan.",
    "doi": "10.3855/jidc.20096",
    "journal": "Journal of infection in developing countries",
    "keywords": [
        "COVID-19",
        "Candida tropicalis",
        "candidemia",
        "multilocus sequence typing"
    ],
    "methods": null,
    "publication_date": "2025-01-26",
    "pubmed_id": "39863954",
    "results": "The patient's fever recurred following an afebrile interval of 11 days, and C. tropicalis was cultured from his blood. The yeast was highly resistant to fluconazole and voriconazole but remained susceptible to echinocandins. Unfortunately, the patient was unable to receive any echinocandin and eventually succumbed to candidemia.",
    "title": "The first reported case of candidemia caused by the novel Candida tropicalis diploid sequence type 1515.",
    "xml": "<Element 'PubmedArticle' at 0x788501f8c720>"
}