{
    "abstract": "The profession of a locomotive engineer involves stress, lack of adequate sleep and rest, and a sedentary lifestyle, all of which can contribute to the development of erectile dysfunction (ErD) as well as arterial hypertension.\nConsecutive patients of the railway hospital in Barnaul with arterial hypertension aged 30-60 who work as machinists or assistant locomotive drivers were enrolled. Those who have symptoms of ErD were randomized into three groups: group 1 received an endogenous nitric oxide-synthase (NOS) activator, group 2 received a combination of endogenous NOS activator and phosphodiesterase type 5 inhibitor (PDE-5i), and group 3 received no additional treatment for ErD. 20 individuals belonged to the control group without ErD. A follow-up was conducted after 2 and 4\u2009months.\nA total of 85 individuals were examined (65 with symptoms of ErD). After 2\u2009months of treatment, no significant changes in biomarkers and LDF (laser Doppler flowmetry) values were observed in groups 1 and 3. In group 2, ET-1 (endothelin-1) and hs-CRP (high-sensitivity C-reactive protein) returned to reference levels, and ischemic manifestations decreased. After 4\u2009months, group 1 had increased mean blood flow and hs-CRP returned to reference levels. Group 2 showed improved microhemodynamics and biomarkers values. Group 2 patients had a higher IIEF and ICF total scores.\nThe combination of hypotensive drugs, PDE-5i, and NOS activator was the most effective method of treatment, improving hemodynamics and reparative properties of the endothelium by removing the substrate for thrombus formation. Treatment with an NO-synthase activator was shown to partially eliminate pathological processes in the endothelium.",
    "authors": [
        {
            "affiliation": "Altai Regional Clinical Perinatal Center \"DAR\", Ministry of Health of Russia, Barnaul, Russian Federation.",
            "firstname": "Arkhipova",
            "initials": "A",
            "lastname": "Anzhelika"
        },
        {
            "affiliation": "Urology Department of Clinical Hospital \"Russian Railways-Medicine\" of Barnaul, Barnaul, Russian Federation.",
            "firstname": "Neymark",
            "initials": "N",
            "lastname": "Boris"
        },
        {
            "affiliation": "Department of Urology and Andrology With the Course of Advanced Training, Altai State Medical University of the Ministry of Health of Russia, Barnaul, Russian Federation.",
            "firstname": "Neymark",
            "initials": "N",
            "lastname": "Alexandr"
        },
        {
            "affiliation": "Institute of the Clinical Medicine Named after N.V. Sklifosovsky, Sechenov University, Moscow, Russia.",
            "firstname": "Tyshkevich",
            "initials": "T",
            "lastname": "Georgy"
        },
        {
            "affiliation": "Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.",
            "firstname": "Morozov",
            "initials": "M",
            "lastname": "Andrey"
        },
        {
            "affiliation": "Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.",
            "firstname": "Korolev",
            "initials": "K",
            "lastname": "Dmitry"
        },
        {
            "affiliation": "Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.",
            "firstname": "Rapoport",
            "initials": "R",
            "lastname": "Leonid"
        },
        {
            "affiliation": "Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.",
            "firstname": "Spivak",
            "initials": "S",
            "lastname": "Leonid"
        },
        {
            "affiliation": "National Medical Research Center of Hematology, Ministry of Health of Russia; Hemostasis Laboratory of the Clinical Research Center of the Scientific Cluster of the Altai State Medical University, Ministry of Health of Russia, Barnaul, Russian Federation.",
            "firstname": "Momot",
            "initials": "M",
            "lastname": "Andrey"
        }
    ],
    "conclusions": "The combination of hypotensive drugs, PDE-5i, and NOS activator was the most effective method of treatment, improving hemodynamics and reparative properties of the endothelium by removing the substrate for thrombus formation. Treatment with an NO-synthase activator was shown to partially eliminate pathological processes in the endothelium.",
    "copyrights": null,
    "doi": "10.1177/03915603251334076",
    "journal": "Urologia",
    "keywords": [
        "Erectile dysfunction",
        "endogenous NO-synthase activator",
        "phosphodiesterase type 5 inhibitor (PDE-5i)",
        "railway station workers",
        "workplace hypertension"
    ],
    "methods": null,
    "publication_date": "2025-04-26",
    "pubmed_id": "40285655",
    "results": "A total of 85 individuals were examined (65 with symptoms of ErD). After 2\u2009months of treatment, no significant changes in biomarkers and LDF (laser Doppler flowmetry) values were observed in groups 1 and 3. In group 2, ET-1 (endothelin-1) and hs-CRP (high-sensitivity C-reactive protein) returned to reference levels, and ischemic manifestations decreased. After 4\u2009months, group 1 had increased mean blood flow and hs-CRP returned to reference levels. Group 2 showed improved microhemodynamics and biomarkers values. Group 2 patients had a higher IIEF and ICF total scores.",
    "title": "Erectile dysfunction in railway station workers: A randomized study of different treatment approaches.",
    "xml": "<Element 'PubmedArticle' at 0x788503ab4900>"
}