{
    "abstract": "This study unveils the unique origins, evolution, and genetic variations of the Yangba cattle, an endangered breed in China, through a comparative genomic analysis involving 202 individuals from 21 domestic and international breeds. Genetic component analysis revealed that the Yangba cattle comprise four ancestral lineages: Eurasian taurine (18%), East Asian taurine (26%), Chinese indicine (39%), and Indian indicine (17%). Their high genetic diversity and low inbreeding coefficient set them apart significantly from mainstream commercial breeds. Gene introgression analysis indicated that the influx of genetic material from East Asian taurine has enhanced the Yangba cattle's adaptability to environmental stress, while the introgression from Chinese indicine has endowed them with unique advantages in muscle development and tissue repair. A genome-wide selection scan identified strong positive selection signals for genes such as ",
    "authors": [
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Bao",
            "initials": "B",
            "lastname": "Cai"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Yandong",
            "initials": "Y",
            "lastname": "Kang"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Ziqiang",
            "initials": "Z",
            "lastname": "Ding"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Shaoke",
            "initials": "S",
            "lastname": "Guo"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Mengli",
            "initials": "M",
            "lastname": "Cao"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Liyan",
            "initials": "L",
            "lastname": "Hu"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Ben",
            "initials": "B",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.",
            "firstname": "Xingdong",
            "initials": "X",
            "lastname": "Wang"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.\nKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China.",
            "firstname": "Jie",
            "initials": "J",
            "lastname": "Pei"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.\nKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China.",
            "firstname": "Qianyun",
            "initials": "Q",
            "lastname": "Ge"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.\nKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China.",
            "firstname": "Lin",
            "initials": "L",
            "lastname": "Xiong"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.\nKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China.",
            "firstname": "Xiaoyun",
            "initials": "X",
            "lastname": "Wu"
        },
        {
            "affiliation": "Key Laboratory of Yak Breeding of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.\nKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China.",
            "firstname": "Xian",
            "initials": "X",
            "lastname": "Guo"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ani15071065\n10.1038/s41437-021-00428-7\n10.1038/s41598-017-16438-7\n10.3389/fgene.2020.533052\n10.1093/jas/skad006\n10.1186/s12864-019-5822-y\n10.1111/age.13416\n10.1080/10495398.2023.2298406\n10.1038/s41598-021-96896-2\n10.3168/jds.2022-22665\n10.1186/s12864-024-09959-9\n10.1111/age.13155\n10.1186/s12864-020-07340-0\n10.1186/s12864-024-10482-0\n10.3390/genes15091113\n10.1186/s12864-020-07035-6\n10.1093/bioinformatics/bty560\n10.1093/bioinformatics/btp352\n10.1093/bioinformatics/btv098\n10.1093/bioinformatics/btp324\n10.1101/gr.107524.110\n10.1093/bioinformatics/btw044\n10.1093/nar/gkq603\n10.1093/bioinformatics/btr330\n10.1093/bioinformatics/bty875\n10.1086/519795\n10.1186/1471-2105-12-246\n10.1093/molbev/msab120\n10.1093/nar/gkab301\n10.1111/1755-0998.13265\n10.1093/bioinformatics/btz030\n10.1093/molbev/msu211\n10.1093/nar/gkab447\n10.1038/s41467-018-04737-0\n10.1080/10495398.2021.1998094\n10.1007/s44154-023-00101-5\n10.1016/j.gene.2021.145949\n10.3389/fgene.2021.653927\n10.1002/ctm2.1754\n10.3390/genes15040433\n10.3389/fgene.2022.898522\n10.3892/mmr.2020.11133\n10.1038/srep16523\n10.1371/journal.pone.0148112\n10.1016/j.bj.2023.100628\n10.1038/s41598-021-00682-z\n10.3390/ani11071927\n10.3390/biology14010040\n10.3390/genes13101848\n10.1007/s12020-021-02819-6\n10.1158/0008-5472.CAN-20-3450\n10.1016/j.yexcr.2020.112178\n10.5713/ab.23.0365\n10.1038/s41598-022-14376-7",
    "journal": "Animals : an open access journal from MDPI",
    "keywords": [
        "endangered Yangba cattle",
        "gene introgression",
        "phylogeny",
        "population genetics",
        "whole-genome resequencing"
    ],
    "methods": null,
    "publication_date": "2025-04-12",
    "pubmed_id": "40218458\n33782560\n29170422\n33391332\n36617259\n31200634\n38436096\n38193808\n34462508\n37028956\n38254050\n34783059\n33421990\n38834950\n39336704\n32917133\n30423086\n19505943\n25697820\n19451168\n20644199\n26826718\n20601685\n21653522\n30321304\n17701901\n21682921\n33892491\n33885785\n33012121\n30668635\n25015648\n34086934\n29904051\n34762022\n37676416\n34481004\n34306007\n39095325\n38674368\n36263427\n32626929\n26563778\n26821164\n37487907\n34725398\n34203505\n39857271\n36292733\n34251576\n33766890\n32679235\n38575125\n35688969",
    "results": null,
    "title": "Genomic Characterization of Crossbred-Driven Adaptation in the Endangered Yangba Cattle of China.",
    "xml": "<Element 'PubmedArticle' at 0x7885039f9c60>"
}