{
    "abstract": "Organometallic complexes offer a wide range of properties like structural variety, reaction kinetics, tunable lipophilicity and alternate mechanisms of activation under physiological conditions compared to platinum chemotherapeutics and are thus being explored for their potential anticancer applications. In this regard, gold(i) organometallics hold a pivotal position for their ability to act on biological targets different from DNA (which is the primary target of platinum therapeutics), such as thioredoxin reductase. Here, we report on the stability, ",
    "authors": [
        {
            "affiliation": "Institute of Medicinal and Pharmaceutical Chemistry, Technische Universit\u00e4t Braunschweig Beethovenstr. 55 38106 Braunschweig Germany ingo.ott@tu-braunschweig.de.\nDepartment of Chemistry, BITS Pilani K K Birla Goa Campus NH 17B Bypass Road Goa 403726 India uttarab@goa.bits-pilani.ac.in.",
            "firstname": "Uttara",
            "initials": "U",
            "lastname": "Basu"
        },
        {
            "affiliation": "Institute of Medicinal and Pharmaceutical Chemistry, Technische Universit\u00e4t Braunschweig Beethovenstr. 55 38106 Braunschweig Germany ingo.ott@tu-braunschweig.de.",
            "firstname": "Anna",
            "initials": "A",
            "lastname": "Wilsmann"
        },
        {
            "affiliation": "Institute of Medicinal and Pharmaceutical Chemistry, Technische Universit\u00e4t Braunschweig Beethovenstr. 55 38106 Braunschweig Germany ingo.ott@tu-braunschweig.de.",
            "firstname": "Sebastian",
            "initials": "S",
            "lastname": "T\u00fcrck"
        },
        {
            "affiliation": "Institute of Medicinal and Pharmaceutical Chemistry, Technische Universit\u00e4t Braunschweig Beethovenstr. 55 38106 Braunschweig Germany ingo.ott@tu-braunschweig.de.",
            "firstname": "Henrik",
            "initials": "H",
            "lastname": "Hoffmeister"
        },
        {
            "affiliation": "Institute of Medicinal and Pharmaceutical Chemistry, Technische Universit\u00e4t Braunschweig Beethovenstr. 55 38106 Braunschweig Germany ingo.ott@tu-braunschweig.de.",
            "firstname": "Matthias",
            "initials": "M",
            "lastname": "Schiedel"
        },
        {
            "affiliation": "Chimie Paris Tech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences 75005 Paris France.",
            "firstname": "Gilles",
            "initials": "G",
            "lastname": "Gasser"
        },
        {
            "affiliation": "Institute of Medicinal and Pharmaceutical Chemistry, Technische Universit\u00e4t Braunschweig Beethovenstr. 55 38106 Braunschweig Germany ingo.ott@tu-braunschweig.de.",
            "firstname": "Ingo",
            "initials": "I",
            "lastname": "Ott"
        }
    ],
    "conclusions": null,
    "copyrights": "This journal is \u00a9 The Royal Society of Chemistry.",
    "doi": "10.1039/d4md00964a",
    "journal": "RSC medicinal chemistry",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-04-09",
    "pubmed_id": "40201730\n38116755\n36847211\n37071737\n32900936\n11749494\n37958311\n32864503\n34895650\n21077686\n34850406\n38435529\n37937471\n36219576\n37291753\n34719915\n38646683\n31683128\n30516775\n28594007\n33151608\n26850306\n19123857\n24302256\n30187047\n26528965\n24677779\n26732365\n14757168\n37760418\n22848030\n32529715\n24123460\n29057040\n32140957\n37410388\n32319768\n35602949\n24763048\n9919525\n20954152\n27346647\n8674165\n17406593\n17512005",
    "results": null,
    "title": "Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold(i) alkynyl complex.",
    "xml": "<Element 'PubmedArticle' at 0x78850516f060>"
}