{
    "abstract": "Patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), particularly of the base of tongue, have a high rate of occult nodal disease in the contralateral neck. The risk of failure in the contralateral neck is reduced with elective treatment. The optimal treatment strategy to minimize treatment-related toxicity while preserving regional control in the contralateral neck has not been elucidated.\nCross-sectional study of patients who underwent elective contralateral neck dissection as part of primary surgical treatment for HPV-related OPSCC between January 2002 and December 2018.\nTertiary care center.\nPatients who underwent elective contralateral neck dissection as part of primary surgical treatment for HPV-related OPSCC between January 2002 and December 2018 were selected for inclusion. Long-term patient-reported functional outcomes were assessed via telephone at the time of data collection.\nIn total, 64 patients met the criteria for inclusion with a median follow-up of 58.5 months. In total, 56 patients (88%) had a primary cancer within the base of tongue or glossotonsillar sulcus. In total, 12 patients (19%) were found to have occult nodal metastasis in the contralateral neck, of whom 9 received adjuvant contralateral neck radiation. None of the patients who had node-negative contralateral neck dissections went on to receive radiation in the contralateral neck. Two patients (3%) recurred locally, two patients (3%) developed ipsilateral regional recurrence, and four patients (6%) developed distant metastasis. There were no regional recurrences within the contralateral neck. Five-year progression-free survival was 82.0%, whereas 5-year locoregional control was 93.0%. The mean Neck-Dissection Impairment Index was 94.4 with a median interval time of 92 months after surgery.\nElective contralateral neck dissection in patients with HPV-related OPSCC provides excellent regional control with minimal long-term functional impairment, and most patients can be spared contralateral neck radiation without compromising oncologic outcomes. This may decrease long-term toxicity related to bilateral neck irradiation.",
    "authors": [
        {
            "affiliation": "Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.",
            "firstname": "Ray Y",
            "initials": "RY",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.",
            "firstname": "Molly E Heft",
            "initials": "MEH",
            "lastname": "Neal"
        },
        {
            "affiliation": "Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nHead and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Wade L",
            "initials": "WL",
            "lastname": "Thorstad"
        },
        {
            "affiliation": "Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nHead and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Hiram A",
            "initials": "HA",
            "lastname": "Gay"
        },
        {
            "affiliation": "Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nHead and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Anthony J",
            "initials": "AJ",
            "lastname": "Apicelli"
        },
        {
            "affiliation": "Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nHead and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Michael J",
            "initials": "MJ",
            "lastname": "Moravan"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDivision of Medical Oncology and Alvin J. Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Douglas R",
            "initials": "DR",
            "lastname": "Adkins"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDivision of Medical Oncology and Alvin J. Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Peter J",
            "initials": "PJ",
            "lastname": "Oppelt"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Patrik",
            "initials": "P",
            "lastname": "Pipkorn"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Jason T",
            "initials": "JT",
            "lastname": "Rich"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Paul",
            "initials": "P",
            "lastname": "Zolkind"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Randal C",
            "initials": "RC",
            "lastname": "Paniello"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Sidharth V",
            "initials": "SV",
            "lastname": "Puram"
        },
        {
            "affiliation": "Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.\nDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.",
            "firstname": "Ryan S",
            "initials": "RS",
            "lastname": "Jackson"
        }
    ],
    "conclusions": "Elective contralateral neck dissection in patients with HPV-related OPSCC provides excellent regional control with minimal long-term functional impairment, and most patients can be spared contralateral neck radiation without compromising oncologic outcomes. This may decrease long-term toxicity related to bilateral neck irradiation.",
    "copyrights": "\u00a9 2025 American Academy of Otolaryngology\u2013Head and Neck Surgery Foundation.",
    "doi": "10.1002/ohn.1227",
    "journal": "Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery",
    "keywords": [
        "elective neck dissection",
        "head and neck cancer",
        "oropharyngeal cancer",
        "patient\u2010reported outcomes",
        "radiation"
    ],
    "methods": null,
    "publication_date": "2025-03-19",
    "pubmed_id": "40105620",
    "results": "In total, 64 patients met the criteria for inclusion with a median follow-up of 58.5 months. In total, 56 patients (88%) had a primary cancer within the base of tongue or glossotonsillar sulcus. In total, 12 patients (19%) were found to have occult nodal metastasis in the contralateral neck, of whom 9 received adjuvant contralateral neck radiation. None of the patients who had node-negative contralateral neck dissections went on to receive radiation in the contralateral neck. Two patients (3%) recurred locally, two patients (3%) developed ipsilateral regional recurrence, and four patients (6%) developed distant metastasis. There were no regional recurrences within the contralateral neck. Five-year progression-free survival was 82.0%, whereas 5-year locoregional control was 93.0%. The mean Neck-Dissection Impairment Index was 94.4 with a median interval time of 92 months after surgery.",
    "title": "Long-Term Outcomes After Elective Contralateral Neck Dissection for HPV-Related Oropharyngeal Cancer.",
    "xml": "<Element 'PubmedArticle' at 0x788501f35ad0>"
}