{
    "abstract": "An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Forty percent of the neoplastic cells were Ki-67 positive. Cytogenetic studies indicated a trisomy 8 (associated with worse prognosis) and a t(12; 17) translocation. Desmin, smooth muscle actin, pancytokeratin, CAM 5.2, adipophilin, tryptase, S100, SOX10, MART1, and E-cadherin were negative, ruling out a nonhematopoietic tumor. The conjunctival lesion was diagnosed as a myeloid sarcoma with megakaryoblastic differentiation, a rare variant. It probably arose from a myelodysplastic syndrome. This is the first case of its type to develop in the conjunctiva.",
    "authors": [
        {
            "affiliation": "David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.",
            "firstname": "Frederick A",
            "initials": "FA",
            "lastname": "Jakobiec"
        },
        {
            "affiliation": "David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.",
            "firstname": "Natalie",
            "initials": "N",
            "lastname": "Wolkow"
        },
        {
            "affiliation": "Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, Rhode Island, USA.",
            "firstname": "Fouad R",
            "initials": "FR",
            "lastname": "Zakka"
        },
        {
            "affiliation": "Eyelid Experts, Palm Beach Gardens, Florida, USA.",
            "firstname": "Peter A D",
            "initials": "PAD",
            "lastname": "Rubin"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1159/000488057",
    "journal": "Ocular oncology and pathology",
    "keywords": [
        "Acute megakaryoblastic leukemia",
        "Blast",
        "Chloroma",
        "Conjunctiva",
        "Granulocytic sarcoma",
        "JAK2",
        "Megakaryocyte",
        "Myelofibrosis",
        "Myeloid sarcoma",
        "Trisomy 8",
        "V617F mutation",
        "t(12; 17) translocation"
    ],
    "methods": null,
    "publication_date": "2019-01-25",
    "pubmed_id": "30675474\n20587614\n15002029\n1060381\n24556444\n27879987\n24118374\n22297536\n16642360\n17667120\n28986312\n22744397\n19166619\n1833041\n24962432\n17443224\n9722895\n29222292\n19890130\n20428194\n15902283\n25124313\n24058768\n26077631\n23556098",
    "results": null,
    "title": "Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva.",
    "xml": "<Element 'PubmedArticle' at 0x788506675d50>"
}