{
    "abstract": "To compare the accuracy of four published reference standards for the umbilical artery pulsatility index (UA-PI) in predicting small-for-gestational age (SGA), adverse neonatal outcomes and obstetric complications in pregnancies at risk for fetal growth restriction.\nThis was a secondary analysis of a prospective study of singleton pregnancies that underwent fetal growth assessment by ultrasound between 26 and 36\u2009weeks' gestation. Pregnancies with estimated fetal weight or abdominal circumference <\u200920\nOf the 1054 pregnancies that underwent fetal growth evaluation by ultrasound, 207 were included in our analysis. SGA, adverse neonatal outcomes and obstetric complications were diagnosed in 94 (45.4%), 50 (24.2%) and 69 (33.3%) cases, respectively. All reference standards had similar and statistically significant but poor predictive accuracy for SGA (AUC of 0.55 to 0.56), adverse neonatal outcomes (AUC of 0.57 to 0.60) and obstetric complications (AUC of 0.55 for all).\nThe reference standards for UA-PI evaluated herein have poor predictive ability for SGA, adverse neonatal outcomes and obstetric complications. At present, no particular UA-PI reference standard can be recommended over others. Larger trials are needed to answer this research question. \u00a9 2024 International Society of Ultrasound in Obstetrics and Gynecology.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.",
            "firstname": "J R",
            "initials": "JR",
            "lastname": "Duncan"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.",
            "firstname": "L E",
            "initials": "LE",
            "lastname": "Markel"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.",
            "firstname": "K",
            "initials": "K",
            "lastname": "Pressman"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.",
            "firstname": "A R",
            "initials": "AR",
            "lastname": "Rodriguez"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.",
            "firstname": "S G",
            "initials": "SG",
            "lastname": "Obican"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.\nDepartment of Obstetrics and Gynecology, School of Medicine, Washington University, St Louis, MO, USA.",
            "firstname": "A O",
            "initials": "AO",
            "lastname": "Odibo"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 International Society of Ultrasound in Obstetrics and Gynecology.",
    "doi": "10.1002/uog.29142",
    "journal": "Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology",
    "keywords": [
        "Doppler",
        "accuracy",
        "adverse neonatal outcomes",
        "fetal growth restriction",
        "obstetric complications",
        "reference standard",
        "small\u2010for\u2010gestational age",
        "umbilical artery"
    ],
    "methods": null,
    "publication_date": "2025-01-02",
    "pubmed_id": "39743627",
    "results": "Of the 1054 pregnancies that underwent fetal growth evaluation by ultrasound, 207 were included in our analysis. SGA, adverse neonatal outcomes and obstetric complications were diagnosed in 94 (45.4%), 50 (24.2%) and 69 (33.3%) cases, respectively. All reference standards had similar and statistically significant but poor predictive accuracy for SGA (AUC of 0.55 to 0.56), adverse neonatal outcomes (AUC of 0.57 to 0.60) and obstetric complications (AUC of 0.55 for all).",
    "title": "Comparison of umbilical artery pulsatility index reference ranges.",
    "xml": "<Element 'PubmedArticle' at 0x7885056f0a40>"
}