{
    "abstract": "In acute alkali corneal burns, the routine treatment protocol includes suppressing inflammation using corticosteroids. In recent years, there has been a growing interest in the role of insulin in wound healing research due to its remarkable positive effects.\nThe present study aimed to compare the healing effects of dexamethasone -the conventional approach- and NPH-insulin on alkali corneal burns.\nAn alkali corneal burn was created using Ca (OH)\nA more successful clinical recovery graph was drawn for group II. Particularly, a significant (P<0.05) improvement was detected in group II on day 21. The highest positivity in MMP-9 corneal staining was found in group I. Group II had a significant (P<0.05) increase in total antioxidant capacity (TAC) values. The treatment groups showed a significant (P<0.05) decrease in total oxidant content (TOC) values and a significant (P<0.05) increase in reduced glutathione (GSH) levels as compared with the control group.\nTopical NPH-insulin provided rapid and uncomplicated clinical recovery of alkali corneal burns. Insulin and dexamethasone showed similar effects like increased antioxidant molecules and decreased oxidant substances which indicated that insulin may prevent free radical formation in the cornea.",
    "authors": [
        {
            "affiliation": "Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.",
            "firstname": "B",
            "initials": "B",
            "lastname": "Kurt"
        },
        {
            "affiliation": "Department of Ophthalmology, Faculty of Medicine, Harran University, \u015eanl\u0131urfa, Turkey.",
            "firstname": "L",
            "initials": "L",
            "lastname": "Balyen"
        },
        {
            "affiliation": "Department of Chemistry, Faculty of Science and Letter, Kafkas University, Kars, Turkey.",
            "firstname": "O",
            "initials": "O",
            "lastname": "Ataki\u015fi"
        },
        {
            "affiliation": "Department of Histology and Embryology, Faculty of Medicine, Kafkas University, Kars, Turkey.",
            "firstname": "S",
            "initials": "S",
            "lastname": "Yi\u011fit"
        },
        {
            "affiliation": "Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.",
            "firstname": "U",
            "initials": "U",
            "lastname": "Aydin"
        },
        {
            "affiliation": "Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.",
            "firstname": "I",
            "initials": "I",
            "lastname": "\u00d6zaydin"
        }
    ],
    "conclusions": "Topical NPH-insulin provided rapid and uncomplicated clinical recovery of alkali corneal burns. Insulin and dexamethasone showed similar effects like increased antioxidant molecules and decreased oxidant substances which indicated that insulin may prevent free radical formation in the cornea.",
    "copyrights": null,
    "doi": "10.22099/ijvr.2024.47545.6867",
    "journal": "Iranian journal of veterinary research",
    "keywords": [
        "Corneal alkali burn",
        "Insulin",
        "Oxidative stress",
        "Rabbit",
        "Wound healing"
    ],
    "methods": null,
    "publication_date": "2024-01-01",
    "pubmed_id": "39925836\n2458030\n21982267\n36474571\n13967893\n31086244\n942051\n24488127\n22564234\n19948101\n30746908\n20467317\n31860766\n16307038\n33079994\n24810536\n21027052\n16604381\n36675574\n33767351\n12136400\n16405065\n32095203\n9748266\n10657750\n28412300\n32452924\n12617614\n24376903\n32982161\n32214835\n18249249\n22363499\n8082478",
    "results": "A more successful clinical recovery graph was drawn for group II. Particularly, a significant (P<0.05) improvement was detected in group II on day 21. The highest positivity in MMP-9 corneal staining was found in group I. Group II had a significant (P<0.05) increase in total antioxidant capacity (TAC) values. The treatment groups showed a significant (P<0.05) decrease in total oxidant content (TOC) values and a significant (P<0.05) increase in reduced glutathione (GSH) levels as compared with the control group.",
    "title": "Influence of topical NPH-insulin use on wound healing and oxidative stress in alkali corneal burns: an experimental study in a rabbit model.",
    "xml": "<Element 'PubmedArticle' at 0x788503cc71f0>"
}