{
    "abstract": "The rapid advancement of nanotechnology has opened new avenues for biomedical applications, particularly in antimicrobial, anti-inflammatory, and anticancer therapies. Green synthesis of zinc oxide nanoparticles (ZnO-NPs) using plant extracts offers an eco-friendly and biocompatible alternative to traditional chemical methods. This study explores the synthesis of ZnO-NPs using \nClove bud extract-zinc oxide nanoparticles (CBE-ZnO-NPs) were synthesized and characterized using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and Brunauer-Emmett-Teller (BET) analyses to confirm their size, morphology, elemental composition, and surface properties. The anticancer efficacy was tested against tongue carcinoma (HNO-97) cells using the sulforhodamine B (SRB) assay. Antibacterial activity was assessed against \nThe SEM analysis confirmed a non-uniform shape of ZnO-NPs, while FTIR revealed functional groups responsible for stabilization and bioactivity. DLS measurements indicated an average particle size of 249.8 nm with a zeta potential of -3.38 mV, ensuring moderate colloidal stability. BET analysis demonstrated a high porosity (30.039 m\u00b2/g) and a mean particle size of 19.52 nm. CBE-ZnO-NPs exhibited moderate anticancer activity against tongue carcinoma cells (IC\nThis study highlights the potential of CBE-ZnO-NPs as a promising multi-functional nanomaterial with potent antibacterial, anticancer, and anti-inflammatory properties. The findings pave the way for further exploration of ZnO-based nanotherapeutics in biomedical applications, particularly in cancer therapy, infection control, and inflammatory disorders.",
    "authors": [
        {
            "affiliation": "Department of Biology, College of Science, Taif University, Taif, 21944, Saudi Arabia.",
            "firstname": "Nahed Ahmed",
            "initials": "NA",
            "lastname": "Hussien"
        },
        {
            "affiliation": "Department of Biology, College of Science, Taif University, Taif, 21944, Saudi Arabia.",
            "firstname": "Maha Abd El Fattah",
            "initials": "MAEF",
            "lastname": "Khalil"
        },
        {
            "affiliation": "Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, A-1030, Austria.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Schagerl"
        },
        {
            "affiliation": "Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.",
            "firstname": "Sameh Samir",
            "initials": "SS",
            "lastname": "Ali"
        }
    ],
    "conclusions": "This study highlights the potential of CBE-ZnO-NPs as a promising multi-functional nanomaterial with potent antibacterial, anticancer, and anti-inflammatory properties. The findings pave the way for further exploration of ZnO-based nanotherapeutics in biomedical applications, particularly in cancer therapy, infection control, and inflammatory disorders.",
    "copyrights": "\u00a9 2025 Hussien et al.",
    "doi": "10.2147/IJN.S507214\n10.3389/fmicb.2021.705673\n10.1016/j.biortech.2022.128308\n10.3389/fmicb.2021.648560\n10.1016/j.scitotenv.2021.148359\n10.1016/j.eti.2022.102336\n10.2147/IJN.S141201\n10.1016/j.foodcont.2023.110117\n10.1016/j.micpath.2020.104164\n10.1016/j.ijfoodmicro.2021.109116\n10.1016/j.micpath.2023.106375\n10.1039/d1na00880c\n10.1515/ntrev-2023-0112\n10.3390/microorganisms9102041\n10.1016/j.scitotenv.2022.159278\n10.1016/j.biopha.2023.116083\n10.3390/biom10020202\n10.3389/fnut.2022.1002147\n10.3390/ma17174340\n10.1016/j.rechem.2024.101783\n10.1039/C8TX00267C\n10.1016/j.molstruc.2024.138545\n10.1186/s11671-020-03418-6\n10.3390/pharmaceutics13101662\n10.1016/j.jconrel.2022.05.035\n10.3390/jnt4030012\n10.1007/s11033-024-09407-7\n10.1016/j.identj.2024.03.017\n10.1016/j.msec.2016.01.039\n10.1371/journal.pone.0198943\n10.1186/s10020-022-00530-4\n10.3390/su15119048\n10.3390/molecules27041236\n10.3390/su15139864\n10.3390/nano11010095\n10.18805/IJAR.BF-1808\n10.1016/j.biteb.2021.100753\n10.1515/gps-2022-0083\n10.1155/2009/968058\n10.3390/ma15155169\n10.3390/molecules26144326\n10.1093/jnci/82.13.1107\n10.1016/j.toxlet.2018.04.008\n10.1093/ndt/14.10.2433\n10.1016/j.bioorg.2022.106171\n10.1080/13880200500530765\n10.1016/j.foodchem.2016.07.101\n10.15430/JCP.2014.19.4.288\n10.1007/s00449-014-1205-6\n10.1007/s00449-013-0994-3\n10.1006/jcis.2002.8664\n10.1016/j.cap.2010.07.030\n10.1016/j.apt.2016.03.014\n10.3390/catal12111347\n10.1002/adma.201970226\n10.1186/s12866-024-03392-4\n10.24071/jpsc.142728\n10.1021/jf010964p\n10.3390/antiox11081444\n10.17344/acsi.2018.4213\n10.1016/j.sdentj.2023.07.021\n10.3390/cancers13184570\n10.1515/msp-2017-0007\n10.1016/j.chemosphere.2024.142826\n10.3390/molecules27238367\n10.1007/s10856-008-3541-z\n10.1088/0957-4484/19/29/295103\n10.3390/biom10010038\n10.3390/ijms24065677\n10.3390/nano10020292\n10.1080/87559129.2020.1737709\n10.3389/fchem.2020.00580\n10.1002/pat.5660\n10.1155/2023/3280708\n10.3390/molecules28227619\n10.1186/s11671-018-2532-3\n10.18433/J3B897\n10.2217/nnm.15.45\n10.1016/j.jphotobiol.2015.02.008",
    "journal": "International journal of nanomedicine",
    "keywords": [
        "Syzygium aromaticum",
        "biomedical applications",
        "green synthesis",
        "nanotechnology",
        "zinc oxide nanoparticles"
    ],
    "methods": null,
    "publication_date": "2025-04-14",
    "pubmed_id": "40225223\n35211096\n36370936\n34616370\n34147795\n28860766\n32198092\n33676332\n37774989\n36133407\n34683362\n36216068\n38163395\n32019140\n36313111\n39274730\n39916856\n30997024\n33001404\n34683954\n35644289\n38489102\n38679518\n26952399\n29889899\n36058911\n35209025\n33406606\n35897601\n34299601\n2359136\n29654831\n10528669\n36166898\n27507495\n27802299\n25574464\n24842223\n23771163\n12702369\n31148285\n38982372\n11879046\n35892646\n33562923\n38107049\n11356986\n34572797\n39002651\n36500466\n18651111\n18836572\n31888037\n36982751\n32050443\n32793554\n37082193\n38005341\n29740719\n27806251\n26084368\n25777265",
    "results": "The SEM analysis confirmed a non-uniform shape of ZnO-NPs, while FTIR revealed functional groups responsible for stabilization and bioactivity. DLS measurements indicated an average particle size of 249.8 nm with a zeta potential of -3.38 mV, ensuring moderate colloidal stability. BET analysis demonstrated a high porosity (30.039 m\u00b2/g) and a mean particle size of 19.52 nm. CBE-ZnO-NPs exhibited moderate anticancer activity against tongue carcinoma cells (IC",
    "title": "Green Synthesis of Zinc Oxide Nanoparticles as a Promising Nanomedicine Approach for Anticancer, Antibacterial, and Anti-Inflammatory Therapies.",
    "xml": "<Element 'PubmedArticle' at 0x788505d4fe20>"
}