{
    "abstract": "Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension with a low incidence. Despite pulmonary endarterectomy(PEA) being the preferred treatment for CTEPH, for patients who failed medical therapy and who are not suitable candidates for PEA, lung transplantation (LT) is still the only effective treatment for end-stage CTEPH; however, there are currently very few reports on the efficacy of LT for CTEPH.\nWe retrospectively analyzed the clinical data of seven patients diagnosed with CTEPH between July 2019 and July 2021. The follow-up deadline was March, 2022.\nThe mean age at admission was 54\u2009\u00b1\u200912 years. The average value of mean pulmonary artery pressure (mPAP) was 40\u2009\u00b1\u20095 mmHg. The mean preoperative oxygenation index(PaO2/FiO2) was 203\u2009\u00b1\u200956\u00a0mm Hg. After evaluation, one patient underwent left LT and the rest underwent bilateral LT. Three patients received intraoperative veno-venous extracorporeal membrane oxygenation (ECMO) support, and four patients received intraoperative veno-arterial ECMO support. The average postoperative mPAP was 19\u2009\u00b1\u20094 mmHg. The mean postoperative oxygenation index(PaO2/FiO2) was 388\u2009\u00b1\u200983 mmHg. There was a significant difference between the preoperative and postoperative mPAP and oxygenation index(PaO2/FiO2). All patients recovered well and were discharged 37\u2009\u00b1\u200919 days postoperatively. The mean follow-up duration was 19\u2009\u00b1\u20098 months. There was no recurrence of CTEPH.\nLT is an effective treatment for end-stage CTEPH, which can improve cardiopulmonary function and quality of life and prolong survival. Patients who are unable to tolerate PEA should be considered for LT as early as possible when internal medicine failed.",
    "authors": [
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.",
            "firstname": "Yuan",
            "initials": "Y",
            "lastname": "Chen"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.",
            "firstname": "Jialong",
            "initials": "J",
            "lastname": "Liang"
        },
        {
            "affiliation": "The Taihu Rehabilitation Hospital of Jiangsu Province (The Taihu Sanatorium of Jiangsu Province), Wuxi, Jiangsu, China.",
            "firstname": "Qian",
            "initials": "Q",
            "lastname": "Li"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.",
            "firstname": "Jintao",
            "initials": "J",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.",
            "firstname": "Jian",
            "initials": "J",
            "lastname": "Xu"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.",
            "firstname": "Dian",
            "initials": "D",
            "lastname": "Xiong"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.",
            "firstname": "Huachi",
            "initials": "H",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China. ysg206@hotmail.com.",
            "firstname": "Shugao",
            "initials": "S",
            "lastname": "Ye"
        },
        {
            "affiliation": "Wuxi Lung Transplant Center, Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China. chenjy@wuxiph.com.",
            "firstname": "Jingyu",
            "initials": "J",
            "lastname": "Chen"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s12890-024-03213-4\n10.1093/eurheartj/ehv317\n10.1016/S2213-2600(15)00543-3\n10.1016/j.hfc.2018.02.009\n10.1097/CRD.0000000000000164\n10.21037/atm.2019.10.26\n10.1160/TH16-10-0790\n10.14797/IQTU6714\n10.1164/rccm.200912-1951OC\n10.1183/09031936.00041411\n10.1007/s12015-020-10043-4\n10.1016/S2213-2600(14)70089-X\n10.21037/acs-2021-pte-12\n10.1513/AnnalsATS.201601-014AS",
    "journal": "BMC pulmonary medicine",
    "keywords": [
        "Chronic thromboembolic pulmonary hypertension",
        "Extracorporeal membrane oxygenation",
        "Lung transplantation",
        "Pulmonary endarterectomy",
        "Pulmonary fibrosis"
    ],
    "methods": null,
    "publication_date": "2024-08-27",
    "pubmed_id": "39187801\n26318161\n26975810\n29966632\n28832374\n16818116\n32154286\n28150849\n34377353\n20167844\n21737559\n32970229\n24898750\n35433370\n27571005",
    "results": "The mean age at admission was 54\u2009\u00b1\u200912 years. The average value of mean pulmonary artery pressure (mPAP) was 40\u2009\u00b1\u20095 mmHg. The mean preoperative oxygenation index(PaO2/FiO2) was 203\u2009\u00b1\u200956\u00a0mm Hg. After evaluation, one patient underwent left LT and the rest underwent bilateral LT. Three patients received intraoperative veno-venous extracorporeal membrane oxygenation (ECMO) support, and four patients received intraoperative veno-arterial ECMO support. The average postoperative mPAP was 19\u2009\u00b1\u20094 mmHg. The mean postoperative oxygenation index(PaO2/FiO2) was 388\u2009\u00b1\u200983 mmHg. There was a significant difference between the preoperative and postoperative mPAP and oxygenation index(PaO2/FiO2). All patients recovered well and were discharged 37\u2009\u00b1\u200919 days postoperatively. The mean follow-up duration was 19\u2009\u00b1\u20098 months. There was no recurrence of CTEPH.",
    "title": "Clinical outcome of lung transplantation for chronic thromboembolic pulmonary hypertension.",
    "xml": "<Element 'PubmedArticle' at 0x78850300e020>"
}