{
    "abstract": "Chronic endometritis (CE) contributes to impaired endometrial receptivity and is closely associated with poor \nThis retrospective study involved 15 fertile women and 77 infertile patients diagnosed with CE based on CD138+ \u22651/10 high-power fields (HPFs). The CE patients were divided into Group 1 (CD138+ 1-4/10 HPFs, 53 cases) and Group 2 (CD138+ \u22655/10 HPFs, 24 cases). The expression levels of hypoxia-inducible factor 1\u03b1 (HIF1\u03b1), vascular endothelial growth factor A (VEGFA), and vascular endothelial growth factor receptor 2 (VEGFR2) in peri-implantation endometrium were assessed by qRT-PCR and western blot analyses. Spatial levels of HIF1\u03b1, VEGFA, and VEGFR2 in various endometrial compartments was determined using immunohistochemistry and \nRelative to Group 1 and control group, during the implantation window, protein and mRNA levels of HIF1\u03b1, VEGFA, and VEGFR2 were markedly high in Group 2 (\nHere, we for the first time report the upregulation of HIF1\u03b1, VEGFA, and VEGFR2, as well as excessive endometrial vascularization in the peri-implantation endometrium of CE patients. Our findings offer new insights into reduced endometrial receptivity in CE-associated infertility.",
    "authors": [
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Zhenteng",
            "initials": "Z",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Xuemei",
            "initials": "X",
            "lastname": "Liu"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Fenghua",
            "initials": "F",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Yuxia",
            "initials": "Y",
            "lastname": "Sun"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Lili",
            "initials": "L",
            "lastname": "Yu"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Ping",
            "initials": "P",
            "lastname": "Zhu"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Ding",
            "initials": "D",
            "lastname": "Ma"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Xinrong",
            "initials": "X",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Shoucui",
            "initials": "S",
            "lastname": "Lai"
        },
        {
            "affiliation": "Department of Reproductive Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.",
            "firstname": "Hongchu",
            "initials": "H",
            "lastname": "Bao"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2022 Liu, Liu, Li, Sun, Yu, Zhang, Zhu, Ma, Wang, Lai and Bao.",
    "doi": "10.3389/fendo.2022.1001437\n10.1016/j.fertnstert.2021.01.018\n10.5114/pm.2020.97863\n10.1016/0002-9378(83)90045-5\n10.1016/j.ajog.2018.02.012\n10.1111/aji.13369\n10.1016/j.fertnstert.2008.12.131\n10.1111/aji.12277\n10.1016/j.fertnstert.2018.01.022\n10.1016/j.fertnstert.2013.12.031\n10.1016/j.fertnstert.2015.06.044\n10.1016/j.fertnstert.2015.09.025\n10.1111/aji.13357\n10.1093/humrep/deu292\n10.1111/aji.12719\n10.1016/j.rbmo.2017.09.008\n10.1038/modpathol.2010.98\n10.1016/j.fertnstert.2019.09.001\n10.1111/aji.12076\n10.3390/diagnostics11030471\n10.1186/s12958-017-0233-x\n10.1186/s12958-018-0444-9\n10.1002/iid3.354\n10.1111/aji.12693\n10.1007/978-1-4615-4711-2_20\n10.1172/JCI22991\n10.1210/en.2005-1153\n10.1016/s0006-2952(99)00292-0\n10.3892/mmr.2017.7890\n10.3390/biom11020253\n10.1016/j.rbmo.2010.07.005\n10.1093/humrep/dei239\n10.1016/j.fertnstert.2012.08.006\n10.1016/j.fertnstert.2015.06.021\n10.1016/j.fertnstert.2019.03.004\n10.1016/j.fertnstert.2021.03.036\n10.1016/j.fertnstert.2017.05.016\n10.1016/j.fertnstert.2016.11.008\n10.1016/j.fertnstert.2016.02.032\n10.1172/JCI98931\n10.1177/1933719113508817\n10.1007/s00404-013-3131-2\n10.1016/j.fertnstert.2018.03.017",
    "journal": "Frontiers in endocrinology",
    "keywords": [
        "VEGFA",
        "chronic endometritis",
        "endometrial receptivity",
        "endometrial vascularization",
        "hypoxia-inducible factor 1\u03b1",
        "in vitro fertilization",
        "infertility"
    ],
    "methods": null,
    "publication_date": "2022-12-20",
    "pubmed_id": "36531509\n33722376\n32802019\n6359886\n29477653\n33152123\n19217098\n24898900\n29778382\n24462055\n26207958\n26456229\n33020952\n25385744\n28608596\n29111313\n20495539\n31718829\n23351011\n33800186\n28259137\n30606202\n32969185\n28466568\n10635006\n15372095\n16282352\n10605934\n29115598\n33578823\n21050818\n16085661\n22959454\n26143364\n31104760\n33926717\n28624114\n27939762\n27018158\n1635745\n29911998\n24177713\n24395012\n29908776",
    "results": "Relative to Group 1 and control group, during the implantation window, protein and mRNA levels of HIF1\u03b1, VEGFA, and VEGFR2 were markedly high in Group 2 (",
    "title": "Overexpression of hypoxia-inducible factor 1\u03b1 and excessive vascularization in the peri-implantation endometrium of infertile women with chronic endometritis.",
    "xml": "<Element 'PubmedArticle' at 0x788504595b70>"
}