{
    "abstract": "Radiation safety-related data of 31 patients who underwent 177Lu-DOTATATE intra-arterial PRRT treatment were used for this study. The exposure rate was measured at the hand and eye and chest level of treating intervention radiologists continuously from the beginning to the end of the administration. Exposure from the patient at the body surface (at the level of liver, thigh, and extremities) and 1 m from the body surface was measured just after the administration. The mean radiation exposure from the patient at the body surface and 1 m from the body was also calculated.\nThe mean administered activity was found to be 194 (\u00b117) mCi. The mean radiation exposure at the surface at the level of the liver, thigh, and feet and at 1 m from the surface was found to be 100 (\u00b125.11), 9 (\u00b11.27), 5.6 (\u00b10.52), and 5.3\u00b1 (0.50) \u03bcSv/hr, respectively. The mean administration time was found to be 23 \u00b1 5.6 min. The mean radiation dose to the hands, and eyes, of the treating intervention radiologist per procedure, was found to be 6.425 \u00b1 2.75 \u03bcSv, 5.43 \u00b1 1.76 \u03bcSv and 1-m exposure from the patient was found to be 5.3 \u00b1 0.246 \u03bcSv, respectively.\nOur result shows that the radiation exposure from the patient postadministration is below the permissible limit of discharge. The radiation exposure to the intervention radiologist is also suggestive of a safe procedure to be performed by maintaining the radiation dose well within the permissible limit for radiation professionals.",
    "authors": [
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra, India.\nDepartment of Radiology, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.",
            "firstname": "Manoj Kumar Hariram",
            "initials": "MKH",
            "lastname": "Chauhan"
        },
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Ashish Kumar",
            "initials": "AK",
            "lastname": "Jha"
        },
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Sneha",
            "initials": "S",
            "lastname": "Mithun"
        },
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Rutuja Dasharath",
            "initials": "RD",
            "lastname": "Parab"
        },
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra, India.\nDepartment of Radiology, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.",
            "firstname": "Pooja",
            "initials": "P",
            "lastname": "Dwivedi"
        },
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Ameya D",
            "initials": "AD",
            "lastname": "Puranik"
        },
        {
            "affiliation": "Department of Radiology, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Kunal Bharat",
            "initials": "KB",
            "lastname": "Gala"
        },
        {
            "affiliation": "Department of Radiology, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Nitin Sudhakar",
            "initials": "NS",
            "lastname": "Shetye"
        },
        {
            "affiliation": "Department of Radiology, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Suyash",
            "initials": "S",
            "lastname": "Kulkarni"
        },
        {
            "affiliation": "Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra, India.\nDepartment of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India.\nHomi Bhabha National Institute, Mumbai, Maharashtra, India.",
            "firstname": "Venkatesh",
            "initials": "V",
            "lastname": "Rangarajan"
        }
    ],
    "conclusions": "Our result shows that the radiation exposure from the patient postadministration is below the permissible limit of discharge. The radiation exposure to the intervention radiologist is also suggestive of a safe procedure to be performed by maintaining the radiation dose well within the permissible limit for radiation professionals.",
    "copyrights": "Copyright: \u00a9 2024 Indian Journal of Nuclear Medicine.",
    "doi": "10.4103/ijnm.ijnm_88_23",
    "journal": "Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India",
    "keywords": [
        "177Lu",
        "177Lu-DOTATATE",
        "intra-arterial",
        "neuroendocrine tumor",
        "peptide receptor therapy"
    ],
    "methods": null,
    "publication_date": "2025-01-10",
    "pubmed_id": "39790832\n23237225\n28385820\n34944626\n29942399\n26085854\n32819499\n29333565\n36622501\n29651569\n26420990\n25400361\n31025215\n37038926\n30260854\n36508552\n32513903\n27039186\n37383534\n33608483",
    "results": "The mean administered activity was found to be 194 (\u00b117) mCi. The mean radiation exposure at the surface at the level of the liver, thigh, and feet and at 1 m from the surface was found to be 100 (\u00b125.11), 9 (\u00b11.27), 5.6 (\u00b10.52), and 5.3\u00b1 (0.50) \u03bcSv/hr, respectively. The mean administration time was found to be 23 \u00b1 5.6 min. The mean radiation dose to the hands, and eyes, of the treating intervention radiologist per procedure, was found to be 6.425 \u00b1 2.75 \u03bcSv, 5.43 \u00b1 1.76 \u03bcSv and 1-m exposure from the patient was found to be 5.3 \u00b1 0.246 \u03bcSv, respectively.",
    "title": "Radiation Safety Assessment of 177Lu-DOTATATE Intra-arterial Peptide Receptor Therapy (PRRT).",
    "xml": "<Element 'PubmedArticle' at 0x7885031a2ca0>"
}