{
    "abstract": "To evaluate the effect of laparoscopic procedures integrated with traditional Chinese medicine (TCM), specifically aimed at enhancing blood flow and alleviating blood stasis, on oxidative stress levels in individuals with endometriosis-induced infertility.\nWe performed a systematic quantitative review to evaluate the effects of laparoscopic surgery combined with TCM on oxidative stress in endometriosis-related infertility by enhancing blood circulation and resolving stasis. A literature search of 9 major databases was performed. Meta-analysis was performed using Review Manager version 5.4 (R Foundation for Statistical Computing, Vienna, Austria) and Stata Release 16.0 (StataCorp LLC, College Station, TX). This systematic review was registered with the International Prospective Register of Systematic Reviews (i.e., \"PROSPERO\") (registration number: CRD42024526800).\nThirteen trials comprising 1084 participants were included. Laparoscopy combined with TCM for promoting blood circulation and removing blood stasis significantly reduced the levels of 8-isoprostane prostaglandin F2\u03b1 (mean difference [MD] -29.57 [95% confidence interval (CI) -32.65 to -26.49]; P\u2005<\u2005.001), regulated on activation, normal T cell expressed and secreted (MD -231.83 [95% CI -341.33 to -122.32]; P\u2005<\u2005.001), reactive oxygen species (MD -0.92; [95% CI -1.12 to -0.73]; P\u2005<\u2005.001), monocyte chemoattractant protein-1 (MD -31.23 [95% CI -42.70 to -19.77]; P\u2005<\u2005.001), and increased glutathione peroxidase (MD 31.45 [95% CI 26.04 to 36.87]; P\u2005<\u2005.001), vitamin E (MD 4.86 [95% CI 3.77 to 5.94]; P\u2005<\u2005.001), superoxide dismutase (standardized MD 0.92 [95% CI 0.41 to 1.42]; P\u2005<\u2005.001).\nCompared with laparoscopic surgery alone, the combination of TCM for promoting blood circulation and removing blood stasis demonstrated the potential to ameliorate oxidative stress in patients with endometriosis-induced infertility. However, further large-scale clinical trials are required to confirm these findings.",
    "authors": [
        {
            "affiliation": "Community Health Service Center, Wanqingsha Town, Nansha District, Guangzhou City, Guangdong Province, China.",
            "firstname": "Shaoqiao",
            "initials": "S",
            "lastname": "Lin"
        },
        {
            "affiliation": "Zhuhai Xiangzhou District People's Hospital, Zhuhai City, Guangdong Province, China.",
            "firstname": "Shanshan",
            "initials": "S",
            "lastname": "Zhou"
        }
    ],
    "conclusions": "Compared with laparoscopic surgery alone, the combination of TCM for promoting blood circulation and removing blood stasis demonstrated the potential to ameliorate oxidative stress in patients with endometriosis-induced infertility. However, further large-scale clinical trials are required to confirm these findings.",
    "copyrights": "Copyright \u00a9 2025 the Author(s). Published by Wolters Kluwer Health, Inc.",
    "doi": "10.1097/MD.0000000000041692",
    "journal": "Medicine",
    "keywords": [
        "endometriosis-related infertility",
        "oxidative stress",
        "traditional Chinese medicine"
    ],
    "methods": null,
    "publication_date": "2025-04-14",
    "pubmed_id": "40228263\n35163463\n32019326\n38658503\n29743986\n30017581\n30625295\n36835217\n29493042\n25560108\n34689247\n34401644\n29077705\n31260048\n22008217\n34194012\n29057034\n27100482\n29958140\n25376454\n31846434\n34121193\n31972508\n33930149\n33533416\n31540845\n30377403\n31586810\n34122682\n36826028\n22748101\n22578534\n16978905\n20692336",
    "results": "Thirteen trials comprising 1084 participants were included. Laparoscopy combined with TCM for promoting blood circulation and removing blood stasis significantly reduced the levels of 8-isoprostane prostaglandin F2\u03b1 (mean difference [MD] -29.57 [95% confidence interval (CI) -32.65 to -26.49]; P\u2005<\u2005.001), regulated on activation, normal T cell expressed and secreted (MD -231.83 [95% CI -341.33 to -122.32]; P\u2005<\u2005.001), reactive oxygen species (MD -0.92; [95% CI -1.12 to -0.73]; P\u2005<\u2005.001), monocyte chemoattractant protein-1 (MD -31.23 [95% CI -42.70 to -19.77]; P\u2005<\u2005.001), and increased glutathione peroxidase (MD 31.45 [95% CI 26.04 to 36.87]; P\u2005<\u2005.001), vitamin E (MD 4.86 [95% CI 3.77 to 5.94]; P\u2005<\u2005.001), superoxide dismutase (standardized MD 0.92 [95% CI 0.41 to 1.42]; P\u2005<\u2005.001).",
    "title": "Impact of combining laparoscopy with traditional Chinese medicine on oxidative stress in endometriosis-related infertility: A systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x7885060794e0>"
}