{
    "abstract": "The response of ryanodine receptor (RyR) channels to increases in free cytoplasmic calcium concentration ([Ca",
    "authors": [
        {
            "affiliation": "Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Facultad de Medicina-Hospital Cl\u00ednico, Universidad de Chile, Santiago 8380453, Chile.",
            "firstname": "Jamileth",
            "initials": "J",
            "lastname": "More"
        },
        {
            "affiliation": "Physiology and Biophysics Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago 8380453, Chile.",
            "firstname": "Jos\u00e9 Pablo",
            "initials": "JP",
            "lastname": "Finkelstein"
        },
        {
            "affiliation": "Faculty of Medicine, Biomedical Neuroscience Institute, Universidad de Chile, Santiago 8380453, Chile.",
            "firstname": "Jos\u00e9 Luis",
            "initials": "JL",
            "lastname": "Vald\u00e9s"
        },
        {
            "affiliation": "Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.",
            "firstname": "Cecilia",
            "initials": "C",
            "lastname": "Hidalgo"
        },
        {
            "affiliation": "Physiology and Biophysics Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago 8380453, Chile.",
            "firstname": "Ricardo",
            "initials": "R",
            "lastname": "Bull"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ijms26052101\n10.1016/j.biochi.2021.12.002\n10.1016/j.molmed.2023.10.008\n10.1016/S0092-8674(00)00054-4\n10.1074/jbc.M007613200\n10.1089/ars.2000.2.1-17\n10.1080/15216540500092328\n10.1074/jbc.M600876200\n10.4067/S0716-97602002000200009\n10.1016/S0006-3495(00)76290-4\n10.1074/jbc.M306969200\n10.1016/j.yjmcc.2005.08.010\n10.1016/j.yjmcc.2013.12.028\n10.1073/pnas.1013580108\n10.1089/ars.2017.7277\n10.3389/fnagi.2017.00111\n10.1152/physiol.00038.2015\n10.1016/0014-5793(96)00222-0\n10.1016/S0006-3495(98)77840-3\n10.1152/ajpcell.00296.2002\n10.1152/ajpcell.00518.2006\n10.3389/fnagi.2018.00399\n10.1523/JNEUROSCI.2286-08.2008\n10.1016/S0304-3940(97)13349-3\n10.1111/j.1471-4159.2004.02711.x\n10.1161/01.STR.0000153069.96296.fd\n10.1016/j.freeradbiomed.2005.08.040\n10.1089/ars.2008.2063\n10.1016/j.ceca.2006.10.001\n10.1523/JNEUROSCI.14-08-04794.1994\n10.1016/j.bbrc.2022.10.024\n10.1002/hipo.20056",
    "journal": "International journal of molecular sciences",
    "keywords": [
        "RyR oxidation",
        "aging",
        "antioxidants",
        "calcium signaling",
        "spatial memory training",
        "thiol modification"
    ],
    "methods": null,
    "publication_date": "2025-03-13",
    "pubmed_id": "40076722\n34890732\n37957056\n10966111\n10952995\n11232595\n16036616\n17071618\n12415735\n10866954\n12920114\n16242147\n24417961\n21282625\n29357673\n28484388\n27053734\n8612791\n9512024\n12637263\n17360812\n30574085\n18799678\n9111736\n15447666\n15637315\n16443153\n18479206\n17074386\n8046450\n36344175\n15523608",
    "results": null,
    "title": "Aging Favors Calcium Activation of Ryanodine Receptor Channels from Brain Cortices and Hippocampi and Hinders Learning and Memory in Male Rats.",
    "xml": "<Element 'PubmedArticle' at 0x78850538bce0>"
}