{
    "abstract": "N-acetylcysteine (NAC) has antioxidant effects in reducing acute kidney injury. This study systematically reviewed and assessed the efficacy of NAC in preventing antimicrobials induced nephrotoxicity.\nPubmed, Embase, Web of Science, and the Cochrane Library were searched extensively for relevant studies that evaluating NAC on antimicrobials induced nephrotoxicity until June 1, 2024. Eligible records were screened according to the inclusion and exclusion criteria. The odds ratio (OR) was selected to evaluate the effect of NAC on nephrotoxicity. We pooled the extracted data using a random effects model.\nThree randomized controlled trials were included in the analysis. The pooled results showed that NAC could reduce the incidence of antimicrobials induced nephrotoxicity (OR\u2009=\u20090.487, 95% CI\u2009=\u20090.258, 0.918, P\u2009=\u20090.03, I\nIn this meta-analysis, NAC was associated with a benefit in the prevention of antimicrobials induced nephrotoxicity. However, large-scaled and well-designed RCTs are required in the future.",
    "authors": [
        {
            "affiliation": "Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.",
            "firstname": "Xianming",
            "initials": "X",
            "lastname": "Qiu"
        },
        {
            "affiliation": "Jining Medical University, Jining, Shandong, China.",
            "firstname": "Shenao",
            "initials": "S",
            "lastname": "Yang"
        },
        {
            "affiliation": "Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.",
            "firstname": "Yuke",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.",
            "firstname": "Quanzhen",
            "initials": "Q",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Emergency Center, Shandong University of Traditional Chinese Medicine Affiliated Hospital, No. 42, Wenhua West Road, Jinan, Shandong, 250014, China. zykl1@126.com.",
            "firstname": "Li",
            "initials": "L",
            "lastname": "Kong"
        },
        {
            "affiliation": "Department of Emergency Center, Shandong University of Traditional Chinese Medicine Affiliated Hospital, No. 42, Wenhua West Road, Jinan, Shandong, 250014, China. lily_zhoulei@126.com.",
            "firstname": "Lei",
            "initials": "L",
            "lastname": "Zhou"
        }
    ],
    "conclusions": "In this meta-analysis, NAC was associated with a benefit in the prevention of antimicrobials induced nephrotoxicity. However, large-scaled and well-designed RCTs are required in the future.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s12882-025-04037-y\n10.1101/2022.04.13.488126v2",
    "journal": "BMC nephrology",
    "keywords": [
        "Antimicrobials",
        "Meta-analysis",
        "N-acetylcysteine",
        "Nephrotoxicity"
    ],
    "methods": null,
    "publication_date": "2025-03-09",
    "pubmed_id": "40057704\n34605781\n38385751\n24717459\n35389144\n31291842\n37861206\n32146999\n38025228\n35655853\n30439416\n38800015\n35788669\n23508666\n35814787\n25555855\n31462531\n8721797\n17060756\n26050706\n24445685\n32536177\n35769842\n25317932\n37378746\n37946280\n35641849\n16011448\n38104745\n15083766\n38068931\n38770316\n20845026\n31618189\n38004033\n39094650\n38785564\n30035652\n29849877",
    "results": "Three randomized controlled trials were included in the analysis. The pooled results showed that NAC could reduce the incidence of antimicrobials induced nephrotoxicity (OR\u2009=\u20090.487, 95% CI\u2009=\u20090.258, 0.918, P\u2009=\u20090.03, I",
    "title": "Effect of N-acetylcysteine on antimicrobials induced nephrotoxicity: a meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788506aadee0>"
}