{
    "abstract": "Adult-type granulosa cell tumors (AGCTs), which account for 2% to 5% of all malignant ovarian tumors, are rare sex cord-stromal tumors that usually secrete excess estrogens, but they can also secrete androgens.\nWe report 2 patients of childbearing age with AGCT who presented with the complaint of abnormal menstruation and elevated luteinizing hormone (LH), and mildly elevated testosterone.\nThe ovarian tumors had hormonal activity.\nThe 2 patients underwent laparoscopic left adnexectomy. The second patient underwent 4 cycles of chemotherapy with paclitaxel and carboplatin as adjuvant treatments.\nTheir postoperative pathology confirmed AGCTs. Also, their menstrual cycle returned to normal, with normal serum LH and testosterone levels. There was no sign of recurrence.\nThe cases suggest that elevated serum LH levels may be a sign of unknown tumors in cases of oligomenorrhea or secondary amenorrhea. It is useful to evaluate the serum levels of inhibin B and anti-M\u00fcllerian hormone to improve the early recognition of ovarian granulosa cell tumors.",
    "authors": [
        {
            "affiliation": "Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.",
            "firstname": "Yujing",
            "initials": "Y",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.",
            "firstname": "Na",
            "initials": "N",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.",
            "firstname": "Xuejiao",
            "initials": "X",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.",
            "firstname": "Zijie",
            "initials": "Z",
            "lastname": "Fu"
        },
        {
            "affiliation": "Department of Pathology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.",
            "firstname": "Chao",
            "initials": "C",
            "lastname": "Pang"
        },
        {
            "affiliation": "Department of Gynecology, The Second Hospital of Hebei Medical University, 050004, Shijiazhuang, China.",
            "firstname": "Yuan",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.",
            "firstname": "Xiaodong",
            "initials": "X",
            "lastname": "Li"
        }
    ],
    "conclusions": "The cases suggest that elevated serum LH levels may be a sign of unknown tumors in cases of oligomenorrhea or secondary amenorrhea. It is useful to evaluate the serum levels of inhibin B and anti-M\u00fcllerian hormone to improve the early recognition of ovarian granulosa cell tumors.",
    "copyrights": "Copyright \u00a9 2024 the Author(s). Published by Wolters Kluwer Health, Inc.",
    "doi": "10.1097/MD.0000000000037069",
    "journal": "Medicine",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-02-16",
    "pubmed_id": "38363935\n34411449\n29275930\n36119817\n31499493\n12940239\n22583337\n36367302\n28438188\n34441035\n36922845\n17566848\n2770810\n22235403\n11070112\n36075393",
    "results": null,
    "title": "Adult-type granulosa cell tumor associated with elevated luteinizing hormone: Two rare case reports.",
    "xml": "<Element 'PubmedArticle' at 0x788504413c40>"
}