{
    "abstract": "Rapidly progressive glomerulonephritis (RPGN) is a syndrome characterized by a swift decline in kidney function, often over a few months, accompanied by features of nephritic syndrome. It can result in decreased urine output and commonly involves the presence of extensive crescents in kidney biopsies. RPGN is classified into 3 main types based on immune deposit distribution and visualization through immunofluorescence and electron microscopy: antiglomerular basement membrane disease, immune complex glomerulonephritis, and pauci-immune glomerulonephritis. Early diagnosis and prompt treatment are critical to prevent progression to ESRD. Standard treatment options for RPGN include glucocorticoids, cyclophosphamide, or rituximab, with plasma exchange especially important for antiglomerular basement membrane disease and select cases of ANCA-associated vasculitis. Clinical trials for glomerular diseases have primarily excluded patients with RPGN or dialysis dependence. Establishment of clinical registries is required for the optimization of therapeutic protocols for the treatment of RPGN.",
    "authors": [
        {
            "affiliation": "Johns Hopkins University School of Medicine, Baltimore, MD.",
            "firstname": "Abbal",
            "initials": "A",
            "lastname": "Koirala"
        },
        {
            "affiliation": "Zucker School of Medicine at Hofstra/Northwell, Medicine, Great Neck, NY.",
            "firstname": "Purva D",
            "initials": "PD",
            "lastname": "Sharma"
        },
        {
            "affiliation": "Zucker School of Medicine at Hofstra/Northwell, Medicine, Great Neck, NY.",
            "firstname": "Kenar D",
            "initials": "KD",
            "lastname": "Jhaveri"
        },
        {
            "affiliation": "University of North Carolina, Chapel Hill, NC.",
            "firstname": "Koyal",
            "initials": "K",
            "lastname": "Jain"
        },
        {
            "affiliation": "Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: dgeetha1@jhmi.edu.",
            "firstname": "Duvuru",
            "initials": "D",
            "lastname": "Geetha"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1053/j.akdh.2024.08.006",
    "journal": "Advances in kidney disease and health",
    "keywords": [],
    "methods": null,
    "publication_date": "2024-11-23",
    "pubmed_id": "39577882",
    "results": null,
    "title": "Rapidly Progressive Glomerulonephritis.",
    "xml": "<Element 'PubmedArticle' at 0x788502b28540>"
}