{
    "abstract": "Spider venoms contain many functional proteins/peptides such as proteinases, serine/cysteine proteinase inhibitors, insecticidal toxins, and ion channel toxins. However, to date, no peptide toxin with procoagulant activities has been identified from spider venom. In this study, a novel toxin LCTX-F2 with coagulation-promoting activity was identified and characterized in the venom of the spider ",
    "authors": [
        {
            "affiliation": "The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.",
            "firstname": "Pengpeng",
            "initials": "P",
            "lastname": "Li"
        },
        {
            "affiliation": "The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.",
            "firstname": "Zhongzhe",
            "initials": "Z",
            "lastname": "Zhang"
        },
        {
            "affiliation": "The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.",
            "firstname": "Qiong",
            "initials": "Q",
            "lastname": "Liao"
        },
        {
            "affiliation": "School of Life Sciences, Hunan University of Science and Technology, Xiangtan, China.",
            "firstname": "Er",
            "initials": "E",
            "lastname": "Meng"
        },
        {
            "affiliation": "Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China.",
            "firstname": "James",
            "initials": "J",
            "lastname": "Mwangi"
        },
        {
            "affiliation": "Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China.",
            "firstname": "Ren",
            "initials": "R",
            "lastname": "Lai"
        },
        {
            "affiliation": "The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.",
            "firstname": "Mingqiang",
            "initials": "M",
            "lastname": "Rong"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2020 Li, Zhang, Liao, Meng, Mwangi, Lai and Rong.",
    "doi": "10.3389/fphar.2020.00896\n10.1016/j.bbalip.2010.11.005\n10.1111/j.1365-2141.2009.07605.x\n10.1016/j.bbrc.2004.11.171\n10.1161/ATVBAHA.107.155952\n10.1093/ajcp/65.3.390\n10.1007/s00726-017-2425-2\n10.1016/j.foodchem.2009.04.077\n10.1016/j.bbamem.2012.07.016\n10.1097/MBC.0000000000000336\n10.1182/blood-2011-03-339572\n10.1016/j.annfar.2008.02.009\n10.1016/j.toxicon.2004.02.005\n10.1586/14789450.5.5.731\n10.1016/S1875-5364(16)30071-1\n10.1038/202498a0\n10.1002/pmic.200401096\n10.3390/toxins9010007\n10.1155/2019/4091278\n10.1016/j.toxicon.2011.01.006\n10.1016/s0014-5793(00)01803-2\n10.1182/blood-2011-04-347849\n10.1016/s0304-4165(01)00206-9\n10.1191/0960327104ht475oa\n10.1177/0960327110393761\n10.1177/0960327115597983\n10.1093/cvr/cvt276\n10.1111/j.1538-7836.2007.02382.x\n10.1016/s0742-8413(97)00033-9\n10.1016/j.actbio.2009.07.026\n10.1213/ANE.0000000000001485\n10.1074/mcp.M112.018853\n10.1097/01.ta.0000152892.24841.54\n10.1016/j.zool.2009.04.001\n10.1016/j.biochi.2011.10.015",
    "journal": "Frontiers in pharmacology",
    "keywords": [
        "coagulant",
        "coagulation factors",
        "peptide",
        "spider venom",
        "toxin"
    ],
    "methods": null,
    "publication_date": "2020-07-03",
    "pubmed_id": "32612531\n13654273\n21094694\n19236611\n15652496\n30700128\n1258831\n28497266\n22842000\n26407136\n21828145\n18420371\n15066414\n18937563\n27608950\n14167839\n15852345\n28035974\n31015839\n21277886\n10908720\n21673344\n11731090\n15553173\n21247992\n26253591\n24323317\n17229042\n9366037\n19631768\n27749350\n22595790\n15761343\n19875276\n22085638",
    "results": null,
    "title": "LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom of ",
    "xml": "<Element 'PubmedArticle' at 0x78850382f470>"
}