{
    "abstract": "Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells which consist of 2 subsets: granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC). MDSC expand in tumor-bearing hosts and contribute to immunotherapeutic resistance by remarkably blocking effector T-cell activation via different mechanisms. Resveratrol (RSV) is a polyphenol and it has been widely used for its various health benefits. However, the underlying mechanism of its anti-tumor properties remains unclear. In this study, a transplantable mouse model was used to investigate the effects of RSV on MDSC. The results showed that RSV ameliorated tumor development by decreasing G-MDSC accumulation, impairing its suppressive ability on CD8",
    "authors": [
        {
            "affiliation": "The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.\nDepartment of Immunology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Yilin",
            "initials": "Y",
            "lastname": "Zhao"
        },
        {
            "affiliation": "The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.\nDepartment of Immunology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Qi",
            "initials": "Q",
            "lastname": "Shao"
        },
        {
            "affiliation": "The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.\nDepartment of Immunology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Haitao",
            "initials": "H",
            "lastname": "Zhu"
        },
        {
            "affiliation": "Department of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, China.",
            "firstname": "Haiyuan",
            "initials": "H",
            "lastname": "Xu"
        },
        {
            "affiliation": "The Central Laboratory, Changzhou Woman and Children Health Hospital Affiliated to Nanjing Medical University, Changzhou, China.",
            "firstname": "Wei",
            "initials": "W",
            "lastname": "Long"
        },
        {
            "affiliation": "The Central Laboratory, Changzhou Woman and Children Health Hospital Affiliated to Nanjing Medical University, Changzhou, China.",
            "firstname": "Bin",
            "initials": "B",
            "lastname": "Yu"
        },
        {
            "affiliation": "Department of Immunology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Lining",
            "initials": "L",
            "lastname": "Zhou"
        },
        {
            "affiliation": "The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.\nDepartment of Immunology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Huaxi",
            "initials": "H",
            "lastname": "Xu"
        },
        {
            "affiliation": "The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.\nDepartment of Physiology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Yan",
            "initials": "Y",
            "lastname": "Wu"
        },
        {
            "affiliation": "The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.\nDepartment of Immunology, Jiangsu University, Zhenjiang, China.",
            "firstname": "Zhaoliang",
            "initials": "Z",
            "lastname": "Su"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.",
    "doi": "10.1111/cas.13720",
    "journal": "Cancer science",
    "keywords": [
        "HMGB1",
        "macrophage",
        "myeloid-derived suppressor cells",
        "resveratrol",
        "tumor immunotherapy"
    ],
    "methods": null,
    "publication_date": "2018-07-01",
    "pubmed_id": "29959821\n26140242\n25967145\n26216631\n25949922\n28811975\n27541573\n28220123\n22306898\n28661031\n26832917\n24197130\n29213353\n25281824\n25451966\n25445538\n26704305\n28596842\n24895526\n17872969\n26451317\n26109073\n25709155\n23707808\n27987020\n28216632\n27833703\n25466270\n26078490\n25164013\n26810222\n27299510\n26168215\n22815789\n28546500\n27148534\n27145432\n25042796\n21807089\n22646800\n26528286\n26864266\n28492541\n28401258",
    "results": null,
    "title": "Resveratrol ameliorates Lewis lung carcinoma-bearing mice development, decreases granulocytic myeloid-derived suppressor cell accumulation and impairs its suppressive ability.",
    "xml": "<Element 'PubmedArticle' at 0x7885059895d0>"
}