{
    "abstract": "The assessment of liver fibrosis is crucial for managing autoimmune liver diseases such as primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). However, data on the efficacy of noninvasive tests for these diseases are limited. This meta-analysis evaluated the diagnostic accuracy of vibration-controlled transient elastography (VCTE) for staging fibrosis in patients with autoimmune liver disease.\nSearches were conducted in PubMed, Embase, CINAHL, Web of Science, and Cochrane Library databases to assess the diagnostic accuracy of VCTE against histology as the reference standard in adult patients with autoimmune liver disease. The summary area under the curve (sAUC) and diagnostic odds ratio were calculated for significant fibrosis (SF), advanced fibrosis (AF), and cirrhosis, according to liver biopsy.\nFourteen articles were included, comprising 559 PBC patients from six studies, 388 AIH patients from five studies, and 151 PSC patients from three studies. VCTE demonstrated good performance for fibrosis staging in PBC, AIH, and PSC. In PBC, sAUCs of VCTE were 0.87, 0.89, and 0.99 for staging SF, AF, and cirrhosis, respectively. In AIH, the sAUCs were 0.88, 0.88, and 0.92, respectively, while in PSC, they were 0.88, 0.95, and 0.92, respectively. The cutoff values for AF were 7.5-17.9 kPa in PBC, 8.18-12.1 kPa in AIH, and 9.6 kPa in PSC.\nVCTE shows high diagnostic accuracy for staging liver fibrosis in patients with autoimmune liver diseases. This non-invasive method serves as a valuable tool for the evaluation and monitoring of fibrosis in these lifelong diseases.",
    "authors": [
        {
            "affiliation": "Department of Gastroenterology and Hepatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.",
            "firstname": "Jihyun",
            "initials": "J",
            "lastname": "An"
        },
        {
            "affiliation": "Department of Internal Medicine, Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.",
            "firstname": "Young Eun",
            "initials": "YE",
            "lastname": "Chon"
        },
        {
            "affiliation": "Hanyang University College of Medicine, Seoul, Korea.",
            "firstname": "Gunho",
            "initials": "G",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.\nYonsei Liver Center, Severance Hospital, Seoul, Korea.",
            "firstname": "Mi Na",
            "initials": "MN",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.",
            "firstname": "Hee Yeon",
            "initials": "HY",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.",
            "firstname": "Han Ah",
            "initials": "HA",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.",
            "firstname": "Jung Hwan",
            "initials": "JH",
            "lastname": "Yu"
        },
        {
            "affiliation": "Division of Health Technology Assessment Research, National EvidenceBased Healthcare Collaborating Agency (NECA), Seoul, Korea.",
            "firstname": "Miyoung",
            "initials": "M",
            "lastname": "Choi"
        },
        {
            "affiliation": "Department of Gastroenterology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea.",
            "firstname": "Dae Won",
            "initials": "DW",
            "lastname": "Jun"
        },
        {
            "affiliation": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.\nYonsei Liver Center, Severance Hospital, Seoul, Korea.",
            "firstname": "Seung Up",
            "initials": "SU",
            "lastname": "Kim"
        },
        {
            "affiliation": "Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.",
            "firstname": "Ji Won",
            "initials": "JW",
            "lastname": "Han"
        },
        {
            "affiliation": "Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.",
            "firstname": "Young-Joo",
            "initials": "YJ",
            "lastname": "Jin"
        }
    ],
    "conclusions": "VCTE shows high diagnostic accuracy for staging liver fibrosis in patients with autoimmune liver diseases. This non-invasive method serves as a valuable tool for the evaluation and monitoring of fibrosis in these lifelong diseases.",
    "copyrights": null,
    "doi": "10.3350/cmh.2024.0586\n10.1016/j.cgh.2024.06.035",
    "journal": "Clinical and molecular hepatology",
    "keywords": [
        "Autoimmune disease",
        "Liver fibrosis",
        "Noninvasive test",
        "Transient elastography"
    ],
    "methods": null,
    "publication_date": "2024-08-21",
    "pubmed_id": "39165158\n28427765\n37137334\n35738507\n34266966\n37876996\n33141955\n34474162\n31621931\n18752324\n33065308\n30153359\n32467090\n20501453\n12873821\n37088420\n37900994\n22271046\n21783442\n18081731\n28044427\n32976197\n28070199\n29073121\n27238753\n37125250\n27505153\n24389304\n27723798\n28851259\n6847917\n30070375\n34166721\n39019421\n37962077\n29180000\n37895106",
    "results": "Fourteen articles were included, comprising 559 PBC patients from six studies, 388 AIH patients from five studies, and 151 PSC patients from three studies. VCTE demonstrated good performance for fibrosis staging in PBC, AIH, and PSC. In PBC, sAUCs of VCTE were 0.87, 0.89, and 0.99 for staging SF, AF, and cirrhosis, respectively. In AIH, the sAUCs were 0.88, 0.88, and 0.92, respectively, while in PSC, they were 0.88, 0.95, and 0.92, respectively. The cutoff values for AF were 7.5-17.9 kPa in PBC, 8.18-12.1 kPa in AIH, and 9.6 kPa in PSC.",
    "title": "Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788503b44fe0>"
}