{
    "abstract": "Liberal administration of supplemental oxygen (O\nWe hypothesise that (1) short-term exposure to hyperoxia will induce mild pulmonary inflammation and cellular injury and that (2) hyperoxia will accentuate pulmonary inflammation and cellular injury in the setting of inhaled lipopolysaccharide challenge. To test our hypotheses, we will conduct a randomised, double-blind, placebo-controlled study of hyperoxia administered via a high-flow nasal O\nDissemination of the research findings will be achieved in the following ways: (1) Our findings will be presented at national and international meetings with open-access abstracts online and (2) in accordance with the open-access policies proposed by the leading research funding bodies we aim to publish the findings in high quality peer-reviewed open-access journals.\nNCT05414370.",
    "authors": [
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK dlinden02@qub.ac.uk.\nMater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.",
            "firstname": "Dermot",
            "initials": "D",
            "lastname": "Linden"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.",
            "firstname": "Delia",
            "initials": "D",
            "lastname": "Dorrian"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.",
            "firstname": "Shikha",
            "initials": "S",
            "lastname": "Tandel"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "McKelvey"
        },
        {
            "affiliation": "Mater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.",
            "firstname": "Melanie",
            "initials": "M",
            "lastname": "Bailey"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.",
            "firstname": "John",
            "initials": "J",
            "lastname": "Conlon"
        },
        {
            "affiliation": "Mater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.",
            "firstname": "David",
            "initials": "D",
            "lastname": "Moore"
        },
        {
            "affiliation": "Northern Ireland Clinical Research Facility (NICRF), Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK.",
            "firstname": "Sharon",
            "initials": "S",
            "lastname": "Carr"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.",
            "firstname": "Clifford C",
            "initials": "CC",
            "lastname": "Taggart"
        },
        {
            "affiliation": "Northern Ireland Clinical Research Facility (NICRF), Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK.",
            "firstname": "Judy M",
            "initials": "JM",
            "lastname": "Bradley"
        },
        {
            "affiliation": "Mater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.",
            "firstname": "Joseph",
            "initials": "J",
            "lastname": "Kidney"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.",
            "firstname": "Cecilia M",
            "initials": "CM",
            "lastname": "OKane"
        },
        {
            "affiliation": "Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.\nRegional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.",
            "firstname": "Daniel Francis",
            "initials": "DF",
            "lastname": "McAuley"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.",
    "doi": "10.1136/bmjresp-2024-002393\n10.1186/cc7151\n10.1136/thoraxjnl-2011-200078\n10.1097/00000542-198311000-00012\n10.1007/s00134-006-0382-4\n10.1152/ajplegacy.1947.149.2.277\n10.1152/jappl.1978.45.5.699\n10.1152/ajplung.00010.2008\n10.4187/respcare.01963\n10.3357/AMHP.5393.2019\n10.1111/j.1537-2995.2012.03774.x\n10.1097/CCM.0000000000000998\n10.1165/ajrcmb.19.4.3173\n10.1172/JCI1337\n10.1165/rcmb.2012-0085OC\n10.1165/rcmb.2011-0074OC\n10.1152/ajplung.00308.2009\n10.1126/scitranslmed.aau9959\n10.1001/jama.2010.707\n10.1097/CCM.0b013e3182a27732\n10.1136/jnnp-2013-305505\n10.1001/jama.2016.11993\n10.1056/NEJMoa1903297\n10.1164/rccm.202303-0560OC\n10.1007/s00134-019-05857-x\n10.1001/jama.2021.13011\n10.1056/NEJMoa2208415\n10.1056/NEJMoa2032510\n10.1056/NEJMra1208943\n10.1001/archsurg.1984.01390140057010\n10.1016/j.jhin.2016.03.015\n10.1097/CCM.0000000000005337\n10.1016/S2213-2600(17)30046-2\n10.1186/s12890-021-01648-7\n10.1378/chest.88.6.900\n10.1056/NEJM197012312832702\n10.1097/CCM.0b013e31826a44f6\n10.1136/thoraxjnl-2013-203618\n10.1164/rccm.200810-1584OC\n10.1164/rccm.201310-1892OC\n10.1136/thoraxjnl-2017-210305\n10.1136/thoraxjnl-2016-208571",
    "journal": "BMJ open respiratory research",
    "keywords": [
        "ARDS",
        "Inflammation",
        "Innate Immunity",
        "Oxidative Stress"
    ],
    "methods": null,
    "publication_date": "2025-02-13",
    "pubmed_id": "39939102\n19291278\n21502096\n6638551\n17019545\n4455844\n20239955\n730565\n18621912\n23271823\n31748001\n7287745\n22804568\n25855899\n9761753\n9576762\n22493012\n22227562\n20034961\n32801143\n20516417\n24164953\n23794718\n27706466\n31613432\n37552556\n31748836\n34463696\n36278971\n33471452\n24171518\n6365032\n27112047\n34605781\n28219612\n34496830\n3905287\n4921729\n23263574\n23860341\n19324974\n24716610\n29382797\n28082531",
    "results": null,
    "title": "Effects of ",
    "xml": "<Element 'PubmedArticle' at 0x788504bfa070>"
}