{
    "abstract": "Early graft failure can affect the short- and long-term outcomes of patients undergoing coronary bypass grafting surgery (CABG). The aim of our study was to explore the predictive value of transit-time flow measurement (TTFM) parameters for early graft failure (before discharge) after CABG in different coronary territories and calculate the TTFM cut-off values.\nWe analyzed a total of 761 grafts (360 patients) that were evaluated by intraoperative TTFM and computed tomography angiography prior to discharge. Logistic model was established to detect the parameters of TTFM to predict early graft failure and receiver operating characteristic curve analysis was used to calculate the cut-off values.\nThe overall early graft failure was 3.5%. The results demonstrated that compared with off-pump CABG, mean graft flow volume was higher (28.0 vs 21.0\u2009mL/min, p\u2009=\u20090.000), but pulse index (PI) (2.3 vs 2.5, p\u2009=\u20090.049) and diastolic flow fraction (DF) (68.0% vs 71.0%, p\u2009=\u20090.001) were lower in on-pump CABGs. DF (73.0% vs 65.5%, p\u2009=\u20090.000) of arterial grafts was higher than that of venous grafts. DF (72.0% vs 62.0%, p\u2009=\u20090.000) in left was higher than that in the right coronary artery territories. The results of multivariate logistic analysis showed that not only in the overall (OR 1.18, 95% CI 1.07-1.30, p\u2009=\u20090.001), but also the left (OR 1.21, 95% CI 1.03-1.41, p\u2009=\u20090.017) and right (OR 1.15, 95% CI 1.03-1.29, p\u2009=\u20090.017) coronary artery target territories, PI was a risk factor for early graft failure and the cut-off value was 3.4, 3.4, and 3.6, respectively. For grafts in left target territories, the results showed that DF (OR 0.94, 95% CI 0.91-0.97, p\u2009=\u20090.000) just in the univariate analysis was a risk factor that affected graft failure.\nThe overall early graft failure was about 3.5%. High PI value is a risk factor for early graft failure in not only overall grafts but in grafts of different target territories. DF might be more useful for the quality evaluation of grafts in left than in right target territories.",
    "authors": [
        {
            "affiliation": "Cardiac Surgery Department, Peking University People's Hospital, Beijing, China.",
            "firstname": "Guodong",
            "initials": "G",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Cardiac Surgery Department, Peking University People's Hospital, Beijing, China.",
            "firstname": "Zhou",
            "initials": "Z",
            "lastname": "Zhao"
        },
        {
            "affiliation": "Cardiac Surgery Department, Peking University People's Hospital, Beijing, China.",
            "firstname": "Zengqiang",
            "initials": "Z",
            "lastname": "Han"
        },
        {
            "affiliation": "Cardiac Surgery Department, Peking University People's Hospital, Beijing, China.",
            "firstname": "Qing",
            "initials": "Q",
            "lastname": "Gao"
        },
        {
            "affiliation": "Cardiac Surgery Department, Peking University People's Hospital, Beijing, China.",
            "firstname": "Jing",
            "initials": "J",
            "lastname": "Liu"
        },
        {
            "affiliation": "Cardiac Surgery Department, Peking University People's Hospital, Beijing, China. Electronic address: chenyudoctor@163.com.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Chen"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2020. Published by Elsevier Ltd.",
    "doi": "10.1016/j.jjcc.2020.09.003",
    "journal": "Journal of cardiology",
    "keywords": [
        "Computed tomography angiography",
        "Coronary artery bypass grafting",
        "Early graft failure",
        "Transit-time flow measurement"
    ],
    "methods": null,
    "publication_date": "2020-10-06",
    "pubmed_id": "33012590",
    "results": "The overall early graft failure was 3.5%. The results demonstrated that compared with off-pump CABG, mean graft flow volume was higher (28.0 vs 21.0\u2009mL/min, p\u2009=\u20090.000), but pulse index (PI) (2.3 vs 2.5, p\u2009=\u20090.049) and diastolic flow fraction (DF) (68.0% vs 71.0%, p\u2009=\u20090.001) were lower in on-pump CABGs. DF (73.0% vs 65.5%, p\u2009=\u20090.000) of arterial grafts was higher than that of venous grafts. DF (72.0% vs 62.0%, p\u2009=\u20090.000) in left was higher than that in the right coronary artery territories. The results of multivariate logistic analysis showed that not only in the overall (OR 1.18, 95% CI 1.07-1.30, p\u2009=\u20090.001), but also the left (OR 1.21, 95% CI 1.03-1.41, p\u2009=\u20090.017) and right (OR 1.15, 95% CI 1.03-1.29, p\u2009=\u20090.017) coronary artery target territories, PI was a risk factor for early graft failure and the cut-off value was 3.4, 3.4, and 3.6, respectively. For grafts in left target territories, the results showed that DF (OR 0.94, 95% CI 0.91-0.97, p\u2009=\u20090.000) just in the univariate analysis was a risk factor that affected graft failure.",
    "title": "The predictive value of intraoperative transit-time flow measurement parameters for early graft failure in different target territories.",
    "xml": "<Element 'PubmedArticle' at 0x788506ef9940>"
}