{
    "abstract": "Dried Blood Spots (DBS) revolutionize therapeutic drug monitoring using LC-MS for the precise quantification of cardiovascular drugs (CDs), enabling personalized treatment adapted to patient-specific pharmacokinetics with minimal invasiveness. This study aims to achieve simultaneous quantification of eight CDs in DBS, overcoming physicochemical challenges. A two-step protein precipitation method was used for simple and precise sample preparation. The drugs were analyzed using LC-MS/MS in ESI positive-ion mode, showing high sensitivity and linearity, with a correlation coefficient (r",
    "authors": [
        {
            "affiliation": "Organic Metrology Group, Division of Chemical and Material Metrology, Korea Research Institute of Standards and Science, Yuseong-gu, Daejeon 34113, Republic of Korea; Department of Bio-Analytical Science, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea; Department of Nutrition and Food Science, National Research Centre, Dokki, Cairo 12622, Egypt.",
            "firstname": "Mariam M",
            "initials": "MM",
            "lastname": "Abady"
        },
        {
            "affiliation": "Organic Metrology Group, Division of Chemical and Material Metrology, Korea Research Institute of Standards and Science, Yuseong-gu, Daejeon 34113, Republic of Korea; Department of Bio-Analytical Science, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.",
            "firstname": "Ji-Seon",
            "initials": "JS",
            "lastname": "Jeong"
        },
        {
            "affiliation": "Organic Metrology Group, Division of Chemical and Material Metrology, Korea Research Institute of Standards and Science, Yuseong-gu, Daejeon 34113, Republic of Korea. Electronic address: hajeong.kwon@kriss.re.kr.",
            "firstname": "Ha-Jeong",
            "initials": "HJ",
            "lastname": "Kwon"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 The Authors. Published by Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jchromb.2024.124215",
    "journal": "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences",
    "keywords": [
        "Cardiovascular drugs",
        "Dried blood spots",
        "LC-MS/MS",
        "Method validation",
        "Therapeutic drug monitoring"
    ],
    "methods": null,
    "publication_date": "2024-06-26",
    "pubmed_id": "38917652",
    "results": null,
    "title": "Dried blood spot sampling coupled with liquid chromatography-tandem mass for simultaneous quantitative analysis of multiple cardiovascular drugs.",
    "xml": "<Element 'PubmedArticle' at 0x788502ee2480>"
}