{
    "abstract": "To assess the association between clinical chorioamnionitis and neurodevelopmental disorders at 5\u00a0years of age in children born preterm.\nEPIPAGE 2 is a national, population-based cohort study of children born before 35\u00a0weeks of gestation in France in 2011. We included infants born alive between 24\nAmong 2927 children alive at 5\u00a0years of age, 124 (3%) were born in a context of clinical chorioamnionitis. Overall, 8.2% and 9.6% of children exposed and unexposed, respectively, to clinical chorioamnionitis had moderate-to-severe neurodevelopmental disorders. After multiple imputations and multivariable analysis, clinical chorioamnionitis was not associated with the occurrence of moderate-to-severe neurodevelopmental disorders (aOR,\u00a00.9; 95% CI, 0.5-1.8).\nWe did not find any association between clinical chorioamnionitis and neurodevelopmental disorders at 5\u00a0years of age in children born at <35\u00a0weeks of gestation after preterm labor or preterm premature rupture of membrane.",
    "authors": [
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France; Department of Gynecology and Obstetrics, Robert Debr\u00e9 Hospital, AP-HP, Universit\u00e9 Paris-Cit\u00e9, Paris, France. Electronic address: fanny.salmon@aphp.fr.",
            "firstname": "Fanny",
            "initials": "F",
            "lastname": "Salmon"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France; Department of Gynecology and Obstetrics, Armand Trousseau Hospital, APHP, Paris Sorbonne University, Paris, France.",
            "firstname": "Gilles",
            "initials": "G",
            "lastname": "Kayem"
        },
        {
            "affiliation": "Institute of Primary Health Care (BIHAM), University of Bern, Brisbane, Australia.",
            "firstname": "Emeline",
            "initials": "E",
            "lastname": "Maisonneuve"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France; Department of Neonatal Pediatrics, Armand Trousseau Hospital, APHP, Paris Sorbonne University, Paris, France.",
            "firstname": "Laurence",
            "initials": "L",
            "lastname": "Foix-L'H\u00e9lias"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France.",
            "firstname": "Val\u00e9rie",
            "initials": "V",
            "lastname": "Benhammou"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France.",
            "firstname": "Monique",
            "initials": "M",
            "lastname": "Kaminski"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France.",
            "firstname": "Laetitia",
            "initials": "L",
            "lastname": "Marchand-Martin"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France.",
            "firstname": "Gildas",
            "initials": "G",
            "lastname": "Kana"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, CHU Lille, EA 2694 METRICS, University of Lille, Lille, France.",
            "firstname": "Damien",
            "initials": "D",
            "lastname": "Subtil"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France; Department of Primary Care Medicine, Unit of Population Epidemiology, Geneva University Hospitals, Geneva, Switzerland.",
            "firstname": "Elsa",
            "initials": "E",
            "lastname": "Lorthe"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France; Center for Clinical Investigation P1419, APHP, APHP. Centre- Universit\u00e9 Paris Cit\u00e9, Paris, France.",
            "firstname": "Pierre-Yves",
            "initials": "PY",
            "lastname": "Ancel"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, Paris, France; Department of Neonatal Pediatrics, Poissy Saint Germain Hospital, Clamart, France.",
            "firstname": "Mathilde",
            "initials": "M",
            "lastname": "Letouzey"
        },
        {
            "affiliation": null,
            "firstname": null,
            "initials": null,
            "lastname": null
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 The Author(s). Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.jpeds.2024.113921",
    "journal": "The Journal of pediatrics",
    "keywords": [
        "clinical chorioamnionitis",
        "neurodevelopmental disorders",
        "preterm birth"
    ],
    "methods": null,
    "publication_date": "2024-01-20",
    "pubmed_id": "38242316",
    "results": "Among 2927 children alive at 5\u00a0years of age, 124 (3%) were born in a context of clinical chorioamnionitis. Overall, 8.2% and 9.6% of children exposed and unexposed, respectively, to clinical chorioamnionitis had moderate-to-severe neurodevelopmental disorders. After multiple imputations and multivariable analysis, clinical chorioamnionitis was not associated with the occurrence of moderate-to-severe neurodevelopmental disorders (aOR,\u00a00.9; 95% CI, 0.5-1.8).",
    "title": "Clinical Chorioamnionitis and Neurodevelopment at 5\u00a0Years of Age in Children Born Preterm: The EPIPAGE-2 Cohort Study.",
    "xml": "<Element 'PubmedArticle' at 0x788502a39350>"
}