{
    "abstract": "Detection of deviant stimuli is crucial to orient and adapt our behavior. Previous work shows that deviant stimuli elicit phasic activation of the locus coeruleus (LC), which releases noradrenaline and controls central arousal. However, it is unclear whether the detection of behaviorally relevant deviant stimuli selectively triggers LC responses or other neuromodulatory systems (dopamine, serotonin, and acetylcholine). We combine human functional MRI (fMRI) recordings optimized for brainstem imaging with pupillometry to perform a mapping of deviant-related responses in subcortical structures. Participants have to detect deviant items in a \"local-global\" paradigm that distinguishes between deviance based on the stimulus probability and the sequence structure. fMRI responses to deviant stimuli are distributed in many cortical areas. Both types of deviance elicit responses in the pupil, LC, and other neuromodulatory systems. Our results reveal that the detection of task-relevant deviant items recruits the same multiple subcortical systems across computationally different types of deviance.",
    "authors": [
        {
            "affiliation": "Cognitive Neuroimaging Unit, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Commissariat \u00e0 l'Energie Atomique et aux \u00e9nergies alternatives, Centre national de la recherche scientifique, Universit\u00e9 Paris-Saclay, NeuroSpin center, 91191 Gif/Yvette, France. Electronic address: audrey.mazancieux@gmail.com.",
            "firstname": "Audrey",
            "initials": "A",
            "lastname": "Mazancieux"
        },
        {
            "affiliation": "NeuroSpin, CEA, CNRS, BAOBAB, Universit\u00e9 Paris-Saclay, Gif-Sur-Yvette, France.",
            "firstname": "Franck",
            "initials": "F",
            "lastname": "Mauconduit"
        },
        {
            "affiliation": "NeuroSpin, CEA, CNRS, BAOBAB, Universit\u00e9 Paris-Saclay, Gif-Sur-Yvette, France.",
            "firstname": "Alexis",
            "initials": "A",
            "lastname": "Amadon"
        },
        {
            "affiliation": "Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.",
            "firstname": "Jan",
            "initials": "J",
            "lastname": "Willem de Gee"
        },
        {
            "affiliation": "Section Computational Cognitive Neuroscience, Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.",
            "firstname": "Tobias H",
            "initials": "TH",
            "lastname": "Donner"
        },
        {
            "affiliation": "Cognitive Neuroimaging Unit, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Commissariat \u00e0 l'Energie Atomique et aux \u00e9nergies alternatives, Centre national de la recherche scientifique, Universit\u00e9 Paris-Saclay, NeuroSpin center, 91191 Gif/Yvette, France; Institut de neuromodulation, GHU Paris, psychiatrie et neurosciences, centre hospitalier Sainte-Anne, p\u00f4le hospitalo-universitaire 15, Universit\u00e9 Paris Cit\u00e9, Paris, France. Electronic address: florent.meyniel@cea.fr.",
            "firstname": "Florent",
            "initials": "F",
            "lastname": "Meyniel"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.celrep.2023.113405\n10.1007/978-1-4615-1079-6_16\n10.1101/2021.10.04.463064",
    "journal": "Cell reports",
    "keywords": [
        "CP: Neuroscience",
        "brainstem",
        "deviance detection",
        "locus coeruleus"
    ],
    "methods": null,
    "publication_date": "2023-11-11",
    "pubmed_id": "37950868\n31147631\n2167690\n26582980\n23040811\n8027789\n7488725\n7859103\n32943779\n7859118\n9276487\n6771765\n7843306\n28271441\n24510607\n15722203\n25976634\n32410975\n27512527\n22969714\n12040078\n26352794\n16880131\n28511977\n21389268\n16929307\n15541509\n30232259\n34529938\n17567916\n16060800\n30410536\n20498349\n21762458\n20557480\n21994487\n35107419\n32331857\n28383284\n27824036\n33186549\n25995472\n29107830\n23335883\n19403816\n20395497\n19164526\n26447569\n28782642\n23859924\n25737555\n30287943\n20547229\n25791783\n19524044\n24969472\n22147913\n27247381\n30482692\n22233726\n20664082\n25556836\n6466989\n7753394\n22230230\n24453305\n35174784\n16022602\n33393461\n27191166\n26748086\n9176952\n25086330\n24109446\n18585468\n22592840\n24431986",
    "results": null,
    "title": "Brainstem fMRI signaling of surprise across different types of deviant stimuli.",
    "xml": "<Element 'PubmedArticle' at 0x78850327acf0>"
}