{
    "abstract": "Historically, patients on extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome have received ventilatory \"lung rest\" with conventional or high-frequency oscillating ventilators. We present a series of adults treated with high-frequency percussive ventilation (HFPV) to enhance recovery and recruitment during ECMO. Adult respiratory patients, treated between January 2009 and December 2012 were cared for with a combination of standard ECMO practices and a protocol of recruitment strategies, including HFPV. Data are reported as mean \u00b1 standard error of the mean, percentage, or median. Comparisons are made by \u03c7 for categorical variables and by t-test and Mann-Whitney test for continuous variables. Significance is noted at the 95% confidence level (p < 0.05). There were 39 HFPV patients. They were 39.9 \u00b1 2.2 years of age and had 3.0 \u00b1 0.37 days of mechanical ventilation before the initiation of ECMO. Their pre-ECMO PaO2 to FiO2 ratio (PF ratio) was 52.3 \u00b1 3.0 and their pCO2 was 50.22 \u00b1 2.4. HFPV patients required a mean of 143.1 \u00b1 17.6 hours and a median of 106 hours (range 45.75-350.25) of ECMO support and had a 62% survival to discharge. The post-ECMO PF ratio in the HFPV cohort was 301.8 \u00b1 16.7. A protocolized practice of active recruitment that includes HFPV is associated with reduced duration of ECMO support in adults with respiratory failure.",
    "authors": [
        {
            "affiliation": "From the Legacy Emanuel Medical Center and Pacific Integration, Portland Oregon, University of Michigan Medical Center, Ann Arbor, Michigan.",
            "firstname": "Andrew J",
            "initials": "AJ",
            "lastname": "Michaels"
        },
        {
            "affiliation": null,
            "firstname": "Jon G",
            "initials": "JG",
            "lastname": "Hill"
        },
        {
            "affiliation": null,
            "firstname": "Bernie P",
            "initials": "BP",
            "lastname": "Sperley"
        },
        {
            "affiliation": null,
            "firstname": "Brian P",
            "initials": "BP",
            "lastname": "Young"
        },
        {
            "affiliation": null,
            "firstname": "Tawyna L",
            "initials": "TL",
            "lastname": "Ogston"
        },
        {
            "affiliation": null,
            "firstname": "Connor L",
            "initials": "CL",
            "lastname": "Wiles"
        },
        {
            "affiliation": null,
            "firstname": "Peter",
            "initials": "P",
            "lastname": "Rycus"
        },
        {
            "affiliation": null,
            "firstname": "Tanya R",
            "initials": "TR",
            "lastname": "Shanks"
        },
        {
            "affiliation": null,
            "firstname": "William B",
            "initials": "WB",
            "lastname": "Long"
        },
        {
            "affiliation": null,
            "firstname": "Lori J",
            "initials": "LJ",
            "lastname": "Morgan"
        },
        {
            "affiliation": null,
            "firstname": "Robert H",
            "initials": "RH",
            "lastname": "Bartlett"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1097/MAT.0000000000000196",
    "journal": "ASAIO journal (American Society for Artificial Internal Organs : 1992)",
    "keywords": [],
    "methods": null,
    "publication_date": "2015-01-31",
    "pubmed_id": "25635932",
    "results": null,
    "title": "Use of HFPV for adults with ARDS: the protocolized use of high-frequency percussive ventilation for adults with acute respiratory failure treated with extracorporeal membrane oxygenation.",
    "xml": "<Element 'PubmedArticle' at 0x78850378ab10>"
}