{
    "abstract": "Sickle cell disease (SCD) is associated with complications during pregnancy and can negatively influence maternal outcomes. Our study aimed to determine the prevalence and predictors of maternal morbidity among participants enrolled in an eight-site SCD Implementation Consortium (SCDIC) registry.\nWe conducted a cross-sectional analysis of female registry participants, aged 15-45\u2009years, with a confirmed diagnosis of SCD. Participants completed a survey of self-reported pregnancies and outcomes.\nSeven hundred and thirty-eight individuals had at least one pregnancy event, with 1076 live births. Twenty percent reported a pregnancy loss or fetal demise. Of the 1076 live births, 75% involved at least one complication. The most prevalent complications were pain crises (61.1%) and pregnancy requiring blood transfusion(s) (33.0%). Multiparous individuals with a prior occurrence of a complication in a previous pregnancy had higher odds of recurrence of the same complication in subsequent pregnancies (i.e., previous acute crisis was associated with subsequent acute pain events odds ratio [OR]: 3.13; 95% confidence interval [CI]: 2.06-4.76) and prior transfusion requiring another transfusion (OR: 3.22; 95% CI: 2.01-5.16).\nIndividuals reported a high prevalence of pregnancy loss and maternal complications. Our findings underscore the importance of preconception counseling and early initiation of perinatal care in SCD.",
    "authors": [
        {
            "affiliation": "Division of Women's Community and Population Health, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Joacy G",
            "initials": "JG",
            "lastname": "Mathias"
        },
        {
            "affiliation": "Department of Bioethics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.",
            "firstname": "Rita V",
            "initials": "RV",
            "lastname": "Masese"
        },
        {
            "affiliation": "Washington University School of Medicine, St. Louis, Montana, USA.",
            "firstname": "Allison A",
            "initials": "AA",
            "lastname": "King"
        },
        {
            "affiliation": "University of Tennessee System, College of Nursing, Knoxville, Tennessee, USA.",
            "firstname": "Dominique",
            "initials": "D",
            "lastname": "Bulgin"
        },
        {
            "affiliation": "Duke University School of Nursing, Durham, North Carolina, USA.",
            "firstname": "Eleanor",
            "initials": "E",
            "lastname": "Stevenson"
        },
        {
            "affiliation": "Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.",
            "firstname": "Jane S",
            "initials": "JS",
            "lastname": "Hankins"
        },
        {
            "affiliation": "Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.",
            "firstname": "Jeffrey A",
            "initials": "JA",
            "lastname": "Glassberg"
        },
        {
            "affiliation": "Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama, USA.",
            "firstname": "Julie",
            "initials": "J",
            "lastname": "Kanter"
        },
        {
            "affiliation": "RTI International, Division of Biostatistics and Epidemiology, Research Triangle Park, Durham, North Carolina, USA.",
            "firstname": "Liliana",
            "initials": "L",
            "lastname": "Preiss"
        },
        {
            "affiliation": "Division of Hematology, Department of Pediatrics, University of California San Francisco, Oakland, California, USA.",
            "firstname": "Marsha",
            "initials": "M",
            "lastname": "Treadwell"
        },
        {
            "affiliation": "Duke University School of Nursing, Durham, North Carolina, USA.",
            "firstname": "Mitchell R",
            "initials": "MR",
            "lastname": "Knisely"
        },
        {
            "affiliation": "Duke University School of Nursing, Durham, North Carolina, USA.",
            "firstname": "Paula J",
            "initials": "PJ",
            "lastname": "Tanabe"
        },
        {
            "affiliation": "Department of Emergency Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.",
            "firstname": "Robert",
            "initials": "R",
            "lastname": "Gibson"
        },
        {
            "affiliation": "Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.",
            "firstname": "Victor R",
            "initials": "VR",
            "lastname": "Gordeuk"
        },
        {
            "affiliation": "Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.",
            "firstname": "Nirmish R",
            "initials": "NR",
            "lastname": "Shah"
        }
    ],
    "conclusions": "Individuals reported a high prevalence of pregnancy loss and maternal complications. Our findings underscore the importance of preconception counseling and early initiation of perinatal care in SCD.",
    "copyrights": "\u00a9 2024 International Federation of Gynecology and Obstetrics.",
    "doi": "10.1002/ijgo.15974\n10.1016/j.amepre.2009.12.022\n10.1002/ajh.21475\n10.1182/blood-2014-11-607317\n10.5830/CVJA-2016-021\n10.1182/blood.2023020728\n10.1001/jamanetworkopen.2022.54552\n10.1002/ajh.26495\n10.1002/ajh.25282\n10.1186/s13023-020-01457-x\n10.1007/s10903-020-01102-6\n10.1515/jpm-2013-0275\n10.1111/bjh.17658\n10.1002/phar.2793\n10.1182/blood-2015-06-649319\n10.1002/ajh.26818\n10.1002/ajh.24790\n10.1002/ajh.25356\n10.1016/s0140-6736(17)30193-9\n10.2450/2010.0029-10\n10.1182/bloodadvances.2019001142\n10.1177/2333392820941348\n10.1093/humrep/14.11.2863\n10.1016/j.ajog.2023.10.031\n10.1080/10245332.2017.1367534\n10.1080/01443610500443428\n10.1016/j.fertnstert.2012.06.048\n10.1186/s12884-021-03682-z\n10.1093/aje/kws393\n10.1016/S0140-6736(21)00682-6\n10.1111/bjh.13270",
    "journal": "International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics",
    "keywords": [
        "fertility",
        "pregnancy",
        "pregnant women",
        "sickle cell"
    ],
    "methods": null,
    "publication_date": "2024-10-25",
    "pubmed_id": "39450678\n20331952\n19610078\n25800049\n27213856\n37979134\n36729452\n35142007\n30203558\n32635939\n33034793\n24344096\n34231198\n36928875\n26302758\n36594168\n28512745\n30456766\n28159390\n21251455\n32298430\n32844103\n10548637\n37866731\n28846064\n16483970\n22835448\n33673832\n23558353\n33915094\n25522142",
    "results": "Seven hundred and thirty-eight individuals had at least one pregnancy event, with 1076 live births. Twenty percent reported a pregnancy loss or fetal demise. Of the 1076 live births, 75% involved at least one complication. The most prevalent complications were pain crises (61.1%) and pregnancy requiring blood transfusion(s) (33.0%). Multiparous individuals with a prior occurrence of a complication in a previous pregnancy had higher odds of recurrence of the same complication in subsequent pregnancies (i.e., previous acute crisis was associated with subsequent acute pain events odds ratio [OR]: 3.13; 95% confidence interval [CI]: 2.06-4.76) and prior transfusion requiring another transfusion (OR: 3.22; 95% CI: 2.01-5.16).",
    "title": "Patient-reported pregnancy loss and maternal complications: Insights from the sickle cell disease implementation consortium.",
    "xml": "<Element 'PubmedArticle' at 0x788503c86fc0>"
}