{
    "abstract": "Microneedles have emerged as an effective strategy to bypass the stratum corneum by creating microchannels in the skin, allowing for enhanced drug permeation with minimal invasiveness. Pectin, a natural polysaccharide, when modified with thiol (-SH) groups, exhibits redox-sensitive behavior, making it responsive to reducing agents such as glutathione and dithiothreitol (DTT). The objective of this study was to investigate the transdermal delivery efficacy of redox-responsive microneedle-containing thiolated pectin. Various molar ratios of thiolated pectin were synthesized through the ring-opening reaction followed by nucleophilic substitution of propylene sulfide with pectin. MN matrices were formulated with thiolated pectin at various molar ratios, hyaluronic acid, collagen, and trehalose. The stiffness and mechanical strength of the microneedles increased with higher thiol-containing pectin molecules. The in\u00a0vitro skin permeation release showed a large amount of FITC release when no thiol group was conjugated to pectin. MN-thio: pectin (20:10) with H",
    "authors": [
        {
            "affiliation": "Department of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea.",
            "firstname": "Wenting",
            "initials": "W",
            "lastname": "Long"
        },
        {
            "affiliation": "Department of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea.",
            "firstname": "Jomon",
            "initials": "J",
            "lastname": "George Joy"
        },
        {
            "affiliation": "Department of Pharmaceutical Science and Engineering, Seowon University, Cheongju, Chungbuk, Republic of Korea.",
            "firstname": "Seung-Jun",
            "initials": "SJ",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea.",
            "firstname": "Jin-Chul",
            "initials": "JC",
            "lastname": "Kim"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 Wiley Periodicals LLC.",
    "doi": "10.1002/jbm.a.37903",
    "journal": "Journal of biomedical materials research. Part A",
    "keywords": [
        "redox\u2010responsive microneedle",
        "skin permeation",
        "thiolated pectin",
        "transdermal delivery"
    ],
    "methods": null,
    "publication_date": "2025-03-29",
    "pubmed_id": "40156176",
    "results": null,
    "title": "Collagen- and Hyaluronic Acid-Based Microneedles With Thiolated Pectin for Redox-Responsive Drug Delivery.",
    "xml": "<Element 'PubmedArticle' at 0x788503d9e6b0>"
}