{
    "abstract": "The purpose of this study is to examine the combination of the mechanical effects of penile therapy with vacuum erection devices (VEDs) plus PDE5i, which improve clinical outcomes after extracorporeal shockwave therapy (ESWT) in men affected by erectile dysfunction (ED) associated with Peyronie's disease (PD).\nA total of 153 medical records of patients affected by PD in stable stage with ED and treated with ESWT were divided into two groups. Group A (GA) included 72 men treated with ESWT, mechanical stretching with VEDs and PDE5\u00ec (Tadalafil 5 mg), and Group B (GB) included 81 men who received only ESWT plus Tadalafil 5 mg with the same protocol of GA. The patients in both groups were assessed at baseline and follow-up for erectile function, painful erections, penile plaque size, and penile curvature. The results were evaluated at baseline and 3, 6, and 12 months after the treatments.\nThree months after the treatment, GA patients had a reduction in penile curvature degree from a mean \u00b1 SD of 33.91 \u00b1 8.34\u00b0 at baseline to a mean \u00b1 SD of 19.46 \u00b1 7.15\u00b0 after 12 months, whereas pain in an erection or during intercourse was resolved completely in 88.9% of the patients. The mean \u00b1 SD IIEF-15 score of patients affected by severe/moderate ED further improved significantly in the GA group (\nThe regular use of a VED plus Tadalafil in patients who had undergone ESWT significantly provided more benefit in patients with PD in terms of penile deformity, pain, and erectile function.",
    "authors": [
        {
            "affiliation": "Department of Urology, University-Hospital of Marche, 60126 Ancona, Italy.",
            "firstname": "Lucio",
            "initials": "L",
            "lastname": "Dell'Atti"
        },
        {
            "affiliation": "Pain Therapy Center, Division of Anesthesia and Intensive Care, University-Hospital of Marche, 60126 Ancona, Italy.",
            "firstname": "Viktoria",
            "initials": "V",
            "lastname": "Slyusar"
        },
        {
            "affiliation": "Department of Urology, University-Hospital of Marche, 60126 Ancona, Italy.",
            "firstname": "Piero",
            "initials": "P",
            "lastname": "Ronchi"
        },
        {
            "affiliation": "Department of Emergency, University-Hospital Gemelli IRCSS, 00168 Roma, Italy.",
            "firstname": "Chiara",
            "initials": "C",
            "lastname": "Cambise"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/life14091162\n10.1016/j.sxmr.2019.06.004\n10.1111/iju.14230\n10.1016/j.ucl.2021.07.013\n10.1002/14651858.CD012206.pub2\n10.4103/aja.aja_50_19;\n10.3390/clinpract13050112\n10.21037/tau.2016.11.01\n10.4103/0974-7796.152048\n10.1111/j.1464-410X.2007.07223.x\n10.1111/andr.13224\n10.1007/s40618-023-02015-5\n10.1007/s00345-023-04533-6\n10.1097/01.ju.0000108060.30363.8d\n10.1111/jsm.12275\n10.4103/0974-7796.192100\n10.1016/j.juro.2011.12.117\n10.1111/j.1743-6109.2011.02498.x\n10.1016/j.eururo.2009.05.012\n10.1111/j.1464-410X.2010.09365.x\n10.2147/RRU.S325929\n10.3390/jpm13040679\n10.1016/S1569-9056(17)30442-6\n10.1007/s00120-009-2089-y\n10.1111/j.1365-2605.2011.01226.x\n10.1007/s00345-024-04792-x",
    "journal": "Life (Basel, Switzerland)",
    "keywords": [
        "Peyronie\u2019s disease",
        "erectile dysfunction",
        "extracorporeal shockwave",
        "phosphodiesterase type 5 inhibitors",
        "vacuum erection device"
    ],
    "methods": null,
    "publication_date": "2024-09-28",
    "pubmed_id": "39337945\n31540807\n32253786\n34776050\n37490423\n31169141\n37887088\n28217450\n26229323\n17888043\n35771713\n36698034\n37490060\n14713800\n23898925\n28057983\n22425129\n22008059\n19473751\n20438558\n34557454\n37109065\n19756466\n22085227\n38453751",
    "results": "Three months after the treatment, GA patients had a reduction in penile curvature degree from a mean \u00b1 SD of 33.91 \u00b1 8.34\u00b0 at baseline to a mean \u00b1 SD of 19.46 \u00b1 7.15\u00b0 after 12 months, whereas pain in an erection or during intercourse was resolved completely in 88.9% of the patients. The mean \u00b1 SD IIEF-15 score of patients affected by severe/moderate ED further improved significantly in the GA group (",
    "title": "Vacuum Erection Device Plus Once-Daily Tadalafil Improve Clinical Outcomes after Extracorporeal Shock Wave Therapy in Men Affected by Erectile Dysfunction Associated with Peyronie's Disease.",
    "xml": "<Element 'PubmedArticle' at 0x788504aa4d60>"
}