{
    "abstract": "Antimicrobial lock therapy is recommended for preventing and treating catheter-related bloodstream infections, but different solutions have uncertain efficacy.\nTwo locks, 1.35% taurolidine and 4% ethylenediaminetetraacetic acid (EDTA), were tested on Staphylococcus epidermidis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, multidrug-resistant P. aeruginosa, vancomycin-resistant Enterococcus faecium, Klebsiella oxytoca (carbapenemase producing), K. pneumoniae (extended-spectrum \u03b2-lactamase producing), Candida albicans, and Candida glabrata. Broviac catheter segments were incubated with these organisms and then exposed to various lock solutions. Colony-forming units (CFUs) were counted after 2, 4, and 24\u2009h of incubation.\nTaurolidine showed a significant decrease in CFUs after 2\u2009h in S. aureus, S. epidermidis, methicillin-resistant S. aureus, vancomycin-resistant E. faecium, P. aeruginosa (both sensitive and multidrug-resistant strains), K. oxytoca, C. albicans, and C. glabrata. After 4\u2009h, significant reductions were noted in S. aureus, S. epidermidis, methicillin-resistant S. aureus, P. aeruginosa, multidrug-resistant P. aeruginosa, K. pneumoniae, K. oxytoca, and C. albicans. Taurolidine was also effective after 24\u2009h, especially against methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa. Four percent EDTA acid showed a significant reduction in CFUs after 2\u2009h in S. aureus, vancomycin-resistant E. faecium, P. aeruginosa, K. oxytoca, C. albicans, and C. glabrata. After 4\u2009h, reductions occurred in P. aeruginosa, multidrug-resistant P. aeruginosa, K. oxytoca, and C. albicans and after 24\u2009h in methicillin-resistant S. aureus, P. aeruginosa, and K. oxytoca.\nTaurolidine is more effective than 4% EDTA acid in eradicating Gram-positive and Gram-negative microorganisms and fungi.",
    "authors": [
        {
            "affiliation": "3rd Department of Internal Medicine-Metabolic Care and Gerontology, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.",
            "firstname": "Jakub",
            "initials": "J",
            "lastname": "Visek"
        },
        {
            "affiliation": "Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.",
            "firstname": "Lenka",
            "initials": "L",
            "lastname": "Ryskova"
        },
        {
            "affiliation": "Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.",
            "firstname": "Petra",
            "initials": "P",
            "lastname": "Cesakova"
        },
        {
            "affiliation": "Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.",
            "firstname": "Jana",
            "initials": "J",
            "lastname": "Stanclova"
        },
        {
            "affiliation": "Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.",
            "firstname": "Marie",
            "initials": "M",
            "lastname": "Vajrychova"
        },
        {
            "affiliation": "3rd Department of Internal Medicine-Metabolic Care and Gerontology, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.",
            "firstname": "Vladimir",
            "initials": "V",
            "lastname": "Blaha"
        }
    ],
    "conclusions": "Taurolidine is more effective than 4% EDTA acid in eradicating Gram-positive and Gram-negative microorganisms and fungi.",
    "copyrights": "\u00a9 2025 American Society for Parenteral and Enteral Nutrition.",
    "doi": "10.1002/jpen.2725",
    "journal": "JPEN. Journal of parenteral and enteral nutrition",
    "keywords": [
        "antimicrobial lock",
        "catheter\u2010related blood stream infection",
        "ethylenediaminetetraacetic acid",
        "home parenteral nutrition",
        "taurolidine",
        "venous catheter"
    ],
    "methods": null,
    "publication_date": "2025-01-27",
    "pubmed_id": "39865419",
    "results": "Taurolidine showed a significant decrease in CFUs after 2\u2009h in S. aureus, S. epidermidis, methicillin-resistant S. aureus, vancomycin-resistant E. faecium, P. aeruginosa (both sensitive and multidrug-resistant strains), K. oxytoca, C. albicans, and C. glabrata. After 4\u2009h, significant reductions were noted in S. aureus, S. epidermidis, methicillin-resistant S. aureus, P. aeruginosa, multidrug-resistant P. aeruginosa, K. pneumoniae, K. oxytoca, and C. albicans. Taurolidine was also effective after 24\u2009h, especially against methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa. Four percent EDTA acid showed a significant reduction in CFUs after 2\u2009h in S. aureus, vancomycin-resistant E. faecium, P. aeruginosa, K. oxytoca, C. albicans, and C. glabrata. After 4\u2009h, reductions occurred in P. aeruginosa, multidrug-resistant P. aeruginosa, K. oxytoca, and C. albicans and after 24\u2009h in methicillin-resistant S. aureus, P. aeruginosa, and K. oxytoca.",
    "title": "Comparison of taurolidine with 4% ethylenediaminetetraacetic acid on antimicrobial lock effectiveness: An experimental study.",
    "xml": "<Element 'PubmedArticle' at 0x788502db9990>"
}