{
    "abstract": "To explore the association of wearable device-measured moderate-to-vigorous intensity physical activity (MVPA) with cardiovascular disease (CVD) risk in long-term cancer survivors.\nThis retrospective analysis involved a prospective cohort of 6109 cancer survivors without CVD from the UK Biobank accelerometry subsample. The MVPA volume is categorised into four groups based on guideline recommendations (0-75\u2009min/week, 75-150\u2009min/week, 150-300\u2009min/week, \u2265300\u2009min/week). Cox proportional hazard models are used to investigate the association of MVPA with incident CVD.\nOver a median follow-up of 7.88 years, there were 539 incident CVD events (361 incident coronary artery disease (CAD) events, 155 incident heart failure (HF) events, and 109 incident stroke events). Adjusted CVD incidence rates (95% CIs) across MVPA groups (0-75\u2009min/week, 75-150\u2009min/week, 150-300\u2009min/week, \u2265300\u2009min/week) were 15.30 (12.90, 18.10), 13.50 (11.00, 16.40), 12.00 (10.20, 14.10) and 9.86 (8.35, 11.60) per 1000 person-years, respectively. Adjusted HRs (95%\u2009CI) for CVD, CAD, HF and stroke in the highest MVPA group (\u2265300\u2009min/week) compared with those in the lowest MVPA group (0-75\u2009min/week) were 0.63 (0.49, 0.80), 0.68 (0.51, 0.91), 0.66 (0.42,1.06) and 0.72 (0.42, 1.23), respectively. For obesity-related cancers, the beneficial effect on CVD was observed when exceeding 300 MVPA min/week (HR 0.54 (0.37-0.81)) compared with the lowest MVPA group.\nFindings from the UK Biobank study suggest that longer MVPA durations are associated with reduced CVD risk in cancer survivors, underscoring the potential for physical activity to serve as a key component in cardio-oncology care.",
    "authors": [
        {
            "affiliation": "Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.",
            "firstname": "Chengqing",
            "initials": "C",
            "lastname": "Jiang"
        },
        {
            "affiliation": "Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.",
            "firstname": "Ziang",
            "initials": "Z",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Medicine for Sports and Performing Arts, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan.",
            "firstname": "Bo",
            "initials": "B",
            "lastname": "Guo"
        },
        {
            "affiliation": "Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.",
            "firstname": "Lin",
            "initials": "L",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
            "firstname": "Liang",
            "initials": "L",
            "lastname": "Zhu"
        },
        {
            "affiliation": "Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Liang"
        },
        {
            "affiliation": "Institute of computing technology, Chinese Academy of Sciences, Beijing, China.",
            "firstname": "Yinghan",
            "initials": "Y",
            "lastname": "Shen"
        },
        {
            "affiliation": "Cardiac Arrhythmia Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
            "firstname": "Tianxin",
            "initials": "T",
            "lastname": "Long"
        },
        {
            "affiliation": "Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China.",
            "firstname": "Ming",
            "initials": "M",
            "lastname": "Zhai"
        },
        {
            "affiliation": "Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China.",
            "firstname": "Jiayun",
            "initials": "J",
            "lastname": "Shi"
        },
        {
            "affiliation": "Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China yongjianwu_nccd@163.com xuhaiyan@fuwaihospital.org.",
            "firstname": "Haiyan",
            "initials": "H",
            "lastname": "Xu"
        },
        {
            "affiliation": "Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China yongjianwu_nccd@163.com xuhaiyan@fuwaihospital.org.",
            "firstname": "Yongjian",
            "initials": "Y",
            "lastname": "Wu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.",
    "doi": "10.1136/bjsports-2024-108734",
    "journal": "British journal of sports medicine",
    "keywords": [
        "Accelerometer",
        "Exercise",
        "Public health"
    ],
    "methods": null,
    "publication_date": "2025-03-13",
    "pubmed_id": "40074236",
    "results": "Over a median follow-up of 7.88 years, there were 539 incident CVD events (361 incident coronary artery disease (CAD) events, 155 incident heart failure (HF) events, and 109 incident stroke events). Adjusted CVD incidence rates (95% CIs) across MVPA groups (0-75\u2009min/week, 75-150\u2009min/week, 150-300\u2009min/week, \u2265300\u2009min/week) were 15.30 (12.90, 18.10), 13.50 (11.00, 16.40), 12.00 (10.20, 14.10) and 9.86 (8.35, 11.60) per 1000 person-years, respectively. Adjusted HRs (95%\u2009CI) for CVD, CAD, HF and stroke in the highest MVPA group (\u2265300\u2009min/week) compared with those in the lowest MVPA group (0-75\u2009min/week) were 0.63 (0.49, 0.80), 0.68 (0.51, 0.91), 0.66 (0.42,1.06) and 0.72 (0.42, 1.23), respectively. For obesity-related cancers, the beneficial effect on CVD was observed when exceeding 300 MVPA min/week (HR 0.54 (0.37-0.81)) compared with the lowest MVPA group.",
    "title": "Wearable device-measured physical activity and incident cardiovascular disease in cancer survivors.",
    "xml": "<Element 'PubmedArticle' at 0x788503d4b420>"
}