{
    "abstract": "Retroperitoneal liposarcomas (RPLPS) are rare soft tissue sarcomas that often present asymptomatically, leading to delayed diagnosis and challenging management. This case series highlights the impact of histological subtypes on prognosis and recurrence.\nThree male patients with recurrent RPLPS were compared. Two cases of well-differentiated liposarcoma (WDLPS) had favorable outcomes with tumor-free margins, despite recurrence in one. The third case, a dedifferentiated liposarcoma (DDLPS), presented with a larger, high-grade tumor requiring extensive resection and had a higher recurrence risk.\nHistological subtype, tumor size, and grade were key prognostic factors. WDLPS showed better outcomes, while DDLPS was more aggressive despite radical surgery. Recurrence remained a major concern, emphasizing the need for early detection and vigilant long-term surveillance.\nThis case series underscores the variability in RPLPS presentation and outcomes, highlighting the need for individualized surgical strategies and close follow-up to improve long-term prognosis.",
    "authors": [
        {
            "affiliation": "Department of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.",
            "firstname": "Hesameddin",
            "initials": "H",
            "lastname": "Eghlimi"
        },
        {
            "affiliation": "Department of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.",
            "firstname": "Hamidreza",
            "initials": "H",
            "lastname": "Movahedi"
        },
        {
            "affiliation": "School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: pooyanparisa07@gmail.com.",
            "firstname": "Parisa",
            "initials": "P",
            "lastname": "Pooyan"
        }
    ],
    "conclusions": "This case series underscores the variability in RPLPS presentation and outcomes, highlighting the need for individualized surgical strategies and close follow-up to improve long-term prognosis.",
    "copyrights": "Copyright \u00a9 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.",
    "doi": "10.1016/j.ijscr.2025.111284",
    "journal": "International journal of surgery case reports",
    "keywords": [
        "Dedifferentiated liposarcoma",
        "Recurrent liposarcoma",
        "Retroperitoneal liposarcoma",
        "Well-differentiated liposarcoma"
    ],
    "methods": null,
    "publication_date": "2025-04-27",
    "pubmed_id": "40286690",
    "results": null,
    "title": "Variability in recurrent retroperitoneal liposarcomas: A case series exploring histological subtypes.",
    "xml": "<Element 'PubmedArticle' at 0x788503edbfb0>"
}