{
    "abstract": "Cervical cancer is a global health problem due to its high incidence and prevalence in women, mainly in third-world countries. For the treatment of this disease, there are different therapeutic options, but these are not always effective, which gives rise to the search for new compounds using cheminformatics tools.\nThe objective of this study was to design, synthesize, and biologically evaluate N-(2- morpholinoethyl)-2-(naphthalen-2-yloxy)acetamide hydrochloride (1) and 2-(naphthalen-2-yloxy)- N-(2-(piperidin-1-yl)ethyl)acetamide hydrochloride (2) on the HeLa cell line \nTherapies directed at the \u03c31 receptor may be a treatment alternative since this receptor modulates the processes of cell proliferation and angiogenesis, producing cytoprotective or cytotoxic actions depending on the ligand with which it is coupled.\nThe analysis showed that compounds 1 and 2 presented activity on HeLa cancer cells and viability at micromolar concentrations (1.923 \u03bcmol/mL and 0.374 \u03bcmol/mL, respectively). Moreover, the effect was maintained for 72 h.\nNaphthaleneacetamide derivatives exhibited an inhibitory effect on the HeLa cell line, and the OSIRIS program predicted less toxicity than cisplatin.",
    "authors": [
        {
            "affiliation": "Department of Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Ciudad de M\u00e9xico, M\u00e9xico.",
            "firstname": "Cristina",
            "initials": "C",
            "lastname": "Martinez-Nava"
        },
        {
            "affiliation": "Department of Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoac\u00e1n, C.P. 04960, Ciudad de M\u00e9xico, M\u00e9xico.",
            "firstname": "Cuauhtemoc",
            "initials": "C",
            "lastname": "Perez-Gonzalez"
        },
        {
            "affiliation": "Department of Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoac\u00e1n, C.P. 04960, Ciudad de M\u00e9xico, M\u00e9xico.",
            "firstname": "Miguel \u00c1ngel",
            "initials": "M\u00c1",
            "lastname": "Zavala-Sanchez"
        },
        {
            "affiliation": "Department of Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoac\u00e1n, C.P. 04960, Ciudad de M\u00e9xico, M\u00e9xico.",
            "firstname": "Erick Cuauhtemoc",
            "initials": "EC",
            "lastname": "Perez-Montiel"
        },
        {
            "affiliation": "Departamento de Farmacobiolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados Sede Sur, Laboratorio No. 7 'Dolor y Analgesia' Calzado de los Tenorios No. 235, Colonia Granjas Coapa, C.P. 14330, CDMX, Mexico.",
            "firstname": "Francisco Javier",
            "initials": "FJ",
            "lastname": "Lopez-Munoz"
        },
        {
            "affiliation": "Department of Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoac\u00e1n, C.P. 04960, Ciudad de M\u00e9xico, M\u00e9xico.",
            "firstname": "Carlos Alberto",
            "initials": "CA",
            "lastname": "Mendez-Cuesta"
        }
    ],
    "conclusions": "Naphthaleneacetamide derivatives exhibited an inhibitory effect on the HeLa cell line, and the OSIRIS program predicted less toxicity than cisplatin.",
    "copyrights": "Copyright\u00a9 Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.",
    "doi": "10.2174/0115734064321632241022082028",
    "journal": "Medicinal chemistry (Shariqah (United Arab Emirates))",
    "keywords": [
        "AutoDock 4.2.",
        "HeLa cells",
        "Molecular docking",
        "cytotoxicity",
        "naphthaleneacetamide derivatives",
        "novel compounds",
        "sigma-1 receptor"
    ],
    "methods": null,
    "publication_date": "2025-03-12",
    "pubmed_id": "40070144",
    "results": "The analysis showed that compounds 1 and 2 presented activity on HeLa cancer cells and viability at micromolar concentrations (1.923 \u03bcmol/mL and 0.374 \u03bcmol/mL, respectively). Moreover, the effect was maintained for 72 h.",
    "title": "Characterization of the Cytotoxic Effect of Naphthalenacetamides Hydrochlorides on Cervical Cancer-Derived Cells.",
    "xml": "<Element 'PubmedArticle' at 0x78850341b1a0>"
}