{
    "abstract": "Nonobstructive azoospermia (NOA) and primary ovarian insufficiency (POI) have common genetics that may also predispose patients to cancer risk.\nWe hypothesized that NOA or severe oligozoospermia and the risk of male cancers would be higher in families of women with POI.\nWomen with POI were identified using International Classification of Disease codes in electronic medical records (1995-2021) from 2 major healthcare systems in Utah and reviewed for accuracy. Using genealogy information in the Utah Population Database, women with POI (n = 392) and their relatives were included if there were at least 3 generations of ancestors available. Men with NOA or severe oligozoospermia (\u22645 million/mL) from the Subfertility Health and Assisted Reproduction and the Environment Study were identified in these families and risk was calculated in relatives compared to population rates. The relative risk of prostate and testicular cancer was examined using the Utah Cancer Registry.\nThere was an increased risk of NOA/severe oligozoospermia in relatives of women with POI among first- (relative risk 2.8 [95% confidence interval 1.1, 6.7]; \nThe data demonstrate excess familial clustering of severe spermatogenic impairment compared to matched population rates, along with higher prostate cancer risk in relatives of women with POI. These findings support a common genetic contribution to POI, spermatogenic impairment, and prostate cancer.",
    "authors": [
        {
            "affiliation": "Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA.",
            "firstname": "Kristina",
            "initials": "K",
            "lastname": "Allen-Brady"
        },
        {
            "affiliation": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.",
            "firstname": "Samantha",
            "initials": "S",
            "lastname": "Kodama"
        },
        {
            "affiliation": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.\nDepartment of Obstetrics and Gynecology, Intermountain Healthcare, Murray, UT 84107, USA.",
            "firstname": "Lauren E",
            "initials": "LE",
            "lastname": "Verrilli"
        },
        {
            "affiliation": "Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA.",
            "firstname": "Joemy M",
            "initials": "JM",
            "lastname": "Ramsay"
        },
        {
            "affiliation": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.",
            "firstname": "Erica B",
            "initials": "EB",
            "lastname": "Johnstone"
        },
        {
            "affiliation": "Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA.",
            "firstname": "Joshua J",
            "initials": "JJ",
            "lastname": "Horns"
        },
        {
            "affiliation": "Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA.",
            "firstname": "Benjamin R",
            "initials": "BR",
            "lastname": "Emery"
        },
        {
            "affiliation": "Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA.",
            "firstname": "Lisa",
            "initials": "L",
            "lastname": "Cannon-Albright"
        },
        {
            "affiliation": "Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA.",
            "firstname": "Kenneth I",
            "initials": "KI",
            "lastname": "Aston"
        },
        {
            "affiliation": "Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA.",
            "firstname": "James M",
            "initials": "JM",
            "lastname": "Hotaling"
        },
        {
            "affiliation": "Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.",
            "firstname": "Corrine K",
            "initials": "CK",
            "lastname": "Welt"
        }
    ],
    "conclusions": "The data demonstrate excess familial clustering of severe spermatogenic impairment compared to matched population rates, along with higher prostate cancer risk in relatives of women with POI. These findings support a common genetic contribution to POI, spermatogenic impairment, and prostate cancer.",
    "copyrights": "\u00a9 The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society.",
    "doi": "10.1210/jendso/bvaf030",
    "journal": "Journal of the Endocrine Society",
    "keywords": [
        "genetics",
        "heritability",
        "infertility",
        "meiosis",
        "menopause",
        "prostate cancer"
    ],
    "methods": null,
    "publication_date": "2025-03-06",
    "pubmed_id": "40046104\n17970776\n34718612\n36099812\n34095689\n36732629\n36177363\n35285020\n37365320\n36202298\n35587281\n34718620\n33508233\n36283864\n38996041\n23790640\n27336212\n32531249\n29540502\n15640358\n29240891\n24914684\n30948856\n7024719\n31535215\n34794894\n35043201\n32923857\n30207912\n34963702\n30730552\n29659569\n20309846\n25463997\n11415949\n31554611",
    "results": "There was an increased risk of NOA/severe oligozoospermia in relatives of women with POI among first- (relative risk 2.8 [95% confidence interval 1.1, 6.7]; ",
    "title": "Azoospermia/Oligozoospermia and Prostate Cancer Are Increased in Families of Women With Primary Ovarian Insufficiency.",
    "xml": "<Element 'PubmedArticle' at 0x788504b39120>"
}