{
    "abstract": "Anterior segment diseases are among the most common ocular conditions, severely impacting individuals' visual health. Additionally, due to the barrier functions of the anterior segment tissues, traditional treatment methods often suffer from low efficiency and significant side effects, presenting urgent challenges that need to be addressed. Gelatin inherently possesses excellent biocompatibility and biodegradability, and when combined with its unique cell adhesion sequences and the ability to flexibly modulate mechanical and optical properties through physical and chemical modifications, it demonstrates tremendous potential in anterior segment tissue engineering and drug delivery applications. Compared to conventional surgical and eye drop therapies, gelatin-based materials can reduce the risk of complications, enhance drug bioavailability, extend drug retention time, and achieve personalized and precise treatment for various anterior segment diseases through technologies such as 3D bioprinting. However, gelatin-based materials have limitations, including low mechanical strength and thermal stability. Therefore, this paper focuses on recent research regarding the application of gelatin-based materials in anterior segment diseases, systematically summarizing their advantages in treatment, the challenges they face, and their developmental potential.",
    "authors": [
        {
            "affiliation": "Department of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China.",
            "firstname": "Zhijian",
            "initials": "Z",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China; Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian 116033, PR China. Electronic address: ancf001@163.com.",
            "firstname": "Chuanfeng",
            "initials": "C",
            "lastname": "An"
        },
        {
            "affiliation": "Department of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China.",
            "firstname": "Chunxiao",
            "initials": "C",
            "lastname": "Yan"
        },
        {
            "affiliation": "Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China.",
            "firstname": "Lin",
            "initials": "L",
            "lastname": "Jin"
        },
        {
            "affiliation": "Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China.",
            "firstname": "He",
            "initials": "H",
            "lastname": "Dong"
        },
        {
            "affiliation": "Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China.",
            "firstname": "Yuanyuan",
            "initials": "Y",
            "lastname": "Qi"
        },
        {
            "affiliation": "MOE Key Laboratory of Bio-Intelligent Manufacturing, Dalian Key Laboratory of Artificial Organ and Regenerative Medicine, School of Bioengineering, Dalian University of Technology, Liaoning, Dalian 116024, PR China. Electronic address: huananwang@dlut.edu.cn.",
            "firstname": "Huanan",
            "initials": "H",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian 116033, PR China; Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian 116033, PR China. Electronic address: Lijunzhangw1970@163.com.",
            "firstname": "Lijun",
            "initials": "L",
            "lastname": "Zhang"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.ijbiomac.2025.142695",
    "journal": "International journal of biological macromolecules",
    "keywords": [
        "Anterior segment diseases",
        "Gelatin-based materials",
        "Tissue engineering and drug delivery"
    ],
    "methods": null,
    "publication_date": "2025-04-02",
    "pubmed_id": "40169051",
    "results": null,
    "title": "Advances in the application of gelatin-based materials in anterior segment diseases.",
    "xml": "<Element 'PubmedArticle' at 0x788501dede90>"
}