{
    "abstract": "Parenchymal liver metastases from ovarian cancer, occurring in 2-12.5% of cases, significantly worsen prognosis. While surgery and systemic treatments remain primary options, unresectable or chemotherapy-resistant multiple liver metastases pose a significant challenge. Recent advances in liver-directed therapies, including radiofrequency ablation, microwave ablation, cryoablation, transarterial chemoembolization (TACE), and radioembolization, offer potential treatment alternatives. However, the efficacy of these techniques is limited by factors such as tumor size, number, and location. The ideal candidate for tumor ablation is a patient with paucifocal disease, a single tumor up to 5\u00a0cm or up to 3 tumors smaller than 3\u00a0cm and tumors 1\u00a0cm away from major bile ducts and high-flow vessels. Transarterial chemoembolization could be performed in patients with less than 70% tumor load. Differently, radioembolization is available with less limitation on the sites or number of liver cancers. Radioembolization techniques are also able to downsize liver metastases. However, there are limited data regarding the outcomes of loco-regional therapy in patients with hepatic metastases from ovarian cancer. Advancing liver-directed therapies through interventional oncology, combined with robust data on the oncological efficacy of these local treatments, will validate their potential as effective locoregional therapies for liver metastases. This could offer a promising treatment option for patients with ovarian cancer and unresectable hepatic metastases.",
    "authors": [
        {
            "affiliation": "Gynecology Oncology Unit, Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\", Naples, Italy. giuseppecucinella@outlook.com.",
            "firstname": "Giuseppe",
            "initials": "G",
            "lastname": "Cucinella"
        },
        {
            "affiliation": "Gynecology Oncology Unit, Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\", Naples, Italy.",
            "firstname": "Mariano Catello",
            "initials": "MC",
            "lastname": "Di Donna"
        },
        {
            "affiliation": "Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127, Palermo, Italy.",
            "firstname": "Francesca",
            "initials": "F",
            "lastname": "De Maria"
        },
        {
            "affiliation": "Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127, Palermo, Italy.",
            "firstname": "Andrea",
            "initials": "A",
            "lastname": "Etrusco"
        },
        {
            "affiliation": "Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127, Palermo, Italy.",
            "firstname": "Giulia",
            "initials": "G",
            "lastname": "Zaccaria"
        },
        {
            "affiliation": "Ospedale San Leonardo, Castellammare di Stabia, ASL NA3 SUD, Naples, Italy.",
            "firstname": "Natalina",
            "initials": "N",
            "lastname": "Buono"
        },
        {
            "affiliation": "Unit of Gynecologic Oncology, ARNAS \"Civico-Di Cristina-Benfratelli\", University of Palermo, 90127, Palermo, Italy.",
            "firstname": "Antonino",
            "initials": "A",
            "lastname": "Abbate"
        },
        {
            "affiliation": "Clinic of Obstetrics and Gynecology, \"Santa Maria della Misericordia\" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.\nPhD School in Biomedical Sciences, Gender Medicine, Child and Women Health, University of Sassari, Sassari, Sardinia, Italy.",
            "firstname": "Stefano",
            "initials": "S",
            "lastname": "Restaino"
        },
        {
            "affiliation": "Gynecology Oncology Unit, Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\", Naples, Italy.",
            "firstname": "Cono",
            "initials": "C",
            "lastname": "Scaffa"
        },
        {
            "affiliation": "Clinic of Obstetrics and Gynecology, \"Santa Maria della Misericordia\" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.\nDepartment of Medicine (DMED), University of Udine, Udine, Italy.",
            "firstname": "Giuseppe",
            "initials": "G",
            "lastname": "Vizzielli"
        },
        {
            "affiliation": "Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127, Palermo, Italy.\nUnit of Obstetrics and Gynecology, \"Paolo Giaccone\" Hospital, 90127, Palermo, Italy.",
            "firstname": "Antonio Simone",
            "initials": "AS",
            "lastname": "Lagan\u00e0"
        },
        {
            "affiliation": "Gynecology Oncology Unit, Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\", Naples, Italy.",
            "firstname": "Vito",
            "initials": "V",
            "lastname": "Chiantera"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
    "doi": "10.1007/s11864-024-01266-5\n10.3389/fonc.2021.793024\n10.3322/caac.21492\n10.1080/02656736.2019.1706767\n10.1016/j.esxm.2019.07.005\n10.3390/cancers15020500\n10.1097/IGC.0000000000000939\n10.1016/j.ygyno.2011.11.001\n10.1002/1097-0142(19891001)64:7<1508::AID-CNCR2820640725>3.0.CO;2-V\n10.1007/s00330-007-0736-5\n10.21037/hbsn.2018.12.06\n10.1016/j.jvir.2020.11.011\n10.1136/ijgc-00009577-200505001-00002\n10.1007/s12664-016-0657-9\n10.1016/j.jvir.2021.01.270\n10.1155/2018/4756147\n10.1055/s-0039-1696650\n10.1016/j.ejro.2022.100399\n10.1055/s-0038-1636518\n10.1055/s-0041-1732318\n10.1159/000440677\n10.1016/j.jhep.2012.05.007\n10.1097/01.sla.0000201480.65519.b8\n10.1245/aso.2003.03.018\n10.1097/IGC.0000000000000420\n10.1002/14651858.CD009058.pub3\n10.1097/00000658-199702000-00007\n10.1148/radiol.2501080295\n10.21037/jgo.2017.03.13\n10.2967/jnumed.116.186379\n10.1007/s13139-019-00615-9\n10.1097/COC.0b013e3181ec61bb\n10.1148/radiol.2472062029\n10.12659/MSM.890480\n10.1007/s003300050732\n10.1007/s13139-019-00576-z",
    "journal": "Current treatment options in oncology",
    "keywords": [
        "Cryoablation",
        "Interventional oncology",
        "Liver metastases",
        "Ovarian cancer",
        "Radioembolization"
    ],
    "methods": null,
    "publication_date": "2024-10-19",
    "pubmed_id": "39425830\n30207593\n31918591\n31501030\n36672451\n28640176\n22079359\n4085488\n2776109\n17701180\n33636309\n27185180\n33608192\n29974040\n31798209\n34629712\n26889144\n12513961\n28730773\n25793465\n31291464\n9065296\n19092099\n28480062\n30361378\n31867071\n20921882\n18349311\n10354884\n31057678",
    "results": null,
    "title": "Chemoembolization, Radioembolization, and Percutaneous Ablation: New Opportunities for Treating Ovarian Cancer Liver Metastasis.",
    "xml": "<Element 'PubmedArticle' at 0x788503083f60>"
}