{
    "abstract": "OHVIRA syndrome, a urogenital malformation, lacks standardized management. Narrative reviews exist, but there is no a comprehensive meta-analysis.\nThe aim of this first systematic review and meta-analysis is to evaluate the current literature and inform management strategies.\nWe searched Scopus, Medline, Embase and Web of Science, up to March 2024.\nCase series, case reviews, and longitudinal studies on patients with OHVIRA syndrome.\nData were extracted and meta-analyzed using R software.\nIn all, 35 studies (1988-2022) with 526 patients were included. Average symptom onset was 14.45\u2009years, and diagnosis at 16.36\u2009years suggests potential delays. The most common symptoms were abdominal pain (67%, 95% CI 54-77, I\nEarly diagnosis and surgery are crucial to prevent complications. Vaginal septum resection remains the gold standard, while hysteroscopy offers a promising minimally invasive alternative.",
    "authors": [
        {
            "affiliation": "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.",
            "firstname": "Emma",
            "initials": "E",
            "lastname": "Bonetti"
        },
        {
            "affiliation": "Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.\nUniversit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.",
            "firstname": "Gloria",
            "initials": "G",
            "lastname": "Anderson"
        },
        {
            "affiliation": "Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.",
            "firstname": "Simona",
            "initials": "S",
            "lastname": "Duranti"
        },
        {
            "affiliation": "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.",
            "firstname": "Federico",
            "initials": "F",
            "lastname": "Ferrari"
        },
        {
            "affiliation": "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.",
            "firstname": "Franco",
            "initials": "F",
            "lastname": "Odicino"
        },
        {
            "affiliation": "Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.\nDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.",
            "firstname": "Antonia",
            "initials": "A",
            "lastname": "Testa"
        },
        {
            "affiliation": "Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.\nDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.",
            "firstname": "Francesco",
            "initials": "F",
            "lastname": "Fanfani"
        },
        {
            "affiliation": "Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy.\nDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.",
            "firstname": "Giovanni",
            "initials": "G",
            "lastname": "Scambia"
        },
        {
            "affiliation": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.",
            "firstname": "Ursula",
            "initials": "U",
            "lastname": "Catena"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.",
    "doi": "10.1002/ijgo.70164",
    "journal": "International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics",
    "keywords": [
        "Herlyn\u2013Werner\u2013Wunderlich syndrome",
        "OHVIRA syndrome",
        "obstructed hemivagina",
        "vaginal septum resection"
    ],
    "methods": null,
    "publication_date": "2025-04-17",
    "pubmed_id": "40244568",
    "results": null,
    "title": "Clinical features and surgical options of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A systematic review and a meta-analysis of prevalence.",
    "xml": "<Element 'PubmedArticle' at 0x78850692df80>"
}