{
    "abstract": "Bentonite (BT), an orally administrable natural clay, is widely used for medical and pharmaceutical purposes due to its unique properties, including swelling, adsorption and ion-exchange. However, its application as a matrix of amorphous solid dispersion (ASD) formulations is rarely reported, despite the fact that drugs can adsorb to BT in an amorphous state. The objective of this study was to explore the feasibility of BT as a water-insoluble ASD matrix for enhancing the oral bioavailability of poorly water-soluble drugs, including sorafenib (SF). We prepared a novel BT-based ASD of an SF-BT composite (SFBTC) by adsorbing SF onto BT under acidic conditions using the ionic interaction between cationic SF and negatively charged BT. Scanning electron microscopy (SEM), powder X-ray diffractometry (pXRD), and differential scanning calorimetry (DSC) analyses revealed that SF adsorbed to BT in an amorphous state at SF:BT ratios from 1:3 to 1:10. In pharmacokinetic studies in rats, SFBTC (1:3) significantly improved the oral bioavailability of SF, and the AUC",
    "authors": [
        {
            "affiliation": "College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.",
            "firstname": "Min-Jun",
            "initials": "MJ",
            "lastname": "Baek"
        },
        {
            "affiliation": "College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.",
            "firstname": "Ju-Hwan",
            "initials": "JH",
            "lastname": "Park"
        },
        {
            "affiliation": "College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.",
            "firstname": "Duy-Thuc",
            "initials": "DT",
            "lastname": "Nguyen"
        },
        {
            "affiliation": "College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.",
            "firstname": "Dahan",
            "initials": "D",
            "lastname": "Kim"
        },
        {
            "affiliation": "Advanced Geo-materials Research Department, Korea Institute of Geoscience and Mineral Resources, Pohang 37559, Republic of Korea.",
            "firstname": "Jaehwan",
            "initials": "J",
            "lastname": "Kim"
        },
        {
            "affiliation": "Advanced Geo-materials Research Department, Korea Institute of Geoscience and Mineral Resources, Pohang 37559, Republic of Korea.",
            "firstname": "Il-Mo",
            "initials": "IM",
            "lastname": "Kang"
        },
        {
            "affiliation": "College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address: ddkim@snu.ac.kr.",
            "firstname": "Dae-Duk",
            "initials": "DD",
            "lastname": "Kim"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2023 Elsevier B.V. All rights reserved.",
    "doi": "10.1016/j.jconrel.2023.09.051",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "keywords": [
        "Amorphous solid dispersion",
        "Bentonite",
        "Diffusion-controlled release",
        "Oral bioavailability",
        "Sorafenib, poorly water-soluble drug",
        "Supersaturation"
    ],
    "methods": null,
    "publication_date": "2023-10-06",
    "pubmed_id": "37797889",
    "results": null,
    "title": "Bentonite as a water-insoluble amorphous solid dispersion matrix for enhancing oral bioavailability of poorly water-soluble drugs.",
    "xml": "<Element 'PubmedArticle' at 0x7885023fb740>"
}