{
    "abstract": "Estrogen receptor (ER) and human epidermal growth factor 2 (HER2) expression guide the use of neoadjuvant chemotherapy (NACT) in patients with early breast cancer. We evaluate the independent predictive value of adding a multigene profile (CIT256 and PAM50) to immunohistochemical (IHC) profile regarding pathological complete response (pCR) and conversion of positive to negative axillary lymph node status. The cohort includes 458 patients who had genomic profiling performed as standard of care. Using logistic regression, higher pCR and node conversion rates among patients with Non-luminal subtypes are shown, and importantly the predictive value is independent of IHC profile. In patients with ER-positive and HER2-negative breast cancer an odds ratio of 9.78 (95% CI 2.60;36.8), P\u2009<\u20090.001 is found for pCR among CIT256 Non-luminal vs. Luminal subtypes. The results suggest a role for integrated use of up-front multigene subtyping for selection of a neoadjuvant approach in ER-positive HER2-negative breast cancer.",
    "authors": [
        {
            "affiliation": "Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. maj-britt.raaby.jensen@regionh.dk.",
            "firstname": "M-B",
            "initials": "MB",
            "lastname": "Jensen"
        },
        {
            "affiliation": "Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.\nSection for Bioinformatics, DTU Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.",
            "firstname": "C B",
            "initials": "CB",
            "lastname": "Pedersen"
        },
        {
            "affiliation": "Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.",
            "firstname": "M-A",
            "initials": "MA",
            "lastname": "Misiakou"
        },
        {
            "affiliation": "Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "M-L M",
            "initials": "MM",
            "lastname": "Talman"
        },
        {
            "affiliation": "Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.",
            "firstname": "L",
            "initials": "L",
            "lastname": "Gibson"
        },
        {
            "affiliation": "Department of Clinical Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.",
            "firstname": "U B",
            "initials": "UB",
            "lastname": "Tange"
        },
        {
            "affiliation": "Department of Breast Examinations, Copenhagen University Hospital, Herlev-Gentofte, Copenhagen, Denmark.",
            "firstname": "H",
            "initials": "H",
            "lastname": "Kledal"
        },
        {
            "affiliation": "Department of Breast Examinations, Copenhagen University Hospital, Herlev-Gentofte, Copenhagen, Denmark.",
            "firstname": "I",
            "initials": "I",
            "lastname": "Vejborg"
        },
        {
            "affiliation": "Department of Breast Surgery, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.\nDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "N",
            "initials": "N",
            "lastname": "Kroman"
        },
        {
            "affiliation": "Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.\nDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "F C",
            "initials": "FC",
            "lastname": "Nielsen"
        },
        {
            "affiliation": "Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.\nDepartment of Clinical Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.\nDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "B",
            "initials": "B",
            "lastname": "Ejlertsen"
        },
        {
            "affiliation": "Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.\nDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.",
            "firstname": "M",
            "initials": "M",
            "lastname": "Rossing"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023. The Author(s).",
    "doi": "10.1038/s41523-023-00551-0\n10.1200/JCO.20.03399\n10.1200/JCO.1998.16.8.2672\n10.1016/S0140-6736(13)62422-8\n10.1056/NEJMoa1612645\n10.1056/NEJMoa1814017\n10.1186/s12916-015-0540-z\n10.3390/cancers12082012\n10.1200/JCO.2008.18.1370\n10.1007/s10549-018-5020-7\n10.1245/s10434-018-07107-8\n10.1038/modpathol.2017.41\n10.1038/35021093\n10.1073/pnas.191367098\n10.1038/nature10983\n10.1038/onc.2011.301\n10.1001/jamaoncol.2021.4394\n10.1016/j.annonc.2021.05.804\n10.1056/NEJMoa1904819\n10.1056/NEJMoa2108873\n10.1038/s41379-020-0620-2\n10.1007/s10549-011-1488-0\n10.1245/s10434-016-5600-x\n10.1200/PO.21.00463\n10.1007/s12032-014-0163-9\n10.1200/JCO.2005.02.0818\n10.1007/s10549-007-9590-z\n10.1634/theoncologist.2014-0198\n10.1007/s10549-020-05989-5\n10.1016/j.breast.2021.01.001\n10.1007/s10549-006-9366-x\n10.3233/BD-150199\n10.1016/j.ccell.2022.05.005\n10.1080/0284186X.2017.1398416\n10.1111/j.1600-0463.2011.02871.x\n10.1200/JCO.2018.77.8738\n10.1038/s41598-021-81538-4\n10.1007/s10549-015-3674-y\n10.1093/bioinformatics/btg405\n10.1093/biostatistics/kxj037\n10.1093/bioinformatics/bts034\n10.1002/1878-0261.12389\n10.1093/bioinformatics/bts635\n10.1093/bioinformatics/btt656\n10.1186/s13059-014-0550-8",
    "journal": "NPJ breast cancer",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-06-01",
    "pubmed_id": "37258527\n33507815\n9704717\n24529560\n28564564\n30516102\n26684470\n32708049\n19204204\n30361874\n30542840\n28548119\n10963602\n11553815\n22522925\n21785460\n34617979\n34082017\n31157962\n34914339\n32661297\n21472434\n27770345\n35476550\n25186065\n16145055\n17468949\n25795632\n33150547\n33601299\n17039265\n27662272\n35623341\n29164972\n22429216\n29846122\n33500440\n26740214\n14960456\n16632515\n22257669\n30289602\n23104886\n24227677\n25516281",
    "results": null,
    "title": "Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study.",
    "xml": "<Element 'PubmedArticle' at 0x788504de21b0>"
}