{
    "abstract": "The respiratory effects of lorazepam (a 1, 4 benzodiazepine) were studied using a modified Read rebreathing technique in healthy adult males about to undergo elective surgery. Lorazepam 0.05 mg/kg (IV) produced an increase in slope and a shift to the left of the CO2 response curve. These effects were also detectable but of smaller magnitude when the same lorazepam dose (IV) was given with meperidine (IV). End-expiratory CO2 (PeCO2), which was significantly elevated in all drug groups, is not a sensitive indicator of either the time course or the degree of respiratory depression.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "B A",
            "initials": "BA",
            "lastname": "Paulson"
        },
        {
            "affiliation": null,
            "firstname": "L D",
            "initials": "LD",
            "lastname": "Becker"
        },
        {
            "affiliation": null,
            "firstname": "W L",
            "initials": "WL",
            "lastname": "Way"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1111/j.1399-6576.1983.tb01976.x",
    "journal": "Acta anaesthesiologica Scandinavica",
    "keywords": [],
    "methods": null,
    "publication_date": "1983-10-01",
    "pubmed_id": "6637367",
    "results": null,
    "title": "The effects of intravenous lorazepam alone and with meperidine on ventilation in man.",
    "xml": "<Element 'PubmedArticle' at 0x78850326e390>"
}