{
    "abstract": "This study aimed to compare patient-reported pain scores and clinician-assessed healing outcomes following the treatment of oral leukoplakia (OL) with a diode laser vs. a conventional scalpel.\nA randomized, double-blind clinical trial (Brazilian Clinical Trials Registry (RBR-7pgcyq) was conducted involving histopathologically confirmed OL patients. Participants were randomly allocated to undergo treatment with either a diode laser or a scalpel. Pain was assessed at 24\u2005h, 48\u2005h, and 7 days using the Visual Analog Scale (VAS), while healing outcomes were clinically evaluated at 7 days, 1-month, and 3-months post-treatment using the Vancouver Scar Scale. Statistical analyses included the Mann-Whitney \n64 patients were analyzed (33 in diode laser and 31 in scalpel group). No significant differences in pain scores were observed between the treatment groups at 24\u2005h (\nThere was no significant difference between the diode laser and scalpel treatment arms regarding post operative pain scores. Diode lasers represent better healing at the first week post treatment, but with no differences over time. These findings support the use of either modality as viable management options for OL.\nBrazilian Clinical Trials Registry, identifier (RBR-7pgcyq).",
    "authors": [
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "Mariana",
            "initials": "M",
            "lastname": "de Pauli Paglioni"
        },
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "Caique Mariano",
            "initials": "CM",
            "lastname": "Pedroso"
        },
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "Isabel Schausltz Pereira",
            "initials": "ISP",
            "lastname": "Faustino"
        },
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "Pablo Agustin",
            "initials": "PA",
            "lastname": "Vargas"
        },
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "Mario Fernando",
            "initials": "MF",
            "lastname": "de Goes"
        },
        {
            "affiliation": "Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul-UFRS, Porto Alegre, Brazil.",
            "firstname": "Manoela Domingues",
            "initials": "MD",
            "lastname": "Martins"
        },
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "M\u00e1rcio Ajudarte",
            "initials": "MA",
            "lastname": "Lopes"
        },
        {
            "affiliation": "Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.",
            "firstname": "Alan Roger",
            "initials": "AR",
            "lastname": "Santos-Silva"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 de Pauli Paglioni, Pedroso, Faustino, Vargas, de Goes, Martins, Lopes and Santos-Silva.",
    "doi": "10.3389/froh.2025.1568425\n10.1111/odi.13704\n10.1111/j.1600-0714.2007.00582.x\n10.31557/APJCP.2018.19.12.3635\n10.1111/j.1600-0714.2007.00575.x\n10.1111/odi.14123\n10.1089/pho.2018.4491\n10.5005/jp-journals-10024-2125\n10.15171/jlms.2015.05\n10.4317/medoral.21645\n10.1007/s00784-023-05438-9\n10.1111/odi.14961\n10.1186/1741-7015-8-18\n10.1111/j.1600-0714.2012.01167.x\n10.1097/00004630-199509000-00013\n10.1007/s12663-013-0519-2\n10.4103/jiaomr.jiaomr_4_19\n10.1007/s10103-023-03806-1\n10.7314/apjcp.2015.16.18.8383\n10.4317/jced.53602\n10.1080/00016357.2020.1869826\n10.1016/j.pain.2010.05.013\n10.1097/01.j.pain.0000460352.07836.0d\n10.3390/dj12120420\n10.14295/bds.2021.v24i4.2566\n10.1186/s12903-024-04179-9\n10.1007/s00784-018-2535-6",
    "journal": "Frontiers in oral health",
    "keywords": [
        "diode laser",
        "healing",
        "oral leukoplakia",
        "pain",
        "randomized clinical trial",
        "surgical excision"
    ],
    "methods": null,
    "publication_date": "2025-03-18",
    "pubmed_id": "40098816\n33128420\n17944749\n30583693\n18197849\n34982498\n30339489\n28874640\n26464779\n28809365\n38147181\n38654673\n20619135\n22697318\n8537427\n25018607\n37335418\n26745089\n28638555\n33476210\n20557999\n25790453\n39727477\n38632580\n29971512",
    "results": "64 patients were analyzed (33 in diode laser and 31 in scalpel group). No significant differences in pain scores were observed between the treatment groups at 24\u2005h (",
    "title": "Wound healing and pain evaluation following diode laser surgery vs. conventional scalpel surgery in the surgical treatment of oral leukoplakia: a randomized controlled trial.",
    "xml": "<Element 'PubmedArticle' at 0x7885028e6070>"
}