{
    "abstract": "von Willebrand disease (VWD) represents the most common inherited bleeding disorder. The majority of VWD cases are characterized by partial quantitative reductions in plasma von Willebrand factor (VWF) levels. Management of patients with mild to moderate VWF reductions in the range of 30 to 50\u2009IU/dL poses a common clinical challenge. Some of these low VWF patients present with significant bleeding problems. In particular, heavy menstrual bleeding and postpartum hemorrhage can cause significant morbidity. Conversely, however, many individuals with mild plasma VWF:Ag reductions do not have any bleeding sequelae. In contrast to type 1 VWD, most patients with low VWF do not have detectable pathogenic ",
    "authors": [
        {
            "affiliation": "Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland.\nNational Coagulation Centre, St James's Hospital, Dublin, Ireland.\nIrish-Australian Blood Collaborative (IABC) Network, Dublin, Ireland.",
            "firstname": "James S",
            "initials": "JS",
            "lastname": "O'Donnell"
        },
        {
            "affiliation": "Irish-Australian Blood Collaborative (IABC) Network, Dublin, Ireland.\nWestern Australia Centre for Thrombosis and Haemostasis, Perth Blood Institute, Murdoch University, Perth, Australia.\nHollywood Haemophilia Treatment Centre, Hollywood Hospital, Perth, Australia.",
            "firstname": "Ross I",
            "initials": "RI",
            "lastname": "Baker"
        }
    ],
    "conclusions": null,
    "copyrights": "Thieme. All rights reserved.",
    "doi": "10.1055/a-1980-8198",
    "journal": "Hamostaseologie",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-02-23",
    "pubmed_id": "36807819",
    "results": null,
    "title": "Low von Willebrand Disease: A Bleeding Disorder of Unknown Cause?",
    "xml": "<Element 'PubmedArticle' at 0x788503c92a70>"
}