{
    "abstract": "Mitochondrial dysfunction has been implicated in sarcopenia. \nTwenty Chinese men with sarcopenia (SARC, age\u00a0=\u00a073.1\u00a0\u00b1\u00a04.1\u00a0years) and 19 healthy aged and sex-matched controls (CON, age\u00a0=\u00a070.3\u00a0\u00b1\u00a04.2\u00a0years) underwent assessment of strength, physical performance, and magnetic resonance imaging. Concentrations of phosphocreatine (PCr), ATP and inorganic phosphate (Pi) as well as muscle pH were measured at rest and during an interleaved rest-exercise protocol to probe muscle mitochondrial function. Results were compared to biopsy-derived mitochondrial complex activity and expression to understand underlying metabolic perturbations.\nDespite matched muscle contractile power (strength/cross-sectional area), the ATP contractile cost was higher in SARC compared with CON (low-intensity exercise: 1.06\u00a0\u00b1\u00a00.59 vs. 0.57\u00a0\u00b1\u00a00.22, moderate: 0.93\u00a0\u00b1\u00a00.43 vs. 0.58\u00a0\u00b1\u00a00.68, high: 0.70\u00a0\u00b1\u00a00.57 vs. 0.43\u00a0\u00b1\u00a00.51\u00a0mmol\u00a0L\nThis study used ",
    "authors": [
        {
            "affiliation": "Centre for Translational Medicine (TMR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.",
            "firstname": "Mary C",
            "initials": "MC",
            "lastname": "Stephenson"
        },
        {
            "affiliation": "Centre for Translational Medicine (TMR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.\nDepartment of Radiology, Sengkang Hospital, Singapore, Singapore.",
            "firstname": "Jamie X M",
            "initials": "JXM",
            "lastname": "Ho"
        },
        {
            "affiliation": "Nestl\u00e9 Institute of Health Sciences, Nestl\u00e9 Research, EPFL Innovation Park, 1015, Lausanne, Switzerland.",
            "firstname": "Eugenia",
            "initials": "E",
            "lastname": "Migliavacca"
        },
        {
            "affiliation": "Centre for Translational Medicine (TMR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.",
            "firstname": "Maria",
            "initials": "M",
            "lastname": "Kalimeri"
        },
        {
            "affiliation": "Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.\nDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.",
            "firstname": "Neerja",
            "initials": "N",
            "lastname": "Karnani"
        },
        {
            "affiliation": "Synphne Pte. Ltd, Singapore, Singapore.",
            "firstname": "Subhasis",
            "initials": "S",
            "lastname": "Banerji"
        },
        {
            "affiliation": "IMIV, Bournemouth University, Poole, UK.",
            "firstname": "John J",
            "initials": "JJ",
            "lastname": "Totman"
        },
        {
            "affiliation": "Nestl\u00e9 Institute of Health Sciences, Nestl\u00e9 Research, EPFL Innovation Park, 1015, Lausanne, Switzerland.\nEPFL School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.",
            "firstname": "Jerome N",
            "initials": "JN",
            "lastname": "Feige"
        },
        {
            "affiliation": "Division of Geriatric Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore.",
            "firstname": "Reshma A",
            "initials": "RA",
            "lastname": "Merchant"
        },
        {
            "affiliation": "Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.\nKTP-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore, Singapore.",
            "firstname": "Stacey K H",
            "initials": "SKH",
            "lastname": "Tay"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.",
    "doi": "10.1002/jcsm.13220",
    "journal": "Journal of cachexia, sarcopenia and muscle",
    "keywords": [
        "Mitochondrial complex activity",
        "Mitochondrial function",
        "Muscle",
        "Sarcopenia",
        "Spectroscopy"
    ],
    "methods": null,
    "publication_date": "2023-05-05",
    "pubmed_id": "37143433\n14608013\n8368290\n8498491\n20164314\n14555665\n24852668\n30498820\n26520231\n14687319\n31862890\n30687111\n5016631\n16909385\n12496142\n19959566\n15800038\n16002769\n23051977\n10878112\n31031645\n30266472\n32468656\n37118369\n26410107\n24461239\n9405214\n8133746\n4743524\n22354667\n15576045\n26039449\n9310077\n8457430\n19066935\n22434070\n16301222\n29098794\n17628042\n7012859",
    "results": "Despite matched muscle contractile power (strength/cross-sectional area), the ATP contractile cost was higher in SARC compared with CON (low-intensity exercise: 1.06\u00a0\u00b1\u00a00.59 vs. 0.57\u00a0\u00b1\u00a00.22, moderate: 0.93\u00a0\u00b1\u00a00.43 vs. 0.58\u00a0\u00b1\u00a00.68, high: 0.70\u00a0\u00b1\u00a00.57 vs. 0.43\u00a0\u00b1\u00a00.51\u00a0mmol\u00a0L",
    "title": "Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopy.",
    "xml": "<Element 'PubmedArticle' at 0x788502c1d8a0>"
}