{
    "abstract": "The global dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) poses a critical threat to public health. However, comprehensive data on the prevalence and resistance rates of CR-hvKp are limited. This systematic review and meta-analysis aim to estimate the pooled prevalence of carbapenem resistance among hvKp strains and assess the distribution of carbapenemase genes.\nA systematic search of ISI Web of Science, PubMed, and Google Scholar was conducted to identify studies reporting carbapenem resistance rates in hvKp strains. The pooled prevalence of carbapenem resistance and carbapenemase genes was calculated using event rates with 95% confidence intervals.\nA total of 36 studies encompassing 1,098 hvKp strains were included. The pooled resistance rates were 49% for imipenem, 53.2% for meropenem, and 38.2% for ertapenem. Carbapenemase gene prevalence was 19.1% for bla\nThe high prevalence of carbapenem resistance and the widespread distribution of carbapenemase genes among hvKp strains underscore their significant threat to global health. These findings highlight the urgent need for enhanced surveillance, rapid diagnostic tools, and stringent infection control measures to mitigate the spread of CR-hvKp. Future research should focus on understanding resistance mechanisms and developing targeted therapeutic strategies to address this critical challenge.",
    "authors": [
        {
            "affiliation": "Paramedical Faculty of Iranshahr, Iranshahr, Iran.",
            "firstname": "Motahareh Sabaghi",
            "initials": "MS",
            "lastname": "Qala Nou"
        },
        {
            "affiliation": "Department of Surgery, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.",
            "firstname": "Zahra",
            "initials": "Z",
            "lastname": "Amirian"
        },
        {
            "affiliation": "Department of Pediatrics, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.",
            "firstname": "Fatemeh",
            "initials": "F",
            "lastname": "Dehghani"
        },
        {
            "affiliation": "Department of General Surgery, Imam Ali Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.",
            "firstname": "Amir-Kazem",
            "initials": "AK",
            "lastname": "Vejdan"
        },
        {
            "affiliation": "Critical Care Nursing, Department of Nursing, School of Nursing and Midwifery, Iranshahr University of Medical Sciences, Iranshahr, Iran.",
            "firstname": "Roghayeh",
            "initials": "R",
            "lastname": "Rooin"
        },
        {
            "affiliation": "Medical Surgical Nursing, Department of Nursing, School of Nursing and Midwifery, Iranshahr University of Medical Sciences, Iranshahr, Iran. sadeghdehghan3407@gmail.com.",
            "firstname": "Sadegh",
            "initials": "S",
            "lastname": "Dehghanmehr"
        }
    ],
    "conclusions": "The high prevalence of carbapenem resistance and the widespread distribution of carbapenemase genes among hvKp strains underscore their significant threat to global health. These findings highlight the urgent need for enhanced surveillance, rapid diagnostic tools, and stringent infection control measures to mitigate the spread of CR-hvKp. Future research should focus on understanding resistance mechanisms and developing targeted therapeutic strategies to address this critical challenge.",
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1186/s40360-025-00857-8\n10.1186/s12866-023-03022-5",
    "journal": "BMC pharmacology & toxicology",
    "keywords": [
        "K. pneumoniae",
        "Antibiotic resistance",
        "Carbapenem",
        "Hypervirulent K. pneumoniae"
    ],
    "methods": null,
    "publication_date": "2025-01-31",
    "pubmed_id": "39885589\n23253318\n29312894\n9767057\n31092506\n30380384\n28233784\n26199326\n37957579\n31677303\n37589017\n37248259\n23302790\n35244778\n35297657\n25341126\n30595129\n11257029\n39009596\n34064302\n36380387\n24766095\n24959688\n22480775\n28167547\n30423057\n32234050\n29906566\n34011682\n24982067\n29319515\n29981456\n30410479\n30250833\n30078963\n29238932\n30128143\n30430779\n31408411\n31782273\n31533609\n30665418\n32256482\n32982325\n33116694\n33163077\n32611369\n34690977\n34589442\n34540792\n34465335\n35573787\n35522153\n36176583\n36406386\n35309213\n36721517\n36374105\n36043878\n35042478\n36985277\n36752639\n36824066\n36882683\n36748017\n28356109\n28276996\n36868960\n16423491\n12392901\n20973725\n23142195\n39069234\n22499996\n26862399\n27334661\n25542046\n36356348\n28375512\n29267233\n28652234\n25304194\n17261621\n26106476\n28736270\n27413192\n35856662\n38758189\n25926236\n26407326\n28785421\n22000347\n25261423\n24021566\n24215473\n33188415\n28340557\n34357049\n38236906\n37589017\n21115786\n36278643\n38014944\n32120036\n37764066\n33484895",
    "results": "A total of 36 studies encompassing 1,098 hvKp strains were included. The pooled resistance rates were 49% for imipenem, 53.2% for meropenem, and 38.2% for ertapenem. Carbapenemase gene prevalence was 19.1% for bla",
    "title": "Systematic review and meta-analysis on the carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates.",
    "xml": "<Element 'PubmedArticle' at 0x788506484bd0>"
}