{
    "abstract": "Aqueous extract of unripe \nAqueous extracts obtained by maceration were analyzed for acute and subacute toxicity and for the presence of phytochemical constituents using standard procedures. The extract (100, 500, and 1000\u2005mg/kg) was administered daily to rats of both sexes for 28 d. Blood samples collected on days 0 and 28 were assessed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA). Testes and ovaries were harvested for histopathological analysis. Sperm were also collected to determine the sperm count and motility.\nPhytochemical screening revealed the presence of saponins, tannins, alkaloids, and resins. After an oral dose of up to 5000\u2005mg/kg, there were no deaths in the acute toxicity test. The extract (500\u2005mg/kg) significantly (\nUnripe ",
    "authors": [
        {
            "affiliation": "Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.",
            "firstname": "Collins Azubuike",
            "initials": "CA",
            "lastname": "Onyeto"
        },
        {
            "affiliation": "Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.",
            "firstname": "Akachukwu Marytheresa",
            "initials": "AM",
            "lastname": "Onwuka"
        },
        {
            "affiliation": "Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.",
            "firstname": "Ikechukwu Emmanuel",
            "initials": "IE",
            "lastname": "Peter"
        },
        {
            "affiliation": "Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.",
            "firstname": "Chukwuemeka Sylvester",
            "initials": "CS",
            "lastname": "Nworu"
        },
        {
            "affiliation": "Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.",
            "firstname": "Peter Achunike",
            "initials": "PA",
            "lastname": "Akah"
        }
    ],
    "conclusions": "Unripe ",
    "copyrights": null,
    "doi": "10.1177/2515690X241249534",
    "journal": "Journal of evidence-based integrative medicine",
    "keywords": [
        "Musa paradisiaca",
        "aqueous extract",
        "ovary",
        "rodents",
        "testes",
        "toxicity"
    ],
    "methods": null,
    "publication_date": "2024-04-29",
    "pubmed_id": "38679583\n34628616\n12507252\n34023819\n23798793\n34527068\n6667118\n14209117\n34075227\n4215654\n6727660\n34097903\n22082982\n33832492\n35178873\n35203298\n33577784\n35111049\n34439468\n28620474",
    "results": "Phytochemical screening revealed the presence of saponins, tannins, alkaloids, and resins. After an oral dose of up to 5000\u2005mg/kg, there were no deaths in the acute toxicity test. The extract (500\u2005mg/kg) significantly (",
    "title": "Effect of Aqueous Extract of Unripe ",
    "xml": "<Element 'PubmedArticle' at 0x788506acc400>"
}