{
    "abstract": "ApoE abnormality represents a well-known risk factor for cardiovascular diseases. Beyond its role in lipid metabolism, novel studies demonstrate a complex involvement of apoE in membrane homeostasis and signaling as well as in nuclear transcription. Due to the large spread of apoE isoforms in the human population, there is a need to understand the apoE's role in pathological processes. Our study aims to dissect the involvement of apoE in heart failure. We showed that apoE-deficient rats present multiple organ damages (kidney, liver, lung and spleen) besides the known predisposition for obesity and affected lipid metabolism (two-fold increase in tissular damages in liver and one-fold increase in kidney, lung and spleen). Heart tissue also showed significant morphological changes in apoE",
    "authors": [
        {
            "affiliation": "Human Genetic Laboratory, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.\nDepartment of Cardiology, University of Medicine and Pharmacy, 200349 Craiova, Romania.",
            "firstname": "Rodica",
            "initials": "R",
            "lastname": "Diaconu"
        },
        {
            "affiliation": "Department of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "Nicole",
            "initials": "N",
            "lastname": "Schaaps"
        },
        {
            "affiliation": "Department of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.\nDepartment of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.",
            "firstname": "Mamdouh",
            "initials": "M",
            "lastname": "Afify"
        },
        {
            "affiliation": "Medical Faculty, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "Peter",
            "initials": "P",
            "lastname": "Boor"
        },
        {
            "affiliation": "Department of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "Anne",
            "initials": "A",
            "lastname": "Cornelissen"
        },
        {
            "affiliation": "Department of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "Roberta A",
            "initials": "RA",
            "lastname": "Florescu"
        },
        {
            "affiliation": "Department for Pharmacology and Clinical Pharmacology, Medical Faculty, University Hospital D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany.",
            "firstname": "Sakine",
            "initials": "S",
            "lastname": "Simsekyilmaz"
        },
        {
            "affiliation": "Department of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "Teddy",
            "initials": "T",
            "lastname": "El-Khoury"
        },
        {
            "affiliation": "Department of Anesthesiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.\nMedical Faculty, Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "David",
            "initials": "D",
            "lastname": "Schumacher"
        },
        {
            "affiliation": "Human Genetic Laboratory, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.",
            "firstname": "Mihai",
            "initials": "M",
            "lastname": "Ioana"
        },
        {
            "affiliation": "Human Genetic Laboratory, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.",
            "firstname": "Ioana",
            "initials": "I",
            "lastname": "Streata"
        },
        {
            "affiliation": "Department of Cardiology, University of Medicine and Pharmacy, 200349 Craiova, Romania.",
            "firstname": "Constantin",
            "initials": "C",
            "lastname": "Militaru"
        },
        {
            "affiliation": "Department of Cardiology, University of Medicine and Pharmacy, 200349 Craiova, Romania.",
            "firstname": "Ionut",
            "initials": "I",
            "lastname": "Donoiu"
        },
        {
            "affiliation": "Department of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.",
            "firstname": "Felix",
            "initials": "F",
            "lastname": "Vogt"
        },
        {
            "affiliation": "Human Genetic Laboratory, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.\nDepartment of Cardiology, Angiology and Intensive Care, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.\nMedical Faculty, Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.\nInstitute for Pathology \"Victor Babes\", 050096 Bucharest, Romania.",
            "firstname": "Elisa A",
            "initials": "EA",
            "lastname": "Liehn"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ijms22189688\n10.1097/01.ASN.0000045048.71975.FC\n10.1186/s12967-016-0901-1\n10.1194/jlr.R067249\n10.1016/j.arcmed.2018.08.008\n10.3390/genes10030222\n10.1038/s41572-019-0084-1\n10.1038/s41598-019-54541-z\n10.1177/0300985813485099\n10.1046/j.1365-2559.1998.00495.x\n10.4254/wjh.v9.i24.1030\n10.15190/d.2019.7\n10.15190/d.2019.12\n10.1093/ehjci/jev014\n10.1016/S0022-2275(20)42257-6\n10.1042/bj2940001\n10.1111/j.1471-4159.2010.07017.x\n10.1016/j.ijcard.2015.12.008\n10.4103/aja.aja_80_20\n10.1194/jlr.M300097-JLR200\n10.1074/jbc.M306923200\n10.1038/nature11087\n10.1016/j.yjmcc.2007.07.054\n10.1074/jbc.M409324200\n10.1002/jcb.240540306\n10.1089/rej.2012.1383\n10.1016/j.pharmthera.2009.05.002\n10.1023/a:1002861008363\n10.1523/JNEUROSCI.3562-15.2016\n10.1016/j.jacc.2011.08.034\n10.1385/jmn:22:3:199\n10.1016/j.ymthe.2017.07.017\n10.18632/aging.102218\n10.3390/ijms20092222\n10.1093/cvr/cvx146\n10.1016/S1071-9164(99)90034-9\n10.1002/ccd.1810350105\n10.1186/s13293-017-0129-7\n10.1165/rcmb.2016-0060TR\n10.1177/2045893217752328",
    "journal": "International journal of molecular sciences",
    "keywords": [
        "apoE",
        "cardiovascular models",
        "dilated cardiomyopathy",
        "right ventricular systolic dysfunction",
        "\u03b54 allele"
    ],
    "methods": null,
    "publication_date": "2021-09-29",
    "pubmed_id": "34575848\n12538731\n27207171\n27015743\n30213474\n30884759\n16714771\n31073128\n31796798\n23558974\n9762541\n28932349\n32309612\n32309617\n25712077\n2010690\n8363559\n21214553\n26730840\n33433530\n12754278\n14507923\n22622580\n17869266\n15485881\n8200910\n23216585\n19460403\n11173514\n26791201\n22115639\n14997013\n28822689\n31484164\n31064116\n28957531\n10404351\n7614536\n28344760\n27073971\n29261014",
    "results": null,
    "title": "Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study.",
    "xml": "<Element 'PubmedArticle' at 0x788506ce9850>"
}