{
    "abstract": "Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as a model to analyze heat stress and effect of chemical compounds on responses to heat stress. The temperature adaptation limit of zebrafish embryos was 37\u00a0\u00b0C in behavioural test and 38\u00a0\u00b0C in cardiac test. Polyaromatic hydrocarbon phenanthrene completely blocked the behavioural adaptation to heat stress. Interestingly, the cardiotoxic effects of lapatinib, phenanthrene and paclitaxel were induced by heat stress. Taken together, our data indicates that motility and cardiac function of zebrafish embryos can be utilized as a model to analyze modulatory effects of compounds on heat stress.",
    "authors": [
        {
            "affiliation": "Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland; Turku Doctoral Programme of Molecular Medicine (TuDMM), University of Turku, Turku, Finland.",
            "firstname": "Anna-Mari",
            "initials": "AM",
            "lastname": "Haapanen-Saaristo"
        },
        {
            "affiliation": "Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland; Faculty of Science and Engineering, Bioscience, \u00c5bo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, \u00c5bo Akademi University and University of Turku, Turku, Finland.",
            "firstname": "Noora",
            "initials": "N",
            "lastname": "Virtanen"
        },
        {
            "affiliation": "University of Turku, Department of Cell Biology and Anatomy, Institute of Biomedicine, Finland; Medicity Research Laboratories and Institute of Biomedicine, University of Turku, Finland.",
            "firstname": "Elena",
            "initials": "E",
            "lastname": "Tcarenkova"
        },
        {
            "affiliation": "Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland; Medicity Research Laboratories and Institute of Biomedicine, University of Turku, Finland.",
            "firstname": "Katri",
            "initials": "K",
            "lastname": "Vaparanta"
        },
        {
            "affiliation": "Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.",
            "firstname": "Minna",
            "initials": "M",
            "lastname": "Ampuja"
        },
        {
            "affiliation": "Department of Biology, University of Turku, Finland.",
            "firstname": "Eeva-Riikka",
            "initials": "ER",
            "lastname": "Vehni\u00e4inen"
        },
        {
            "affiliation": "Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland. Electronic address: ilkka.paatero@utu.fi.",
            "firstname": "Ilkka",
            "initials": "I",
            "lastname": "Paatero"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2024 The Authors. Published by Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.bbrc.2024.150682",
    "journal": "Biochemical and biophysical research communications",
    "keywords": [
        "Behaviour",
        "Cardiac biology",
        "Heat stress",
        "Heat stroke",
        "Zebrafish embryo"
    ],
    "methods": null,
    "publication_date": "2024-09-15",
    "pubmed_id": "39276696",
    "results": null,
    "title": "Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity.",
    "xml": "<Element 'PubmedArticle' at 0x7885033b57b0>"
}