{
    "abstract": "To date, the research on dendritic cells (DCs) and their correlated neoplasms has not been clear. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) and mature plasmacytoid dendritic cell proliferation (MPDCP) are two types of malignancies originating from plasmacytoid dendritic cells (pDCs). Some evidence has indicated the existence of other pDC neoplasms. In addition, cases of myeloid neoplasms (MNs), acute myeloblastic leukemia (AML), and myelodysplastic syndrome (MDS) with increased pDCs (AML/MDS-pDCs) seem to have immature DCs according to the vaguely consistent expression of markers among MNs and pDCs, which appear to fit the developmental pattern of normal DCs. We analyzed 14 AML/MDS-pDC cases mainly for their immunophenotype by flow cytometry and inferred their CD expression pattern. The patients' clinical information and other laboratory data were collected and reviewed. AML/MDS-pDCs show a different pattern of markers from BPDCN and MPDCP. Three maturation-involved stages were found in these AML/MDS-pDCs patients. Stage I was the most immature stage and displayed an expression profile of CD34",
    "authors": [
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.\nDepartment of Clinical Laboratory, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Yuelu District, Changsha, Hunan, 410013, China.",
            "firstname": "Yumei",
            "initials": "Y",
            "lastname": "Huang"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Yazhe",
            "initials": "Y",
            "lastname": "Wang"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Yan",
            "initials": "Y",
            "lastname": "Chang"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Xiaoying",
            "initials": "X",
            "lastname": "Yuan"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Le",
            "initials": "L",
            "lastname": "Hao"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Hongxia",
            "initials": "H",
            "lastname": "Shi"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Yueyun",
            "initials": "Y",
            "lastname": "Lai"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Xiaojun",
            "initials": "X",
            "lastname": "Huang"
        },
        {
            "affiliation": "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, China.",
            "firstname": "Yanrong",
            "initials": "Y",
            "lastname": "Liu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2019 International Society for Advancement of Cytometry.",
    "doi": "10.1002/cyto.a.23953",
    "journal": "Cytometry. Part A : the journal of the International Society for Analytical Cytology",
    "keywords": [
        "BPDCN",
        "MPDCP",
        "PPMD",
        "flow cytometry",
        "maturation",
        "plasmacytoid dendritic cell"
    ],
    "methods": null,
    "publication_date": "2019-12-27",
    "pubmed_id": "31876105",
    "results": null,
    "title": "Myeloid Neoplasms with Elevated Plasmacytoid Dendritic Cell Differentiation Reflect the Maturation Process of Dendritic Cells.",
    "xml": "<Element 'PubmedArticle' at 0x788503e62bb0>"
}