{
    "abstract": "This study aimed to reassess the effect of prophylactic transcervical amnioinfusion for intrapartum meconium-stained amniotic fluid on meconium aspiration syndrome and other adverse neonatal and maternal outcomes.\nFrom inception to November 2021, a systematic search of the literature was performed in PubMed, Embase, Web of Science, and Scopus databases and gray literature sources.\nWe identified randomized controlled trials of patients with intrapartum moderate to thick meconium-stained amniotic fluid that evaluated the effect of amnioinfusion on adverse neonatal and maternal outcomes.\nOf note, 2 reviewers independently abstracted data and gauged study quality by assigning a modified Jadad score. Meconium aspiration syndrome constituted the primary outcome. The secondary outcomes were meconium below the cords, Apgar scores of <7 at 5 minutes, neonatal acidosis, cesarean delivery, cesarean delivery for fetal heart rate abnormalities, neonatal intensive care unit admission, and postpartum endometritis. This study calculated the odds ratios with 95% confidence intervals for categorical outcomes and weighted mean differences with 95% confidence intervals for continuous outcomes.\nA total of 24 randomized studies with 5994 participants met the inclusion criteria. The overall odds of meconium aspiration syndrome was reduced by 67% in the amnioinfusion group (pooled odds ratio, 0.33; 95% confidence interval, 0.21-0.51). Except for postpartum endometritis, amnioinfusion was associated with a significant reduction in all secondary outcomes.\nOur study found that the use of intrapartum amnioinfusion in the setting of meconium-stained amniotic fluid significantly reduces the odds of meconium aspiration syndrome and other adverse neonatal outcomes.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL.",
            "firstname": "Jessica D",
            "initials": "JD",
            "lastname": "Davis"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL. Electronic address: luis.sanchez@jax.ufl.edu.",
            "firstname": "Luis",
            "initials": "L",
            "lastname": "Sanchez-Ramos"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL.",
            "firstname": "Jordan A",
            "initials": "JA",
            "lastname": "McKinney"
        },
        {
            "affiliation": "Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ; Department of Statistics, Florida State University, Tallahassee, FL.",
            "firstname": "Lifeng",
            "initials": "L",
            "lastname": "Lin"
        },
        {
            "affiliation": "Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL.",
            "firstname": "Andrew M",
            "initials": "AM",
            "lastname": "Kaunitz"
        }
    ],
    "conclusions": "Our study found that the use of intrapartum amnioinfusion in the setting of meconium-stained amniotic fluid significantly reduces the odds of meconium aspiration syndrome and other adverse neonatal outcomes.",
    "copyrights": "Copyright \u00a9 2022 Elsevier Inc. All rights reserved.",
    "doi": "10.1016/j.ajog.2022.07.047",
    "journal": "American journal of obstetrics and gynecology",
    "keywords": [
        "amnioinfusion",
        "meconium aspiration syndrome",
        "meconium-stained amniotic fluid"
    ],
    "methods": null,
    "publication_date": "2023-05-11",
    "pubmed_id": "37164492",
    "results": "A total of 24 randomized studies with 5994 participants met the inclusion criteria. The overall odds of meconium aspiration syndrome was reduced by 67% in the amnioinfusion group (pooled odds ratio, 0.33; 95% confidence interval, 0.21-0.51). Except for postpartum endometritis, amnioinfusion was associated with a significant reduction in all secondary outcomes.",
    "title": "Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788503892f70>"
}