{
    "abstract": "Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are well-established therapeutics for gastrointestinal neoplasias, but complications after EMR/ESD, including bleeding and perforation, result in additional treatment morbidity and even threaten the lives of patients. Thus, designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge. Herein, a series of injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) and AA-g-N-hydroxysuccinimide (AA-NHS) were developed, and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model. The hydrogels showed a suitable gelation time, an autonomous and efficient self-healing capacity, hemostatic properties, and good biocompatibility. With the introduction of AA-NHS as a micro-cross-linker, the hydrogels exhibited enhanced adhesive strength. A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding. A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition, \u03b1-SMA expression, and blood vessel formation. These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.",
    "authors": [
        {
            "affiliation": "Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.\nFrontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.\nKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.",
            "firstname": "Jiahui",
            "initials": "J",
            "lastname": "He"
        },
        {
            "affiliation": "Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.\nFrontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.\nKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.\nDepartment of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.",
            "firstname": "Zixi",
            "initials": "Z",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.",
            "firstname": "Yutong",
            "initials": "Y",
            "lastname": "Yang"
        },
        {
            "affiliation": "National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.",
            "firstname": "Fenggang",
            "initials": "F",
            "lastname": "Ren"
        },
        {
            "affiliation": "Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.",
            "firstname": "Jipeng",
            "initials": "J",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.",
            "firstname": "Shaojun",
            "initials": "S",
            "lastname": "Zhu"
        },
        {
            "affiliation": "National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.",
            "firstname": "Feng",
            "initials": "F",
            "lastname": "Ma"
        },
        {
            "affiliation": "National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.",
            "firstname": "Rongqian",
            "initials": "R",
            "lastname": "Wu"
        },
        {
            "affiliation": "National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.",
            "firstname": "Yi",
            "initials": "Y",
            "lastname": "Lv"
        },
        {
            "affiliation": "Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.\nKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.",
            "firstname": "Gang",
            "initials": "G",
            "lastname": "He"
        },
        {
            "affiliation": "Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. baoling@mail.xjtu.edu.cn.\nFrontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China. baoling@mail.xjtu.edu.cn.\nKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China. baoling@mail.xjtu.edu.cn.",
            "firstname": "Baolin",
            "initials": "B",
            "lastname": "Guo"
        },
        {
            "affiliation": "Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. chudake@xjtu.edu.cn.",
            "firstname": "Dake",
            "initials": "D",
            "lastname": "Chu"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1007/s40820-020-00585-0\n10.3322/caac.21492\n10.1016/S2468-1253(19)30347-4\n10.1016/S2468-1253(19)30328-0\n10.1016/S1470-2045(19)30637-0\n10.1136/gutjnl-2019-319925\n10.1007/s00464-013-3356-y\n10.1177/2050640619825968\n10.5946/ce.2013.46.5.456\n10.1016/j.dld.2019.07.001\n10.1007/s00464-019-06719-9\n10.1016/j.gie.2013.01.020\n10.1371/journal.pone.0216829\n10.1002/adma.201500762\n10.1016/j.biomaterials.2018.08.044\n10.1039/C7SC03913A\n10.1016/j.ejps.2014.09.018\n10.1002/smll.201900046\n10.1016/j.ejpb.2004.03.019\n10.1021/acs.molpharmaceut.6b01104\n10.1016/j.addr.2018.03.007\n10.1021/bm200326g\n10.1021/acs.biomac.5b01566\n10.1016/j.biomaterials.2018.10.047\n10.1016/j.biomaterials.2017.01.011\n10.1016/j.jcis.2018.10.056\n10.1016/j.biomaterials.2017.05.011\n10.1016/j.jcis.2019.08.083\n10.1038/boneres.2017.14\n10.1016/j.carbpol.2017.11.109\n10.1038/s41467-019-08355-2\n10.1039/C9NR09283H\n10.4166/kjg.2019.74.6.326\n10.1021/acs.biomac.8b00819\n10.1016/j.cej.2019.01.028\n10.1039/C9TB00481E\n10.1016/j.carbpol.2018.08.090\n10.1016/j.ijbiomac.2016.12.070\n10.1073/pnas.1201122109\n10.1016/j.actbio.2018.12.008\n10.1021/acs.chemmater.0c02030\n10.1016/j.carbpol.2013.12.017\n10.1007/s00464-018-6521-5\n10.3748/wjg.v23.i43.7746\n10.1021/acsnano.6b05318\n10.1039/C8SM01575A\n10.1080/17425247.2017.1360865\n10.1080/10717544.2017.1279238\n10.1016/j.cej.2017.07.022\n10.1007/s00268-003-6831-0\n10.1002/adma.201905761\n10.1016/j.ejpb.2019.02.017\n10.1021/acsami.7b10583\n10.1016/j.actbio.2018.03.018\n10.1016/j.biomaterials.2016.07.011\n10.1002/jat.727\n10.1021/acsabm.8b00189\n10.1002/smll.201901566\n10.1016/j.gastre.2019.02.015\n10.1182/bloodadvances.2016004150\n10.1136/vr.157.17.510",
    "journal": "Nano-micro letters",
    "keywords": [
        "Adhesive hydrogel",
        "Endoscopic treatment",
        "Gastric hemostasis",
        "Gastric wound healing",
        "Injectable self-healing hydrogel"
    ],
    "methods": null,
    "publication_date": "2021-06-18",
    "pubmed_id": "34138263\n30207593\n31648972\n31648970\n31591062\n31586933\n24442676\n31316782\n24143302\n31401022\n30820658\n23582528\n31185029\n25953204\n30172244\n29719691\n25277680\n30786150\n15296964\n28207269\n29567395\n21591793\n26607961\n30497024\n28107663\n30368094\n28579065\n31473541\n28584674\n29254010\n30700712\n31859313\n31870138\n30005160\n30241849\n28057575\n22392977\n30528606\n24528707\n30350104\n29209115\n28245107\n30187054\n28771375\n28195032\n14648041\n31625635\n30898541\n28812353\n29555459\n27424213\n11180276\n34996234\n31304670\n30459058\n29296720\n16244233",
    "results": null,
    "title": "Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing.",
    "xml": "<Element 'PubmedArticle' at 0x7885039a2110>"
}