{
    "abstract": "Cerebral venous thrombosis (CVT) has various risk factors, including contraception, pregnancy, neoplasia, and thrombophilia. Nitrous oxide (N\u2082O), historically used as an anesthetic and more recently as a recreational drug, has been associated with neurological complications such as myeloneuropathy and thromboembolic events. Here, we report two cases of CVT associated with N\u2082O use and provide a review of the literature on this association.\nWe describe two local cases of CVT associated with N\nAmong the 12 patients, seven had co-existing CVT risk factors. Most patients reported chronic N\nThese cases highlight an emerging association between CVT and N\u2082O use. Prompt recognition of this link is critical to recommend cessation of N\u2082O use, alongside anticoagulation therapy and consideration of vitamin supplementation to prevent complications and recurrence.",
    "authors": [
        {
            "affiliation": "Neurology Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nFHU NeuroVasc, Paris, France.\nUniversit\u00e9 Paris Cit\u00e9, Paris, France.",
            "firstname": "Diana",
            "initials": "D",
            "lastname": "Doukhi"
        },
        {
            "affiliation": "Universit\u00e9 Paris Cit\u00e9, Paris, France.\nINSERM, U1140, Paris, France.\nHematology Laboratory Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.",
            "firstname": "Virginie",
            "initials": "V",
            "lastname": "Siguret"
        },
        {
            "affiliation": "M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Charles Nicolle, Rouen, France.\nU.F.R. de m\u00e9decine, Universit\u00e9 Rouen Normandie, Rouen, France.\nINSERM, U1096, Universit\u00e9 Rouen Normandie, Rouen, France.",
            "firstname": "Dominique",
            "initials": "D",
            "lastname": "Vodovar"
        },
        {
            "affiliation": "Hematology Laboratory Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nINSERM, U1144, Paris, France.",
            "firstname": "Maxime",
            "initials": "M",
            "lastname": "Delrue"
        },
        {
            "affiliation": "Neurology Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nFHU NeuroVasc, Paris, France.",
            "firstname": "Peggy",
            "initials": "P",
            "lastname": "Reiner"
        },
        {
            "affiliation": "Neurology Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nFHU NeuroVasc, Paris, France.",
            "firstname": "Agnes",
            "initials": "A",
            "lastname": "Aghetti"
        },
        {
            "affiliation": "Neurology Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nFHU NeuroVasc, Paris, France.\nUniversit\u00e9 Paris Cit\u00e9, Paris, France.\nCentre de R\u00e9f\u00e9rence des Maladies Vasculaires Rares du Cerveau et de l'Oeil (CERVCO), H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.",
            "firstname": "St\u00e9phanie",
            "initials": "S",
            "lastname": "Guey"
        },
        {
            "affiliation": "Neurology Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nFHU NeuroVasc, Paris, France.\nUniversit\u00e9 Paris Cit\u00e9, Paris, France.\nINSERM, U1144, Paris, France.\nCentre de R\u00e9f\u00e9rence des Maladies Vasculaires Rares du Cerveau et de l'Oeil (CERVCO), H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nInterventional Neuroradiology Department, H\u00f4pital Fondation A. de Rothschild, Paris, France.",
            "firstname": "Mikael",
            "initials": "M",
            "lastname": "Mazighi"
        },
        {
            "affiliation": "Neurology Department, H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.\nFHU NeuroVasc, Paris, France.\nCentre de R\u00e9f\u00e9rence des Maladies Vasculaires Rares du Cerveau et de l'Oeil (CERVCO), H\u00f4pital Lariboisi\u00e8re, APHP, Paris, France.",
            "firstname": "Isabelle",
            "initials": "I",
            "lastname": "Crassard"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.",
    "doi": "10.1002/brb3.70394\n10.7759/cureus.41428\n10.1161/01.STR.0000132570.24618.78\n10.1016/j.revmed.2021.10.008\n10.1016/j.jtha.2022.10.002\n10.1136/jcp.33.10.909\n10.1161/STROKEAHA.112.671453\n10.1056/NEJM199603213341203\n10.1182/blood-2006-04-014654\n10.1136/bcr-2021-244478\n10.1016/j.jstrokecerebrovasdis.2017.04.020\n10.7861/clinmed.2022-0516\n10.1159/000518524\n10.1016/j.thromres.2018.07.005\n10.3389/fpubh.2023.1167746\n10.3892/mi.2022.45\n10.1186/s12883-020-01961-4\n10.1136/bmjno-2023-000619\n10.1016/j.heliyon.2023.e13473\n10.1007/s11239-019-02010-9\n10.7326/0003-4819-146-11-200706050-00157\n10.1038/nrneurol.2017.104\n10.1111/ene.15077\n10.3389/fneur.2021.753110",
    "journal": "Brain and behavior",
    "keywords": [
        "cerebral venous thrombosis",
        "drug",
        "homocysteine",
        "nitrous oxide",
        "vitamin B12"
    ],
    "methods": null,
    "publication_date": "2025-03-01",
    "pubmed_id": "40022289\n37546135\n15192249\n34903366\n36700505\n6107306\n22996960\n8592549\n16960155\n34400432\n28583818\n36958828\n34515072\n30005273\n37206871\n36698503\n33081755\n38757110\n36825186\n31820264\n17470822\n28820187\n34427020\n34819911",
    "results": "Among the 12 patients, seven had co-existing CVT risk factors. Most patients reported chronic N",
    "title": "Cerebral Venous Thrombosis and Nitrous Oxide Intoxication: Report of Two Cases and Review of the Literature.",
    "xml": "<Element 'PubmedArticle' at 0x788505c90ea0>"
}