{
    "abstract": "Myeloproliferative neoplasms (MPNs) can be classified into two major categories, namely chronic myeloid leukaemia (CML) and Philadelphia-negative MPNs (PN-MPNs). BCR- ABL1 reassortment is an irreplaceable indicator for the diagnosis of typical CML, while the V617F mutation on the Janus kinase 2 (JAK2) gene is common in PN-MPNs patients. Generally, these two genetic abnormalities are considered unable to coexist. We report a patient with CML who had both genetic changes, suggesting that when tyrosine kinase inhibitors (TKIs) monotherapy cannot obtain satisfactory treatment outcomes in CML patients, another possibility besides disease progression is a mutation on the JAK2 V617F gene.",
    "authors": [
        {
            "affiliation": "School of Clinical Medicine, College of Medicine, Shandong University, No. 44 Cultural West Road, Lixia district, Jinan-250012, Shandong province, China.",
            "firstname": "Jianjun Yang",
            "initials": "JY",
            "lastname": "Cheeloo"
        },
        {
            "affiliation": "Department of Haematology, The First Affiliated Hospital of Shandong First Medical University, No. 16766 Jingshi Road, Wendong Street, Lixia District, Jinan 250014, Shandong province, China.",
            "firstname": "Kehong",
            "initials": "K",
            "lastname": "Bi"
        },
        {
            "affiliation": "School of Clinical Medicine, College of Medicine, Shandong University, No. 44 Cultural West Road, Lixia district, Jinan-250012, Shandong province, China.",
            "firstname": "Zhaoguang",
            "initials": "Z",
            "lastname": "Zhang"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.25259/NMJI_61_2022",
    "journal": "The National medical journal of India",
    "keywords": [],
    "methods": null,
    "publication_date": "2025-04-21",
    "pubmed_id": "40257161",
    "results": null,
    "title": "Coexistence of BCR-ABL1 reassortment and JAK2 V617F mutation in chronic myeloid leukaemia.",
    "xml": "<Element 'PubmedArticle' at 0x788502e76840>"
}