{
    "abstract": "Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential of gallic acid (GA)-derived PGA-Cu nanoparticles, enhanced with functional octapeptide (Cys-Lys-His-Gly-d-Arg-d-Tyr-Lys-Phe, SS08) to build the mitochondria-targeted nanoparticles (PGA-Cu@SS08), and embedded within a hydrogel matrix to form a nanocomposite hydrogel, is explored. The nanoparticles show targeted localization within mitochondria, effectively scavenging reactive oxygen species and preserving mitochondrial function. The abundant phenolic hydroxyl groups present on the nanoparticle surface, along with the histidine residue of the SS08 peptide, endow these entities with the capacity to chelate iron. Through RNA sequencing analysis, it is discovered that PGA-Cu@SS08 activates the NRF2 signaling pathway, mitigating ferroptosis. It also reduces iron overload by inhibiting the autophagy of iron storage proteins. Additionally, the nanocomposite hydrogels exhibit excellent biocompatibility and biodegradability, along with enhanced mechanical properties that improve intervertebral disc (IVD) performance. PGA-Cu@SS08 is continuously released from these hydrogels, restoring IVD height and maintaining tissue hydration levels, thus facilitating future applications for alleviating IVDD.",
    "authors": [
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Zhenyu",
            "initials": "Z",
            "lastname": "Guo"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Xinzhou",
            "initials": "X",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Jing",
            "initials": "J",
            "lastname": "Sun"
        },
        {
            "affiliation": "Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200082, China.",
            "firstname": "QiZhu",
            "initials": "Q",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Linjie",
            "initials": "L",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Ouqiang",
            "initials": "O",
            "lastname": "Wu"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Yuxin",
            "initials": "Y",
            "lastname": "Jin"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Taidong",
            "initials": "T",
            "lastname": "Lyu"
        },
        {
            "affiliation": "Spine Unit, The Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham, B31 2AP, UK.",
            "firstname": "Jones",
            "initials": "J",
            "lastname": "Morgan"
        },
        {
            "affiliation": "The Minimally Invasive Brain and Spine Institute, Department of Neurosurgery, State University of New York Upstate medical university, 475 Irving Ave, #402, Syracuse, NY, 13210, USA.",
            "firstname": "Yan Michael",
            "initials": "YM",
            "lastname": "Li"
        },
        {
            "affiliation": "The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, China.",
            "firstname": "Hao",
            "initials": "H",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Yongcheng",
            "initials": "Y",
            "lastname": "Chen"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Xiuling",
            "initials": "X",
            "lastname": "You"
        },
        {
            "affiliation": "Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Yunlong",
            "initials": "Y",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, China.",
            "firstname": "Yu",
            "initials": "Y",
            "lastname": "Chen"
        },
        {
            "affiliation": "Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.\nCINBIO, University of Vigo, Campus University Lagoas Marcosende, Vigo, 36310, Spain.",
            "firstname": "Qiuping",
            "initials": "Q",
            "lastname": "Qian"
        },
        {
            "affiliation": "Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.",
            "firstname": "Aimin",
            "initials": "A",
            "lastname": "Wu"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025 Wiley\u2010VCH GmbH.",
    "doi": "10.1002/adhm.202403892",
    "journal": "Advanced healthcare materials",
    "keywords": [
        "ferroptosis",
        "intervertebral disc degeneration",
        "mitochondrial dysfunction",
        "mitochondrial target",
        "nanocomposite hydrogel"
    ],
    "methods": null,
    "publication_date": "2025-03-13",
    "pubmed_id": "40079053",
    "results": null,
    "title": "Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis.",
    "xml": "<Element 'PubmedArticle' at 0x788504b2f3d0>"
}