{
    "abstract": "\u2003Deep vein thrombosis (DVT) can lead to pulmonary embolism (PE), but the mechanisms responsible for this progression are unknown. Previously, we showed that inhibition of thrombin-mediated activation of factor (F) XIII promotes venous thrombus stability in a murine model.\n\u2003In this study, we investigate the consequence of attenuating fibrinolysis, using FXIII, \u03b1\n\u2003In vitro plasma clot lysis assay shows that EACA and \u03b1\n\u2003The change in thrombus size over time was significantly greater after EACA treatment, but not FXIII or \u03b1\n\u2003FXIII supplementation stabilized venous thrombi, even in the presence of anticoagulants, and did not alter thrombus size. Supplemental FXIII may be useful to stabilize DVT and be an alternative adjunctive treatment to minimize PE, even when anticoagulants are used.",
    "authors": [
        {
            "affiliation": "Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.",
            "firstname": "Shana A",
            "initials": "SA",
            "lastname": "Shaya"
        },
        {
            "affiliation": "Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.",
            "firstname": "Dhulfiha Muzafar",
            "initials": "DM",
            "lastname": "Gani"
        },
        {
            "affiliation": "Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.",
            "firstname": "Jeffrey I",
            "initials": "JI",
            "lastname": "Weitz"
        },
        {
            "affiliation": "Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.",
            "firstname": "Paul Y",
            "initials": "PY",
            "lastname": "Kim"
        },
        {
            "affiliation": "Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.\nDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.",
            "firstname": "Peter L",
            "initials": "PL",
            "lastname": "Gross"
        }
    ],
    "conclusions": "\u2003FXIII supplementation stabilized venous thrombi, even in the presence of anticoagulants, and did not alter thrombus size. Supplemental FXIII may be useful to stabilize DVT and be an alternative adjunctive treatment to minimize PE, even when anticoagulants are used.",
    "copyrights": "Georg Thieme Verlag KG Stuttgart \u00b7 New York.",
    "doi": "10.1055/s-0039-1685141",
    "journal": "Thrombosis and haemostasis",
    "keywords": [],
    "methods": null,
    "publication_date": "2019-04-21",
    "pubmed_id": "31005064",
    "results": "\u2003The change in thrombus size over time was significantly greater after EACA treatment, but not FXIII or \u03b1",
    "title": "Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi.",
    "xml": "<Element 'PubmedArticle' at 0x788504263d30>"
}