{
    "abstract": "Although aptamers have shown excellent target specificity in preclinical and clinical studies either by themselves or as aptamer-drug conjugates, their in vivo tissue pharmacokinetic (PK) analysis is still problematic. We aimed to examine the utility of image-based positron emission tomography (PET) to evaluate in vivo tissue PK, target specificity, and applicability of oligonucleotides. For this, fluorine-18-labeled aptamers with erb-b2 receptor tyrosine kinase 2 (ERBB2)-specific binding were synthesized by base-pair hybridization using a complementary oligonucleotide platform. To investigate the PKs and properties of in vivo tissue, usefulness of in vivo PET imaging in the development of an oligonucleotide-based drug as an assessment tool was evaluated in normal and tumor xenografted mice. ERBB2-cODN-idT-APs-[",
    "authors": [
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Sun Mi",
            "initials": "SM",
            "lastname": "Park"
        },
        {
            "affiliation": "Research and Development Center, UMUST R&D Corporation, Seoul, South Korea.",
            "firstname": "Suji",
            "initials": "S",
            "lastname": "Baek"
        },
        {
            "affiliation": "Research and Development Center, INTEROligo Corporation, Anyang, South Korea.",
            "firstname": "Jung Hwan",
            "initials": "JH",
            "lastname": "Lee"
        },
        {
            "affiliation": "Division of RI Applications, Korea Institute Radiological and Medical Sciences, Seoul, South Korea.",
            "firstname": "Sang-Keun",
            "initials": "SK",
            "lastname": "Woo"
        },
        {
            "affiliation": "Division of RI Applications, Korea Institute Radiological and Medical Sciences, Seoul, South Korea.",
            "firstname": "Tae Sup",
            "initials": "TS",
            "lastname": "Lee"
        },
        {
            "affiliation": "Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.",
            "firstname": "Hyun Soo",
            "initials": "HS",
            "lastname": "Park"
        },
        {
            "affiliation": "Research and Development Center, INTEROligo Corporation, Anyang, South Korea.",
            "firstname": "Jongook",
            "initials": "J",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Yeon-Koo",
            "initials": "YK",
            "lastname": "Kang"
        },
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Seo Young",
            "initials": "SY",
            "lastname": "Kang"
        },
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Min Young",
            "initials": "MY",
            "lastname": "Yoo"
        },
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Hai-Jeon",
            "initials": "HJ",
            "lastname": "Yoon"
        },
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Bom Sahn",
            "initials": "BS",
            "lastname": "Kim"
        },
        {
            "affiliation": "Research and Development Center, UMUST R&D Corporation, Seoul, South Korea.",
            "firstname": "Kang Pa",
            "initials": "KP",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.",
            "firstname": "Byung Seok",
            "initials": "BS",
            "lastname": "Moon"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.",
    "doi": "10.1111/cts.13522",
    "journal": "Clinical and translational science",
    "keywords": [],
    "methods": null,
    "publication_date": "2023-04-12",
    "pubmed_id": "37038354\n30125604\n29186809\n29136589\n28054983\n27807347\n20055704\n8743326\n18282139\n30128033\n30706991\n30321620\n11884626\n16460794\n1523413\n32455729\n22695940\n18298126\n12937873\n33287349\n34574002\n34085761\n35626428\n23991644\n30344278\n21658962\n10549807\n33625181\n14960659\n24675379\n10767595\n15219279\n10995205\n18292870\n25473848\n27258484\n32211931\n29777007\n25093706\n17279100\n23142634\n17172400\n26831421",
    "results": null,
    "title": "In vivo tissue pharmacokinetics of ERBB2-specific binding oligonucleotide-based drugs by PET imaging.",
    "xml": "<Element 'PubmedArticle' at 0x788504292610>"
}