{
    "abstract": "To investigate prematurity rate in women aged \u2265 45 carrying a singleton pregnancy. Other maternal and neonatal outcomes are also described.\nRetrospective cohort study.\nWomen delivering a singleton pregnancy at a single tertiary medical center.\nThe study included all women aged 45 years and over who delivered at 20 weeks gestation or beyond over a 9-year period from May 2000 to May 2009.\nWomen aged 45 years and over were identified. The study group was compared to a control group of women <40 years with singleton pregnancies conceived by in vitro fertilization (IVF) who delivered during the same time period.\nMaternal complications during pregnancy and neonatal outcome.\nDuring the study period 278 women \u2265 45 years delivered a singleton pregnancy. The control group included 304 women. The rate of delivery before 37 weeks as well as before 32 weeks were very high in our study group (18.7 vs. 10.9%, p = 0.009 and 5.4 vs. 2.0%, p = 0.04, respectively). In multivariate analysis, older maternal age was not independently related to prematurity. Chronic hypertension (HTN) was found to be a major risk factor associated with prematurity in advanced maternal age.\nWomen \u2265 45-years-old with a singleton pregnancy carry a higher risk of maternal and perinatal complications. Preterm birth is a significant complication in this age group and is associated with preexisting chronic HTN.",
    "authors": [
        {
            "affiliation": "Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.",
            "firstname": "Ido",
            "initials": "I",
            "lastname": "Laskov"
        },
        {
            "affiliation": null,
            "firstname": "Roee",
            "initials": "R",
            "lastname": "Birnbaum"
        },
        {
            "affiliation": null,
            "firstname": "Sharon",
            "initials": "S",
            "lastname": "Maslovitz"
        },
        {
            "affiliation": null,
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Kupferminc"
        },
        {
            "affiliation": null,
            "firstname": "Joseph",
            "initials": "J",
            "lastname": "Lessing"
        },
        {
            "affiliation": null,
            "firstname": "Ariel",
            "initials": "A",
            "lastname": "Many"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3109/14767058.2012.684108",
    "journal": "The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians",
    "keywords": [],
    "methods": null,
    "publication_date": "2012-04-25",
    "pubmed_id": "22524796",
    "results": "During the study period 278 women \u2265 45 years delivered a singleton pregnancy. The control group included 304 women. The rate of delivery before 37 weeks as well as before 32 weeks were very high in our study group (18.7 vs. 10.9%, p = 0.009 and 5.4 vs. 2.0%, p = 0.04, respectively). In multivariate analysis, older maternal age was not independently related to prematurity. Chronic hypertension (HTN) was found to be a major risk factor associated with prematurity in advanced maternal age.",
    "title": "Outcome of singleton pregnancy in women \u2265 45 years old: a retrospective cohort study.",
    "xml": "<Element 'PubmedArticle' at 0x788506c17100>"
}