{
    "abstract": "Programmed cell death-ligand 1 (PD-L1)/PD-1 axis is crucial for maintenance of immune homeostasis and its impairment partially accounts for the pathogenesis of inflammatory diseases. Hence, augmenting PD-L1/PD-1 signals represents a novel strategy to prevent destructive inflammation and induce immune tolerance. Recently, we developed a new cargo by conjugating the ectodomain of PD-L1 with pHLIP, a low pH-responding and membrane-inserting peptide, and demonstrated its potent immune-suppressive activity under weakly acidic (pH6.1) conditions in vitro. Herein, we further showed that PD-L1-pHLIP (termed as PD-L1-pHLIP",
    "authors": [
        {
            "affiliation": "Research Center of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, 010058, Inner Mongolia, China.\nInstitute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Hang",
            "initials": "H",
            "lastname": "Zheng"
        },
        {
            "affiliation": "Research Center of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, 010058, Inner Mongolia, China.\nInstitute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Mianjing",
            "initials": "M",
            "lastname": "Wang"
        },
        {
            "affiliation": "Research Center of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, 010058, Inner Mongolia, China.\nInstitute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Junjuan",
            "initials": "J",
            "lastname": "Feng"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Yuting",
            "initials": "Y",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Haiyan",
            "initials": "H",
            "lastname": "Wu"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Min",
            "initials": "M",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "He",
            "initials": "H",
            "lastname": "Xiao"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Chunxia",
            "initials": "C",
            "lastname": "Qiao"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Jing",
            "initials": "J",
            "lastname": "Wang"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Longlong",
            "initials": "L",
            "lastname": "Luo"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Xinying",
            "initials": "X",
            "lastname": "Li"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China.",
            "firstname": "Jiannan",
            "initials": "J",
            "lastname": "Feng"
        },
        {
            "affiliation": "Research Center of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, 010058, Inner Mongolia, China. zhengyq688@163.com.",
            "firstname": "Yuanqiang",
            "initials": "Y",
            "lastname": "Zheng"
        },
        {
            "affiliation": "Department of Hematology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100071, China. yk091023@163.com.",
            "firstname": "Yi",
            "initials": "Y",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Thoracic surgery, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100071, China. shengdongsheng1978@163.com.",
            "firstname": "Dongsheng",
            "initials": "D",
            "lastname": "Sheng"
        },
        {
            "affiliation": "Institute of Pharmacology and Toxicology, Beijing, 100850, China. jyk62033@163.com.",
            "firstname": "Guojiang",
            "initials": "G",
            "lastname": "Chen"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2025. The Author(s).",
    "doi": "10.1038/s41598-025-98135-4",
    "journal": "Scientific reports",
    "keywords": [
        "Acidity",
        "Immunosuppression",
        "PD-L1",
        "T cell",
        "pHLIPva"
    ],
    "methods": null,
    "publication_date": "2025-04-19",
    "pubmed_id": "40251234\n15771580\n29260623\n31636634\n27660198\n34491911\n34272285\n9398245\n25409146\n31474761\n16608910\n32196345\n35003115\n19931353\n23721379\n25650762\n18198346\n28768162\n21308906\n23853124\n32839570\n31819164\n28438340\n31792360\n20160113\n36595702\n31689432\n30503536\n25692583\n29742404\n30954213\n31422821\n33423684\n33088640",
    "results": null,
    "title": "Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1.",
    "xml": "<Element 'PubmedArticle' at 0x788504ae4400>"
}