{
    "abstract": "Patients with single ventricle anatomy palliated with Fontan operation are at risk for thromboembolism, arrhythmia, and heart failure rendering pregnancy high risk or even contraindicated. Infertility and high rates of first trimester miscarriage are not uncommon. In vitro fertilization (IVF) with or without gestational surrogacy can be an option, but poses risks during ovarian stimulation, oocyte retrieval, and the post-procedural period. We present six cases of women with complex congenital heart disease status post Fontan operation who underwent successful IVF.\nCase series from a single-center tertiary care setting.\nIndications for referral were cardiac or fertility concerns for pregnancy of the congenital cardiologist. One woman had mild volume overload after oocyte retrieval requiring furosemide and one experienced post-operative colitis. There were no thrombotic complications.\nA multidisciplinary team-based approach can result in successful oocyte retrieval and IVF in women with complex congenital heart disease and Fontan physiology.",
    "authors": [
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Yuli.Kim@pennmedicine.upenn.edu.\nDivision of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Yuli.Kim@pennmedicine.upenn.edu.\nPhiladelphia Adult Congenital Heart Center, Penn Medicine & Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, PCAM 2nd Floor E. Pavilion, Philadelphia, PA, 19104, USA. Yuli.Kim@pennmedicine.upenn.edu.",
            "firstname": "Yuli Y",
            "initials": "YY",
            "lastname": "Kim"
        },
        {
            "affiliation": "Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
            "firstname": "Lisa D",
            "initials": "LD",
            "lastname": "Levine"
        },
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.\nPhiladelphia Adult Congenital Heart Center, Penn Medicine & Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, PCAM 2nd Floor E. Pavilion, Philadelphia, PA, 19104, USA.",
            "firstname": "Sara L",
            "initials": "SL",
            "lastname": "Partington"
        },
        {
            "affiliation": "Department of Anesthesia and Critical Care, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
            "firstname": "Prakash A",
            "initials": "PA",
            "lastname": "Patel"
        },
        {
            "affiliation": "Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.\nPhiladelphia Adult Congenital Heart Center, Penn Medicine & Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, PCAM 2nd Floor E. Pavilion, Philadelphia, PA, 19104, USA.",
            "firstname": "Emily",
            "initials": "E",
            "lastname": "Ruckdeschel"
        },
        {
            "affiliation": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
            "firstname": "Suneeta",
            "initials": "S",
            "lastname": "Senapati"
        },
        {
            "affiliation": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.",
            "firstname": "Clarisa R",
            "initials": "CR",
            "lastname": "Gracia"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1007/s10815-020-01969-2\n10.1161/CIRCULATIONAHA.110.946343\n10.1016/j.ijcard.2015.03.344\n10.1111/chd.12291\n10.1136/heartjnl-2015-308788\n10.1016/j.ijcard.2016.01.180\n10.1161/CIRCOUTCOMES.117.004575\n10.1016/0735-1097(96)00234-3\n10.1136/hrt.2005.085407\n10.1586/erc.11.158\n10.1016/0140-6736(90)92568-3\n10.1007/s00246-010-9808-4\n10.1136/hrt.2006.095240\n10.1016/j.fertnstert.2016.08.048",
    "journal": "Journal of assisted reproduction and genetics",
    "keywords": [
        "Case report",
        "Complex congenital heart disease",
        "In vitro fertilization",
        "Multidisciplinary"
    ],
    "methods": null,
    "publication_date": "2020-10-12",
    "pubmed_id": "33040295\n21098444\n25828319\n26239864\n26786817\n26836494\n29752389\n8772769\n16449503\n22103874\n1977979\n20967441\n16973809\n27678032",
    "results": "Indications for referral were cardiac or fertility concerns for pregnancy of the congenital cardiologist. One woman had mild volume overload after oocyte retrieval requiring furosemide and one experienced post-operative colitis. There were no thrombotic complications.",
    "title": "Successful in vitro fertilization in women with Fontan physiology.",
    "xml": "<Element 'PubmedArticle' at 0x78850414d3a0>"
}