{
    "abstract": "Antifibrinolytics have gained increasing attention in minimizing blood loss and mitigating the risks associated with massive transfusions, including infection and coagulopathy in pediatric patients undergoing spine surgery. Nevertheless, the selection of optimal agent is still a matter of debate. We aim to review the utility of these agents and compare the efficacy of antifibrinolytics in pediatric and adolescent spine surgeries. A comprehensive search was performed in Scopus, Web of Science, and MEDLINE databases for relevant works. Studies providing quantitative data on predefined outcomes were included. Primary outcome was perioperative bleeding between the groups. Secondary outcomes included transfusion volume, rate of complications, and operation time. Twenty-eight studies were included in the meta-analysis incorporating 2553 patients. The use of Tranexamic acid (RoM: 0.71, 95%CI: [0.62-0.81], p\u2009<\u20090.001, I",
    "authors": [
        {
            "affiliation": "School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. sepehraghajanian2@gmail.com.\nNeuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran. sepehraghajanian2@gmail.com.",
            "firstname": "Sepehr",
            "initials": "S",
            "lastname": "Aghajanian"
        },
        {
            "affiliation": "School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.",
            "firstname": "Fateme",
            "initials": "F",
            "lastname": "Mohammadifard"
        },
        {
            "affiliation": "Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.\nHeadache Research Center, Neurology Department, Tehran University of Medical Sciences, Tehran, Iran.",
            "firstname": "Omid",
            "initials": "O",
            "lastname": "Kohandel Gargari"
        },
        {
            "affiliation": "Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Gilan, Iran.",
            "firstname": "Arvin",
            "initials": "A",
            "lastname": "Naeimi"
        },
        {
            "affiliation": "Department of Health & Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.",
            "firstname": "Ayad",
            "initials": "A",
            "lastname": "Bahadorimonfared"
        },
        {
            "affiliation": "Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. aladine.elsamadicy@yale.edu.",
            "firstname": "Aladine A",
            "initials": "AA",
            "lastname": "Elsamadicy"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
    "doi": "10.1007/s10143-024-02424-x",
    "journal": "Neurosurgical review",
    "keywords": [
        "Antifibrinolytic",
        "Aprotinin",
        "Epsilon-aminocaproic acid",
        "Neurological surgery",
        "Perioperative care",
        "Spine",
        "Tranexamic acid"
    ],
    "methods": null,
    "publication_date": "2024-04-22",
    "pubmed_id": "38644447\n25681582\n15486006\n15197630\n26382761\n23424632\n27671279\n9673304\n24278471\n37390775\n18820953\n12960633\n24432083\n11429344\n22872217\n15791100\n17873823\n16138073\n18794767\n24875032\n22772572\n34654764\n25813212\n31732001\n14595168\n11413428\n14752343\n30516625\n27927417\n34262824\n22037532\n33826563\n21575004\n19301800\n30739188\n21412876\n30807356\n9416723\n19305284\n29120963\n33844193\n33049411",
    "results": null,
    "title": "Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis.",
    "xml": "<Element 'PubmedArticle' at 0x788505734ea0>"
}