{
    "abstract": "A lack of serotonin (also known as 5-hydroxytryptamine, 5-HT) in the brain due to deficiency of the rate-limiting enzyme in 5-HT synthesis, tryptophan hydroxylase 2 (TPH2), was recently reported to result in impaired maternal affiliation across species, including mice, rats, and monkeys. In rodents, this was reflected in a lack of preference for maternal odors and reduced levels of isolation-induced ultrasonic vocalizations (USV), possibly contributing to a severe growth retardation phenotype.\nHere, we tested whether growth retardation, maternal affiliation deficits, and/or impairments in socio-affective communication caused by Tph2 deficiency can be rescued through early social enrichment in rats. To this aim, we compared male and female Tph2\nOur results show that Tph2 deficiency causes severe growth retardation, together with moderate impairments in somatosensory reflexes and thermoregulatory capabilities, partially aggravated by CN. Tph2 deficiency further led to deficits in socio-affective communication, as evidenced by reduced emission of isolation-induced USV, associated with changes in acoustic features, clustering of subtypes, and temporal organization. Although CN did not rescue the impairments in socio-affective communication, CN ameliorated the maternal affiliation deficit caused by Tph2 deficiency in the homing test. To close the communicative loop between mother and pup, we assessed maternal preference and showed that mothers display a preference for Tph2\nTogether, this indicates that CN aggravates growth retardation despite ameliorating maternal affiliation deficits in Tph2-deficient rat pups, possibly due to reduced and acoustically altered isolation-induced USV, hindering efficient socio-affective communication between mother and pup.",
    "authors": [
        {
            "affiliation": "Faculty of Psychology, Experimental and Biological Psychology, Philipps-Universit\u00e4t Marburg, Behavioral Neuroscience, 35032, Marburg, Germany.\nPhilipps-Universit\u00e4t Marburg, Center for Mind, Brain, and Behavior (CMBB), 35032, Marburg, Germany.",
            "firstname": "Tianhua",
            "initials": "T",
            "lastname": "Wang"
        },
        {
            "affiliation": "Department of Cognitive Neuroscience, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, The Netherlands.",
            "firstname": "Judith R",
            "initials": "JR",
            "lastname": "Homberg"
        },
        {
            "affiliation": "Molecular Biology of Peptide Hormones, Max-Delbr\u00fcck-Centrum F\u00fcr Molekulare Medizin (MDC), 13125, Berlin, Germany.",
            "firstname": "Laura",
            "initials": "L",
            "lastname": "Boreggio"
        },
        {
            "affiliation": "Radboud University, Donders Institute for Brain, Cognition, and Behaviour, 6525 AJ, Nijmegen, The Netherlands.",
            "firstname": "Marta C F",
            "initials": "MCF",
            "lastname": "Samina"
        },
        {
            "affiliation": "Department of Cognitive Neuroscience, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, The Netherlands.",
            "firstname": "Rog\u00e9rio C R",
            "initials": "RCR",
            "lastname": "Castro"
        },
        {
            "affiliation": "Radboud University, Donders Institute for Brain, Cognition, and Behaviour, 6525 AJ, Nijmegen, The Netherlands.",
            "firstname": "Sharon M",
            "initials": "SM",
            "lastname": "Kolk"
        },
        {
            "affiliation": "Molecular Biology of Peptide Hormones, Max-Delbr\u00fcck-Centrum F\u00fcr Molekulare Medizin (MDC), 13125, Berlin, Germany.\nGerman Center for Cardiovascular Research (DZHK), partner site Berlin, 10785, Berlin, Germany.",
            "firstname": "Natalia",
            "initials": "N",
            "lastname": "Alenina"
        },
        {
            "affiliation": "Molecular Biology of Peptide Hormones, Max-Delbr\u00fcck-Centrum F\u00fcr Molekulare Medizin (MDC), 13125, Berlin, Germany.\nGerman Center for Cardiovascular Research (DZHK), partner site Berlin, 10785, Berlin, Germany.\nCharit\u00e9 University Medicine Berlin, 10117, Berlin, Germany.\nInstitute for Biology, University of L\u00fcbeck, 23562, L\u00fcbeck, Germany.",
            "firstname": "Michael",
            "initials": "M",
            "lastname": "Bader"
        },
        {
            "affiliation": "Department of Pharmacological Sciences and Department of Neuroscience, Mount Sinai, Icahn School of Medicine, Friedman Brain Institute, New York, 10029, USA.",
            "firstname": "Jinye",
            "initials": "J",
            "lastname": "Dai"
        },
        {
            "affiliation": "Faculty of Psychology, Experimental and Biological Psychology, Philipps-Universit\u00e4t Marburg, Behavioral Neuroscience, 35032, Marburg, Germany. markus.wohr@kuleuven.be.\nPhilipps-Universit\u00e4t Marburg, Center for Mind, Brain, and Behavior (CMBB), 35032, Marburg, Germany. markus.wohr@kuleuven.be.\nFaculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, KU Leuven, Tiensestraat 102 - Bus 3714, 3000, Louvain, Belgium. markus.wohr@kuleuven.be.\nKU Leuven, Leuven Brain Institute, 3000, Louvain, Belgium. markus.wohr@kuleuven.be.",
            "firstname": "Markus",
            "initials": "M",
            "lastname": "W\u00f6hr"
        }
    ],
    "conclusions": "Together, this indicates that CN aggravates growth retardation despite ameliorating maternal affiliation deficits in Tph2-deficient rat pups, possibly due to reduced and acoustically altered isolation-induced USV, hindering efficient socio-affective communication between mother and pup.",
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s13229-024-00629-x",
    "journal": "Molecular autism",
    "keywords": [
        "Autism",
        "Neurodevelopmental disorders",
        "Serotonin",
        "Social behavior",
        "Tryptophan hydroxylase 2",
        "Ultrasonic vocalizations"
    ],
    "methods": null,
    "publication_date": "2024-11-30",
    "pubmed_id": "39614401\n38889770\n19520831\n4664924\n36798444\n25706994\n25089765\n22443164\n25077934\n25808003\n11803447\n7755521\n21237232\n22910688\n23352923\n23375168\n19576924\n20171244\n30610191\n17624451\n3808021\n23994547\n34173729\n18940203\n14618156\n25716307\n19515648\n2976898\n6322290\n32824000\n24602541\n17928040\n16359723\n8276064\n10086229\n26869713\n23139830\n30718564\n10818252\n1675993\n8029267\n25435080\n28866660\n38052167\n21441904\n36868221\n30977041\n19762157\n30087403\n25446220\n36197033\n30256726\n25901271\n22832966\n26577932\n24769172\n33727585\n23336056\n9884114\n17406675\n31078489\n36889803\n20540967\n18923670\n5814184\n32547368\n29797318\n5464098\n4429513\n17356576\n26419918\n28972592\n31068767\n12511643\n1973197\n2137699\n1771219\n24726578\n25852455\n18712592\n35538503\n21695253\n18410171\n23576070\n26221830\n23716677\n25503615",
    "results": "Our results show that Tph2 deficiency causes severe growth retardation, together with moderate impairments in somatosensory reflexes and thermoregulatory capabilities, partially aggravated by CN. Tph2 deficiency further led to deficits in socio-affective communication, as evidenced by reduced emission of isolation-induced USV, associated with changes in acoustic features, clustering of subtypes, and temporal organization. Although CN did not rescue the impairments in socio-affective communication, CN ameliorated the maternal affiliation deficit caused by Tph2 deficiency in the homing test. To close the communicative loop between mother and pup, we assessed maternal preference and showed that mothers display a preference for Tph2",
    "title": "Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits.",
    "xml": "<Element 'PubmedArticle' at 0x7885048fa980>"
}