{
    "abstract": "COVID-19 is a serious virus that can have a lot of effects, one of which is a secondary bacterial infection that can be more life-threatening and even lethal than the initial viral infection. Hence a fast and sensitive HPLC/UV method was developed and validated for the first estimation of a binary mixture of molnupiravir (MOL) and ertapenem (ERT) as a co-administrated medicine for the management of COVID-19 in pharmaceutical dosage forms, and human plasma samples. The drug combination was separated within 5\u00a0min via RP-ODS column using isocratic elution with a mobile phase of 0.05\u00a0M phosphate buffer (pH 3.5): acetonitrile with a 76: 24% ratio v/v. The presented method provided a linear response ranging from 0.03 to 17.0 and 0.05-20\u00a0\u00b5g mL",
    "authors": [
        {
            "affiliation": "Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assuit branch, 71524, Assuit, Egypt. khaledafify@azhar.edu.eg.",
            "firstname": "Khaled K",
            "initials": "KK",
            "lastname": "Afify"
        },
        {
            "affiliation": "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia.",
            "firstname": "Ramadan",
            "initials": "R",
            "lastname": "Ali"
        },
        {
            "affiliation": "Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.",
            "firstname": "Mohammad A",
            "initials": "MA",
            "lastname": "El-Dosoky"
        },
        {
            "affiliation": "Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.",
            "firstname": "Mohamed Wafaa I",
            "initials": "MWI",
            "lastname": "Nassar"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023. Springer Nature Switzerland AG.",
    "doi": "10.1186/s13065-023-01024-y\n10.1056/NEJMoa2001316\n10.1039/D2RA02241A\n10.1016/S0140-6736(20)30183-5\n10.1056/EVIDoa2100043\n10.1016/S2666-5247(20)30172-5\n10.1016/S0140-6736(21)02796-3\n10.1016/j.cmi.2020.09.055\n10.2165/00003495-200767070-00006\n10.1111/ijcp.14230\n10.30574/wjarr.2022.15.1.0720\n10.1016/j.jpba.2022.114693\n10.1016/j.jchromb.2022.123363\n10.1093/chromsci/48.8.624\n10.1002/bmc.2829\n10.1039/D0RA10466C\n10.1016/S1570-0232(02)00377-X\n10.55705/cmbr.2023.375093.1087\n10.1016/j.microc.2022.108262\n10.1002/jssc.202200178\n10.1016/j.jelechem.2022.116579\n10.1016/j.microc.2020.105752\n10.1016/j.saa.2008.12.025\n10.1007/s11696-019-00824-8\n10.1016/j.saa.2010.06.019\n10.1016/j.saa.2022.121911\n10.1016/j.saa.2021.120077\n10.1002/bio.4223\n10.4155/bio.13.298",
    "journal": "BMC chemistry",
    "keywords": [
        "COVID-19",
        "ERT",
        "HPLC-UV",
        "Human plasma",
        "MOL"
    ],
    "methods": null,
    "publication_date": "2023-09-22",
    "pubmed_id": "37735684\n31995857\n31978945\n35754906\n31986264\n38319179\n33521734\n35279232\n34271264\n33248926\n17488146\n18076336\n33864405\n35462678\n35276385\n35810537\n27591671\n20819290\n16488198\n23065850\n35747078\n12361748\n35583051\n19167266\n20634123\n36174404\n34175763\n35274447\n28700141\n24256335",
    "results": null,
    "title": "HPLC/UV approach method for the first simultaneous estimation of molnupiravir and ertapenem as a binary mixture in human plasma and dosage form as a regimen for COVID-19 treatments.",
    "xml": "<Element 'PubmedArticle' at 0x788503044310>"
}