{
    "abstract": "Management of the contralateral cN0 neck in well-lateralized oral tongue squamous cell carcinoma (OTSCC) is controversial. Depth of invasion (DOI) is a strong predictor of ipsilateral nodal metastases. This study examines if DOI can predict contralateral neck disease (CND).\nA retrospective analysis was performed on patients treated with primary surgery for lateralized OTSCC at a single tertiary care academic institution from 2014 to 2021. Multivariable analysis was performed to assess the relationship between DOI and CND.\n155 patients were included. 101 (65.2%) patients had T1/T2 disease, while 54 (34.8%) had T3/T4 disease. 22 (14.2%) patients had CND. Mean DOI of patients with CND and without CND was 21.0\u00a0mm and 9.8\u00a0mm (p\u00a0<\u00a00.001), respectively. Univariable regression models showed higher DOI was associated with increased risk of CND overall (OR = 1.11, 95% CI: 1.06, 1.17, p\u00a0<\u00a00.001), in patients with T1 disease (OR = 1.38, 95% CI: 1.11, 2.20, p\u00a0=\u00a00.038), and in patients with cN0 disease (OR = 1.09, 95% CI: 1.01, 1.17, p\u00a0=\u00a00.028). Multivariable regression model confirmed higher DOI was associated with increased risk of CND (OR = 1.09, 95% CI: 1.04, 1.16, p\u00a0=\u00a00.001). A DOI of 6\u00a0mm was identified as a potential threshold for increased risk of CND.\nDOI was identified as a predictive factor for CND in OTSCC. At the time of ipsilateral neck dissection, a DOI \u2265 6\u00a0mm may represent a threshold associated with an increased risk of CND, indicating that contralateral neck management could be considered.",
    "authors": [
        {
            "affiliation": "Department of Otolaryngology, University of Florida, Gainesville FL, USA.",
            "firstname": "Logesvar",
            "initials": "L",
            "lastname": "Balaguru"
        },
        {
            "affiliation": "Department of Otolaryngology, University of Florida, Gainesville FL, USA.",
            "firstname": "Cristina",
            "initials": "C",
            "lastname": "Benites"
        },
        {
            "affiliation": "Department of Otolaryngology, University of Florida, Gainesville FL, USA.",
            "firstname": "Krishna S",
            "initials": "KS",
            "lastname": "Hanubal"
        },
        {
            "affiliation": "Division of Quantitative Sciences, University of Florida Health Cancer Center, Gainesville FL, USA.",
            "firstname": "Gonghao",
            "initials": "G",
            "lastname": "Liu"
        },
        {
            "affiliation": "Division of Quantitative Sciences, University of Florida Health Cancer Center, Gainesville FL, USA; Department of Biostatistics, University of Florida, Gainesville FL, USA.",
            "firstname": "Ji-Hyun",
            "initials": "JH",
            "lastname": "Lee"
        },
        {
            "affiliation": "Department of Otolaryngology, University of Florida, Gainesville FL, USA.",
            "firstname": "Dustin",
            "initials": "D",
            "lastname": "Conrad"
        },
        {
            "affiliation": "College of Medicine, University of Florida, Gainesville FL, USA.",
            "firstname": "Colyn",
            "initials": "C",
            "lastname": "White"
        },
        {
            "affiliation": "College of Medicine, University of Florida, Gainesville FL, USA.",
            "firstname": "Arunima",
            "initials": "A",
            "lastname": "Vijay"
        },
        {
            "affiliation": "Department of Otolaryngology, University of Florida, Gainesville FL, USA; University of Florida Health Cancer Center, Gainesville FL, USA. Electronic address: peter.dziegielewski@ent.ufl.edu.",
            "firstname": "Peter T",
            "initials": "PT",
            "lastname": "Dziegielewski"
        }
    ],
    "conclusions": "DOI was identified as a predictive factor for CND in OTSCC. At the time of ipsilateral neck dissection, a DOI \u2265 6\u00a0mm may represent a threshold associated with an increased risk of CND, indicating that contralateral neck management could be considered.",
    "copyrights": "Copyright \u00a9 2025 Elsevier Ltd. All rights reserved.",
    "doi": "10.1016/j.oraloncology.2025.107334",
    "journal": "Oral oncology",
    "keywords": [
        "Depth of Invasion",
        "Neck Dissection",
        "Oral Cancer",
        "Tongue Cancer"
    ],
    "methods": null,
    "publication_date": "2025-04-28",
    "pubmed_id": "40288076",
    "results": "155 patients were included. 101 (65.2%) patients had T1/T2 disease, while 54 (34.8%) had T3/T4 disease. 22 (14.2%) patients had CND. Mean DOI of patients with CND and without CND was 21.0\u00a0mm and 9.8\u00a0mm (p\u00a0<\u00a00.001), respectively. Univariable regression models showed higher DOI was associated with increased risk of CND overall (OR = 1.11, 95% CI: 1.06, 1.17, p\u00a0<\u00a00.001), in patients with T1 disease (OR = 1.38, 95% CI: 1.11, 2.20, p\u00a0=\u00a00.038), and in patients with cN0 disease (OR = 1.09, 95% CI: 1.01, 1.17, p\u00a0=\u00a00.028). Multivariable regression model confirmed higher DOI was associated with increased risk of CND (OR = 1.09, 95% CI: 1.04, 1.16, p\u00a0=\u00a00.001). A DOI of 6\u00a0mm was identified as a potential threshold for increased risk of CND.",
    "title": "The predictive value of tumor depth of invasion for contralateral neck disease in tongue cancer.",
    "xml": "<Element 'PubmedArticle' at 0x788502ca2e30>"
}