{
    "abstract": "Recent studies have shown that essential oils (EOs) extracted from medicinal and aromatic plants have herbicidal and/or insecticidal properties, helping to mitigate the toxicity experienced by living organisms exposed to pesticides. Moreover, the primary compounds isolated from these EOs also have the potential to reduce pesticide-induced damage. The present work aimed to evaluate the protective effects of Thymus numidicus (TNEO) and Lavandula stoechas (LSEO) against Deltamethrin-induced toxicity in female rabbits. The results obtained by GC/MS analysis showed that monoterpenes and oxygenated monoterpenes were the main components of the EOs extracted from the aerial parts of Thymus numidicus and Lavandula stoechas. The use of the pesticide Deltamethrin caused significant damage to the liver and kidneys (p < 0.05), together with blood disorders, signs of restlessness and tremors. However, females treated with TNEO showed better tolerance than the group treated with LSEO. The combination of both oils showed more pronounced protective effects. This suggests a potential synergistic effect in reducing deltamethrin-induced toxicity.",
    "authors": [
        {
            "affiliation": "Natural resources laboratory, Mouloud Mammeri University of Tizi Ouzou, 15000, Algeria. Electronic address: ouardia.chaouchi@fs.ummto.dz.",
            "firstname": "Ouardia",
            "initials": "O",
            "lastname": "Chaouchi"
        },
        {
            "affiliation": "Natural resources laboratory, Mouloud Mammeri University of Tizi Ouzou, 15000, Algeria.",
            "firstname": "Farida",
            "initials": "F",
            "lastname": "Fernane"
        },
        {
            "affiliation": "Natural resources laboratory, Mouloud Mammeri University of Tizi Ouzou, 15000, Algeria.",
            "firstname": "Nacira Daoudi",
            "initials": "ND",
            "lastname": "Zerrouki"
        },
        {
            "affiliation": "Natural resources laboratory, Mouloud Mammeri University of Tizi Ouzou, 15000, Algeria.",
            "firstname": "Hakima Ait",
            "initials": "HA",
            "lastname": "Issad"
        },
        {
            "affiliation": "Establishment in Cardiac Surgery Yacef Omar Draa Ben Khedda Tizi Ouzou, Algeria.",
            "firstname": "Thinhinane",
            "initials": "T",
            "lastname": "Chaouchi"
        },
        {
            "affiliation": "Laboratory of Natural Bioresources, Department of Biology, Faculty of Natural and Life Sciences,University Hassiba BEN BOUALI of Chlef, 02000, Algeria.",
            "firstname": "Azdinia",
            "initials": "A",
            "lastname": "Zidane"
        },
        {
            "affiliation": "LABAB Laboratory, Faculty of Biological and Agronomic Sciences, Mouloud Mammeri University of Tizi-Ouzou,15000, Algeria.",
            "firstname": "Karim",
            "initials": "K",
            "lastname": "Houali"
        }
    ],
    "conclusions": null,
    "copyrights": "Copyright \u00a9 2025. Published by Elsevier Ltd.",
    "doi": "10.1016/j.toxicon.2025.108232",
    "journal": "Toxicon : official journal of the International Society on Toxinology",
    "keywords": [
        "Deltamethrin",
        "Essential oil",
        "Lavandula stoechas",
        "Thymus numidicus",
        "Toxicity"
    ],
    "methods": null,
    "publication_date": "2025-01-11",
    "pubmed_id": "39793627",
    "results": null,
    "title": "Protective effects of Lavandula stoechas and Thymus numidicus essential oils against deltamethrin-induced hematological and biochemical toxicity in female rabbits.",
    "xml": "<Element 'PubmedArticle' at 0x788501e275b0>"
}