{
    "abstract": "To evaluate the effect of age on the association between maternal body mass index (BMI) and cumulative live birth rates (CLBRs) following in vitro fertilization treatment.\nWe retrospectively analyzed the data of 26\u2009567 women undergoing in vitro fertilization/intracytoplasmic sperm injection from 2016 to 2019. We conducted multivariate regression analysis of the association between CLBRs and maternal BMI and age category.\nA total of 16\u2009626 (62.58%) patients achieved a live birth. Women with obesity had significantly decreased CLBRs compared with women who had normal weight (odds ratio [OR] 0.73 [95% confidence interval (CI), 0.66-0.80]). The significant interaction between age and BMI suggested that the impact of BMI on CLBRs was moderated by women's age (P interaction <0.001). The association between obesity and CLBRs was inverse among women aged <30\u2009years (OR, 0.63 [95% CI, 0.54-0.73]), 30 to 34\u2009years (OR, 0.79 [95% CI, 0.67-0.93]), and 35 to 37\u2009years (OR, 0.71 [95% CI, 0.52-0.98]); however, decreases in CLBRs with obesity were not observed in women aged 38 to 40\u2009years (OR, 1.17 [95% CI, 0.70-1.94]) and\u2009\u2265\u200941\u2009years (OR, 1.25 [95% CI, 0.53-2.96]).\nMaternal obesity was significantly associated with a lower likelihood of having a live birth, but the risk differed according to women's age. A higher BMI might have a less-pronounced detrimental effect with increasing age.",
    "authors": [
        {
            "affiliation": "Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.",
            "firstname": "He",
            "initials": "H",
            "lastname": "Cai"
        },
        {
            "affiliation": "Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.",
            "firstname": "Xia",
            "initials": "X",
            "lastname": "Xue"
        },
        {
            "affiliation": "Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.",
            "firstname": "Xiaohua",
            "initials": "X",
            "lastname": "Liu"
        },
        {
            "affiliation": "Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.",
            "firstname": "Haiyan",
            "initials": "H",
            "lastname": "Bai"
        },
        {
            "affiliation": "Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.",
            "firstname": "Juanzi",
            "initials": "J",
            "lastname": "Shi"
        }
    ],
    "conclusions": "Maternal obesity was significantly associated with a lower likelihood of having a live birth, but the risk differed according to women's age. A higher BMI might have a less-pronounced detrimental effect with increasing age.",
    "copyrights": "\u00a9 2023 International Federation of Gynecology and Obstetrics.",
    "doi": "10.1002/ijgo.15071",
    "journal": "International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics",
    "keywords": [
        "body mass index",
        "cumulative live birth",
        "female age",
        "in vitro fertilization",
        "obesity",
        "preterm birth"
    ],
    "methods": "We retrospectively analyzed the data of 26\u2009567 women undergoing in vitro fertilization/intracytoplasmic sperm injection from 2016 to 2019. We conducted multivariate regression analysis of the association between CLBRs and maternal BMI and age category.",
    "publication_date": "2023-09-09",
    "pubmed_id": "37688321",
    "results": "A total of 16\u2009626 (62.58%) patients achieved a live birth. Women with obesity had significantly decreased CLBRs compared with women who had normal weight (odds ratio [OR] 0.73 [95% confidence interval (CI), 0.66-0.80]). The significant interaction between age and BMI suggested that the impact of BMI on CLBRs was moderated by women's age (P interaction <0.001). The association between obesity and CLBRs was inverse among women aged <30\u2009years (OR, 0.63 [95% CI, 0.54-0.73]), 30 to 34\u2009years (OR, 0.79 [95% CI, 0.67-0.93]), and 35 to 37\u2009years (OR, 0.71 [95% CI, 0.52-0.98]); however, decreases in CLBRs with obesity were not observed in women aged 38 to 40\u2009years (OR, 1.17 [95% CI, 0.70-1.94]) and\u2009\u2265\u200941\u2009years (OR, 1.25 [95% CI, 0.53-2.96]).",
    "title": "Association of overweight and obesity with cumulative live birth rates according to women's age: A cohort study of 26\u2009567 treatment cycles.",
    "xml": "<Element 'PubmedArticle' at 0x788507117470>"
}