{
    "abstract": "The LD\nThis study aimed to determine the acute toxicity of an oral lethal dose of 50% (LD\nThere were 66 DDG (Deutschland Denken Yoken) mice in 11 groups of six in this investigation. The daylong metabolic cage study contained one control (C) and 10 treatment groups that received different EG doses. EG's daily BW/kg dosage varied from 0.5 mg/kg to 15,000 mg/kg. The treatment group was given a single dose of EG at a dose of T1 = 0.5 mg/kg BW, T2 = 1.57 mg/kg BW, T3 = 4.94 mg/kg BW, T4 = 15.54 mg/kg BW, T5 = 48.84 mg/kg BW, T6 = 153.55 mg/kg BW, T7 = 482.74 mg/kg BW, and T8 = 1517.66 mg/kg BW T9 = 4771.24 mg/kg BW, T10 = 14999.99 \u2248 15. 000 mg/kg BW. One-way Analysis of Variance testing was used to analyze the data.\nThe LD\nAcute EG exposure caused renal failure in male mice. Acute exposure to EG causes renal tubular cell degeneration and inflammation, indicating toxicity and health hazards.",
    "authors": [
        {
            "affiliation": "Division of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.",
            "firstname": "Dewa Ketut",
            "initials": "DK",
            "lastname": "Meles"
        },
        {
            "affiliation": "Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.",
            "firstname": "Imam",
            "initials": "I",
            "lastname": "Mustofa"
        },
        {
            "affiliation": "Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.",
            "firstname": "Wurlina",
            "initials": "W",
            "lastname": "Wurlina"
        },
        {
            "affiliation": "Profession Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.",
            "firstname": "Clarissa Audreylea",
            "initials": "CA",
            "lastname": "Donova"
        },
        {
            "affiliation": "Profession Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.",
            "firstname": "Essi Rayareswari",
            "initials": "ER",
            "lastname": "Hidayanti"
        },
        {
            "affiliation": "Department of Clinical Pathology, Universitas Katolik Widya Mandala Surabaya, Surabaya, Indonesia.",
            "firstname": "Niluh",
            "initials": "N",
            "lastname": "Suwasanti"
        },
        {
            "affiliation": "Division of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.",
            "firstname": "Zulfi Nur Amrina",
            "initials": "ZNA",
            "lastname": "Rosyada"
        },
        {
            "affiliation": "Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia.",
            "firstname": "Aswin Rafif",
            "initials": "AR",
            "lastname": "Khairullah"
        },
        {
            "affiliation": "Department of Agriculture and Industrial Technology, Babcock University, Ilishan-Remo, Nigeria.",
            "firstname": "Adeyinka Oye",
            "initials": "AO",
            "lastname": "Akintunde"
        },
        {
            "affiliation": "Physician in Nayaka Hostpital, Surabaya, Indonesia.",
            "firstname": "Rheza Imawan",
            "initials": "RI",
            "lastname": "Mustofa"
        },
        {
            "affiliation": "Internship Physician in Rumah Sakit Angkatan Udara, Malang, Indonesia.",
            "firstname": "Satriawan Wedniyanto",
            "initials": "SW",
            "lastname": "Putra"
        },
        {
            "affiliation": "Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia.",
            "firstname": "Riza Zainuddin",
            "initials": "RZ",
            "lastname": "Ahmad"
        },
        {
            "affiliation": "Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia.",
            "firstname": "Wasito",
            "initials": "W",
            "lastname": "Wasito"
        },
        {
            "affiliation": "Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, Indonesia.",
            "firstname": "Ricadonna",
            "initials": "R",
            "lastname": "Raissa"
        }
    ],
    "conclusions": "Acute EG exposure caused renal failure in male mice. Acute exposure to EG causes renal tubular cell degeneration and inflammation, indicating toxicity and health hazards.",
    "copyrights": null,
    "doi": "10.5455/OVJ.2024.v14.i12.36",
    "journal": "Open veterinary journal",
    "keywords": [
        "Disease",
        "EG",
        "LD50",
        "Renal",
        "Toxic"
    ],
    "methods": null,
    "publication_date": "2025-02-10",
    "pubmed_id": "39927377\n37761859\n23798302\n33626883\n30181707\n27192089\n28689762\n31410405\n36765419\n34298086\n19931368\n35276844\n26566024\n34970253\n23800279\n28651171\n28303073\n30450373\n21971647\n37252589\n34901567\n22085425\n29602397\n16164631\n29399024\n25870701\n31998852\n25558060\n25560066",
    "results": "The LD",
    "title": "Acute toxicity effects of ethylene glycol on lethal dose 50 (LD",
    "xml": "<Element 'PubmedArticle' at 0x788504a5a520>"
}