{
    "abstract": "It is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. In clinical cases of placental villi positive for HPV DNA reported by other authors, contamination is suspected in the act of crossing the cervical canal. We analyzed placental samples of women who resorted to elective abortion obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina.\nWe studied the chorionic villi of the placenta of 64 women who resorted to voluntary termination of pregnancy, in the first trimester. To avoid contamination of the villi by the cervical canal, we analyzed placental samples obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina. All samples of chorionic villi were manually selected from the aborted material and subjected to research for HPV DNA.\nHPV DNA was detected in 10 out of 60 women (16.6%). The HPV DNA identified in the placenta belonged to genotypes 6, 16, 35, 53, and 90.\nThe study shows that papillomavirus DNA can infect the placenta and that placenta HPV infection can occur as early as the first trimester of pregnancy.",
    "authors": [
        {
            "affiliation": "Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy. mt.bruno@unict.it.",
            "firstname": "Maria Teresa",
            "initials": "MT",
            "lastname": "Bruno"
        },
        {
            "affiliation": "Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.",
            "firstname": "Salvatore",
            "initials": "S",
            "lastname": "Caruso"
        },
        {
            "affiliation": "Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.",
            "firstname": "Francesca",
            "initials": "F",
            "lastname": "Bica"
        },
        {
            "affiliation": "Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.",
            "firstname": "Giulia",
            "initials": "G",
            "lastname": "Arcidiacono"
        },
        {
            "affiliation": "Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.",
            "firstname": "Sara",
            "initials": "S",
            "lastname": "Boemi"
        }
    ],
    "conclusions": "The study shows that papillomavirus DNA can infect the placenta and that placenta HPV infection can occur as early as the first trimester of pregnancy.",
    "copyrights": null,
    "doi": "10.1186/s12884-021-03937-9\n10.11138/giog/2016.38.5.376\n10.1186/s12885-020-06946-7\n10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F\n10.1016/S0002-9378(97)70399-5\n10.1016/j.placenta.2007.08.005\n10.1006/viro.2001.1135\n10.1080/01443615.2018.1454408\n10.1023/a:1007975005433\n10.1016/s0029-7844(00)00953-4\n10.1093/infdis/jiq056\n10.1093/humrep/dem404\n10.4236/jct.2015.615140\n10.1016/j.jri.2011.01.005\n10.1016/j.fertnstert.2008.10.050\n10.1016/j.rbmo.2014.12.016\n10.1128/JCM.43.11.5428-5434.2005\n10.1093/ajcp/95.4.540\n10.1046/j.1523-1747.1998.00312.x\n10.1371/journal.pone.0012816\n10.1186/s12985-018-0957-z\n10.1086/517266\n10.1002/jmv.1890470305\n10.1016/j.jpeds.2011.10.027\n10.1186/1743-422X-9-80\n10.1023/a:1007975005433\n10.1186/1471-2393-13-173\n10.1111/jog.12155\n10.1186/s12985-019-1252-3\n10.1080/0092623X.2019.1586019",
    "journal": "BMC pregnancy and childbirth",
    "keywords": [
        "Colposcopy",
        "HPV DNA",
        "HPV infection",
        "Placenta",
        "Pregnancy, chorionic villi"
    ],
    "methods": null,
    "publication_date": "2021-07-08",
    "pubmed_id": "34229658\n32429930\n10451482\n9166165\n23446269\n17905430\n11887784\n12496366\n29884100\n27110088\n9208451\n10960622\n21208925\n18184644\n26865986\n21353708\n19100537\n25684094\n16272465\n1849701\n9699739\n20862247\n29587778\n9207382\n8551271\n22137368\n22497663\n9208451\n24011340\n24096182\n23815316\n31775792\n30836859",
    "results": "HPV DNA was detected in 10 out of 60 women (16.6%). The HPV DNA identified in the placenta belonged to genotypes 6, 16, 35, 53, and 90.",
    "title": "Evidence for HPV DNA in the placenta of women who resorted to elective abortion.",
    "xml": "<Element 'PubmedArticle' at 0x788504f54220>"
}