{
    "abstract": "Low molecular weight heparin (LMWH) is a common agent given in pregnancy; however, cutaneous drug reactions with its use in pregnancy are rarely reported. The case describes a 30-year-old woman with stable Crohn's disease on ustekinumab presenting with a rash at prophylactic LMWH injection sites 30 weeks into her third pregnancy. Skin biopsy reported appearance consistent with an urticarial drug hypersensitivity reaction. A combination of steroid treatment, topical emollient and cessation of LMWH resulted in resolution of symptoms over 2 weeks. Postnatal venous thromboembolism prophylaxis with fondaparinux was uncomplicated. Overall, this case highlights the importance of reporting drug reactions in pregnancy. It additionally exposes a gap in research surrounding immunomodulators and heparins in the development of cutaneous reactions in pregnancy.",
    "authors": [
        {
            "affiliation": "Women's and Children's Department, North Bristol NHS Trust, Bristol, UK.",
            "firstname": "Amanda",
            "initials": "A",
            "lastname": "Hill"
        },
        {
            "affiliation": "Women's and Children's Department, North Bristol NHS Trust, Bristol, UK.",
            "firstname": "Charlotte",
            "initials": "C",
            "lastname": "Williams"
        },
        {
            "affiliation": "Department of Dermatology, North Bristol NHS Trust, Bristol, UK.",
            "firstname": "Katherine",
            "initials": "K",
            "lastname": "Finucane"
        },
        {
            "affiliation": "Department of Histopathology, North Bristol NHS Trust, Bristol, UK.",
            "firstname": "Naomi",
            "initials": "N",
            "lastname": "Carson"
        },
        {
            "affiliation": "Women's and Children's Department, North Bristol NHS Trust, Bristol, UK.",
            "firstname": "Francesca",
            "initials": "F",
            "lastname": "Neuberger"
        },
        {
            "affiliation": "Department of Dermatology, North Bristol NHS Trust, Bristol, UK.",
            "firstname": "Fangyi",
            "initials": "F",
            "lastname": "Xie"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 The Author(s) 2025.",
    "doi": "10.1177/1753495X251317303",
    "journal": "Obstetric medicine",
    "keywords": [
        "Pregnancy complications",
        "infectious"
    ],
    "methods": null,
    "publication_date": "2025-02-17",
    "pubmed_id": "39958412\n19786468\n35788063\n10392668\n37334488\n31827408\n31578718\n38280679\n35463677\n34192360\n35090948\n317125",
    "results": null,
    "title": "Urticarial reaction to low molecular weight heparin injections.",
    "xml": "<Element 'PubmedArticle' at 0x788504515210>"
}