{
    "abstract": "Probiotics are beneficial live microorganisms that can modify the gut microbiota. It is assumed that they help improve enteral feeding intolerance (EFI) and nosocomial infections in critically ill patients. The present clinical trial aimed to investigate the efficacy of synbiotics in improving EFI and oropharyngeal aspiration in patients admitted to the intensive care unit (ICU).\nThis randomized clinical trial was conducted on 105 critically ill patients admitted to the ICU of a tertiary referral hospital affiliated with a medical university. The patients were randomly assigned to either a synbiotic or control group and underwent 7 days of investigation. The primary end point was reduced gastric residual volume, which is suggestive of an improvement in EFI. The secondary end point included requirement for prokinetics, frequency of aspiration, duration of mechanical ventilation, length of ICU stay, and level of consciousness.\nThe present clinical trial showed that synbiotic intervention has resulted in a significantly diminished requirement for prokinetics (P\u2009=\u20090.019), fewer oropharyngeal aspirations (P\u2009=\u20090.01), improved volume of bolus administration, and decreased gastric residual volume during the 7-day follow-up period. The patients who received synbiotic had an improved level of consciousness (P\u2009=\u20090.01).\nThis clinical trial showed that the prescription of synbiotic from the initial days of enteral feeding has resulted in a significantly diminished requirement for prokinetics, less oropharyngeal aspiration, decreased gastric residual volume, improved volume of bolus administration, and hence, better tolerance of enteral feeding.",
    "authors": [
        {
            "affiliation": "Department of Anesthesiology and Critical Care, Shahid Rahnemoun Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.",
            "firstname": "Mohammad Hossein",
            "initials": "MH",
            "lastname": "Dehghani"
        },
        {
            "affiliation": "Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.",
            "firstname": "Fatemeh",
            "initials": "F",
            "lastname": "Saghafi"
        },
        {
            "affiliation": "Department of Clinical Pharmacy, Faculty of Pharmacy, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.",
            "firstname": "Zeinab",
            "initials": "Z",
            "lastname": "Bordbari"
        },
        {
            "affiliation": "Department of Clinical Pharmacy, Faculty of Pharmacy, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.",
            "firstname": "Javad",
            "initials": "J",
            "lastname": "Zare-Kamali"
        },
        {
            "affiliation": "Department of Surgery, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.",
            "firstname": "Jamal",
            "initials": "J",
            "lastname": "Jafari-Nedooshan"
        },
        {
            "affiliation": "Clinical Research Center, Department of Internal Medicine, School of Medicine, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.",
            "firstname": "Adeleh",
            "initials": "A",
            "lastname": "Sahebnasagh"
        }
    ],
    "conclusions": "This clinical trial showed that the prescription of synbiotic from the initial days of enteral feeding has resulted in a significantly diminished requirement for prokinetics, less oropharyngeal aspiration, decreased gastric residual volume, improved volume of bolus administration, and hence, better tolerance of enteral feeding.",
    "copyrights": "\u00a9 2022 American Society for Parenteral and Enteral Nutrition.",
    "doi": "10.1002/ncp.10895",
    "journal": "Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition",
    "keywords": [
        "aspiration",
        "critical illness",
        "enteral nutrition",
        "gastric residual",
        "microbiota",
        "prebiotic",
        "probiotic",
        "synbiotic"
    ],
    "methods": null,
    "publication_date": "2022-07-10",
    "pubmed_id": "35809224",
    "results": "The present clinical trial showed that synbiotic intervention has resulted in a significantly diminished requirement for prokinetics (P\u2009=\u20090.019), fewer oropharyngeal aspirations (P\u2009=\u20090.01), improved volume of bolus administration, and decreased gastric residual volume during the 7-day follow-up period. The patients who received synbiotic had an improved level of consciousness (P\u2009=\u20090.01).",
    "title": "Investigating the effect of oral synbiotic on enteral feeding tolerance in critically ill patients: A double-blinded controlled clinical trial of gut microbiota.",
    "xml": "<Element 'PubmedArticle' at 0x788503bad6c0>"
}