{
    "abstract": "Endoplasmic reticulum (ER) stress is involved in hypertension related cardiac remodeling. We aimed to evaluate the effects of Huoxue Qianyang (HXQY) decoction on cardiac remodeling in obese spontaneously hypertensive rats (SHRs), and explore its impacts on the activating transcription factor 6 (ATF6)-C/EBP homologous protein (CHOP) ER stress signaling pathway.\nTwenty-seven obese SHRs were randomly divided into Obese SHR, Obese SHR\u202f+\u202fHXQY and Obese SHR\u202f+\u202fValsartan groups, and treated with the indicated drugs for 8 weeks. Nine age-matched male SHRs were used as controls. Systolic blood pressure (SBP), body weight (BW), and the left ventricular mass index (LVMI) were measured weekly or at end point. Then, angiotensin II (Ang II), fasting glucose (FPG) and fasting insulin (FIN), total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and triglyceride (TG) levels were evaluated with commercial kits. Apoptotic cardiomyocytes were detected by the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method. The expression levels of GRP78, ATF6, PERK/pPERK and CHOP were assessed by quantitative PCR and Western blot.\nTreatment with HXQY decoction resulted in significantly reduced SBP, BW, LVMI, Ang II, TC and LDL-C levels, as well as the homeostasis model assessment of insulin resistance (HOMA-IR) score in obese SHRs. Apoptosis in heart tissues of obese SHRs was significantly attenuated after HXQY decoction administration, paralleling reduced expression of GRP78, ATF6, PERK/pPERK and CHOP at both mRNA and protein levels.\nCardiac remodeling in obese SHRs is ameliorated by intervention with HXQY decoction in association with inhibited ATF6-CHOP ER stress signaling pathway.",
    "authors": [
        {
            "affiliation": "Yueyang Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.",
            "firstname": "Xunjie",
            "initials": "X",
            "lastname": "Zhou"
        },
        {
            "affiliation": "Yueyang Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.",
            "firstname": "Bo",
            "initials": "B",
            "lastname": "Lu"
        },
        {
            "affiliation": "Yueyang Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Electronic address: fudeyu1965@outlook.com.",
            "firstname": "Deyu",
            "initials": "D",
            "lastname": "Fu"
        },
        {
            "affiliation": "Yueyang Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.",
            "firstname": "Mingtai",
            "initials": "M",
            "lastname": "Gui"
        },
        {
            "affiliation": "Yueyang Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.",
            "firstname": "Lei",
            "initials": "L",
            "lastname": "Yao"
        },
        {
            "affiliation": "Yueyang Hospital of Intergrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.",
            "firstname": "Jianhua",
            "initials": "J",
            "lastname": "Li"
        }
    ],
    "conclusions": "Cardiac remodeling in obese SHRs is ameliorated by intervention with HXQY decoction in association with inhibited ATF6-CHOP ER stress signaling pathway.",
    "copyrights": "Copyright \u00a9 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.",
    "doi": "10.1016/j.biopha.2019.109518",
    "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
    "keywords": [
        "Cardiac remodeling",
        "Endoplasmic reticulum stress",
        "HXQY decoction",
        "Hypertension",
        "Obesity",
        "Spontaneously hypertensive rat"
    ],
    "methods": null,
    "publication_date": "2019-11-07",
    "pubmed_id": "31689600",
    "results": "Treatment with HXQY decoction resulted in significantly reduced SBP, BW, LVMI, Ang II, TC and LDL-C levels, as well as the homeostasis model assessment of insulin resistance (HOMA-IR) score in obese SHRs. Apoptosis in heart tissues of obese SHRs was significantly attenuated after HXQY decoction administration, paralleling reduced expression of GRP78, ATF6, PERK/pPERK and CHOP at both mRNA and protein levels.",
    "title": "Huoxue Qianyang decoction ameliorates cardiac remodeling in obese spontaneously hypertensive rats in association with ATF6-CHOP endoplasmic reticulum stress signaling pathway regulation.",
    "xml": "<Element 'PubmedArticle' at 0x7885033a5ad0>"
}