{
    "abstract": "Multilayered osteochondral scaffolds are becoming increasingly utilized for the repair of knee joint surface lesions (KJSLs). However, the literature on predictive factors is rather limited.\nTo (1) evaluate the clinical outcomes and safety of a combined single-step approach using a biomimetic collagen-hydroxyapatite scaffold (CHAS) and filtered bone marrow aspirate (fBMA) for the treatment of KJSLs and (2) identify significant predictors of the treatment outcomes.\nCase series; Level of evidence, 4.\nAll patients who underwent surgery because of a KJSL (size \u22651.5 cm\nAt a mean follow-up of 54.2 \u00b1 19.4 months, 78 (87%) patients completed the questionnaires with significant improvements toward the baseline (\nA CHAS augmented with fBMA proved to be an adequate and safe approach for the treatment of KJSLs up to midterm follow-up. Based on the subanalysis of predictive factors, the surgical intervention should be performed in a timely and precise manner to prevent lesion enlargement, deterioration of the general knee cartilage status, and recurrent surgical procedures, especially in older and female patients. When a CHAS is used, the quantity of MSCs seems to play a role in augmentation.\nNCT06078072 (ClinicalTrials.gov identifier).",
    "authors": [
        {
            "affiliation": "Department of Orthopaedic Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.\nFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.",
            "firstname": "Matic",
            "initials": "M",
            "lastname": "Kolar"
        },
        {
            "affiliation": "Educell, Trzin, Slovenia.",
            "firstname": "Matija",
            "initials": "M",
            "lastname": "Veber"
        },
        {
            "affiliation": "Educell, Trzin, Slovenia.",
            "firstname": "Lenart",
            "initials": "L",
            "lastname": "Girandon"
        },
        {
            "affiliation": "Department of Orthopaedic Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.\nFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.",
            "firstname": "Matej",
            "initials": "M",
            "lastname": "Drobni\u010d"
        }
    ],
    "conclusions": "A CHAS augmented with fBMA proved to be an adequate and safe approach for the treatment of KJSLs up to midterm follow-up. Based on the subanalysis of predictive factors, the surgical intervention should be performed in a timely and precise manner to prevent lesion enlargement, deterioration of the general knee cartilage status, and recurrent surgical procedures, especially in older and female patients. When a CHAS is used, the quantity of MSCs seems to play a role in augmentation.",
    "copyrights": null,
    "doi": "10.1177/03635465241247788",
    "journal": "The American journal of sports medicine",
    "keywords": [
        "Chondropenia Severity Score",
        "bone marrow aspirate",
        "cartilage",
        "collagen",
        "hydroxyapatite",
        "knee",
        "mesenchymal stem cell",
        "osteochondral",
        "scaffold"
    ],
    "methods": null,
    "publication_date": "2024-05-20",
    "pubmed_id": "38767159",
    "results": "At a mean follow-up of 54.2 \u00b1 19.4 months, 78 (87%) patients completed the questionnaires with significant improvements toward the baseline (",
    "title": "A Biomimetic Osteochondral Scaffold Augmented With Filtered Bone Marrow Aspirate for the Treatment of Joint Surface Lesions in the Knee.",
    "xml": "<Element 'PubmedArticle' at 0x788504a77560>"
}