{
    "abstract": "The objective of this research was to explore the effect of dioscin on myocardium in streptozotocin (STZ)-induced diabetic rats and the underlying mechanisms.\nDiabetic rat model was established by a single intravenous injection of streptozocin (STZ). The rats were divided into 5 groups: control group, control+dioscin group, model group (diabetes), DDL group (diabetic rats treated with 100 \u03bcg/kg/day dioscin) and DDH group (diabetic rats treated with 200 \u03bcg/kg/day dioscin). Each group was continuously intervened for 6 weeks. Hemodynamic parameters were detected and pathological alterations of myocardium were observed by hematoxylin-eosin (HE) staining. Inflammatory response and related proteins in the NO-sGC-cGMP-PKG pathway were detected by western blot.\nDioscin treatment can increase ejection fraction (EF) and decrease left ventricular end-diastolic pressure (LVEDP) as well as time constant of left ventricular pressure decay (Tau) parameters in diabetic rats, suggesting the improvement of left ventricular function. By histopathology observation, we found that dioscin treatment can also improve myocardial histological lesions caused by diabetes. In addition, the levels of inflammatory cytokines TGF-\u03b21, TNF-\u03b1 and IL-1\u03b2 of the model group were remarkably higher than those in the control group (\nDioscin may prevent the myocardial injury in diabetic rats by up-regulating NO-sGC-cGMP-PKG pathway.",
    "authors": [
        {
            "affiliation": "Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.",
            "firstname": "Qian",
            "initials": "Q",
            "lastname": "Wei"
        },
        {
            "affiliation": "Department of Lung Disease, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.",
            "firstname": "Tonggang",
            "initials": "T",
            "lastname": "Zhu"
        },
        {
            "affiliation": "Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.",
            "firstname": "Xue",
            "initials": "X",
            "lastname": "Xiao"
        },
        {
            "affiliation": "School of Humanities Management, Changchun University of Chinese Medicine, Changchun, Jilin, China.",
            "firstname": "Li",
            "initials": "L",
            "lastname": "Sun"
        },
        {
            "affiliation": "Department of Heart Disease, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.",
            "firstname": "Zhaozhi",
            "initials": "Z",
            "lastname": "Zhang"
        },
        {
            "affiliation": "Department of Emergency, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China huangtaoyeah@sina.com.",
            "firstname": "Tao",
            "initials": "T",
            "lastname": "Huang"
        }
    ],
    "conclusions": "Dioscin may prevent the myocardial injury in diabetic rats by up-regulating NO-sGC-cGMP-PKG pathway.",
    "copyrights": "\u00a9 2019 by the Association of Clinical Scientists, Inc.",
    "doi": null,
    "journal": "Annals of clinical and laboratory science",
    "keywords": [
        "Dioscin",
        "NO-sGC-cGMP-PKG pathway",
        "diabetic cardiomyopathy",
        "myocardial inflamation"
    ],
    "methods": null,
    "publication_date": "2019-03-01",
    "pubmed_id": "30814084",
    "results": "Dioscin treatment can increase ejection fraction (EF) and decrease left ventricular end-diastolic pressure (LVEDP) as well as time constant of left ventricular pressure decay (Tau) parameters in diabetic rats, suggesting the improvement of left ventricular function. By histopathology observation, we found that dioscin treatment can also improve myocardial histological lesions caused by diabetes. In addition, the levels of inflammatory cytokines TGF-\u03b21, TNF-\u03b1 and IL-1\u03b2 of the model group were remarkably higher than those in the control group (",
    "title": "Dioscin Attenuates Myocardial Damages in Diabetic Rats maybe by Regulating NO-sGC-cGMP-PKG Pathway.",
    "xml": "<Element 'PubmedArticle' at 0x788503bda570>"
}