{
    "abstract": "Changes in ventilatory variables (VE, VE, f, Tl/Ttot, VT/Tl, PE'CO2) were studied in 12 unpremedicated children, weighing between 10 and 20 kg, during halothane anaesthesia. At an inspired concentration of 0.5% halothane, respiratory rate increased, VT decreased, and VE did not change markedly. When the inspired halothane concentration increased further, there was a significant decrease in VE, mainly as a result of a marked decrease in VT. PE'CO2 increased significantly and inspiratory duty cycle decreased at high inspired halothane concentrations. On return to baseline (0.5% halothane), there was a significant decrease in inspiratory timing and a significant increase in PE'CO2. The relations between these changes and the effect of halothane on inspiratory muscles are discussed.",
    "authors": [
        {
            "affiliation": null,
            "firstname": "I",
            "initials": "I",
            "lastname": "Murat"
        },
        {
            "affiliation": null,
            "firstname": "M M",
            "initials": "MM",
            "lastname": "Delleur"
        },
        {
            "affiliation": null,
            "firstname": "K",
            "initials": "K",
            "lastname": "MacGee"
        },
        {
            "affiliation": null,
            "firstname": "C",
            "initials": "C",
            "lastname": "Saint-Maurice"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.1093/bja/57.6.569",
    "journal": "British journal of anaesthesia",
    "keywords": [],
    "methods": null,
    "publication_date": "1985-06-01",
    "pubmed_id": "3924083",
    "results": null,
    "title": "Changes in ventilatory patterns during halothane anaesthesia in children.",
    "xml": "<Element 'PubmedArticle' at 0x788503b07ce0>"
}