{
    "abstract": "In dairy cow, the peripartum metabolic stage is critical as may affect post-partum metabolic and reproductive recovery, colostrum quality, and overall reproductive fitness. This study aimed to evaluate the effects of varying doses of \u03b1-ketoglutarate (AKG) on lactation performance, reproductive performance, immune function, and antioxidant capacity in periparturient dairy cows. A total of 180 periparturient dairy cows were randomly assigned to four groups, with each cow receiving 1 g, 5 g, or 10 g of AKG in their prepartum diets. Results indicated that feeding 5 g and 10 g of AKG significantly increased the colostrum fat and protein content, reduced somatic cell counts, and improved daily milk yield. Regarding reproduction, AKG supplementation regulated reproductive hormones, increased postpartum estrogen levels, improved conception rates, and shortened the interval between breeding periods. For immune and antioxidant functions, AKG significantly increased serum IL-10 levels while reducing TNF-\u03b1 and interleukins 1\u03b2 and 6. It also significantly elevated glutathione peroxidase (GSH-PX) levels, reducing oxidative stress and demonstrating anti-inflammatory and immunomodulatory effects. Additionally, cows receiving medium-to-high doses of AKG had a significantly lower incidence of postpartum diseases such as mastitis. In conclusion, appropriate AKG supplementation can improve lactation performance, reproductive performance, immune function, and overall health in periparturient dairy cows, providing a theoretical basis for its use in dairy cow nutrition management.",
    "authors": [
        {
            "affiliation": "Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
            "firstname": "Peng",
            "initials": "P",
            "lastname": "Wang"
        },
        {
            "affiliation": "Beijing Changping District Animal Disease Prevention and Control Centre, Beijing 102200, China.",
            "firstname": "Xin",
            "initials": "X",
            "lastname": "Hu"
        },
        {
            "affiliation": "Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
            "firstname": "Xiang'ao",
            "initials": "X",
            "lastname": "Shan"
        },
        {
            "affiliation": "Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
            "firstname": "Jiarui",
            "initials": "J",
            "lastname": "Gao"
        },
        {
            "affiliation": "Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
            "firstname": "Fei",
            "initials": "F",
            "lastname": "Guo"
        },
        {
            "affiliation": "Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
            "firstname": "Bingyuan",
            "initials": "B",
            "lastname": "Wang"
        },
        {
            "affiliation": "Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
            "firstname": "Guoshi",
            "initials": "G",
            "lastname": "Liu"
        }
    ],
    "conclusions": null,
    "copyrights": null,
    "doi": "10.3390/ani15081110",
    "journal": "Animals : an open access journal from MDPI",
    "keywords": [
        "immunity and antioxidation",
        "lactation performance",
        "periparturient dairy cows",
        "reproductive performance",
        "\u03b1-ketoglutarate"
    ],
    "methods": null,
    "publication_date": "2025-04-26",
    "pubmed_id": "40281944",
    "results": null,
    "title": "Effects of \u03b1-Ketoglutarate Peripartum Supplementation on Reproductive, Lactational, Productive and Immunological Outcomes in Dairy Cows.",
    "xml": "<Element 'PubmedArticle' at 0x788506f52ac0>"
}