{
    "abstract": "Anaemia is common in end-stage heart failure patients supported with continuous flow left ventricular assist device (CF-LVAD) and is associated with adverse outcomes such as heart failure readmission. This study evaluates the haemodynamic effects of anaemia on cardiac function and cerebral blood flow in heart failure patients supported with CF-LVAD using computational simulations. A dynamic model simulating cardiac function, systemic, pulmonary and cerebral circulations, cerebral flow autoregulatory mechanisms and gas contents in blood was used to evaluate the effects of anaemia and iron deficiency in heart failure and during CF-LVAD support. CF-LVAD therapy was simulated by a model describing HeartMate 3. Anaemia and iron deficiency were simulated by reducing the haemoglobin level from 15 to 9\u2009g/dL and modifying scaling coefficients in the models simulating heart chamber volumes. Reduced haemoglobin levels decreased the arterial O",
    "authors": [
        {
            "affiliation": "School of Engineering, Ulster University, Belfast, UK.",
            "firstname": "Selim",
            "initials": "S",
            "lastname": "Bozkurt"
        }
    ],
    "conclusions": null,
    "copyrights": "\u00a9 2023 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.",
    "doi": "10.1002/cnm.3781",
    "journal": "International journal for numerical methods in biomedical engineering",
    "keywords": [
        "anaemia",
        "heart failure",
        "iron deficiency",
        "left ventricular assist device"
    ],
    "methods": null,
    "publication_date": "2023-10-10",
    "pubmed_id": "37814938",
    "results": null,
    "title": "Computational evaluation of heart failure and continuous flow left ventricular assist device support in anaemia.",
    "xml": "<Element 'PubmedArticle' at 0x788504fc3ce0>"
}