{
    "abstract": "The Scottish Inflammatory Prognostic Score (SIPS), an innovative scoring system, has emerged as a promising biomarker for predicting patient outcomes following cancer therapy. This study aimed to evaluate the value of SIPS as a prognostic indicator following hepatectomy in patients with hepatocellular carcinoma (HCC).\nThis retrospective study included 693 HCC patients who underwent hepatectomy. Survival outcomes were compared between propensity score-matched groups. Independent prognostic factors were identified through Cox regression analysis. Additionally, both traditional Cox proportional hazards models and machine learning models based on the SIPS were developed and validated.\nA total of 693 HCC patients who underwent hepatectomy were included, with 102 in the high SIPS group and 591 in the low SIPS group. Following propensity score matching (1:3 ratio), both groups achieved balance, with 82 patients in the high SIPS group and 240 patients in the low SIPS group. The low SIPS group demonstrated significantly superior recurrence-free survival (RFS) (25 months vs. 21 months; P\u2009<\u20090.001) and overall survival (OS) (69 months vs. 58 months; P\u2009<\u20090.001) compared to the high SIPS group. Multivariable analysis identified SIPS as an independent adverse factor affecting both RFS and OS. The calibration curve for overall patient survival diagnosis displayed excellent predictive accuracy. Traditional COX prognostic models and machine learning models incorporating SIPS demonstrated excellent performance both the training and validation set.\nThis study confirms the prognostic significance of SIPS in post-hepatectomy HCC patients, providing a practical tool for risk stratification and clinical decision-making. Further research and validation are needed to consolidate its role in prognostic assessment.",
    "authors": [
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, China.\nKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Nanning, 530021, China.",
            "firstname": "Shuang",
            "initials": "S",
            "lastname": "Shen"
        },
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, China.\nDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.",
            "firstname": "Xin",
            "initials": "X",
            "lastname": "Qiu"
        },
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, China.",
            "firstname": "Chenglei",
            "initials": "C",
            "lastname": "Yang"
        },
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, China.",
            "firstname": "Jindu",
            "initials": "J",
            "lastname": "Li"
        },
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, China.",
            "firstname": "Yi",
            "initials": "Y",
            "lastname": "Peng"
        },
        {
            "affiliation": "Oncology School, Guangxi Medical University, Nanning, 530021, China.",
            "firstname": "Zhaochan",
            "initials": "Z",
            "lastname": "Wen"
        },
        {
            "affiliation": "College of Basic Medicine, Guangxi Medical University, Nanning, 530199, China.",
            "firstname": "Huili",
            "initials": "H",
            "lastname": "Luo"
        },
        {
            "affiliation": "Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, China. xiangbangde@gxmu.edu.cn.\nKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Nanning, 530021, China. xiangbangde@gxmu.edu.cn.",
            "firstname": "Bangde",
            "initials": "B",
            "lastname": "Xiang"
        }
    ],
    "conclusions": "This study confirms the prognostic significance of SIPS in post-hepatectomy HCC patients, providing a practical tool for risk stratification and clinical decision-making. Further research and validation are needed to consolidate its role in prognostic assessment.",
    "copyrights": "\u00a9 2024. The Author(s).",
    "doi": "10.1186/s12885-024-13174-w",
    "journal": "BMC cancer",
    "keywords": [
        "Hepatectomy",
        "Hepatocellular carcinoma",
        "Machine learning",
        "Prognostic biomarkers",
        "Propensity score matching (PSM)",
        "Scottish inflammatory prognostic score (SIPS)"
    ],
    "methods": null,
    "publication_date": "2024-11-13",
    "pubmed_id": "39533231\n33538338\n30367835\n36082510\n36084663\n12490959\n31417011\n34127809\n33178607\n28479010\n30051372\n38295631\n35398717\n29482517\n14695641\n33230128\n34459122\n36835413\n21376230\n34230649\n31160735\n21176210\n15660573\n25148079\n18582981\n24275343\n34765293\n32895384\n35022268\n36901717",
    "results": "A total of 693 HCC patients who underwent hepatectomy were included, with 102 in the high SIPS group and 591 in the low SIPS group. Following propensity score matching (1:3 ratio), both groups achieved balance, with 82 patients in the high SIPS group and 240 patients in the low SIPS group. The low SIPS group demonstrated significantly superior recurrence-free survival (RFS) (25 months vs. 21 months; P\u2009<\u20090.001) and overall survival (OS) (69 months vs. 58 months; P\u2009<\u20090.001) compared to the high SIPS group. Multivariable analysis identified SIPS as an independent adverse factor affecting both RFS and OS. The calibration curve for overall patient survival diagnosis displayed excellent predictive accuracy. Traditional COX prognostic models and machine learning models incorporating SIPS demonstrated excellent performance both the training and validation set.",
    "title": "Prognostic importance of the Scottish inflammatory prognostic score in patients with hepatocellular carcinoma after hepatectomy: a retrospective cohort study.",
    "xml": "<Element 'PubmedArticle' at 0x788502181d00>"
}